Sharon Cantor

Summary

Affiliation: University of Massachusetts Medical School
Country: USA

Publications

  1. pmc FANCJ/BACH1 acetylation at lysine 1249 regulates the DNA damage response
    Jenny Xie
    Department of Cancer Biology, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America
    PLoS Genet 8:e1002786. 2012
  2. pmc Hereditary breast cancer and the BRCA1-associated FANCJ/BACH1/BRIP1
    Sharon B Cantor
    Department of Cancer Biology, University of Massachusetts Medical School, 364 Plantation St, Worcester, MA 01605, USA
    Future Oncol 7:253-61. 2011
  3. doi request reprint Assessing the link between BACH1/FANCJ and MLH1 in DNA crosslink repair
    Sharon B Cantor
    Department of Cancer Biology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Environ Mol Mutagen 51:500-7. 2010
  4. ncbi request reprint Assessing the link between BACH1 and BRCA1 in the FA pathway
    Sharon B Cantor
    Department of Cancer Biology, University of Massachusetts Medical School, Women s Cancers Program, UMASS Memorial Cancer Center, Worcester, Massachusetts 01605, USA
    Cell Cycle 5:164-7. 2006
  5. pmc BRCA-FA pathway as a target for anti-tumor drugs
    Rachel Litman
    Department of Cancer Biology, University of Massachusetts Medical School, 364 Plantation St, Worcester, MA 01605, USA
    Anticancer Agents Med Chem 8:426-30. 2008
  6. pmc The FANCJ/MutLalpha interaction is required for correction of the cross-link response in FA-J cells
    Min Peng
    Department of Cancer Biology, University of Massachusetts Medical School Women s Cancers Program, UMASS Memorial Cancer Center, Worcester, MA, USA
    EMBO J 26:3238-49. 2007
  7. pmc The BRCA1-associated protein BACH1 is a DNA helicase targeted by clinically relevant inactivating mutations
    Sharon Cantor
    Department of Cancer Biology, University of Massachusetts Medical School, Lazare Research Building, Worcester, MA 01605, USA
    Proc Natl Acad Sci U S A 101:2357-62. 2004
  8. ncbi request reprint BACH1 is critical for homologous recombination and appears to be the Fanconi anemia gene product FANCJ
    Rachel Litman
    Department of Cancer Biology, University of Massachusetts Medical School, Worcester, 01605, USA
    Cancer Cell 8:255-65. 2005
  9. pmc FANCJ (BACH1) helicase forms DNA damage inducible foci with replication protein A and interacts physically and functionally with the single-stranded DNA-binding protein
    Rigu Gupta
    Laboratory of Molecular Gerontology, National Institute on Aging NIA, National Institutes of Health NIH, Baltimore, MD 21224, USA
    Blood 110:2390-8. 2007
  10. pmc Multifactorial contributions to an acute DNA damage response by BRCA1/BARD1-containing complexes
    Roger A Greenberg
    Department of Genetics, Harvard Medical School and the Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
    Genes Dev 20:34-46. 2006

Research Grants

Collaborators

  • PAUL ANDREASSEN
  • Sudha Sharma
  • Simon Powell
  • Rachel Litman
  • Robert M Brosh
  • Min Peng
  • Jenny Xie
  • Rigu Gupta
  • Roger A Greenberg
  • David M Livingston
  • Woo S Joo
  • Shawna Guillemette
  • Stephanie Maniatis
  • Scott A Shaffer
  • Steven Quan
  • Aditya Venkatesh
  • Yuliang Wu
  • Joshua A Sommers
  • Mark K Kenny
  • Yoshihiro Nakatani
  • Shailja Pathania
  • Bijan Sobhian
  • Fan Zhang
  • Junran Zhang
  • Zhe Jin
  • Michael S Finnin
  • Philip D Jeffrey
  • Nikola P Pavletich

Detail Information

Publications11

  1. pmc FANCJ/BACH1 acetylation at lysine 1249 regulates the DNA damage response
    Jenny Xie
    Department of Cancer Biology, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America
    PLoS Genet 8:e1002786. 2012
    ..Thus, we propose that the dynamic regulation of FANCJ acetylation is critical for robust DNA damage response, recombination-based processing, and ultimately checkpoint maintenance...
  2. pmc Hereditary breast cancer and the BRCA1-associated FANCJ/BACH1/BRIP1
    Sharon B Cantor
    Department of Cancer Biology, University of Massachusetts Medical School, 364 Plantation St, Worcester, MA 01605, USA
    Future Oncol 7:253-61. 2011
    ..In this article, we summarize the breast cancer-associated FANCJ mutations and discuss functional outcomes for DNA repair and tumor suppression...
  3. doi request reprint Assessing the link between BACH1/FANCJ and MLH1 in DNA crosslink repair
    Sharon B Cantor
    Department of Cancer Biology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Environ Mol Mutagen 51:500-7. 2010
    ..We speculate that after DNA crosslink processing and repair, the FANCJ/MLH1 interaction is critical for recovery and restart of replication. These ideas are considered and summarized in this review...
  4. ncbi request reprint Assessing the link between BACH1 and BRCA1 in the FA pathway
    Sharon B Cantor
    Department of Cancer Biology, University of Massachusetts Medical School, Women s Cancers Program, UMASS Memorial Cancer Center, Worcester, Massachusetts 01605, USA
    Cell Cycle 5:164-7. 2006
    ..We predict that BRCA1 regulates the BACH1 helicase activity to coordinate the timely displacement of Rad51 from nucleofilaments, promoting error free repair and ultimately maintaining chromosomal integrity...
  5. pmc BRCA-FA pathway as a target for anti-tumor drugs
    Rachel Litman
    Department of Cancer Biology, University of Massachusetts Medical School, 364 Plantation St, Worcester, MA 01605, USA
    Anticancer Agents Med Chem 8:426-30. 2008
    ..In the future, identifying patients with susceptible tumors and discovering additional DNA repair targets amenable to anti-tumor drugs will have a major impact on the course of cancer treatment...
  6. pmc The FANCJ/MutLalpha interaction is required for correction of the cross-link response in FA-J cells
    Min Peng
    Department of Cancer Biology, University of Massachusetts Medical School Women s Cancers Program, UMASS Memorial Cancer Center, Worcester, MA, USA
    EMBO J 26:3238-49. 2007
    ..The functional role of the FANCJ/MutLalpha complex demonstrates a novel link between FA and MMR, and predicts a broader role for FANCJ in DNA damage signaling independent of BRCA1...
  7. pmc The BRCA1-associated protein BACH1 is a DNA helicase targeted by clinically relevant inactivating mutations
    Sharon Cantor
    Department of Cancer Biology, University of Massachusetts Medical School, Lazare Research Building, Worcester, MA 01605, USA
    Proc Natl Acad Sci U S A 101:2357-62. 2004
    ..These results reinforce the notion that mutant BACH1 participates in breast cancer development...
  8. ncbi request reprint BACH1 is critical for homologous recombination and appears to be the Fanconi anemia gene product FANCJ
    Rachel Litman
    Department of Cancer Biology, University of Massachusetts Medical School, Worcester, 01605, USA
    Cancer Cell 8:255-65. 2005
    ..These results support the conclusion that BACH1 is FANCJ...
  9. pmc FANCJ (BACH1) helicase forms DNA damage inducible foci with replication protein A and interacts physically and functionally with the single-stranded DNA-binding protein
    Rigu Gupta
    Laboratory of Molecular Gerontology, National Institute on Aging NIA, National Institutes of Health NIH, Baltimore, MD 21224, USA
    Blood 110:2390-8. 2007
    ..These findings identify RPA as the first regulatory partner of FANCJ. The FANCJ-RPA interaction is likely to be important for the role of the helicase to more efficiently unwind DNA repair intermediates to maintain genomic stability...
  10. pmc Multifactorial contributions to an acute DNA damage response by BRCA1/BARD1-containing complexes
    Roger A Greenberg
    Department of Genetics, Harvard Medical School and the Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
    Genes Dev 20:34-46. 2006
    ..The results support a new, multifactorial model that describes how genotoxic stress enables BRCA1 to execute a diverse set of DNA damage-response functions...
  11. pmc Structure of the 53BP1 BRCT region bound to p53 and its comparison to the Brca1 BRCT structure
    Woo S Joo
    Cellular Biochemistry and Biophysics Program, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Genes Dev 16:583-93. 2002
    ..The BACH1-binding region of Brca1 consists of a unique insertion in the first BRCT repeat and the inter-repeat linker and is analogous to the region of 53BP1 that binds p53...

Research Grants4

  1. BACH1/FANCJ Checkpoint, Recombination, and Chemoresistance
    Sharon B Cantor; Fiscal Year: 2010
    ..Along these lines, we will test whether manipulation of the recombination function of the BACH1/BRCA1 complex will uniquely sensitizes MMR deficient cells to chemotherapies. ..
  2. BACH1/FANCJ Checkpoint, Recombination, and Chemoresistance
    Sharon Cantor; Fiscal Year: 2007
    ..Along these lines, we will test whether manipulation of the recombination function of the BACH1/BRCA1 complex will uniquely sensitizes MMR deficient cells to chemotherapies. ..