Research Topics
Species | Martin CannonSummaryAffiliation: University of Arkansas for Medical Sciences Country: USA Publications
Research Grants
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Detail Information
Publications
Dendritic cell vaccination against ovarian cancer--tipping the Treg/TH17 balance to therapeutic advantage?Martin J Cannon
Expert Opin Biol Ther 11:441-5. 2011..We also discuss pharmacological approaches to modulation of MAP kinase signaling for manipulation of the functional plasticity of DC, such that they may be directed to promote T(H)17 responses following DC vaccination...- Cellular immunotherapy for ovarian cancerMartin J Cannon
University of Arkansas for Medical Sciences, Department of Microbiology and Immunology, 4301 West Markham, Little Rock, AR 72205, USA
Expert Opin Biol Ther 9:677-88. 2009..Cellular immunotherapy may offer the prospect of treatment to prevent or delay recurrent metastatic disease... 
Definition of an immunogenic region within the ovarian tumor antigen stratum corneum chymotryptic enzymeKristina L Bondurant
Department of Microbiology, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA
Clin Cancer Res 11:3446-54. 2005..CONCLUSIONS: The 110-139 region of SCCE incorporates multiple CD8+ CTL and CD4+ helper T cell epitopes, and represents an attractive target antigen for immunotherapy of ovarian cancer...- CD4+ T cell-induced differentiation of EBV-transformed lymphoblastoid cells is associated with diminished recognition by EBV-specific CD8+ cytotoxic T cellsAaruni Khanolkar
Department of Microbiology and Immunology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
J Immunol 170:3187-94. 2003..Finally, transwell cocultures, in which direct LCL-CD4(+) T cell contact was prevented, indicated a major role for CD4(+) T cell cytokines in the differentiation of LCL... - Dendritic cells and macrophages are productively infected by poliovirusRahnuma Wahid
Department of Microbiology and Immunology, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA
J Virol 79:401-9. 2005.... - Restoration of tumor-specific HLA class I restricted cytotoxicity in tumor infiltrating lymphocytes of advanced breast cancer patients by in vitro stimulation with tumor antigen-pulsed autologous dendritic cellsRena Kass
Department of General Surgery, University of Arkansas for Medical Sciences, Little Rock, AR 72205-7199, USA
Breast Cancer Res Treat 80:275-85. 2003..These results may have important implications for the treatment of chemotherapy resistant breast cancer with active or adoptive immunotherapy... - Effect of blood transfusion during radiotherapy on the immune function of patients with cancer of the uterine cervix: role of interleukin-10Alessandro D Santin
Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, University of Arkansas for Medical Sciences, Little Rock, AR 72205 7199, USA
Int J Radiat Oncol Biol Phys 54:1345-55. 2002..To analyze prospectively the effects of blood transfusion administered during radiotherapy (RT) on the immune function of patients with locally advanced cervical cancer... - Induction of tumor-specific cytotoxicity in tumor infiltrating lymphocytes by HPV16 and HPV18 E7-pulsed autologous dendritic cells in patients with cancer of the uterine cervixAlessandro D Santin
Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, University of Arkansas for Medical Sciences, Little Rock 72205 7199, USA
Gynecol Oncol 89:271-80. 2003.... - An HLA-E single chain trimer inhibits human NK cell reactivity towards porcine cellsMark D Crew
Central Arkansas Veterans Healthcare System, University of Arkansas for Medical Sciences 151 Research, 4300 West 7th Street, Little Rock, AR 72205, USA
Mol Immunol 42:1205-14. 2005..Thus, HLA-E SCT, in which all three components of a normal HLA-E protein complex are in one polypeptide chain, is immunologically functional as it is able to modulate NK cell cytotoxicity and cytokine secretion... - Virus-specific CD4+ and CD8+ cytotoxic T-cell responses and long-term T-cell memory in individuals vaccinated against polioRahnuma Wahid
Department of Microbiology and Immunology, University of Arkansas for Medical Sciences, 4301 W Markham St, Slot 511, Little Rock, AR 72205, USA
J Virol 79:5988-95. 2005..Thus, immunity to PV vaccination involves not only an effective neutralizing antibody titer but also long-term CD4(+) and CD8(+) cytotoxic T-cell responses... - Treatment of chemotherapy-resistant human ovarian cancer xenografts in C.B-17/SCID mice by intraperitoneal administration of Clostridium perfringens enterotoxinAlessandro D Santin
Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205 7199, USA
Cancer Res 65:4334-42. 2005..e., 4-week established OVA-1). Our findings suggest that CPE may have potential as a novel treatment for chemotherapy-resistant/recurrent ovarian cancer... - Therapeutic vaccines for cervical cancer: dendritic cell-based immunotherapyAlessandro D Santin
Department of Obstetrics and Gynecology, University of Arkansas for Medical Sciences, 4301 West Markham, Little Rock, AR 72205, USA
Curr Pharm Des 11:3485-500. 2005.... - HPV16/18 E7-pulsed dendritic cell vaccination in cervical cancer patients with recurrent disease refractory to standard treatment modalitiesAlessandro D Santin
Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, University of Arkansas for Medical Sciences, 4301 W Markham, Little Rock, AR 72205 7199, USA
Gynecol Oncol 100:469-78. 2006.... - Recognition of a cervical cancer derived tumor cell line by a human papillomavirus type 16 E6 52-61-specific CD8 T cell cloneKevin H Kim
Department of Dermatology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
Cancer Immun 6:9. 2006.... - Advances in dendritic-cell-based therapeutic vaccines for cervical cancerStefania Bellone
University of Arkansas for Medical Sciences, Department of Obstetrics and Gynecology, 4301 West Markham, Little Rock, AR 72205, USA
Expert Rev Anticancer Ther 7:1473-86. 2007.... - Human papillomavirus type 16 and 18 E7-pulsed dendritic cell vaccination of stage IB or IIA cervical cancer patients: a phase I escalating-dose trialAlessandro D Santin
UAMS Medical Center, Division of Gynecologic Oncology, University of Arkansas, 4301 W Markham, Little Rock, AR 72205 7199, USA
J Virol 82:1968-79. 2008..Phase II E7-pulsed DC-based vaccination trials with cervical cancer patients harboring a limited tumor burden, or who are at significant risk of tumor recurrence, are warranted... - Racial differences in the overexpression of epidermal growth factor type II receptor (HER2/neu): a major prognostic indicator in uterine serous papillary cancerAlessandro D Santin
Division of Gynecologic Oncology, University of Arkansas for Medical Sciences, Little Rock, AR 72205 7199, USA
Am J Obstet Gynecol 192:813-8. 2005.... - Gene expression profiles of primary HPV16- and HPV18-infected early stage cervical cancers and normal cervical epithelium: identification of novel candidate molecular markers for cervical cancer diagnosis and therapyAlessandro D Santin
Division of Gynecologic Oncology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
Virology 331:269-91. 2005.... - Novel target antigens for dendritic cell-based immunotherapy against ovarian cancerMartin J Cannon
Department of Obstetrics and Gynecology, University of Arkansas for Medical Sciences, 4301 West Markham, Little Rock, AR 72205, USA
Expert Rev Anticancer Ther 2:97-105. 2002..In this review, a series of recently identified novel ovarian tumor antigens is discussed, and the potential for therapeutic dendritic cell vaccination targeted against these antigens is assessed... - Gene expression profiles in primary ovarian serous papillary tumors and normal ovarian epithelium: identification of candidate molecular markers for ovarian cancer diagnosis and therapyAlessandro D Santin
Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Arkansas for Medical Sciences, Little Rock, AR 72205 7199, USA
Int J Cancer 112:14-25. 2004..NOVA. These results, obtained with highly purified primary cultures of ovarian cancer, highlight important molecular features of OSPC and may provide a foundation for the development of new type-specific therapies against this disease... - Current treatment options for endometrial cancerAlessandro D Santin
University of Arkansas for Medical Sciences, Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, 4301 West Markham Street, Slot 518, Little Rock, AR 72205, USA
Expert Rev Anticancer Ther 4:679-89. 2004..Anti-HER-2/neu-targeted therapy might be a novel and attractive therapeutic strategy in patients harboring this biologically aggressive variant of endometrial cancer... - Immunological treatment of ovarian cancerMartin J Cannon
Department of Microbiology and Immunology, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA
Curr Opin Obstet Gynecol 16:87-92. 2004..Several recent studies presented in this review, however, point to a revival of optimism for the development of novel immunotherapeutic strategies... - In vitro induction of tumor-specific HLA class I-restricted CD8+ cytotoxic T lymphocytes from patients with locally advanced breast cancer by tumor antigen-pulsed autologous dendritic cellsRena Kass
Department of Surgery, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
J Surg Res 112:189-97. 2003..Tumor antigen-pulsed DC-based vaccinations may be appropriate for the treatment of residual and/or chemotherapy-resistant breast cancer refractory to standard salvage treatment modalities... - High serum levels of interleukin-6 in endometrial carcinoma are associated with uterine serous papillary histology, a highly aggressive and chemotherapy-resistant variant of endometrial cancerStefania Bellone
Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, University of Arkansas for Medical Sciences, Little Rock, AR, USA
Gynecol Oncol 98:92-8. 2005..IL-6 may be a novel biomarker for USPC. Drugs used to inhibit the expression of IL-6 or the IL-6 signal transduction pathway may potentially be highly beneficial in USPC... - Selection of HER-2/neu-positive tumor cells in early stage cervical cancer: implications for Herceptin-mediated therapyStefania Bellone
Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, University of Arkansas for Medical Sciences, Little Rock, AR 72205-7199, USA
Gynecol Oncol 91:231-40. 2003..Therapy which targets HER-2/neu may be more effective in patients with cervical cancer than indicated by the commonly low expression of HER-2/neu in tumors removed at the time of primary treatment... - Endemic Burkitt's lymphoma: a polymicrobial disease?Rosemary Rochford
Department of Microbiology and Immunology, SUNY Upstate Medical University, Syracuse, New York, USA
Nat Rev Microbiol 3:182-7. 2005..New data suggest how these two pathogens might interact to result in disease and provide insights into the emerging concepts of polymicrobial disease pathogenesis... - The novel serine protease tumor-associated differentially expressed gene-14 (KLK8/Neuropsin/Ovasin) is highly overexpressed in cervical cancerStefania Cane
Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
Am J Obstet Gynecol 190:60-6. 2004..The goal of this study was to investigate the frequency of expression of the TADG-14 gene in human cervical tumors... - Increased levels of gangliosides in the plasma and ascitic fluid of patients with advanced ovarian cancerAlessandro D Santin
Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA
BJOG 111:613-8. 2004..Secretion of gangliosides may play an important role in the inhibition of anti-tumour immune function commonly observed in advanced ovarian cancer... - Vaccination with HPV-18 E7-pulsed dendritic cells in a patient with metastatic cervical cancerAlessandro D Santin
N Engl J Med 346:1752-3. 2002 - Overexpression of HER-2/neu in uterine serous papillary cancerAlessandro D Santin
Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, University of Arkansas, Little Rock 72205-7199, USA
Clin Cancer Res 8:1271-9. 2002.... - Biotin dependency due to a defect in biotin transportRebecca Mardach
Regional Metabolic Service, Kaiser Permanente, Los Angeles, California, USA
J Clin Invest 109:1617-23. 2002..These results provide evidence for a novel genetic defect in biotin transport. This child is the first known with this defect, which should now be included in the identified causes of biotin dependency...
Research Grants
- Dendritic cell immunotherapy for ovarian cancerMartin Cannon; Fiscal Year: 2005..This project is designed to support the development of clinical trial protocols for therapeutic DC vaccination in patients with ovarian cancer. ..
- Novel target antigens for ovarian cancer immunotherapyMartin Cannon; Fiscal Year: 2007..This proposal is targeted at the development of clinical trial protocols for therapeutic DC vaccination for prevention of progression of ovarian cancer. ..