Robert L Carithers

Summary

Affiliation: University of Washington
Country: USA

Publications

  1. ncbi request reprint Diagnostic testing for hepatitis C
    R L Carithers
    University of Washington, Seattle 98195 6174, USA
    Semin Liver Dis 20:159-71. 2000
  2. ncbi request reprint Primary biliary cirrhosis: specific treatment
    Robert L Carithers
    University of Washington, 1959 NE Pacific Street, Box 356174, Seattle, WA 98195 6174, USA
    Clin Liver Dis 7:923-39. 2003
  3. pmc Proteome and computational analyses reveal new insights into the mechanisms of hepatitis C virus-mediated liver disease posttransplantation
    Deborah L Diamond
    Department of Microbiology, University of Washington School of Medicine, Seattle, WA 98195 8070, USA
    Hepatology 56:28-38. 2012
  4. pmc Genetic diversity of hepatitis C virus predicts recurrent disease after liver transplantation
    Hui Li
    Department of Laboratory Medicine, University of Washington Medical Center, Seattle, Washington, USA
    Virology 402:248-55. 2010
  5. pmc Early transcriptional programming links progression to hepatitis C virus-induced severe liver disease in transplant patients
    Angela L Rasmussen
    Department of Microbiology, University of Washington School of Medicine, Seattle, WA 98195, USA
    Hepatology 56:17-27. 2012
  6. ncbi request reprint Proteomic profiling of human liver biopsies: hepatitis C virus-induced fibrosis and mitochondrial dysfunction
    Deborah L Diamond
    Department of Microbiology, University of Washington, Seattle, WA 98195 8070, USA
    Hepatology 46:649-57. 2007
  7. ncbi request reprint Identification of a specific gene expression pattern associated with HCV-induced pathogenesis in HCV- and HCV/HIV-infected individuals
    Kathie Anne Walters
    Department of Microbiology, School of Medicine, University of Washington, Box 358070, Seattle, WA 98195 8070, USA
    Virology 350:453-64. 2006
  8. ncbi request reprint Productive replication of hepatitis C virus in perihepatic lymph nodes in vivo: implications of HCV lymphotropism
    Sampa Pal
    Department of Laboratory Medicine, University of Washington Medical Center, Seattle, Washington 98104, USA
    Gastroenterology 130:1107-16. 2006
  9. pmc Hepatitis C virus induces oxidative stress, DNA damage and modulates the DNA repair enzyme NEIL1
    Sampa Pal
    Department of Laboratory Medicine, University of Washington, Seattle, Washington 98195 7110 USA
    J Gastroenterol Hepatol 25:627-34. 2010
  10. pmc Investigation of putative multisubtype hepatitis C virus infections in vivo by heteroduplex mobility analysis of core/envelope subgenomes
    Hui Li
    Department of Laboratory Medicine, University of Washington Medical Center, Seattle, Washington, USA
    J Virol 82:7524-32. 2008

Detail Information

Publications30

  1. ncbi request reprint Diagnostic testing for hepatitis C
    R L Carithers
    University of Washington, Seattle 98195 6174, USA
    Semin Liver Dis 20:159-71. 2000
    ..The various tests for hepatitis C are expensive and have their limitations. However, selective use of these assays has greatly improved the care of patients with chronic hepatitis C...
  2. ncbi request reprint Primary biliary cirrhosis: specific treatment
    Robert L Carithers
    University of Washington, 1959 NE Pacific Street, Box 356174, Seattle, WA 98195 6174, USA
    Clin Liver Dis 7:923-39. 2003
    ..Trials to unequivocally demonstrate the efficacy of new agents will have to be extremely well designed, however, and will require large numbers of patients followed for an extended period of time...
  3. pmc Proteome and computational analyses reveal new insights into the mechanisms of hepatitis C virus-mediated liver disease posttransplantation
    Deborah L Diamond
    Department of Microbiology, University of Washington School of Medicine, Seattle, WA 98195 8070, USA
    Hepatology 56:28-38. 2012
    ..Computational modeling approaches further highlight a potentially important link between HCV-associated oxidative stress and epigenetic regulatory mechanisms impacting on liver fibrogenesis...
  4. pmc Genetic diversity of hepatitis C virus predicts recurrent disease after liver transplantation
    Hui Li
    Department of Laboratory Medicine, University of Washington Medical Center, Seattle, Washington, USA
    Virology 402:248-55. 2010
    ..004). Meanwhile, pre-transplant genetic differences between serum and liver were related to a higher likelihood of development of mild recurrent disease after transplant (p=0.039)...
  5. pmc Early transcriptional programming links progression to hepatitis C virus-induced severe liver disease in transplant patients
    Angela L Rasmussen
    Department of Microbiology, University of Washington School of Medicine, Seattle, WA 98195, USA
    Hepatology 56:17-27. 2012
    ..Additionally, a common precursor state for different severe clinical outcomes was identified...
  6. ncbi request reprint Proteomic profiling of human liver biopsies: hepatitis C virus-induced fibrosis and mitochondrial dysfunction
    Deborah L Diamond
    Department of Microbiology, University of Washington, Seattle, WA 98195 8070, USA
    Hepatology 46:649-57. 2007
    ....
  7. ncbi request reprint Identification of a specific gene expression pattern associated with HCV-induced pathogenesis in HCV- and HCV/HIV-infected individuals
    Kathie Anne Walters
    Department of Microbiology, School of Medicine, University of Washington, Box 358070, Seattle, WA 98195 8070, USA
    Virology 350:453-64. 2006
    ..Importantly, the pattern of gene expression observed in EGE (+) patients has similarities to patients who developed fibrosis within 1 year of receiving a liver transplant...
  8. ncbi request reprint Productive replication of hepatitis C virus in perihepatic lymph nodes in vivo: implications of HCV lymphotropism
    Sampa Pal
    Department of Laboratory Medicine, University of Washington Medical Center, Seattle, Washington 98104, USA
    Gastroenterology 130:1107-16. 2006
    ..The pathogenesis of chronic hepatitis C is poorly understood. This study examines the ability of hepatitis C virus (HCV) to infect, replicate in, and produce progeny virus from perihepatic lymph nodes in vivo...
  9. pmc Hepatitis C virus induces oxidative stress, DNA damage and modulates the DNA repair enzyme NEIL1
    Sampa Pal
    Department of Laboratory Medicine, University of Washington, Seattle, Washington 98195 7110 USA
    J Gastroenterol Hepatol 25:627-34. 2010
    ..In the current study we examined the induction of reactive oxygen species (ROS) resulting from HCV infection and evaluated its effect on the host DNA damage and repair machinery...
  10. pmc Investigation of putative multisubtype hepatitis C virus infections in vivo by heteroduplex mobility analysis of core/envelope subgenomes
    Hui Li
    Department of Laboratory Medicine, University of Washington Medical Center, Seattle, Washington, USA
    J Virol 82:7524-32. 2008
    ..In summary, a large proportion of mixed-genotype and switching-genotype patterns generated by 5'-UTR analysis were not reproducible using the HMA approach, emphasizing the need for additional study...
  11. ncbi request reprint Hepatitis C virus-specific cytolytic T cell responses after antiviral therapy
    Chihiro Morishima
    University of Washington, School of Medicine, Seattle, WA 98195, USA
    Clin Immunol 108:211-20. 2003
    ....
  12. ncbi request reprint Liver transplantation at the extremes of the body mass index
    Andre A S Dick
    Division of Transplantation, Department of Surgery, University of Washington Medical Center, Seattle, WA, USA
    Liver Transpl 15:968-77. 2009
    ..In conclusion, liver transplantation holds increased risk for patients at the extremes of BMI. Identifying these patients and instituting aggressive new policies may improve outcomes. Liver Transpl 15:968-977, 2009. (c) 2009 AASLD...
  13. pmc Use of an automated clinical management system improves outpatient immunosuppressive care following liver transplantation
    Esther S Park
    University of Washington School of Medicine, Seattle, Washington, USA
    J Am Med Inform Assoc 17:396-402. 2010
    ..We investigated whether use of an automated clinical management system in our liver transplant program would improve clinical outcomes in managing transplant recipients' immunosuppressive medications...
  14. ncbi request reprint Gene expression patterns that correlate with hepatitis C and early progression to fibrosis in liver transplant recipients
    Maria W Smith
    Department of Microbiology, School of Medicine, University of Washington, Seattle, Washington 98195 8070, USA
    Gastroenterology 130:179-87. 2006
    ..Our goals were to identify molecular processes influencing the liver disease progression and to find potential gene markers of early fibrosis...
  15. doi request reprint Liver transplantation for hepatocellular carcinoma: impact of the MELD allocation system and predictors of survival
    George N Ioannou
    Division of Gastroenterology, Department of Medicine, Veterans Affairs Puget Sound Health Care System, Seattle, Washington, USA
    Gastroenterology 134:1342-51. 2008
    ..We aimed to determine the impact of this system on liver transplantation for HCC...
  16. doi request reprint Should liver transplantation in patients with model for end-stage liver disease scores <or= 14 be avoided? A decision analysis approach
    James D Perkins
    Division of Transplantation, Department of Surgery, University of Washington, Seattle, WA 98195, USA
    Liver Transpl 15:242-54. 2009
    ..Our analysis supports changing the national liver allocation policy to not allow liver transplantation for patients with MELD <or= 14...
  17. pmc Proteome analysis of liver cells expressing a full-length hepatitis C virus (HCV) replicon and biopsy specimens of posttransplantation liver from HCV-infected patients
    Jon M Jacobs
    Department of Microbiology, University of Washington, Box 358070, Seattle, WA 98195 8070, USA
    J Virol 79:7558-69. 2005
    ....
  18. ncbi request reprint Recipient and donor factors influence the incidence of graft-vs.-host disease in liver transplant patients
    Edie Y Chan
    Division of Transplantation, Department of Surgery, University of Washington, Seattle, WA 98195, USA
    Liver Transpl 13:516-22. 2007
    ..037). In conclusion, we have identified liver transplant patients with AIH or the combination of ALD, HCC, and glucose intolerance who receive a steatotic donor liver as being at high risk for developing GVHD...
  19. doi request reprint The HALOS-ND model: a step in the journey of predicting hospital length of stay after liver transplantation
    Kartik R Krishnan
    Internal Medicine, University of Washington, Seattle, WA, USA
    Clin Transplant 27:809-22. 2013
    ..These predictions would help predict the factors most likely to prolong LOS, inform resource allocation, and provide patients with more specific predictions of their LOS following transplantation. ..
  20. ncbi request reprint Hepatitis C virus and liver disease: global transcriptional profiling and identification of potential markers
    Maria W Smith
    Department of Microbiology, School of Medicine, University of Washington, Seattle, WA 98195, USA
    Hepatology 38:1458-67. 2003
    ..In conclusion, our microarray analysis identified several potential gene markers of HCV-associated liver disease and contributed to our rapidly expanding database of experiments describing HCV pathogenesis...
  21. ncbi request reprint Is central obesity associated with cirrhosis-related death or hospitalization? A population-based, cohort study
    George N Ioannou
    Health Services Research and Development and Northwest Hepatitis C Resource Centers, Veterans Affairs Puget Sound System, Seattle, Washington, USA
    Clin Gastroenterol Hepatol 3:67-74. 2005
    ..We aimed to determine the interaction between body fat distribution (central versus peripheral) and increased body mass index (BMI) with regards to the risk of cirrhosis-related death or hospitalization...
  22. ncbi request reprint Using root cause analysis to improve survival in a liver transplant program
    James D Perkins
    Division of Transplantation, Department of Surgery, University of Washington, Seattle, Washington 98195, USA
    J Surg Res 129:6-16. 2005
    ..86%, P = 0.23) and patient (80.61%, P = 0.016) survivals after liver transplantation were lower than our expected rates (graft 81.89% and patient 88.3%), according to the U.S. Scientific Registry of Transplant Recipients (SRTR)...
  23. pmc Dynamics of hepatitis C virus replication in human liver
    Ming Chang
    Departments of Laboratory Medicine, University of Washington Medical Center, Seattle, WA, USA
    Am J Pathol 163:433-44. 2003
    ..Lower viral clearance rates in circulating blood may explain the phenomenon of increased serum titers of viral RNA in posttransplant immunosuppressed patients...
  24. ncbi request reprint Transiently altered acetaminophen metabolism after liver transplantation
    Jeong M Park
    Department of Pharmacy, University of Washington, Seattle, WA, USA
    Clin Pharmacol Ther 73:545-53. 2003
    ..Alterations in drug metabolism occur after organ transplantation. This study was designed to characterize acetaminophen disposition during the first 6 months after liver transplantation...
  25. ncbi request reprint AASLD practice guidelines: Evaluation of the patient for liver transplantation
    Karen F Murray
    Division of Gastroenterology, University of Washington School of Medicine, Seattle, WA 98195 6174, USA
    Hepatology 41:1407-32. 2005
  26. pmc Prolonged follow-up of patients in the U.S. multicenter trial of ursodeoxycholic acid for primary biliary cirrhosis
    Burton Combes
    University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 9151, USA
    Am J Gastroenterol 99:264-8. 2004
    ....
  27. ncbi request reprint Methotrexate (MTX) plus ursodeoxycholic acid (UDCA) in the treatment of primary biliary cirrhosis
    Burton Combes
    The University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390 9151, USA
    Hepatology 42:1184-93. 2005
    ..In conclusion, methotrexate when added to UDCA for a median period of 7.6 years had no effect on the course of PBC treated with UDCA alone...
  28. ncbi request reprint A multicenter study of recombinant human interleukin 12 for the treatment of chronic hepatitis C virus infection in patients nonresponsive to previous therapy
    Paul J Pockros
    Division of Gastroenterology and Hepatology, Scripps Clinic, La Jolla, CA, USA
    Hepatology 37:1368-74. 2003
    ..In conclusion, IL-12 as monotherapy at the doses used in this trial for chronic hepatitis C has low efficacy, was poorly tolerated, and is unlikely to provide an alternative to conventional IFN-based therapy...
  29. ncbi request reprint Corticosteroids improve short-term survival in patients with severe alcoholic hepatitis (AH): individual data analysis of the last three randomized placebo controlled double blind trials of corticosteroids in severe AH
    Philippe Mathurin
    Hopital Antoine Beclere, Clamart, France
    J Hepatol 36:480-7. 2002
    ....
  30. ncbi request reprint Liver transplantation for erythropoietic protoporphyria liver disease
    Brendan M McGuire
    Department of Medicine, University of Alabama at Birmingham, 1530 Third Avenue South, Birmingham, AL 35294 0005, USA
    Liver Transpl 11:1590-6. 2005
    ..In conclusion, the 5-year patient survival rate in patients transplanted for EPP liver disease is good, but the recurrence of EPP liver disease appears to diminish long term graft and patient survival...