Anne Cappola

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. pmc The natural history of subclinical hypothyroidism in the elderly: the cardiovascular health study
    Lily L Somwaru
    Division of Endocrinology, Diabetes, and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104 5160, USA
    J Clin Endocrinol Metab 97:1962-9. 2012
  2. pmc Clinical review: The human experience with ghrelin administration
    Margaret C Garin
    Division of Endocrinology, Diabetes, and Metabolism, Perelman School of Medicine at the University of Pennsylvania, 3400 Civic Center Boulevard, Philadelphia, Pennsylvania 19104 5160, USA
    J Clin Endocrinol Metab 98:1826-37. 2013
  3. pmc Persistent subclinical hypothyroidism and cardiovascular risk in the elderly: the cardiovascular health study
    Kristen A Hyland
    Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, 12 136 Translational Research Center, 3400 Civic Center Boulevard, Philadelphia, Pennsylvania 19104 5160, USA
    J Clin Endocrinol Metab 98:533-40. 2013
  4. pmc Longitudinal changes in thyroid function in the oldest old and survival: the cardiovascular health study all-stars study
    Avantika C Waring
    Division of Endocrinology, Diabetes, and Metabolism, Perelman School of Medicine at the University of Pennsylvania, 12 136 Translational Research Center, 3400 Civic Center Boulevard, Philadelphia, Pennsylvania 19104 5160, USA
    J Clin Endocrinol Metab 97:3944-50. 2012
  5. pmc Multiple hormonal deficiencies in anabolic hormones are found in frail older women: the Women's Health and Aging studies
    Anne R Cappola
    Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, University of Pennsylvania School of Medicine, 415 Curie Blvd, Philadelphia, PA 19104, USA
    J Gerontol A Biol Sci Med Sci 64:243-8. 2009
  6. pmc The hormonal profile of hip fracture female patients differs from community-dwelling peers over a 1-year follow-up period
    A R Cappola
    Division of Endocrinology, Diabetes and Metabolism, University of Pennsylvania School of Medicine, 764 CRB, 415 Curie Blvd, Philadelphia, PA 19104, USA
    Osteoporos Int 22:339-44. 2011
  7. pmc Trajectories of dehydroepiandrosterone sulfate predict mortality in older adults: the cardiovascular health study
    Anne R Cappola
    SCM, Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, University of Pennsylvania School of Medicine, 764 CRB, 415 Curie Boulevard, Philadelphia, PA 19104, USA
    J Gerontol A Biol Sci Med Sci 64:1268-74. 2009
  8. pmc Cardiovascular disease is associated with greater incident dehydroepiandrosterone sulfate decline in the oldest old: the cardiovascular health study all stars study
    Jason L Sanders
    Department of Medicine, School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    J Am Geriatr Soc 58:421-6. 2010
  9. pmc Higher serum free testosterone concentration in older women is associated with greater bone mineral density, lean body mass, and total fat mass: the cardiovascular health study
    Chevon M Rariy
    Division of Endocrinology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Clin Endocrinol Metab 96:989-96. 2011
  10. pmc Sex hormones are associated with right ventricular structure and function: The MESA-right ventricle study
    Corey E Ventetuolo
    Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, New York, USA
    Am J Respir Crit Care Med 183:659-67. 2011

Research Grants

  1. Hormonal trajectories in aging
    Anne Cappola; Fiscal Year: 2007
  2. Hormonal trajectories in aging
    Anne Cappola; Fiscal Year: 2009
  3. Subclinical thyroid dysfunction in the elderly
    Anne R Cappola; Fiscal Year: 2010

Detail Information

Publications21

  1. pmc The natural history of subclinical hypothyroidism in the elderly: the cardiovascular health study
    Lily L Somwaru
    Division of Endocrinology, Diabetes, and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104 5160, USA
    J Clin Endocrinol Metab 97:1962-9. 2012
    ..Studies of long-term outcomes of subclinical hypothyroidism have assessed only baseline thyroid function, despite natural transitions to euthyroidism and overt hypothyroidism over time...
  2. pmc Clinical review: The human experience with ghrelin administration
    Margaret C Garin
    Division of Endocrinology, Diabetes, and Metabolism, Perelman School of Medicine at the University of Pennsylvania, 3400 Civic Center Boulevard, Philadelphia, Pennsylvania 19104 5160, USA
    J Clin Endocrinol Metab 98:1826-37. 2013
    ..Clinical trials have been performed in a variety of patient populations, but there is no comprehensive review of the beneficial and adverse consequences of ghrelin administration to humans...
  3. pmc Persistent subclinical hypothyroidism and cardiovascular risk in the elderly: the cardiovascular health study
    Kristen A Hyland
    Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, 12 136 Translational Research Center, 3400 Civic Center Boulevard, Philadelphia, Pennsylvania 19104 5160, USA
    J Clin Endocrinol Metab 98:533-40. 2013
    ..Objective: We assessed the risks of coronary heart disease (CHD), heart failure (HF), and cardiovascular (CV) death in older adults with persistent subclinical hypothyroidism...
  4. pmc Longitudinal changes in thyroid function in the oldest old and survival: the cardiovascular health study all-stars study
    Avantika C Waring
    Division of Endocrinology, Diabetes, and Metabolism, Perelman School of Medicine at the University of Pennsylvania, 12 136 Translational Research Center, 3400 Civic Center Boulevard, Philadelphia, Pennsylvania 19104 5160, USA
    J Clin Endocrinol Metab 97:3944-50. 2012
    ..Data on thyroid function in the oldest old are sparse, and existing studies show conflicting evidence on the relationship between thyroid function and mortality in this age group...
  5. pmc Multiple hormonal deficiencies in anabolic hormones are found in frail older women: the Women's Health and Aging studies
    Anne R Cappola
    Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, University of Pennsylvania School of Medicine, 415 Curie Blvd, Philadelphia, PA 19104, USA
    J Gerontol A Biol Sci Med Sci 64:243-8. 2009
    ..We hypothesized that associations with frailty would most likely manifest in the presence of deficits in multiple anabolic hormones...
  6. pmc The hormonal profile of hip fracture female patients differs from community-dwelling peers over a 1-year follow-up period
    A R Cappola
    Division of Endocrinology, Diabetes and Metabolism, University of Pennsylvania School of Medicine, 764 CRB, 415 Curie Blvd, Philadelphia, PA 19104, USA
    Osteoporos Int 22:339-44. 2011
    ..Our study suggests progressive hormonal changes that may contribute to severe bone loss during the year following hip fracture...
  7. pmc Trajectories of dehydroepiandrosterone sulfate predict mortality in older adults: the cardiovascular health study
    Anne R Cappola
    SCM, Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, University of Pennsylvania School of Medicine, 764 CRB, 415 Curie Boulevard, Philadelphia, PA 19104, USA
    J Gerontol A Biol Sci Med Sci 64:1268-74. 2009
    ..Assessment of an individual's ability to maintain a DHEAS set point, through examination of multiple DHEAS levels over time, may provide insight into biologic aging...
  8. pmc Cardiovascular disease is associated with greater incident dehydroepiandrosterone sulfate decline in the oldest old: the cardiovascular health study all stars study
    Jason L Sanders
    Department of Medicine, School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    J Am Geriatr Soc 58:421-6. 2010
    ..To describe cross-sectional and longitudinal associations with dehydroepiandrosterone sulfate (DHEAS) and change in DHEAS with age...
  9. pmc Higher serum free testosterone concentration in older women is associated with greater bone mineral density, lean body mass, and total fat mass: the cardiovascular health study
    Chevon M Rariy
    Division of Endocrinology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Clin Endocrinol Metab 96:989-96. 2011
    ..The physiological importance of endogenous testosterone (T) in older women is poorly understood...
  10. pmc Sex hormones are associated with right ventricular structure and function: The MESA-right ventricle study
    Corey E Ventetuolo
    Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, New York, USA
    Am J Respir Crit Care Med 183:659-67. 2011
    ..Sex hormones have effects on the left ventricle, but hormonal influences on the right ventricle (RV) are unknown...
  11. ncbi Insulin-like growth factor I and interleukin-6 contribute synergistically to disability and mortality in older women
    Anne R Cappola
    Department of Medicine, University of Maryland, Baltimore, Maryland 21201, USA
    J Clin Endocrinol Metab 88:2019-25. 2003
    ..The joint effects of IGF-I and IL-6 may be important targets for treatments to prevent or minimize disability associated with aging...
  12. ncbi The intersection of cancer and aging: establishing the need for breast cancer rehabilitation
    Kathryn H Schmitz
    Division of Clinical Epidemiology, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, 921 Blockley Hall, 423 Guardian Drive, Philadelphia, PA 19104, USA
    Cancer Epidemiol Biomarkers Prev 16:866-72. 2007
    ....
  13. ncbi Hypothyroidism and atherosclerosis
    Anne R Cappola
    Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, 19104, USA
    J Clin Endocrinol Metab 88:2438-44. 2003
  14. ncbi Determinants of serum total and free testosterone levels in women over the age of 65 years
    Anne R Cappola
    Division of Endocrinology, Diabetes, and Metabolism, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6021, USA
    J Clin Endocrinol Metab 92:509-16. 2007
    ..Little is known about testosterone (T) levels and their determinants in women of late postmenopausal age...
  15. pmc DHEAS levels and mortality in disabled older women: the Women's Health and Aging Study I
    Anne R Cappola
    Division of Endocrinology, Diabetes, and Metabolism, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6021, USA
    J Gerontol A Biol Sci Med Sci 61:957-62. 2006
    ..Low DHEAS levels are associated with mortality in older men, but the relationship between DHEAS levels and mortality in women is not clearly defined...
  16. pmc Thyroid status, cardiovascular risk, and mortality in older adults
    Anne R Cappola
    Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia 19104 6021, USA
    JAMA 295:1033-41. 2006
    ..Previous studies have suggested that subclinical abnormalities in thyroid-stimulating hormone levels are associated with detrimental effects on the cardiovascular system...
  17. pmc High frequency of and factors associated with thyroid hormone over-replacement and under-replacement in men and women aged 65 and over
    Lily L Somwaru
    Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Clin Endocrinol Metab 94:1342-5. 2009
    ..Thyroid hormone use is common in older populations, but the frequency of over- or under-replacement is debated...
  18. pmc Higher serum testosterone concentration in older women is associated with insulin resistance, metabolic syndrome, and cardiovascular disease
    Shrita M Patel
    Division of Endocrinology, Diabetes, and Metabolism, University of Pennsylvania School of Medicine, 415 Curie Boulevard, Philadelphia, Pennsylvania 19104, USA
    J Clin Endocrinol Metab 94:4776-84. 2009
    ..Early postmenopausal women with higher testosterone (T) levels have increased insulin resistance (IR) and cardiovascular risk factors, but whether this translates into increased cardiovascular disease later in life is unknown...
  19. pmc Effects of metformin and leuprolide acetate on insulin resistance and testosterone levels in nondiabetic postmenopausal women: a randomized, placebo-controlled trial
    Shrita M Patel
    Division of Endocrinology, Diabetes, and Metabolism, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Fertil Steril 94:2161-6. 2010
    ..To determine whether insulin sensitizers lower androgen levels and whether androgen suppression improves insulin resistance in nondiabetic postmenopausal women...
  20. ncbi Insulin sensitizing pharmacotherapy for prevention of myocardial infarction in patients with diabetes mellitus
    William H Sauer
    Cardiovascular Division, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania
    Am J Cardiol 97:651-4. 2006
    ....
  21. pmc Predictors of thyroid hormone initiation in older adults: results from the cardiovascular health study
    Lily L Somwaru
    Division of Endocrinology, Diabetes, and Metabolism, University of Pennsylvania School of Medicine, Philadelphia, USA
    J Gerontol A Biol Sci Med Sci 66:809-14. 2011
    ..Despite widespread use, there are no data on initiation of thyroid hormone use in older people. We report the prevalence of thyroid hormone use and predictors of thyroid hormone initiation in a population of older men and women...

Research Grants6

  1. Hormonal trajectories in aging
    Anne Cappola; Fiscal Year: 2007
    ..Our work will directly guide the selection of the appropriate population for growth hormone analogues and DHEA. ..
  2. Hormonal trajectories in aging
    Anne Cappola; Fiscal Year: 2009
    ..Our work will directly guide the selection of the appropriate population for growth hormone analogues and DHEA. ..
  3. Subclinical thyroid dysfunction in the elderly
    Anne R Cappola; Fiscal Year: 2010
    ..Our findings will assess the anticipated risks and benefits of treatment using existing data, to refine the target population for a clinical trial. ..