David Carley

Summary

Affiliation: University of Illinois at Chicago
Country: USA

Publications

  1. ncbi request reprint Functional role for cannabinoids in respiratory stability during sleep
    David W Carley
    Department of Medicine, University of Illinois at Chicago, 60612, USA
    Sleep 25:391-8. 2002
  2. pmc Proof of concept trial of dronabinol in obstructive sleep apnea
    Bharati Prasad
    Department of Medicine, University of Illinois at Chicago Chicago, IL, USA
    Front Psychiatry 4:1. 2013
  3. ncbi request reprint Drug repurposing: identify, develop and commercialize new uses for existing or abandoned drugs. Part I
    David W Carley
    University of Illinois, Department of Medicine M C 787, 840 S Wood Street, Room 824, Chicago, IL 60612, USA
    IDrugs 8:306-9. 2005
  4. ncbi request reprint Drug repurposing: identify, develop and commercialize new uses for existing or abandoned drugs. Part II
    David W Carley
    University of Illinois, Department of Medicine M C 787, 840 S Wood Street, Room 824, Chicago, IL 60612, USA
    IDrugs 8:310-3. 2005
  5. ncbi request reprint Efficacy of mirtazapine in obstructive sleep apnea syndrome
    David W Carley
    Center for Narcolepsy, Sleep and Health Research, Department of Medical Surgical Nursing, University of Illinois, M C 719, Room 910, 40 South Wood Street, Chicago, IL 60612, USA
    Sleep 30:35-41. 2007
  6. ncbi request reprint C-fiber activation exacerbates sleep-disordered breathing in rats
    D W Carley
    Department of Medicine, University of Illinois at Chicago, Chicago, Illinois 60612, USA
    Sleep Breath 8:147-54. 2004
  7. ncbi request reprint R-zacopride, a 5-HT3 antagonist/5-HT4 agonist, reduces sleep apneas in rats
    D W Carley
    Department of Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA
    Pharmacol Biochem Behav 69:283-9. 2001
  8. ncbi request reprint Sleep-disordered respiration in phenotypically normotensive, genetically hypertensive rats
    D W Carley
    Departments of Medicine, Pharmacology, and Bioengineering, University of Illinois at Chicago, Chicago, Illinois, USA
    Am J Respir Crit Care Med 162:1474-9. 2000
  9. ncbi request reprint Role of peripheral serotonin in the regulation of central sleep apneas in rats
    D W Carley
    Department of Medicine, University of Illinois College of Medicine at Chicago, 60612, USA
    Chest 115:1397-401. 1999
  10. pmc Pharmacology of vagal afferent influences on disordered breathing during sleep
    David W Carley
    Center for Narcolepsy, Sleep and Health Research, University of Illinois, Chicago, IL 60612, USA
    Respir Physiol Neurobiol 164:197-203. 2008

Research Grants

  1. NEUROBIOLOGY OF SLEEP APNEA IN AGING
    David W Carley; Fiscal Year: 2010
  2. NEUROBIOLOGY OF SLEEP APNEA IN AGING
    David Carley; Fiscal Year: 2007
  3. NEUROBIOLOGY OF SLEEP APNEA IN AGING
    David Carley; Fiscal Year: 2002
  4. NEUROBIOLOGY OF SLEEP APNEA IN AGING
    David Carley; Fiscal Year: 2006
  5. NEUROBIOLOGY OF SLEEP APNEA IN AGING
    David Carley; Fiscal Year: 2009
  6. NEUROBIOLOGY OF SLEEP APNEA IN AGING
    David Carley; Fiscal Year: 2000
  7. NEUROBIOLOGY OF SLEEP APNEA IN AGING
    David Carley; Fiscal Year: 2003
  8. NEUROBIOLOGY OF SLEEP APNEA IN AGING
    David Carley; Fiscal Year: 2001
  9. NEUROBIOLOGY OF SLEEP APNEA IN AGING
    David Carley; Fiscal Year: 2009

Collaborators

Detail Information

Publications26

  1. ncbi request reprint Functional role for cannabinoids in respiratory stability during sleep
    David W Carley
    Department of Medicine, University of Illinois at Chicago, 60612, USA
    Sleep 25:391-8. 2002
    ....
  2. pmc Proof of concept trial of dronabinol in obstructive sleep apnea
    Bharati Prasad
    Department of Medicine, University of Illinois at Chicago Chicago, IL, USA
    Front Psychiatry 4:1. 2013
    ..5-10 mg daily and significantly reduces AHI in the short-term. These findings should be confirmed in a larger study in order to identify sub-populations with OSA that may benefit from cannabimimetic pharmacologic therapy...
  3. ncbi request reprint Drug repurposing: identify, develop and commercialize new uses for existing or abandoned drugs. Part I
    David W Carley
    University of Illinois, Department of Medicine M C 787, 840 S Wood Street, Room 824, Chicago, IL 60612, USA
    IDrugs 8:306-9. 2005
  4. ncbi request reprint Drug repurposing: identify, develop and commercialize new uses for existing or abandoned drugs. Part II
    David W Carley
    University of Illinois, Department of Medicine M C 787, 840 S Wood Street, Room 824, Chicago, IL 60612, USA
    IDrugs 8:310-3. 2005
  5. ncbi request reprint Efficacy of mirtazapine in obstructive sleep apnea syndrome
    David W Carley
    Center for Narcolepsy, Sleep and Health Research, Department of Medical Surgical Nursing, University of Illinois, M C 719, Room 910, 40 South Wood Street, Chicago, IL 60612, USA
    Sleep 30:35-41. 2007
    ..We sought to determine whether mirtazapine, a mixed 5-HT2/5-HT3 antagonist that also promotes serotonin release in the brain would effectively reduce AHI during both NREM and REM sleep in patients with OSA...
  6. ncbi request reprint C-fiber activation exacerbates sleep-disordered breathing in rats
    D W Carley
    Department of Medicine, University of Illinois at Chicago, Chicago, Illinois 60612, USA
    Sleep Breath 8:147-54. 2004
    ..We conclude that selective pharmacological activation of C-fibers produces a diathesis of sleep-disordered breathing specific to NREM sleep in rats...
  7. ncbi request reprint R-zacopride, a 5-HT3 antagonist/5-HT4 agonist, reduces sleep apneas in rats
    D W Carley
    Department of Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA
    Pharmacol Biochem Behav 69:283-9. 2001
    ..The efficacy of this compound to suppress central apneas most probably arises from its antagonist actions at 5-HT3 receptors or from its mixed agonist/antagonist profile at 5-HT4/5-HT3 receptors...
  8. ncbi request reprint Sleep-disordered respiration in phenotypically normotensive, genetically hypertensive rats
    D W Carley
    Departments of Medicine, Pharmacology, and Bioengineering, University of Illinois at Chicago, Chicago, Illinois, USA
    Am J Respir Crit Care Med 162:1474-9. 2000
    ..The model system described here may provide a powerful tool for investigation of the determinants of sleep-related breathing disorder...
  9. ncbi request reprint Role of peripheral serotonin in the regulation of central sleep apneas in rats
    D W Carley
    Department of Medicine, University of Illinois College of Medicine at Chicago, 60612, USA
    Chest 115:1397-401. 1999
    ....
  10. pmc Pharmacology of vagal afferent influences on disordered breathing during sleep
    David W Carley
    Center for Narcolepsy, Sleep and Health Research, University of Illinois, Chicago, IL 60612, USA
    Respir Physiol Neurobiol 164:197-203. 2008
    ....
  11. ncbi request reprint Adenosine A1 receptor agonist GR79236 suppresses apnea during all sleep stages in the rat
    D W Carley
    Department of Medicine, University of Illinois at Chicago College of Medicine, 60612, USA
    Sleep 20:1093-8. 1997
    ....
  12. ncbi request reprint Monoaminergic system lesions increase post-sigh respiratory pattern disturbance during sleep in rats
    J Saponjic
    Department of Medicine, University of Illinois, Chicago, IL 60612, USA
    Physiol Behav 90:1-10. 2007
    ..002). This reflected increased coupling between sighs and apneas, because neither the frequency nor the amplitude of spontaneous sighs was altered by PCA...
  13. ncbi request reprint Riluzole suppresses post-sigh, but not spontaneous apnoeas during sleep in rats
    M Radulovacki
    Department of Pharmacology, University of Illinois at Chicago, 60612, USA
    J Pharm Pharmacol 53:1555-9. 2001
    ..The drug (5.0 and 10.0 mg kg(-1)) also dose-dependently reduced wakefulness and increased sleep. It appears that glutamate, an excitatory neurotransmitter, plays a role in the genesis of the post-sigh apnoeas during REM sleep...
  14. ncbi request reprint Respiratory and electrocortical responses to acoustic stimulation
    D W Carley
    Department of Medicine, University of Illinois College of Medicine at Chicago, Chicago 60612, USA
    Sleep 19:S189-92. 1996
    ..This sensory stimulation represents a significant respiratory stimulus even when generalized arousal from sleep does not occur...
  15. ncbi request reprint Cardiopulmonary interactions following REM sleep deprivation in Sprague-Dawley rats
    M Radulovacki
    Department of Pharmacology, College of Medicine, University of Illinois at Chicago, 60612, USA
    Exp Neurol 145:371-5. 1997
    ..These cardiovascular changes coupled with the observed decreases in respiratory rate and minute ventilation suggest a further augmentation of baroreflexes following REM sleep deprivation...
  16. ncbi request reprint Pontine intertrigeminal region attenuates sleep apneas in rats
    Miodrag Radulovacki
    Department of Pharmacology, University of Illinois at Chicago, 60612, USA
    Sleep 27:383-7. 2004
    ..To determine whether the pontine intertrigeminal region (ITR), with recently described anatomic connections and an effect on vagally induced reflex apnea, has an impact on spontaneous sleep apneas in rats...
  17. ncbi request reprint Impact of intertrigeminal region AMPA receptor blockade on respiratory responses in rats
    Esma R Isenovic
    Center for Narcolepsy, Sleep and Health Research, Colleges of Nursing and Medicine, University of Illinois at Chicago M C 802, 845 S Damen Avenue, Chicago, IL 60612, United States
    Respir Physiol Neurobiol 158:39-44. 2007
    ..In contrast to kynurenic acid, antagonists to NMDA and AMPA receptors given separately did not potentiate the duration of reflex apnea...
  18. ncbi request reprint Intertrigeminal region attenuates reflex apnea and stabilizes respiratory pattern in rats
    Miodrag Radulovacki
    Department of Pharmacology, M C 868, University of Illinois at Chicago, 901 S Wolcott Ave, Chicago, IL 60612, USA
    Brain Res 975:66-72. 2003
    ..In addition, our data indicate that medullary circuits, independent of pontine structures, are sufficient to produce 5-HT induced reflex apnea...
  19. ncbi request reprint Modulation of respiratory pattern and upper airway muscle activity by the pedunculopontine tegmentum: role of NMDA receptors
    Jasna Saponjic
    Department of Medicine, University of Illinois, Chicago, IL, 60612, USA
    Sleep Breath 10:195-202. 2006
    ..For the first time, the present results suggest that respiratory rhythm and upper airway muscle tone are controlled by the activation of pedunculopontine tegmental nucleus NMDA receptors...
  20. ncbi request reprint An automated pontine-wave detection system
    Chao Li
    Department of Bioengineering, University of Illinois at Chicago, 60612, USA
    Sleep 26:613-8. 2003
    ....
  21. ncbi request reprint Effects of intertrigeminal region NMDA and non-NMDA receptors on respiratory responses in rats
    Miodrag Radulovacki
    Department of Pharmacology, M C 868, University of Illinois at Chicago, 835 S Wolcott Avenue, Chicago, IL 60612, USA
    Respir Physiol Neurobiol 156:40-6. 2007
    ..These data support the involvement of ITR non-NMDA receptors in modulation of reflex apnea per se, whereas NMDA receptors play a role in damping respiratory responses to transient disturbances...
  22. ncbi request reprint Serotonin and noradrenaline modulate respiratory pattern disturbances evoked by glutamate injection into the pedunculopontine tegmentum of anesthetized rats
    Jasna Saponjic
    Section of Respiratory and Critical Care Medicine, Department of Medicine MC 719, 840 South Wood Street, Chicago, Illinois 60612 7323, USA
    Sleep 28:560-70. 2005
    ..We hypothesized that 2 important neurotransmitters related to behavioral state control, serotonin and noradrenaline, could also be modulators of pedunculopontine tegmental nucleus (PPT)-induced respiratory dysrhythmia...
  23. ncbi request reprint Injection of glutamate into the pedunculopontine tegmental nuclei of anesthetized rat causes respiratory dysrhythmia and alters EEG and EMG power
    Jasna Saponjic
    Department of Medicine, Section of Pulmonary, Critical Care and Sleep Medicine, University of Illinois, Chicago, IL 60612, USA
    Sleep Breath 9:82-91. 2005
    ..Thus, we conclude that respiratory suppression produced by the local activation of PPT neurons may not necessarily be accompanied by an REM-sleep-like cortical state in this anesthetized model...
  24. ncbi request reprint Respiratory pattern modulation by the pedunculopontine tegmental nucleus
    Jasna Saponjic
    Department of Medicine, Section of Respiratory and Critical Care Medicine, University of Illinois at Chicago, 840 South Wood Street, Chicago, IL 60612 7323, USA
    Respir Physiol Neurobiol 138:223-37. 2003
    ..We conclude that glutamatergic stimulation of PPT has a significant impact on the brainstem respiratory pattern generator...
  25. ncbi request reprint Modulation of reflex and sleep related apnea by pedunculopontine tegmental and intertrigeminal neurons
    Miodrag Radulovacki
    Department of Pharmacology, University of Illinois at Chicago, M C 868, 901 S Wolcott Avenue, Chicago, IL 60612, USA
    Respir Physiol Neurobiol 143:293-306. 2004
    ..Although the exact central mechanisms of apnea cannot be determined from our studies to date, we postulate that reflex and sleep-related apneas in rats share some common brainstem pathways, which may include PPT and ITR...
  26. pmc Monotone Signal Segments Analysis as a novel method of breath detection and breath-to-breath interval analysis in rat
    Tijana Bojic
    School of Medicine, University of Belgrade, 11000 Belgrade, Serbia
    Respir Physiol Neurobiol 161:273-80. 2008
    ..MSSA represents a potentially valuable new tool for investigations of respiratory pattern control...

Research Grants10

  1. NEUROBIOLOGY OF SLEEP APNEA IN AGING
    David W Carley; Fiscal Year: 2010
    ..Extending the progress of the first funding cycle, these aims will provide important insights regarding the state-dependent mechanisms by which the PPT modulates respiratory pattern. ..
  2. NEUROBIOLOGY OF SLEEP APNEA IN AGING
    David Carley; Fiscal Year: 2007
    ..Extending the progress of the first funding cycle, these aims will provide important insights regarding the state-dependent mechanisms by which the PPT modulates respiratory pattern. ..
  3. NEUROBIOLOGY OF SLEEP APNEA IN AGING
    David Carley; Fiscal Year: 2002
    ..These manipulations in old and young patients, controls, and rats will provide a comprehensive approach to define the mechanisms and importance of brainstem phasic event-induced respiratory instability in aging. ..
  4. NEUROBIOLOGY OF SLEEP APNEA IN AGING
    David Carley; Fiscal Year: 2006
    ..Extending the progress of the first funding cycle, these aims will provide important insights regarding the state-dependent mechanisms by which the PPT modulates respiratory pattern. ..
  5. NEUROBIOLOGY OF SLEEP APNEA IN AGING
    David Carley; Fiscal Year: 2009
    ..Extending the progress of the first funding cycle, these aims will provide important insights regarding the state-dependent mechanisms by which the PPT modulates respiratory pattern. ..
  6. NEUROBIOLOGY OF SLEEP APNEA IN AGING
    David Carley; Fiscal Year: 2000
    ..These manipulations in old and young patients, controls, and rats will provide a comprehensive approach to define the mechanisms and importance of brainstem phasic event-induced respiratory instability in aging. ..
  7. NEUROBIOLOGY OF SLEEP APNEA IN AGING
    David Carley; Fiscal Year: 2003
    ..These manipulations in old and young patients, controls, and rats will provide a comprehensive approach to define the mechanisms and importance of brainstem phasic event-induced respiratory instability in aging. ..
  8. NEUROBIOLOGY OF SLEEP APNEA IN AGING
    David Carley; Fiscal Year: 2001
    ..These manipulations in old and young patients, controls, and rats will provide a comprehensive approach to define the mechanisms and importance of brainstem phasic event-induced respiratory instability in aging. ..
  9. NEUROBIOLOGY OF SLEEP APNEA IN AGING
    David Carley; Fiscal Year: 2009
    ..Extending the progress of the first funding cycle, these aims will provide important insights regarding the state-dependent mechanisms by which the PPT modulates respiratory pattern. ..