MICHAEL PAUL CANCRO

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. pmc Roles for BLyS family members in meeting the distinct homeostatic demands of innate and adaptive B cells
    Vishal J Sindhava
    Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania Philadelphia, PA, USA
    Front Immunol 4:37. 2013
  2. ncbi request reprint B cells and aging: gauging the interplay of generative, selective, and homeostatic events
    Michael P Cancro
    University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Immunol Rev 205:48-59. 2005
  3. pmc The BLyS/BAFF family of ligands and receptors: key targets in the therapy and understanding of autoimmunity
    M P Cancro
    Department of Pathology, 284 John Morgan Building, University of Pennsylvania School of Medicine, 36th and Hamilton Walk, Philadelphia, PA 19104 6082, USA
    Ann Rheum Dis 65:iii34-6. 2006
  4. ncbi request reprint B cell maturation and selection at the marrow-periphery interface
    M P Cancro
    Dept of Pathol, Univ of Penn, Philadelphia 19104, USA
    Immunol Res 17:3-11. 1998
  5. doi request reprint Living in context with the survival factor BAFF
    Michael P Cancro
    Department of Pathology and Laboratory Medicine, 284 John Morgan Building, University of Pennsylvania School of Medicine, 36th and Hamilton Walk, Philadelphia, PA 19104 6082, USA
    Immunity 28:300-1. 2008
  6. pmc The role of B lymphocyte stimulator (BLyS) in systemic lupus erythematosus
    Michael P Cancro
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, 19104 6082, USA
    J Clin Invest 119:1066-73. 2009
  7. pmc B cells and aging: molecules and mechanisms
    Michael P Cancro
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6082, USA
    Trends Immunol 30:313-8. 2009
  8. pmc Signalling crosstalk in B cells: managing worth and need
    Michael P Cancro
    284 John Morgan Building, University of Pennsylvania School of Medicine, 36th and Hamilton Walk, Philadelphia, Pennsylvania 19104, USA
    Nat Rev Immunol 9:657-61. 2009
  9. pmc An eruption of European B-cell biology
    Michael P Cancro
    University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    EMBO Rep 11:653-4. 2010
  10. ncbi request reprint Crossing the threshold of lymphocyte activation
    Michael P Cancro
    University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6082, USA
    J Immunol 174:5159-60. 2005

Collaborators

Detail Information

Publications40

  1. pmc Roles for BLyS family members in meeting the distinct homeostatic demands of innate and adaptive B cells
    Vishal J Sindhava
    Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania Philadelphia, PA, USA
    Front Immunol 4:37. 2013
    ..Finally, we extend our working model of B cell homeostasis to integrate B-1s...
  2. ncbi request reprint B cells and aging: gauging the interplay of generative, selective, and homeostatic events
    Michael P Cancro
    University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Immunol Rev 205:48-59. 2005
    ....
  3. pmc The BLyS/BAFF family of ligands and receptors: key targets in the therapy and understanding of autoimmunity
    M P Cancro
    Department of Pathology, 284 John Morgan Building, University of Pennsylvania School of Medicine, 36th and Hamilton Walk, Philadelphia, PA 19104 6082, USA
    Ann Rheum Dis 65:iii34-6. 2006
    ....
  4. ncbi request reprint B cell maturation and selection at the marrow-periphery interface
    M P Cancro
    Dept of Pathol, Univ of Penn, Philadelphia 19104, USA
    Immunol Res 17:3-11. 1998
    ....
  5. doi request reprint Living in context with the survival factor BAFF
    Michael P Cancro
    Department of Pathology and Laboratory Medicine, 284 John Morgan Building, University of Pennsylvania School of Medicine, 36th and Hamilton Walk, Philadelphia, PA 19104 6082, USA
    Immunity 28:300-1. 2008
    ..2008) show that BAFF, a tumor necrosis factor (TNF) family member, promotes B cell survival by hindering interactions between TNF-receptor-associated factors, blocking their negative regulation of nonclassical NF-kappaB activity...
  6. pmc The role of B lymphocyte stimulator (BLyS) in systemic lupus erythematosus
    Michael P Cancro
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, 19104 6082, USA
    J Clin Invest 119:1066-73. 2009
    ..This review discusses the mechanism of BLyS action on B cells, its role in SLE, and specific targeting of BLyS in the treatment of SLE...
  7. pmc B cells and aging: molecules and mechanisms
    Michael P Cancro
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6082, USA
    Trends Immunol 30:313-8. 2009
    ..Together, these findings set the stage for integrated analyses of how age-related changes at the molecular, cellular and population levels interact to yield the overall aging phenotype...
  8. pmc Signalling crosstalk in B cells: managing worth and need
    Michael P Cancro
    284 John Morgan Building, University of Pennsylvania School of Medicine, 36th and Hamilton Walk, Philadelphia, Pennsylvania 19104, USA
    Nat Rev Immunol 9:657-61. 2009
    ....
  9. pmc An eruption of European B-cell biology
    Michael P Cancro
    University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    EMBO Rep 11:653-4. 2010
    ..Volcanic ash clouds disrupted the 2010 ESF/EMBO meeting on B cells and protection. Nevertheless, the delegates who did make it to Catalonia put together their own programme of talks covering a range of themes from mutualism to epigenetics...
  10. ncbi request reprint Crossing the threshold of lymphocyte activation
    Michael P Cancro
    University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6082, USA
    J Immunol 174:5159-60. 2005
  11. ncbi request reprint The BLyS family of ligands and receptors: an archetype for niche-specific homeostatic regulation
    Michael P Cancro
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6082, USA
    Immunol Rev 202:237-49. 2004
    ..Differential expression of the three BLyS receptors during differentiation and activation provides related yet distinct homeostatic niches for follicular, marginal zone, and memory B-cell subsets...
  12. ncbi request reprint Peripheral B cell selection and homeostasis
    Michael P Cancro
    University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6082, USA
    Immunol Res 27:141-8. 2003
    ..Our results indicate that the size and dynamics of most B cell subsets shift with age, suggesting age-associated alterations in both intrinsic and microenvironmental factors that govern these processes...
  13. ncbi request reprint B cell positive selection: road map to the primary repertoire?
    Michael P Cancro
    Department of Pathology, University of Pennsylvania School of Medicine, John Morgan Building Room 284, 36th and Hamilton Walk, Philadelphia, PA 19104, USA
    J Immunol 173:15-9. 2004
    ..Together, these observations suggest that positive selection is a critical feature in the establishment and maintenance of all lymphocyte pools, prompting re-evaluation of the underlying biological rationale for this process...
  14. ncbi request reprint Peripheral B-cell maturation: the intersection of selection and homeostasis
    Michael P Cancro
    Department of Pathology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6082, USA
    Immunol Rev 197:89-101. 2004
    ....
  15. ncbi request reprint Integrating B cell homeostasis and selection with BLyS
    Susan Harless Smith
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Arch Immunol Ther Exp (Warsz) 51:209-18. 2003
    ....
  16. ncbi request reprint Space, selection, and surveillance: setting boundaries with BLyS
    Juli P Miller
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Immunol 176:6405-10. 2006
    ..BLyS responsiveness thus balances peripheral selection against cell numbers, providing an elastic system that varies selective stringency based on homeostatic demands...
  17. ncbi request reprint Cutting edge: BLyS enables survival of transitional and mature B cells through distinct mediators
    Benjamin L Hsu
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Immunol 168:5993-6. 2002
    ....
  18. ncbi request reprint Cutting edge: impaired transitional B cell production and selection in the nonobese diabetic mouse
    William J Quinn
    University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Immunol 176:7159-64. 2006
    ..These findings suggest that compromised TR B cell generation in NOD mice yields relaxed TR selection, affording autoreactive specificities access to mature pools...
  19. ncbi request reprint Cutting edge: B cell receptor signals regulate BLyS receptor levels in mature B cells and their immediate progenitors
    Susan Harless Smith
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Immunol 170:5820-3. 2003
    ..Together, these findings establish the coupling of BcR signaling with Bcmd/BR3 expression as a fundamental aspect of follicular B cell selection, survival, and activation...
  20. ncbi request reprint BLyS: the pivotal determinant of peripheral B cell selection and lifespan
    Susan Harless Smith
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Curr Pharm Des 9:1833-47. 2003
    ..Our rapidly expanding understanding of BLyS and its receptors may eventually afford novel pharmacologic strategies aimed at the direct manipulation of peripheral B cell selection and homeostasis...
  21. pmc The BLyS family: toward a molecular understanding of B cell homeostasis
    John F Treml
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6082, USA
    Cell Biochem Biophys 53:1-16. 2009
    ..As our understanding of this system advances, molecular targets for manipulating humoral immunity in both health and disease should be revealed...
  22. ncbi request reprint The role of BLyS/BLyS receptors in anti-chromatin B cell regulation
    Brian D Hondowicz
    The Wistar Institute, Room 276, 3601 Spruce Street, Philadelphia, PA 19104, USA
    Int Immunol 19:465-75. 2007
    ..These data suggest a novel role for TACI in anti-chromatin B cell homeostasis and differentiation...
  23. pmc B cells and aging: balancing the homeostatic equation
    Juli P Miller
    University of Pennsylvania School of Medicine, 284 John Morgan Building, Department of Pathology and Laboratory Medicine, 36th and Hamilton Walk, Philadelphia, PA 19104 6082, USA
    Exp Gerontol 42:396-9. 2007
    ....
  24. ncbi request reprint Homeostatic niche specification among naïve and activated B cells: a growing role for the BLyS family of receptors and ligands
    Jenni E Crowley
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, 284 John Morgan Building, 36th and Hamilton Walk, Philadelphia, PA 19104 8062, USA
    Semin Immunol 17:193-9. 2005
    ..These observations suggest a model whereby the regulation of BLyS receptors by differentiative and stimulatory cues yield characteristic BLyS receptor signatures, thus specifying homeostatic niche and competitive advantage...
  25. ncbi request reprint Tipping the scales of selection with BAFF
    Michael P Cancro
    284 John Morgan, Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Immunity 20:655-6. 2004
    ..Two recent Immunity papers link peripheral tolerance with the ability of developing B cells to capture BAFF. These findings suggest that an increase in effective BAFF levels leads to autoreactive B cell maturation...
  26. ncbi request reprint Dwindling competition with constant demand: can homeostatic adjustments explain age-associated changes in peripheral B cell selection?
    William J Quinn
    University of Pennsylvania School of Medicine, Department of Pathology and Laboratory Medicine, 284 John Morgan Building, 36th and Hamilton Walk, Philadelphia, PA 19104 8062, USA
    Semin Immunol 17:362-9. 2005
    ..We propose a model whereby these "distal" homeostatic adjustments relax the stringency of specificity based selection, affording a potential explanation for the increased frequency of autoreactive specificities with age...
  27. ncbi request reprint BLyS receptor signatures resolve homeostatically independent compartments among naïve and antigen-experienced B cells
    Laura S Treml
    Department of Pathology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6082, USA
    Semin Immunol 18:297-304. 2006
    ..Further, within each niche, relative fitness to compete for available cytokine is determined by exogenous inputs via adaptive and innate receptor systems, affording intramural hierarchies that determine clonotype composition...
  28. ncbi request reprint An increased frequency of autoantibody-inducing CD4+ T cells in pre-diseased lupus-prone mice
    Brian W Busser
    Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Int Immunol 16:1001-7. 2004
    ..Interestingly, these autoantibody-inducing CD4+ T-cell responses are also present in the thymus. Therefore, an elevated frequency of autoantibody-inducing CD4+ T cells predisposes lupus-prone mice to the development of autoantibodies...
  29. ncbi request reprint Unraveling the warp and weft of B cell fate
    Jason E Stadanlick
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Immunity 25:395-6. 2006
    ..Two recent Immunity articles (Enzler et al., 2006; Sasaki et al., 2006) probe the roles of Nuclear Factor kappa-B (NF-kappaB) pathways in survival and differentiation mediated by B cell activation factor of the TNF family (BAFF)...
  30. pmc Tonic B cell antigen receptor signals supply an NF-kappaB substrate for prosurvival BLyS signaling
    Jason E Stadanlick
    Deparment of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Nat Immunol 9:1379-87. 2008
    ..Our findings identify a molecular mechanism for the reliance of primary B cells on continuous BR3 and BCR signaling, as well as for the gradual resistance to negative selection that is acquired during B cell maturation...
  31. pmc A role for IL-27p28 as an antagonist of gp130-mediated signaling
    Jason S Stumhofer
    University of Pennsylvania School of Veterinary Medicine, Philadelphia, PA, USA
    Nat Immunol 11:1119-26. 2010
    ..Thus, IL-27p28, as a natural antagonist of gp130-mediated signaling, may be useful as a therapeutic for managing inflammation mediated by cytokines that signal through gp130...
  32. pmc Manipulating B cell homeostasis: a key component in the advancement of targeted strategies
    Laura S Treml
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6082, USA
    Arch Immunol Ther Exp (Warsz) 56:153-64. 2008
    ..BLyS family ligands and receptors also play a role in activated and memory B cell pools, suggesting they might likewise be targeted to promote or delete particular antigen-experienced subpopulations in a similar way...
  33. pmc In vivo BLyS/BAFF neutralization ameliorates islet-directed autoimmunity in nonobese diabetic mice
    Ghazal Zekavat
    Department of Surgery, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Immunol 181:8133-44. 2008
    ..Overall, this study demonstrates the efficacy of B lymphocyte-directed therapy via in vivo BLyS neutralization for the prevention of autoimmune diabetes...
  34. pmc BLyS inhibition eliminates primary B cells but leaves natural and acquired humoral immunity intact
    Jean L Scholz
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6082, USA
    Proc Natl Acad Sci U S A 105:15517-22. 2008
    ..Together, these findings show that memory B cells and natural antibody-secreting cells are BLyS-independent and suggest that these pools can be separately manipulated...
  35. pmc FcgammaRIIB signals inhibit BLyS signaling and BCR-mediated BLyS receptor up-regulation
    Jenni E Crowley
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Blood 113:1464-73. 2009
    ..These findings link the negative regulatory functions of FcgammaRIIB with BLyS-mediated B-cell survival...
  36. pmc Homeostatic control of B lymphocyte subsets
    Jenni E Crowley
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, 284 John Morgan Building 36th and Hamilton Walk, Philadelphia, PA, 19104 6082, USA
    Immunol Res 42:75-83. 2008
    ..A refined understanding of these relationships should yield insight into the selection and maintenance of B cell subsets, as well as an appreciation of how homeostatic mechanisms may contribute to immunosenescence...
  37. ncbi request reprint TLR stimulation modifies BLyS receptor expression in follicular and marginal zone B cells
    Laura S Treml
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, 36th and Hamilton Walk, Philadelphia, PA 19104, USA
    J Immunol 178:7531-9. 2007
    ..However, although BLyS enhances viability among TLR stimulated B cells, APRIL does not, suggesting that TACI but not BLyS receptor 3 may share survival promoting pathways with TLRs...
  38. pmc Mechanism and regulatory function of CpG signaling via scavenger receptor B1 in primary B cells
    Peimin Zhu
    Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6010, USA
    J Biol Chem 284:22878-87. 2009
    ..Consequently, these results have wide implications for understanding the mechanisms regulating immune tolerance to nucleic acids and pathogen-associated molecules...
  39. pmc Exploring human/animal intersections: converging lines of evidence in comparative models of aging
    John Q Trojanowski
    School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
    Alzheimers Dement 4:1-5. 2008
    ..Instead, an optimal translational research model supports a bidirectional flow of information from animal models to clinical research...
  40. pmc BAFF and the plasticity of peripheral B cell tolerance
    Jason E Stadanlick
    Department of Pathology and Laboratory Medicine, University of Pennsylvania, 36th and Hamilton Walk, Philadelphia, PA 19104 6082, United States
    Curr Opin Immunol 20:158-61. 2008
    ..Moreover, it implies a developmentally regulated coupling of BCR and BAFF receptors at the transitional stages and beyond...

Research Grants27

  1. Lymphocyte homeostastis & regulation during aging
    Michael Cancro; Fiscal Year: 2007
    ..abstract_text> ..
  2. ROLE OF BLYS IN PERIPHERAL B CELL SELECTION AND SURVIVAL
    Michael Cancro; Fiscal Year: 2007
    ..The resulting antisera will be assessed for broadly neutralizing activity in vitro using a well-established virus pseudotype assay. ..
  3. Transitional B cell selection during peripheral B lymphopenia and reconstitution
    Michael Cancro; Fiscal Year: 2009
    ..We will assess whether reduced available BLyS levels will restore normal selective stringency by in vivo treatment with soluble TACI Ig or neutralizing anti-BLyS antibody in normal and autoimmune models. ..
  4. Lymphocyte homeostastis & regulation during aging
    Michael Cancro; Fiscal Year: 2009
    ..abstract_text> ..
  5. Transitional B cell selection during peripheral B lymphopenia and reconstitution
    MICHAEL PAUL CANCRO; Fiscal Year: 2010
    ..We will assess whether reduced available BLyS levels will restore normal selective stringency by in vivo treatment with soluble TACI Ig or neutralizing anti-BLyS antibody in normal and autoimmune models. ..
  6. Lymphocyte homeostastis & regulation during aging
    MICHAEL PAUL CANCRO; Fiscal Year: 2010
    ..abstract_text> ..
  7. Transitional B cell selection during peripheral B lymphopenia and reconstitution
    Michael Cancro; Fiscal Year: 2009
    ..We will assess whether reduced available BLyS levels will restore normal selective stringency by in vivo treatment with soluble TACI Ig or neutralizing anti-BLyS antibody in normal and autoimmune models. ..
  8. Lymphocyte homeostastis & regulation during aging
    Michael Cancro; Fiscal Year: 2006
    ..abstract_text> ..
  9. Transitional B cell selection during peripheral B lymphopenia and reconstitution
    Michael Cancro; Fiscal Year: 2007
    ..We will assess whether reduced available BLyS levels will restore normal selective stringency by in vivo treatment with soluble TACI Ig or neutralizing anti-BLyS antibody in normal and autoimmune models. ..
  10. Immune System Development and Regulation
    Michael Cancro; Fiscal Year: 2007
    ..In this regard, the ISDR will foster research and research training that bears directly on control and manipulation of the immune system in health and disease. ..
  11. B CELL DEFICIENCY IN A/WYSNJ MICE
    Michael Cancro; Fiscal Year: 1999
    ....
  12. B LYMPHOCYTE GENERATION AND SELECTION IN AGED MICE
    Michael Cancro; Fiscal Year: 2000
    ..In the fourth aim, the life span, homing characteristics, and repertoire diversity of recirculating mature B-cells in aged marrow will be determined, to assess the identity and functional significance of this population. ..
  13. B CELL DEFICIENCY IN A/WYSNJ MICE
    Michael Cancro; Fiscal Year: 2000
    ....
  14. B CELL DEFICIENCY IN A/WYSNJ MICE
    Michael Cancro; Fiscal Year: 2001
    ....
  15. B LYMPHOCYTE GENERATION AND SELECTION IN AGED MICE
    Michael Cancro; Fiscal Year: 2001
    ..In the fourth aim, the life span, homing characteristics, and repertoire diversity of recirculating mature B-cells in aged marrow will be determined, to assess the identity and functional significance of this population. ..
  16. B LYMPHOCYTE GENERATION AND SELECTION IN AGED MICE
    Michael Cancro; Fiscal Year: 2002
    ..In the fourth aim, the life span, homing characteristics, and repertoire diversity of recirculating mature B-cells in aged marrow will be determined, to assess the identity and functional significance of this population. ..
  17. B LYMPHOCYTE GENERATION AND SELECTION IN AGED MICE
    Michael Cancro; Fiscal Year: 2003
    ..In the fourth aim, the life span, homing characteristics, and repertoire diversity of recirculating mature B-cells in aged marrow will be determined, to assess the identity and functional significance of this population. ..
  18. ROLE OF BLYS IN PERIPHERAL B CELL SELECTION AND SURVIVAL
    Michael Cancro; Fiscal Year: 2004
    ..A/WySnJ mice. ..
  19. ROLE OF BLYS IN PERIPHERAL B CELL SELECTION AND SURVIVAL
    Michael Cancro; Fiscal Year: 2005
    ..A/WySnJ mice. ..
  20. ROLE OF BLYS IN PERIPHERAL B CELL SELECTION AND SURVIVAL
    Michael Cancro; Fiscal Year: 2006
    ..A/WySnJ mice. ..
  21. ROLE OF BLYS IN PERIPHERAL B CELL SELECTION AND SURVIVAL
    Michael Cancro; Fiscal Year: 2007
    ..A/WySnJ mice. ..
  22. Transitional B cell selection during peripheral B lymphopenia and reconstitution
    MICHAEL PAUL CANCRO; Fiscal Year: 2010
    ..We will assess whether reduced available BLyS levels will restore normal selective stringency by in vivo treatment with soluble TACI Ig or neutralizing anti-BLyS antibody in normal and autoimmune models. ..