Edmund V Capparelli

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Efficacy of noradrenergic and serotonergic antidepressants in chronic back pain: a preliminary concentration-controlled trial
    J Hampton Atkinson
    Department of Psychiatry, VA San Diego Healthcare System, San Diego, CA 92161, USA
    J Clin Psychopharmacol 27:135-42. 2007
  2. pmc Population pharmacokinetics of artesunate and dihydroartemisinin in pregnant and non-pregnant women with malaria
    Carrie A Morris
    University of Iowa, College of Pharmacy, 115 South Grand Avenue, Iowa City, IA 52242, USA
    Malar J 10:114. 2011
  3. pmc Pharmacokinetics and pharmacodynamics of artesunate and dihydroartemisinin following oral treatment in pregnant women with asymptomatic Plasmodium falciparum infections in Kinshasa DRC
    Marie A Onyamboko
    Kinshasa School of Public Health, Kinshasa, the Democratic Republic of Congo
    Malar J 10:49. 2011
  4. ncbi request reprint Lopinavir concentrations in cerebrospinal fluid exceed the 50% inhibitory concentration for HIV
    Edmund V Capparelli
    Pediatric Pharmacology Research Unit, University of California San Diego, La Jolla, California 92093 8214, USA
    AIDS 19:949-52. 2005
  5. pmc Chronic administration of nevirapine during pregnancy: impact of pregnancy on pharmacokinetics
    E V Capparelli
    San Diego Schools of Medicine and Pharmacy and Pharmaceutical Sciences, University of California, San Diego, CA 92103, USA
    HIV Med 9:214-20. 2008
  6. pmc Population pharmacokinetics of cefepime in the neonate
    Edmund Capparelli
    Pediatric Pharmacology Research Unit, University of California, 4094 4th Avenue, Suite 201, San Diego, California 92103, USA
    Antimicrob Agents Chemother 49:2760-6. 2005
  7. pmc Population pharmacokinetics of abacavir in plasma and cerebrospinal fluid
    Edmund V Capparelli
    Pediatric Pharmacology Research Unit PPRU, University of California, San Diego, 200 West Arbor Drive, MC 8214, San Diego, CA 92103 8214, USA
    Antimicrob Agents Chemother 49:2504-6. 2005
  8. pmc Pharmacokinetics of gatifloxacin in infants and children
    Edmund V Capparelli
    Pediatric Pharmacology Research Unit, University of California, San Diego, California, USA
    Antimicrob Agents Chemother 49:1106-12. 2005
  9. ncbi request reprint Pharmacotherapy of perinatal HIV
    Edmund Capparelli
    University of California, San Diego, Pediatric Pharmacology Research Unit, 4094 Fourth Street 201, San Diego, CA 92103, USA
    Semin Fetal Neonatal Med 10:161-75. 2005
  10. ncbi request reprint Pharmacokinetics and tolerance of zidovudine in preterm infants
    Edmund V Capparelli
    University of California, San Diego, USA
    J Pediatr 142:47-52. 2003

Research Grants

  1. Pediatric Pharmacology Research Unit Network
    Edmund Capparelli; Fiscal Year: 2007

Detail Information

Publications70

  1. ncbi request reprint Efficacy of noradrenergic and serotonergic antidepressants in chronic back pain: a preliminary concentration-controlled trial
    J Hampton Atkinson
    Department of Psychiatry, VA San Diego Healthcare System, San Diego, CA 92161, USA
    J Clin Psychopharmacol 27:135-42. 2007
    ....
  2. pmc Population pharmacokinetics of artesunate and dihydroartemisinin in pregnant and non-pregnant women with malaria
    Carrie A Morris
    University of Iowa, College of Pharmacy, 115 South Grand Avenue, Iowa City, IA 52242, USA
    Malar J 10:114. 2011
    ..In this analysis, the population pharmacokinetics of oral AS, and its active metabolite dihydroartemisinin (DHA), were studied in pregnant and non-pregnant women at the Kingasani Maternity Clinic in the DRC...
  3. pmc Pharmacokinetics and pharmacodynamics of artesunate and dihydroartemisinin following oral treatment in pregnant women with asymptomatic Plasmodium falciparum infections in Kinshasa DRC
    Marie A Onyamboko
    Kinshasa School of Public Health, Kinshasa, the Democratic Republic of Congo
    Malar J 10:49. 2011
    ..Artemisinin-based IPT regimens represent a promising potential alternative to SP. Pharmacokinetic and safety data supporting the use of artemisinin derivatives in pregnancy are urgently needed...
  4. ncbi request reprint Lopinavir concentrations in cerebrospinal fluid exceed the 50% inhibitory concentration for HIV
    Edmund V Capparelli
    Pediatric Pharmacology Research Unit, University of California San Diego, La Jolla, California 92093 8214, USA
    AIDS 19:949-52. 2005
    ..However, even low lopinavir concentrations may be sufficient to inhibit HIV replication. Prior anecdotal reports indicated that lopinavir concentrations were below detection in cerebrospinal fluid (CSF)...
  5. pmc Chronic administration of nevirapine during pregnancy: impact of pregnancy on pharmacokinetics
    E V Capparelli
    San Diego Schools of Medicine and Pharmacy and Pharmaceutical Sciences, University of California, San Diego, CA 92103, USA
    HIV Med 9:214-20. 2008
    ..To determine the impact of pregnancy on the pharmacokinetics (PK) of nevirapine (NVP) during chronic dosing in HIV-infected women and appropriate NVP dosing in this population...
  6. pmc Population pharmacokinetics of cefepime in the neonate
    Edmund Capparelli
    Pediatric Pharmacology Research Unit, University of California, 4094 4th Avenue, Suite 201, San Diego, California 92103, USA
    Antimicrob Agents Chemother 49:2760-6. 2005
    ..Cefepime, dosed at 30 mg/kg/dose every 12 h for infants less than 14 days of age, regardless of gestational age, should provide antibiotic exposure equivalent to or greater than 50 mg/kg every 8 h in older infants and children...
  7. pmc Population pharmacokinetics of abacavir in plasma and cerebrospinal fluid
    Edmund V Capparelli
    Pediatric Pharmacology Research Unit PPRU, University of California, San Diego, 200 West Arbor Drive, MC 8214, San Diego, CA 92103 8214, USA
    Antimicrob Agents Chemother 49:2504-6. 2005
    ..The abacavir CSF/plasma ratio averaged 36% and increased throughout the dose interval. Abacavir penetrates into the CSF in adequate concentrations to inhibit local human immunodeficiency virus replication...
  8. pmc Pharmacokinetics of gatifloxacin in infants and children
    Edmund V Capparelli
    Pediatric Pharmacology Research Unit, University of California, San Diego, California, USA
    Antimicrob Agents Chemother 49:1106-12. 2005
    ..h/ml (estimated free AUC/MIC ratio of > or =34 for MIC of < or =0.5 microg/ml). These data suggest that gatifloxacin at a dose of 10 mg/kg every 24 h will achieve therapeutic concentrations in plasma in infants and children...
  9. ncbi request reprint Pharmacotherapy of perinatal HIV
    Edmund Capparelli
    University of California, San Diego, Pediatric Pharmacology Research Unit, 4094 Fourth Street 201, San Diego, CA 92103, USA
    Semin Fetal Neonatal Med 10:161-75. 2005
    ..Although difficult to perform, clinical trials to determine the safety, pharmacokinetics and optimal dosing of antiretroviral in pregnant women and their newborns are urgently needed...
  10. ncbi request reprint Pharmacokinetics and tolerance of zidovudine in preterm infants
    Edmund V Capparelli
    University of California, San Diego, USA
    J Pediatr 142:47-52. 2003
    ..To determine zidovudine pharmacokinetics and tolerance in premature human human immunodeficiency virus-exposed infants...
  11. pmc Lopinavir tablet pharmacokinetics with an increased dose during pregnancy
    Brookie M Best
    Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, San Diego, CA, USA
    J Acquir Immune Defic Syndr 54:381-8. 2010
    ..This study determined lopinavir exposure with an increased dose of the new tablet formulation during the third trimester...
  12. pmc Developmental pharmacokinetic changes of Lamivudine in infants and children
    Adriana H Tremoulet
    UC San Diego Pediatric Research Center, 7910 Frost St, 360, San Diego, CA 92123, USA
    J Clin Pharmacol 52:1824-32. 2012
    ..Lamivudine WHO weight band dosing results in therapeutic exposure in infants and children and may improve drug dosing in resource-limited countries...
  13. pmc Low cerebrospinal fluid concentrations of the nucleotide HIV reverse transcriptase inhibitor, tenofovir
    Brookie M Best
    Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, CA 92093 0719, USA
    J Acquir Immune Defic Syndr 59:376-81. 2012
    ..The study's objective was to determine tenofovir's penetration into cerebrospinal fluid (CSF)...
  14. pmc Population pharmacokinetics of lamivudine in human immunodeficiency virus-exposed and -infected infants
    Adriana H Tremoulet
    Division of Pharmacology and Drug Discovery, Pediatric Pharmacology Research Unit, University of California San Diego, MC 8214, San Diego, CA 92103 8214, USA
    Antimicrob Agents Chemother 51:4297-302. 2007
    ....
  15. pmc Efavirenz concentrations in CSF exceed IC50 for wild-type HIV
    Brookie M Best
    University of California San Diego, Skaggs School of Pharmacy and Pharmaceutical Sciences, San Diego, CA, USA
    J Antimicrob Chemother 66:354-7. 2011
    ..This study's objective was to determine penetration of a commonly prescribed antiretroviral drug, efavirenz, into CSF...
  16. pmc CYP2C19 genetic variants affect nelfinavir pharmacokinetics and virologic response in HIV-1-infected children receiving highly active antiretroviral therapy
    Akihiko Saitoh
    Division of Infectious Diseases, Department of Pediatrics, University of California, San Diego, La Jolla, CA, USA
    J Acquir Immune Defic Syndr 54:285-9. 2010
    ....
  17. ncbi request reprint A randomized controlled trial of therapeutic drug monitoring in treatment-naive and -experienced HIV-1-infected patients
    Brookie M Best
    University of California, San Diego, San Diego, CA 92013, USA
    J Acquir Immune Defic Syndr 46:433-42. 2007
    ..To improve the utility of therapeutic drug monitoring (TDM) by defining the proportion of patients with and predictors of above or below target protease inhibitor (PI) or nonnucleoside reverse transcriptase inhibitor (NNRTI) concentrations...
  18. ncbi request reprint Impact of pregnancy on abacavir pharmacokinetics
    Brookie M Best
    University of California San Diego, California 92103 8214, USA
    AIDS 20:553-60. 2006
    ..To describe abacavir pharmacokinetics during pregnancy and postpartum; physiological changes during pregnancy are known to affect antiretroviral drug disposition...
  19. pmc Methamphetamine use parameters do not predict neuropsychological impairment in currently abstinent dependent adults
    Mariana Cherner
    Department of Psychiatry, University of California San Diego School of Medicine, 9500 Gilman Drive, La Jolla, CA 92093 0847, USA
    Drug Alcohol Depend 106:154-63. 2010
    ..The apparent lack of correspondence between substance use parameters and cognitive impairment suggests the need for further study of individual differences in vulnerability to the neurotoxic effects of methamphetamine...
  20. pmc Low atazanavir concentrations in cerebrospinal fluid
    Brookie M Best
    Skaggs School of Pharmacy andPharmaceutical Sciences, School of Medicine, Department of Pediatrics, University of California, San Diego, 9500 Gilman Drive, MC 0719, La Jolla, CA 92093 0719, USA
    AIDS 23:83-7. 2009
    ..The objective of this study was to determine atazanavir penetration into cerebrospinal fluid (CSF)...
  21. pmc Variable patterns of neuropsychological performance in HIV-1 infection
    S Dawes
    Department of Psychiatry, HIV Neurobehavioral Research Center, University of California San Diego, San Diego, CA 92093 0603, USA
    J Clin Exp Neuropsychol 30:613-26. 2008
    ..Thus, there does not appear to be a single, prototypical pattern of neuropsychological impairment associated with HIV infection for this battery of representative neuropsychological tests...
  22. pmc Lopinavir protein binding in HIV-1-infected pregnant women
    F T Aweeka
    Drug Research Unit, University of California, San Francisco, CA 94143 0622, USA
    HIV Med 11:232-8. 2010
    ..We report lopinavir (LPV) PB during third trimester (antepartum, AP) compared to > or =1.7 weeks postpartum (PP) to determine if FU changes compensate for reduced total concentrations reported previously...
  23. pmc Improved vancomycin dosing in children using area under the curve exposure
    Jennifer Le
    Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, CA 92093 0714, USA
    Pediatr Infect Dis J 32:e155-63. 2013
    ....
  24. pmc Nevirapine exposure with WHO pediatric weight band dosing: enhanced therapeutic concentrations predicted based on extensive international pharmacokinetic experience
    Mina Nikanjam
    University of California San Diego, La Jolla, California, USA
    Antimicrob Agents Chemother 56:5374-80. 2012
    ..Weight band dosing of NVP proposed by the WHO has the potential to provide a simple and effective dosing strategy for resource limited settings...
  25. pmc Infliximab treatment of intravenous immunoglobulin-resistant Kawasaki disease
    Jane C Burns
    Department of Pediatrics, University of California San Diego School of Medicine and Rady Children s Hospital San Diego, La Jolla, CA, USA
    J Pediatr 153:833-8. 2008
    ..To investigate the safety, tolerability, and pharmacokinetics of the anti-tumor necrosis factor-alpha monoclonal antibody infliximab in subjects with intravenous immunoglobulin (IVIG)-resistant Kawasaki disease (KD)...
  26. pmc Pharmacokinetics of lopinavir/ritonavir crushed versus whole tablets in children
    Brookie M Best
    Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA 92093 0719, USA
    J Acquir Immune Defic Syndr 58:385-91. 2011
    ..In clinical practice, Kaletra tablets are occasionally crushed for pediatric administration. This study compared lopinavir/ritonavir exposure between whole and crushed tablets in HIV-infected children...
  27. pmc White matter tract injury and cognitive impairment in human immunodeficiency virus-infected individuals
    Assawin Gongvatana
    San Diego State University University of California, San Diego, Joint Doctoral Program in Clinical Psychology, San Diego and La Jolla, California, USA
    J Neurovirol 15:187-95. 2009
    ..The study also confirms that CNS injury is evident in persons infected with HIV despite effective antiretroviral treatment...
  28. pmc Negative mood and sexual behavior among non-monogamous men who have sex with men in the context of methamphetamine and HIV
    C A Bousman
    University of California San Diego, HIV Neurobehavioral Research Center, Department of Psychiatry, La Jolla, California 92103, USA
    J Affect Disord 119:84-91. 2009
    ..This study examined the contextual influence of METH, HIV-infection and their combination on mood states and sexual behavior...
  29. doi request reprint Meropenem pharmacokinetics, pharmacodynamics, and Monte Carlo simulation in the neonate
    John S Bradley
    Division of Infectious Diseases, Children s Hospital and Health Center, San Diego, CA 92123, USA
    Pediatr Infect Dis J 27:794-9. 2008
    ..Hospitalized neonates are exposed to antibiotic-resistant bacterial pathogens and develop nosocomial infections. Limited data are available regarding the neonatal pharmacokinetics of meropenem, a broad spectrum carbapenem antibiotic...
  30. ncbi request reprint Population pharmacokinetics and pharmacodynamics of zidovudine in HIV-infected infants and children
    Edmund V Capparelli
    University of California, San Diego, School of Medicine, La Jolla, California, USA
    J Clin Pharmacol 43:133-40. 2003
    ..It was concluded that ZDV oral clearance is reduced in infants compared to older children. This lower clearance leads to higher ZDV exposure in infants and contributes to increased hematologic toxicity...
  31. ncbi request reprint The correlation between plasma concentrations of protease inhibitors, medication adherence and virological outcome in HIV-infected patients
    Julie M Yasuda
    San Diego State University, San Diego, Calif, USA
    Antivir Ther 9:753-61. 2004
    ..The objective of this analysis was to assess the independent predictive value of protease inhibitor (PI) concentrations as a supplement to self-report as markers of medication adherence...
  32. pmc The semantic relatedness of cue-intention pairings influences event-based prospective memory failures in older adults with HIV infection
    Steven Paul Woods
    HIV Neurobehavioral Research Center, Department of Psychiatry, University of California, San Diego, CA 92103, USA
    J Clin Exp Neuropsychol 32:398-407. 2010
    ....
  33. pmc Longer term improvement in neurocognitive functioning and affective distress among methamphetamine users who achieve stable abstinence
    Jennifer E Iudicello
    Department of Psychiatry, HIV Neurobehavioral Research Center, University of California, San Diego, School of Medicine, La Jolla, CA 92103, USA
    J Clin Exp Neuropsychol 32:704-18. 2010
    ..These results suggest partial recovery of neuropsychological functioning and improvement in affective distress upon sustained abstinence from MA that may extend beyond a year or more...
  34. doi request reprint Continued high prevalence and adverse clinical impact of human immunodeficiency virus-associated sensory neuropathy in the era of combination antiretroviral therapy: the CHARTER Study
    Ronald J Ellis
    HIV Neurobehavioral Research Center, Department of Neurosciences, University of California, San Diego, San Diego, CA 92103, USA
    Arch Neurol 67:552-8. 2010
    ..To provide updated estimates of the prevalence and clinical impact of human immunodeficiency virus-associated sensory neuropathy (HIV-SN) and neuropathic pain due to HIV-SN in the combination antiretroviral therapy (CART) era...
  35. pmc Cytochrome P450-2D6 extensive metabolizers are more vulnerable to methamphetamine-associated neurocognitive impairment: preliminary findings
    Mariana Cherner
    Department of Psychiatry, University of California San Diego, La Jolla, California 92093 0847, USA
    J Int Neuropsychol Soc 16:890-901. 2010
    ..This preliminary study is the first to suggest that efficient meth metabolism is associated with worse neurocognitive outcomes in humans, and implicates the products of oxidative metabolism of meth as a possible source of brain injury...
  36. pmc Spontaneous strategy use protects against visual working memory deficits in older adults infected with HIV
    Steven Paul Woods
    Department of Psychiatry, University of California San Diego, La Jolla, USA
    Arch Clin Neuropsychol 25:724-33. 2010
    ....
  37. pmc Total raltegravir concentrations in cerebrospinal fluid exceed the 50-percent inhibitory concentration for wild-type HIV-1
    David Croteau
    HIV Neurobehavioral Research Center, University of California San Diego, 220 Dickinson, Suite B, 8208, San Diego, CA 92103, USA
    Antimicrob Agents Chemother 54:5156-60. 2010
    ..As a component of effective antiretroviral regimens or as the main antiretroviral, RAL likely contributes to the control of HIV replication in the nervous system...
  38. pmc HIV-associated neurocognitive disorders persist in the era of potent antiretroviral therapy: CHARTER Study
    R K Heaton
    University of California, San Diego, USA
    Neurology 75:2087-96. 2010
    ....
  39. pmc HIV-associated neurocognitive disorders before and during the era of combination antiretroviral therapy: differences in rates, nature, and predictors
    Robert K Heaton
    University of California, San Diego, CA, USA
    J Neurovirol 17:3-16. 2011
    ..Clinical trials targeting HAND prevention should specifically examine timing of ART initiation...
  40. ncbi request reprint Is there a therapeutic window with some antidepressants for analgesic response?
    J Hampton Atkinson
    VA San Diego Healthcare System, 3350 La Jolla Village Drive, 116A, San Diego, CA 92161, USA
    Curr Pain Headache Rep 13:93-9. 2009
    ..This article reviews the strengths, limitations, and potential of therapeutic drug monitoring of antidepressants and anticonvulsants as analgesics for selected chronic pain syndromes...
  41. ncbi request reprint A computer-based system to aid in the interpretation of plasma concentrations of antiretrovirals for therapeutic drug monitoring
    Miguel Goicoechea
    University of California San Diego, San Diego, CA, USA
    Antivir Ther 12:55-62. 2007
    ..To develop a computer-based system for modelling and interpreting plasma antiretroviral concentrations for therapeutic drug monitoring (TDM)...
  42. ncbi request reprint Failure of modified directly observed therapy combined with therapeutic drug monitoring to enhance antiretroviral adherence in a patient with major depression
    Miguel Goicoechea
    University California San Diego, School of Medicine, San Diego, California 92103, USA
    AIDS Patient Care STDS 20:233-7. 2006
    ..It should be recognized that not all patients are capable of achieving lifelong medication adherence and may benefit from continued supervised therapy...
  43. ncbi request reprint Meeting practical challenges of a trial involving a multitude of treatment regimens: an example of a multi-center randomized controlled clinical trial in neuroAIDS
    Susanne May
    Division of Biostatistics and Bioinformatics, Department of Family and Preventive Medicine, and Department of Neurosciences, University of California, San Diego, 9500 Gilman Drive M C 0717, La Jolla, CA 92093 0717, USA
    J Neuroimmune Pharmacol 2:97-104. 2007
    ..A small pilot study demonstrated the feasibility and acceptability to providers. In conclusion, an innovative design can provide solutions to challenging practical issues in trials with multiple treatment options...
  44. ncbi request reprint CYP2B6 genetic variants are associated with nevirapine pharmacokinetics and clinical response in HIV-1-infected children
    Akihiko Saitoh
    Division of Infectious Diseases, Department of Pediatrics, University of California, San Diego, La Jolla, California 92093 0672, USA
    AIDS 21:2191-9. 2007
    ....
  45. pmc Validation of the CNS Penetration-Effectiveness rank for quantifying antiretroviral penetration into the central nervous system
    Scott Letendre
    University of California, San Diego, 150 W Washington St, San Diego, CA 92103, USA
    Arch Neurol 65:65-70. 2008
    ..To evaluate whether penetration of a combination regimen into the central nervous system (CNS), as estimated by the CNS Penetration-Effectiveness (CPE) rank, is associated with lower cerebrospinal fluid (CSF) viral load...
  46. pmc Prospective memory in HIV infection: is "remembering to remember" a unique predictor of self-reported medication management?
    Steven Paul Woods
    Department of Psychiatry, HIV Neurobehavioral Research Center, University of California, San Diego, School of Medicine, La Jolla, CA 92093, USA
    Arch Clin Neuropsychol 23:257-70. 2008
    ..The potential benefits of individualized remediation strategies that are informed by conceptual models of ProM and specifically target medication adherence warrant further exploration...
  47. pmc Psychometric characteristics of the memory for intentions screening test
    Steven Paul Woods
    Department of Psychiatry, University of California, San Diego, CA, USA
    Clin Neuropsychol 22:864-78. 2008
    ..Recommendations are provided regarding future research to enhance the clinical usefulness of the MIST...
  48. ncbi request reprint A phase I study of AIT-082 in healthy elderly volunteers
    Michael Grundman
    Department of Neurosciences, University of California, San Diego, La Jolla 92037, USA
    J Mol Neurosci 18:283-93. 2002
    ..In conclusion, AIT-082 was rapidly absorbed by the oral route with a half-life suitable for once daily dosing. No problems with tolerability or safety were demonstrated...
  49. pmc Pleocytosis is associated with disruption of HIV compartmentalization between blood and cerebral spinal fluid viral populations
    Davey M Smith
    University of California San Diego, La Jolla, 92093, USA
    Virology 385:204-8. 2009
    ....
  50. doi request reprint Determination of efavirenz in human dried blood spots by reversed-phase high-performance liquid chromatography with UV detection
    Justin T Hoffman
    Skagg s School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, San Diego, CA 92093 0831, USA
    Ther Drug Monit 35:203-8. 2013
    ....
  51. doi request reprint Rapid weight gain in children soon after diagnosis of type 1 diabetes: is there room for concern?
    Ron S Newfield
    Division of Pediatric Endocrinology, Department of Pediatrics, Rady Children s Hospital San Diego, San Diego, CA, USA
    Pediatr Diabetes 10:310-5. 2009
    ..All patients received two daily insulin injections (NPH/Regular) and were examined at least twice, up to 7 months post-Dx...
  52. pmc Differential expression of immunophilins FKBP51 and FKBP52 in the frontal cortex of HIV-infected patients with major depressive disorder
    Erick T Tatro
    Department of Psychiatry 0603, University of California at San Diego, La Jolla, San Diego, CA 92093 0603, USA
    J Neuroimmune Pharmacol 4:218-26. 2009
    ..Instead, an increase in FKBP51 at both the transcript (FKBP5) and protein level correlated with MDD. Increased FKBP4 expression of correlated to HIV(+)MDD but not to HIV without MDD...
  53. pmc Implications of hepatitis C virus infection for behavioral symptoms and activities of daily living
    Carolina Posada
    San Diego State University University of California, San Diego Joint Doctoral Program in Clinical Psychology, San Diego, CA, USA
    J Clin Exp Neuropsychol 32:637-44. 2010
    ..These results show that a subset of HCV-infected individuals report clinically elevated behavioral symptoms. Clinical implications for the assessment and management of elevated behavioral symptoms in HCV are discussed...
  54. doi request reprint Omeprazole limited sampling strategies to predict area under the concentration-time curve ratios: implications for cytochrome P450 2C19 and 3A phenotyping
    Eileen B Lawson
    Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego UCSD, 9500 Gilman Drive, MC 0714, La Jolla, CA 92093 0714, USA
    Eur J Clin Pharmacol 68:407-13. 2012
    ....
  55. pmc Implications of gender and pregnancy for antiretroviral drug dosing
    Brookie M Best
    University of California, San Diego, Skaggs School of Pharmacy and Pharmaceutical Sciences, and the Department of Pediatrics, School of Medicine, San Diego, California, USA
    Curr Opin HIV AIDS 3:277-82. 2008
    ..The correct dose is critical to maintain efficacy and safety of these agents for both the mother and the fetus. Innovative study designs are needed to facilitate the study of antiretrovirals during pregnancy...
  56. pmc Multicenter study to determine antibody concentrations and assess the safety of administration of INH-A21, a donor-selected human Staphylococcal immune globulin, in low-birth-weight infants
    Edmund V Capparelli
    Trials by Design LLC, San Diego, California, USA
    Antimicrob Agents Chemother 49:4121-7. 2005
    ..Further studies examining INH-A21 for the prevention of late-onset sepsis in infants within the weight range studied are warranted...
  57. doi request reprint Increased frequency of alpha-synuclein in the substantia nigra in human immunodeficiency virus infection
    Negar Khanlou
    Department of Pathology and Laboratory Medicine, Division of Neuropathology, David Geffen School of Medicine, Ronald Reagan UCLA Medical Center, Los Angeles, California, USA
    J Neurovirol 15:131-8. 2009
    ..The increased prevalence of alpha-synuclein and beta-amyloid in the brains of older HIV-infected individuals may predict an increased risk of developing neurodegenerative disease...
  58. pmc Increased accumulation of intraneuronal amyloid beta in HIV-infected patients
    Cristian L Achim
    Department of Psychiatry, University of California, San Diego, CA 92093 0624, USA
    J Neuroimmune Pharmacol 4:190-9. 2009
    ..These findings suggest that long-term survival with HIV might interfere with clearance of proteins such as Abeta and worsen neuronal damage and cognitive impairment in this population...
  59. doi request reprint Pharmacology and tolerability of a single dose of exenatide in adolescent patients with type 2 diabetes mellitus being treated with metformin: a randomized, placebo-controlled, single-blind, dose-escalation, crossover study
    Jaret Malloy
    Amylin Pharmaceuticals, Inc, San Diego, California 92121, USA
    Clin Ther 31:806-15. 2009
    ..This study assessed the pharmacokinetics, pharmacodynamics, and tolerability of single doses of exenatide in adolescent patients with type 2 diabetes mellitus (T2DM)...
  60. ncbi request reprint Nevirapine concentration in nonstimulated saliva: an alternative to plasma sampling in children with human immunodeficiency virus infection
    Natella Y Rakhmanina
    Division of Infectious Disease, The George Washington University School of Medicine, Washington, DC 20010, USA
    Ther Drug Monit 29:110-7. 2007
    ....
  61. pmc Pharmacokinetics of high-dose lopinavir-ritonavir with and without saquinavir or nonnucleoside reverse transcriptase inhibitors in human immunodeficiency virus-infected pediatric and adolescent patients previously treated with protease inhibitors
    Brian L Robbins
    St Jude Children s Research Hospital, Memphis, Tennessee, USA
    Antimicrob Agents Chemother 52:3276-83. 2008
    ....
  62. ncbi request reprint Instability of lopinavir/ritonavir capsules at ambient temperatures in sub-Saharan Africa: relevance to WHO antiretroviral guidelines
    Alice K Pau
    National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
    AIDS 19:1233-4. 2005
    ..Although maintaining chemical stability for 4 weeks at 35 degrees C, at 45 degrees C the capsules clumped after 7 days, supporting a need for more temperature-stable formulations for hotter climates...
  63. ncbi request reprint Pharmacokinetics, safety and efficacy of lopinavir/ritonavir in infants less than 6 months of age: 24 week results
    Ellen G Chadwick
    Department of Pediatrics, Northwestern University, Feinberg School of Medicine, Chicago, Illinois, USA
    AIDS 22:249-55. 2008
    ..To investigate pharmacokinetics, safety and efficacy of lopinavir/ritonavir (LPV/r)-based therapy in HIV-1-infected infants 6 weeks to 6 months of age...
  64. ncbi request reprint Double blind placebo-controlled trial of pleconaril in infants with enterovirus meningitis
    Mark J Abzug
    Pediatric Infectious Disease, Department of Pediatrics, University of Colorado School of Medicine and The Children s Hospital, 1056 E Nineteenth Avenue, Denver, CO 80218, USA
    Pediatr Infect Dis J 22:335-41. 2003
    ..Treatment of older children and adults with pleconaril has been associated with reduced severity and duration of symptoms. This study evaluated the pharmacokinetics, safety and efficacy of pleconaril in infants with EV meningitis...
  65. ncbi request reprint Model appropriateness and population pharmacokinetic modeling
    Ene I Ette
    Vertex Pharmaceutical, Inc, Cambridge, Massachusetts, USA
    J Clin Pharmacol 43:610-23. 2003
    ..Model appropriateness was efficiently established and determined to address the problem of comparing competing dosing strategies...
  66. ncbi request reprint Single- and multiple-dose pharmacokinetics of pioglitazone in adolescents with type 2 diabetes
    Michael L Christensen
    University of Tennessee, 50 North Dunlap, Room 306, Memphis, TN 38103, USA
    J Clin Pharmacol 45:1137-44. 2005
    ..5- to 3.0-fold for M-III and M-IV. The sustained total serum concentration of active compounds during multiple dosing provides the basis for once-daily dose administration of pioglitazone in adolescents...
  67. ncbi request reprint UGT2B7 promoter variant -840G>A contributes to the variability in hepatic clearance of morphine in patients with sickle cell disease
    Deepika S Darbari
    Center for Cancer and Blood Disorders, Children s National Medical Center, Washington, DC 20010, USA
    Am J Hematol 83:200-2. 2008
    ..1 +/- 2.7 vs. 15.7 +/- 9.4 for M3G/M) (P = 0.03). Presence of UGT2B7 -840G allele is associated with significantly reduced glucuronidation of morphine and thus contributes to the variability in hepatic clearance of morphine in SCD...
  68. ncbi request reprint Summary proceedings from the neonatal pain-control group
    Kanwaljeet J S Anand
    Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA
    Pediatrics 117:S9-S22. 2006
    ..Full-length articles on procedural pain, sedation and analgesia for ventilated infants, perioperative pain, and study designs for neonatal pain research were published in Clinical Therapeutics (June 2005)...
  69. pmc Population pharmacokinetic model for gatifloxacin in pediatric patients
    Christopher M Rubino
    Cognigen Corporation, Buffalo, NY, USA
    Antimicrob Agents Chemother 51:1246-52. 2007
    ..The success of this strategy provides a model for future pediatric drug development programs...
  70. ncbi request reprint Pharmacokinetics of dexmedetomidine in postsurgical pediatric intensive care unit patients: preliminary study
    Susan M Diaz
    Rady Children s Hospital and Health Center and Presbyterian Healthcare Services, Albuquerque, NM 87125, USA
    Pediatr Crit Care Med 8:419-24. 2007
    ....

Research Grants3

  1. Pediatric Pharmacology Research Unit Network
    Edmund Capparelli; Fiscal Year: 2007
    ..5. To apply pharmacogenomic and proteonomic tools in clinical studies. 6. To provide a training and educational program in clinical and developmental pharmacology. ..