Robert D Cardiff

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Precancer in mice: animal models used to understand, prevent, and treat human precancers
    Robert D Cardiff
    The UCD Center for Comparative Medicine, University of California, Davis, Davis, California 95616, USA
    Toxicol Pathol 34:699-707. 2006
  2. ncbi request reprint Rapamycin inhibits growth of premalignant and malignant mammary lesions in a mouse model of ductal carcinoma in situ
    Ruria Namba
    Department of Pathology and Laboratory Medicine, School of Medicine, University of California, Davis, Sacramento, CA 95817, USA
    Clin Cancer Res 12:2613-21. 2006
  3. ncbi request reprint Preclinical imaging of mammary intraepithelial neoplasia with positron emission tomography
    Craig K Abbey
    Department of Biomedical Engineering, University of California, Davis, CA 95616, USA
    J Mammary Gland Biol Neoplasia 11:137-49. 2006
  4. pmc Mammary carcinoma behavior is programmed in the precancer stem cell
    Patrizia Damonte
    Department of Pathology and Laboratory Medicine, Center for Comparative Medicine, UC Davis, County Road 98 and Hutchison Drive, Davis, California 95616, USA
    Breast Cancer Res 10:R50. 2008
  5. pmc Ultrasound increases nanoparticle delivery by reducing intratumoral pressure and increasing transport in epithelial and epithelial-mesenchymal transition tumors
    Katherine D Watson
    Department of Biomedical Engineering, University of California, Davis, California 95616, USA
    Cancer Res 72:1485-93. 2012
  6. pmc EMT tumorigenesis in the mouse mammary gland
    Patrizia Damonte
    Center for Comparative Medicine, University of California at Davis, Davis, CA 95616, USA
    Lab Invest 87:1218-26. 2007
  7. pmc Selective estrogen receptor modulators inhibit growth and progression of premalignant lesions in a mouse model of ductal carcinoma in situ
    Ruria Namba
    Department of Pathology and Laboratory Medicine, School of Medicine, University of California, Davis, Sacramento, CA, USA
    Breast Cancer Res 7:R881-9. 2005
  8. pmc Accumulation, internalization and therapeutic efficacy of neuropilin-1-targeted liposomes
    Eric E Paoli
    University of California, Davis, Department of Biomedical Engineering, 451 Health Sciences Drive, Davis, CA 95616, USA Electronic address
    J Control Release 178:108-17. 2014
  9. ncbi request reprint Mouse mammary tumor biology: a short history
    Robert D Cardiff
    Center for Comparative Medicine, Department of Pathology and Laboratory Medicine, School of Medicine, University of California, Davis, California 95616, USA
    Adv Cancer Res 98:53-116. 2007
  10. ncbi request reprint Effect of c-neu/ ErbB2 expression levels on estrogen receptor alpha-dependent proliferation in mammary epithelial cells: implications for breast cancer biology
    Gopalan Shyamala
    Lawrence Berkeley National Laboratory, Life Sciences Division, University of California, Berkeley, California, 94720, USA
    Cancer Res 66:10391-8. 2006

Detail Information

Publications80

  1. ncbi request reprint Precancer in mice: animal models used to understand, prevent, and treat human precancers
    Robert D Cardiff
    The UCD Center for Comparative Medicine, University of California, Davis, Davis, California 95616, USA
    Toxicol Pathol 34:699-707. 2006
    ..These studies suggest that genetically engineered mice are very useful preclinical models for chemoprevention and therapy...
  2. ncbi request reprint Rapamycin inhibits growth of premalignant and malignant mammary lesions in a mouse model of ductal carcinoma in situ
    Ruria Namba
    Department of Pathology and Laboratory Medicine, School of Medicine, University of California, Davis, Sacramento, CA 95817, USA
    Clin Cancer Res 12:2613-21. 2006
    ..Both of these models were derived from mammary lesions in Tg(MMTV-PyV-mT) mice...
  3. ncbi request reprint Preclinical imaging of mammary intraepithelial neoplasia with positron emission tomography
    Craig K Abbey
    Department of Biomedical Engineering, University of California, Davis, CA 95616, USA
    J Mammary Gland Biol Neoplasia 11:137-49. 2006
    ..We conclude with a brief survey of emerging approaches in small-animal PET imaging...
  4. pmc Mammary carcinoma behavior is programmed in the precancer stem cell
    Patrizia Damonte
    Department of Pathology and Laboratory Medicine, Center for Comparative Medicine, UC Davis, County Road 98 and Hutchison Drive, Davis, California 95616, USA
    Breast Cancer Res 10:R50. 2008
    ..Transition to carcinoma has a consistent latency for each line, and three of the lines also exhibit pulmonary metastatic potential...
  5. pmc Ultrasound increases nanoparticle delivery by reducing intratumoral pressure and increasing transport in epithelial and epithelial-mesenchymal transition tumors
    Katherine D Watson
    Department of Biomedical Engineering, University of California, Davis, California 95616, USA
    Cancer Res 72:1485-93. 2012
    ..Taken together, our results illustrate how ultrasound can be used to enhance nanoparticle accumulation in tumors by reducing their intratumoral pressure and increasing their vascular permeability...
  6. pmc EMT tumorigenesis in the mouse mammary gland
    Patrizia Damonte
    Center for Comparative Medicine, University of California at Davis, Davis, CA 95616, USA
    Lab Invest 87:1218-26. 2007
    ..This suggests that potential EMT tumors are best designated EMT-phenotype tumors...
  7. pmc Selective estrogen receptor modulators inhibit growth and progression of premalignant lesions in a mouse model of ductal carcinoma in situ
    Ruria Namba
    Department of Pathology and Laboratory Medicine, School of Medicine, University of California, Davis, Sacramento, CA, USA
    Breast Cancer Res 7:R881-9. 2005
    ..We studied the ovarian-hormone-responsiveness of one of the lines with a particular focus on the effects of two related SERMs, tamoxifen and ospemifene...
  8. pmc Accumulation, internalization and therapeutic efficacy of neuropilin-1-targeted liposomes
    Eric E Paoli
    University of California, Davis, Department of Biomedical Engineering, 451 Health Sciences Drive, Davis, CA 95616, USA Electronic address
    J Control Release 178:108-17. 2014
    ..Taken together, our results demonstrate that a carboxyl-terminated RXXR peptide sequence, conjugated to liposomes at a concentration of 0.63mol%, retains long circulation but enhances binding and internalization, and reduces toxicity. ..
  9. ncbi request reprint Mouse mammary tumor biology: a short history
    Robert D Cardiff
    Center for Comparative Medicine, Department of Pathology and Laboratory Medicine, School of Medicine, University of California, Davis, California 95616, USA
    Adv Cancer Res 98:53-116. 2007
    ..If Einstein was correct in that "we stand on the shoulders of giants," the neophytes should meet their giants...
  10. ncbi request reprint Effect of c-neu/ ErbB2 expression levels on estrogen receptor alpha-dependent proliferation in mammary epithelial cells: implications for breast cancer biology
    Gopalan Shyamala
    Lawrence Berkeley National Laboratory, Life Sciences Division, University of California, Berkeley, California, 94720, USA
    Cancer Res 66:10391-8. 2006
    ..Therefore, depending on the physiologic setting, ductal morphogenesis will be compromised both in the absence and overexpression of c-neu, thus explaining the paradox...
  11. pmc Copper-doxorubicin as a nanoparticle cargo retains efficacy with minimal toxicity
    Azadeh Kheirolomoom
    Department of Biomedical Engineering, 451 East Health Sciences Drive, School of Medicine, University of California, Davis, Davis, California 95616, United States
    Mol Pharm 7:1948-58. 2010
    ..After the 28-day course of therapy, syngeneic tumors regressed to a premalignant phenotype of ∼(1 mm)(3) or could not be detected...
  12. pmc Enhanced in vivo bioluminescence imaging using liposomal luciferin delivery system
    Azadeh Kheirolomoom
    University of California, Davis, Department of Biomedical Engineering, 451 East Health Sciences Drive, Davis, CA 95616, USA
    J Control Release 141:128-36. 2010
    ....
  13. pmc The use of mouse models of breast cancer and quantitative image analysis to evaluate hormone receptor antigenicity after microwave-assisted formalin fixation
    Jesse A Engelberg
    Center for Comparative Medicine, University of California, Davis, California JAE, LJTY, NEH, RDC
    J Histochem Cytochem 62:319-34. 2014
    ..The results demonstrated that microwave-assisted formalin fixation can standardize fixation times to 1 hr and produce immunohistochemistry that is in every way commensurate with longer conventional fixation methods. ..
  14. pmc Three interrelated themes in current breast cancer research: gene addiction, phenotypic plasticity, and cancer stem cells
    Robert D Cardiff
    Department of Pathology, Center for Comparative Medicine, University of California, Davis, County Road 98 and Hutchison Drive, Davis, CA 95616, USA
    Breast Cancer Res 13:216. 2011
    ..These themes cooperate in breast cancer, as induction of epithelial-to-mesenchymal transition enhances self-renewal and expression of cancer stem cells, which are believed to facilitate tumor resistance...
  15. ncbi request reprint Validation: the new challenge for pathology
    Robert D Cardiff
    Center for Comparative Medicine, University of California, Davis, Davis, California 95616, USA
    Toxicol Pathol 32:31-9. 2004
    ..The phenotypes can be placed into structural and functional clusters with shared characteristics leading to the concepts of Pathway Pathology: tumor phenotype reflects the genotype...
  16. pmc In vivo positron-emission tomography imaging of progression and transformation in a mouse model of mammary neoplasia
    Craig K Abbey
    Department of Biomedical Engineering, University of California, One Shields Avenue, Davis, CA 95616, USA
    Proc Natl Acad Sci U S A 101:11438-43. 2004
    ..Furthermore, quantitative markers of disease extracted from the images can be used to track proliferation and progression in vivo over multiple time points...
  17. pmc SLITs suppress tumor growth in vivo by silencing Sdf1/Cxcr4 within breast epithelium
    Rebecca Marlow
    Department of Molecular, Cell and Developmental Biology, University of California, Santa Cruz, California 95064, USA
    Cancer Res 68:7819-27. 2008
    ..These studies classify Slits as negative regulators of Sdf1 and Cxcr4 and identify a molecular signature in hyperplastic breast lesions that signifies inappropriate up-regulation of key prometastatic genes...
  18. pmc Overexpression of progesterone receptor A isoform in mice leads to endometrial hyperproliferation, hyperplasia and atypia
    M C Fleisch
    Life Sciences Division, Lawrence Berkeley National Laboratory, University of California, Berkeley, CA 94720, USA
    Mol Hum Reprod 15:241-9. 2009
    ..Imbalanced expression of the two isoforms of PR in a transgenic model reveals multiple derangements in the regulation of uterine physiology, resulting in various pathologies including hyperplasias...
  19. pmc Effects of FVB/NJ and C57Bl/6J strain backgrounds on mammary tumor phenotype in inducible nitric oxide synthase deficient mice
    Sarah A Davie
    Moores UCSD Cancer Center, Department of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, San Diego, CA 92093 0063, USA
    Transgenic Res 16:193-201. 2007
    ..Our data suggest that PyMT in the B6 background provides a useful model for the study of inflammation-induced breast cancer...
  20. pmc Molecular analysis of metastasis in a polyomavirus middle T mouse model: the role of osteopontin
    Katayoun Alavi Jessen
    Department of Pathology, University of California, Davis, School of Medicine, Sacramento, California, USA
    Breast Cancer Res 6:R157-69. 2004
    ..In order to study metastatic disease, we employed the use of two related polyomavirus middle T transgenic mouse tumor transplant models of mammary carcinoma (termed Met and Db) that display significant differences in metastatic potential...
  21. pmc The membrane mucin MUC4 is elevated in breast tumor lymph node metastases relative to matched primary tumors and confers aggressive properties to breast cancer cells
    Heather C Workman
    Division of Basic Sciences, UC Davis Cancer Center, 4645 2ndAvenue, Sacramento, California 95817, USA
    Breast Cancer Res 11:R70. 2009
    ....
  22. pmc Heterogeneity of mammary lesions represent molecular differences
    Ruria Namba
    Department of Pathology and Laboratory Medicine, School of Medicine, University of California at Davis, Sacramento, CA 95817, USA
    BMC Cancer 6:275. 2006
    ..Each MIN-O line has distinguishable morphologies, metastatic potentials and estrogen dependencies...
  23. ncbi request reprint Syngeneic mouse mammary carcinoma cell lines: two closely related cell lines with divergent metastatic behavior
    Alexander D Borowsky
    Department of Medical Pathology and Laboratory Medicine, UC Davis School of Medicine, Sacramento, CA 95817, USA
    Clin Exp Metastasis 22:47-59. 2005
    ..Therefore, these two cell lines provide a stable, reproducible resource for the study of metastasis modulators, AKT molecular pathway interactions, and gene target and marker discovery...
  24. pmc Inflammation and atrophy precede prostatic neoplasia in a PhIP-induced rat model
    Alexander D Borowsky
    University of California and the Lawrence Livermore NationalLaboratory, USA
    Neoplasia 8:708-15. 2006
    ..Overall, these findings suggest that the pathogenesis of prostatic neoplasia in the PhIP-treated rat prostate proceeds from inflammation to postinflammatory proliferative atrophy to PIN...
  25. doi request reprint Structured reporting in anatomic pathology for coclinical trials: the caELMIR model
    Robert D Cardiff
    Center for Comparative Medicine and Center for Genomic Pathology, University of California, Davis, Davis, California 95616
    Cold Spring Harb Protoc 2014:32-43. 2014
    ..S. National Cancer Institute's (NCI's) Mouse Models of Human Cancers Consortium (MMHCC). ..
  26. ncbi request reprint Somatic mutation of p53 leads to estrogen receptor alpha-positive and -negative mouse mammary tumors with high frequency of metastasis
    Suh Chin J Lin
    Departments of Developmental and Cell Biology, University of California, Irvine, California 92697, USA
    Cancer Res 64:3525-32. 2004
    ..Thus, this tumor system reproduces many important features of human breast cancer and provides tools for the study of the origins of ERalpha-positive and -negative breast tumors in mice...
  27. doi request reprint Precancer: sequentially acquired or predetermined?
    Robert D Cardiff
    University of California, Davis, CA 95616, USA
    Toxicol Pathol 38:171-9. 2010
    ..If correct, this model suggests that "progression" to malignancy is epigenetic. Further, future assessment of biological potential will involve identification and genetic analysis of the progenitor cell populations...
  28. pmc Prostatic intraepithelial neoplasia in genetically engineered mice
    Jae Hak Park
    Center for Comparative Medicine and Department of Medical Pathology, University of California, Davis, California 95616, USA
    Am J Pathol 161:727-35. 2002
    ..Although the malignant potential of PIN IV in mice has not been proven, GEM PIN is similar to human PIN. This PIN classification system is a first step toward a systematic evaluation of the biological potential of these lesions in GEM...
  29. ncbi request reprint Manual Immunohistochemistry Staining of Mouse Tissues Using the Avidin-Biotin Complex (ABC) Technique
    Robert D Cardiff
    Center for Comparative Medicine and Center for Genomic Pathology, University of California, Davis, Davis, California 95616
    Cold Spring Harb Protoc 2014:pdb.prot073429. 2014
    ..The method utilizes the high avidity of biotin for avidin, which allows formation of a strong bond. The reagents described in this technique produce a gold/brown reaction product that identifies the epitope of interest. ..
  30. ncbi request reprint Analysis of mouse model pathology: a primer for studying the anatomic pathology of genetically engineered mice
    Robert D Cardiff
    Center for Comparative Medicine and Center for Genomic Pathology, University of California, Davis, Davis, California 95616
    Cold Spring Harb Protoc 2014:pdb.top069922. 2014
    ..Because GEMMs are unique experimental subjects, some of the more common pitfalls are discussed. Many of these errors can be avoided with attention to detail and continuous quality assurance. ..
  31. ncbi request reprint Manual hematoxylin and eosin staining of mouse tissue sections
    Robert D Cardiff
    Center for Comparative Medicine and Center for Genomic Pathology, University of California, Davis, Davis, California 95616
    Cold Spring Harb Protoc 2014:pdb.prot073411. 2014
    ..This includes frequent reagent changes as well as the use of "in-date" reagents. Appropriate color in a good H&E stain allows for identification of many tissue subtleties that are necessary for accurate diagnosis. ..
  32. pmc Quantitation of fixative-induced morphologic and antigenic variation in mouse and human breast cancers
    Robert D Cardiff
    Center for Comparative Medicine, University of California, Davis, CA 95616, USA
    Lab Invest 93:480-97. 2013
    ..The strong cross-linker fixatives, such as formalin, consistently ranked higher than weak cross-linker, coagulant and combination fixatives in both the morphometric and immunohistochemical parameters...
  33. pmc Pathway pathology: histological differences between ErbB/Ras and Wnt pathway transgenic mammary tumors
    Andrea Rosner
    Center for Comparative Medicine, University of California, Davis 95616, USA
    Am J Pathol 161:1087-97. 2002
    ....
  34. ncbi request reprint Epilog: comparative medicine, one medicine and genomic pathology
    Robert D Cardiff
    Department of Pathology and Laboratory Medicine, Center for Comparative Medicine, University of California, Davis, CA 95616, USA
    Breast Dis 28:107-10. 2007
    ..This issue examines these contributions and opens the way for the examination of other mammalian species. The development of a new discipline, Genomic Pathology, can now be anticipated...
  35. ncbi request reprint Contributions of mouse biology to breast cancer research
    Robert D Cardiff
    University of California, Davis, USA
    Comp Med 52:12-31. 2002
  36. pmc Diet-induced metabolic change induces estrogen-independent allometric mammary growth
    Grace E Berryhill
    Department of Animal Science, University of California, Davis, CA 95616 8521, USA
    Proc Natl Acad Sci U S A 109:16294-9. 2012
    ..Our data demonstrate that diet-induced metabolic dysregulation, independently of ovarian function, stimulates allometric growth within the mammary glands via an IGF-IR-dependent mechanism...
  37. ncbi request reprint 'One medicine---one pathology': are veterinary and human pathology prepared?
    Robert D Cardiff
    Center for Comparative Medicine, University of California, Davis, CA 95616, USA
    Lab Invest 88:18-26. 2008
    ..The impending glut of new genetically engineered mice creates an urgent need for prepared investigators and pathologists...
  38. ncbi request reprint Epithelial to Mesenchymal Transition Tumors: Fallacious or Snail's Pace?
    Robert D Cardiff
    Center for Comparative Medicine, Department of Pathology and Laboratory Medicine, University of California, Davis School of Medicine, Davis, California 95616, USA
    Clin Cancer Res 11:8534-7. 2005
  39. ncbi request reprint Histopathology as a predictive biomarker: strengths and limitations
    Robert D Cardiff
    Department of Medical Pathology and Laboratory Medicine, University of California, Davis CA 95616, USA
    J Nutr 136:2673S-5S. 2006
  40. ncbi request reprint MYC inactivation uncovers pluripotent differentiation and tumour dormancy in hepatocellular cancer
    Catherine M Shachaf
    Division of Medical Oncology, Department of Medicine, Stanford University, California 94305, USA
    Nature 431:1112-7. 2004
    ....
  41. pmc Dissociation of epithelial and neuroendocrine carcinoma lineages in the transgenic adenocarcinoma of mouse prostate model of prostate cancer
    Teresa Chiaverotti
    Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA, USA
    Am J Pathol 172:236-46. 2008
    ..Adenocarcinomas were not seen in our cohort. Thus, neuroendocrine carcinomas are the principal malignancy in this model and may develop from bipotential progenitor cells at an early stage of prostate tumorigenesis...
  42. pmc Impact of p53 loss on reversal and recurrence of conditional Wnt-induced tumorigenesis
    Edward J Gunther
    Department of Cancer Biology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6160, USA
    Genes Dev 17:488-501. 2003
    ....
  43. pmc Phosphatase and tensin homologue deleted on chromosome 10 deficiency accelerates tumor induction in a mouse model of ErbB-2 mammary tumorigenesis
    Nathalie Dourdin
    Molecular Oncology Group, McGill University Health Center, Montreal, Quebec, Canada
    Cancer Res 68:2122-31. 2008
    ....
  44. pmc T-cadherin supports angiogenesis and adiponectin association with the vasculature in a mouse mammary tumor model
    Lionel W Hebbard
    Burnham Institute for Medical Research, La Jolla, California 92037, USA
    Cancer Res 68:1407-16. 2008
    ....
  45. ncbi request reprint Insights from transgenic mouse models of ERBB2-induced breast cancer
    Josie Ursini-Siegel
    Departments of Medicine and Biochemistry, McGill University, Montreal, Quebec, Canada
    Nat Rev Cancer 7:389-97. 2007
    ..In addition, a mouse model has recently been described that accurately recapitulates many of the hallmarks associated with the early stages of the human disease...
  46. pmc Hypoxia-inducible factor-1 facilitates cervical cancer progression in human papillomavirus type 16 transgenic mice
    Zhi Hong Lu
    Division of Urologic Surgery, Washington University School of Medicine, St Louis, Missouri, USA
    Am J Pathol 171:667-81. 2007
    ....
  47. pmc ShcA signalling is essential for tumour progression in mouse models of human breast cancer
    Josie Ursini-Siegel
    Department of Medicine, McGill University, McGill University Health Center, Montreal, Quebec, Canada
    EMBO J 27:910-20. 2008
    ..This study is the first to directly demonstrate that signalling downstream from the ShcA adaptor protein is critical for breast cancer development...
  48. pmc Mammary epithelial-specific disruption of the focal adhesion kinase blocks mammary tumor progression
    Hicham Lahlou
    Molecular Oncology Group, McGill University, Royal Victoria Hospital, room H5 21, 687 Pine Avenue West, Montreal, QC, Canada H3A 1A1
    Proc Natl Acad Sci U S A 104:20302-7. 2007
    ..This dramatic block in tumor progression was further correlated with impaired mammary epithelial proliferation. These observations provide direct evidence that FAK plays a critical role in mammary tumor progression...
  49. ncbi request reprint Distinct ErbB-2 coupled signaling pathways promote mammary tumors with unique pathologic and transcriptional profiles
    Babette Schade
    Molecular Oncology Group, McGill University Health Centre, McGill University, Montreal, Quebec, Canada
    Cancer Res 67:7579-88. 2007
    ..Taken together, these findings indicate that activation of distinct Neu-coupled signaling pathways has an important impact on the biological behavior of Neu-induced tumors...
  50. ncbi request reprint Loss of Nrdp1 enhances ErbB2/ErbB3-dependent breast tumor cell growth
    Lily Yen
    University of California Davis Cancer Center, Sacramento, CA 95817 2305, USA
    Cancer Res 66:11279-86. 2006
    ..Our observations suggest that Nrdp1-mediated ErbB3 degradation suppresses cellular growth and motility, and that Nrdp1 loss in breast tumors may promote tumor progression by augmenting ErbB2/ErbB3 signaling...
  51. pmc PPAR gamma signaling exacerbates mammary gland tumor development
    Enrique Saez
    The Salk Institute for Biological Studies, and Howard Hughes Medical Institute, La Jolla, California 92037, USA
    Genes Dev 18:528-40. 2004
    ..These results suggest that once an initiating event has taken place, increased PPAR gamma signaling serves as a tumor promoter in the mammary gland...
  52. ncbi request reprint Prostate pathology of genetically engineered mice: definitions and classification. The consensus report from the Bar Harbor meeting of the Mouse Models of Human Cancer Consortium Prostate Pathology Committee
    Scott B Shappell
    Department of Pathology and Vanderbilt Prostate Cancer Center, Vanderbilt University Medical Center, Nashville, TN 37210, USA
    Cancer Res 64:2270-305. 2004
    ....
  53. pmc pRb inactivation in mammary cells reveals common mechanisms for tumor initiation and progression in divergent epithelia
    Karl Simin
    Department of Genetics, Lineberger Comprehensive Cancer Center, The University of North Carolina School of Medicine, Chapel Hill, USA
    PLoS Biol 2:E22. 2004
    ..Further, this study has produced a highly penetrant breast cancer model based on aberrations commonly observed in the human disease...
  54. ncbi request reprint Angiogenic acceleration of Neu induced mammary tumor progression and metastasis
    Robert G Oshima
    OncoDevelopmental Biology Program, The Burnham Institute, La Jolla, California 92037, USA
    Cancer Res 64:169-79. 2004
    ..They also reinforce in vivo the importance of activated Neu in causing disorganization of mammary luminal epithelial cell junctions and provide support for an invasion-independent mechanism of metastasis...
  55. ncbi request reprint Spontaneous pituitary abnormalities and mammary hyperplasia in FVB/NCr mice: implications for mouse modeling
    Lalage M Wakefield
    Laboratory of Cell Regulation and Carcinogenesis, National Cancer Institute, Bethesda, Maryland 20892, USA
    Comp Med 53:424-32. 2003
    ..This high prevalence of pituitary abnormalities and their effects on the mammary gland have important consequences for the interpretation of new phenotypes generated in transgenic models using this mouse substrain...
  56. ncbi request reprint Gene expression profiling of neu-induced mammary tumors from transgenic mice reveals genetic and morphological similarities to ErbB2-expressing human breast cancers
    Eran R Andrechek
    Institute for Molecular Biology and Biotechnology, Department of Biology, McMaster University, Hamilton, Canada
    Cancer Res 63:4920-6. 2003
    ..Taken together, these results illustrate the similarity of the endogenously regulated Neu tumor model to the human disease...
  57. ncbi request reprint Activation of beta-catenin in prostate epithelium induces hyperplasias and squamous transdifferentiation
    Brian Bierie
    Laboratory of Genetics and Physiology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Oncogene 22:3875-87. 2003
    ..This suggests that the transdifferentiation into squamous metaplasias is an early response of endoderm-derived cells to beta-catenin, and that the development of intra-acinous hyperplasias or neoplastic foci is a later event...
  58. pmc Transforming growth factor beta signaling impairs Neu-induced mammary tumorigenesis while promoting pulmonary metastasis
    Peter M Siegel
    Cell Biology Program and Howard Hughes Medical Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 100:8430-5. 2003
    ....
  59. ncbi request reprint Conditional activation of Neu in the mammary epithelium of transgenic mice results in reversible pulmonary metastasis
    Susan E Moody
    Department of Cancer Biology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Cancer Cell 2:451-61. 2002
    ....
  60. pmc Acceleration of mouse mammary tumor virus-induced murine mammary tumorigenesis by a p53 172H transgene: influence of FVB background on tumor latency and identification of novel sites of proviral insertion
    Gouri Chatterjee
    Department of Pathology, Yale University School of Medicine, New Haven, CT 06520 8023 USA
    Am J Pathol 161:2241-53. 2002
    ..1). These may represent cellular functions that are likely not deregulated by mutation in p53...
  61. ncbi request reprint Fibroblast growth factor 8 isoform B overexpression in prostate epithelium: a new mouse model for prostatic intraepithelial neoplasia
    Zhigang Song
    Department of Pathology, University of Southern California, Keck School of Medicine, Los Angeles, California 90033, USA
    Cancer Res 62:5096-105. 2002
    ..These transgenic mice represent a "natural" animal model for investigating the mechanism of development and progression of prostatic diseases, such as prostatic hyperplasia and preneoplastic lesions...
  62. ncbi request reprint Prostatic intraepithelial neoplasia in mice with conditional disruption of the retinoid X receptor alpha allele in the prostate epithelium
    Jiapeng Huang
    Department of Biochemistry and Molecular Biology, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA
    Cancer Res 62:4812-9. 2002
    ....
  63. ncbi request reprint Activation of different Wnt/beta-catenin signaling components in mammary epithelium induces transdifferentiation and the formation of pilar tumors
    Keiko Miyoshi
    Laboratory of Genetics and Physiology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, MD 20892, USA
    Oncogene 21:5548-56. 2002
    ....
  64. ncbi request reprint Prostatic intraepithelial neoplasia and intestinal metaplasia in prostates of probasin-RAS transgenic mice
    Alexis Scherl
    Department of Molecular Genetics, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York, USA
    Prostate 59:448-59. 2004
    ..Activation of the RAS pathway has been implicated in the pathogenesis of many types of human cancers, including prostate cancer. Here we employed a transgenic approach to assess the potential contribution of RAS to prostate carcinogenesis...
  65. pmc Cooperativity of Nkx3.1 and Pten loss of function in a mouse model of prostate carcinogenesis
    Minjung J Kim
    Center for Advanced Biotechnology and Medicine and Department of Neuroscience, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, Piscataway, NJ 08854, USA
    Proc Natl Acad Sci U S A 99:2884-9. 2002
    ..Our findings underscore the significance of interactions between tissue-specific regulators such as Nkx3.1 and broad-spectrum tumor suppressors such as Pten in contributing to the distinct phenotypes of different cancers...
  66. ncbi request reprint Activation of Akt-1 (PKB-alpha) can accelerate ErbB-2-mediated mammary tumorigenesis but suppresses tumor invasion
    John N Hutchinson
    MOBIX, McMaster University, Hamilton, Ontario, Canada
    Cancer Res 64:3171-8. 2004
    ..Taken together, these observations suggest that activation of Akt-1 during ErbB-2-induced mammary tumorigenesis may have opposing effects on tumor growth and metastatic progression...
  67. ncbi request reprint Somatic inactivation of E-cadherin and p53 in mice leads to metastatic lobular mammary carcinoma through induction of anoikis resistance and angiogenesis
    Patrick W B Derksen
    Division of Molecular Biology, Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands
    Cancer Cell 10:437-49. 2006
    ..Moreover, loss of E-cadherin induced anoikis resistance and facilitated angiogenesis, thus promoting metastatic disease. Our results suggest that loss of E-cadherin contributes to both mammary tumor initiation and metastasis...
  68. pmc Mammary tumorigenesis following transgenic expression of a dominant negative CHK2 mutant
    Eunice L Kwak
    Massachusetts General Hospital Cancer Center and Harvard Medical School, Charlestown, Massachusetts 02129, USA
    Cancer Res 66:1923-8. 2006
    ..The increased rate of tumor formation in MMTV-CHK2-D347A mice, compared with the relatively low incidence in chk2-null mice, provides a model to study modifiers of CHK2-dependent transformation...
  69. pmc Differential sensitivity of mouse epithelial tissues to the polyomavirus middle T oncogene
    Grace Cecena
    OncoDevelopmental Biology Program, Cancer Research Center, The Burnham Institute, La Jolla, CA 92037, USA
    Am J Pathol 168:310-20. 2006
    ..The variety of responses of different epithelia to PyMT demonstrates the importance of the differentiated state in interpreting oncogenic signals...
  70. ncbi request reprint Selective evolution of stromal mesenchyme with p53 loss in response to epithelial tumorigenesis
    Reginald Hill
    Curriculum in Genetics and Molecular Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Cell 123:1001-11. 2005
    ..This interaction imposes strong selective pressure yielding a highly proliferative mesenchyme that has undergone p53 loss...
  71. ncbi request reprint Heterogeneous tumor evolution initiated by loss of pRb function in a preclinical prostate cancer model
    Reginald Hill
    Curriculum in Genetics and Molecular Biology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    Cancer Res 65:10243-54. 2005
    ..Given that this analysis models the apparent timing of highly penetrant events in human prostate cancer, observed effects may recapitulate the natural evolution of prostate cancer development...
  72. ncbi request reprint Oncogenic signaling pathways activated in DMBA-induced mouse mammary tumors
    Nicolas Currier
    Boston University School of Medicine, Department of Medicine, Boston, MA, USA
    Toxicol Pathol 33:726-37. 2005
    ..These data suggest that environmental carcinogens can produce long-lasting alterations in growth and anti-apoptotic pathways, leading to mammary tumorigenesis...
  73. ncbi request reprint The transcriptional repressor Snail promotes mammary tumor recurrence
    Susan E Moody
    Department of Cancer Biology, Abramson Family Cancer Research Institute, University of Pennsylvania School of Medicine, Philadelphia, 19104, USA
    Cancer Cell 8:197-209. 2005
    ..In aggregate, our observations strongly implicate Snail in the process of breast cancer recurrence...
  74. pmc A critical role for p27kip1 gene dosage in a mouse model of prostate carcinogenesis
    Hui Gao
    Center for Advanced Biotechnology and Medicine, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, Piscataway, NJ 08854, USA
    Proc Natl Acad Sci U S A 101:17204-9. 2004
    ..Our findings suggest that p27(kip1) possesses dosage-sensitive positive as well as negative modulatory roles in prostate cancer progression...
  75. pmc Developmental context determines latency of MYC-induced tumorigenesis
    Shelly Beer
    Division of Oncology, Department of Medicine, Stanford University, Stanford, California, USA
    PLoS Biol 2:e332. 2004
    ..Adult somatic cells have evolved mechanisms to prevent individual oncogenes from initiating cellular growth, DNA replication, and mitotic cellular division alone, thereby preventing any single genetic event from inducing tumorigenesis...
  76. ncbi request reprint Mice expressing SV40 T antigen directed by the intestinal trefoil factor promoter develop tumors resembling human small cell carcinoma of the colon
    James R Gum
    Department of Veterans Affairs Medical Center, 4150 Clement Street, San Francisco, CA 94121, USA
    Mol Cancer Res 2:504-13. 2004
    ..ITFTag tumors closely resemble human small cell carcinomas of the colon, suggesting the possibility that these tumors might be derived from the enteroendocrine cell lineage as well...
  77. ncbi request reprint Deregulation of Stat5 expression and activation causes mammary tumors in transgenic mice
    Elena Iavnilovitch
    Institute of Animal Science, Agricultural Research Organization, Volcani Center, Bet Dagan, Israel
    Int J Cancer 112:607-19. 2004
    ..The transactivation function of Stat5 is involved in the determination of tumors with a more differentiated phenotype...
  78. ncbi request reprint Molecular characterization of the transition to malignancy in a genetically engineered mouse-based model of ductal carcinoma in situ
    Ruria Namba
    Department of Pathology and Laboratory Medicine, School of Medicine, University of California Davis, Sacramento, California 95817, USA
    Mol Cancer Res 2:453-63. 2004
    ..With consistent tumor latency and molecular profiles, this model provides an experimental platform that can be used to assess functional genomics and molecular pharmacology and to test promising chemoprevention strategies...
  79. ncbi request reprint Polyomavirus middle T-induced mammary intraepithelial neoplasia outgrowths: single origin, divergent evolution, and multiple outcomes
    Jeannie E Maglione
    Department of Medicine, UCSD Cancer Center, School of Medicine, University of California San Diego, La Jolla, CA, USA
    Mol Cancer Ther 3:941-53. 2004
    ..These lines provide an opportunity to study the full range of events occurring secondary to PyV-mT expression in the mammary gland...
  80. ncbi request reprint Nkx3.1 mutant mice recapitulate early stages of prostate carcinogenesis
    Minjung J Kim
    Department of Neuroscience, Center for Advanced Biotechnology and Medicine, 679 Hoes Lane, Piscataway, NJ 08854, USA
    Cancer Res 62:2999-3004. 2002
    ..1 mutant mice accurately model early stages of prostate carcinogenesis. More generally, our tissue recombination assay provides an empirical test to examine the relationship of PIN to prostate carcinoma...