T D Cannon

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi Phospholipids and insulin resistance in psychosis: a lipidomics study of twin pairs discordant for schizophrenia
    Matej Oresic
    VTT Technical Research Centre of Finland, Tietotie 2, Espoo, FI 02044 VTT, Finland
    Genome Med 4:1. 2012
  2. ncbi Early and late neurodevelopmental influences in the prodrome to schizophrenia: contributions of genes, environment, and their interactions
    Tyrone D Cannon
    Department of Psychology, University of California, Los Angeles, 90095, USA
    Schizophr Bull 29:653-69. 2003
  3. ncbi Decreased neurotrophic response to birth hypoxia in the etiology of schizophrenia
    Tyrone D Cannon
    Department of Psychology, University of California Los Angeles, Los Angeles, California 90095 1563, USA
    Biol Psychiatry 64:797-802. 2008
  4. ncbi Levels of analysis in etiological research on schizophrenia
    Tyrone D Cannon
    Department of Psychology, University of California, Los Angeles 90095, USA
    Dev Psychopathol 14:653-66. 2002
  5. ncbi Prediction of psychosis in youth at high clinical risk: a multisite longitudinal study in North America
    Tyrone D Cannon
    Department of Psychology, University of California, Los Angeles, 1285 Franz Hall, Los Angeles, CA 90095
    Arch Gen Psychiatry 65:28-37. 2008
  6. ncbi The empirical status of the ultra high-risk (prodromal) research paradigm
    Tyrone D Cannon
    Department of Psychology, University of California, Los Angeles, CA, USA
    Schizophr Bull 33:661-4. 2007
  7. ncbi Mapping heritability and molecular genetic associations with cortical features using probabilistic brain atlases: methods and applications to schizophrenia
    Tyrone D Cannon
    Department of Psychology, UCLA, Los Angeles, CA 90095, USA
    Neuroinformatics 4:5-19. 2006
  8. ncbi Association of DISC1/TRAX haplotypes with schizophrenia, reduced prefrontal gray matter, and impaired short- and long-term memory
    Tyrone D Cannon
    Department of Psychology, 1285 Franz Hall, University of California Los Angeles, Los Angeles, CA 90095, USA
    Arch Gen Psychiatry 62:1205-13. 2005
  9. ncbi Dorsolateral prefrontal cortex activity during maintenance and manipulation of information in working memory in patients with schizophrenia
    Tyrone D Cannon
    Department of Psychology, University of California, Los Angeles 90095 1563, USA
    Arch Gen Psychiatry 62:1071-80. 2005
  10. ncbi Endophenotypes in the genetic analyses of mental disorders
    Tyrone D Cannon
    Department of Psychology, University of California, Los Angeles, California 90095, USA
    Annu Rev Clin Psychol 2:267-90. 2006

Research Grants

  1. Neural Phenotypes for Schizophrenia and Bipolar Disorder
    Tyrone Cannon; Fiscal Year: 2009
  2. Neural Phenotypes for Schizophrenia and Bipolar Disorder
    Tyrone Cannon; Fiscal Year: 2007
  3. Working Memory and Social Functioning in Schizophrenia
    Tyrone Cannon; Fiscal Year: 2007
  4. BRAIN FUNCTION AND STRUCTURE IN TWINS WITH SCHIZOPHRENIA
    Tyrone Cannon; Fiscal Year: 2003
  5. Neural Phenotypes for Schizophrenia and Bipolar Disorder
    Tyrone D Cannon; Fiscal Year: 2010

Detail Information

Publications95

  1. ncbi Phospholipids and insulin resistance in psychosis: a lipidomics study of twin pairs discordant for schizophrenia
    Matej Oresic
    VTT Technical Research Centre of Finland, Tietotie 2, Espoo, FI 02044 VTT, Finland
    Genome Med 4:1. 2012
    ..The 'prostaglandin deficiency' hypothesis postulates that defective enzyme systems converting essential fatty acids to prostaglandins lead to diminished levels of prostaglandins, which in turn affect synaptic transmission...
  2. ncbi Early and late neurodevelopmental influences in the prodrome to schizophrenia: contributions of genes, environment, and their interactions
    Tyrone D Cannon
    Department of Psychology, University of California, Los Angeles, 90095, USA
    Schizophr Bull 29:653-69. 2003
    ....
  3. ncbi Decreased neurotrophic response to birth hypoxia in the etiology of schizophrenia
    Tyrone D Cannon
    Department of Psychology, University of California Los Angeles, Los Angeles, California 90095 1563, USA
    Biol Psychiatry 64:797-802. 2008
    ....
  4. ncbi Levels of analysis in etiological research on schizophrenia
    Tyrone D Cannon
    Department of Psychology, University of California, Los Angeles 90095, USA
    Dev Psychopathol 14:653-66. 2002
    ..In recognition of the myriad complexities of multifactorial causation, we argue that a multilevel causal perspective is required for the development and advancement of a fully nuanced theory of schizophrenia etiology and pathophysiology...
  5. ncbi Prediction of psychosis in youth at high clinical risk: a multisite longitudinal study in North America
    Tyrone D Cannon
    Department of Psychology, University of California, Los Angeles, 1285 Franz Hall, Los Angeles, CA 90095
    Arch Gen Psychiatry 65:28-37. 2008
    ....
  6. ncbi The empirical status of the ultra high-risk (prodromal) research paradigm
    Tyrone D Cannon
    Department of Psychology, University of California, Los Angeles, CA, USA
    Schizophr Bull 33:661-4. 2007
    ....
  7. ncbi Mapping heritability and molecular genetic associations with cortical features using probabilistic brain atlases: methods and applications to schizophrenia
    Tyrone D Cannon
    Department of Psychology, UCLA, Los Angeles, CA 90095, USA
    Neuroinformatics 4:5-19. 2006
    ....
  8. ncbi Association of DISC1/TRAX haplotypes with schizophrenia, reduced prefrontal gray matter, and impaired short- and long-term memory
    Tyrone D Cannon
    Department of Psychology, 1285 Franz Hall, University of California Los Angeles, Los Angeles, CA 90095, USA
    Arch Gen Psychiatry 62:1205-13. 2005
    ..Chromosome 1q42 is among several genomic regions showing replicated evidence of linkage with schizophrenia, but the specific susceptibility mechanisms underlying this relationship remain to be identified...
  9. ncbi Dorsolateral prefrontal cortex activity during maintenance and manipulation of information in working memory in patients with schizophrenia
    Tyrone D Cannon
    Department of Psychology, University of California, Los Angeles 90095 1563, USA
    Arch Gen Psychiatry 62:1071-80. 2005
    ..It remains unclear whether altered regional brain physiological activity in patients with schizophrenia during working memory tasks relates to maintenance-related processes, manipulation-related (ie, executive) processes, or both...
  10. ncbi Endophenotypes in the genetic analyses of mental disorders
    Tyrone D Cannon
    Department of Psychology, University of California, Los Angeles, California 90095, USA
    Annu Rev Clin Psychol 2:267-90. 2006
    ....
  11. ncbi Clinical and genetic high-risk strategies in understanding vulnerability to psychosis
    Tyrone D Cannon
    Department of Psychology, University of California, Los Angeles, 1285 Franz Hall, Los Angeles, CA 90095, USA
    Schizophr Res 79:35-44. 2005
    ..Preliminary results from longitudinal studies of individuals ascertained initially in a prodromal (i.e., "clinical high-risk") state appear to be interpretable within this framework...
  12. ncbi Antipsychotic drug treatment in the prodromal phase of schizophrenia
    Tyrone D Cannon
    Department of Psychology, University of California Los Angeles, 1285 Franz Hall, Los Angeles, CA 90095, USA
    Am J Psychiatry 159:1230-2. 2002
    ..The safety and tolerability of short-term treatment with a low dose of risperidone was evaluated in adolescents with prodromal symptoms and a family history of schizophrenia...
  13. ncbi Quantitative neural indicators of liability to schizophrenia: implications for molecular genetic studies
    T D Cannon
    Department of Psychology, UCLA, Los Angeles, California 90095 1563, USA
    Am J Med Genet 105:16-9. 2001
    ....
  14. ncbi Cortex mapping reveals regionally specific patterns of genetic and disease-specific gray-matter deficits in twins discordant for schizophrenia
    Tyrone D Cannon
    Department of Psychology, University of California, 1285 Franz Hall, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 99:3228-33. 2002
    ....
  15. ncbi Elucidating continuities and discontinuities between schizotypy and schizophrenia in the nervous system
    Tyrone D Cannon
    Department of Psychology, Psychiatry and Biobehavioral Sciences, UCLA, 1285 Franz Hall, Box 951563, Los Angeles, CA 90095 1563, USA
    Schizophr Res 54:151-6. 2002
    ....
  16. ncbi Fetal hypoxia and structural brain abnormalities in schizophrenic patients, their siblings, and controls
    Tyrone D Cannon
    Department of Psychology, University of California, Los Angeles, 1285 Franz Hall, Los Angeles, CA 90095, USA
    Arch Gen Psychiatry 59:35-41. 2002
    ..Cortical gray matter reductions and cerebrospinal fluid (CSF) increases are robust correlates of schizophrenia, but their relationships to obstetric and other etiologic risk factors remain to be established...
  17. ncbi What is the role of theories in the study of schizophrenia?
    Tyrone D Cannon
    Schizophr Bull 35:563-7. 2009
    ....
  18. ncbi The inheritance of neuropsychological dysfunction in twins discordant for schizophrenia
    T D Cannon
    Department of Psychology, UCLA, 90095, USA
    Am J Hum Genet 67:369-82. 2000
    ..On tests of verbal and visual episodic memory, but not on the liability-related measures, patients were more impaired than their own MZ co-twins, suggesting a preferential impact of nongenetic influences on long-term memory systems...
  19. ncbi Childhood cognitive functioning in schizophrenia patients and their unaffected siblings: a prospective cohort study
    T D Cannon
    Department of Psychology, University of California, Los Angeles, 90095 1563, USA
    Schizophr Bull 26:379-93. 2000
    ....
  20. ncbi A prospective cohort study of genetic and perinatal influences in the etiology of schizophrenia
    T D Cannon
    Department of Psychology, University of California, Los Angeles 90095 1563, USA
    Schizophr Bull 26:351-66. 2000
    ..We propose a model in which the neurotoxic effects of fetal hypoxia may lead to an earlier onset of psychosis because of premature pruning of cortical synapses...
  21. ncbi The genetic epidemiology of schizophrenia in a Finnish twin cohort. A population-based modeling study
    T D Cannon
    Department of Psychology, University of Pennsylvania, Philadelphia, USA
    Arch Gen Psychiatry 55:67-74. 1998
    ..We applied structural equation modeling in a total population of twins to determine the significance and magnitudes of the genetic and environmental contributions to schizophrenia...
  22. ncbi Regional gray matter, white matter, and cerebrospinal fluid distributions in schizophrenic patients, their siblings, and controls
    T D Cannon
    Department of Psychology, University of Pennsylvania, Philadelphia 19104 6196, USA
    Arch Gen Psychiatry 55:1084-91. 1998
    ..Cortical gray matter volume reductions and cerebrospinal fluid (CSF) volume increases are robust correlates of schizophrenia, but their sources have not been established conclusively...
  23. ncbi The relationship between performance and fMRI signal during working memory in patients with schizophrenia, unaffected co-twins, and control subjects
    Katherine H Karlsgodt
    Department of Psychology, UCLA, Los Angeles, CA 90095 1563, USA
    Schizophr Res 89:191-7. 2007
    ..Further, this study offers preliminary evidence that the relationship between behavior and physiology in schizophrenia may be heritable...
  24. ncbi Genetic contributions to altered callosal morphology in schizophrenia
    Katherine L Narr
    Laboratory of Neuro Imaging, Neuropsychiatric Institute, University of California at Los Angeles School of Medicine, Los Angeles, California 90095-1769, USA
    J Neurosci 22:3720-9. 2002
    ..An upward bowing of the callosum may thus provide an easily identifiable neuroanatomic marker to screen individuals possessing a biological vulnerability for schizophrenia...
  25. ncbi Proton MRS in twin pairs discordant for schizophrenia
    E S Lutkenhoff
    Department of Neuroscience IDP, UCLA, Los Angeles, CA, USA
    Mol Psychiatry 15:308-18. 2010
    ..Thus, reduced mesial prefrontal cortical Glu and elevated hippocampal NAA, Cr and Cho may represent trait markers of schizophrenia risk and, when exacerbated, state markers of schizophrenia itself...
  26. ncbi Language network dysfunction as a predictor of outcome in youth at clinical high risk for psychosis
    Fred W Sabb
    Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, Box 956968, Rm 2265, 300 Medical Plaza, Los Angeles, CA 90095 6968, USA
    Schizophr Res 116:173-83. 2010
    ..Yet, no study to date has investigated underlying neural networks associated with discourse processing in adolescents at clinical high risk (CHR) for developing psychosis(1)...
  27. ncbi Challenges in phenotype definition in the whole-genome era: multivariate models of memory and intelligence
    F W Sabb
    Consortium for Neuropsychiatric Phenomics, Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine, UCLA, Los Angeles, CA 90095, USA
    Neuroscience 164:88-107. 2009
    ..These results are available online through the http://www.phenowiki.org database. Further work needs to be done in order to provide consensus-building applications for the broadly defined constructs used in neuroscience research...
  28. ncbi Attentional dysfunctions in neuroleptic-naive and neuroleptic-withdrawn schizophrenic patients and their siblings
    J R Finkelstein
    Department of Psychology, University of Pennsylvania, Philadelphia 19104, USA
    J Abnorm Psychol 106:203-12. 1997
    ..The results suggest that attentional deficits, as measured by this CPT, appear to measure stable markers of schizophrenia that may be associated with genetic vulnerability to the illness...
  29. ncbi Genetic influences on brain structure
    P M Thompson
    Laboratory of Neuro Imaging and Brain Mapping Division, Department of Neurology, UCLA School of Medicine, 710 Westwood Plaza, Los Angeles, California 90095 1769, USA
    Nat Neurosci 4:1253-8. 2001
    ..05). These genetic brain maps reveal how genes determine individual differences, and may shed light on the heritability of cognitive and linguistic skills, as well as genetic liability for diseases that affect the human cortex...
  30. ncbi Symptomatic and functional correlates of regional brain physiology during working memory processing in patients with recent onset schizophrenia
    Jacqueline H Sanz
    Department of Psychology, University of California Los Angeles, Los Angeles, CA 90095, United States
    Psychiatry Res 173:177-82. 2009
    ....
  31. ncbi Do schizotypal symptoms mediate the relationship between genetic risk for schizophrenia and impaired neuropsychological performance in co-twins of schizophrenic patients?
    Jennifer K Johnson
    Department of Psychology JKJ, University of California at Los Angeles, Los Angeles, California California 90095 1563, USA
    Biol Psychiatry 54:1200-4. 2003
    ....
  32. ncbi Gene-environment interaction and covariation in schizophrenia: the role of obstetric complications
    Vijay A Mittal
    Department of Psychiatry and Behavioral Sciences, University of California Los Angeles, 1285 Franz Hall, Los Angeles, CA 90095 6968, USA
    Schizophr Bull 34:1083-94. 2008
    ....
  33. ncbi Spatial working memory as an endophenotype for schizophrenia
    David C Glahn
    Department of Psychology, University of California Los Angeles, Los Angeles, California, USA
    Biol Psychiatry 53:624-6. 2003
    ..CONCLUSIONS: The findings suggest that deficits in the encoding or storage aspects of short-term spatial mnemonic processing may be an effective endophenotypic marker for schizophrenia...
  34. ncbi The relation of antipsychotic and antidepressant medication with baseline symptoms and symptom progression: a naturalistic study of the North American Prodrome Longitudinal Sample
    Elaine F Walker
    Department of Psychology, Emory University, Atlanta, GA 30322, USA
    Schizophr Res 115:50-7. 2009
    ..The results are discussed in light of the relative risks and benefits of preventive interventions, both medication and cognitive therapies, and the importance of future clinical trials...
  35. ncbi A prospective study of childhood neurocognitive functioning in schizophrenic patients and their siblings
    Tara A Niendam
    Department of Psychology, University of California-Los Angeles, Los Angeles, CA 90095, USA
    Am J Psychiatry 160:2060-2. 2003
    ..However, the probands exhibited more severe deficits in perceptual-motor speed and speeded processes of working memory than their unaffected siblings...
  36. ncbi Genetic linkage and association between chromosome 1q and working memory function in schizophrenia
    Timothy L Gasperoni
    Department of Psychology, UCLA, Los Angeles, California 90095-1563, USA
    Am J Med Genet B Neuropsychiatr Genet 116:8-16. 2003
    ..These data support the utility of this approach and provide evidence for a gene affecting spatial working memory function in schizophrenia patients and their unaffected co-twins...
  37. ncbi Re-evaluating dorsolateral prefrontal cortex activation during working memory in schizophrenia
    Katherine H Karlsgodt
    Department of Psychology, UCLA, 1285 Franz Hall, Box 951563, Los Angeles, CA 90095 1563, USA
    Schizophr Res 108:143-50. 2009
    ....
  38. ncbi Mapping cortical thickness in children with 22q11.2 deletions
    Carrie E Bearden
    Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, CA 90095, USA
    Cereb Cortex 17:1889-98. 2007
    ..These brain maps reveal how haploinsufficiency for such genes can affect cortical development and suggest a possible underlying pathophysiology of the neurobehavioral phenotype...
  39. ncbi Hippocampal volumes in schizophrenic twins
    Theo G M van Erp
    Department of Psychology, University of California, Los Angeles, 90095, USA
    Arch Gen Psychiatry 61:346-53. 2004
    ..The results are discussed in view of assumptions underlying classic twin methods...
  40. ncbi Elucidating a magnetic resonance imaging-based neuroanatomic biomarker for psychosis: classification analysis using probabilistic brain atlas and machine learning algorithms
    Daqiang Sun
    Department of Psychology, University of California at Los Angeles, 90095, USA
    Biol Psychiatry 66:1055-60. 2009
    ..Recently, efforts have been made to discriminate psychotic patients from healthy individuals using machine-learning-based pattern classification methods on MRI data...
  41. ncbi Phenomics: the systematic study of phenotypes on a genome-wide scale
    R M Bilder
    Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at University of California, Los Angeles, CA, USA
    Neuroscience 164:30-42. 2009
    ....
  42. ncbi Common and dissociable prefrontal loci associated with component mechanisms of analogical reasoning
    Soohyun Cho
    Department of Psychology, University of California, Los Angeles, Los Angeles, CA 90095 1563, USA
    Cereb Cortex 20:524-33. 2010
    ....
  43. ncbi Abnormally high EEG alpha synchrony during working memory maintenance in twins discordant for schizophrenia
    Peter Bachman
    Department of Psychology, University of California, Los Angeles, 1285 Franz Hall, Box 951563, Los Angeles, CA 90095 1563, United States
    Schizophr Res 103:293-7. 2008
    ....
  44. ncbi Alterations in midline cortical thickness and gyrification patterns mapped in children with 22q11.2 deletions
    Carrie E Bearden
    Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, University of California Los Angeles, Los Angeles, CA 90024, USA
    Cereb Cortex 19:115-26. 2009
    ....
  45. ncbi Verbal recall and recognition in twins discordant for schizophrenia
    Theo G M van Erp
    Department of Psychology, UCLA, 1285 Franz Hall, Box 951563, Los Angeles, CA 90095, USA
    Psychiatry Res 159:271-80. 2008
    ....
  46. ncbi Efficiency of working memory encoding in twins discordant for schizophrenia
    Peter Bachman
    Department of Psychology, University of California, Los Angeles, Los Angeles, CA 90095 1563, United States
    Psychiatry Res 174:97-104. 2009
    ..Furthermore, this inefficiency appeared during the late stimulus encoding stage of working memory functioning, possibly reflecting disruptions in stimulus representation consolidation...
  47. ncbi Neural phenotypes of common and rare genetic variants
    Carrie E Bearden
    Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, CA, United States
    Biol Psychol 79:43-57. 2008
    ..Finally, we discuss the contribution of behavioral neurogenetics research to our understanding of the genetic basis of neuropsychiatric disorders in the broader population...
  48. ncbi A twin study of genetic contributions to hippocampal morphology in schizophrenia
    Katherine L Narr
    Laboratory of Neuro-Imaging, Brain Mapping Center, Department of Neurology, UCLA Brain Mapping Center, UCLA School of Medicine, Los Angeles, California 90095, USA
    Neurobiol Dis 11:83-95. 2002
    ..Results suggest that hippocampal volume reduction may be a trait marker for identifying individuals possessing a genetic predisposition for schizophrenia...
  49. ncbi Analogical reasoning in working memory: resources shared among relational integration, interference resolution, and maintenance
    Soohyun Cho
    Department of Psychology, University of California, Los Angeles, California 90095 1563, USA
    Mem Cognit 35:1445-55. 2007
    ..The findings provide evidence that relational integration and interference resolution depend on shared cognitive resources in working memory during analogical reasoning...
  50. ncbi Gender differences in symptoms, functioning and social support in patients at ultra-high risk for developing a psychotic disorder
    Rachael K Willhite
    University of California, Los Angeles, Department of Psychology, Los Angeles, CA 90095, United States
    Schizophr Res 104:237-45. 2008
    ..Follow-up studies should examine the relationship between symptoms, functioning and social support in this population...
  51. ncbi Identification and treatment of a pineal region tumor in an adolescent with prodromal psychotic symptoms
    Vijay A Mittal
    Department of Psychology, University of California Los Angeles, USA
    Am J Psychiatry 167:1033-7. 2010
    ..Etiological pathways that may have played a role in symptom development are of particular interest, as understanding these mechanisms may shed light on the pathophysiology of psychotic disorders more generally...
  52. ncbi Developmental disruptions in neural connectivity in the pathophysiology of schizophrenia
    Katherine H Karlsgodt
    Department of Psychology, 1285 Franz Hall Box 951563, University of California, Los Angeles, Los Angeles, CA 90095 1563, USA
    Dev Psychopathol 20:1297-327. 2008
    ....
  53. ncbi Markers of basal ganglia dysfunction and conversion to psychosis: neurocognitive deficits and dyskinesias in the prodromal period
    Vijay A Mittal
    Department of Psychology, University of California Los Angeles, Los Angeles, California, USA
    Biol Psychiatry 68:93-9. 2010
    ....
  54. ncbi Family problem solving interactions and 6-month symptomatic and functional outcomes in youth at ultra-high risk for psychosis and with recent onset psychotic symptoms: a longitudinal study
    Mary P O'Brien
    Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, CA 90095, United States
    Schizophr Res 107:198-205. 2009
    ....
  55. ncbi Obsessive compulsive symptoms in the psychosis prodrome: correlates of clinical and functional outcome
    Tara A Niendam
    Department of Psychology, University of California, Los Angeles, 1285 Franz Hall, Box 951563, Los Angeles, CA 90095 1563, USA
    Schizophr Res 108:170-5. 2009
    ..However, the prevalence of obsessive compulsive symptomatology (OCS) and its relationship to outcome has not been evaluated in adolescents at ultra high-risk for psychosis (UHR)...
  56. ncbi Predicting the longitudinal effects of the family environment on prodromal symptoms and functioning in patients at-risk for psychosis
    Danielle A Schlosser
    University of California at Los Angeles, 300 Medical Plaza, Box 666824, Los Angeles, CA 90095, United States
    Schizophr Res 118:69-75. 2010
    ..These results suggest that the family environment should be a specific target of treatment for individuals at risk for psychosis...
  57. ncbi Integrity of emotional and motivational states during the prodromal, first-episode, and chronic phases of schizophrenia
    Cindy M Yee
    Department of Psychology, University of California, Los Angeles, Los Angeles, CA 90095 1563, USA
    J Abnorm Psychol 119:71-82. 2010
    ....
  58. ncbi White matter integrity and prediction of social and role functioning in subjects at ultra-high risk for psychosis
    Katherine H Karlsgodt
    Department of Psychology, University of California, Los Angeles UCLA, California 90095 1563, USA
    Biol Psychiatry 66:562-9. 2009
    ....
  59. ncbi Dysbindin modulates prefrontal cortical glutamatergic circuits and working memory function in mice
    James David Jentsch
    Department of Psychology, University of California, Los Angeles, CA 90095 1563, USA
    Neuropsychopharmacology 34:2601-8. 2009
    ....
  60. ncbi The prodromal questionnaire (PQ): preliminary validation of a self-report screening measure for prodromal and psychotic syndromes
    Rachel L Loewy
    Department of Psychology, University of California, Los Angeles, 1285 Franz Hall, Box 951563, Los Angeles, CA 90095 1563, USA
    Schizophr Res 77:141-9. 2005
    ..The PQ shows good preliminary validity in detecting individuals with an interview-diagnosed prodromal or psychotic syndrome, but it is less sensitive to the threshold between prodromal and full-blown psychosis...
  61. ncbi Diffusion tensor imaging of the superior longitudinal fasciculus and working memory in recent-onset schizophrenia
    Katherine H Karlsgodt
    Department of Psychology, University of California, Los Angeles, California 90095 1563, USA
    Biol Psychiatry 63:512-8. 2008
    ....
  62. ncbi Mapping genetic influences on human brain structure
    Paul Thompson
    Laboratory of Neuro Imaging and Brain Mapping Division, Department of Neurology, UCLA School of Medicine, 710 Westwood Plaza, Los Angeles, CA 90095 1769, USA
    Ann Med 34:523-36. 2002
    ..Computational methods from brain imaging and genetics can be fruitfully merged, to shed light on the inheritance of personality differences and behavioral traits, and the genetic transmission of diseases that affect the human brain...
  63. ncbi Maintenance and manipulation of information in schizophrenia: further evidence for impairment in the central executive component of working memory
    Junghoon Kim
    Department of Psychology, University of California, Los Angeles, 1285 Franz Hall, Box 951563, Los Angeles, CA 90095 1563, USA
    Schizophr Res 68:173-87. 2004
    ..These results suggest that while both maintenance and central executive aspects of working memory are impaired in schizophrenic patients, the central executive may be more severely affected...
  64. ncbi Positive family environment predicts improvement in symptoms and social functioning among adolescents at imminent risk for onset of psychosis
    Mary P O'Brien
    Department of Psychiatry, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, USA
    Schizophr Res 81:269-75. 2006
    ....
  65. ncbi The prodromal questionnaire (PQ): preliminary validation of a self-report screening measure for prodromal and psychotic syndromes
    Rachel L Loewy
    Department of Psychology, University of California, Los Angeles, 1285 Franz Hall Box 951563, Los Angeles, CA 90095 1563, USA
    Schizophr Res 79:117-25. 2005
    ..The PQ shows good preliminary validity in detecting individuals with an interview-diagnosed prodromal or psychotic syndrome, but it is less sensitive to the threshold between prodromal and full-blown psychosis...
  66. ncbi The psychosis prodrome in adolescent patients viewed through the lens of DSM-IV
    Stephanie E Meyer
    Division of Child and Adolescent Psychiatry, Neuropsychiatric Institute and Hospital, University of California Los Angeles, CA 90024, USA
    J Child Adolesc Psychopharmacol 15:434-51. 2005
    ..However, the array of symptomatology in these patients is broad and has not yet been systematically characterized using established diagnostic and assessment tools...
  67. ncbi Hippocampal activations during encoding and retrieval in a verbal working memory paradigm
    Katherine H Karlsgodt
    Department of Psychology, UCLA, 1285 Franz Hall, Los Angeles, CA 90095 1563, USA
    Neuroimage 25:1224-31. 2005
    ....
  68. ncbi Regional brain abnormalities in 22q11.2 deletion syndrome: association with cognitive abilities and behavioral symptoms
    Carrie E Bearden
    Department of Psychiatry and Biobehavioral Sciences, UCLA, Los Angeles, CA 90095, USA
    Neurocase 10:198-206. 2004
    ..Although preliminary,these findings suggest a possible underlying pathophysiology of the cognitive deficits seen in this syndrome,and provide insight into complex gene-brain-behavior relationships...
  69. ncbi Mapping cortical change in Alzheimer's disease, brain development, and schizophrenia
    Paul M Thompson
    Laboratory of Neuro Imaging, Brain Mapping Division, Department of Neurology, UCLA School of Medicine, Los Angeles, CA 90095 1769, USA
    Neuroimage 23:S2-18. 2004
    ..Dynamically spreading waves of gray matter loss are tracked in dementia and schizophrenia, and these sequences are related to normally occurring changes in healthy subjects of various ages...
  70. ncbi The course of neurocognition and social functioning in individuals at ultra high risk for psychosis
    Tara A Niendam
    Department of Psychology, University of California, Los Angeles, 1285 Franz Hall, Box 951563, Los Angeles, CA 90095 1563, USA
    Schizophr Bull 33:772-81. 2007
    ..This study evaluates longitudinal neuropsychological performance and its association with clinical symptomatology and psychosocial outcome in individuals identified as ultra high risk (UHR) for psychosis...
  71. ncbi Cortical mapping of genotype-phenotype relationships in schizophrenia
    Carrie E Bearden
    Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, California 90095, USA
    Hum Brain Mapp 28:519-32. 2007
    ....
  72. ncbi Remember and know judgments during recognition in chronic schizophrenia
    Theo G M van Erp
    Department of Psychology, UCLA, Los Angeles, CA 90095, USA
    Schizophr Res 100:181-90. 2008
    ..Taken together, these findings are consistent with a deficit in recollection and increased reliance on familiarity in making recognition memory judgments in chronic schizophrenia...
  73. ncbi The effects of genetic liability for schizophrenia and maternal smoking during pregnancy on obstetric complications
    Lauren M Ellman
    UCLA Psychology Department, 1285 Franz Hall, Box 951563, Los Angeles, CA 90095 1563, United States
    Schizophr Res 93:229-36. 2007
    ..The purpose of this study was to determine whether a genetic vulnerability for schizophrenia and/or health-risk behaviors among schizophrenic pregnant women were associated with an increased incidence of obstetric complications (OCs)...
  74. ncbi Ecological assessment of executive dysfunction in the psychosis prodrome: a pilot study
    Tara A Niendam
    Department of Psychology, University of California, Los Angeles, 1285 Franz Hall, Box 951563, Los Angeles, CA 90095 1563, United States
    Schizophr Res 93:350-4. 2007
    ..The BRIEF appears to capture unique aspects of executive dysfunction, possibly associated with illness progression and functioning in the psychosis prodrome...
  75. ncbi Parent attitudes and parent adolescent interaction in families of youth at risk for psychosis and with recent-onset psychotic symptoms
    Mary P O'Brien
    Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, Brain Research Institute, University of California, Los Angeles, CA, USA
    Early Interv Psychiatry 2:268-76. 2008
    ..This study investigated the behavioural correlates of caregiver attitudes among parents of youth at risk for psychosis and with recent-onset psychotic symptoms...
  76. ncbi Psychoeducational multi-family group treatment with adolescents at high risk for developing psychosis
    Mary P O'Brien
    Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, California 90095, USA
    Early Interv Psychiatry 1:325-32. 2007
    ..In this study, we investigate the feasibility and acceptability of a 9-month psychoeducational multi-family group (PMFG) intervention for adolescents who are at ultra-high-risk (UHR) for developing psychosis...
  77. ncbi Manifest disease and motor cortex reactivity in twins discordant for schizophrenia
    Martin Schürmann
    Brain Research Unit, Helsinki University of Technology, Finland
    Br J Psychiatry 191:178-9. 2007
    ..During action observation and execution, motor cortex reaction was weaker in those with schizophrenia than in their co-twins, suggesting a disease-related dysfunction of motor cognition...
  78. ncbi Spatial working memory function in twins with schizophrenia and bipolar disorder
    Tiia Pirkola
    Department of Mental Health and Alcohol Research, National Public Health Institute, Helsinki, Finland
    Biol Psychiatry 58:930-6. 2005
    ..Here, we evaluated whether such deficits might also mark genetic susceptibility to bipolar disorder...
  79. ncbi Preliminary findings for two new measures of social and role functioning in the prodromal phase of schizophrenia
    Barbara A Cornblatt
    Recognition and Prevention Program, Department of Psychiatry Research, The Zucker Hillside Hospital, North Shore Long Island Jewish Health System, 75 59 263rd Street, Glen Oaks, NY 11004, USA
    Schizophr Bull 33:688-702. 2007
    ....
  80. ncbi Memory and verbal learning functions in twins with bipolar-I disorder, and the role of information-processing speed
    Tuula Kieseppä
    Department of Mental Health and Alcohol Research, National Public Health Institute, Helsinki, Finland
    Psychol Med 35:205-15. 2005
    ..The authors compared verbal learning and memory functioning in twins with BP I and co-twins to control twins, and examined whether the observed deficits are related to information-processing speed...
  81. ncbi Increased caudate dopamine D2 receptor availability as a genetic marker for schizophrenia
    Jussi Hirvonen
    Department of Pharmacology and Clinical Pharmacology, and Turku PET Centre, University of Turku, Kiinamyllynkatu, Turku 20520, Finland
    Arch Gen Psychiatry 62:371-8. 2005
    ..This pattern of results provides a theoretical rationale for early pharmacologic intervention approaches using dopamine D(2) receptor blocking drugs...
  82. ncbi Search for cognitive trait components of schizophrenia reveals a locus for verbal learning and memory on 4q and for visual working memory on 2q
    Tiina Paunio
    Department of Molecular Medicine, National Public Health Institute, Helsinki, Finland
    Hum Mol Genet 13:1693-702. 2004
    ..Our results reveal initial information on the effect of the loci associated with schizophrenia in multiple studies, and emphasize the value of trait components in the search for susceptibility loci for complex diseases...
  83. ncbi Reduced left hemispheric white matter volume in twins with bipolar I disorder
    Tuula Kieseppä
    Department of Mental Health and Alcohol Research, University of Helsinki, Finland
    Biol Psychiatry 54:896-905. 2003
    ....
  84. ncbi Neurocognitive performance and functional disability in the psychosis prodrome
    Tara A Niendam
    Department of Psychology, University of California, Los Angeles, Los Angeles, CA 90095 1563, USA
    Schizophr Res 84:100-11. 2006
    ..This study evaluates the pattern of neuropsychological deficits and their association with clinical symptomatology and social functioning in individuals identified as ultra-high-risk (UHR) for psychosis...
  85. ncbi Regional brain morphology and duration of illness in never-medicated first-episode patients with schizophrenia
    Jarmo Hietala
    Schizophr Res 64:79-81. 2003
  86. ncbi Striatal dopamine D1 and D2 receptor balance in twins at increased genetic risk for schizophrenia
    Jussi Hirvonen
    Department of Psychiatry, University of Turku, 20520, Finland
    Psychiatry Res 146:13-20. 2006
    ..In this sample, we did not find evidence for an association between increased genetic risk for schizophrenia and altered D1/D2 receptor balance in the striatum...
  87. ncbi Self-report of attenuated psychotic experiences in a college population
    Rachel L Loewy
    Department of Psychology, University of California, Los Angeles, 1285 Franz Hall, Box 951563, Los Angeles, CA 90095 1563, USA
    Schizophr Res 93:144-51. 2007
    ....
  88. ncbi Inherited auditory-cortical dysfunction in twin pairs discordant for schizophrenia
    Jyrki Ahveninen
    Department of Radiology, Harvard Medical School Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
    Biol Psychiatry 60:612-20. 2006
    ..We used magnetoencephalography (MEG) and electroencephalography (EEG) to investigate the inheritance of auditory-cortical deficiencies in twin pairs discordant for schizophrenia...
  89. ncbi Brain dopamine d1 receptors in twins discordant for schizophrenia
    Jussi Hirvonen
    Department of Psychiatry, University of Turku, Kunnallissairaalantie 20, Bldg. 9, 20700 Turku, Finland
    Am J Psychiatry 163:1747-53. 2006
    ..In addition, the data indicate a widespread reduction of D(1) receptor binding in medicated schizophrenia patients, supporting a link between antipsychotic drug action and dopamine D(1) receptor down-regulation...
  90. ncbi Heritability and number of quantitative trait loci of neurocognitive functions in families with schizophrenia
    Annamari Tuulio-Henriksson
    Department of Mental Health and Alcohol Research, National Public Health Institute of Finland, Helsinki
    Am J Med Genet 114:483-90. 2002
    ..Our results suggest that neurocognitive measures, particularly working memory, may provide valid quantitative phenotypic traits for linkage analyses searching predisposing genes for schizophrenia...
  91. ncbi North American Prodrome Longitudinal Study: a collaborative multisite approach to prodromal schizophrenia research
    Jean Addington
    Centre for Addiction and Mental Health, 250 College Street, Toronto, Ontario, M5T 1R8, Canada
    Schizophr Bull 33:665-72. 2007
    ....
  92. ncbi Contributions of genetic risk and fetal hypoxia to hippocampal volume in patients with schizophrenia or schizoaffective disorder, their unaffected siblings, and healthy unrelated volunteers
    Theo G M van Erp
    UCLA Department of Psychology, 90095, USA
    Am J Psychiatry 159:1514-20. 2002
    ..They further suggest that hippocampal volume in schizophrenia or schizoaffective disorder may be linked to time of disease onset...
  93. ncbi Maternal exposure to herpes simplex virus and risk of psychosis among adult offspring
    Stephen L Buka
    Brown University Department of Community Health, Providence, Rhode Island 02806, USA
    Biol Psychiatry 63:809-15. 2008
    ..In this investigation, we tested a large and diverse population to assess the risk of psychoses among offspring of mothers with serological evidence of HSV-2 infection...
  94. ncbi Specific developmental disruption of disrupted-in-schizophrenia-1 function results in schizophrenia-related phenotypes in mice
    Weidong Li
    Department of Neurobiology, Semel Institute, Brain Research Institute, and Department of Urology, University of California, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 104:18280-5. 2007
    ..Our findings demonstrate that alterations in DISC1 function during brain development contribute to schizophrenia pathogenesis...
  95. ncbi The HMG-CoA reductase inhibitor lovastatin reverses the learning and attention deficits in a mouse model of neurofibromatosis type 1
    Weidong Li
    Department of Neurobiology, University of California, Los Angeles, Los Angeles, California 90095, USA
    Curr Biol 15:1961-7. 2005
    ..Therefore, these results demonstrate that lovastatin may prove useful in the treatment of Neurofibromatosis Type 1...

Research Grants18

  1. Neural Phenotypes for Schizophrenia and Bipolar Disorder
    Tyrone Cannon; Fiscal Year: 2009
    ....
  2. Neural Phenotypes for Schizophrenia and Bipolar Disorder
    Tyrone Cannon; Fiscal Year: 2007
    ....
  3. Working Memory and Social Functioning in Schizophrenia
    Tyrone Cannon; Fiscal Year: 2007
    ..abstract_text> ..
  4. BRAIN FUNCTION AND STRUCTURE IN TWINS WITH SCHIZOPHRENIA
    Tyrone Cannon; Fiscal Year: 2003
    ..abstract_text> ..
  5. Neural Phenotypes for Schizophrenia and Bipolar Disorder
    Tyrone D Cannon; Fiscal Year: 2010
    ....