Research Topics
| Arezoo CampbellSummaryAffiliation: University of California Country: USA Publications
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Detail Information
Publications
Aluminum-induced oxidative events in cell lines: glioma are more responsive than neuroblastomaA Campbell
Center for Occupational and Environmental Health, Department of Community and Environmental Medicine, University of California Irvine, 92697 1825, USA
Free Radic Biol Med 26:1166-71. 1999..Thus, it is possible that the cerebral target following an acute exposure to aluminum may be glial rather than neuronal...- Inflammation, neurodegenerative diseases, and environmental exposuresArezoo Campbell
Department of Community and Environmental Medicine, University of California, 92697 1825, USA
Ann N Y Acad Sci 1035:117-32. 2004..These factors may enhance existing age-related inflammation in the central nervous system and thus accelerate neuronal toxicity... - Particulate matter in polluted air may increase biomarkers of inflammation in mouse brainA Campbell
Department of Community and Environmental Medicine, University of California, Irvine, CA 92697 1825, USA
Neurotoxicology 26:133-40. 2005..These data indicate that components of inhaled particulate matter may trigger a proinflammatory response in nervous tissue that could contribute to the pathophysiology of neurodegenerative diseases... - Chronic exposure to aluminum in drinking water increases inflammatory parameters selectively in the brainA Campbell
Department of Community and Environmental Medicine, Center for Occupational and Environmental Health Sciences, Irvine, California 92697, USA
J Neurosci Res 75:565-72. 2004.... - Pro-inflammatory effects of aluminum in human glioblastoma cellsArezoo Campbell
Department of Community and Environmental Medicine, Center for Occupational and Environmental Health, University of California Irvine, Irvine, CA 92697 1820, USA
Brain Res 933:60-5. 2002..This may reflect the ability of the cells to discern different stress factors and thus orchestrate an innate immune response profile distinct to each immunogen... - The potential role of aluminium in Alzheimer's diseaseArezoo Campbell
Department of Community and Environmental Medicine, College of Medicine, Faculty Research Facility, University of California, Irvine, CA 92697 1825, USA
Nephrol Dial Transplant 17:17-20. 2002..The results discussed here have broad implications for the role played by aluminium and other metals in neurodegenerative diseases, and suggest that long-term exposure to supra-physiological amounts these metals should be avoided... - beta-amyloid: friend or foeA Campbell
Department of Community and Environmental Medicine, University of California, CA, USA
Med Hypotheses 56:388-91. 2001..Here, a hypothesis is presented that the protein may indeed be protective and that a potential role for beta amyloid in innate immunity may exist... - Mechanisms by which metals promote events connected to neurodegenerative diseasesA Campbell
Department of Community and Environmental Medicine, University of California, Irvine, Irvine, CA 92697 1825, USA
Brain Res Bull 55:125-32. 2001..This review addresses mechanisms by which endogenous or environmental factors, through interaction with redox active metals, may initiate a common cascade of events terminating in neurodegeneration... - Aluminum and copper in drinking water enhance inflammatory or oxidative events specifically in the brainAngelica Becaria
Department of Community and Environmental Medicine, Center for Occupational and Environmental Health Sciences, University of California, Irvine, Irvine, CA 92697-1825, USA
J Neuroimmunol 176:16-23. 2006..Results suggest that although Al or Cu may independently initiate inflammatory or oxidative events, they may function cooperatively to increase APP levels... - Aluminum and copper interact in the promotion of oxidative but not inflammatory events: implications for Alzheimer's diseaseAngelica Becaria
Department of Community and Environmental Medicine, Center for Occupational and Environmental Health, University of California Irvine, 92697 1820, USA
J Alzheimers Dis 5:31-8. 2003..Thus the ability of aluminum to promote inflammatory processes does not depend on an increase ROS production induced by interaction with transition metals... 
Inhaled ultrafine particulate matter affects CNS inflammatory processes and may act via MAP kinase signaling pathwaysM T Kleinman
Department of Community and Environmental Medicine, University of California Irvine, Irvine, CA 92697, USA
Toxicol Lett 178:127-30. 2008..This suggests that the signaling pathway by which these transcription factors are activated involves the activation of JNK...- Retardation of brain aging by chronic treatment with melatoninS C Bondy
Department of Community and Environmental Medicine, University of California, Irvine, 92697 1825, USA
Ann N Y Acad Sci 1035:197-215. 2004..This report summarizes the progress made in this area... - The chemistry of transition metals in relation to their potential role in neurodegenerative processesD Hamai
Department of Community and Environmental Medicine, Center for Occupational and Environmental Health, University of California, Irvine 92697 1820, USA
Curr Top Med Chem 1:541-51. 2001.... - Modulation of oxidative events by multivalent manganese complexes in brain tissueD Hamai
Department of Community and Environmental Medicine, Center for Occupational and Environmental Health, University of California, Irvine, Irvine, CA 92697 1825, USA
Free Radic Biol Med 31:763-8. 2001..Such findings of the potent effects of trace amounts of trivalent cations upon Mn2+-related free radical generation offer resolution of earlier disparate findings concerning the oxidative character of manganese... - Aluminum as a toxicantA Becaria
Department of Community and Environmental Medicine, Center for Occupational and Environmental Health Sciences, Irvine, CA 92697 1820, USA
Toxicol Ind Health 18:309-20. 2002..This review encompasses the general toxicology of aluminum with emphasis on the potential mechanisms by which it may accelerate the progression of chronic age-related neurodegenerative disorders... - Chronic exposure to low levels of aluminum alters cerebral cell signaling in response to acute MPTP administrationH Li
Department of Community and Environmental Medicine, Center for Occupational and Environmental Health, University of California, Irvine, California 92697 1825, USA
Toxicol Ind Health 23:515-24. 2007..However, no interaction in alteration of monoamine levels was found between Al and MPTP... - Differential toxicity of aluminum salts in human cell lines of neural origin: implications for neurodegenerationA Campbell
Department of Community and Environmental Medicine, Center for Occupational and Environmental Health, University of California, Irvine 92697-1820, USA
Neurotoxicology 22:63-71. 2001..It is possible that the principal neurotoxic target of the metal is glial and when these cells are in a compromised state, this may secondarily impact the neuronal population and thus eventually lead to neurodegeneration... - Developmental neurotoxicologyStephen C Bondy
Department of Community and Environmental Medicine, Center for Occupational and Environmental Health, University of California, Irvine, Irvine, California 92967 1820, USA
J Neurosci Res 81:605-12. 2005..The rate of brain aging may be influenced by events taking place in embryogenesis, following a prolonged asymptomatic period. The potential for appearance of adverse effects after prolonged latent periods is underscored... - Reduced basal levels and enhanced LPS response of IL-6 mRNA in aged miceK Sharman
Center for Occupational and Environmental Health, Department of Community and Environmental Medicine, University of California, Irvine, CA 92697-1825, USA
J Gerontol A Biol Sci Med Sci 56:B520-3. 2001..These data indicate that the aging process may predispose animals to an exaggerated and potentially harmful inflammatory response... - The significance of environmental factors in the etiology of Alzheimer's diseaseWilliam B Grant
12 Sir Francis Wyatt Place, Newport News, VA 23606 3660, USA
J Alzheimers Dis 4:179-89. 2002..Diet, aluminum, and viral infections may increase the prevalence of AD by eliciting inflammation, which may cause the neurological damage that results in AD... - The role of aluminum and copper on neuroinflammation and Alzheimer's diseaseArezoo Campbell
Western University of Health Sciences, Department of Pharmaceutical Sciences, Pomona, CA 91766, USA
J Alzheimers Dis 10:165-72. 2006..Since inflammatory events are reported to be upregulated in the AD brain, this may be one of the mechanisms by which the metals potentiate neurodegeneration... 
Particulate matter, oxidative stress and neurotoxicitySheba M J MohanKumar
Department of Pharmacology and Toxicology, Michigan State University, E Lansing, MI, USA
Neurotoxicology 29:479-88. 2008..These were recently presented at two 2007 symposia sponsored by the Society of Toxicology (Charlotte, NC) and the International Neurotoxicology Association (Monterey, CA)...- Incubation of nerve endings with a physiological concentration of Abeta1-42 activates CaV2.2(N-Type)-voltage operated calcium channels and acutely increases glutamate and noradrenaline releaseJoseph A Bobich
Department of Chemistry, Texas Christian University, Fort Worth, TX 76129, USA
J Alzheimers Dis 6:243-55. 2004....