M Carbone

Summary

Affiliation: University of Hawaii
Country: USA

Publications

  1. pmc Blocking of ERK1 and ERK2 sensitizes human mesothelioma cells to doxorubicin
    Arti Shukla
    Department of Pathology, University of Vermont College of Medicine, 89 Beaumont Avenue, Burlington, VT 05405, USA
    Mol Cancer 9:314. 2010
  2. ncbi request reprint The pathogenesis of mesothelioma
    Michele Carbone
    Thoracic Oncology Program, Cancer Research Center of Hawaii, University of Hawaii, Honolulu, Hawaii 96813, USA
    Semin Diagn Pathol 23:56-60. 2006
  3. ncbi request reprint A mesothelioma epidemic in Cappadocia: scientific developments and unexpected social outcomes
    Michele Carbone
    Cancer Research Center of Hawaii, Thoracic Oncology Program, Honolulu, Hawaii 96816, USA
    Nat Rev Cancer 7:147-54. 2007
  4. ncbi request reprint Eighth international mesothelioma interest group
    M Carbone
    Thoracic Oncology, Cancer Research Center of Hawaii, University of Hawaii, Honolulu, HI, USA
    Oncogene 26:6959-67. 2007
  5. pmc Malignant mesothelioma: facts, myths, and hypotheses
    Michele Carbone
    University of Hawaii Cancer Center, University of Hawaii, Honolulu, Hawaii 96813, USA
    J Cell Physiol 227:44-58. 2012
  6. pmc A novel mechanism of late gene silencing drives SV40 transformation of human mesothelial cells
    Michele Carbone
    Thoracic Oncology Program, Cancer Center of Hawaii and Department of Pathology, University of Hawaii Medical School, Honolulu, Hawaii 96813, USA
    Cancer Res 68:9488-96. 2008
  7. pmc Mesothelioma epidemiology, carcinogenesis, and pathogenesis
    Haining Yang
    Cancer Research Center of Hawaii, University of Hawaii, Honolulu, HI 96813, USA
    Curr Treat Options Oncol 9:147-57. 2008
  8. pmc Crocidolite asbestos and SV40 are cocarcinogens in human mesothelial cells and in causing mesothelioma in hamsters
    Barbara Kroczynska
    Thoracic Oncology Program, Cardinal Bernardin Cancer Center, Loyola University Chicago, Maywood, IL 60153, USA
    Proc Natl Acad Sci U S A 103:14128-33. 2006
  9. pmc Programmed necrosis induced by asbestos in human mesothelial cells causes high-mobility group box 1 protein release and resultant inflammation
    Haining Yang
    Cancer Research Center of Hawaii, John A Burns School of Medicine, University of Hawaii, Honolulu, HI 96813, USA
    Proc Natl Acad Sci U S A 107:12611-6. 2010
  10. doi request reprint The relationship between simian virus 40 and mesothelioma
    Zeyana Rivera
    Cancer Research Center of Hawaii and Department of Pathology, University of Hawaii, Honolulu, Hawaii, USA
    Curr Opin Pulm Med 14:316-21. 2008

Research Grants

Collaborators

Detail Information

Publications48

  1. pmc Blocking of ERK1 and ERK2 sensitizes human mesothelioma cells to doxorubicin
    Arti Shukla
    Department of Pathology, University of Vermont College of Medicine, 89 Beaumont Avenue, Burlington, VT 05405, USA
    Mol Cancer 9:314. 2010
    ..Using the MEK1/2 inhibitor, U0126 and stably transfected shERK1 and shERK2 MM cell lines, we show that inhibition of both ERK1 and 2 sensitizes MM cells to Dox...
  2. ncbi request reprint The pathogenesis of mesothelioma
    Michele Carbone
    Thoracic Oncology Program, Cancer Research Center of Hawaii, University of Hawaii, Honolulu, Hawaii 96813, USA
    Semin Diagn Pathol 23:56-60. 2006
    ..Moreover, these data provide a rationale for the observation that only a fraction of heavily exposed asbestos workers developed mesothelioma, and novel targets for prevention and therapy...
  3. ncbi request reprint A mesothelioma epidemic in Cappadocia: scientific developments and unexpected social outcomes
    Michele Carbone
    Cancer Research Center of Hawaii, Thoracic Oncology Program, Honolulu, Hawaii 96816, USA
    Nat Rev Cancer 7:147-54. 2007
    ....
  4. ncbi request reprint Eighth international mesothelioma interest group
    M Carbone
    Thoracic Oncology, Cancer Research Center of Hawaii, University of Hawaii, Honolulu, HI, USA
    Oncogene 26:6959-67. 2007
    ..The result is a comprehensive review of the research field of asbestos carcinogenesis and mesothelioma, and of the progress that has been made in recent years in both basic and clinical sciences...
  5. pmc Malignant mesothelioma: facts, myths, and hypotheses
    Michele Carbone
    University of Hawaii Cancer Center, University of Hawaii, Honolulu, Hawaii 96813, USA
    J Cell Physiol 227:44-58. 2012
    ..Genetic predisposition, radiation exposure and viral infection are co-factors that can alone or together with asbestos and erionite cause MM. J. Cell. Physiol. 227: 44-58, 2012. © 2011 Wiley Periodicals, Inc...
  6. pmc A novel mechanism of late gene silencing drives SV40 transformation of human mesothelial cells
    Michele Carbone
    Thoracic Oncology Program, Cancer Center of Hawaii and Department of Pathology, University of Hawaii Medical School, Honolulu, Hawaii 96813, USA
    Cancer Res 68:9488-96. 2008
    ..Our results reveal a novel biological mechanism responsible for the suppression of late viral gene products, an important step in viral carcinogenesis in humans...
  7. pmc Mesothelioma epidemiology, carcinogenesis, and pathogenesis
    Haining Yang
    Cancer Research Center of Hawaii, University of Hawaii, Honolulu, HI 96813, USA
    Curr Treat Options Oncol 9:147-57. 2008
    ..It is hoped that the identification of this putative mesothelioma gene will lead to novel mechanistically driven preventive and therapeutic approaches...
  8. pmc Crocidolite asbestos and SV40 are cocarcinogens in human mesothelial cells and in causing mesothelioma in hamsters
    Barbara Kroczynska
    Thoracic Oncology Program, Cardinal Bernardin Cancer Center, Loyola University Chicago, Maywood, IL 60153, USA
    Proc Natl Acad Sci U S A 103:14128-33. 2006
    ..Our results indicate that mineral fibers and viruses can be cocarcinogens and suggest that lower amounts of asbestos may be sufficient to cause MM in individuals infected with SV40...
  9. pmc Programmed necrosis induced by asbestos in human mesothelial cells causes high-mobility group box 1 protein release and resultant inflammation
    Haining Yang
    Cancer Research Center of Hawaii, John A Burns School of Medicine, University of Hawaii, Honolulu, HI 96813, USA
    Proc Natl Acad Sci U S A 107:12611-6. 2010
    ..Chemopreventive approaches aimed at inhibiting the chronic inflammatory response, and especially blocking HMGB1, may decrease the risk of malignant mesothelioma among asbestos-exposed cohorts...
  10. doi request reprint The relationship between simian virus 40 and mesothelioma
    Zeyana Rivera
    Cancer Research Center of Hawaii and Department of Pathology, University of Hawaii, Honolulu, Hawaii, USA
    Curr Opin Pulm Med 14:316-21. 2008
    ..Simian virus 40 is present in some human malignant mesotheliomas. The evidence in favor and against a pathogenic role of simian virus 40 in malignant mesothelioma is discussed in this review...
  11. pmc TNF-alpha inhibits asbestos-induced cytotoxicity via a NF-kappaB-dependent pathway, a possible mechanism for asbestos-induced oncogenesis
    Haining Yang
    Thoracic Oncology Program, Cardinal Bernardin Cancer Center, Loyola University Chicago, Maywood, IL 60153, USA
    Proc Natl Acad Sci U S A 103:10397-402. 2006
    ....
  12. ncbi request reprint Identification of intelectin overexpression in malignant pleural mesothelioma by serial analysis of gene expression (SAGE)
    Anil Wali
    Thoracic Oncology Program, Karmanos Cancer Institute, and John D Dingell VA Medical Center, Wayne State University, 3990 John R, Suite 2102, Detroit, MI 48201, USA
    Lung Cancer 48:19-29. 2005
    ..Intelectin overexpression in mesothelioma could have potential screening, and therapeutic implications...
  13. ncbi request reprint Mesothelioma
    Michele Carbone
    Thoracic Oncology Program, Cancer Research Center of Hawai i, USA
    Hawaii Med J 66:48-50. 2007
    ..The public health and litigation issues, together with the economics surrounding mesothelioma research and therapy are also discussed...
  14. ncbi request reprint Chemotherapy of malignant pleural mesothelioma
    Pietro Bertino
    Cancer Research Center of Hawaii and Department of Pathology, University of Hawaii, 651 Ilalo Street, BSB Room 231, Honolulu, HI 96813, USA
    Expert Opin Pharmacother 10:99-107. 2009
    ..Although the outcome for patients remains poor, there has been definite progress in the systemic treatment of this disease within the past 5 years...
  15. ncbi request reprint Gene expression profiles predict survival and progression of pleural mesothelioma
    Harvey I Pass
    Thoracic Oncology, Karmanos Cancer Institute, Wayne State University, Detroit, MI 48201, USA
    Clin Cancer Res 10:849-59. 2004
    ..We hypothesized that gene expression profiles could predict time to progression and survival in surgically cytoreduced pleural mesothelioma of all stages...
  16. ncbi request reprint Spindle cell tumors of the pleura: differential diagnosis
    Monica Rdzanek
    Thoracic Oncology Program, Cardinal Bernardin Cancer Center, Loyola University, Maywood, Illinois, USA
    Semin Diagn Pathol 23:44-55. 2006
    ....
  17. ncbi request reprint Some oral poliovirus vaccines were contaminated with infectious SV40 after 1961
    Rochelle Cutrone
    Thoracic Oncology Program, Cardinal Bernardin Cancer Center, Loyola University, Chicago, Illinois, USA
    Cancer Res 65:10273-9. 2005
    ..Moreover, our results indicate possible geographic differences in SV40 exposure and offer a possible explanation for the different percentage of SV40-positive tumors detected in some laboratories...
  18. ncbi request reprint The role of environmental carcinogens, viruses and genetic predisposition in the pathogenesis of mesothelioma
    Amy Powers
    Loyola University Chicago, Cardinal Bernardin Cancer Center, Maywood, Illinois 60153, USA
    Cancer Biol Ther 1:348-53. 2002
    ..The challenge for future research is to establish how these apparently very different factors interact to cause mesotheliomas...
  19. pmc Cellular and molecular parameters of mesothelioma
    Maria E Ramos-Nino
    Department of Pathology, University of Vermont College of Medicine, Burlington, Vermont 05405, USA
    J Cell Biochem 98:723-34. 2006
    ..These mechanistic approaches offer new hope for early detection and treatment of these devastating tumors...
  20. ncbi request reprint Genetic predisposition to fiber carcinogenesis causes a mesothelioma epidemic in Turkey
    A Umran Dogan
    Department of Geological Engineering, Ankara University, Ankara, Turkey
    Cancer Res 66:5063-8. 2006
    ..This is the first time that genetics is shown to influence mineral fiber carcinogenesis...
  21. ncbi request reprint Malignant pleural mesothelioma
    Harvey I Pass
    Department of Surgery, Wayne State University Medical School, Detroit, Michigan, USA
    Curr Probl Cancer 28:93-174. 2004
  22. ncbi request reprint Asbestos exposure, pleural mesothelioma, and serum osteopontin levels
    Harvey I Pass
    Department of Surgery, Wayne State University, Karmanos Cancer Institute, John A Dingell Veterans Hospital, Detroit, Mich, USA
    N Engl J Med 353:1564-73. 2005
    ....
  23. ncbi request reprint Lung diseases due to environmental exposures to erionite and asbestos in Turkey
    Salih Emri
    Department of Chest Diseases, Hacettepe Medical Faculty, Hacettepe University Hospital, Sihhiye, 06100 Ankara, Turkey
    Toxicol Lett 127:251-7. 2002
    ..An additional recent genetic-epidemiological study showed that there are some families, which are genetically predisposed to mesothelioma...
  24. ncbi request reprint The pathogenesis of mesothelioma
    Michele Carbone
    Cancer Immunology Program, Cardinal Bernardin Cancer Center, Department of Pathology, Loyola University Chicago, USA
    Semin Oncol 29:2-17. 2002
    ..Mesothelioma appears to have a complex etiology in which environmental carcinogens (asbestos and erionite), ionizing radiation, viruses, and genetic factors act alone or in concert to cause malignancy...
  25. ncbi request reprint Pathogenesis of malignant mesothelioma
    Michele Carbone
    Cancer Immunology Program, Department of Pathology, Cardinal Bernardin Cancer Center, Loyola University Chicago, Maywood, IL 60153, USA
    Clin Lung Cancer 5:S46-50. 2004
    ..Currently available therapies for MM prolong survival by a few months at most. An SV40 vaccine is being developed for human use and it is hoped that it may reduce the incidence of MM in asbestos workers...
  26. pmc HGF mediates cell proliferation of human mesothelioma cells through a PI3K/MEK5/Fra-1 pathway
    Maria E Ramos-Nino
    University of Vermont College of Medicine, Department of Pathology, 89 Beaumont Avenue HSRF 216, Burlington, VT 05405, USA
    Am J Respir Cell Mol Biol 38:209-17. 2008
    ..Data suggest that HGF-induced effects in some MM cells are mediated via activation of a novel PI3K/ERK5/Fra-1 feedback pathway that might explain tumor-specific effects of c-Met inhibitors on MM and other tumors...
  27. doi request reprint Extrapleural pneumonectomy versus pleurectomy/decortication in the surgical management of malignant pleural mesothelioma: results in 663 patients
    Raja M Flores
    Thoracic Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    J Thorac Cardiovasc Surg 135:620-6, 626.e1-3. 2008
    ..We performed a multi-institutional study to increase statistical power to detect significant differences in outcome between extrapleural pneumonectomy and pleurectomy/decortication...
  28. doi request reprint Ranpirnase as a potential antitumor ribonuclease treatment for mesothelioma and other malignancies
    Amanda K Beck
    New York University School of Medicine, 530 First Ave, Suite 9V, New York, NY 10016, USA
    Future Oncol 4:341-9. 2008
    ..Owing to its selective destruction of malignant cells and favorable toxicology profile, ranpirnase is a promising antitumor agent with ideal attributes that are generally lacking in conventional cytotoxic drugs...
  29. ncbi request reprint Soluble mesothelin-related peptide level elevation in mesothelioma serum and pleural effusions
    Harvey I Pass
    Department of Cardiothoracic Surgery, Division of Thoracic Surgery, New York University School of Medicine, New York, New York 10016, USA
    Ann Thorac Surg 85:265-72; discussion 272. 2008
    ..Soluble mesothelin-related peptide (SMRP) is a potential marker for malignant pleural mesothelioma (MPM), which may be useful for screening high-risk asbestos-exposed individuals...
  30. ncbi request reprint A cytokeratin- and calretinin-negative staining sarcomatoid malignant mesothelioma
    Michael G Hurtuk
    Cardinal Bernadin Cancer Center, Cancer Immunology Program, Department of Pathology, Loyola University Chicago, Maywood, IL 60153, USA
    Anticancer Res 24:3097-102. 2004
    ....
  31. ncbi request reprint SV40 and human tumours: myth, association or causality?
    Adi F Gazdar
    Hamon Center for Therapeutic Oncology Research and Department of Pathology, University of Texas Southwestern Medical Centre, Dallas, Texas 75390, USA
    Nat Rev Cancer 2:957-64. 2002
    ..How did a simian virus infect humans and is the virus a passenger in tumours or is it important in their pathogenesis?..
  32. ncbi request reprint Progressive aberrant methylation of the RASSF1A gene in simian virus 40 infected human mesothelial cells
    Shinichi Toyooka
    Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, Texas, TX 75390, USA
    Oncogene 21:4340-4. 2002
    ..These data, together with our previous findings, support a causal relationship between SV40 infection, progressive RASSF1A methylation and its silencing, and the pathogenesis of mesothelioma...
  33. ncbi request reprint SV40 infection induces telomerase activity in human mesothelial cells
    Rudy Foddis
    Cancer Immunology Program, Department of Pathology, Cardinal Bernardin Cancer Center, Loyola University Chicago, Maywood, Illinois, IL 60153, USA
    Oncogene 21:1434-42. 2002
    ..Induction of telomerase activity by SV40 may be related to the very high rate of mesothelial cell immortalization that is characteristically associated with SV40 infection of mesothelial cells...
  34. ncbi request reprint Notch-1 induction, a novel activity of SV40 required for growth of SV40-transformed human mesothelial cells
    Maurizio Bocchetta
    Department of Pathology, Cardinal Bernardin Cancer Center, Loyola University Chicago, Maywood, IL 60153, USA
    Oncogene 22:81-9. 2003
    ..Our finding is relevant to the process of SV40-mediated human cell transformation, an effect that cannot be accounted for solely by SV40-Tag inhibition of Rb and p53...
  35. ncbi request reprint Evolving aspects of mesothelioma carcinogenesis: SV40 and genetic predisposition
    Michele Carbone
    Cardinal Bernardin Cancer Center, Loyola University, Maywood, Illinois 60153, USA
    J Thorac Oncol 1:169-71. 2006
  36. ncbi request reprint Molecular analyses, morphology and immunohistochemistry together differentiate pleural synovial sarcomas from mesotheliomas: clinical implications
    Michele Carbone
    Cardinal Bernardin Cancer Centre, Cancer Immunology Program, Department of Pathology, Loyola University Chicago, 2160 South First Ave, Maywood, IL 60153, USA
    Anticancer Res 22:3443-8. 2002
    ..SS are sarcomatoid or biphasic malignancies morphologically almost indistinguishable from sarcomatoid or biphasic malignant mesotheliomas (MM)...
  37. ncbi request reprint Multistep and multifactorial carcinogenesis: when does a contributing factor become a carcinogen?
    Michele Carbone
    Department of Pathology, Cardinal Bernardin Cancer Center, Loyola University Chicago, Room 250, 2160 South First Ave, Maywood, IL 60302, USA
    Semin Cancer Biol 14:399-405. 2004
    ....
  38. ncbi request reprint Aberrant methylation profile of human malignant mesotheliomas and its relationship to SV40 infection
    Makoto Suzuki
    Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Oncogene 24:1302-8. 2005
    ..Our results demonstrate a relationship between SV40 and methylation of multiple genes in MM, indicating that the virus plays a role in the pathogenesis of MM...
  39. ncbi request reprint Modern criteria to establish human cancer etiology
    Michele Carbone
    Semin Cancer Biol 14:397-8. 2004
  40. ncbi request reprint Development of malignant mesothelioma during treatment for prolymphocytic leukemia: is asbestos or simian virus 40 a link?
    Tawee Tanvetyanon
    Division of Hematology Oncology, Department of Medicine, Loyola University Chicago Stritch School of Medicine, Maywood, IL 60153, USA
    Anticancer Res 25:429-33. 2005
    ..It seems possible that fludarabine, an immunosuppressive chemotherapy, accelerated the occurrence and progression of malignant mesothelioma during the therapy for his B-PLL...
  41. ncbi request reprint SV40 detection in human tumor specimens
    Michele Carbone
    Cancer Res 65:10120-1. 2005
  42. ncbi request reprint Modern criteria to establish human cancer etiology
    Michele Carbone
    Cardinal Bernardin Cancer Center, Department of Pathology, Loyola University Chicago, 2160 South First Avenue, Maywood, IL 60302, USA
    Cancer Res 64:5518-24. 2004
    ....
  43. ncbi request reprint Cross reactivity between many anti-human antibodies for their hamster homologs provide the tools to study the signal transduction pathway activated by asbestos and SV40 in the malignant mesothelioma model
    Barbara Kroczynska
    Department of Pathology, Cardinal Bernardin Cancer Center, Loyola University Chicago, Maywood, Illinois 60153, USA
    Mol Carcinog 45:537-42. 2006
    ....
  44. ncbi request reprint Re: Debate on the link between SV40 and human cancer continues
    Michele Carbone
    J Natl Cancer Inst 94:229-30. 2002
  45. ncbi request reprint Evidence of an important role for SV40 in mesothelioma
    Harvey I Pass
    Karmanos Cancer Institute, Wayne State University School of Medicine, Harper Hospital, 3990 John R, Suite 2102, Detroit, MI 48201, USA
    Thorac Surg Clin 14:489-95. 2004
    ..Unfortunately, the causality issues have been stuck to the issue like a remora on a shark. It is time to study the remora, but our priorities should be on taming the shark...
  46. ncbi request reprint Molecular pathogenesis of malignant mesothelioma and its relationship to simian virus 40
    Adi F Gazdar
    Hamon Center for Therapeutic Oncology Research and Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Clin Lung Cancer 5:177-81. 2003
    ..The molecular changes caused by each of these major etiologic factors and their interrelationships are the focus of this review...
  47. ncbi request reprint Different susceptibility of human mesothelial cells to polyomavirus infection and malignant transformation
    Michele Carbone
    Cardinal Bernardin Cancer Center, Department of Pathology, Loyola University Chicago, 2160 South First Avenue, Maywood, IL 60153, USA
    Cancer Res 63:6125-9. 2003
    ..SV40 did not lyse mesothelial cells and caused a high rate of transformation. These findings provide a rationale for the observation that SV40 is found in mesothelioma, rather than the ubiquitous human JCV and BKV...
  48. doi request reprint A phase II trial of tetrathiomolybdate after surgery for malignant mesothelioma: final results
    Harvey I Pass
    Department of Cardiothoracic Surgery, New York University School of Medicine, New York, New York 10016, USA
    Ann Thorac Surg 86:383-9; discussion 390. 2008
    ..We hypothesized that cytoreduction of malignant pleural mesothelioma followed by TM will delay time to progression...

Research Grants13

  1. SV40 sequences in human tumors: analysis & biologic*
    Michele Carbone; Fiscal Year: 2006
    ....
  2. Role of Cell Mediators in Asbestos-SV40 Carcinogenesis
    Michele Carbone; Fiscal Year: 2009
    ..It is anticipated that the results of the experimens proposed in this application will provide information to design novel preventive and therapeutic approaches for MM. ..