Robert Darrell Cardiff
Affiliation: University of California
- Three interrelated themes in current breast cancer research: gene addiction, phenotypic plasticity, and cancer stem cellsRobert D Cardiff
Department of Pathology, Center for Comparative Medicine, University of California, Davis, County Road 98 and Hutchison Drive, Davis, CA 95616, USA
Breast Cancer Res 13:216. 2011..These themes cooperate in breast cancer, as induction of epithelial-to-mesenchymal transition enhances self-renewal and expression of cancer stem cells, which are believed to facilitate tumor resistance...
- The membrane mucin MUC4 is elevated in breast tumor lymph node metastases relative to matched primary tumors and confers aggressive properties to breast cancer cellsHeather C Workman
Division of Basic Sciences, UC Davis Cancer Center, 4645 2ndAvenue, Sacramento, California 95817, USA
Breast Cancer Res 11:R70. 2009....
- Selective estrogen receptor modulators inhibit growth and progression of premalignant lesions in a mouse model of ductal carcinoma in situRuria Namba
Department of Pathology and Laboratory Medicine, School of Medicine, University of California, Davis, Sacramento, CA, USA
Breast Cancer Res 7:R881-9. 2005..We studied the ovarian-hormone-responsiveness of one of the lines with a particular focus on the effects of two related SERMs, tamoxifen and ospemifene...
- Mammary carcinoma behavior is programmed in the precancer stem cellPatrizia Damonte
Department of Pathology and Laboratory Medicine, Center for Comparative Medicine, UC Davis, County Road 98 and Hutchison Drive, Davis, California 95616, USA
Breast Cancer Res 10:R50. 2008..Transition to carcinoma has a consistent latency for each line, and three of the lines also exhibit pulmonary metastatic potential...
- Heterogeneity of mammary lesions represent molecular differencesRuria Namba
Department of Pathology and Laboratory Medicine, School of Medicine, University of California at Davis, Sacramento, CA 95817, USA
BMC Cancer 6:275. 2006..Each MIN-O line has distinguishable morphologies, metastatic potentials and estrogen dependencies...
- The comparative pathology of human and mouse mammary glandsR D Cardiff
Department of Pathology and The Center for Comparative Medicine, University of California, Davis 95616, USA
J Mammary Gland Biol Neoplasia 4:105-22. 1999..In this essay we review our experience with the histopathology of human and mouse mammary disease by comparing the normal gland with hyperplastic, dysplastic and neoplastic lesions of traditional and transgenic origin...
- Histopathology as a predictive biomarker: strengths and limitationsRobert D Cardiff
Department of Medical Pathology and Laboratory Medicine, University of California, Davis CA 95616, USA
J Nutr 136:2673S-5S. 2006
- Validation: the new challenge for pathologyRobert D Cardiff
Center for Comparative Medicine, University of California, Davis, Davis, California 95616, USA
Toxicol Pathol 32:31-9. 2004..The phenotypes can be placed into structural and functional clusters with shared characteristics leading to the concepts of Pathway Pathology: tumor phenotype reflects the genotype...
- Genetically engineered mouse models of mammary intraepithelial neoplasiaR D Cardiff
Department of Pathology and Center for Comparative Medicine, University of California, Davis 95616, USA
J Mammary Gland Biol Neoplasia 5:421-37. 2000..Here, we review the literature characterizing early lesions of GEM models of mammary cancer, discuss the principles of the Focality, Atypia, and Association and present an introduction of mammary transplantation for model Validation...
- Epithelial to Mesenchymal Transition Tumors: Fallacious or Snail's Pace?Robert D Cardiff
Center for Comparative Medicine, Department of Pathology and Laboratory Medicine, University of California, Davis School of Medicine, Davis, California 95616, USA
Clin Cancer Res 11:8534-7. 2005
- Morphologic manifestations of gene-specific molecular alterations ("genetic addictions") in mouse models of diseaseS S Couto
University of California Davis, Center for Comparative Medicine, Davis, CA, USA
Vet Pathol 49:116-29. 2012....
- Validity of mouse mammary tumour models for human breast cancer: comparative pathologyR D Cardiff
Department of Pathology and University of California Davis Center for Comparative Medicine, County Road 98 and Hutchison Drive, UC Davis, Davis, CA 95616, USA
Microsc Res Tech 52:224-30. 2001..2000). This review emphasizes the proposed nomenclature and the differences between the models and human breast cancer with the intention of stimulating discussion and the development of new models...
- 'One medicine---one pathology': are veterinary and human pathology prepared?Robert D Cardiff
Center for Comparative Medicine, University of California, Davis, CA 95616, USA
Lab Invest 88:18-26. 2008..The impending glut of new genetically engineered mice creates an urgent need for prepared investigators and pathologists...
- The biology of mammary transgenes: five rulesR D Cardiff
Department of Pathology, School of Medicine, University of California at Davis 95616, USA
J Mammary Gland Biol Neoplasia 1:61-73. 1996..The study of the comparative pathology of mammary tumorigenesis in many strains of transgenic mice provides examples of these principles...
- Mammary cancer in humans and mice: a tutorial for comparative pathology. The CD-ROMR D Cardiff
Department of Pathology and Center for Comparative Medicine, University of California, Davis 95616, USA
J Mammary Gland Biol Neoplasia 5:243-4. 2000..Every genetically engineered model has one or more accompanying citations. Tables are provided for orientation and organization. The CD includes zoom capabilities, a search engine, and a help mode...
- Epilog: comparative medicine, one medicine and genomic pathologyRobert D Cardiff
Department of Pathology and Laboratory Medicine, Center for Comparative Medicine, University of California, Davis, CA 95616, USA
Breast Dis 28:107-10. 2007..This issue examines these contributions and opens the way for the examination of other mammalian species. The development of a new discipline, Genomic Pathology, can now be anticipated...
- The pathology of EMT in mouse mammary tumorigenesisRobert Darrell Cardiff
Center for Comparative Medicine, University of California, Davis, One Shields Ave, Davis, CA 95616, USA
J Mammary Gland Biol Neoplasia 15:225-33. 2010..This review provides a historical perspective leading to the current status in the context of some of the key molecular biology. The biology of mouse mammary EMT tumorigenesis is discussed with comparisons to human breast cancer...
- Polyomavirus middle T-induced mammary intraepithelial neoplasia outgrowths: single origin, divergent evolution, and multiple outcomesJeannie E Maglione
Department of Medicine, UCSD Cancer Center, School of Medicine, University of California-San Diego, La Jolla, CA, USA
Mol Cancer Ther 3:941-53. 2004..These lines provide an opportunity to study the full range of events occurring secondary to PyV-mT expression in the mammary gland...
- Preclinical imaging of mammary intraepithelial neoplasia with positron emission tomographyCraig K Abbey
Department of Biomedical Engineering, University of California, Davis, CA 95616, USA
J Mammary Gland Biol Neoplasia 11:137-49. 2006..We conclude with a brief survey of emerging approaches in small-animal PET imaging...
- Molecular characterization of the transition to malignancy in a genetically engineered mouse-based model of ductal carcinoma in situRuria Namba
Department of Pathology and Laboratory Medicine, School of Medicine, University of California-Davis, Sacramento, California 95817, USA
Mol Cancer Res 2:453-63. 2004..With consistent tumor latency and molecular profiles, this model provides an experimental platform that can be used to assess functional genomics and molecular pharmacology and to test promising chemoprevention strategies...
- EMT tumorigenesis in the mouse mammary glandPatrizia Damonte
Center for Comparative Medicine, University of California at Davis, Davis, CA 95616, USA
Lab Invest 87:1218-26. 2007..This suggests that potential EMT tumors are best designated EMT-phenotype tumors...
- Somatic mutation of p53 leads to estrogen receptor alpha-positive and -negative mouse mammary tumors with high frequency of metastasisSuh Chin J Lin
Departments of Developmental and Cell Biology, University of California, Irvine, California 92697, USA
Cancer Res 64:3525-32. 2004..Thus, this tumor system reproduces many important features of human breast cancer and provides tools for the study of the origins of ERalpha-positive and -negative breast tumors in mice...
- In vivo positron-emission tomography imaging of progression and transformation in a mouse model of mammary neoplasiaCraig K Abbey
Department of Biomedical Engineering, University of California, One Shields Avenue, Davis, CA 95616, USA
Proc Natl Acad Sci U S A 101:11438-43. 2004..Furthermore, quantitative markers of disease extracted from the images can be used to track proliferation and progression in vivo over multiple time points...
- Syngeneic mouse mammary carcinoma cell lines: two closely related cell lines with divergent metastatic behaviorAlexander D Borowsky
Department of Medical Pathology and Laboratory Medicine, UC Davis School of Medicine, Sacramento, CA 95817, USA
Clin Exp Metastasis 22:47-59. 2005..Therefore, these two cell lines provide a stable, reproducible resource for the study of metastasis modulators, AKT molecular pathway interactions, and gene target and marker discovery...
- Rapamycin inhibits growth of premalignant and malignant mammary lesions in a mouse model of ductal carcinoma in situRuria Namba
Department of Pathology and Laboratory Medicine, School of Medicine, University of California, Davis, Sacramento, CA 95817, USA
Clin Cancer Res 12:2613-21. 2006..Although the inhibitory effect of rapamycin was striking, rapamycin treatment did not completely obliterate the lesions...
- Inflammation and atrophy precede prostatic neoplasia in a PhIP-induced rat modelAlexander D Borowsky
University of California and the Lawrence Livermore NationalLaboratory, USA
Neoplasia 8:708-15. 2006..Overall, these findings suggest that the pathogenesis of prostatic neoplasia in the PhIP-treated rat prostate proceeds from inflammation to postinflammatory proliferative atrophy to PIN...
- Precancer in mice: animal models used to understand, prevent, and treat human precancersRobert D Cardiff
The UCD Center for Comparative Medicine, University of California, Davis, Davis, California 95616, USA
Toxicol Pathol 34:699-707. 2006..These studies suggest that genetically engineered mice are very useful preclinical models for chemoprevention and therapy...
- Molecular analysis of metastasis in a polyomavirus middle T mouse model: the role of osteopontinKatayoun Alavi Jessen
Department of Pathology, University of California, Davis, School of Medicine, Sacramento, California, USA
Breast Cancer Res 6:R157-69. 2004..In order to study metastatic disease, we employed the use of two related polyomavirus middle T transgenic mouse tumor transplant models of mammary carcinoma (termed Met and Db) that display significant differences in metastatic potential...
- Pathway pathology: histological differences between ErbB/Ras and Wnt pathway transgenic mammary tumorsAndrea Rosner
Center for Comparative Medicine, University of California, Davis 95616, USA
Am J Pathol 161:1087-97. 2002....
- Fibroblast growth factor 8 isoform B overexpression in prostate epithelium: a new mouse model for prostatic intraepithelial neoplasiaZhigang Song
Department of Pathology, University of Southern California, Keck School of Medicine, Los Angeles, California 90033, USA
Cancer Res 62:5096-105. 2002..These transgenic mice represent a "natural" animal model for investigating the mechanism of development and progression of prostatic diseases, such as prostatic hyperplasia and preneoplastic lesions...
- Mammary tumor latency is increased in mice lacking the inducible nitric oxide synthaseLesley G Ellies
Department of Medicine, School of Medicine, University of California at San Diego, La Jolla, CA 92093, USA
Int J Cancer 106:1-7. 2003..These results indicate a role for iNOS in tumorigenesis, particularly in the regulation of early events...
- Prostatic intraepithelial neoplasia in genetically engineered miceJae-Hak Park
Center for Comparative Medicine and Department of Medical Pathology, University of California, Davis, California 95616, USA
Am J Pathol 161:727-35. 2002..Although the malignant potential of PIN IV in mice has not been proven, GEM PIN is similar to human PIN. This PIN classification system is a first step toward a systematic evaluation of the biological potential of these lesions in GEM...
- E mu-BRD2 transgenic mice develop B-cell lymphoma and leukemiaRebecca J Greenwald
Department of Pathology, Immunology Research Division, Brigham and Women s Hospital, Harvard Medcial School, Boston, MA, USA
Blood 103:1475-84. 2004..This report is the first to describe a transgenic mouse model for constitutive expression of a protein with more than one bromodomain...
- Effect of c-neu/ ErbB2 expression levels on estrogen receptor alpha-dependent proliferation in mammary epithelial cells: implications for breast cancer biologyGopalan Shyamala
Lawrence Berkeley National Laboratory, Life Sciences Division, University of California, Berkeley, California, 94720, USA
Cancer Res 66:10391-8. 2006..Therefore, depending on the physiologic setting, ductal morphogenesis will be compromised both in the absence and overexpression of c-neu, thus explaining the paradox...
- Mouse mammary tumor biology: a short historyRobert D Cardiff
Center for Comparative Medicine, Department of Pathology and Laboratory Medicine, School of Medicine, University of California, Davis, California 95616, USA
Adv Cancer Res 98:53-116. 2007..If Einstein was correct in that "we stand on the shoulders of giants," the neophytes should meet their giants...
- Mouse models of human breast cancerRobert D Cardiff
Center for Comparative Medicine, Department of Medical Pathology, University of California-Davis, 95616, USA
Comp Med 53:250-3. 2003
- Mouse models of human cancers (part 3)Alexander D Borowsky
Center for Comparative Medicine, University of California-Davis, 95615, USA
Comp Med 54:258-70. 2004
- Contributions of mouse biology to breast cancer researchRobert D Cardiff
University of California, Davis, USA
Comp Med 52:12-31. 2002
- Enhanced in vivo bioluminescence imaging using liposomal luciferin delivery systemAzadeh Kheirolomoom
University of California, Davis, Department of Biomedical Engineering, 451 East Health Sciences Drive, Davis, CA 95616, USA
J Control Release 141:128-36. 2010....
- Suppression of the negative regulator LRIG1 contributes to ErbB2 overexpression in breast cancerJamie K Miller
School of Medicine, Davis Cancer Center, University of California at Davis, Sacramento, California 95817, USA
Cancer Res 68:8286-94. 2008..Moreover, our observations point to the existence of a feed-forward regulatory loop in breast tumor cells where aberrant ErbB2 signaling suppresses LRIG1 protein levels, which in turn contributes to ErbB2 overexpression...
- SLITs suppress tumor growth in vivo by silencing Sdf1/Cxcr4 within breast epitheliumRebecca Marlow
Department of Molecular, Cell and Developmental Biology, University of California, Santa Cruz, California 95064, USA
Cancer Res 68:7819-27. 2008..These studies classify Slits as negative regulators of Sdf1 and Cxcr4 and identify a molecular signature in hyperplastic breast lesions that signifies inappropriate up-regulation of key prometastatic genes...
- Overexpression of progesterone receptor A isoform in mice leads to endometrial hyperproliferation, hyperplasia and atypiaM C Fleisch
Life Sciences Division, Lawrence Berkeley National Laboratory, University of California, Berkeley, CA 94720, USA
Mol Hum Reprod 15:241-9. 2009..Imbalanced expression of the two isoforms of PR in a transgenic model reveals multiple derangements in the regulation of uterine physiology, resulting in various pathologies including hyperplasias...
- Precancer: sequentially acquired or predetermined?Robert D Cardiff
University of California, Davis, CA 95616, USA
Toxicol Pathol 38:171-9. 2010..If correct, this model suggests that "progression" to malignancy is epigenetic. Further, future assessment of biological potential will involve identification and genetic analysis of the progenitor cell populations...
- Mouse models of human cancers (Part 2)Jose J Galvez
Department of Pathology and Laboratory Medicine, University of Cincinnati and Cincinnati Veterans Affairs Medical Center, Ohio 45267-0529, USA
Comp Med 54:13-5. 2004
- Effects of FVB/NJ and C57Bl/6J strain backgrounds on mammary tumor phenotype in inducible nitric oxide synthase deficient miceSarah A Davie
Moores UCSD Cancer Center, Department of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, San Diego, CA 92093 0063, USA
Transgenic Res 16:193-201. 2007..Our data suggest that PyMT in the B6 background provides a useful model for the study of inflammation-induced breast cancer...
- Tumor promotion by caspase-resistant retinoblastoma proteinHelena L Borges
Division of Hematology Oncology, Moores Cancer Center, School of Medicine, University of California at San Diego, La Jolla, CA 92093, USA
Proc Natl Acad Sci U S A 102:15587-92. 2005..These results suggest that RB tumor suppressor function, i.e., inhibition of proliferation, is inactivated by phosphorylation, whereas RB tumor promoting function, i.e., inhibition of apoptosis, is inactivated by caspase cleavage...
- T-cadherin supports angiogenesis and adiponectin association with the vasculature in a mouse mammary tumor modelLionel W Hebbard
Burnham Institute for Medical Research, La Jolla, California 92037, USA
Cancer Res 68:1407-16. 2008....
- Differential sensitivity of mouse epithelial tissues to the polyomavirus middle T oncogeneGrace Cecena
OncoDevelopmental Biology Program, Cancer Research Center, The Burnham Institute, La Jolla, CA 92037, USA
Am J Pathol 168:310-20. 2006..The variety of responses of different epithelia to PyMT demonstrates the importance of the differentiated state in interpreting oncogenic signals...
- Cooperativity of Nkx3.1 and Pten loss of function in a mouse model of prostate carcinogenesisMinjung J Kim
Center for Advanced Biotechnology and Medicine and Department of Neuroscience, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, Piscataway, NJ 08854, USA
Proc Natl Acad Sci U S A 99:2884-9. 2002..Our findings underscore the significance of interactions between tissue-specific regulators such as Nkx3.1 and broad-spectrum tumor suppressors such as Pten in contributing to the distinct phenotypes of different cancers...
- Hypoxia-inducible factor-1 facilitates cervical cancer progression in human papillomavirus type 16 transgenic miceZhi Hong Lu
Division of Urologic Surgery, Washington University School of Medicine, St Louis, Missouri, USA
Am J Pathol 171:667-81. 2007....
- Distinct ErbB-2 coupled signaling pathways promote mammary tumors with unique pathologic and transcriptional profilesBabette Schade
Molecular Oncology Group, McGill University Health Centre, McGill University, Montreal, Quebec, Canada
Cancer Res 67:7579-88. 2007..Taken together, these findings indicate that activation of distinct Neu-coupled signaling pathways has an important impact on the biological behavior of Neu-induced tumors...
- Nkx3.1 mutant mice recapitulate early stages of prostate carcinogenesisMinjung J Kim
Department of Neuroscience, Center for Advanced Biotechnology and Medicine, 679 Hoes Lane, Piscataway, NJ 08854, USA
Cancer Res 62:2999-3004. 2002..1 mutant mice accurately model early stages of prostate carcinogenesis. More generally, our tissue recombination assay provides an empirical test to examine the relationship of PIN to prostate carcinoma...
- ShcA signalling is essential for tumour progression in mouse models of human breast cancerJosie Ursini-Siegel
Department of Medicine, McGill University, McGill University Health Center, Montreal, Quebec, Canada
EMBO J 27:910-20. 2008..This study is the first to directly demonstrate that signalling downstream from the ShcA adaptor protein is critical for breast cancer development...
- Phosphatase and tensin homologue deleted on chromosome 10 deficiency accelerates tumor induction in a mouse model of ErbB-2 mammary tumorigenesisNathalie Dourdin
Molecular Oncology Group, McGill University Health Center, Montreal, Quebec, Canada
Cancer Res 68:2122-31. 2008....
- Prostatic intraepithelial neoplasia in mice with conditional disruption of the retinoid X receptor alpha allele in the prostate epitheliumJiapeng Huang
Department of Biochemistry and Molecular Biology, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA
Cancer Res 62:4812-9. 2002....
- Mammary epithelial-specific disruption of the focal adhesion kinase blocks mammary tumor progressionHicham Lahlou
Molecular Oncology Group, McGill University, Royal Victoria Hospital, room H5 21, 687 Pine Avenue West, Montreal, QC, Canada H3A 1A1
Proc Natl Acad Sci U S A 104:20302-7. 2007..This dramatic block in tumor progression was further correlated with impaired mammary epithelial proliferation. These observations provide direct evidence that FAK plays a critical role in mammary tumor progression...
- Activation of different Wnt/beta-catenin signaling components in mammary epithelium induces transdifferentiation and the formation of pilar tumorsKeiko Miyoshi
Laboratory of Genetics and Physiology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, MD 20892, USA
Oncogene 21:5548-56. 2002....
- Dissociation of epithelial and neuroendocrine carcinoma lineages in the transgenic adenocarcinoma of mouse prostate model of prostate cancerTeresa Chiaverotti
Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA, USA
Am J Pathol 172:236-46. 2008..Adenocarcinomas were not seen in our cohort. Thus, neuroendocrine carcinomas are the principal malignancy in this model and may develop from bipotential progenitor cells at an early stage of prostate tumorigenesis...
- Insights from transgenic mouse models of ERBB2-induced breast cancerJosie Ursini Siegel
Departments of Medicine and Biochemistry, McGill University, Montreal, Quebec, Canada
Nat Rev Cancer 7:389-97. 2007..In addition, a mouse model has recently been described that accurately recapitulates many of the hallmarks associated with the early stages of the human disease...
- Acceleration of mouse mammary tumor virus-induced murine mammary tumorigenesis by a p53 172H transgene: influence of FVB background on tumor latency and identification of novel sites of proviral insertionGouri Chatterjee
Department of Pathology, Yale University School of Medicine, New Haven, CT 06520 8023 USA
Am J Pathol 161:2241-53. 2002..1). These may represent cellular functions that are likely not deregulated by mutation in p53...
- Loss of Nrdp1 enhances ErbB2/ErbB3-dependent breast tumor cell growthLily Yen
University of California Davis Cancer Center, Sacramento, CA 95817 2305, USA
Cancer Res 66:11279-86. 2006..Our observations suggest that Nrdp1-mediated ErbB3 degradation suppresses cellular growth and motility, and that Nrdp1 loss in breast tumors may promote tumor progression by augmenting ErbB2/ErbB3 signaling...
- Spontaneous pituitary abnormalities and mammary hyperplasia in FVB/NCr mice: implications for mouse modelingLalage M Wakefield
Laboratory of Cell Regulation and Carcinogenesis, National Cancer Institute, Bethesda, Maryland 20892, USA
Comp Med 53:424-32. 2003..This high prevalence of pituitary abnormalities and their effects on the mammary gland have important consequences for the interpretation of new phenotypes generated in transgenic models using this mouse substrain...
- A critical role for p27kip1 gene dosage in a mouse model of prostate carcinogenesisHui Gao
Center for Advanced Biotechnology and Medicine, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, Piscataway, NJ 08854, USA
Proc Natl Acad Sci U S A 101:17204-9. 2004..Our findings suggest that p27(kip1) possesses dosage-sensitive positive as well as negative modulatory roles in prostate cancer progression...
- MYC inactivation uncovers pluripotent differentiation and tumour dormancy in hepatocellular cancerCatherine M Shachaf
Division of Medical Oncology, Department of Medicine, Stanford University, California 94305, USA
Nature 431:1112-7. 2004....
- Developmental context determines latency of MYC-induced tumorigenesisShelly Beer
Division of Oncology, Department of Medicine, Stanford University, Stanford, California, USA
PLoS Biol 2:e332. 2004..Adult somatic cells have evolved mechanisms to prevent individual oncogenes from initiating cellular growth, DNA replication, and mitotic cellular division alone, thereby preventing any single genetic event from inducing tumorigenesis...
- Mice expressing SV40 T antigen directed by the intestinal trefoil factor promoter develop tumors resembling human small cell carcinoma of the colonJames R Gum
Department of Veterans Affairs Medical Center, 4150 Clement Street, San Francisco, CA 94121, USA
Mol Cancer Res 2:504-13. 2004..ITFTag tumors closely resemble human small cell carcinomas of the colon, suggesting the possibility that these tumors might be derived from the enteroendocrine cell lineage as well...
- Deregulation of Stat5 expression and activation causes mammary tumors in transgenic miceElena Iavnilovitch
Institute of Animal Science, Agricultural Research Organization, Volcani Center, Bet-Dagan, Israel
Int J Cancer 112:607-19. 2004..The transactivation function of Stat5 is involved in the determination of tumors with a more differentiated phenotype...
- pRb inactivation in mammary cells reveals common mechanisms for tumor initiation and progression in divergent epitheliaKarl Simin
Department of Genetics, Lineberger Comprehensive Cancer Center, The University of North Carolina School of Medicine, Chapel Hill, USA
PLoS Biol 2:E22. 2004..Further, this study has produced a highly penetrant breast cancer model based on aberrations commonly observed in the human disease...
- Prostate pathology of genetically engineered mice: definitions and classification. The consensus report from the Bar Harbor meeting of the Mouse Models of Human Cancer Consortium Prostate Pathology CommitteeScott B Shappell
Department of Pathology and Vanderbilt Prostate Cancer Center, Vanderbilt University Medical Center, Nashville, TN 37210, USA
Cancer Res 64:2270-305. 2004....
- Activation of Akt-1 (PKB-alpha) can accelerate ErbB-2-mediated mammary tumorigenesis but suppresses tumor invasionJohn N Hutchinson
MOBIX, McMaster University, Hamilton, Ontario, Canada
Cancer Res 64:3171-8. 2004..Taken together, these observations suggest that activation of Akt-1 during ErbB-2-induced mammary tumorigenesis may have opposing effects on tumor growth and metastatic progression...
- The transcriptional repressor Snail promotes mammary tumor recurrenceSusan E Moody
Department of Cancer Biology, Abramson Family Cancer Research Institute, University of Pennsylvania School of Medicine, Philadelphia, 19104, USA
Cancer Cell 8:197-209. 2005..In aggregate, our observations strongly implicate Snail in the process of breast cancer recurrence...
- Oncogenic signaling pathways activated in DMBA-induced mouse mammary tumorsNicolas Currier
Boston University School of Medicine, Department of Medicine, Boston, MA, USA
Toxicol Pathol 33:726-37. 2005..These data suggest that environmental carcinogens can produce long-lasting alterations in growth and anti-apoptotic pathways, leading to mammary tumorigenesis...
- Gene expression profiling of neu-induced mammary tumors from transgenic mice reveals genetic and morphological similarities to ErbB2-expressing human breast cancersEran R Andrechek
Institute for Molecular Biology and Biotechnology, Department of Biology, McMaster University, Hamilton, Canada
Cancer Res 63:4920-6. 2003..Taken together, these results illustrate the similarity of the endogenously regulated Neu tumor model to the human disease...
- Somatic inactivation of E-cadherin and p53 in mice leads to metastatic lobular mammary carcinoma through induction of anoikis resistance and angiogenesisPatrick W B Derksen
Division of Molecular Biology, Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands
Cancer Cell 10:437-49. 2006..Moreover, loss of E-cadherin induced anoikis resistance and facilitated angiogenesis, thus promoting metastatic disease. Our results suggest that loss of E-cadherin contributes to both mammary tumor initiation and metastasis...
- Conditional activation of Neu in the mammary epithelium of transgenic mice results in reversible pulmonary metastasisSusan E Moody
Department of Cancer Biology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
Cancer Cell 2:451-61. 2002....
- Angiogenic acceleration of Neu induced mammary tumor progression and metastasisRobert G Oshima
OncoDevelopmental Biology Program, The Burnham Institute, La Jolla, California 92037, USA
Cancer Res 64:169-79. 2004..They also reinforce in vivo the importance of activated Neu in causing disorganization of mammary luminal epithelial cell junctions and provide support for an invasion-independent mechanism of metastasis...
- Impact of p53 loss on reversal and recurrence of conditional Wnt-induced tumorigenesisEdward J Gunther
Department of Cancer Biology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6160, USA
Genes Dev 17:488-501. 2003....
- Activation of beta-catenin in prostate epithelium induces hyperplasias and squamous transdifferentiationBrian Bierie
Laboratory of Genetics and Physiology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
Oncogene 22:3875-87. 2003..This suggests that the transdifferentiation into squamous metaplasias is an early response of endoderm-derived cells to beta-catenin, and that the development of intra-acinous hyperplasias or neoplastic foci is a later event...
- Mammary tumorigenesis following transgenic expression of a dominant negative CHK2 mutantEunice L Kwak
Massachusetts General Hospital Cancer Center and Harvard Medical School, Charlestown, Massachusetts 02129, USA
Cancer Res 66:1923-8. 2006..The increased rate of tumor formation in MMTV-CHK2-D347A mice, compared with the relatively low incidence in chk2-null mice, provides a model to study modifiers of CHK2-dependent transformation...
- Mouse mammary tumor virus c-rel transgenic mice develop mammary tumorsRaphaelle Romieu-Mourez
Department of Biochemistry, Boston University Medical School, Boston, Massachusetts 02118, USA
Mol Cell Biol 23:5738-54. 2003..These results indicate for the first time that dysregulated expression of c-Rel, as observed in breast cancers, is capable of contributing to mammary tumorigenesis...
- Selective evolution of stromal mesenchyme with p53 loss in response to epithelial tumorigenesisReginald Hill
Curriculum in Genetics and Molecular Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
Cell 123:1001-11. 2005..This interaction imposes strong selective pressure yielding a highly proliferative mesenchyme that has undergone p53 loss...
- Heterogeneous tumor evolution initiated by loss of pRb function in a preclinical prostate cancer modelReginald Hill
Curriculum in Genetics and Molecular Biology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
Cancer Res 65:10243-54. 2005..Given that this analysis models the apparent timing of highly penetrant events in human prostate cancer, observed effects may recapitulate the natural evolution of prostate cancer development...
- Prostatic intraepithelial neoplasia and intestinal metaplasia in prostates of probasin-RAS transgenic miceAlexis Scherl
Department of Molecular Genetics, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York, USA
Prostate 59:448-59. 2004..CONCLUSIONS: The Pb-RAS mouse model could be useful for elucidating the early events in prostate carcinogenesis, as well as for studying the mechanisms and potential prostate cancer relevance of intestinal metaplasia...
- PRECLINICAL MODELS OF BREAST CANCERRobert Cardiff; Fiscal Year: 2003..The theme of the workshop is "High Throughput Phenotyping: From Mouse to Molecule in One Day!" It will allow the student to examine and compare the best and fastest phenotyping technology currently available. ..
- BIOLOGY OF NEOPLASTIC TRANSFORMATION IN BREAST CANCERRobert Cardiff; Fiscal Year: 2005..The goal of this project is to develop a well-characterized model for breast cancer development and to dissect the molecular pathways involved in tumor formation. ..
- 25TH IABCR CONGRESS CONFERENCE: PERSONALIZED BREAST CANCER THERAPYRobert Cardiff; Fiscal Year: 2006..The session will also include a plenary lecture from Dr. A Ullrich who pioneered the concept of targeting the HER2 oncogene in the treatment of breast cancer. ..