Joseph A Carcillo

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. pmc Rationale and design of the pediatric critical illness stress-induced immune suppression (CRISIS) prevention trial
    Joseph Carcillo
    Children s Hospital of Pittsburgh, PA 15261, USA
    JPEN J Parenter Enteral Nutr 33:368-74. 2009
  2. pmc Hyperferritinemia in the critically ill child with secondary hemophagocytic lymphohistiocytosis/sepsis/multiple organ dysfunction syndrome/macrophage activation syndrome: what is the treatment?
    Demet Demirkol
    Department of Pediatric Intensive Care, Bezmialem Vakif University, Faculty of Medicine, Vatan Caddesi, Istanbul, 34093, Turkey
    Crit Care 16:R52. 2012
  3. pmc Donation after cardiocirculatory death: a call for a moratorium pending full public disclosure and fully informed consent
    Ari R Joffe
    Department of Pediatrics, University of Alberta, Stollery Children s Hospital, Edmonton Clinic Health Academy 11405 87 Avenue, Edmonton, Alberta, T6G 1C9, Canada
    Philos Ethics Humanit Med 6:17. 2011
  4. pmc The randomized comparative pediatric critical illness stress-induced immune suppression (CRISIS) prevention trial
    Joseph A Carcillo
    Children s Hospital of Pittsburgh of UPMC, Pittsburgh, PA, USA
    Pediatr Crit Care Med 13:165-73. 2012
  5. pmc Bench-to-bedside review: thrombocytopenia-associated multiple organ failure--a newly appreciated syndrome in the critically ill
    Trung C Nguyen
    Texas Children s Hospital, 6621 Fannin St MC2 3450, Houston, TX 770330, USA
    Crit Care 10:235. 2006
  6. ncbi request reprint Pediatric septic shock and multiple organ failure
    Joseph A Carcillo
    Division of Critical Care Medicine, Children s Hospital of Pittsburgh, 3705 5th Avenue, Pittsburgh, PA 15123, USA
    Crit Care Clin 19:413-40, viii. 2003
  7. doi request reprint Multiple organ system extracorporeal support in critically ill children
    Joseph A Carcillo
    Pediatric Critical Care, Children s Hospital of Pittsburgh, 3705 Fifth Ave, Pittsburgh, PA 15213, USA
    Pediatr Clin North Am 55:617-46, x-xi. 2008
  8. ncbi request reprint Cytochrome P450 mediated-drug metabolism is reduced in children with sepsis-induced multiple organ failure
    Joseph A Carcillo
    Division of Critical Care Medicine, Children s Hospital of Pittsburgh, 3705 5th Ave, Pittsburgh, PA 15123, USA
    Intensive Care Med 29:980-4. 2003
  9. pmc Intensive plasma exchange increases a disintegrin and metalloprotease with thrombospondin motifs-13 activity and reverses organ dysfunction in children with thrombocytopenia-associated multiple organ failure
    Trung C Nguyen
    Section of Critical Care, Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA
    Crit Care Med 36:2878-87. 2008
  10. ncbi request reprint Procalcitonin is persistently increased among children with poor outcome from bacterial sepsis
    Yong Y Han
    Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Pediatr Crit Care Med 4:21-5. 2003

Research Grants

  1. Metoclopramide prevents PICU nosocomial infection
    Joseph Carcillo; Fiscal Year: 2007

Collaborators

Detail Information

Publications49

  1. pmc Rationale and design of the pediatric critical illness stress-induced immune suppression (CRISIS) prevention trial
    Joseph Carcillo
    Children s Hospital of Pittsburgh, PA 15261, USA
    JPEN J Parenter Enteral Nutr 33:368-74. 2009
    ..The authors present the design and analytic plan for the CRISIS prevention trial...
  2. pmc Hyperferritinemia in the critically ill child with secondary hemophagocytic lymphohistiocytosis/sepsis/multiple organ dysfunction syndrome/macrophage activation syndrome: what is the treatment?
    Demet Demirkol
    Department of Pediatric Intensive Care, Bezmialem Vakif University, Faculty of Medicine, Vatan Caddesi, Istanbul, 34093, Turkey
    Crit Care 16:R52. 2012
    ..We hypothesized that patients with hyperferritinemia associated secondary HLH/sepsis/MODS/MAS can be successfully treated with a less immunosuppressant approach than is recommended for primary HLH...
  3. pmc Donation after cardiocirculatory death: a call for a moratorium pending full public disclosure and fully informed consent
    Ari R Joffe
    Department of Pediatrics, University of Alberta, Stollery Children s Hospital, Edmonton Clinic Health Academy 11405 87 Avenue, Edmonton, Alberta, T6G 1C9, Canada
    Philos Ethics Humanit Med 6:17. 2011
    ..These are tall orders, and require open public debate. Until this debate occurs, we call for a moratorium on the practice of DCD...
  4. pmc The randomized comparative pediatric critical illness stress-induced immune suppression (CRISIS) prevention trial
    Joseph A Carcillo
    Children s Hospital of Pittsburgh of UPMC, Pittsburgh, PA, USA
    Pediatr Crit Care Med 13:165-73. 2012
    ..We evaluated whether daily nutriceutical supplementation with zinc, selenium, glutamine, and metoclopramide, compared to whey protein, would reduce the occurrence of nosocomial infection/sepsis in this at-risk population...
  5. pmc Bench-to-bedside review: thrombocytopenia-associated multiple organ failure--a newly appreciated syndrome in the critically ill
    Trung C Nguyen
    Texas Children s Hospital, 6621 Fannin St MC2 3450, Houston, TX 770330, USA
    Crit Care 10:235. 2006
    ....
  6. ncbi request reprint Pediatric septic shock and multiple organ failure
    Joseph A Carcillo
    Division of Critical Care Medicine, Children s Hospital of Pittsburgh, 3705 5th Avenue, Pittsburgh, PA 15123, USA
    Crit Care Clin 19:413-40, viii. 2003
    ..This article discusses these advances, updating the 1997 article on septic shock written by the author and by Dr. Robert E. Cunnion and following the format of the 1997 article...
  7. doi request reprint Multiple organ system extracorporeal support in critically ill children
    Joseph A Carcillo
    Pediatric Critical Care, Children s Hospital of Pittsburgh, 3705 Fifth Ave, Pittsburgh, PA 15213, USA
    Pediatr Clin North Am 55:617-46, x-xi. 2008
    ..These therapies represent a significant advance in pediatric critical care medicine. This article provides a framework for this multidisciplinary team approach for implementing these therapies...
  8. ncbi request reprint Cytochrome P450 mediated-drug metabolism is reduced in children with sepsis-induced multiple organ failure
    Joseph A Carcillo
    Division of Critical Care Medicine, Children s Hospital of Pittsburgh, 3705 5th Ave, Pittsburgh, PA 15123, USA
    Intensive Care Med 29:980-4. 2003
    ..Because interleukin-6 and nitric oxide production increases in children with sepsis-induced multiple organ failure, we hypothesized impaired CYP 450 mediated drug metabolism in this population...
  9. pmc Intensive plasma exchange increases a disintegrin and metalloprotease with thrombospondin motifs-13 activity and reverses organ dysfunction in children with thrombocytopenia-associated multiple organ failure
    Trung C Nguyen
    Section of Critical Care, Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA
    Crit Care Med 36:2878-87. 2008
    ....
  10. ncbi request reprint Procalcitonin is persistently increased among children with poor outcome from bacterial sepsis
    Yong Y Han
    Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Pediatr Crit Care Med 4:21-5. 2003
    ..To examine the relationships between procalcitonin, bacterial infection, sepsis-induced multiple organ failure, and mortality rate in children...
  11. ncbi request reprint Early reversal of pediatric-neonatal septic shock by community physicians is associated with improved outcome
    Yong Y Han
    Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Pediatrics 112:793-9. 2003
    ..The objective of this study was to determine whether early septic shock reversal and use of resuscitation practice consistent with the new ACCM-PALS Guidelines by community physicians is associated with improved outcome...
  12. doi request reprint Mortality and functional morbidity after use of PALS/APLS by community physicians
    Joseph A Carcillo
    Department of Pediatrics and Critical Care Medicine, University of Pittsburgh School of Medicine, Children s Hospitalof Pittsburgh, Pittsburgh, Pennsylvania, USA
    Pediatrics 124:500-8. 2009
    ....
  13. pmc Advances in monitoring and management of shock
    Haifa Mtaweh
    Department of Critical Care Medicine, Children s Hospital of Pittsburgh, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    Pediatr Clin North Am 60:641-54. 2013
    ..Other emerging treatments for shock (ie, temperature control, extracorporeal membrane oxygenation/ventricular assist devices) are also discussed...
  14. pmc The role of plasmapheresis in critical illness
    Trung C Nguyen
    Section of Critical Care Medicine, Department of Pediatrics, Baylor College of Medicine Texas Children s Hospital, Houston, TX 77030, USA
    Crit Care Clin 28:453-68, vii. 2012
    ....
  15. ncbi request reprint Clinical practice parameters for hemodynamic support of pediatric and neonatal patients in septic shock
    Joseph A Carcillo
    Children s Hospital of Pittsburgh, Division of Critical Care Medicine, 15213, USA
    Crit Care Med 30:1365-78. 2002
    ..The Institute of Medicine has called for the development of clinical guidelines and practice parameters to develop "best practice" and potentially improve patient outcome...
  16. ncbi request reprint Unexpected increased mortality after implementation of a commercially sold computerized physician order entry system
    Yong Y Han
    Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Pediatrics 116:1506-12. 2005
    ..We sought to test the hypothesis that CPOE implementation results in reduced mortality among children who are transported for specialized care...
  17. doi request reprint Biomarker response to drotrecogin alfa (activated) in children with severe sepsis: results from the RESOLVE clinical trial*
    Heidi J Dalton
    Division of Critical Care Medicine, Phoenix Children s Hospital, Phoenix, AZ, USA
    Pediatr Crit Care Med 13:639-45. 2012
    ..This report describes biomarker profiles in early severe sepsis and the pharmacodynamic assessment of drotrecogin alfa (activated) in RESOLVE...
  18. pmc Admission angiopoietin levels in children with septic shock
    John S Giuliano
    Division of Critical Care Medicine, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
    Shock 28:650-654. 2007
    ..Given the contrasting effects of angpt-2 and angpt-1 on the vascular endothelium, these two factors may play an important role in the pathophysiology of septic shock in children, and further studies are warranted...
  19. ncbi request reprint Scope and epidemiology of pediatric sepsis
    R Scott Watson
    Department of Critical Care Medicine RSW, JAC, Center for Research on Health Care, and the Clinical Research, Investigation, and Systems Modeling in Acute Illness Laboratory, University of Pittsburgh, Pittsburgh, PA, USA
    Pediatr Crit Care Med 6:S3-5. 2005
    ..To summarize the scope and epidemiology of pediatric sepsis...
  20. ncbi request reprint Prolonged lymphopenia, lymphoid depletion, and hypoprolactinemia in children with nosocomial sepsis and multiple organ failure
    Kate A Felmet
    Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    J Immunol 174:3765-72. 2005
    ..Prolonged hypoprolactinemia is a previously unrecognized risk factor for this syndrome...
  21. ncbi request reprint What's new in pediatric intensive care
    Joseph A Carcillo
    Children s Hospital of Pittsburgh, Anesthesiology, Pittsburgh, PA, USA
    Crit Care Med 34:S183-90. 2006
    ..To provide an update on new developments in the field of pediatric intensive care...
  22. ncbi request reprint Plasma concentrations of defensins and lactoferrin in children with severe sepsis
    Neal J Thomas
    Department of Anesthesiology and Critical Care Medicine, University of Pittsburgh School of Medicine and Children s Hospital of Pittsburgh, Pittsburgh, PA 15213, USA
    Pediatr Infect Dis J 21:34-8. 2002
    ....
  23. doi request reprint Outcomes of previously healthy pediatric patients with fulminant sepsis-induced multisystem organ failure receiving therapeutic plasma exchange
    Lirong Qu
    Institute for Transfusion Medicine, Pittsburgh, Pennsylvania, USA
    J Clin Apher 26:208-13. 2011
    ..Therapeutic plasma exchange (TPE) has been reported to be beneficial in sepsis-induced MSOF. We evaluated the outcomes of previously healthy children with fulminant sepsis-induced MSOF receiving TPE...
  24. pmc Sepsis in the pediatric cardiac intensive care unit
    Derek S Wheeler
    Division of Critical Care Medicine, Cincinnati Children s Hospital Medical Center, Cincinnati, OH, USA
    World J Pediatr Congenit Heart Surg 2:393-9. 2011
    ..Herein, we review the epidemiology, pathobiology, and management of sepsis in the pediatric cardiac intensive care unit. ..
  25. doi request reprint Brain injuries and neurological system failure are the most common proximate causes of death in children admitted to a pediatric intensive care unit
    Alicia K Au
    Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Pediatr Crit Care Med 12:566-71. 2011
    ..We hypothesized that neurologic injuries are an important cause of death in children...
  26. ncbi request reprint The epidemiology of severe sepsis in children in the United States
    R Scott Watson
    Department of Critical Care Medicine, Center for Research on Health Care, and the CRISMA Clinical Research, Investigation, and Systems Modeling of Acute Illness Laboratory, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    Am J Respir Crit Care Med 167:695-701. 2003
    ..97 billion US dollars nationally. Severe sepsis is a significant health problem in children and is associated with the use of extensive healthcare resources. Infants are at highest risk, especially those with a low birth weight...
  27. ncbi request reprint Reducing the global burden of sepsis in infants and children: a clinical practice research agenda
    Joseph A Carcillo
    Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Pediatr Crit Care Med 6:S157-64. 2005
    ..Sepsis remains a predominant cause of mortality and morbidity in children in the developing and industrialized world. This review discusses a clinical practice research agenda to reduce this global burden...
  28. ncbi request reprint Coordinated intrahepatic and extrahepatic regulation of cytochrome p4502D6 in healthy subjects and in patients after liver transplantation
    Joseph A Carcillo
    Department of Pediatrics, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Clin Pharmacol Ther 73:456-67. 2003
    ....
  29. ncbi request reprint Intra-mitochondrial poly(ADP-ribosylation) contributes to NAD+ depletion and cell death induced by oxidative stress
    Lina Du
    Department of Critical Care Medicine, University of Pittsburgh, Safar Center for Resuscitation Research, Pittsburgh, Pennsylvania 15260, USA
    J Biol Chem 278:18426-33. 2003
    ..These data implicate intra-mitochondrial poly(ADP-ribosylation) as an important therapeutic target for central nervous system and other diseases associated with oxidative stress and energy failure...
  30. pmc What is the rationale for hydrocortisone treatment in children with infection-related adrenal insufficiency and septic shock?
    Rajesh Aneja
    Department of Critical Care Medicine and Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Arch Dis Child 92:165-9. 2007
    ....
  31. pmc Linezolid and lactic acidosis: a role for lactate monitoring with long-term linezolid use in children
    Erik Su
    Department of Pediatric Critical Care Medicine, Division of Infectious Disease, Children s Hospital of Pittsburgh of UPMC, Pittsburgh, PA, USA
    Pediatr Infect Dis J 30:804-6. 2011
    ..Three cases of linezolid-associated lactic acidosis in children are reported to reinforce the need for pediatric caregivers to be vigilant of this potential side effect...
  32. doi request reprint Aerosol delivery through nasal cannulas: an in vitro study
    Abhiram R Bhashyam
    Pulmonary, Allergy, and Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA, USA
    J Aerosol Med Pulm Drug Deliv 21:181-8. 2008
    ..2-3.5%). This study demonstrates that aerosols can be efficiently delivered through a humidified high-flow nasal cannula system. Further study is required to determine if this route is viable for pulmonary delivery...
  33. ncbi request reprint Type IV phosphodiesterase inhibition improves cardiac contractility in endotoxemic rats
    Neal J Thomas
    Department of Critical Care Medicine, Center for Clinical Pharmacology, University of Pittsburgh School of Medicine, Pittsburgh, PA 17033, USA
    Eur J Pharmacol 465:133-9. 2003
    ..Clinical studies of type IV phosphodiesterase inhibitors in critically ill patients are indicated...
  34. ncbi request reprint Liposomal NAD(+) prevents diminished O(2) consumption by immunostimulated Caco-2 cells
    Abrar U Khan
    Department of Critical Care Medicine, University of Pittsburgh Medical School, Pittsburgh, Pennsylvania 15261, USA
    Am J Physiol Lung Cell Mol Physiol 282:L1082-91. 2002
    ..These data are consistent with the view that enterocytes exposed to proinflammatory cytokines consume less O(2) due to NAD(+)/NADH depletion secondary to activation of PARP by ONOO(-) or other oxidants...
  35. ncbi request reprint Mannose-binding lectin deficiency provides a genetic basis for the use of SIRS/sepsis definitions in critically ill patients
    Joseph A Carcillo
    Intensive Care Med 30:1263-5. 2004
  36. ncbi request reprint The tissue factor and plasminogen activator inhibitor type-1 response in pediatric sepsis-induced multiple organ failure
    Jerril Green
    Department of Anesthesiology and Critical Care Medicine and Pediatrics, University of Pittsburgh School of Medicine, Pennsylvania, USA
    Thromb Haemost 87:218-23. 2002
    ..Because cytokine release is increased in children with sepsis-induced multiple organ failure (MOF), we hypothesized a cytokine associated increase in circulating TF and PAI-1 antigen release, and systemic activity in these patients...
  37. ncbi request reprint Pediatric considerations
    Margaret M Parker
    Department of Pediatrics, Stony Brook University, Stony Brook, NY, USA
    Crit Care Med 32:S591-4. 2004
    ....
  38. ncbi request reprint Absolute and relative adrenal insufficiency in children with septic shock
    Cristiane F Pizarro
    Pediatric Intensive Care Unit, Department of Pediatrics, Instituto da Criança Pedro de Alcântra, Faculdade de Medicina Universidade de São Paulo, São Paulo SP 01238 000, Brazil
    Crit Care Med 33:855-9. 2005
    ..We evaluated the relationship of absolute and relative adrenal insufficiency to catecholamine-resistant septic shock in children...
  39. ncbi request reprint Sepsis associated with immunosuppressive medications: an evidence-based review
    Juan C Gea-Banacloche
    National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
    Crit Care Med 32:S578-90. 2004
    ....
  40. ncbi request reprint Searching for the etiology of systemic inflammatory response syndrome: is SIRS occult endotoxemia?
    Joseph A Carcillo
    Intensive Care Med 32:181-4. 2006
  41. pmc Pro/con clinical debate: do colloids have advantages over crystalloids in paediatric sepsis?
    Puran Khandelwal
    Department of Critical Care Medicine, The Hospital for Sick Children, Toronto, Ontario, Canada
    Crit Care 6:286-8. 2002
  42. ncbi request reprint Is there a role for plasmapheresis/plasma exchange therapy in septic shock, MODS, and thrombocytopenia-associated multiple organ failure? We still do not know--but perhaps we are closer
    Joseph A Carcillo
    Intensive Care Med 28:1373-5. 2002
  43. ncbi request reprint Does arginine become a "near" essential amino acid during sepsis?
    Joseph A Carcillo
    Crit Care Med 31:657-9. 2003
  44. ncbi request reprint Fluid resuscitation of hypovolemic shock: acute medicine's great triumph for children
    Joseph A Carcillo
    Intensive Care Med 32:958-61. 2006
  45. ncbi request reprint Understanding the role of von Willebrand factor and its cleaving protease ADAM TS13 in the pathophysiology of critical illness
    Trung C Nguyen
    Pediatr Crit Care Med 8:187-9. 2007
  46. ncbi request reprint Extracellular hsp70 levels in children with septic shock
    Derek S Wheeler
    Department of Pediatrics, University of Cincinnati College of Medicine and Children s Hospital Research Foundation, Cincinnati, OH, USA
    Pediatr Crit Care Med 6:308-11. 2005
    ..To determine whether hsp70 is elevated in the plasma of children with septic shock...
  47. ncbi request reprint Pediatric critical care medicine: planning for our research future
    Carol E Nicholson
    National Institute of Child Health and Human Development, 6100 Executive Boulevard, Room 2A03 MSC 7510, Bethesda, MD 20892, USA
    Pediatr Crit Care Med 4:196-202. 2003
    ..To introduce to the pediatric critical care medicine community a new program in pediatric critical care medicine at the National Institutes of Health...
  48. ncbi request reprint Procalcitonin and C-reactive protein kinetics in postoperative pediatric cardiac surgical patients
    Ronaldo Arkader
    Department of Pediatrics, School of Medicine, University of Sao Paulo, Sao Paulo, Brazil
    J Cardiothorac Vasc Anesth 18:160-5. 2004
    ..To determine the kinetics of procalcitonin (PCT) and C-reactive protein (CRP) concentration after pediatric cardiac surgery with cardiopulmonary bypass...
  49. ncbi request reprint Definitions of pediatric septic shock
    Bradley A Kuch
    Pediatr Crit Care Med 6:501; author reply 501. 2005

Research Grants3

  1. Metoclopramide prevents PICU nosocomial infection
    Joseph Carcillo; Fiscal Year: 2007
    ..The long term goal of the project is to develop innovative strategies to improve immune function and reduce nosocomial infection and sepsis in critically ill children. ..