Research Topics
| M CarboneSummaryAffiliation: University of Hawaii Country: USA Publications
Research Grants
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Detail Information
Publications
Blocking of ERK1 and ERK2 sensitizes human mesothelioma cells to doxorubicinArti Shukla
Department of Pathology, University of Vermont College of Medicine, 89 Beaumont Avenue, Burlington, VT 05405, USA
Mol Cancer 9:314. 2010..Using the MEK1/2 inhibitor, U0126 and stably transfected shERK1 and shERK2 MM cell lines, we show that inhibition of both ERK1 and 2 sensitizes MM cells to Dox...
The pathogenesis of mesotheliomaMichele Carbone
Thoracic Oncology Program, Cancer Research Center of Hawaii, University of Hawaii, Honolulu, Hawaii 96813, USA
Semin Diagn Pathol 23:56-60. 2006..Moreover, these data provide a rationale for the observation that only a fraction of heavily exposed asbestos workers developed mesothelioma, and novel targets for prevention and therapy...- A mesothelioma epidemic in Cappadocia: scientific developments and unexpected social outcomesMichele Carbone
Cancer Research Center of Hawaii, Thoracic Oncology Program, Honolulu, Hawaii 96816, USA
Nat Rev Cancer 7:147-54. 2007.... - Eighth international mesothelioma interest groupM Carbone
Thoracic Oncology, Cancer Research Center of Hawaii, University of Hawaii, Honolulu, HI, USA
Oncogene 26:6959-67. 2007..The result is a comprehensive review of the research field of asbestos carcinogenesis and mesothelioma, and of the progress that has been made in recent years in both basic and clinical sciences... - Malignant mesothelioma: facts, myths, and hypothesesMichele Carbone
University of Hawaii Cancer Center, University of Hawaii, Honolulu, Hawaii 96813, USA
J Cell Physiol 227:44-58. 2012..Genetic predisposition, radiation exposure and viral infection are co-factors that can alone or together with asbestos and erionite cause MM. J. Cell. Physiol. 227: 44-58, 2012. © 2011 Wiley Periodicals, Inc... - A novel mechanism of late gene silencing drives SV40 transformation of human mesothelial cellsMichele Carbone
Thoracic Oncology Program, Cancer Center of Hawaii and Department of Pathology, University of Hawaii Medical School, Honolulu, Hawaii 96813, USA
Cancer Res 68:9488-96. 2008..Our results reveal a novel biological mechanism responsible for the suppression of late viral gene products, an important step in viral carcinogenesis in humans... - Mesothelioma epidemiology, carcinogenesis, and pathogenesisHaining Yang
Cancer Research Center of Hawaii, University of Hawaii, Honolulu, HI 96813, USA
Curr Treat Options Oncol 9:147-57. 2008..It is hoped that the identification of this putative mesothelioma gene will lead to novel mechanistically driven preventive and therapeutic approaches... - Crocidolite asbestos and SV40 are cocarcinogens in human mesothelial cells and in causing mesothelioma in hamstersBarbara Kroczynska
Thoracic Oncology Program, Cardinal Bernardin Cancer Center, Loyola University Chicago, Maywood, IL 60153, USA
Proc Natl Acad Sci U S A 103:14128-33. 2006..Our results indicate that mineral fibers and viruses can be cocarcinogens and suggest that lower amounts of asbestos may be sufficient to cause MM in individuals infected with SV40... - Programmed necrosis induced by asbestos in human mesothelial cells causes high-mobility group box 1 protein release and resultant inflammationHaining Yang
Cancer Research Center of Hawaii, John A Burns School of Medicine, University of Hawaii, Honolulu, HI 96813, USA
Proc Natl Acad Sci U S A 107:12611-6. 2010..Chemopreventive approaches aimed at inhibiting the chronic inflammatory response, and especially blocking HMGB1, may decrease the risk of malignant mesothelioma among asbestos-exposed cohorts... 
The relationship between simian virus 40 and mesotheliomaZeyana Rivera
Cancer Research Center of Hawaii and Department of Pathology, University of Hawaii, Honolulu, Hawaii, USA
Curr Opin Pulm Med 14:316-21. 2008..Simian virus 40 is present in some human malignant mesotheliomas. The evidence in favor and against a pathogenic role of simian virus 40 in malignant mesothelioma is discussed in this review...- TNF-alpha inhibits asbestos-induced cytotoxicity via a NF-kappaB-dependent pathway, a possible mechanism for asbestos-induced oncogenesisHaining Yang
Thoracic Oncology Program, Cardinal Bernardin Cancer Center, Loyola University Chicago, Maywood, IL 60153, USA
Proc Natl Acad Sci U S A 103:10397-402. 2006.... - Identification of intelectin overexpression in malignant pleural mesothelioma by serial analysis of gene expression (SAGE)Anil Wali
Thoracic Oncology Program, Karmanos Cancer Institute, and John D Dingell VA Medical Center, Wayne State University, 3990 John R, Suite 2102, Detroit, MI 48201, USA
Lung Cancer 48:19-29. 2005..Intelectin overexpression in mesothelioma could have potential screening, and therapeutic implications... - MesotheliomaMichele Carbone
Thoracic Oncology Program, Cancer Research Center of Hawai i, USA
Hawaii Med J 66:48-50. 2007..The public health and litigation issues, together with the economics surrounding mesothelioma research and therapy are also discussed... - Chemotherapy of malignant pleural mesotheliomaPietro Bertino
Cancer Research Center of Hawaii and Department of Pathology, University of Hawaii, 651 Ilalo Street, BSB Room 231, Honolulu, HI 96813, USA
Expert Opin Pharmacother 10:99-107. 2009..Although the outcome for patients remains poor, there has been definite progress in the systemic treatment of this disease within the past 5 years... - Gene expression profiles predict survival and progression of pleural mesotheliomaHarvey I Pass
Thoracic Oncology, Karmanos Cancer Institute, Wayne State University, Detroit, MI 48201, USA
Clin Cancer Res 10:849-59. 2004..We hypothesized that gene expression profiles could predict time to progression and survival in surgically cytoreduced pleural mesothelioma of all stages... - Spindle cell tumors of the pleura: differential diagnosisMonica Rdzanek
Thoracic Oncology Program, Cardinal Bernardin Cancer Center, Loyola University, Maywood, Illinois, USA
Semin Diagn Pathol 23:44-55. 2006.... - Some oral poliovirus vaccines were contaminated with infectious SV40 after 1961Rochelle Cutrone
Thoracic Oncology Program, Cardinal Bernardin Cancer Center, Loyola University, Chicago, Illinois, USA
Cancer Res 65:10273-9. 2005..Moreover, our results indicate possible geographic differences in SV40 exposure and offer a possible explanation for the different percentage of SV40-positive tumors detected in some laboratories... - The role of environmental carcinogens, viruses and genetic predisposition in the pathogenesis of mesotheliomaAmy Powers
Loyola University Chicago, Cardinal Bernardin Cancer Center, Maywood, Illinois 60153, USA
Cancer Biol Ther 1:348-53. 2002..The challenge for future research is to establish how these apparently very different factors interact to cause mesotheliomas... - Cellular and molecular parameters of mesotheliomaMaria E Ramos-Nino
Department of Pathology, University of Vermont College of Medicine, Burlington, Vermont 05405, USA
J Cell Biochem 98:723-34. 2006..These mechanistic approaches offer new hope for early detection and treatment of these devastating tumors... - Genetic predisposition to fiber carcinogenesis causes a mesothelioma epidemic in TurkeyA Umran Dogan
Department of Geological Engineering, Ankara University, Ankara, Turkey
Cancer Res 66:5063-8. 2006..This is the first time that genetics is shown to influence mineral fiber carcinogenesis... - Malignant pleural mesotheliomaHarvey I Pass
Department of Surgery, Wayne State University Medical School, Detroit, Michigan, USA
Curr Probl Cancer 28:93-174. 2004 - Asbestos exposure, pleural mesothelioma, and serum osteopontin levelsHarvey I Pass
Department of Surgery, Wayne State University, Karmanos Cancer Institute, John A Dingell Veterans Hospital, Detroit, Mich, USA
N Engl J Med 353:1564-73. 2005.... - Lung diseases due to environmental exposures to erionite and asbestos in TurkeySalih Emri
Department of Chest Diseases, Hacettepe Medical Faculty, Hacettepe University Hospital, Sihhiye, 06100 Ankara, Turkey
Toxicol Lett 127:251-7. 2002..An additional recent genetic-epidemiological study showed that there are some families, which are genetically predisposed to mesothelioma... - The pathogenesis of mesotheliomaMichele Carbone
Cancer Immunology Program, Cardinal Bernardin Cancer Center, Department of Pathology, Loyola University Chicago, USA
Semin Oncol 29:2-17. 2002..Mesothelioma appears to have a complex etiology in which environmental carcinogens (asbestos and erionite), ionizing radiation, viruses, and genetic factors act alone or in concert to cause malignancy... - Pathogenesis of malignant mesotheliomaMichele Carbone
Cancer Immunology Program, Department of Pathology, Cardinal Bernardin Cancer Center, Loyola University Chicago, Maywood, IL 60153, USA
Clin Lung Cancer 5:S46-50. 2004..Currently available therapies for MM prolong survival by a few months at most. An SV40 vaccine is being developed for human use and it is hoped that it may reduce the incidence of MM in asbestos workers... - HGF mediates cell proliferation of human mesothelioma cells through a PI3K/MEK5/Fra-1 pathwayMaria E Ramos-Nino
University of Vermont College of Medicine, Department of Pathology, 89 Beaumont Avenue HSRF 216, Burlington, VT 05405, USA
Am J Respir Cell Mol Biol 38:209-17. 2008..Data suggest that HGF-induced effects in some MM cells are mediated via activation of a novel PI3K/ERK5/Fra-1 feedback pathway that might explain tumor-specific effects of c-Met inhibitors on MM and other tumors... - Extrapleural pneumonectomy versus pleurectomy/decortication in the surgical management of malignant pleural mesothelioma: results in 663 patientsRaja M Flores
Thoracic Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
J Thorac Cardiovasc Surg 135:620-6, 626.e1-3. 2008..We performed a multi-institutional study to increase statistical power to detect significant differences in outcome between extrapleural pneumonectomy and pleurectomy/decortication... - Ranpirnase as a potential antitumor ribonuclease treatment for mesothelioma and other malignanciesAmanda K Beck
New York University School of Medicine, 530 First Ave, Suite 9V, New York, NY 10016, USA
Future Oncol 4:341-9. 2008..Owing to its selective destruction of malignant cells and favorable toxicology profile, ranpirnase is a promising antitumor agent with ideal attributes that are generally lacking in conventional cytotoxic drugs... - Soluble mesothelin-related peptide level elevation in mesothelioma serum and pleural effusionsHarvey I Pass
Department of Cardiothoracic Surgery, Division of Thoracic Surgery, New York University School of Medicine, New York, New York 10016, USA
Ann Thorac Surg 85:265-72; discussion 272. 2008..Soluble mesothelin-related peptide (SMRP) is a potential marker for malignant pleural mesothelioma (MPM), which may be useful for screening high-risk asbestos-exposed individuals... - A cytokeratin- and calretinin-negative staining sarcomatoid malignant mesotheliomaMichael G Hurtuk
Cardinal Bernadin Cancer Center, Cancer Immunology Program, Department of Pathology, Loyola University Chicago, Maywood, IL 60153, USA
Anticancer Res 24:3097-102. 2004.... - SV40 and human tumours: myth, association or causality?Adi F Gazdar
Hamon Center for Therapeutic Oncology Research and Department of Pathology, University of Texas Southwestern Medical Centre, Dallas, Texas 75390, USA
Nat Rev Cancer 2:957-64. 2002..How did a simian virus infect humans and is the virus a passenger in tumours or is it important in their pathogenesis?.. - Progressive aberrant methylation of the RASSF1A gene in simian virus 40 infected human mesothelial cellsShinichi Toyooka
Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, Texas, TX 75390, USA
Oncogene 21:4340-4. 2002..These data, together with our previous findings, support a causal relationship between SV40 infection, progressive RASSF1A methylation and its silencing, and the pathogenesis of mesothelioma... - SV40 infection induces telomerase activity in human mesothelial cellsRudy Foddis
Cancer Immunology Program, Department of Pathology, Cardinal Bernardin Cancer Center, Loyola University Chicago, Maywood, Illinois, IL 60153, USA
Oncogene 21:1434-42. 2002..Induction of telomerase activity by SV40 may be related to the very high rate of mesothelial cell immortalization that is characteristically associated with SV40 infection of mesothelial cells... - Notch-1 induction, a novel activity of SV40 required for growth of SV40-transformed human mesothelial cellsMaurizio Bocchetta
Department of Pathology, Cardinal Bernardin Cancer Center, Loyola University Chicago, Maywood, IL 60153, USA
Oncogene 22:81-9. 2003..Our finding is relevant to the process of SV40-mediated human cell transformation, an effect that cannot be accounted for solely by SV40-Tag inhibition of Rb and p53... - Evolving aspects of mesothelioma carcinogenesis: SV40 and genetic predispositionMichele Carbone
Cardinal Bernardin Cancer Center, Loyola University, Maywood, Illinois 60153, USA
J Thorac Oncol 1:169-71. 2006 - Molecular analyses, morphology and immunohistochemistry together differentiate pleural synovial sarcomas from mesotheliomas: clinical implicationsMichele Carbone
Cardinal Bernardin Cancer Centre, Cancer Immunology Program, Department of Pathology, Loyola University Chicago, 2160 South First Ave, Maywood, IL 60153, USA
Anticancer Res 22:3443-8. 2002..SS are sarcomatoid or biphasic malignancies morphologically almost indistinguishable from sarcomatoid or biphasic malignant mesotheliomas (MM)... - Multistep and multifactorial carcinogenesis: when does a contributing factor become a carcinogen?Michele Carbone
Department of Pathology, Cardinal Bernardin Cancer Center, Loyola University Chicago, Room 250, 2160 South First Ave, Maywood, IL 60302, USA
Semin Cancer Biol 14:399-405. 2004.... - Aberrant methylation profile of human malignant mesotheliomas and its relationship to SV40 infectionMakoto Suzuki
Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
Oncogene 24:1302-8. 2005..Our results demonstrate a relationship between SV40 and methylation of multiple genes in MM, indicating that the virus plays a role in the pathogenesis of MM... - Modern criteria to establish human cancer etiologyMichele Carbone
Semin Cancer Biol 14:397-8. 2004 - Development of malignant mesothelioma during treatment for prolymphocytic leukemia: is asbestos or simian virus 40 a link?Tawee Tanvetyanon
Division of Hematology Oncology, Department of Medicine, Loyola University Chicago Stritch School of Medicine, Maywood, IL 60153, USA
Anticancer Res 25:429-33. 2005..It seems possible that fludarabine, an immunosuppressive chemotherapy, accelerated the occurrence and progression of malignant mesothelioma during the therapy for his B-PLL... - SV40 detection in human tumor specimensMichele Carbone
Cancer Res 65:10120-1. 2005 - Modern criteria to establish human cancer etiologyMichele Carbone
Cardinal Bernardin Cancer Center, Department of Pathology, Loyola University Chicago, 2160 South First Avenue, Maywood, IL 60302, USA
Cancer Res 64:5518-24. 2004.... - Cross reactivity between many anti-human antibodies for their hamster homologs provide the tools to study the signal transduction pathway activated by asbestos and SV40 in the malignant mesothelioma modelBarbara Kroczynska
Department of Pathology, Cardinal Bernardin Cancer Center, Loyola University Chicago, Maywood, Illinois 60153, USA
Mol Carcinog 45:537-42. 2006.... - Re: Debate on the link between SV40 and human cancer continuesMichele Carbone
J Natl Cancer Inst 94:229-30. 2002 - Evidence of an important role for SV40 in mesotheliomaHarvey I Pass
Karmanos Cancer Institute, Wayne State University School of Medicine, Harper Hospital, 3990 John R, Suite 2102, Detroit, MI 48201, USA
Thorac Surg Clin 14:489-95. 2004..Unfortunately, the causality issues have been stuck to the issue like a remora on a shark. It is time to study the remora, but our priorities should be on taming the shark... - Molecular pathogenesis of malignant mesothelioma and its relationship to simian virus 40Adi F Gazdar
Hamon Center for Therapeutic Oncology Research and Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
Clin Lung Cancer 5:177-81. 2003..The molecular changes caused by each of these major etiologic factors and their interrelationships are the focus of this review... - Different susceptibility of human mesothelial cells to polyomavirus infection and malignant transformationMichele Carbone
Cardinal Bernardin Cancer Center, Department of Pathology, Loyola University Chicago, 2160 South First Avenue, Maywood, IL 60153, USA
Cancer Res 63:6125-9. 2003..SV40 did not lyse mesothelial cells and caused a high rate of transformation. These findings provide a rationale for the observation that SV40 is found in mesothelioma, rather than the ubiquitous human JCV and BKV... - A phase II trial of tetrathiomolybdate after surgery for malignant mesothelioma: final resultsHarvey I Pass
Department of Cardiothoracic Surgery, New York University School of Medicine, New York, New York 10016, USA
Ann Thorac Surg 86:383-9; discussion 390. 2008..We hypothesized that cytoreduction of malignant pleural mesothelioma followed by TM will delay time to progression...
Research Grants
- SV40 sequences in human tumors: analysis & biologic*Michele Carbone; Fiscal Year: 2006....
- Role of Cell Mediators in Asbestos-SV40 CarcinogenesisMichele Carbone; Fiscal Year: 2009..It is anticipated that the results of the experimens proposed in this application will provide information to design novel preventive and therapeutic approaches for MM. ..