REGINA CARELLI

Summary

Affiliation: University of North Carolina
Country: USA

Publications

  1. ncbi request reprint Prefrontal cortical cell firing during maintenance, extinction, and reinstatement of goal-directed behavior for natural reward
    Yvette M Peters
    Department of Psychology, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Synapse 56:74-83. 2005
  2. ncbi request reprint When a good taste turns bad: Neural mechanisms underlying the emergence of negative affect and associated natural reward devaluation by cocaine
    Regina M Carelli
    Department of Psychology, The University of North Carolina, Chapel Hill, Chapel Hill, NC 27599, USA Neuroscience Center, The University of North Carolina, Chapel Hill, Chapel Hill, NC 27599, USA Electronic address
    Neuropharmacology 76:360-9. 2014
  3. ncbi request reprint Functional microcircuitry in the accumbens underlying drug addiction: insights from real-time signaling during behavior
    Regina M Carelli
    Department of Psychology, CB 3270, Davie Hall, University of North Carolina, Chapel Hill, North Carolina 27599 3270 USA
    Curr Opin Neurobiol 14:763-8. 2004
  4. ncbi request reprint Nucleus accumbens cell firing and rapid dopamine signaling during goal-directed behaviors in rats
    Regina M Carelli
    Department of Psychology, The University of North Carolina at Chapel Hill, CB 3270, Davie Hall, Chapel Hill, NC 27599 3270, USA
    Neuropharmacology 47:180-9. 2004
  5. ncbi request reprint Anatomic distribution of reinforcer selective cell firing in the core and shell of the nucleus accumbens
    Regina M Carelli
    Department of Psychology, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 3270, USA
    Synapse 59:69-73. 2006
  6. ncbi request reprint Basolateral amygdala neurons encode cocaine self-administration and cocaine-associated cues
    Regina M Carelli
    Department of Psychology, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 3270, USA
    J Neurosci 23:8204-11. 2003
  7. ncbi request reprint Activation of accumbens cell firing by stimuli associated with cocaine delivery during self-administration
    R M Carelli
    Department of Psychology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 3270, USA
    Synapse 35:238-42. 2000
  8. ncbi request reprint Nucleus accumbens cell firing during goal-directed behaviors for cocaine vs. 'natural' reinforcement
    Regina M Carelli
    Department of Psychology, The University of North Carolina at Chapel Hill, CB 3270, Davie Hall, Chapel Hill, NC 27599 3270, USA
    Physiol Behav 76:379-87. 2002
  9. ncbi request reprint Examination of factors mediating the transition to behaviorally correlated nucleus accumbens cell firing during cocaine self-administration sessions in rats
    R M Carelli
    Department of Psychology, The University of North Carolina at Chapel Hill, 27599 3270, USA
    Behav Brain Res 104:127-39. 1999
  10. ncbi request reprint Selective encoding of cocaine versus natural rewards by nucleus accumbens neurons is not related to chronic drug exposure
    Regina M Carelli
    Department of Psychology, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 3270, USA
    J Neurosci 23:11214-23. 2003

Collaborators

Detail Information

Publications50

  1. ncbi request reprint Prefrontal cortical cell firing during maintenance, extinction, and reinstatement of goal-directed behavior for natural reward
    Yvette M Peters
    Department of Psychology, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Synapse 56:74-83. 2005
    ....
  2. ncbi request reprint When a good taste turns bad: Neural mechanisms underlying the emergence of negative affect and associated natural reward devaluation by cocaine
    Regina M Carelli
    Department of Psychology, The University of North Carolina, Chapel Hill, Chapel Hill, NC 27599, USA Neuroscience Center, The University of North Carolina, Chapel Hill, Chapel Hill, NC 27599, USA Electronic address
    Neuropharmacology 76:360-9. 2014
    ..This article is part of a Special Issue entitled 'NIDA 40th Anniversary Issue'...
  3. ncbi request reprint Functional microcircuitry in the accumbens underlying drug addiction: insights from real-time signaling during behavior
    Regina M Carelli
    Department of Psychology, CB 3270, Davie Hall, University of North Carolina, Chapel Hill, North Carolina 27599 3270 USA
    Curr Opin Neurobiol 14:763-8. 2004
    ..These findings are considered with respect to the functional microcircuitry in the nucleus accumbens that underlies goal-directed behavior and the role of this circuit in drug addiction...
  4. ncbi request reprint Nucleus accumbens cell firing and rapid dopamine signaling during goal-directed behaviors in rats
    Regina M Carelli
    Department of Psychology, The University of North Carolina at Chapel Hill, CB 3270, Davie Hall, Chapel Hill, NC 27599 3270, USA
    Neuropharmacology 47:180-9. 2004
    ....
  5. ncbi request reprint Anatomic distribution of reinforcer selective cell firing in the core and shell of the nucleus accumbens
    Regina M Carelli
    Department of Psychology, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 3270, USA
    Synapse 59:69-73. 2006
    ..These findings are discussed with respect to the functional organization of the NAc...
  6. ncbi request reprint Basolateral amygdala neurons encode cocaine self-administration and cocaine-associated cues
    Regina M Carelli
    Department of Psychology, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 3270, USA
    J Neurosci 23:8204-11. 2003
    ..These findings are discussed with respect to the role of the BLA in cocaine addiction as well as previous studies characterizing Acb cell firing during cocaine self-administration...
  7. ncbi request reprint Activation of accumbens cell firing by stimuli associated with cocaine delivery during self-administration
    R M Carelli
    Department of Psychology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 3270, USA
    Synapse 35:238-42. 2000
    ..These findings are discussed with respect to the role of the Acb in mediating conditioned responses associated with drug reinforcement...
  8. ncbi request reprint Nucleus accumbens cell firing during goal-directed behaviors for cocaine vs. 'natural' reinforcement
    Regina M Carelli
    Department of Psychology, The University of North Carolina at Chapel Hill, CB 3270, Davie Hall, Chapel Hill, NC 27599 3270, USA
    Physiol Behav 76:379-87. 2002
    ..abused substances...
  9. ncbi request reprint Examination of factors mediating the transition to behaviorally correlated nucleus accumbens cell firing during cocaine self-administration sessions in rats
    R M Carelli
    Department of Psychology, The University of North Carolina at Chapel Hill, 27599 3270, USA
    Behav Brain Res 104:127-39. 1999
    ..These findings support the notion that cocaine self-administration sessions in rats consists of two distinct behavioral phases that are mediated by different neurophysiological mechanisms operating in the NA...
  10. ncbi request reprint Selective encoding of cocaine versus natural rewards by nucleus accumbens neurons is not related to chronic drug exposure
    Regina M Carelli
    Department of Psychology, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 3270, USA
    J Neurosci 23:11214-23. 2003
    ..These findings support the view that separate neural circuits in the Acb differentially encode information about cocaine versus natural reward, and that this functional organization is not a direct consequence of chronic drug exposure...
  11. ncbi request reprint Evidence that separate neural circuits in the nucleus accumbens encode cocaine versus "natural" (water and food) reward
    R M Carelli
    Department of Psychology, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 3270, USA
    J Neurosci 20:4255-66. 2000
    ..These findings indicate that in the well-trained animal, cocaine activates a neural circuit in the Acb that is largely separate from the circuit that processes information about food and water reward...
  12. ncbi request reprint Nucleus accumbens cell firing during maintenance, extinction, and reinstatement of cocaine self-administration behavior in rats
    R M Carelli
    Department of Psychology, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 3270, USA
    Brain Res 866:44-54. 2000
    ..These findings support the notion that specific factors operating within the self-administration context differentially control pre- versus post-response discharge patterns of Acb neurons...
  13. ncbi request reprint Selective activation of accumbens neurons by cocaine-associated stimuli during a water/cocaine multiple schedule
    R M Carelli
    Department of Psychology, The University of North Carolina at Chapel Hill, CB 3270, Davie Hall, Chapel Hill, NC 27599 3270, USA
    Brain Res 907:156-61. 2001
    ..This finding indicates that the responsiveness of cocaine selective neurons to cocaine-associated stimuli likely represents a conditioned response as opposed to a generalized stimulus-evoked discharge...
  14. ncbi request reprint Dopamine operates as a subsecond modulator of food seeking
    Mitchell F Roitman
    Department of Psychology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 3270, USA
    J Neurosci 24:1265-71. 2004
    ..Rather, dopamine returned to baseline levels. Together, the results strongly implicate subsecond dopamine signaling in the nucleus accumbens as a real-time modulator of food-seeking behavior...
  15. pmc Neural encoding of cocaine-seeking behavior is coincident with phasic dopamine release in the accumbens core and shell
    Catarina A Owesson-White
    Department of Psychology, The University of North Carolina, Chapel Hill, NC 27599, USA
    Eur J Neurosci 30:1117-27. 2009
    ....
  16. ncbi request reprint Extinction of cocaine self-administration reveals functionally and temporally distinct dopaminergic signals in the nucleus accumbens
    Garret D Stuber
    Curriculum in Neurobiology, The University of North Carolina, Chapel Hill, North Carolina 27599, USA
    Neuron 46:661-9. 2005
    ....
  17. ncbi request reprint The nucleus accumbens and reward: neurophysiological investigations in behaving animals
    Regina M Carelli
    University of North Carolina at Chapel Hill, USA
    Behav Cogn Neurosci Rev 1:281-96. 2002
    ....
  18. pmc Regional specificity in the real-time development of phasic dopamine transmission patterns during acquisition of a cue-cocaine association in rats
    Brandon J Aragona
    Department of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 3290, USA
    Eur J Neurosci 30:1889-99. 2009
    ....
  19. ncbi request reprint Abstinence from cocaine self-administration heightens neural encoding of goal-directed behaviors in the accumbens
    Jonathan A Hollander
    Department of Psychology, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 3270, USA
    Neuropsychopharmacology 30:1464-74. 2005
    ....
  20. ncbi request reprint Rapid dopamine signaling in the nucleus accumbens during contingent and noncontingent cocaine administration
    Garret D Stuber
    Curriculum in Neurobiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Neuropsychopharmacology 30:853-63. 2005
    ....
  21. pmc Preferential enhancement of dopamine transmission within the nucleus accumbens shell by cocaine is attributable to a direct increase in phasic dopamine release events
    Brandon J Aragona
    Department of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 3290, USA
    J Neurosci 28:8821-31. 2008
    ..Together, these results demonstrate that cocaine administration results in a temporally and regionally specific increase in phasic dopamine release that is significantly regulated by dopamine autoreceptors...
  22. ncbi request reprint Coordinated accumbal dopamine release and neural activity drive goal-directed behavior
    Joseph F Cheer
    Department of Chemistry and Neuroscience Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 3290, USA
    Neuron 54:237-44. 2007
    ..This work establishes a temporal link between anticipatory rises of dopamine and firing patterns in the NAc shell during ICSS and suggests that they may play a similar role with natural rewards and during drug self-administration...
  23. ncbi request reprint Cocaine-associated stimuli increase cocaine seeking and activate accumbens core neurons after abstinence
    Jonathan A Hollander
    Department of Psychology, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 3270, USA
    J Neurosci 27:3535-9. 2007
    ....
  24. ncbi request reprint Accumbens activity during a multiple schedule for water and sucrose reinforcement in rats
    Richard G Roop
    Department of Psychology, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 3270, USA
    Synapse 43:223-6. 2002
    ..These findings are discussed with respect to how Acb neurons encode goal-directed behaviors for "natural" reinforcers including food, water, and a palatable sweet solution...
  25. ncbi request reprint Nucleus accumbens neurons are innately tuned for rewarding and aversive taste stimuli, encode their predictors, and are linked to motor output
    Mitchell F Roitman
    Department of Psychology, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    Neuron 45:587-97. 2005
    ..Thus, NAc neurons are innately tuned to rewarding and aversive stimuli and rapidly develop responses to predictive cues. The results indicate that the output of the NAc is very different when rats taste rewarding versus aversive stimuli...
  26. ncbi request reprint Behavioral responding and nucleus accumbens cell firing are unaltered following periods of abstinence from sucrose
    JOSHUA L JONES
    Department of Psychology, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 3270, USA
    Synapse 62:219-28. 2008
    ..These findings are discussed with respect to the role of the NAc in processing goal-directed behaviors for drug vs. natural rewards following periods of abstinence...
  27. ncbi request reprint Real-time measurements of phasic changes in extracellular dopamine concentration in freely moving rats by fast-scan cyclic voltammetry
    Paul E M Phillips
    Department of Chemistry, University of North Carolina at Chapel Hill, NC, USA
    Methods Mol Med 79:443-64. 2003
  28. ncbi request reprint An examination of nucleus accumbens cell firing during extinction and reinstatement of water reinforcement behavior in rats
    Jonathan A Hollander
    Department of Psychology, The University of North Carolina at Chapel Hill, CB 3270, Davie Hall, Chapel Hill, NC 27599 3270, USA
    Brain Res 929:226-35. 2002
    ..These findings are discussed in terms of how Acb neurons process information related to 'natural' reinforcers versus drugs of abuse...
  29. ncbi request reprint Nucleus accumbens neurons encode Pavlovian approach behaviors: evidence from an autoshaping paradigm
    Jeremy J Day
    Department of Psychology, The University of North Carolina at Chapel Hill, 27599 3270, USA
    Eur J Neurosci 23:1341-51. 2006
    ..The magnitude and prevalence of cue-related neural responses reported here indicates that the NAc encodes biologically significant, repetitive approach responses that may model the compulsive nature of drug addiction in humans...
  30. pmc The nucleus accumbens and Pavlovian reward learning
    Jeremy J Day
    Department of Psychology University of North Carolina at Chapel Hill, Davie Hall, Chapel Hill, NC 27599 3270, USA
    Neuroscientist 13:148-59. 2007
    ....
  31. pmc Basolateral amygdala modulates terminal dopamine release in the nucleus accumbens and conditioned responding
    JOSHUA L JONES
    Department of Psychology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    Biol Psychiatry 67:737-44. 2010
    ..However, the role of associative neural substrates such as the basolateral amygdala (BLA) in regulating phasic dopamine release in the NAc, particularly during reward seeking, remains unknown...
  32. ncbi request reprint Self-administration of heroin produces alterations in the expression of inducible nitric oxide synthase
    Ryan K Lanier
    Department of Psychology, Program in Biological Psychology, Davie Hall CB 3270, Chapel Hill, NC 27599 3270, USA
    Drug Alcohol Depend 66:225-33. 2002
    ....
  33. pmc Real-time chemical responses in the nucleus accumbens differentiate rewarding and aversive stimuli
    Mitchell F Roitman
    Department of Psychology, University of Illinois, Chicago, Illinois 60607, USA
    Nat Neurosci 11:1376-7. 2008
    ..This rapid encoding may serve to guide ongoing behavioral responses and promote plastic changes in underlying circuitry...
  34. ncbi request reprint Dopamine release is heterogeneous within microenvironments of the rat nucleus accumbens
    R Mark Wightman
    Department of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 3290, USA
    Eur J Neurosci 26:2046-54. 2007
    ..These findings reveal an unanticipated spatial and temporal heterogeneity of dopamine transmission within the NAc that may depend upon the firing of specific subpopulations of dopamine neurons...
  35. ncbi request reprint Subsecond dopamine release promotes cocaine seeking
    Paul E M Phillips
    Department of Psychology, Neuroscience Center, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    Nature 422:614-8. 2003
    ..These findings reveal an unprecedented role for dopamine in the regulation of drug taking in real time...
  36. pmc Distinct subsets of nucleus accumbens neurons encode operant responding for ethanol versus water
    Donita L Robinson
    Bowles Center for Alcohol Studies, University of North Carolina, Chapel Hill, NC 27599 7178, USA
    Eur J Neurosci 28:1887-94. 2008
    ..water reinforcement in well-trained rats, and that reinforcer preference and spatial cues are important components of this differential information processing...
  37. ncbi request reprint Associative learning mediates dynamic shifts in dopamine signaling in the nucleus accumbens
    Jeremy J Day
    Department of Psychology, Davie Hall CB no 3270, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    Nat Neurosci 10:1020-8. 2007
    ..Consistent with proposed roles in reward prediction and incentive salience, these results indicate that rapid dopamine release provides a reward signal that is dynamically modified by associative learning...
  38. pmc Dissecting motivational circuitry to understand substance abuse
    Robert A Wheeler
    Department of Psychology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Neuropharmacology 56:149-59. 2009
    ..Collectively, these findings provide critical insight into the functional organization of the NAc that can be used to guide additional studies aimed at dissecting the neural code underlying compulsive drug-seeking behavior...
  39. ncbi request reprint Continuous exposure to the competitive N-methyl-D: -aspartate receptor antagonist, LY235959, facilitates escalation of cocaine consumption in Sprague-Dawley rats
    Richard M Allen
    Department of Psychology, University of Colorado at Denver and Health Sciences Center, Downtown Denver Campus, CB 173, P O Box 173364, Denver, CO 80217, USA
    Psychopharmacology (Berl) 191:341-51. 2007
    ..Nevertheless, the precise mechanisms that mediate increases in cocaine consumption in a drug-using individual are not fully understood...
  40. doi request reprint Behavioral and electrophysiological indices of negative affect predict cocaine self-administration
    Robert A Wheeler
    Department of Psychology, University of North Carolina, Chapel Hill, NC 27599, USA
    Neuron 57:774-85. 2008
    ..The dynamic nature of this conditioned switch in affect and the neural code reveals a mechanism by which cues may exert control over drug self-administration...
  41. pmc Phasic nucleus accumbens dopamine release encodes effort- and delay-related costs
    Jeremy J Day
    Department of Psychology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    Biol Psychiatry 68:306-9. 2010
    ..Dopamine transmission within the nucleus accumbens (NAc) has been heavily implicated in reward-learning and decision-making, but it is unclear how dopamine release might contribute to decisions that involve costs...
  42. pmc Simultaneous dopamine and single-unit recordings reveal accumbens GABAergic responses: implications for intracranial self-stimulation
    Joseph F Cheer
    Department of Chemistry and Neuroscience Center, University of North Carolina, Chapel Hill, NC 27599, USA
    Proc Natl Acad Sci U S A 102:19150-5. 2005
    ..Thus, neurons in the NAc are preferentially inhibited by GABA(A) receptors after MFB stimulation, a mechanism that may also be important in ICS...
  43. pmc Synaptic overflow of dopamine in the nucleus accumbens arises from neuronal activity in the ventral tegmental area
    Leslie A Sombers
    Department of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 3290, USA
    J Neurosci 29:1735-42. 2009
    ..The results from these three distinct experiments directly demonstrate, for the first time, how neuronal firing of dopamine neurons originating in the VTA translates into synaptic overflow in a key terminal region, the NAc shell...
  44. pmc Dynamic changes in accumbens dopamine correlate with learning during intracranial self-stimulation
    Catarina A Owesson-White
    Department of Psychology, University of North Carolina, Chapel Hill, NC 27599 3290, USA
    Proc Natl Acad Sci U S A 105:11957-62. 2008
    ..The results show the dynamic nature of chemical signaling in the NAc during ICSS and provide new insight into the role of NAc dopamine in reward-related behaviors...
  45. ncbi request reprint Effects of the competitive N-methyl-D-aspartate receptor antagonist, LY235959 [(-)-6-phosphonomethyl-deca-hydroisoquinoline-3-carboxylic acid], on responding for cocaine under both fixed and progressive ratio schedules of reinforcement
    Richard M Allen
    Department of Psychology, University of Colorado at Denver and Health Sciences Center, CB No 173, P O Box 173364, Denver, CO 80217, USA
    J Pharmacol Exp Ther 315:449-57. 2005
    ..These data suggest that LY235959 decreased the reinforcing effectiveness of cocaine, a finding reported with systemically administered NMDA receptor antagonists other than dizocilpine...
  46. pmc Electroosmotic flow and its contribution to iontophoretic delivery
    Natalie R Herr
    Department of Chemistry and Neuroscience Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 3290, USA
    Anal Chem 80:8635-41. 2008
    ..With this information, quantitative iontophoresis is possible for electrochemically inactive drugs by using NPE as a marker for EOF...
  47. doi request reprint Methamphetamine induces chronic corticostriatal depression: too much of a bad thing
    Jeremy J Day
    Department of Psychology, University of North Carolina at Chapel Hill, CB 3270, Davie Hall, Chapel Hill, NC 27599 3270, USA
    Neuron 58:6-7. 2008
    ..In this issue of Neuron, Bamford and colleagues describe a novel neurobiological substrate that may contribute to this effect...
  48. pmc Rank estimation and the multivariate analysis of in vivo fast-scan cyclic voltammetric data
    Richard B Keithley
    Department of Chemistry, Neuroscience Center and Neurobiology Curriculum, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    Anal Chem 82:5541-51. 2010
    ..In addition, pH change was the majority noise carrier of in vivo training sets while dopamine prediction was more sensitive to noise...
  49. pmc Cocaine but not natural reward self-administration nor passive cocaine infusion produces persistent LTP in the VTA
    Billy T Chen
    Ernest Gallo Clinic and Research Center, Department of Neurology, University of California, San Francisco, Emeryville, CA 94608, USA
    Neuron 59:288-97. 2008
    ..Such persistent synaptic potentiation in VTA DA neurons may represent a fundamental cellular phenomenon driving pathological drug-seeking behavior...
  50. ncbi request reprint The neuroscience of pleasure. Focus on "Ventral pallidum firing codes hedonic reward: when a bad taste turns good"
    Robert A Wheeler
    J Neurophysiol 96:2175-6. 2006

Research Grants19

  1. Combined Voltammetry/Electrophysiology in Behaving Rats
    REGINA CARELLI; Fiscal Year: 2007
    ..This study will provide evidence that changes in Acb firing patterns are the result of phasic DA and determine the involvement of specific DA receptors in this process. ..
  2. Neurophysiological Study: Cocaine and Natural Reinforcers
    Regina M Carelli; Fiscal Year: 2010
    ..1992;Childress et al., 1999). ..
  3. Neurophysiological Study: Cocaine & Natural Reinforcers
    REGINA CARELLI; Fiscal Year: 2001
    ..1992; Childress et al., 1999). Collectively, these studies will provide important insight into the functional organization of the Acb and its role in reinforcement-related processing in behaving animals. ..
  4. Combined Voltammetry/Electrophysiology in Behaving Rats
    REGINA CARELLI; Fiscal Year: 2009
    ..The information obtained from the present application will provide insight into the neurobiological mechanisms mediating cocaine addiction and thereby aid in the development of pharmacological agents to treat human drug addiction. ..
  5. Neurophysiological Study: Cocaine and Natural Reinforcers
    REGINA CARELLI; Fiscal Year: 2009
    ..1992; Childress et al., 1999). ..
  6. Combined Voltammetry/Electrophysiology in Behaving Rats
    REGINA CARELLI; Fiscal Year: 2007
    ..This study will provide evidence that changes in Acb firing patterns are the result of phasic DA and determine the involvement of specific DA receptors in this process. ..
  7. Neurophysiological Study: Cocaine and Natural Reinforcers
    REGINA CARELLI; Fiscal Year: 2007
    ..1992; Childress et al., 1999). ..
  8. Combined Voltammetry/Electrophysiology in Behaving Rats
    REGINA CARELLI; Fiscal Year: 2006
    ..This study will provide evidence that changes in Acb firing patterns are the result of phasic DA and determine the involvement of specific DA receptors in this process. ..
  9. Neurophysiological Study: Cocaine & Natural Reinforcers
    REGINA CARELLI; Fiscal Year: 2006
    ..1992; Childress et al., 1999). Collectively, these studies will provide important insight into the functional organization of the Acb and its role in reinforcement-related processing in behaving animals. ..
  10. Combined Voltammetry/Electrophysiology in Behaving Rats
    REGINA CARELLI; Fiscal Year: 2005
    ..This study will provide evidence that changes in Acb firing patterns are the result of phasic DA and determine the involvement of specific DA receptors in this process. ..
  11. Neurophysiological Study: Cocaine & Natural Reinforcers
    REGINA CARELLI; Fiscal Year: 2005
    ..1992; Childress et al., 1999). Collectively, these studies will provide important insight into the functional organization of the Acb and its role in reinforcement-related processing in behaving animals. ..
  12. Combined Voltammetry/Electrophysiology in Behaving Rats
    REGINA CARELLI; Fiscal Year: 2004
    ..This study will provide evidence that changes in Acb firing patterns are the result of phasic DA and determine the involvement of specific DA receptors in this process. ..
  13. Neurophysiological Study: Cocaine & Natural Reinforcers
    REGINA CARELLI; Fiscal Year: 2004
    ..1992; Childress et al., 1999). Collectively, these studies will provide important insight into the functional organization of the Acb and its role in reinforcement-related processing in behaving animals. ..
  14. Neurophysiological Study: Cocaine & Natural Reinforcers
    REGINA CARELLI; Fiscal Year: 2003
    ..1992; Childress et al., 1999). Collectively, these studies will provide important insight into the functional organization of the Acb and its role in reinforcement-related processing in behaving animals. ..
  15. Combined Voltammetry/Electrophysiology in Behaving Rats
    REGINA CARELLI; Fiscal Year: 2002
    ..As such, we will be able to directly examine the contribution of DA in mediating underlying cellular mechanisms in the Acb that are involved in encoding information related to cocaine reinforcement. ..
  16. Neurophysiological Study: Cocaine & Natural Reinforcers
    REGINA CARELLI; Fiscal Year: 2002
    ..1992; Childress et al., 1999). Collectively, these studies will provide important insight into the functional organization of the Acb and its role in reinforcement-related processing in behaving animals. ..
  17. Combined Voltammetry/Electrophysiology in Behaving Rats
    Regina M Carelli; Fiscal Year: 2010
    ..The information obtained from the present application will provide insight into the neurobiological mechanisms mediating cocaine addiction and thereby aid in the development of pharmacological agents to treat human drug addiction. ..