Martha Campbell-Thompson

Summary

Affiliation: University of Florida
Country: USA

Publications

  1. pmc Network for Pancreatic Organ Donors with Diabetes (nPOD): developing a tissue biobank for type 1 diabetes
    Martha Campbell-Thompson
    Department of Pathology, Immunology and Laboratory Medicine, College of Medicine, University of Florida, Gainesville, FL 32610 0275, USA
    Diabetes Metab Res Rev 28:608-17. 2012
  2. doi request reprint Pancreatic adenocarcinoma patients with localised chronic severe pancreatitis show an increased number of single beta cells, without alterations in fractional insulin area
    M Campbell-Thompson
    Department of Pathology, Immunology, and Laboratory Medicine, University of Florida, 1600 SW Archer Road, PO Box 100275, Gainesville, FL 32610, USA
    Diabetologia 52:262-70. 2009
  3. doi request reprint Exendin-4 treatment of nonobese diabetic mice increases beta-cell proliferation and fractional insulin reactive area
    Song Xue
    Department of Pathology, University of Florida, Gainesville, FL 32610, USA
    J Diabetes Complications 24:163-7. 2010
  4. doi request reprint Soluble Flt-1 gene therapy ameliorates albuminuria but accelerates tubulointerstitial injury in diabetic mice
    Tomoki Kosugi
    Division of Nephrology, University of Florida, Gainesville, Florida, USA
    Am J Physiol Renal Physiol 298:F609-16. 2010
  5. ncbi request reprint Preclinical characterization of a recombinant adeno-associated virus type 1-pseudotyped vector demonstrates dose-dependent injection site inflammation and dissemination of vector genomes to distant sites
    Terence R Flotte
    Powell Gene Therapy Center, Department of Pediatrics, University of Florida, Gainesville, FL 32610, USA
    Hum Gene Ther 18:245-56. 2007
  6. ncbi request reprint Diabetic endothelial nitric oxide synthase knockout mice develop advanced diabetic nephropathy
    Takahiko Nakagawa
    Division of Nephrology, Hypertension and Transplantation, University of Florida, PO Box 100224, Gainesville, FL 32610 0224, USA
    J Am Soc Nephrol 18:539-50. 2007
  7. ncbi request reprint Alpha1-antitrypsin gene therapy modulates cellular immunity and efficiently prevents type 1 diabetes in nonobese diabetic mice
    Yuanqing Lu
    Department of Pharmaceutics, University of Florida, Gainesville, FL 32610, USA
    Hum Gene Ther 17:625-34. 2006
  8. pmc Sustained peripheral expression of transgene adiponectin offsets the development of diet-induced obesity in rats
    Stanislav Shklyaev
    Department of Molecular Genetics and Microbiology, Powell Gene Therapy Center, University of Florida, Gainesville, FL 32610 0266, USA
    Proc Natl Acad Sci U S A 100:14217-22. 2003
  9. ncbi request reprint The pivotal role of VEGF on glomerular macrophage infiltration in advanced diabetic nephropathy
    Waichi Sato
    Division of Nephrology, Department of Medicine, University of Florida, Gainesville, FL 32610 0224, USA
    Lab Invest 88:949-61. 2008
  10. ncbi request reprint Partial correction of the CFTR-dependent ABPA mouse model with recombinant adeno-associated virus gene transfer of truncated CFTR gene
    Christian Mueller
    Department of Pediatrics and Powell Gene Therapy Center, College of Medicine, University of Florida, Gainesville, FL, USA
    J Gene Med 10:51-60. 2008

Collaborators

Detail Information

Publications43

  1. pmc Network for Pancreatic Organ Donors with Diabetes (nPOD): developing a tissue biobank for type 1 diabetes
    Martha Campbell-Thompson
    Department of Pathology, Immunology and Laboratory Medicine, College of Medicine, University of Florida, Gainesville, FL 32610 0275, USA
    Diabetes Metab Res Rev 28:608-17. 2012
    ..These biospecimens are available to investigators for collaborative studies aimed at addressing questions related to T1D natural history and pathogenesis...
  2. doi request reprint Pancreatic adenocarcinoma patients with localised chronic severe pancreatitis show an increased number of single beta cells, without alterations in fractional insulin area
    M Campbell-Thompson
    Department of Pathology, Immunology, and Laboratory Medicine, University of Florida, 1600 SW Archer Road, PO Box 100275, Gainesville, FL 32610, USA
    Diabetologia 52:262-70. 2009
    ..We therefore tested the hypothesis that beta cell replication is observed in non-autoimmune human pancreatic disorders in which localised inflammation or elevated gastrin levels are present...
  3. doi request reprint Exendin-4 treatment of nonobese diabetic mice increases beta-cell proliferation and fractional insulin reactive area
    Song Xue
    Department of Pathology, University of Florida, Gainesville, FL 32610, USA
    J Diabetes Complications 24:163-7. 2010
    ....
  4. doi request reprint Soluble Flt-1 gene therapy ameliorates albuminuria but accelerates tubulointerstitial injury in diabetic mice
    Tomoki Kosugi
    Division of Nephrology, University of Florida, Gainesville, Florida, USA
    Am J Physiol Renal Physiol 298:F609-16. 2010
    ..These data suggest systemic overexpression of sFlt-1 will not likely be useful for treating diabetic nephropathy...
  5. ncbi request reprint Preclinical characterization of a recombinant adeno-associated virus type 1-pseudotyped vector demonstrates dose-dependent injection site inflammation and dissemination of vector genomes to distant sites
    Terence R Flotte
    Powell Gene Therapy Center, Department of Pediatrics, University of Florida, Gainesville, FL 32610, USA
    Hum Gene Ther 18:245-56. 2007
    ..The copy number of vector DNA in the blood and semen declined over time throughout the study. These two dose-dependent findings have served to guide to the design of a phase 1 human trial of rAAV1-AAT...
  6. ncbi request reprint Diabetic endothelial nitric oxide synthase knockout mice develop advanced diabetic nephropathy
    Takahiko Nakagawa
    Division of Nephrology, Hypertension and Transplantation, University of Florida, PO Box 100224, Gainesville, FL 32610 0224, USA
    J Am Soc Nephrol 18:539-50. 2007
    ..It was postulated that endothelial dysfunction should predict nephropathy and that correction of the dysfunction may prevent these important complications...
  7. ncbi request reprint Alpha1-antitrypsin gene therapy modulates cellular immunity and efficiently prevents type 1 diabetes in nonobese diabetic mice
    Yuanqing Lu
    Department of Pharmaceutics, University of Florida, Gainesville, FL 32610, USA
    Hum Gene Ther 17:625-34. 2006
    ..These results strongly suggest that rAAV1-mediated AAT gene therapy may be useful as a novel approach to prevent type 1 diabetes...
  8. pmc Sustained peripheral expression of transgene adiponectin offsets the development of diet-induced obesity in rats
    Stanislav Shklyaev
    Department of Molecular Genetics and Microbiology, Powell Gene Therapy Center, University of Florida, Gainesville, FL 32610 0266, USA
    Proc Natl Acad Sci U S A 100:14217-22. 2003
    ..These data show successful peripheral therapy in a clinically relevant model for human obesity and insulin resistance...
  9. ncbi request reprint The pivotal role of VEGF on glomerular macrophage infiltration in advanced diabetic nephropathy
    Waichi Sato
    Division of Nephrology, Department of Medicine, University of Florida, Gainesville, FL 32610 0224, USA
    Lab Invest 88:949-61. 2008
    ..In summary, NO negatively regulates VEGF-induced macrophage migration by inhibiting Flt-1 expression. The VEGF-endothelial NO uncoupling pathway might partially explain how VEGF causes glomerular disease in diabetes...
  10. ncbi request reprint Partial correction of the CFTR-dependent ABPA mouse model with recombinant adeno-associated virus gene transfer of truncated CFTR gene
    Christian Mueller
    Department of Pediatrics and Powell Gene Therapy Center, College of Medicine, University of Florida, Gainesville, FL, USA
    J Gene Med 10:51-60. 2008
    ..Gene therapy with rAAV5Delta-264CFTR attenuated the hyper-IgE response in this reproducible CF mouse model of ABPA, with systemic effects also evident in the cytokine response of stimulated splenocytes...
  11. pmc Ex vivo transduction and transplantation of bone marrow cells for liver gene delivery of alpha1-antitrypsin
    Hong Li
    Department of Pharmaceutics, University of Florida, Gainesville, FL, USA
    Mol Ther 18:1553-8. 2010
    ..These results demonstrated that rAAV vector-mediated BM cell-based liver gene therapy is feasible for the treatment of AAT deficiency and implies a novel therapy for the treatment of liver diseases...
  12. ncbi request reprint Alpha1-antitrypsin protects beta-cells from apoptosis
    Bin Zhang
    Department of Pharmaceutics, University of Florida, Gainsville, FL 32610, USA
    Diabetes 56:1316-23. 2007
    ..These results propose a novel biological function for this molecule and suggest it may represent an effective candidate for attempts seeking to prevent or reverse type 1 diabetes...
  13. ncbi request reprint Adeno-associated virus-mediated IL-10 gene therapy inhibits diabetes recurrence in syngeneic islet cell transplantation of NOD mice
    Y Clare Zhang
    Department of Pathology, University of Florida, 1600 SW Archer Road, Gainesville, FL 32610 0275, USA
    Diabetes 52:708-16. 2003
    ..These studies support the utility of immunoregulatory cytokine gene therapy delivered by rAAV for preventing autoimmune disease recurrence in transplant-based therapies for type 1 diabetes...
  14. pmc Alpha-1 antitrypsin protein and gene therapies decrease autoimmunity and delay arthritis development in mouse model
    Christian Grimstein
    Department of Pharmaceutics, University of Florida, Gainesville, FL 32610, USA
    J Transl Med 9:21. 2011
    ..In the present study we investigated the feasibility of hAAT monotherapy for the treatment of chronic arthritis in collagen-induced arthritis (CIA), a mouse model of rheumatoid arthritis (RA)...
  15. pmc Diabetic eNOS-knockout mice develop accelerated retinopathy
    Qiuhong Li
    Department of Ophthalmology, College of Medicine, University of Florida, Gainesville, Florida 32610 0284, USA
    Invest Ophthalmol Vis Sci 51:5240-6. 2010
    ..This study was undertaken to determine the role of eNOS in the development of diabetic retinopathy (DR), by investigating the functional consequences of its deficiency in the diabetic state...
  16. pmc Endothelial von Willebrand factor release due to eNOS deficiency predisposes to thrombotic microangiopathy in mouse aging kidney
    Takahiro Nakayama
    Division of Nephrology, University of Florida, Gainesville, Florida, USA
    Am J Pathol 176:2198-208. 2010
    ..A lack of nitric oxide likely contributed to the release of vWF, leading to thrombus formation in this model...
  17. ncbi request reprint Therapeutic level of functional human alpha 1 antitrypsin (hAAT) secreted from murine muscle transduced by adeno-associated virus (rAAV1) vector
    Yuanqing Lu
    Department of Pharmaceutics, University of Florida College of Pharmacy, Gainesville, FL 32610, USA
    J Gene Med 8:730-5. 2006
    ..These results provide strong support for the functionality of AAT in ongoing clinical studies of muscle-directed AAT gene therapy...
  18. pmc Selective stimulation of VEGFR2 accelerates progressive renal disease
    Waichi Sato
    Division of Nephrology, University of Florida, Gainesville, Florida, USA
    Am J Pathol 179:155-66. 2011
    ..In conclusion, prestimulation of VEGFR2 can potentiate subsequent renal injury in mice, an effect enhanced in the setting of nitric oxide deficiency...
  19. ncbi request reprint In vivo post-transcriptional gene silencing of alpha-1 antitrypsin by adeno-associated virus vectors expressing siRNA
    Pedro E Cruz
    Department of Pediatrics, University of Florida, Gainesville, FL, USA
    Lab Invest 87:893-902. 2007
    ..The rAAV8-3X-siRNA vector may hold promise as a potential therapy for patients with AAT liver disease...
  20. pmc Recombinant AAV serotype and capsid mutant comparison for pulmonary gene transfer of alpha-1-antitrypsin using invasive and noninvasive delivery
    Rejean Liqun Wang
    Department of Pediatrics and Powell Gene Therapy Center, University of Florida, Gainesville, Florida, USA
    Mol Ther 17:81-7. 2009
    ..Overall, rAAV8 was the most promising vector for the future application in gene therapy of pulmonary diseases such as AAT deficiency-related emphysema...
  21. pmc N-glycosylation augmentation of the cystic fibrosis epithelium improves Pseudomonas aeruginosa clearance
    Ashley T Martino
    Department of Molecular Genetics and Microbiology, College of Medicine, University of Florida, Gainesville, Florida, USA
    Am J Respir Cell Mol Biol 44:824-30. 2011
    ..Augmenting N-glycosylation to attenuate colonization of P. aeruginosa in CF airways reveals a new therapeutic avenue for a hallmark disease condition in CF...
  22. pmc Gene delivery to intestinal epithelial cells in vitro and in vivo with recombinant adeno-associated virus types 1, 2 and 5
    Steven Polyak
    Division of Gastroenterology, Department of Medicine, University of Florida, Gainesville, FL 32610, USA
    Dig Dis Sci 53:1261-70. 2008
    ....
  23. pmc Analysis of steroid hormone effects on xenografted human NF1 tumor schwann cells
    Hua Li
    Department of Molecular Genetics and Microbiology, College of Medicine, University of Florida, Gainesville, FL, USA
    Cancer Biol Ther 10:758-64. 2010
    ..This suggests that anti-estrogen or anti-progesterone therapies may be worth considering for specific NF1 neurofibromas and MPNSTs...
  24. doi request reprint Combination of alpha-1 antitrypsin and doxycycline suppresses collagen-induced arthritis
    Christian Grimstein
    Department of Pharmaceutics, University of Florida, Gainesville, FL 32610, USA
    J Gene Med 12:35-44. 2010
    ..In order to develop a new treatment option, the present study employs a gene therapy-based combination therapy using doxycycline and human alpha-1 antitrypsin (hAAT)...
  25. pmc Glycogen storage disease type Ia in canines: a model for human metabolic and genetic liver disease
    Andrew Specht
    Department of Small Animal Clinical Sciences, University of Florida, Gainesville, FL 32610, USA
    J Biomed Biotechnol 2011:646257. 2011
    ..Despite these challenges, the canine model of GSDIa should continue to provide valuable information about the potential for generating curative therapies for GSDIa as well as other genetic hepatic diseases...
  26. ncbi request reprint Efficient hepatic delivery and expression from a recombinant adeno-associated virus 8 pseudotyped alpha1-antitrypsin vector
    Thomas J Conlon
    Department of Pediatrics and Powell Gene Therapy Center, University of Florida, Gainesville, FL 32608, USA
    Mol Ther 12:867-75. 2005
    ..Therefore, pseudotyped AAV8 provides a vehicle to infect a high percentage of hepatocytes stably and thereby express therapeutic molecules to modify AAT PiZ transcripts...
  27. ncbi request reprint In vitro studies of steroid hormones in neurofibromatosis 1 tumors and Schwann cells
    Lauren Fishbein
    Department of Molecular Genetics and Microbiology, UF College of Medicine, University of Florida, Gainesville, FL 32610, USA
    Mol Carcinog 46:512-23. 2007
    ..Our data suggest that steroid hormones can directly influence neurofibroma initiation or progression by acting through their cognate receptor, but that these effects may only apply to a subset of tumors, in either gender...
  28. doi request reprint Exendin-4 therapy in NOD mice with new-onset diabetes increases regulatory T cell frequency
    Song Xue
    Department of Pathology, University of Florida, Florida 32010, USA
    Ann N Y Acad Sci 1150:152-6. 2008
    ..Taken collectively, these data suggest that in addition to its potential effects on beta cell proliferation, Ex-4 may also act as a regulator of the immune response...
  29. pmc Diabetes acceleration or prevention by a coxsackievirus B4 infection: critical requirements for both interleukin-4 and gamma interferon
    David V Serreze
    Department of Pathology, University of Florida, Box 100275 JHMHC, 1600 SW Archer Rd, Gainesville, FL 32610, USA
    J Virol 79:1045-52. 2005
    ..The protective mechanism against diabetes elicited in NOD mice infected with CVB4 prior to the development of a critical threshold level of insulitis requires neither IL-4 nor IFN-gamma...
  30. ncbi request reprint Murine antithymocyte globulin therapy alters disease progression in NOD mice by a time-dependent induction of immunoregulation
    Greg Simon
    Department of Pathology, University of Florida, 1600 SW Archer Rd, Gainesville, FL 32610, USA
    Diabetes 57:405-14. 2008
    ....
  31. pmc Gel-mediated delivery of AAV1 vectors corrects ventilatory function in Pompe mice with established disease
    Cathryn S Mah
    Powell Gene Therapy Center, University of Florida, Gainesville, Florida 32610, USA
    Mol Ther 18:502-10. 2010
    ..These results demonstrate that gel-mediated delivery of rAAV2/1 vectors can significantly augment ventilatory function at initial and late phases of disease in a model of muscular dystrophy...
  32. pmc Successful production of pseudotyped rAAV vectors using a modified baculovirus expression system
    Erik Kohlbrenner
    Powell Gene Therapy Center, Division of Cellular and Molecular Therapy, Department of Pediatrics, University of Florida, Gainesville, FL 32610, USA
    Mol Ther 12:1217-25. 2005
    ..The redesigned baculovirus system improves our capacity for rAAV manufacturing by making this production platform more applicable to other existing serotypes...
  33. ncbi request reprint p53 regulates FAK expression in human tumor cells
    Vita M Golubovskaya
    Department of Surgery, University of Florida, Gainesville, USA
    Mol Carcinog 47:373-82. 2008
    ..In addition, tumor-derived missense mutations in the DNA-binding domain (R282, R249, and V173) also led to increased FAK promoter activity. Thus, the present data show that p53 can regulate FAK expression during tumorigenesis...
  34. pmc Salivary PYY: a putative bypass to satiety
    Andrés Acosta
    Pediatrics, University of Florida, Gainesville, Florida, United States of America
    PLoS ONE 6:e26137. 2011
    ..Thus this study provides evidence for new functions of the previously characterized gut peptide PYY(3-36) suggesting a potential simple and efficient alternative therapeutic approach for the treatment of obesity...
  35. pmc Adeno-associated virus-mediated correction of a canine model of glycogen storage disease type Ia
    David A Weinstein
    Glycogen Storage Disease Program, Division of Pediatric Endocrinology, Department of Pediatrics, University of Florida, Gainesville, FL 32610, USA
    Hum Gene Ther 21:903-10. 2010
    ..These results demonstrate that delivery of rAAV vectors can mediate significant correction of the GSDIa phenotype and that gene transfer may be a promising alternative therapy for this disease and other genetic diseases of the liver...
  36. ncbi request reprint Expression of estrogen receptor (ER) subtypes and ERbeta isoforms in colon cancer
    M Campbell-Thompson
    Department of Medicine, College of Medicine, University of Florida, Gainesville 32610, USA
    Cancer Res 61:632-40. 2001
    ..This information suggests that activation of ERbeta-mediated processes in the superficial colonic epithelium may have a role in the preventive effects observed for female gender and ERT usage...
  37. ncbi request reprint 17Beta-estradiol modulates gastroduodenal preneoplastic alterations in rats exposed to the carcinogen N-methyl-N'-nitro-nitrosoguanidine
    M Campbell-Thompson
    Department of Medicine, College of Medicine, University of Florida, Gainesville 32610, USA
    Endocrinology 140:4886-94. 1999
    ..These results explain, in part, a potential pathway through which protective effects of estrogens on chemical carcinogenesis are mediated in the upper gastrointestinal tract...
  38. ncbi request reprint Immunolocalization of estrogen receptor alpha and beta in gastric epithelium and enteric neurons
    M Campbell-Thompson
    Department of Medicine, College of Medicine, University of Florida, Gainesville, Florida 32610 0267, USA
    J Endocrinol 171:65-73. 2001
    ..Our findings imply that direct regulation of multiple cell types by estrogens may contribute to the modulation of gastric functions that have been recognized during the estrous cycle and between the sexes...
  39. ncbi request reprint Ectopic expression of Wnt10b decreases adiposity and improves glucose homeostasis in obese rats
    George Aslanidi
    Department of Pediatrics, University of Florida, Gainesville, FL 32610, USA
    Am J Physiol Endocrinol Metab 293:E726-36. 2007
    ....
  40. ncbi request reprint Distinct expression and activity profiles of largemouth bass (Micropterus salmoides) estrogen receptors in response to estradiol and nonylphenol
    Tara Sabo-Attwood
    Department of Pharmacology and Therapeutics, University of Florida, PO Box 110885, Gainesville, Florida 32611, USA
    J Mol Endocrinol 39:223-37. 2007
    ..Results from these studies collectively reveal the differential response of fish ER isotypes in response to xenoestrogens...
  41. pmc Enhanced expression of Pctk1, Tcf12 and Ccnd1 in hippocampus of rats: Impact on cognitive function, synaptic plasticity and pathology
    Ke Wu
    Department of Molecular Genetics and Microbiology, University of Florida, Gainesville, FL 32610, USA
    Neurobiol Learn Mem 97:69-80. 2012
    ..In contrast, the learning and memory deficits in Tcf12 animals are likely due to neuropathology associated with Tcf12 gene expression...
  42. pmc Lowering blood pressure blocks mesangiolysis and mesangial nodules, but not tubulointerstitial injury, in diabetic eNOS knockout mice
    Tomoki Kosugi
    Division of Nephrology, University of Florida, Gainesville, Florida, USA
    Am J Pathol 174:1221-9. 2009
    ..This study could provide insights into the pathogenesis of advanced diabetic nephropathy in the presence of endothelial dysfunction...
  43. ncbi request reprint Adeno-associated virus transduction of islets with interleukin-4 results in impaired metabolic function in syngeneic marginal islet mass transplantation
    Y Clare Zhang
    Department of Pathology, University of Florida, 1600 SW Archer Road, Gainesville, FL 32610, USA
    Transplantation 74:1184-6. 2002
    ..Islet expression of IL-4 led to impaired metabolic function in mice receiving a marginal mass of syngeneic islets...