ROBERT MUNSON CAREY

Summary

Affiliation: University of Virginia
Country: USA

Publications

  1. ncbi request reprint Aldosterone and cardiovascular disease
    Robert M Carey
    Division of Endocrinology and Metabolism, Department of Medicine, University of Virginia Health System, Charlottesville, Virginia 22908 1414, USA
    Curr Opin Endocrinol Diabetes Obes 17:194-8. 2010
  2. doi request reprint Role of angiotensin AT(2) receptors in natriuresis: Intrarenal mechanisms and therapeutic potential
    Robert M Carey
    Division of Endocrinology and Metabolism, Department of Medicine, University of Virginia Health System, Charlottesville, VA 22908, USA
    Clin Exp Pharmacol Physiol 40:527-34. 2013
  3. pmc Salt sensitivity of blood pressure is associated with polymorphisms in the sodium-bicarbonate cotransporter
    Robert M Carey
    Department of Medicine, University of Virginia Health System, Charlottesville, VA 22908 1414, USA
    Hypertension 60:1359-66. 2012
  4. doi request reprint Primary aldosteronism
    Robert M Carey
    Division of Endocrinology and Metabolism, Department of Medicine, University of Virginia Health System, Charlottesville, Virginia 22908 1414, USA
    J Surg Oncol 106:575-9. 2012
  5. doi request reprint Intrarenal angiotensin III is the predominant agonist for proximal tubule angiotensin type 2 receptors
    Brandon A Kemp
    Division of Endocrinology and Metabolism, Department of Medicine, University of Virginia School of Medicine, Charlottesville, VA, USA
    Hypertension 60:387-95. 2012
  6. ncbi request reprint Should we employ combination ACEI and ARB therapy in primary hypertension?
    Robert M Carey
    Department of Medicine, University of Virginia School of Medicine, PO Box 801414, Charlottesville, VA 22908 1414, USA
    Curr Hypertens Rep 8:101-2. 2006
  7. doi request reprint Primary aldosteronism
    Robert M Carey
    Division of Endocrinology and Metabolism, Department of Medicine, University of Virginia Health System, Charlottesville, VA, USA
    Horm Res 71:8-12. 2009
  8. ncbi request reprint Localization of the dopamine D1 receptor protein in the human heart and kidney
    R Ozono
    Department of Medicine, University of Virginia Health Sciences Center, Charlottesville 22908, USA
    Hypertension 30:725-9. 1997
  9. doi request reprint Angiotensin AT2 receptors: control of renal sodium excretion and blood pressure
    Robert M Carey
    Division of Endocrinology and Metabolism, Department of Medicine, University of Virginia Health Sciences Center, Charlottesville, VA 22901, USA
    Trends Endocrinol Metab 19:84-7. 2008
  10. ncbi request reprint Cardiovascular and renal regulation by the angiotensin type 2 receptor: the AT2 receptor comes of age
    Robert M Carey
    Division of Endocrinology and Metabolism, Department of Medicine, University of Virginia School of Medicine, Charlottesville 22908, USA
    Hypertension 45:840-4. 2005

Research Grants

  1. Renal AT2 Receptors in Hypertension
    ROBERT MUNSON CAREY; Fiscal Year: 2010
  2. PRESSURE NATRIURESIS MEDIATED BY EXTRACELLULAR cGMP
    Robert Carey; Fiscal Year: 2009
  3. Natriuretic mechanisms of AT2 receptors
    Robert Carey; Fiscal Year: 2009
  4. RESEARCH TRAINING IN NEUROENDOCRINOLOGY
    Robert Carey; Fiscal Year: 2007
  5. PRESSURE NATRIURESIS MEDIATED BY EXTRACELLULAR cGMP
    Robert Carey; Fiscal Year: 2007
  6. AT2 RECEPTORS IN BLOOD PRESSURE AND RENAL FUNCTION
    Robert Carey; Fiscal Year: 2004
  7. AT2 RECEPTOR MECHANISMS IN ANG II DEPENDENT HYPERTENSION
    Robert Carey; Fiscal Year: 2001
  8. Natriuretic mechanisms of AT2 receptors
    ROBERT MUNSON CAREY; Fiscal Year: 2010

Collaborators

Detail Information

Publications65

  1. ncbi request reprint Aldosterone and cardiovascular disease
    Robert M Carey
    Division of Endocrinology and Metabolism, Department of Medicine, University of Virginia Health System, Charlottesville, Virginia 22908 1414, USA
    Curr Opin Endocrinol Diabetes Obes 17:194-8. 2010
    ....
  2. doi request reprint Role of angiotensin AT(2) receptors in natriuresis: Intrarenal mechanisms and therapeutic potential
    Robert M Carey
    Division of Endocrinology and Metabolism, Department of Medicine, University of Virginia Health System, Charlottesville, VA 22908, USA
    Clin Exp Pharmacol Physiol 40:527-34. 2013
    ....
  3. pmc Salt sensitivity of blood pressure is associated with polymorphisms in the sodium-bicarbonate cotransporter
    Robert M Carey
    Department of Medicine, University of Virginia Health System, Charlottesville, VA 22908 1414, USA
    Hypertension 60:1359-66. 2012
    ..2 × 10(-5)]; rs1017783 [P=1.1 × 10(-4)]). In conclusion, SLC4A5 variants are strongly associated with salt sensitivity of blood pressure in 2 separate white populations...
  4. doi request reprint Primary aldosteronism
    Robert M Carey
    Division of Endocrinology and Metabolism, Department of Medicine, University of Virginia Health System, Charlottesville, Virginia 22908 1414, USA
    J Surg Oncol 106:575-9. 2012
    ..Approximately 50% of patients with primary aldosteronism will have a unilateral aldosterone-producing adenoma; laparoscopic adrenalectomy results in cure of hypertension in 60% and improvement in blood pressure control in the remainder...
  5. doi request reprint Intrarenal angiotensin III is the predominant agonist for proximal tubule angiotensin type 2 receptors
    Brandon A Kemp
    Division of Endocrinology and Metabolism, Department of Medicine, University of Virginia School of Medicine, Charlottesville, VA, USA
    Hypertension 60:387-95. 2012
    ....
  6. ncbi request reprint Should we employ combination ACEI and ARB therapy in primary hypertension?
    Robert M Carey
    Department of Medicine, University of Virginia School of Medicine, PO Box 801414, Charlottesville, VA 22908 1414, USA
    Curr Hypertens Rep 8:101-2. 2006
  7. doi request reprint Primary aldosteronism
    Robert M Carey
    Division of Endocrinology and Metabolism, Department of Medicine, University of Virginia Health System, Charlottesville, VA, USA
    Horm Res 71:8-12. 2009
    ..Compared with normotensive subjects, patients with primary aldosteronism have a 4.2-fold greater risk of stroke, a 6.5-fold greater risk of myocardial infarction and a 12.1-fold greater risk of atrial fibrillation...
  8. ncbi request reprint Localization of the dopamine D1 receptor protein in the human heart and kidney
    R Ozono
    Department of Medicine, University of Virginia Health Sciences Center, Charlottesville 22908, USA
    Hypertension 30:725-9. 1997
    ..The similar distribution of this subtype receptor in the human heart and kidney to that in the rat supports the possible (patho)physiological significance of the peripheral dopamine system in humans...
  9. doi request reprint Angiotensin AT2 receptors: control of renal sodium excretion and blood pressure
    Robert M Carey
    Division of Endocrinology and Metabolism, Department of Medicine, University of Virginia Health Sciences Center, Charlottesville, VA 22901, USA
    Trends Endocrinol Metab 19:84-7. 2008
    ..In addition, AT2 receptor activation suppresses renin biosynthesis and release at renal juxtaglomerular cells. Therefore, AT2 receptors are potential therapeutic targets in hypertension...
  10. ncbi request reprint Cardiovascular and renal regulation by the angiotensin type 2 receptor: the AT2 receptor comes of age
    Robert M Carey
    Division of Endocrinology and Metabolism, Department of Medicine, University of Virginia School of Medicine, Charlottesville 22908, USA
    Hypertension 45:840-4. 2005
  11. ncbi request reprint The intrarenal renin-angiotensin system and diabetic nephropathy
    Robert M Carey
    Division of Endocrinology and Metabolism, Department of Medicine, University of Virginia School of Medicine, Box 801414, University of Virginia Health System, Charlottesville, VA 22908 1414, USA
    Trends Endocrinol Metab 14:274-81. 2003
    ..A rat model of accelerated diabetic nephropathy is the (mREN-2) 27 renin transgenic rat treated with streptozotocin in which both the intrarenal and extrarenal RAS is activated...
  12. ncbi request reprint Newly recognized components of the renin-angiotensin system: potential roles in cardiovascular and renal regulation
    Robert M Carey
    Division of Endocrinology and Metabolism, Department of Medicine, University of Virginia Health System, Charlottesville, Virginia 22908, USA
    Endocr Rev 24:261-71. 2003
    ..The role of the RAS in the regulation of cardiovascular and renal function is reviewed and discussed in light of these newly recognized components...
  13. ncbi request reprint Role of the angiotensin type 2 receptor in the regulation of blood pressure and renal function
    R M Carey
    Department of Medicine, University of Virginia School of Medicine, Charlottesville, VA 22908, USA
    Hypertension 35:155-63. 2000
    ..The AT(2) receptor appears to play a counterregulatory protective role in the regulation of blood pressure and sodium excretion that opposes the AT(1) receptor...
  14. ncbi request reprint Role of the angiotensin AT2 receptor in blood pressure regulation and therapeutic implications
    R M Carey
    Department of Medicine, University of Virginia School of Medicine, Charlottesville 22908 0793, USA
    Am J Hypertens 14:98S-102S. 2001
    ..Several recent studies suggest that AT2 receptors may mediate vasodilation and hypotension. The AT2 receptor represents a potential therapeutic target for agonist action and a candidate molecule in the pathophysiology of hypertension...
  15. ncbi request reprint Angiotensin type 2 receptor-mediated hypotension in angiotensin type-1 receptor-blocked rats
    R M Carey
    Department of Medicine, University of Virginia Health System, Charlottesville 22908, USA
    Hypertension 38:1272-7. 2001
    ..The results strongly suggest that the AT(2) receptor induces a systemic vasodilator response mediated by NO that counterbalances the vasoconstrictor action of Ang II at the AT(1) receptor...
  16. pmc Mechanisms of dopamine D(1) and angiotensin type 2 receptor interaction in natriuresis
    Shetal H Padia
    Division of Endocrinology and Metabolism, Department of Internal Medicine, University of Virginia Health System, Charlottesville, VA 22908 1414, USA
    Hypertension 59:437-45. 2012
    ..These studies provide novel insights regarding the mechanisms whereby renal D(1)Rs and AT(2)Rs act in concert to promote sodium excretion in vivo...
  17. doi request reprint Adrenal disease update 2011
    Robert M Carey
    Division of Endocrinology and Metabolism, Department of Medicine, University of Virginia Health System, Charlottesville, Virginia 22908 1414, USA
    J Clin Endocrinol Metab 96:3583-91. 2011
    ..An effort was made to include both adrenal cortical and medullary disorders...
  18. doi request reprint Overview of endocrine systems in primary hypertension
    Robert M Carey
    Division of Endocrinology and Metabolism, Department of Medicine, University of Virginia Health System, PO Box 801414, Charlottesville, VA 22908 1414, USA
    Endocrinol Metab Clin North Am 40:265-77, vii. 2011
    ..Because the vast majority of HT is primary, this article focuses on the major endocrine systems, the RAS, aldosterone, and the SNS, that play a prominent role in the pathogenesis of HT...
  19. ncbi request reprint Angiotensin AT2 receptors directly stimulate renal nitric oxide in bradykinin B2-receptor-null mice
    Peter M Abadir
    Department of Medicine, University of Virginia School of Medicine, Charlottesville, USA
    Hypertension 42:600-4. 2003
    ..We conclude that NO can be produced by 2 alternative pathways: directly through the AT2 receptor or indirectly from AT2 receptor stimulation of bradykinin via the B2 receptor...
  20. ncbi request reprint Renal nitric oxide production is decreased in diabetic rats and improved by AT1 receptor blockade
    Alaa S Awad
    Department of Medicine, University of Virginia, Charlottesville, Virginia, USA
    J Hypertens 22:1571-7. 2004
    ..Lack of nitric oxide production may exacerbate these complications. We hypothesized that diabetes decreases renal nitric oxide (NO) production, an effect that is reversed via inhibition of angiotensin subtype-1 receptor...
  21. ncbi request reprint Intrarenal aminopeptidase N inhibition augments natriuretic responses to angiotensin III in angiotensin type 1 receptor-blocked rats
    Shetal H Padia
    Division of Endocrinology and Metabolism, University of Virginia Health System, Charlottesville, VA 22908 1414, USA
    Hypertension 49:625-30. 2007
    ..9; P=0.0001). Aminopeptidase N inhibition augmented the natriuretic response to angiotensin III, suggesting that angiotensin III is a major agonist of angiotensin type 2 receptor-induced natriuresis...
  22. ncbi request reprint Interaction between bradykinin subtype 2 and angiotensin II type 2 receptors during post-MI left ventricular remodeling
    David C Isbell
    Cardiovascular Division, Department of Medicine, University of Virginia Health System, 1215 Lee Street, Charlottesville, VA 22908, USA
    Am J Physiol Heart Circ Physiol 293:H3372-8. 2007
    ..However, B(2)R does appear to have a role in the smaller cavity size and hyperdynamic function observed at baseline in AT(2)TG mice and in limiting collagen deposition during postinfarct remodeling...
  23. ncbi request reprint Renal interstitial guanosine cyclic 3', 5'-monophosphate mediates pressure-natriuresis via protein kinase G
    Xiao Hong Jin
    Department of Medicine, University of Virginia School of Medicine, Charlottesville, VA 22908 1414, USA
    Hypertension 43:1133-9. 2004
    ..In conclusion, pressure-natriuresis is mediated by RI cGMP and a PKG signaling pathway in target renal proximal tubule cells...
  24. ncbi request reprint Renal angiotensin type 2 receptors mediate natriuresis via angiotensin III in the angiotensin II type 1 receptor-blocked rat
    Shetal H Padia
    Division of Endocrinology and Metabolism, Department of Internal Medicine, University of Virginia Health System, Charlottesville, VA 22908 1414, USA
    Hypertension 47:537-44. 2006
    ..AT2 receptor activation via Ang III, but not via Ang II, mediates the natriuretic response in the presence of systemic AT1 receptor blockade...
  25. ncbi request reprint Intrarenal dopamine D1-like receptor stimulation induces natriuresis via an angiotensin type-2 receptor mechanism
    Leslie J Salomone
    Division of Endocrinology and Metabolism, Department of Medicine, University of Virginia Health System, Charlottesville, VA 22908, USA
    Hypertension 49:155-61. 2007
    ....
  26. pmc Angiotensin II type 1 and type 2 receptors regulate basal skeletal muscle microvascular volume and glucose use
    Weidong Chai
    Division of Endocrinology and Metabolism, Department of Medicine, University of Virginia Health System, Charlottesville, VA 22908, USA
    Hypertension 55:523-30. 2010
    ..Pharmacological manipulation of the balance of AT(1)R and AT(2)R activity affords the potential to improve glucose metabolism...
  27. ncbi request reprint Increased renal production of angiotensin II and thromboxane B2 in conscious diabetic rats
    Alaa S Awad
    Department of Medicine, University of Virginia, Charlottesville, Virginia 22908, USA
    Am J Hypertens 18:544-8. 2005
    ..We hypothesized that diabetes increases renal production of TXB2 through stimulation of angiotensin type-1 receptor...
  28. doi request reprint Intact microtubules are required for natriuretic responses to nitric oxide and increased renal perfusion pressure
    Jennifer Park
    Division of Endocrinology and Metabolism, Department of Medicine, University of Virginia Health System, Charlottesville, VA 22908 1414, USA
    Hypertension 51:494-9. 2008
    ..These observations indicate that a functioning microtubulin network is required for the transport of cGMP into the extracellular space to modulate NO- and pressure-induced natriuresis...
  29. ncbi request reprint Extracellular renal guanosine cyclic 3'5'-monophosphate modulates nitric oxide and pressure-induced natriuresis
    Farah Ahmed
    Division of Endocrinology and Metabolism, Department of Medicine, University of Virginia Health Sciences Center, Charlottesville, USA
    Hypertension 50:958-63. 2007
    ..Extracellular cGMP modulates NO- and pressure-induced natriuresis...
  30. ncbi request reprint Angiotensin II type 2 receptor overexpression preserves left ventricular function after myocardial infarction
    Zequan Yang
    Department of Medicine and the Cardiovascular Research Center, University of Virginia Health System, Charlottesville 22908, USA
    Circulation 106:106-11. 2002
    ..We hypothesized that cardiac AT2-R overexpression in transgenic (TG) mice would attenuate remodeling after myocardial infarction (MI)...
  31. ncbi request reprint Angiotensin subtype-2 receptors inhibit renin biosynthesis and angiotensin II formation
    Helmy M Siragy
    Department of Medicine, University of Virginia Health System, Charlottesville, VA, USA
    Hypertension 45:133-7. 2005
    ..These data demonstrate for the first time to our knowledge that AT2 receptors regulate the renin-angiotensin system activity via inhibition of renin synthesis...
  32. ncbi request reprint Conversion of renal angiotensin II to angiotensin III is critical for AT2 receptor-mediated natriuresis in rats
    Shetal H Padia
    Division of Endocrinology and Metabolism, Department of Internal Medicine, University of Virginia Health System, Charlottesville, VA 22908 1414, USA
    Hypertension 51:460-5. 2008
    ..These data demonstrate that RI addition of PC-18 to Ang II enables natriuresis mediated by the AT(2)R, and that conversion of Ang II to Ang III is critical for this response...
  33. pmc Role of the intrarenal renin-angiotensin-aldosterone system in chronic kidney disease
    Helmy M Siragy
    Department of Medicine, University of Virginia Health System, Charlottesville, USA
    Am J Nephrol 31:541-50. 2010
    ..We also discuss additional strategies to inhibit the RAAS more effectively and the potential impact of direct renin inhibition on the prevention and management of CKD...
  34. pmc Intrarenal aminopeptidase N inhibition restores defective angiontesin II type 2-mediated natriuresis in spontaneously hypertensive rats
    Shetal H Padia
    Division of Endocrinology and Metabolism, Department of Internal Medicine, University of Virginia Health System, Charlottesville, VA 22908 1414, USA
    Hypertension 55:474-80. 2010
    ..Thus, increased renal proximal tubule sodium retention is observed before the onset of hypertension in SHRs, and inhibition of the metabolism of Ang III ameliorates this pathophysiologic defect in sodium excretion...
  35. ncbi request reprint NO and cGMP mediate angiotensin AT2 receptor-induced renal renin inhibition in young rats
    Helmy M Siragy
    Department of Medicine, University of Virginia Health System, Charlottesville, VA 22908 1409, USA
    Am J Physiol Regul Integr Comp Physiol 293:R1461-7. 2007
    ..Reversal of the PD effects by SNAP and SNAP effects by ODQ confirms that NO and cGMP mediate the AT(2) receptor inhibition of renal renin production...
  36. ncbi request reprint Update on the role of the AT2 receptor
    Robert M Carey
    Division of Endocrinology and Metabolism, Department of Medicine, University of Virginia Health System, Charlottesville, VA 229008, USA
    Curr Opin Nephrol Hypertens 14:67-71. 2005
    ..While the majority of angiotensin II actions are mediated via the AT1 receptor, evidence has accumulated that the AT2 receptor opposes the AT1 receptor, especially by inducing vasodilation instead of vasoconstriction...
  37. pmc Intrarenal angiotensin III infusion induces natriuresis and angiotensin type 2 receptor translocation in Wistar-Kyoto but not in spontaneously hypertensive rats
    Shetal H Padia
    Division of Endocrinology and Metabolism, Department of Internal Medicine, University of Virginia Health System, Charlottesville, VA 22908 1414, USA
    Hypertension 53:338-43. 2009
    ..Identical manipulations fail to induce natriuresis or AT(2)R translocation in SHRs, suggesting that defects in AT(2)R-mediated natriuresis and trafficking may be important to the development of hypertension in SHRs...
  38. ncbi request reprint Differences in AT2 -receptor stimulation between AT1 -receptor blockers valsartan and losartan quantified by renal interstitial fluid cGMP
    Helmy M Siragy
    Department of Internal Medicine, University of Virginia Health System, Charlottesville, Virginia 22908, USA
    J Hypertens 20:1157-63. 2002
    ..The present study employed an animal model to demonstrate angiotensin II-receptor blocker-specific effects and to quantify these differences by comparing two common agents, losartan and valsartan...
  39. ncbi request reprint Nitric oxide mediates benefits of angiotensin II type 2 receptor overexpression during post-infarct remodeling
    Christina M Bove
    University of Virginia Health System, Departments of Medicine and Radiology, Lee Street, Box 800170, Charlottesville, VA 22908, USA
    Hypertension 43:680-5. 2004
    ..Noninfarcted region interstitial collagen was similar between groups. Thus, the NO pathway may mediate much of the benefits of cardiac AT(2)-R overexpression during post-MI remodeling...
  40. ncbi request reprint Angiotensin II type 2 receptor-bradykinin B2 receptor functional heterodimerization
    Peter M Abadir
    Division of Endocrinology and Metabolism, Department of Medicine, University of Virginia, Charlottesville, VA, USA
    Hypertension 48:316-22. 2006
    ..Controlling the expression of AT2R-B2R, consequently influencing their biologically active dimerization, presents a potential therapeutic target for the treatment of hypertension and other cardiovascular and renal disorders...
  41. pmc Reinforcing feedback loop of renal cyclic guanosine 3' 5' -monophosphate and interstitial hydrostatic pressure in pressure-natriuresis
    DAVID C LIEB
    Division of Endocrinology and Metabolism, Department of Medicine, University of Virginia Health System, Charlottesville, VA, USA
    Hypertension 54:1278-83. 2009
    ..The results support an intrarenal positive-feedback loop wherein RI cGMP increases RIHP, which, in turn, increases RI cGMP, contributing to the reinforcement of pressure-natriuresis...
  42. ncbi request reprint Angiotensin type-2 receptors and cardiovascular function: are angiotensin type-2 receptors protective?
    Robert M Carey
    Division of Endocrinology and Metabolism, Department of Medicine, University of Virginia Health System, Charlottesville, VA 22908, USA
    Curr Opin Cardiol 20:264-9. 2005
    ....
  43. pmc G protein-coupled receptor kinase 4 gene variants in human essential hypertension
    Robin A Felder
    Department of Pathology, University of Virginia Health Sciences Center, Charlottesville, VA 22908, USA
    Proc Natl Acad Sci U S A 99:3872-7. 2002
    ..These findings provide a mechanism for the D(1) receptor coupling defect in the kidney and may explain the inability of the kidney to properly excrete sodium in genetic hypertension...
  44. pmc Inhibition of renal caveolin-1 reduces natriuresis and produces hypertension in sodium-loaded rats
    John J Gildea
    Department of Pathology, The Univ of Virginia, Charlottesville, VA 22908, USA
    Am J Physiol Renal Physiol 300:F914-20. 2011
    ..Furthermore, chronic disruption of lipid rafts or CAV1 protein expression in the kidney induces hypertension...
  45. ncbi request reprint Production and role of extracellular guanosine cyclic 3', 5' monophosphate in sodium uptake in human proximal tubule cells
    Shota Sasaki
    Department of Medicine, University of Virginia School of Medicine, Charlottesville, USA
    Hypertension 43:286-91. 2004
    ..The cGMP cellular export system is critical in the regulation of RPT cellular Na+ absorption in humans...
  46. ncbi request reprint Evidence for dysregulation of dimethylarginine dimethylaminohydrolase I in chronic hypoxia-induced pulmonary hypertension
    Lesley J Millatt
    Department of Anesthesiology, University of Virginia Health System, Charlottesville, USA
    Circulation 108:1493-8. 2003
    ..In addition, we determined whether dysregulation of the ADMA-metabolizing enzyme dimethylarginine dimethylaminohydrolase I (DDAH I) plays a role in this disease...
  47. ncbi request reprint Angiotensin II subtype 1 receptor blockade inhibits Clostridium difficile toxin A-induced intestinal secretion in a rabbit model
    Cirle S Alcantara
    Center for Global Health, Division of Infectious Disease and International Health, University of Virginia, Charlottesville, Virginia 22903, USA
    J Infect Dis 191:2090-6. 2005
    ..Our findings suggest that ANG II plays a significant role in the pathogenesis of C. difficile toxin-induced diarrhea...
  48. ncbi request reprint Interaction between AT1 and AT2 receptors during postinfarction left ventricular remodeling
    Szilard Voros
    Department of Medicine, University of Virginia Health System, Lee St, Box 800170, Charlottesville, Virginia 22908, USA
    Am J Physiol Heart Circ Physiol 290:H1004-10. 2006
    ..Pharmacological blockade of AT1-R is equivalent to AT2-R overexpression in attenuating post-MI remodeling. Genetic knockout of the AT1a-R is additive to AT2-R overexpression, due, at least in part, to blood pressure lowering...
  49. pmc TASK channel deletion in mice causes primary hyperaldosteronism
    Lucinda A Davies
    Department of Pharmacology, University of Virginia School of Medicine, Charlottesville, VA 22908, USA
    Proc Natl Acad Sci U S A 105:2203-8. 2008
    ..Our studies establish an animal model of nontumorigenic primary hyperaldosteronism and identify TASK channels as a possible therapeutic target for primary hyperaldosteronism...
  50. pmc Role of SRC family kinase in extracellular renal cyclic guanosine 3',5'-monophosphate- and pressure-induced natriuresis
    Nilberto R F Nascimento
    Division of Endocrinology and Metabolism, Department of Medicine, University of Virginia Health System, Charlottesville, VA 22908 1414, USA
    Hypertension 58:107-13. 2011
    ....
  51. pmc Molecular basis for the modulation of native T-type Ca2+ channels in vivo by Ca2+/calmodulin-dependent protein kinase II
    Junlan Yao
    Department of Pharmacology, University of Virginia School of Medicine, Charlottesville, Virginia 22908, USA
    J Clin Invest 116:2403-12. 2006
    ....
  52. ncbi request reprint Renal expression of angiotensin receptors in long-term diabetes and the effects of angiotensin type 1 receptor blockade
    Fabrice Bonnet
    Department of Medicine, University of Melbourne, Austin and Repatriation Medical Centre, Heidelberg West, Victoria 3081, Australia
    J Hypertens 20:1615-24. 2002
    ....
  53. ncbi request reprint Angiotensin type 2 receptor antagonism confers renal protection in a rat model of progressive renal injury
    Zemin Cao
    Department of Medicine, Austin and Repatriation Medical Centre Repatriation Campus, University of Melbourne, Heidelberg West, Victoria 3081, Australia
    J Am Soc Nephrol 13:1773-87. 2002
    ....
  54. doi request reprint Antihypertensive and renoprotective mechanisms of Renin inhibition in diabetic rats
    Robert M Carey
    Hypertension 52:63-4. 2008
  55. ncbi request reprint Angiotensin-II type 1 receptor-mediated hypertension in D4 dopamine receptor-deficient mice
    Martin J Bek
    Department of Pediatrics, Georgetown University Medical Center, Washington, DC 20057, USA
    Hypertension 47:288-95. 2006
    ..We conclude that the absence of the D(4) receptor increases blood pressure, possibly via increased angiotensin II type 1 receptor expression...
  56. ncbi request reprint Angiotensin receptors and aging
    Robert M Carey
    Hypertension 50:33-4. 2007
  57. ncbi request reprint Over-expression of angiotensin II type 2 receptor (agtr2) decreases collagen accumulation in atherosclerotic plaque
    Abhijit Dandapat
    Division of Cardiovascular Medicine, Gene Therapy Program, University of Arkansas for Medical Sciences, 4301 West Markham Street Slot 532, Little Rock, AR 72205, USA
    Biochem Biophys Res Commun 366:871-7. 2008
    ..This study demonstrates that AT2R over-expression reduces enhanced collagen accumulation, MMP expression and activity in atherosclerotic regions via inhibition of pro-oxidant signals...
  58. ncbi request reprint Angiotensin type-1 receptor blockade increases ACE 2 expression in the heart
    Robert M Carey
    Hypertension 43:943-4. 2004
  59. ncbi request reprint Role of Angiotensin-converting enzyme and neutral endopeptidase in flow-dependent remodeling
    Vyacheslav A Korshunov
    Center for Cardiovascular Research and Department of Medicine, University of Rochester, Rochester, NY 14642, USA
    J Vasc Res 41:148-56. 2004
    ..The results suggest that dual inhibition of NEP/ACE may have greater effects than ACE inhibition alone on vessel remodeling in hypertension...
  60. ncbi request reprint Over-expression of angiotensin II type 2 receptor (agtr2) reduces atherogenesis and modulates LOX-1, endothelial nitric oxide synthase and heme-oxygenase-1 expression
    Changping Hu
    Division of Cardiovascular Medicine, University of Arkansas for Medical Sciences and VA Medical Center, Little Rock, AR 72205, United States
    Atherosclerosis 199:288-94. 2008
    ..Thus, AT2R upregulation can reduce atherogenesis, possibly by modulating oxidative stress and the pro-inflammatory cascade, mediated via Akt-1. Over-expression of AT2R may be an important therapeutic approach in atherosclerosis...
  61. ncbi request reprint ACE inhibitors in patients with vascular disease: should the PEACE trial change medical practice?
    Robert M Carey
    Curr Hypertens Rep 7:119-20. 2005
  62. ncbi request reprint The renin-angiotensin-aldosterone system, glucose metabolism and diabetes
    Gilberta Giacchetti
    The Division of Endocrinology, Department of Internal Medicine, Universita Politecnica della Marche, 60020 Ancona, Italy
    Trends Endocrinol Metab 16:120-6. 2005
    ..An understanding of the tissue renin-angiotensin-aldosterone system, which is a crucial factor in the progression of tissue damage in DM, is imperative for protection against tissue damage in this chronic disease...
  63. ncbi request reprint Role of angiotensin type 2 receptors in vasodilation of resistance and capacitance vessels
    Robert M Carey
    Hypertension 48:824-5. 2006
  64. pmc Interstitial fibroblast-like cells express renin-angiotensin system components in a fibrosing murine kidney
    Hirokazu Okada
    Department of Nephrology, Saitama Medical College, Saitama, Japan
    Am J Pathol 160:765-72. 2002
    ..These data provide strong evidence for a tubulointerstitial RAS within the fibrosing kidney, and a linkage between the RAS and renal fibrogenesis...
  65. ncbi request reprint Patient information page from the Hormone Foundation. Hormones and hypertension
    Robert M Carey
    J Clin Endocrinol Metab 89:facing inside back cover. 2004

Research Grants18

  1. Renal AT2 Receptors in Hypertension
    ROBERT MUNSON CAREY; Fiscal Year: 2010
    ..This application will increase our understanding of the mechanisms whereby the kidney renin-angiotensin system regulates salt and water excretion, suggesting new molecular targets for the treatment and prevention of hypertension. ..
  2. PRESSURE NATRIURESIS MEDIATED BY EXTRACELLULAR cGMP
    Robert Carey; Fiscal Year: 2009
    ..Proof of the specific aims will identify and characterize a novel role of extracellular Rl cGMP and provide a potential therapeutic target for hypertension and other disease states associated with sodium retention. ..
  3. Natriuretic mechanisms of AT2 receptors
    Robert Carey; Fiscal Year: 2009
    ..This application will increase our understanding of the mechanisms whereby the kidney renin-angiotensin system regulates salt and water excretion, suggesting new molecular targets for the treatment and prevention of hypertension. ..
  4. RESEARCH TRAINING IN NEUROENDOCRINOLOGY
    Robert Carey; Fiscal Year: 2007
    ..candidates, and request four positions to maintain a critical mass of qualified trainees, and three summer fellowships for undergraduates to support a pipeline of trainees with high representation from underrepresented minorities ..
  5. PRESSURE NATRIURESIS MEDIATED BY EXTRACELLULAR cGMP
    Robert Carey; Fiscal Year: 2007
    ..Proof of the specific aims will identify and characterize a novel role of extracellular Rl cGMP and provide a potential therapeutic target for hypertension and other disease states associated with sodium retention. ..
  6. AT2 RECEPTORS IN BLOOD PRESSURE AND RENAL FUNCTION
    Robert Carey; Fiscal Year: 2004
    ..An understanding of the function of the AT2 receptor is necessary for an assessment of its potential role in the pathophysiology of hypertension and as a target for antihypertensive therapy. ..
  7. AT2 RECEPTOR MECHANISMS IN ANG II DEPENDENT HYPERTENSION
    Robert Carey; Fiscal Year: 2001
    ..The proposed studies will provide for the first time in any form of hypertension an understanding of the relevance and mediators of AT2 receptors in the long term control of blood pressure and kidney function. ..
  8. Natriuretic mechanisms of AT2 receptors
    ROBERT MUNSON CAREY; Fiscal Year: 2010
    ..This application will increase our understanding of the mechanisms whereby the kidney renin-angiotensin system regulates salt and water excretion, suggesting new molecular targets for the treatment and prevention of hypertension. ..