Research Topics
Species | Anne R CappolaSummaryAffiliation: University of Pennsylvania Country: USA Publications
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Publications
Insulin-like growth factor I and interleukin-6 contribute synergistically to disability and mortality in older womenAnne R Cappola
Department of Medicine, University of Maryland, Baltimore, Maryland 21201, USA
J Clin Endocrinol Metab 88:2019-25. 2003..The joint effects of IGF-I and IL-6 may be important targets for treatments to prevent or minimize disability associated with aging...
DHEAS levels and mortality in disabled older women: the Women's Health and Aging Study IAnne R Cappola
Division of Endocrinology, Diabetes, and Metabolism, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6021, USA
J Gerontol A Biol Sci Med Sci 61:957-62. 2006..Low DHEAS levels are associated with mortality in older men, but the relationship between DHEAS levels and mortality in women is not clearly defined...- Thyroid status, cardiovascular risk, and mortality in older adultsAnne R Cappola
Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia 19104 6021, USA
JAMA 295:1033-41. 2006..Previous studies have suggested that subclinical abnormalities in thyroid-stimulating hormone levels are associated with detrimental effects on the cardiovascular system... - Hypothyroidism and atherosclerosisAnne R Cappola
Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, 19104, USA
J Clin Endocrinol Metab 88:2438-44. 2003 - Determinants of serum total and free testosterone levels in women over the age of 65 yearsAnne R Cappola
Division of Endocrinology, Diabetes, and Metabolism, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6021, USA
J Clin Endocrinol Metab 92:509-16. 2007..Little is known about testosterone (T) levels and their determinants in women of late postmenopausal age... - Relationship of low plasma klotho with poor grip strength in older community-dwelling adults: the InCHIANTI studyRichard D Semba
Department of Ophthalmology, The Johns Hopkins University School of Medicine, Smith Building, M015, 400 N Broadway, Baltimore, MD 21287, USA
Eur J Appl Physiol 112:1215-20. 2012..20, standard error = 0.35, P = 0.0009) in adults with plasma klotho <681 pg/mL. These results suggest that older adults with lower plasma klotho have poor skeletal muscle strength... - Trajectories of dehydroepiandrosterone sulfate predict mortality in older adults: the cardiovascular health studyAnne R Cappola
SCM, Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, University of Pennsylvania School of Medicine, 764 CRB, 415 Curie Boulevard, Philadelphia, PA 19104, USA
J Gerontol A Biol Sci Med Sci 64:1268-74. 2009..Assessment of an individual's ability to maintain a DHEAS set point, through examination of multiple DHEAS levels over time, may provide insight into biologic aging... - The natural history of subclinical hypothyroidism in the elderly: the cardiovascular health studyLily L Somwaru
Division of Endocrinology, Diabetes, and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104 5160, USA
J Clin Endocrinol Metab 97:1962-9. 2012..Studies of long-term outcomes of subclinical hypothyroidism have assessed only baseline thyroid function, despite natural transitions to euthyroidism and overt hypothyroidism over time... - Relationship of low-circulating "anti-aging" klotho hormone with disability in activities of daily living among older community-dwelling adultsCandace L Crasto
Department of Ophthalmology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Rejuvenation Res 15:295-301. 2012..Low plasma klotho concentrations were independently associated with ADL disability among older community-dwelling men and women... - Relationship of serum fibroblast growth factor 23 with cardiovascular disease in older community-dwelling womenMansi Dalal
Department of Ophthalmology, Johns Hopkins University School of Medicine, M015, Smith Building, 400 North Broadway, Baltimore, Maryland 21287, USA
Eur J Endocrinol 165:797-803. 2011..The aim of this study was to determine whether serum FGF23 is independently associated with cardiovascular disease in older community-dwelling women... - Plasma klotho and cardiovascular disease in adultsRichard D Semba
Department of Ophthalmology, School of Medicine, The Johns Hopkins University, Baltimore, Maryland, USA
J Am Geriatr Soc 59:1596-601. 2011..To determine whether plasma klotho, a recently discovered hormone that has been implicated in atherosclerosis, is related to prevalent cardiovascular disease (CVD) in adults... - Higher serum free testosterone concentration in older women is associated with greater bone mineral density, lean body mass, and total fat mass: the cardiovascular health studyChevon M Rariy
Division of Endocrinology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
J Clin Endocrinol Metab 96:989-96. 2011..The physiological importance of endogenous testosterone (T) in older women is poorly understood... - White blood cell counts, insulin-like growth factor-1 levels, and frailty in community-dwelling older womenSean X Leng
Division of Geriatric Medicine and Gerontology, 5505 Hopkins Bayview Circle, Johns Hopkins School of Medicine, Baltimore, MD 21224, USA
J Gerontol A Biol Sci Med Sci 64:499-502. 2009..WBC subpopulations are known to produce IGF-1 and express IGF-1 receptors in vitro. However, in vivo relationships between WBC and IGF-1 and their joint contribution to frailty have not been investigated... - Multiple hormonal deficiencies in anabolic hormones are found in frail older women: the Women's Health and Aging studiesAnne R Cappola
Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, University of Pennsylvania School of Medicine, 415 Curie Blvd, Philadelphia, PA 19104, USA
J Gerontol A Biol Sci Med Sci 64:243-8. 2009..We hypothesized that associations with frailty would most likely manifest in the presence of deficits in multiple anabolic hormones... - Low Serum Selenium Is Associated with Anemia Among Older Women Living in the Community: the Women's Health and Aging Studies I and IIRichard D Semba
The Johns Hopkins Medical Institutions, Baltimore, MD, USA
Biol Trace Elem Res 112:97-107. 2006..47-0.84), adjusting for age, education, chronic diseases, iron status, and serum interleukin-6. We conclude that low serum selenium is independently associated with anemia among older women living in the community... - Plasma klotho and mortality risk in older community-dwelling adultsRichard D Semba
Baltimore, MD 21287, USA
J Gerontol A Biol Sci Med Sci 66:794-800. 2011..It is not known whether there is a relationship between plasma levels of secreted klotho protein and longevity in humans... - Cardiovascular disease is associated with greater incident dehydroepiandrosterone sulfate decline in the oldest old: the cardiovascular health study all stars studyJason L Sanders
Department of Medicine, School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA
J Am Geriatr Soc 58:421-6. 2010..To describe cross-sectional and longitudinal associations with dehydroepiandrosterone sulfate (DHEAS) and change in DHEAS with age... - Association between interleukin-6 and lower extremity function after hip fracture--the role of muscle mass and strengthRam R Miller
Division of Gerontology, Department of Epidemiology and Preventive Medicine, University of Maryland, Baltimore, Maryland 21201, USA
J Am Geriatr Soc 56:1050-6. 2008..To examine whether an effect on muscle mass or strength explains the association between interleukin-6 (IL-6) and lower extremity function in the year after hip fracture... - Longitudinal changes in thyroid function in the oldest old and survival: the cardiovascular health study all-stars studyAvantika C Waring
Division of Endocrinology, Diabetes, and Metabolism, Perelman School of Medicine at the University of Pennsylvania, 12 136 Translational Research Center, 3400 Civic Center Boulevard, Philadelphia, Pennsylvania 19104 5160, USA
J Clin Endocrinol Metab 97:3944-50. 2012..Data on thyroid function in the oldest old are sparse, and existing studies show conflicting evidence on the relationship between thyroid function and mortality in this age group... 
Hyperglycemia and incidence of frailty and lower extremity mobility limitations in older womenRita R Kalyani
Divisions of Endocrinology, Johns Hopkins University, Baltimore, Maryland 21287, USA
J Am Geriatr Soc 60:1701-7. 2012..To determine the degree to which hyperglycemia predicts the development of frailty and lower extremity mobility limitations...- Serum fibroblast growth factor-23 and risk of incident chronic kidney disease in older community-dwelling womenRichard D Semba
Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
Clin J Am Soc Nephrol 7:85-91. 2012..This study aimed to determine whether circulating FGF23 predicts incident CKD in community-dwelling women... - Thyroid autoantibodies are associated with a reduced prevalence of frailty in community-dwelling older womenGeorge C Wang
Division of Geriatric Medicine and Gerontology, Johns Hopkins University School of Medicine, 5505 Hopkins Bayview Circle, Baltimore, Maryland 21224, USA
J Clin Endocrinol Metab 95:1161-8. 2010..These trends were not observed with antinuclear antibodies. Conclusion: Independent of thyroid function status, community-dwelling older women who are seropositive for TgAbs and TPOAbs are less likely to be frail than seronegative women... - Effects of metformin and leuprolide acetate on insulin resistance and testosterone levels in nondiabetic postmenopausal women: a randomized, placebo-controlled trialShrita M Patel
Division of Endocrinology, Diabetes, and Metabolism, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
Fertil Steril 94:2161-6. 2010..To determine whether insulin sensitizers lower androgen levels and whether androgen suppression improves insulin resistance in nondiabetic postmenopausal women... - Predictors of thyroid hormone initiation in older adults: results from the cardiovascular health studyLily L Somwaru
Division of Endocrinology, Diabetes, and Metabolism, University of Pennsylvania School of Medicine, Philadelphia, USA
J Gerontol A Biol Sci Med Sci 66:809-14. 2011..Despite widespread use, there are no data on initiation of thyroid hormone use in older people. We report the prevalence of thyroid hormone use and predictors of thyroid hormone initiation in a population of older men and women... - Association of serum vitamin D levels with inflammatory response following hip fracture: the Baltimore Hip StudiesRam R Miller
Division of Gerontology, Department of Epidemiology and Preventive Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA
J Gerontol A Biol Sci Med Sci 62:1402-6. 2007..Vitamin D, known for its role in calcium homeostasis, may also regulate immune function. Whether vitamin D deficiency at the time of hip fracture is associated with the inflammatory response postfracture is not known... - Higher serum testosterone concentration in older women is associated with insulin resistance, metabolic syndrome, and cardiovascular diseaseShrita M Patel
Division of Endocrinology, Diabetes, and Metabolism, University of Pennsylvania School of Medicine, 415 Curie Boulevard, Philadelphia, Pennsylvania 19104, USA
J Clin Endocrinol Metab 94:4776-84. 2009..Early postmenopausal women with higher testosterone (T) levels have increased insulin resistance (IR) and cardiovascular risk factors, but whether this translates into increased cardiovascular disease later in life is unknown... - Frailty status and altered glucose-insulin dynamicsRita Rastogi Kalyani
Division of Endocrinology and Metabolism, Department of Medicine, Johns Hopkins University School of Medicine, 1830 East Monument Street, Suite 333, Baltimore, MD 21287, USA
J Gerontol A Biol Sci Med Sci 67:1300-6. 2012..We examined women in their 80s and 90s and evaluated the hypothesis that abnormalities in the dynamic response of glucose and insulin to a glucose load are associated with frailty status... - Serum 25-hydroxyvitamin D and pulmonary function in older disabled community-dwelling womenRichard D Semba
Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
J Gerontol A Biol Sci Med Sci 67:683-9. 2012..Our objective was to examine the relationship between serum 25-hydroxyvitamin D (25[OH]D), serum parathyroid hormone, and pulmonary function in older women... - Low serum 25-hydroxyvitamin D concentrations are associated with greater all-cause mortality in older community-dwelling womenRichard D Semba
Department of Ophthalmology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, MD 21287, USA
Nutr Res 29:525-30. 2009..4 nmol/L) of 25(OH)D in a multivariate Cox proportional hazards model adjusting for demographics, season, and conventional risk factors. Older community-dwelling women with low 25(OH)D levels are at an increased risk of death... - Persistent subclinical hypothyroidism and cardiovascular risk in the elderly: the cardiovascular health studyKristen A Hyland
Sc M, Division of Endocrinology, Diabetes, and Metabolism, Perelman School of Medicine at the University of Pennsylvania, 12 136 Translational Research Center, 3400 Civic Center Boulevard, Philadelphia, Pennsylvania 19104 5160
J Clin Endocrinol Metab 98:533-40. 2013..Conclusions: Our data do not support increased risk of CHD, HF, or CV death in older adults with persistent subclinical hypothyroidism... - Resting metabolic rate in old-old women with and without frailty: variability and estimation of energy requirementsCarlos O Weiss
Department of Medicine, School of Medicine, Johns Hopkins University, Baltimore, Maryland 21224, USA
J Am Geriatr Soc 60:1695-700. 2012..To measure resting metabolic rate (RMR) in old-old adults living in the community and examine the association between measured RMR and frailty status and compare it with expected RMR generated by a predictive equation... - High frequency of and factors associated with thyroid hormone over-replacement and under-replacement in men and women aged 65 and overLily L Somwaru
Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
J Clin Endocrinol Metab 94:1342-5. 2009..Thyroid hormone use is common in older populations, but the frequency of over- or under-replacement is debated... - Low serum selenium and total carotenoids predict mortality among older women living in the community: the women's health and aging studiesAmanda L Ray
The Johns Hopkins Medical Institutions, Baltimore, MD, USA
J Nutr 136:172-6. 2006..77, 95% CI 0.64-0.84/1 SD increase in log(e) total carotenoids; P = 0.009) were associated with a lower risk of mortality. Women living in the community who have higher serum selenium and carotenoids are at a lower risk of death... - Serum levels of insulin-like growth factor-I (IGF-I) and dehydroepiandrosterone sulfate (DHEA-S), and their relationships with serum interleukin-6, in the geriatric syndrome of frailtySean X Leng
Johns Hopkins University School of Medicine, Baltimore, MD, USA
Aging Clin Exp Res 16:153-7. 2004..The trend toward an inverse correlation between IGF-I and IL-6 in the frail, but not the non-frail group, suggests potential interaction between endocrine and immune/cytokine dysregulation that requires further study in larger cohorts... - Higher levels and blunted diurnal variation of cortisol in frail older womenRavi Varadhan
Division of Geriatric Medicine and Gerontology, School of Medicine, John Hopkins University, Baltimore, MD, USA
J Gerontol A Biol Sci Med Sci 63:190-5. 2008..We evaluated whether higher levels and blunted diurnal variation of salivary cortisol are cross-sectionally associated with frailty burden... - Dehydroepiandrosterone sulfate and postmenopausal womenRachna M Goel
Division of Endocrinology, Diabetes, and Metabolism, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
Curr Opin Endocrinol Diabetes Obes 18:171-6. 2011..The goal of this article is to critically review published studies to determine if there is a role for DHEA supplementation in postmenopausal women... - Integrated management of type 2 diabetes mellitus and depression treatment to improve medication adherence: a randomized controlled trialHillary R Bogner
Department of Family Medicine and Community Health, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Ann Fam Med 10:15-22. 2012.... - Sex hormones are associated with right ventricular structure and function: The MESA-right ventricle studyCorey E Ventetuolo
Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, New York, USA
Am J Respir Crit Care Med 183:659-67. 2011..Sex hormones have effects on the left ventricle, but hormonal influences on the right ventricle (RV) are unknown... - The intersection of cancer and aging: establishing the need for breast cancer rehabilitationKathryn H Schmitz
Division of Clinical Epidemiology, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, 921 Blockley Hall, 423 Guardian Drive, Philadelphia, PA 19104, USA
Cancer Epidemiol Biomarkers Prev 16:866-72. 2007.... - Persistent changes in interleukin-6 and lower extremity function following hip fractureRam R Miller
University of Maryland, School of Medicine, Division of Gerontology, Department of Epidemiology and Preventive Medicine, 660 W Redwood St, Suite 200, Baltimore, MD 21201, USA
J Gerontol A Biol Sci Med Sci 61:1053-8. 2006..Although an inflammatory reaction would be expected following a hip fracture, whether the degree of this response is associated with adverse functional outcomes is unknown... - Factors impacting the departure rates of female and male junior medical school faculty: evidence from a longitudinal analysisRebecca M Speck
Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA
J Womens Health (Larchmt) 21:1059-65. 2012..Our objective was to investigate the association of individual level risk factors, track of academic appointment, and use of institutional leave polices with departure in junior faculty of a research-intensive school of medicine... - Insulin sensitizing pharmacotherapy for prevention of myocardial infarction in patients with diabetes mellitusWilliam H Sauer
Cardiovascular Division, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania
Am J Cardiol 97:651-4. 2006.... - Association of total insulin-like growth factor-I, insulin-like growth factor binding protein-1 (IGFBP-1), and IGFBP-3 levels with incident coronary events and ischemic strokeRobert C Kaplan
Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, New York 10461, USA, and Department of Medicine, Lady Davis Research Institute of Jewish General Hospital, Montreal, Quebec, Canada
J Clin Endocrinol Metab 92:1319-25. 2007..Prior observational studies have demonstrated that the GH/IGF axis is associated with cardiovascular disease. However, this association has not been extensively studied among older adults... - Subclinical thyroid dysfunction, cardiac function, and the risk of heart failure. The Cardiovascular Health studyNicolas Rodondi
Department of Ambulatory Care and Community Medicine, University of Lausanne, Lausanne, Switzerland
J Am Coll Cardiol 52:1152-9. 2008..The goal of this study was to determine whether subclinical thyroid dysfunction was associated with incident heart failure (HF) and echocardiogram abnormalities... - Insulin-like growth factor-(IGF)-axis, inflammation, and glucose intolerance among older adultsSwapnil N Rajpathak
Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY 11375, USA
Growth Horm IGF Res 18:166-73. 2008..We did not confirm prior associations of low IGF-I with glucose intolerance in this cohort of older individuals... - Subclinical thyroid dysfunction and the heartAnne R Cappola
J Clin Endocrinol Metab 92:3404-5. 2007 - Is research on hormones and aging finished? No! Just started!Anne R Cappola
J Gerontol A Biol Sci Med Sci 63:696-7. 2008 - High insulinlike growth factor binding protein 1 level predicts incident congestive heart failure in the elderlyRobert C Kaplan
Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY 10461, USA
Am Heart J 155:1006-12. 2008..We investigated the association between fasting plasma levels of IGF-I, IGFBP-1, IGFBP-3, and insulin and risk of incident CHF in the prospective Cardiovascular Health Study...
Research Grants
- Androgens, Myostatin, and Sarcopenia in Older WomenAnne Cappola; Fiscal Year: 2006..abstract_text> ..