Research Topics
| R CaplanSummaryAffiliation: University of California Country: USA Publications
Research Grants
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Detail Information
Publications
Medial temporal lobe in childhood-onset schizophreniaJ G Levitt
Department of Psychiatry, UCLA Neuropsychiatric Institute, 760 Westwood Plaza, Los Angeles, CA 90024, USA
Psychiatry Res 108:17-27. 2001..These findings are consistent with previous reports of at least initial sparing of temporal lobe regions in childhood-onset schizophrenia...- 10-year research update review: psychiatric problems in children with epilepsySigita Plioplys
Department of Child and Adolescent Psychiatry, Children s Memorial Hospital, Chicago, IL 60614, USA
J Am Acad Child Adolesc Psychiatry 46:1389-402. 2007..To critically review literature published from 1996 to 2007 on psychopathology in children with epilepsy (CWE)... - Multidisciplinary management of pediatric nonepileptic seizuresSigita Plioplys
Department of Psychiatry and Behavioral Sciences at Feinberg School of Medicine, Northwestern University, Children's Memorial Hospital, Chicago, IL 60614, USA
J Am Acad Child Adolesc Psychiatry 46:1491-5. 2007 - Psychiatric disorders in children and adolescents who have epilepsyJana E Jones
Department of Neurology, University of Wisconsin School of Medicine and Public Health, Madison, USA
Pediatr Rev 29:e9-14. 2008 
Formal thought disorder and the autism spectrum: relationship with symptoms, executive control, and anxietyMarjorie Solomon
Department of Psychiatry and Behavioral Sciences, University of California, Davis, 2230 Stockton Blvd, Sacramento, CA, 95817, USA
J Autism Dev Disord 38:1474-84. 2008..When FTD is present in ASDs, it generally is not a co-morbid schizophrenia symptom, but is related to pragmatic language abnormalities found in ASDs. The clinical and neurobiological significance of this work is discussed...- Suicidality and brain volumes in pediatric epilepsyRochelle Caplan
Department of Psychiatry, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA, USA
Epilepsy Behav 18:286-90. 2010..Given the role of the orbital frontal gyrus in both emotional regulation and epilepsy, these findings highlight the biological underpinnings of suicidal ideation in pediatric epilepsy... - Social competence in pediatric epilepsy: insights into underlying mechanismsRochelle Caplan
Department of Psychiatry, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA, USA
Epilepsy Behav 6:218-28. 2005.... - Depression and anxiety disorders in pediatric epilepsyRochelle Caplan
Department of Psychiatry, University of California at Los Angeles, 90024, USA
Epilepsia 46:720-30. 2005..This study examined affective disorders, anxiety disorders, and suicidality in children with epilepsy and their association with seizure-related, cognitive, linguistic, family history, social competence, and demographic variables... - Thought disorder: A developmental disability in pediatric epilepsyRochelle Caplan
Department of Psychiatry, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA, USA
Epilepsy Behav 8:726-35. 2006..The relationship of thought disorder to behavioral, academic, and social problems implies that these discourse deficits are one component of the developmental disabilities or comorbidities associated with pediatric CPS and PGE... - Frontal and temporal volumes in Childhood Absence EpilepsyRochelle Caplan
UCLA David Geffen School of Medicine, Department of Psychiatry, California, USA
Epilepsia 50:2466-72. 2009..It also examined the association of these volumes with seizure, demographic, perinatal, intelligence quotient (IQ), and psychopathology variables... - Childhood absence epilepsy: behavioral, cognitive, and linguistic comorbiditiesRochelle Caplan
Department of Psychiatry, University of California at Los Angeles, Los Angeles, California, USA
Epilepsia 49:1838-46. 2008..This cross-sectional study examined behavioral/emotional, cognitive, and linguistic comorbidities as well as their correlates in children with CAE... 
Thought disorder and frontotemporal volumes in pediatric epilepsyRochelle Caplan
Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA, USA
Epilepsy Behav 13:593-9. 2008..These findings suggest that thought disorder might represent a developmental disability involving frontotemporal regions associated with language in pediatric CPS...- Language in pediatric epilepsyRochelle Caplan
Department of Psychiatry, UCLA, Los Angeles, California, USA
Epilepsia 50:2397-407. 2009.... - Language and brain volumes in children with epilepsyRochelle Caplan
Department of Psychiatry, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA, USA
Epilepsy Behav 17:402-7. 2010.... - Psychopathology and pediatric complex partial seizures: seizure-related, cognitive, and linguistic variablesRochelle Caplan
Department of Psychiatry, University of California at Los Angeles, Los Angeles, California, USA
Epilepsia 45:1273-81. 2004..This study examined the role of cognition, language, seizure-related, and demographic variables in the psychopathology of children with complex partial seizure disorder (CPS) of average intelligence... - Blink rate in pediatric complex partial seizure disorderR Caplan
UCLA, Los Angeles, CA, USA
J Child Psychol Psychiatry 39:1145-52. 1998..Given previously reported low blink rates in schizophrenic children, these findings suggest that children with complex partial epilepsy or schizophrenia might have similar biological features... - Behavioral aspects of epilepsy in children with mental retardationR Caplan
Department of Psychiatry, University of California at Los Angeles, Los Angeles, California, USA
Ment Retard Dev Disabil Res Rev 6:293-9. 2000..Further studies are needed, however, to define better the interaction of these two conditions and how they impact the behavior of children... - Social communication in children with epilepsyRochelle Caplan
UCLA, USA
J Child Psychol Psychiatry 43:245-53. 2002..1-16.9 years... - Thought disorder in attention-deficit hyperactivity disorderR Caplan
Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, USA
J Am Acad Child Adolesc Psychiatry 40:965-72. 2001..This study compared thought disorder and associated cognitive variables in attention-deficit hyperactivity disorder (ADHD) and schizophrenia... - Conversational repair in pediatric epilepsyR Caplan
Department of Psychiatry, University of California, Los Angeles 90024, USA
Brain Lang 78:82-93. 2001..The CPS and PGE patients with frontal lobe involvement underused fillers compared to the normal children. These findings provide additional evidence that both CPS and PGE impact the ongoing development of children's communication skills... - Childhood schizophrenia: responsiveness to questions during conversationA Abu-Akel
University of California at Los Angeles, USA
J Am Acad Child Adolesc Psychiatry 39:779-86. 2000..It also ascertained the relationship of these speech functions with cognition and thought disorder... - Measures of psychopathology in children with complex partial seizures and primary generalized epilepsy with absenceD Ott
Neuropsychiatric Institute, Los Angeles, CA, 90024, USA
J Am Acad Child Adolesc Psychiatry 40:907-14. 2001.... - Brain abnormalities in early-onset schizophrenia spectrum disorder observed with statistical parametric mapping of structural magnetic resonance imagesE R Sowell
Laboratory of Neuro Imaging, University of California, Los Angeles, CA 90095 1769, USA
Am J Psychiatry 157:1475-84. 2000..Relatively few anatomical structures have been delineated and measured in this rare population, partly because of the labor involved in the slice-by-slice region definition required of conventional volumetric image analyses... - Language network dysfunction as a predictor of outcome in youth at clinical high risk for psychosisFred W Sabb
Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, Box 956968, Rm 2265, 300 Medical Plaza, Los Angeles, CA 90095 6968, USA
Schizophr Res 116:173-83. 2010..Yet, no study to date has investigated underlying neural networks associated with discourse processing in adolescents at clinical high risk (CHR) for developing psychosis(1)... - Amygdala volumes in childhood absence epilepsyAyelet Schreibman Cohen
Department of Psychiatry, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA
Epilepsy Behav 16:436-41. 2009.... - Detecting brain growth patterns in normal children using tensor-based morphometryXue Hua
Laboratory of Neuro Imaging, Brain Mapping Division, Department of Neurology, University of California Los Angeles School of Medicine, Los Angeles, CA 90095 7334, USA
Hum Brain Mapp 30:209-19. 2009..We demonstrate that a tensor-based Jacobian map is a sensitive and reliable method to detect regional tissue changes during development... - Amygdala volume and psychopathology in childhood complex partial seizuresMelita Daley
Department of Psychiatry, University of California Los Angeles, Los Angeles, CA 90095 1759, USA
Epilepsy Behav 13:212-7. 2008..The relationship of amygdala volume to seizure variables and presence of psychopathology was also examined in these patients... - Design considerations for a multicenter randomized controlled trial of early surgery for mesial temporal lobe epilepsyJerome Engel
Department of Neurology, UCLA, Los Angeles, California 90095 1769, USA
Epilepsia 51:1978-86. 2010..ERSET was designed to assess the safety and efficacy of early surgical intervention compared to continued pharmacotherapy... - Depression after status epilepticus: behavioural and biochemical deficits and effects of fluoxetineAndrey Mazarati
Department of Pediatrics, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 1752, USA
Brain 131:2071-83. 2008..The finding that behavioural equivalents of depression were resistant to an antidepressant medication suggested that depression in epilepsy might have distinct underlying mechanisms beyond alterations in serotonergic pathways... - Reduced white matter integrity in attention-deficit hyperactivity disorderLiberty S Hamilton
Laboratory of Neuro Imaging, UCLA Neuropsychiatric Institute and Hospital in Los Angeles, Geffen School of Medicine at UCLA, Los Angeles, California, USA
Neuroreport 19:1705-8. 2008..Results support that disruptions in motor and attentional networks may contribute toward ADHD pathophysiology. Future research may clarify how ADHD subtype and psychiatric comorbidities affect diffusion measures... - Frontal and temporal volumes in children with epilepsyMelita Daley
Department of Psychiatry, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA 90095 1759, USA
Epilepsy Behav 10:470-6. 2007..These findings highlight the need to control for seizure, cognitive, psychiatric, and demographic variables in studies of frontotemporal volumes in pediatric CPS... - Social difficulties in children with epilepsy: review and treatment recommendationsElena Harlan Drewel
Semel Institute for Neuroscience and Human Behavior, Department of Psychiatry and Biobehavioral Sciences, University of California at Los Angeles, CA, USA
Expert Rev Neurother 7:865-73. 2007..Recommendations for future research on social difficulties in children with epilepsy are discussed... - A functional magnetic resonance imaging study of discourse coherence in typically developing childrenMirella Dapretto
Ahmanson Lovelace Brain Mapping Center, University of California at Los Angeles, 90095, USA
Neuroreport 16:1661-5. 2005.... - Hippocampal volume in childhood complex partial seizuresMelita Daley
UCLA Department of Psychiatry, Psychiatry and Biobehavioral Sciences, UCLA, Semel Institute, Rm 48 253B, 760 Westwood Plaza, Los Angeles, CA 90095 1759, USA
Epilepsy Res 72:57-66. 2006..g., age, gender, ethnicity, socioeconomic status). It also examined the relationship between hippocampal volumes and seizure variables in the patients... - Abnormal development of the anterior cingulate in childhood-onset schizophrenia: a preliminary quantitative MRI studyRenée K Marquardt
Department of Psychiatry, UCLA Neuropsychiatric Institute, Los Angeles, CA 90024, USA
Psychiatry Res 138:221-33. 2005..These structural differences may relate to the well-described cognitive deficits these children display, and to the cardinal symptoms of schizophrenia... - Widespread cortical thinning is a robust anatomical marker for attention-deficit/hyperactivity disorderKatherine L Narr
David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA
J Am Acad Child Adolesc Psychiatry 48:1014-22. 2009.... - Case report: valproic Acid and risperidone treatment leading to development of hyperammonemia and maniaTeri Carlson
UCLA Semmel Institute of Neuroscience and Human Behavior, UCLA Medical Center, Los Angeles, CA 90024, USA
J Am Acad Child Adolesc Psychiatry 46:356-61. 2007..This case report alerts physicians to the importance of obtaining serum ammonia levels in children treated with valproic acid and risperidone who present with manic behavior... - 1H MRSI evidence of metabolic abnormalities in childhood-onset schizophreniaJOSEPH O'NEILL
Division of Child and Adolescent Psychiatry, University of California at Los Angeles, Los Angeles, CA 90095, USA
Neuroimage 21:1781-9. 2004..Low NAA may reflect diminished neuronal integrity... - Kindling epileptogenesis in immature rats leads to persistent depressive behaviorAndrey Mazarati
Department of Pediatrics, David Geffen School of Medicine at UCLA, Room 22 474 MDCC, Los Angeles, CA 90095 1752, USA
Epilepsy Behav 10:377-83. 2007..We conclude that neuronal plastic changes associated with the kindling state are accompanied by the development of depressive behavior... - Thought disorder and nucleus accumbens in childhood: a structural MRI studyMartina Ballmaier
Laboratory of Neuroimaging, Department of Neurology, UCLA School of Medicine, 710 Westwood Plaza, Los Angeles, CA 90095 1769, USA
Psychiatry Res 130:43-55. 2004.... - Behavioral disorders in pediatric epilepsy: unmet psychiatric needDerek Ott
Department of Psychiatry, University of California at Los Angeles, Los Angeles, California, USA
Epilepsia 44:591-7. 2003..This study examined the relation between psychiatric diagnosis and mental health services in children with epilepsy and the associated demographic, cognitive, linguistic, behavioral, and seizure-related variables... - Making sense during conversation: an fMRI studyR Caplan
Division of Child Psychiatry, Neuropsychiatric Institute, Rm. 48-253B, 760 Westwood Plaza, Los Angeles, CA 90095, USA
Neuroreport 12:3625-32. 2001..Thus, right and left hemisphere systems contribute uniquely to the linguistic skills involved in making sense of a conversation... - Obstacles to mental health care in pediatric epilepsy: insight from parentsPamela Vona
Department of Psychiatry, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA 90095 1759, USA
Epilepsy Behav 14:360-6. 2009..However, the study's findings suggested a need to determine if there are specific obstacles to MHC in pediatric epilepsy... - Superior temporal gyrus differences in childhood-onset schizophreniaJanelle L Taylor
Laboratory of Neuro Imaging, Deptartment of Neurology, Division of Brain Mapping, UCLA School of Medicine, 710 Westwood Plaza, Los Angeles, CA 90095-1769, USA
Schizophr Res 73:235-41. 2005..Our findings are consistent with studies that have found increased volumes in temporal lobe regions in COS and may provide a possible neural correlate for the language impairment observed in COS patients... - Unmet mental health needs in pediatric epilepsy: insights from providersKimberly Smith
Department of Psychiatry, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA, USA
Epilepsy Behav 11:401-8. 2007.... - Developmental outcome with and without successful interventionRochelle Caplan
Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, California 90095, USA
Int Rev Neurobiol 49:269-84. 2002..Finally, the underlying pathology of the resected brain, rather than ongoing seizures and seizure type, plays an important role in development of the remaining brain tissue and the outcome of early onset symptomatic IS and non-IS... - Consensus statement: the evaluation and treatment of people with epilepsy and affective disordersJohn J Barry
Department of Psychiatry and Behavioral Sciences, Stanford University Medical Center, Stanford, CA, USA
Epilepsy Behav 13:S1-29. 2008..Recommendations are based on the general depression literature as well as epilepsy-specific studies. It is hoped that this document will improve the overall detection and subsequent treatment of affective illnesses in PWE... - Dealing with epilepsy: parents speak upKeng Nei Wu
Semel Institute for Neuroscience and Human Behavior, University of California at Los Angeles, Los Angeles, CA, USA
Epilepsy Behav 13:131-8. 2008..They also underscore the importance of educating parents, service providers, and the general public about epilepsy... - A controlled study of formal thought disorder in children with autism and multiple complex developmental disordersRutger J van der Gaag
University Medical Centre St Radboud Nijmegen Academic Centre for Child and Adolescent Psychiatry, Nijmegen, The Netherlands
J Child Adolesc Psychopharmacol 15:465-76. 2005.... - Psychiatric comorbidity in children with new onset epilepsyJana E Jones
Department of Neurology, University of Wisconsin School of Medicine and Public Health, 600 N Highland, Madison, WI 53742, USA
Dev Med Child Neurol 49:493-7. 2007..The increased prevalence of psychiatric comorbidity antedating epilepsy onset may be consistent with the presence of underlying neurobiological influences independent of seizures, epilepsy syndrome, and medication treatment... - Behavioral and psychiatric comorbidities in pediatric epilepsy: toward an integrative modelJoan K Austin
Indiana University School of Nursing, Indianapolis, Indiana 46202 5107, USA
Epilepsia 48:1639-51. 2007..After the literature on each category is reviewed, an integrated heuristic model that includes key illness-related and psychosocial variables is presented... - Nonepileptic seizures treatment workshop summaryW Curt LaFrance
Brown Medical School, Department of Neurology, Rhode Island Hospital, 593 Eddy Street, Providence, RI 02903, USA
Epilepsy Behav 8:451-61. 2006..Various projects have resulted from the workshop, including the initial development of a prospective randomized clinical trial for NES...
Research Grants
- SURGERY FOR INFANTILE SPASMS CORRELATES OF AUTISTIC DISORDERRochelle Caplan; Fiscal Year: 2002..To apply the technique of neural networks to develop reliable and automated measures of neural structures relevant to schizophrenia 7. To examine the relationship between CCTCC abnormalities, symptom patterns, and cognitive performance ..
- THOUGHT DISORDER: A DEVELOPMENTAL DISABILITY IN EPILEPSYRochelle Caplan; Fiscal Year: 2003..Weekly seizure frequency data will be obtained on a monthly basis from the parent during the 2 years. ..
- Pediatric Thought Disorder: Insights from NeuroimagingRochelle Caplan; Fiscal Year: 2006..abstract_text> ..