Clifton Callaway

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. ncbi request reprint Early coronary angiography and induced hypothermia are associated with survival and functional recovery after out-of-hospital cardiac arrest
    Clifton W Callaway
    University of Pittsburgh, Pittsburgh, PA, United States Electronic address
    Resuscitation 85:657-63. 2014
  2. pmc Mobile phone text message intervention to reduce binge drinking among young adults: study protocol for a randomized controlled trial
    Brian Suffoletto
    Department of Emergency Medicine, University of Pittsburgh, Iroquois Building, Pittsburgh, PA 15261, USA
    Trials 14:93. 2013
  3. doi request reprint Epinephrine for cardiac arrest
    Clifton W Callaway
    Department of Emergency Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA
    Curr Opin Cardiol 28:36-42. 2013
  4. ncbi request reprint Waveform analysis of ventricular fibrillation to predict defibrillation
    Clifton W Callaway
    University of Pittsburgh, School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    Curr Opin Crit Care 11:192-9. 2005
  5. pmc Receiving hospital characteristics associated with survival after out-of-hospital cardiac arrest
    Clifton W Callaway
    Department of Emergency Medicine, University of Pittsburgh, Pittsburgh, PA, USA
    Resuscitation 81:524-9. 2010
  6. ncbi request reprint Current & future direction for the resuscitation of cardiac arrest patients
    Clifton W Callaway
    University of Pittsburgh, USA
    JEMS 29:suppl 14-22. 2004
  7. pmc Brain-derived neurotrophic factor does not improve recovery after cardiac arrest in rats
    Clifton W Callaway
    Department of Emergency Medicine, Safar Center for Resuscitation Research, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Neurosci Lett 445:103-7. 2008
  8. ncbi request reprint Hypothermia after cardiac arrest does not alter serum inflammatory markers
    Clifton W Callaway
    Department of Emergency Medicine, University of Pittsburgh, Pittsburgh, PA, USA
    Crit Care Med 36:2607-12. 2008
  9. ncbi request reprint Usefulness of vasopressin administered with epinephrine during out-of-hospital cardiac arrest
    Clifton W Callaway
    Department of Emergency Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Am J Cardiol 98:1316-21. 2006
  10. ncbi request reprint Time to administration of epinephrine and outcome after in-hospital cardiac arrest with non-shockable rhythms: retrospective analysis of large in-hospital data registry
    Michael W Donnino
    Department of Emergency Medicine, Beth Israel Deaconess Medical Center, 1 Deaconess Road, Boston, W CC 2, MA, 02215, USA Department of Medicine, Division of Critical Care, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, MA, 02215, USA
    BMJ 348:g3028. 2014

Research Grants

  1. Hypothermia and Gene Expression After Cardiac Arrest
    Clifton Callaway; Fiscal Year: 2002
  2. BRAIN ISCHEMIA AND MAP KINASE ACTIVATION
    Clifton Callaway; Fiscal Year: 2003
  3. Hypothermia and Gene Expression After Cardiac Arrest
    Clifton Callaway; Fiscal Year: 2003
  4. Hypothermia and Gene Expression After Cardiac Arrest
    Clifton Callaway; Fiscal Year: 2004
  5. Hypothermia and Gene Expression After Cardiac Arrest
    Clifton Callaway; Fiscal Year: 2003
  6. Hypothermia and Gene Expression After Cardiac Arrest
    Clifton Callaway; Fiscal Year: 2005
  7. Pittsburgh Resuscitation Network
    Clifton Callaway; Fiscal Year: 2007

Detail Information

Publications69

  1. ncbi request reprint Early coronary angiography and induced hypothermia are associated with survival and functional recovery after out-of-hospital cardiac arrest
    Clifton W Callaway
    University of Pittsburgh, Pittsburgh, PA, United States Electronic address
    Resuscitation 85:657-63. 2014
    ..We measured the association of early (≤24h after arrival) coronary angiography, reperfusion, and induced hypothermia with favorable outcome after OHCA...
  2. pmc Mobile phone text message intervention to reduce binge drinking among young adults: study protocol for a randomized controlled trial
    Brian Suffoletto
    Department of Emergency Medicine, University of Pittsburgh, Iroquois Building, Pittsburgh, PA 15261, USA
    Trials 14:93. 2013
    ..Efficacy of SMS programs to reduce binge drinking remains unknown...
  3. doi request reprint Epinephrine for cardiac arrest
    Clifton W Callaway
    Department of Emergency Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA
    Curr Opin Cardiol 28:36-42. 2013
    ..However, the dose, timing and indications for epinephrine use are based on limited animal data. Recent studies question whether epinephrine provides any overall benefit for patients...
  4. ncbi request reprint Waveform analysis of ventricular fibrillation to predict defibrillation
    Clifton W Callaway
    University of Pittsburgh, School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    Curr Opin Crit Care 11:192-9. 2005
    ..Quantitative analysis of the ventricular fibrillation waveform may distinguish coarse ventricular fibrillation from fine ventricular fibrillation, allowing more appropriate delivery of rescue shocks...
  5. pmc Receiving hospital characteristics associated with survival after out-of-hospital cardiac arrest
    Clifton W Callaway
    Department of Emergency Medicine, University of Pittsburgh, Pittsburgh, PA, USA
    Resuscitation 81:524-9. 2010
    ..This study examined whether survival to hospital discharge was related to receiving hospital characteristics, including bed number, capability of performing cardiac catheterization and hospital volume of OOHCA cases...
  6. ncbi request reprint Current & future direction for the resuscitation of cardiac arrest patients
    Clifton W Callaway
    University of Pittsburgh, USA
    JEMS 29:suppl 14-22. 2004
  7. pmc Brain-derived neurotrophic factor does not improve recovery after cardiac arrest in rats
    Clifton W Callaway
    Department of Emergency Medicine, Safar Center for Resuscitation Research, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Neurosci Lett 445:103-7. 2008
    ..These data suggest that increased BDNF levels are not sufficient to explain the beneficial effects of mild hypothermia after cardiac arrest, and that exogenous BDNF administration does not increase extracellular ERK signaling...
  8. ncbi request reprint Hypothermia after cardiac arrest does not alter serum inflammatory markers
    Clifton W Callaway
    Department of Emergency Medicine, University of Pittsburgh, Pittsburgh, PA, USA
    Crit Care Med 36:2607-12. 2008
    ..This study tested whether therapeutic hypothermia altered levels of inflammatory markers in serum...
  9. ncbi request reprint Usefulness of vasopressin administered with epinephrine during out-of-hospital cardiac arrest
    Clifton W Callaway
    Department of Emergency Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Am J Cardiol 98:1316-21. 2006
    ..Survival duration for subjects admitted to the hospital did not differ between groups. In conclusion, vasopressin administered with epinephrine does not increase the rate of return of spontaneous circulation...
  10. ncbi request reprint Time to administration of epinephrine and outcome after in-hospital cardiac arrest with non-shockable rhythms: retrospective analysis of large in-hospital data registry
    Michael W Donnino
    Department of Emergency Medicine, Beth Israel Deaconess Medical Center, 1 Deaconess Road, Boston, W CC 2, MA, 02215, USA Department of Medicine, Division of Critical Care, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, MA, 02215, USA
    BMJ 348:g3028. 2014
    ..To determine if earlier administration of epinephrine (adrenaline) in patients with non-shockable cardiac arrest rhythms is associated with increased return of spontaneous circulation, survival, and neurologically intact survival...
  11. pmc A critical assessment of the out-of-hospital trauma triage guidelines for physiologic abnormality
    Craig D Newgard
    Department of Emergency Medicine, Center for Policy and Research in Emergency Medicine, Oregon Health and Science University, Portland, Oregon, USA
    J Trauma 68:452-62. 2010
    ..We assessed whether more restrictive physiologic criteria would improve the specificity of this triage step without missing high-risk patients...
  12. ncbi request reprint Immediate defibrillation versus interventions first in a swine model of prolonged ventricular fibrillation
    James J Menegazzi
    Department of Emergency Medicine, 230 McKee Place, Suite 400, Pittsburgh, PA 15213, USA
    Resuscitation 59:261-70. 2003
    ..We also sought to determine the predictive value of the ScE in determining post-shock outcomes...
  13. ncbi request reprint Dynamic nature of electrocardiographic waveform predicts rescue shock outcome in porcine ventricular fibrillation
    Christopher B Lightfoot
    Department of Emergency Medicine, Center for Emergency Medicine of Western Pennsylvania, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Ann Emerg Med 42:230-41. 2003
    ..This study examined whether the scaling exponent could predict rescue shock success and whether unsuccessful rescue shocks altered the structure of the ventricular fibrillation waveform and the responsiveness to subsequent rescue shocks...
  14. doi request reprint Interruptions in cardiopulmonary resuscitation from paramedic endotracheal intubation
    Henry E Wang
    Department of Emergency Medicine, University of Pittsburgh, Pittsburgh, PA
    Ann Emerg Med 54:645-652.e1. 2009
    ..We quantified the frequency and duration of CPR chest compression interruptions associated with paramedic endotracheal intubation efforts during out-of-hospital cardiopulmonary arrest...
  15. ncbi request reprint A randomized comparison of manual, mechanical and high-impulse chest compression in a porcine model of prolonged ventricular fibrillation
    Amy E Betz
    Department of Emergency Medicine, University of Pittsburgh School of Medicine, 230 McKee Place, Suite 400, Pittsburgh, PA 15213, USA
    Resuscitation 69:495-501. 2006
    ..We hypothesized that HI (very rapid acceleration of the down-stroke) would produce greater CPPs than MAN or MECH, and that HI would also produce a higher rate of ROSC...
  16. pmc Emergency medical services intervals and survival in trauma: assessment of the "golden hour" in a North American prospective cohort
    Craig D Newgard
    Center for Policy and Research in Emergency Medicine, Department of Emergency Medicine, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97239 3098, USA
    Ann Emerg Med 55:235-246.e4. 2010
    ..We evaluate the association between emergency medical services (EMS) intervals and mortality among trauma patients with field-based physiologic abnormality...
  17. doi request reprint Prehospital serum lactate as a predictor of outcomes in trauma patients: a retrospective observational study
    Francis Guyette
    Department of Emergency Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    J Trauma 70:782-6. 2011
    ..Lactate is associated with morbidity and mortality; however, the value of prehospital lactate (pLA) is unknown. Our objective was to determine whether pLA improves identification of mortality and morbidity independent of vital signs...
  18. ncbi request reprint Hypothermia and ERK activation after cardiac arrest
    Brian J D'Cruz
    Department of Emergency Medicine, 230 McKee Place, Suite 400, Pittsburgh, PA 15213, USA
    Brain Res 1064:108-18. 2005
    ..These results suggest that hypothermia-induced improvement in outcomes does not require ERK activation...
  19. pmc A trial of an impedance threshold device in out-of-hospital cardiac arrest
    Tom P Aufderheide
    Department of Emergency Medicine, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    N Engl J Med 365:798-806. 2011
    ..Previous studies have suggested that the use of an ITD during CPR may improve survival rates after cardiac arrest...
  20. doi request reprint Near-infrared spectroscopy in post-cardiac arrest patients undergoing therapeutic hypothermia
    Brian Suffoletto
    Department of Emergency Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States
    Resuscitation 83:986-90. 2012
    ..To investigate the relationship between tissue oxygen saturation during a vascular occlusion test with systemic hemodynamics, central and peripheral skin temperature in patients resuscitated from cardiac arrest...
  21. doi request reprint Body temperature changes are associated with outcomes following in-hospital cardiac arrest and return of spontaneous circulation
    Brian Suffoletto
    University of Pittsburgh, Pittsburgh, PA, United States
    Resuscitation 80:1365-70. 2009
    ..We tested the hypothesis that adults who experience temperature lability in the first 24h have worse outcomes compared with those who maintain normothermia...
  22. ncbi request reprint Angular velocity: a new method to improve prediction of ventricular fibrillation duration
    Lawrence D Sherman
    Department of Emergency Medicine, University of Pittsburg School of Medicine, Pittsburgh, PA 15213, USA
    Resuscitation 60:79-90. 2004
    ..The combination of ScE and AV can be used in developing strategies for the treatment of VF during the different clinical phases of VF...
  23. pmc Post-resuscitation hemodynamics and relationship to the duration of ventricular fibrillation
    James J Menegazzi
    Department of Emergency Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Resuscitation 78:355-8. 2008
    ..We sought to characterize the time-course of these patterns, and to determine whether these differed based on duration of the VF insult...
  24. doi request reprint Method of cold saline storage for prehospital induced hypothermia
    Mitch Kampmeyer
    Department of Emergency Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Prehosp Emerg Care 13:81-4. 2009
    ..The aim of this study was to determine whether a standard commercial cooler can maintain two 1-L normal saline solution (NSS) bags below 4 degrees C in three different environments...
  25. doi request reprint Summary of NIH Medical-Surgical Emergency Research Roundtable held on April 30 to May 1, 2009
    Amy H Kaji
    Department of Emergency Medicine, Harbor UCLA Medical Center, 1000 W Carson Street, Box 21, Torrance, CA 90509 2910, USA
    Ann Emerg Med 56:522-37. 2010
    ....
  26. pmc Outcomes of a hospital-wide plan to improve care of comatose survivors of cardiac arrest
    Jon C Rittenberger
    Department of Emergency Medicine, University of Pittsburgh, United States
    Resuscitation 79:198-204. 2008
    ..We implemented a series of process interventions designed to increase TH use and improve outcomes in patients successfully resuscitated from out-of-hospital cardiac arrest (OHCA) or in-hospital cardiac arrest (IHCA)...
  27. doi request reprint Risk of cardiopulmonary arrest after acute respiratory compromise in hospitalized patients
    Henry E Wang
    Department of Emergency Medicine, University of Pittsburgh, 230 McKee Place, Suite 400, Pittsburgh, PA 15213, USA
    Resuscitation 79:234-40. 2008
    ..We determined the characteristics and clinical course of hospitalized patients experiencing ARC as well as their risk of developing subsequent CPA...
  28. pmc Effect of real-time feedback during cardiopulmonary resuscitation outside hospital: prospective, cluster-randomised trial
    David Hostler
    Department of Emergency Medicine, University of Pittsburgh, 3600 Forbes Ave, Suite 400A, Pittsburgh, PA 15261, USA
    BMJ 342:d512. 2011
    ..To investigate whether real-time audio and visual feedback during cardiopulmonary resuscitation outside hospital increases the proportion of subjects who achieved prehospital return of spontaneous circulation...
  29. doi request reprint High-dose diazepam facilitates core cooling during cold saline infusion in healthy volunteers
    David Hostler
    University of Pittsburgh, Department of Emergency Medicine, Pittsburgh, PA 15213, USA
    Appl Physiol Nutr Metab 34:582-6. 2009
    ....
  30. pmc Association between clinical examination and outcome after cardiac arrest
    Jon C Rittenberger
    University of Pittsburgh, Department of Emergency Medicine, Pittsburgh, PA 15261, USA
    Resuscitation 81:1128-32. 2010
    ..We measured the association between clinical examination findings at hospital arrival, 24, and 72 h after cardiac arrest in a modern intensive care unit setting...
  31. pmc Increased survival after EMS witnessed cardiac arrest. Observations from the Resuscitation Outcomes Consortium (ROC) Epistry-Cardiac arrest
    David Hostler
    University of Pittsburgh, Department of Emergency Medicine, Suite 400A, Pittsburgh, PA 15261, USA
    Resuscitation 81:826-30. 2010
    ..We examined EMS witnessed OHCA from the Resuscitation Outcomes Consortium (ROC) to determine the effect of EMS witnessed vs. bystander witnessed and unwitnessed OHCA...
  32. pmc Mild hypothermia alters midazolam pharmacokinetics in normal healthy volunteers
    David Hostler
    Department of Emergency Medicine, Emergency Responder Human Performance Laboratory, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Drug Metab Dispos 38:781-8. 2010
    ..Future studies in patients who receive lower levels and a longer duration of hypothermia are warranted...
  33. pmc Survival of verapamil-poisoned rats treated with triiodothyronine
    Michael J Lynch
    Department of Emergency Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
    J Med Toxicol 6:94-9. 2010
    ..Despite significant variability in toxicity among individual animals, no statistically significant difference in survival time, heart rate, or MAP was found between groups treated with T3 and those receiving saline...
  34. doi request reprint The effect of adenosine A1 receptor antagonism on return of spontaneous circulation and short-term survival in prolonged ventricular fibrillation
    Timothy J Mader
    Department of Emergency Medicine, Baystate Medical Center Tufts University School of Medicine, Boston, Massachusetts, USA
    Prehosp Emerg Care 12:352-8. 2008
    ..We have previously shown that ADO A1 receptor (ADOA1R) antagonism hastens the time-dependent decay in VF waveform morphology during the circulatory phase of cardiac arrest...
  35. ncbi request reprint Increased chest compression to ventilation ratio improves delivery of CPR
    David Hostler
    University of Pittsburgh, Pittsburgh, United States
    Resuscitation 74:446-52. 2007
    ..We evaluated a protocol change from the recommended C:V ratio of 15:2-30:2 during CPR in our municipal emergency medical system...
  36. ncbi request reprint Differential effects of out-of-hospital interventions on short- and long-term survival after cardiopulmonary arrest
    Henry E Wang
    Department of Emergency Medicine, University of Pittsburgh School of Medicine, 230 McKee Place, Suite 400, Pittsburgh, PA 15213, USA
    Resuscitation 67:69-74. 2005
    ....
  37. ncbi request reprint Inter-rater reliability for witnessed collapse and presence of bystander CPR
    Jon C Rittenberger
    Department of Emergency Medicine, University of Pittsburgh, 230 McKee Place, Suite 400, Pittsburgh, PA 15213, USA
    Resuscitation 70:410-5. 2006
    ..We sought to determine the inter-rater reliability for different methods of ascertaining and defining witnessed collapse and performance of bystander CPR...
  38. ncbi request reprint Ventricular fibrillation scaling exponent can guide timing of defibrillation and other therapies
    James J Menegazzi
    Department of Emergency Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Circulation 109:926-31. 2004
    ..The scaling exponent (ScE) of the ventricular fibrillation (VF) waveform correlates with duration of VF and predicts defibrillation outcome. We compared 4 therapeutic approaches to the treatment of VF of various durations...
  39. ncbi request reprint Thrombin-antithrombin appearance in out-of-hospital cardiac arrest
    David Hostler
    Department of Emergency Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Prehosp Emerg Care 11:9-13. 2007
    ..We characterized the prevalence of thrombogenesis during OOHCA by measuring plasma levels of thrombin-antithrombin complexes (TAT)...
  40. ncbi request reprint Association of delay to first intervention with return of spontaneous circulation in a swine model of cardiac arrest
    Jon C Rittenberger
    University of Pittsburgh, Department of Emergency Medicine, Pittsburgh, PA 15213, USA
    Resuscitation 73:154-60. 2007
    ..We sought to determine the duration of circulatory arrest after which maximal drug treatment and a rescue shock would fail to achieve return of spontaneous circulation (ROSC)...
  41. ncbi request reprint Admission hypothermia and outcome after major trauma
    Henry E Wang
    Department of Emergency Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Crit Care Med 33:1296-301. 2005
    ..The goal of this study was to evaluate the independent association between admission hypothermia and mortality after major trauma, with adjustment for clinical confounders...
  42. pmc Predictors of ROSC in witnessed aeromedical cardiac arrests
    Jon C Rittenberger
    Department of Emergency Medicine, University of Pittsburgh, Pittsburgh, PA, United States
    Resuscitation 76:43-6. 2008
    ..We completed a retrospective analysis of aeromedical patient care records in order to describe the pre-arrest characteristics and the return of spontaneous circulation (ROSC) in this subset of patients...
  43. ncbi request reprint Feasibility of external cranial cooling during out-of-hospital cardiac arrest
    Clifton W Callaway
    Department of Emergency Medicine, University of Pittsburgh, 230 McKee Place, Suite 400, Pittsburgh, PA 15213, USA
    Resuscitation 52:159-65. 2002
    ..However, most cardiac arrest victims are spontaneously mildly hypothermic and preventing rewarming may provide some of the desired benefits of cerebral hypothermia...
  44. ncbi request reprint Core temperature cooling in healthy volunteers after rapid intravenous infusion of cold and room temperature saline solution
    Tracy M Moore
    Department of Emergency Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Ann Emerg Med 51:153-9. 2008
    ..9% saline solution during 30 minutes to healthy subjects (aged 27 [standard deviation (SD) 4] years) will reduce core body temperature to the therapeutic range of 33 degrees C to 35 degrees C (91.4 degrees F to 95 degrees F)...
  45. ncbi request reprint Hyponatremia in runners requiring on-site medical treatment at a single marathon
    Margaret Hsieh
    Department of Emergency Medicine, University of Pittsburgh, Pittsburgh, PA, USA
    Med Sci Sports Exerc 34:185-9. 2002
    ....
  46. ncbi request reprint Vasopressin administered with epinephrine is associated with a return of a pulse in out-of-hospital cardiac arrest
    Francis X Guyette
    Department of Emergency Medicine, University of Pittsburgh School of Medicine, 230 McKee Place, Suite 400, Pittsburgh, PA 15213, USA
    Resuscitation 63:277-82. 2004
    ..This study examined local experience with the combination of epinephrine and vasopressin administration...
  47. pmc The availability and use of out-of-hospital physiologic information to identify high-risk injured children in a multisite, population-based cohort
    Craig D Newgard
    Center for Policy and Research in Emergency Medicine, Department of Emergency Medicine, Oregon Health and Science University, Portland, Oregon 97239 3098, USA
    Prehosp Emerg Care 13:420-31. 2009
    ....
  48. pmc Neurological and functional status following cardiac arrest: method and tool utility
    Ketki D Raina
    University of Pittsburgh, School of Health and Rehabilitation Sciences, Department of Occupational Therapy, 5012 Forbes Tower, Pittsburgh, PA 15260, USA
    Resuscitation 79:249-56. 2008
    ..This study examined the relationships among the CPC and measures of global disability and QOL at discharge from the hospital and at 1 month after CA...
  49. ncbi request reprint Rescue shock outcomes during out-of-hospital cardiac arrest
    Bruce M Lo
    Department of Emergency Medicine, University of Pittsburgh, Pittsburgh, PA, USA
    Resuscitation 75:469-75. 2007
    ..The purpose of this study is to describe rescue shock outcomes in a single system using a specific defibrillation protocol...
  50. doi request reprint A mobile phone text message program to measure oral antibiotic use and provide feedback on adherence to patients discharged from the emergency department
    Brian Suffoletto
    Department of Emergency Medicine, University of Pittsburgh, Pittsburgh, PA, USA
    Acad Emerg Med 19:949-58. 2012
    ..Nonadherence to prescribed medications impairs therapeutic benefits. The authors measured the ability of an automated text messaging (short message service [SMS]) system to improve adherence to postdischarge antibiotic prescriptions...
  51. ncbi request reprint A comparison of CPR delivery with various compression-to-ventilation ratios during two-rescuer CPR
    David Hostler
    University of Pittsburgh, Department of Emergency Medicine and the Affiliated Emergency Medicine Residency, 230 McKee Place, Suite 500, Pittsburgh, PA 15213, USA
    Resuscitation 65:325-8. 2005
    ..We examined human performance of two-rescuer CPR using various C:V...
  52. ncbi request reprint Cerebral oximetry in out-of-hospital cardiac arrest: standard CPR rarely provides detectable hemoglobin-oxygen saturation to the frontal cortex
    David H Newman
    Department of Emergency Medicine, St Luke s Roosevelt Hospital, 1111 Amsterdam Avenue, New York, NY 10025, USA
    Resuscitation 63:189-94. 2004
    ..Ventilation rate does not alter the oximeter readings. It is possible that the current standard mechanical method of cardiopulmonary resuscitation provides little or no cerebral oxygenation during OOHCA...
  53. ncbi request reprint Delayed hypothermia preferentially increases expression of brain-derived neurotrophic factor exon III in rat hippocampus after asphyxial cardiac arrest
    Peter S Vosler
    Department of Emergency Medicine, University of Pittsburgh, 230 McKee Place, Suite 400, Pittsburgh, PA 15213, USA
    Brain Res Mol Brain Res 135:21-9. 2005
    ..These data suggest that hypothermia after cardiac arrest produces exon-specific changes in BDNF transcription...
  54. ncbi request reprint Prevalence of troponin-T elevation during out-of-hospital cardiac arrest
    Christopher S Lai
    Department of Emergency Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Am J Cardiol 93:754-6. 2004
    ..04 to 1.17). Elevated troponin levels did not reliably predict short-term outcome. Because troponin increases hours after the onset of ischemia, these data reveal that about 40% of OOHCA cases can undergo intervention before collapse...
  55. ncbi request reprint Comparison of the effects of hypothermia at 33 degrees C or 35 degrees C after cardiac arrest in rats
    Eric S Logue
    Department of Emergency Medicine, Safar Center for Resuscitation Research, University of Pittsburgh, Pittsburgh, PA, USA
    Acad Emerg Med 14:293-300. 2007
    ..Using a rat model, the authors tested the hypothesis that cooling to 35 degrees C between hours 1 and 24 after resuscitation would improve neurologic outcome as much as cooling to 33 degrees C...
  56. ncbi request reprint Hypothermic reperfusion after cardiac arrest augments brain-derived neurotrophic factor activation
    Brian J D'Cruz
    Department of Emergency Medicine, University of Pittsburgh, Pennsylvania 15213, USA
    J Cereb Blood Flow Metab 22:843-51. 2002
    ..Increased activation of BDNF signaling is a possible mechanism by which mild hypothermia is able to reduce the neuronal damage typically occurring after cardiac arrest...
  57. ncbi request reprint Regional changes in glial cell line-derived neurotrophic factor after cardiac arrest and hypothermia in rats
    Katherine M Schmidt
    Department of Emergency Medicine, University of Pittsburgh, 230 McKee Place, Suite 400, Pittsburgh, PA 15213, USA
    Neurosci Lett 368:135-9. 2004
    ..These results suggest that temperature after resuscitation produces regionally specific changes of GNDF levels in brain...
  58. ncbi request reprint Factors contributing to emergency department care within 30 days of hospital discharge and potential ways to prevent it: differences in perspectives of patients, caregivers, and emergency physicians
    Brian Suffoletto
    Department of Emergency Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania
    J Hosp Med 9:315-9. 2014
    ..Identifying needs in patients who utilize the emergency department (ED) soon after being discharged from inpatient care is essential for planning appropriate care-transition interventions...
  59. doi request reprint Emergency physician recognition of delirium
    Brian Suffoletto
    Department of Emergency Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Postgrad Med J 89:621-5. 2013
    ....
  60. doi request reprint Text-message-based drinking assessments and brief interventions for young adults discharged from the emergency department
    Brian Suffoletto
    Department of Emergency Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    Alcohol Clin Exp Res 36:552-60. 2012
    ..The feasibility of screening young adults in the ED, recruiting them for a TM-based interventional trial, collecting weekly drinking data through TM, and the variance in drinking outcomes remains unknown...
  61. pmc Work of CPR during two different compression to ventilation ratios with real-time feedback
    Amy E Betz
    Department of Emergency Medicine, University of Pittsburgh, Pittsburgh, PA 15213, United States
    Resuscitation 79:278-82. 2008
    ..The effect of the additional exertion required to deliver more chest compressions may present a considerable physical burden on the provider...
  62. pmc Coronary angiography predicts improved outcome following cardiac arrest: propensity-adjusted analysis
    Joshua C Reynolds
    Department of Emergency Medicine, University of Maryland, Baltimore, Maryland, USA
    J Intensive Care Med 24:179-86. 2009
    ..Determine if clinical parameters of resuscitated patients predict coronary angiography (CATH) performance and if receiving CATH after cardiac arrest is associated with outcome...
  63. pmc The Resuscitation Outcomes Consortium Epistry-Trauma: design, development, and implementation of a North American epidemiologic prehospital trauma registry
    Craig D Newgard
    Center for Policy and Research in Emergency Medicine, Department of Emergency Medicine, Oregon Health and Science University, Portland, OR 97239 3098, United States
    Resuscitation 78:170-8. 2008
    ..This data registry samples patients from 264 EMS agencies transporting to 287 acute care hospitals in both the United States and Canada...
  64. pmc Regional variation in out-of-hospital cardiac arrest incidence and outcome
    Graham Nichol
    Department of Biostatistics, University of Washington Clinical Trial Center, Seattle, WA, USA
    JAMA 300:1423-31. 2008
    ..The health and policy implications of regional variation in incidence and outcome of out-of-hospital cardiac arrest remain to be determined...
  65. ncbi request reprint Winning the cold war: inroads into implementation of mild hypothermia after cardiac arrest in adults from the European Resuscitation Council Hypothermia After Cardiac Arrest Registry Study Group
    Ericka L Fink
    Crit Care Med 35:1199-202. 2007
  66. ncbi request reprint Overcoming ACLS dogma: how quickly should we change?
    James J Menegazzi
    Prehosp Emerg Care 7:410-3. 2003
    ..At the end of the year 2000 there was insufficient evidence to recommend any other approach than shock as soon as possible and perform CPR at all other times...
  67. ncbi request reprint Adenosine A1 receptor antagonism hastens the decay in ventricular fibrillation waveform morphology during porcine cardiac arrest
    Timothy J Mader
    The Department of Emergency Medicine, Baystate Medical Center Tufts University School of Medicine, 759 Chestnut Street, Springfield, MA 01199, United States
    Resuscitation 71:254-9. 2006
    ..The objective of this study was to determine the effect of ADO receptor antagonism, as measured by the scaling exponent (ScE), on the degeneration of VF over time during the circulatory phase of cardiac arrest...
  68. pmc Resuscitation Outcomes Consortium (ROC) PRIMED cardiac arrest trial methods part 1: rationale and methodology for the impedance threshold device (ITD) protocol
    Tom P Aufderheide
    Milwaukee, WI, USA
    Resuscitation 78:179-85. 2008
    ..Secondary aims are to compare functional status and depression at discharge and at 3 and 6 months post-discharge in survivors...
  69. doi request reprint Rationale, development and implementation of the Resuscitation Outcomes Consortium Epistry-Cardiac Arrest
    Laurie J Morrison
    Prehospital and Transport Medicine Research Program, Sunnybrook and Women s College Health Sciences Centre, 2075 Bayview Avenue, Suite C753, Toronto, Ontario, Canada M4N 3M5
    Resuscitation 78:161-9. 2008
    ..To describe the development, design and consequent scientific implications of the Resuscitation Outcomes Consortium (ROC) population-based registry; ROC Epistry-Cardiac Arrest...

Research Grants8

  1. Hypothermia and Gene Expression After Cardiac Arrest
    Clifton Callaway; Fiscal Year: 2002
    ..These pathways will be blocked and stimulated during hypothermic reperfusion, and behavioral and histological outcome for cardiac arrest will be measured. ..
  2. BRAIN ISCHEMIA AND MAP KINASE ACTIVATION
    Clifton Callaway; Fiscal Year: 2003
    ..The conduct of this project will provide extensive opportunities for collaboration with other basic scientists at the University of Pittsburgh, and promote the candidate's growth as an independent researcher. ..
  3. Hypothermia and Gene Expression After Cardiac Arrest
    Clifton Callaway; Fiscal Year: 2003
    ..These pathways will be blocked and stimulated during hypothermic reperfusion, and behavioral and histological outcome for cardiac arrest will be measured. ..
  4. Hypothermia and Gene Expression After Cardiac Arrest
    Clifton Callaway; Fiscal Year: 2004
    ..These pathways will be blocked and stimulated during hypothermic reperfusion, and behavioral and histological outcome for cardiac arrest will be measured. ..
  5. Hypothermia and Gene Expression After Cardiac Arrest
    Clifton Callaway; Fiscal Year: 2003
    ..These pathways will be blocked and stimulated during hypothermic reperfusion, and behavioral and histological outcome for cardiac arrest will be measured. ..
  6. Hypothermia and Gene Expression After Cardiac Arrest
    Clifton Callaway; Fiscal Year: 2005
    ..These pathways will be blocked and stimulated during hypothermic reperfusion, and behavioral and histological outcome for cardiac arrest will be measured. ..
  7. Pittsburgh Resuscitation Network
    Clifton Callaway; Fiscal Year: 2007
    ..A clinical research training core is also described for purposes of training a young investigator within the Consortium. ..