Pascual García P, Jeong J, Capelson M. Nucleoporin Nup98 associates with Trx/MLL and NSL histone-modifying complexes and regulates Hox gene expression. Cell Rep. 2014;9:433-42 pubmed publisher
..These findings introduce roles of Nup98 in epigenetic regulation that may underlie the basis of oncogenicity of Nup98 fusions in leukemia. ..
Gozalo A, Capelson M. A New Path through the Nuclear Pore. Cell. 2016;167:1159-1160 pubmed publisher
..Now, Fernandez-Martinez et al. present a high-resolution structure of the cytoplasmic nuclear pore-mRNA export holo-complex, challenging our textbook depiction of this massive membrane-embedded complex. ..
Pascual García P, Debo B, Aleman J, Talamas J, Lan Y, Nguyen N, et al. Metazoan Nuclear Pores Provide a Scaffold for Poised Genes and Mediate Induced Enhancer-Promoter Contacts. Mol Cell. 2017;66:63-76.e6 pubmed publisher
..Together, our data identify Nups as a class of architectural proteins for enhancers and supports a model in which animal genomes use the nuclear pore as an organizing scaffold for inducible poised genes. ..