Martin Cannon

Summary

Affiliation: University of Arkansas for Medical Sciences
Country: USA

Publications

  1. pmc Dendritic cell vaccination against ovarian cancer--tipping the Treg/TH17 balance to therapeutic advantage?
    Martin J Cannon
    Expert Opin Biol Ther 11:441-5. 2011
  2. pmc Cellular immunotherapy for ovarian cancer
    Martin J Cannon
    University of Arkansas for Medical Sciences, Department of Microbiology and Immunology, 4301 West Markham, Little Rock, AR 72205, USA
    Expert Opin Biol Ther 9:677-88. 2009
  3. ncbi request reprint Definition of an immunogenic region within the ovarian tumor antigen stratum corneum chymotryptic enzyme
    Kristina L Bondurant
    Department of Microbiology, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA
    Clin Cancer Res 11:3446-54. 2005
  4. ncbi request reprint CD4+ T cell-induced differentiation of EBV-transformed lymphoblastoid cells is associated with diminished recognition by EBV-specific CD8+ cytotoxic T cells
    Aaruni Khanolkar
    Department of Microbiology and Immunology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
    J Immunol 170:3187-94. 2003
  5. pmc Dendritic cells and macrophages are productively infected by poliovirus
    Rahnuma Wahid
    Department of Microbiology and Immunology, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA
    J Virol 79:401-9. 2005
  6. ncbi request reprint Restoration of tumor-specific HLA class I restricted cytotoxicity in tumor infiltrating lymphocytes of advanced breast cancer patients by in vitro stimulation with tumor antigen-pulsed autologous dendritic cells
    Rena Kass
    Department of General Surgery, University of Arkansas for Medical Sciences, Little Rock, AR 72205 7199, USA
    Breast Cancer Res Treat 80:275-85. 2003
  7. ncbi request reprint Effect of blood transfusion during radiotherapy on the immune function of patients with cancer of the uterine cervix: role of interleukin-10
    Alessandro D Santin
    Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, University of Arkansas for Medical Sciences, Little Rock, AR 72205 7199, USA
    Int J Radiat Oncol Biol Phys 54:1345-55. 2002
  8. pmc Human papillomavirus type 16 and 18 E7-pulsed dendritic cell vaccination of stage IB or IIA cervical cancer patients: a phase I escalating-dose trial
    Alessandro D Santin
    UAMS Medical Center, Division of Gynecologic Oncology, University of Arkansas, 4301 W Markham, Little Rock, AR 72205 7199, USA
    J Virol 82:1968-79. 2008
  9. ncbi request reprint An HLA-E single chain trimer inhibits human NK cell reactivity towards porcine cells
    Mark D Crew
    Central Arkansas Veterans Healthcare System, University of Arkansas for Medical Sciences 151 Research, 4300 West 7th Street, Little Rock, AR 72205, USA
    Mol Immunol 42:1205-14. 2005
  10. pmc Virus-specific CD4+ and CD8+ cytotoxic T-cell responses and long-term T-cell memory in individuals vaccinated against polio
    Rahnuma Wahid
    Department of Microbiology and Immunology, University of Arkansas for Medical Sciences, 4301 W Markham St, Slot 511, Little Rock, AR 72205, USA
    J Virol 79:5988-95. 2005

Research Grants

Collaborators

Detail Information

Publications32

  1. pmc Dendritic cell vaccination against ovarian cancer--tipping the Treg/TH17 balance to therapeutic advantage?
    Martin J Cannon
    Expert Opin Biol Ther 11:441-5. 2011
    ..We also discuss pharmacological approaches to modulation of MAP kinase signaling for manipulation of the functional plasticity of DC, such that they may be directed to promote T(H)17 responses following DC vaccination...
  2. pmc Cellular immunotherapy for ovarian cancer
    Martin J Cannon
    University of Arkansas for Medical Sciences, Department of Microbiology and Immunology, 4301 West Markham, Little Rock, AR 72205, USA
    Expert Opin Biol Ther 9:677-88. 2009
    ..Cellular immunotherapy may offer the prospect of treatment to prevent or delay recurrent metastatic disease...
  3. ncbi request reprint Definition of an immunogenic region within the ovarian tumor antigen stratum corneum chymotryptic enzyme
    Kristina L Bondurant
    Department of Microbiology, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA
    Clin Cancer Res 11:3446-54. 2005
    ..In this study, we tested the hypothesis that dendritic cells loaded with SCCE peptides will induce ovarian tumor antigen-specific CD8+ CTL responses and antigen-specific CD4+ helper T cell responses...
  4. ncbi request reprint CD4+ T cell-induced differentiation of EBV-transformed lymphoblastoid cells is associated with diminished recognition by EBV-specific CD8+ cytotoxic T cells
    Aaruni Khanolkar
    Department of Microbiology and Immunology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
    J Immunol 170:3187-94. 2003
    ..Finally, transwell cocultures, in which direct LCL-CD4(+) T cell contact was prevented, indicated a major role for CD4(+) T cell cytokines in the differentiation of LCL...
  5. pmc Dendritic cells and macrophages are productively infected by poliovirus
    Rahnuma Wahid
    Department of Microbiology and Immunology, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA
    J Virol 79:401-9. 2005
    ....
  6. ncbi request reprint Restoration of tumor-specific HLA class I restricted cytotoxicity in tumor infiltrating lymphocytes of advanced breast cancer patients by in vitro stimulation with tumor antigen-pulsed autologous dendritic cells
    Rena Kass
    Department of General Surgery, University of Arkansas for Medical Sciences, Little Rock, AR 72205 7199, USA
    Breast Cancer Res Treat 80:275-85. 2003
    ..These results may have important implications for the treatment of chemotherapy resistant breast cancer with active or adoptive immunotherapy...
  7. ncbi request reprint Effect of blood transfusion during radiotherapy on the immune function of patients with cancer of the uterine cervix: role of interleukin-10
    Alessandro D Santin
    Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, University of Arkansas for Medical Sciences, Little Rock, AR 72205 7199, USA
    Int J Radiat Oncol Biol Phys 54:1345-55. 2002
    ..To analyze prospectively the effects of blood transfusion administered during radiotherapy (RT) on the immune function of patients with locally advanced cervical cancer...
  8. pmc Human papillomavirus type 16 and 18 E7-pulsed dendritic cell vaccination of stage IB or IIA cervical cancer patients: a phase I escalating-dose trial
    Alessandro D Santin
    UAMS Medical Center, Division of Gynecologic Oncology, University of Arkansas, 4301 W Markham, Little Rock, AR 72205 7199, USA
    J Virol 82:1968-79. 2008
    ..Phase II E7-pulsed DC-based vaccination trials with cervical cancer patients harboring a limited tumor burden, or who are at significant risk of tumor recurrence, are warranted...
  9. ncbi request reprint An HLA-E single chain trimer inhibits human NK cell reactivity towards porcine cells
    Mark D Crew
    Central Arkansas Veterans Healthcare System, University of Arkansas for Medical Sciences 151 Research, 4300 West 7th Street, Little Rock, AR 72205, USA
    Mol Immunol 42:1205-14. 2005
    ..Thus, HLA-E SCT, in which all three components of a normal HLA-E protein complex are in one polypeptide chain, is immunologically functional as it is able to modulate NK cell cytotoxicity and cytokine secretion...
  10. pmc Virus-specific CD4+ and CD8+ cytotoxic T-cell responses and long-term T-cell memory in individuals vaccinated against polio
    Rahnuma Wahid
    Department of Microbiology and Immunology, University of Arkansas for Medical Sciences, 4301 W Markham St, Slot 511, Little Rock, AR 72205, USA
    J Virol 79:5988-95. 2005
    ..Thus, immunity to PV vaccination involves not only an effective neutralizing antibody titer but also long-term CD4(+) and CD8(+) cytotoxic T-cell responses...
  11. ncbi request reprint Recognition of a cervical cancer derived tumor cell line by a human papillomavirus type 16 E6 52-61-specific CD8 T cell clone
    Kevin H Kim
    Department of Dermatology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
    Cancer Immun 6:9. 2006
    ....
  12. ncbi request reprint Treatment of chemotherapy-resistant human ovarian cancer xenografts in C.B-17/SCID mice by intraperitoneal administration of Clostridium perfringens enterotoxin
    Alessandro D Santin
    Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205 7199, USA
    Cancer Res 65:4334-42. 2005
    ..e., 4-week established OVA-1). Our findings suggest that CPE may have potential as a novel treatment for chemotherapy-resistant/recurrent ovarian cancer...
  13. ncbi request reprint Therapeutic vaccines for cervical cancer: dendritic cell-based immunotherapy
    Alessandro D Santin
    Department of Obstetrics and Gynecology, University of Arkansas for Medical Sciences, 4301 West Markham, Little Rock, AR 72205, USA
    Curr Pharm Des 11:3485-500. 2005
    ....
  14. ncbi request reprint HPV16/18 E7-pulsed dendritic cell vaccination in cervical cancer patients with recurrent disease refractory to standard treatment modalities
    Alessandro D Santin
    Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, University of Arkansas for Medical Sciences, 4301 W Markham, Little Rock, AR 72205 7199, USA
    Gynecol Oncol 100:469-78. 2006
    ....
  15. ncbi request reprint Advances in dendritic-cell-based therapeutic vaccines for cervical cancer
    Stefania Bellone
    University of Arkansas for Medical Sciences, Department of Obstetrics and Gynecology, 4301 West Markham, Little Rock, AR 72205, USA
    Expert Rev Anticancer Ther 7:1473-86. 2007
    ....
  16. ncbi request reprint Racial differences in the overexpression of epidermal growth factor type II receptor (HER2/neu): a major prognostic indicator in uterine serous papillary cancer
    Alessandro D Santin
    Division of Gynecologic Oncology, University of Arkansas for Medical Sciences, Little Rock, AR 72205 7199, USA
    Am J Obstet Gynecol 192:813-8. 2005
    ....
  17. ncbi request reprint Immunological treatment of ovarian cancer
    Martin J Cannon
    Department of Microbiology and Immunology, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA
    Curr Opin Obstet Gynecol 16:87-92. 2004
    ..Several recent studies presented in this review, however, point to a revival of optimism for the development of novel immunotherapeutic strategies...
  18. ncbi request reprint Gene expression profiles of primary HPV16- and HPV18-infected early stage cervical cancers and normal cervical epithelium: identification of novel candidate molecular markers for cervical cancer diagnosis and therapy
    Alessandro D Santin
    Division of Gynecologic Oncology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
    Virology 331:269-91. 2005
    ....
  19. ncbi request reprint Gene expression profiles in primary ovarian serous papillary tumors and normal ovarian epithelium: identification of candidate molecular markers for ovarian cancer diagnosis and therapy
    Alessandro D Santin
    Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Arkansas for Medical Sciences, Little Rock, AR 72205 7199, USA
    Int J Cancer 112:14-25. 2004
    ..NOVA. These results, obtained with highly purified primary cultures of ovarian cancer, highlight important molecular features of OSPC and may provide a foundation for the development of new type-specific therapies against this disease...
  20. ncbi request reprint Current treatment options for endometrial cancer
    Alessandro D Santin
    University of Arkansas for Medical Sciences, Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, 4301 West Markham Street, Slot 518, Little Rock, AR 72205, USA
    Expert Rev Anticancer Ther 4:679-89. 2004
    ..Anti-HER-2/neu-targeted therapy might be a novel and attractive therapeutic strategy in patients harboring this biologically aggressive variant of endometrial cancer...
  21. ncbi request reprint Novel target antigens for dendritic cell-based immunotherapy against ovarian cancer
    Martin J Cannon
    Department of Obstetrics and Gynecology, University of Arkansas for Medical Sciences, 4301 West Markham, Little Rock, AR 72205, USA
    Expert Rev Anticancer Ther 2:97-105. 2002
    ..In this review, a series of recently identified novel ovarian tumor antigens is discussed, and the potential for therapeutic dendritic cell vaccination targeted against these antigens is assessed...
  22. ncbi request reprint Induction of tumor-specific cytotoxicity in tumor infiltrating lymphocytes by HPV16 and HPV18 E7-pulsed autologous dendritic cells in patients with cancer of the uterine cervix
    Alessandro D Santin
    Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, University of Arkansas for Medical Sciences, Little Rock 72205 7199, USA
    Gynecol Oncol 89:271-80. 2003
    ....
  23. ncbi request reprint Selection of HER-2/neu-positive tumor cells in early stage cervical cancer: implications for Herceptin-mediated therapy
    Stefania Bellone
    Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, University of Arkansas for Medical Sciences, Little Rock, AR 72205 7199, USA
    Gynecol Oncol 91:231-40. 2003
    ....
  24. ncbi request reprint High serum levels of interleukin-6 in endometrial carcinoma are associated with uterine serous papillary histology, a highly aggressive and chemotherapy-resistant variant of endometrial cancer
    Stefania Bellone
    Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, University of Arkansas for Medical Sciences, Little Rock, AR, USA
    Gynecol Oncol 98:92-8. 2005
    ....
  25. ncbi request reprint In vitro induction of tumor-specific HLA class I-restricted CD8+ cytotoxic T lymphocytes from patients with locally advanced breast cancer by tumor antigen-pulsed autologous dendritic cells
    Rena Kass
    Department of Surgery, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
    J Surg Res 112:189-97. 2003
    ..Dendritic cells (DCs) are the most powerful antigen-presenting cells, and recently DC-based vaccination has shown great promise for the treatment of human malignancies by immunological intervention...
  26. ncbi request reprint Endemic Burkitt's lymphoma: a polymicrobial disease?
    Rosemary Rochford
    Department of Microbiology and Immunology, SUNY Upstate Medical University, Syracuse, New York, USA
    Nat Rev Microbiol 3:182-7. 2005
    ..New data suggest how these two pathogens might interact to result in disease and provide insights into the emerging concepts of polymicrobial disease pathogenesis...
  27. ncbi request reprint The novel serine protease tumor-associated differentially expressed gene-14 (KLK8/Neuropsin/Ovasin) is highly overexpressed in cervical cancer
    Stefania Cane
    Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
    Am J Obstet Gynecol 190:60-6. 2004
    ..The goal of this study was to investigate the frequency of expression of the TADG-14 gene in human cervical tumors...
  28. ncbi request reprint Increased levels of gangliosides in the plasma and ascitic fluid of patients with advanced ovarian cancer
    Alessandro D Santin
    Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA
    BJOG 111:613-8. 2004
    ..To assess the expression of total gangliosides in primary ovarian cancer cell lines, ascitic fluid and plasma of advanced ovarian cancer patients...
  29. ncbi request reprint Vaccination with HPV-18 E7-pulsed dendritic cells in a patient with metastatic cervical cancer
    Alessandro D Santin
    N Engl J Med 346:1752-3. 2002
  30. ncbi request reprint Overexpression of HER-2/neu in uterine serous papillary cancer
    Alessandro D Santin
    Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, University of Arkansas, Little Rock 72205 7199, USA
    Clin Cancer Res 8:1271-9. 2002
    ..In this study, we have evaluated the expression of HER-2/neu in several fresh, established, paraffin-embedded, fixed USPCs. In addition, we have tested the sensitivity of USPC cells to Herceptin treatment...
  31. pmc Biotin dependency due to a defect in biotin transport
    Rebecca Mardach
    Regional Metabolic Service, Kaiser Permanente, Los Angeles, California, USA
    J Clin Invest 109:1617-23. 2002
    ..These results provide evidence for a novel genetic defect in biotin transport. This child is the first known with this defect, which should now be included in the identified causes of biotin dependency...

Research Grants5

  1. Dendritic cell immunotherapy for ovarian cancer
    Martin Cannon; Fiscal Year: 2005
    ..This project is designed to support the development of clinical trial protocols for therapeutic DC vaccination in patients with ovarian cancer. ..
  2. Novel target antigens for ovarian cancer immunotherapy
    Martin Cannon; Fiscal Year: 2007
    ..This proposal is targeted at the development of clinical trial protocols for therapeutic DC vaccination for prevention of progression of ovarian cancer. ..