Research Topics
| Monica E CalkinsSummaryAffiliation: University of Pennsylvania Country: USA Publications
Research Grants
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Detail Information
Publications
Antisaccade performance is impaired in medically and psychiatrically healthy biological relatives of schizophrenia patientsMonica E Calkins
Neuropsychiatry Section, Schizophrenia Research Center, University of Pennsylvania School of Medicine, 10 Gates, 3400 Spruce Street, Philadelphia, PA 19104, USA
Schizophr Res 71:167-78. 2004....
The Consortium on the Genetics of Endophenotypes in Schizophrenia: model recruitment, assessment, and endophenotyping methods for a multisite collaborationMonica E Calkins
Neuropsychiatry Section, Department of Psychiatry, University of Pennsylvania, 10 Gates, 3400 Spruce St, Philadelphia, PA 19104, USA
Schizophr Bull 33:33-48. 2007..The purpose of this article is to provide a description of the COGS structure and methods, including participant recruitment and assessment...- Face recognition memory deficits and visual object memory performance in patients with schizophrenia and their relativesMonica E Calkins
University of Pennsylvania School of Medicine, 10 Gates, 3400 Spruce St, Philadelphia, PA 19104, USA
Am J Psychiatry 162:1963-6. 2005..Biological relatives of patients have similar deficits, suggesting genetic susceptibility. Because the impairment may reflect generalized object memory deficits, the authors evaluated both face and visual object recognition... - Abnormal auditory N100 amplitude: a heritable endophenotype in first-degree relatives of schizophrenia probandsBruce I Turetsky
Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Biol Psychiatry 64:1051-9. 2008..We report initial results from the COGS dataset of auditory N100 amplitude and gating as candidate endophenotypes... 
Inhibition of the P50 cerebral evoked response to repeated auditory stimuli: results from the Consortium on Genetics of SchizophreniaAnn Olincy
Department of Psychiatry, Veterans Affairs Denver Medical Center VISN 19 MIRECC, CO 80045, USA
Schizophr Res 119:175-82. 2010....- Initial heritability analyses of endophenotypic measures for schizophrenia: the consortium on the genetics of schizophreniaTiffany A Greenwood
Department of Psychiatry, University of California San Diego, La Jolla, USA
Arch Gen Psychiatry 64:1242-50. 2007..Exploration of the genetic architecture of specific endophenotypes may be a powerful strategy for understanding the genetic basis of schizophrenia... - Multi-site studies of acoustic startle and prepulse inhibition in humans: initial experience and methodological considerations based on studies by the Consortium on the Genetics of SchizophreniaNeal R Swerdlow
Department of Psychiatry, University of California San Diego, San Diego, California, USA
Schizophr Res 92:237-51. 2007..Genetic studies now often employ multiple, geographically dispersed test sites to accommodate the need for large and complex study samples. Here, we assessed the feasibility of using PPI in multi-site studies... - The Consortium on the Genetics of Schizophrenia: neurocognitive endophenotypesRaquel E Gur
Neuropsychiatry Section, Department of Psychiatry, University of Pennsylvania, 10 Gates, 3400 Spruce St, Philadelphia, PA 19104, USA
Schizophr Bull 33:49-68. 2007.... - Project among African-Americans to explore risks for schizophrenia (PAARTNERS): evidence for impairment and heritability of neurocognitive functioning in families of schizophrenia patientsMonica E Calkins
Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
Am J Psychiatry 167:459-72. 2010.... - Neurocognitive endophenotypes in a multiplex multigenerational family study of schizophreniaRaquel E Gur
Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia 19104, USA
Am J Psychiatry 164:813-9. 2007..The purpose of this article was to examine computerized neurocognitive measures as candidate endophenotypic markers of liability for schizophrenia in a genetically informative cohort... - Computerized neurocognitive test performance in schizophrenia: a lifespan analysisFarzin Irani
Department of Psychiatry, Neuropsychiatry Section, University of Pennsylvania, School of Medicine, Philadelphia, PA 19104, USA
Am J Geriatr Psychiatry 20:41-52. 2012..Favorable construct validity in younger schizophrenia patients has been reported, but not in older patients. New variables afforded by computerized assessments were used to clarify age-associated cognitive impairment across the lifespan... - Age group and sex differences in performance on a computerized neurocognitive battery in children age 8-21Ruben C Gur
Brain Behavior Laboratory, Department of Psychiatry, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA19104, USA
Neuropsychology 26:251-65. 2012..Such information is needed to incorporate behavioral data as neuropsychological "biomarkers" in large-scale genomic studies... - Analysis of 94 candidate genes and 12 endophenotypes for schizophrenia from the Consortium on the Genetics of SchizophreniaTiffany A Greenwood
Department of Psychiatry, University of California at San Diego, La Jolla, CA 92093 0804, USA
Am J Psychiatry 168:930-46. 2011.... - Computerized neurocognitive profile in young people with 22q11.2 deletion syndrome compared to youths with schizophrenia and at-risk for psychosisPaula C Goldenberg
Division of Human Genetics, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
Am J Med Genet B Neuropsychiatr Genet 159:87-93. 2012..Similar deficits have been described in the 22q11DS population using non-computerized measures, which require increased testing time... - A cognitive neuroscience-based computerized battery for efficient measurement of individual differences: standardization and initial construct validationRuben C Gur
Brain Behavior Laboratory, Section of Neuropsychiatry, Department of Psychiatry, Philadelphia, PA 19104 4283, United States
J Neurosci Methods 187:254-62. 2010..These results encourage the use of this battery in studies needing an efficient assessment of major neurocognitive domains such as multi-site genetic studies and clinical trials... - The other-race effect in face processing among African American and Caucasian individuals with schizophreniaAmy E Pinkham
Department of Neuropsychiatry, University of Pennsylvania, 10th Floor, Gates Pavilion, Philadelphia 19104, USA
Am J Psychiatry 165:639-45. 2008..The authors sought to measure the "other-race effect" in schizophrenia, which could account for previous findings and provide information about sensitivity to such social cues in patients... - An improved framework for confound regression and filtering for control of motion artifact in the preprocessing of resting-state functional connectivity dataTheodore D Satterthwaite
Department of Psychiatry, University of Pennsylvania, Philadelphia PA 19104, USA Electronic address
Neuroimage 64:240-56. 2013..These results demonstrate that the effect of motion on rsfc-MRI can be substantially attenuated through improved preprocessing procedures, but not completely removed... - Self-face recognition and theory of mind in patients with schizophrenia and first-degree relativesFarzin Irani
Department of Psychology, Drexel University, 3141 Chestnut Street, Philadelphia, PA 19104, USA
Schizophr Res 88:151-60. 2006.... - Eye movement dysfunction in first-degree relatives of patients with schizophrenia: a meta-analytic evaluation of candidate endophenotypesMonica E Calkins
Department of Psychiatry, University of Pennsylvania School of Medicine, Neuropsychiatry Section, Schizophrenia Research Center and Brain Behavior Laboratory, Philadelphia, PA 19104, USA
Brain Cogn 68:436-61. 2008..Future work should focus on facilitating endophenotype utility through attention to heterogeneity of EMD performance, relationships among forms of EMD, and application in molecular genetics studies... - Neurophysiological endophenotypes of schizophrenia: the viability of selected candidate measuresBruce I Turetsky
Department of Psychiatry, 10th Floor, Gates Building, University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104, USA
Schizophr Bull 33:69-94. 2007..We conclude with a discussion of the few studies thus far that have employed a multivariate approach with these candidates... - Multiple dimensions of schizotypy in first degree biological relatives of schizophrenia patientsMonica E Calkins
University of Pennsylvania School of Medicine, Neuropsychiatry Section, Schizophrenia Research Center, Pittsburgh, PA, USA
Schizophr Bull 30:317-25. 2004.... - An odor-specific threshold deficit implicates abnormal cAMP signaling in youths at clinical risk for psychosisVidyulata Kamath
Neuropsychiatry Section, Department of Psychiatry, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA
Schizophr Res 138:280-4. 2012..Odor-detection thresholds to two odorants that differ in the degree to which they activate intracellular cAMP were assessed in clinical risk and low-risk participants... - Challenges and opportunities for genomic developmental neuropsychology: examples from the Penn-Drexel collaborative batteryRuben C Gur
Neuropsychiatry Section, Department of Psychiatry, 10th Floor, Gates Building, University of Pennsylvania School of Medicine, 3400 Spruce Street, Philadelphia, PA 19104, USA
Clin Neuropsychol 25:1029-41. 2011..The study illustrates what will hopefully become a major component of the work of clinical and research neuropsychologists as invaluable participants in the dawning age of Big Science neuropsychological genomics... - Being right is its own reward: load and performance related ventral striatum activation to correct responses during a working memory task in youthTheodore D Satterthwaite
Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
Neuroimage 61:723-9. 2012..These findings provide evidence for scalable intrinsic reinforcement signals during standard cognitive tasks, and suggest a novel link between motivation and cognition during adolescent development... - A comparison of cognitive structure in schizophrenia patients and healthy controls using confirmatory factor analysisDwight Dickinson
Department of Psychiatry, University of Maryland School of Medicine, BT MIRECC, Baltimore, 21201, USA
Schizophr Res 85:20-9. 2006..Cognitive ability, as reflected in test performance, appears to be more unitary in schizophrenia than in healthy subjects. This finding may have measurement and treatment implications... - Evaluation and treatment of children and adolescents with psychotic symptomsSibel Algon
Department of Child and Adolescent Psychiatry Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
Curr Psychiatry Rep 14:101-10. 2012..For this article, emphasis is placed on the evaluation of symptoms, differential diagnosis, and consideration of potential interventions... - Smooth pursuit and antisaccade performance evidence trait stability in schizophrenia patients and their relativesMonica E Calkins
Department of Psychiatry, University of Pennsylvania School of Medicine, Pennsylvania, USA
Int J Psychophysiol 49:139-46. 2003..52) and prosaccade reaction time (r=0.43). The results are supportive of the trait-like characteristics of particular forms of EMD in schizophrenia families and of the candidacy of EMD as an endophenotypic marker of schizophrenia... - Unaffected family members and schizophrenia patients share brain structure patterns: a high-dimensional pattern classification studyYong Fan
Section of Biomedical Image Analysis, Department of Radiology, University of Pennsylvania, School of Medicine, Philadelphia, PA 19104, USA
Biol Psychiatry 63:118-24. 2008..This study investigates whether such endophenotypic patterns are found in FM via similar image analysis approaches... - Assessment of adolescents at risk for psychosisKarin Borgmann-Winter
Schizophrenia Research Center and Brain Behavior Laboratory, University of Pennsylvania School of Medicine, 10 Gates Building, 3400 Spruce Street, Philadelphia, PA 19104, USA
Curr Psychiatry Rep 8:313-21. 2006..This battery may assist in unraveling the complex presentation of prodromal symptoms during the adolescent developmental period... - Working memory functioning in schizophrenia patients and their first-degree relatives: cognitive functioning shedding light on etiologyHeather M Conklin
Department of Neuropsychology, Kennedy Krieger Institute, 1750 East Fairmount Avenue, Baltimore, MD 21231, USA
Neuropsychologia 43:930-42. 2005..This pattern of WM performance may further implicate DLPFC dysfunction in the liability for schizophrenia and has implications for future cognitive, genetic, and neurodevelopmental research... - A description of the process of recruitment for research studies investigating the genetics of psychotic illnessKimberly K Mathos
Western Psychiatric Institute and Clinic, 3811 O Hara Street, Pittsburgh, PA 15213, USA
Curr Psychiatry Rep 8:307-12. 2006..This preliminary study has broad implications as a potential model for collaboration among patient support groups, family groups, clinicians, and researchers... - Project among African-Americans to explore risks for schizophrenia (PAARTNERS): recruitment and assessment methodsMuktar H Aliyu
Department of Psychiatry, University of Alabama at Birmingham, Birmingham, AL 35294 2041, and Duke University Medical Center John Umstead Hospital, Butner, NC, United States
Schizophr Res 87:32-44. 2006..This novel integration of diagnostic, neurocognitive and genetic data will also generate valuable information for future phenotypic and genetic studies of schizophrenia... - A genome screen for quantitative trait loci influencing schizophrenia and neurocognitive phenotypesLaura Almasy
Department of Genetics, Southwest Foundation for Biomedical Research, P O Box 760549, San Antonio, TX 78249 0549, USA
Am J Psychiatry 165:1185-92. 2008..The authors conducted a multiplex, multigenerational family study using a genome-wide screen for schizophrenia and related neurocognitive phenotypes... - Verbal working memory impairments in individuals with schizophrenia and their first-degree relatives: findings from the Consortium on the Genetics of SchizophreniaWilliam P Horan
Department of Psychiatry and Biobehavioral Sciences, Geffen School of Medicine at University of California Los Angeles, Los Angeles, California 90095 6968, USA
Schizophr Res 103:218-28. 2008.... - Successful multi-site measurement of antisaccade performance deficits in schizophreniaAllen D Radant
Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, Washington, United States
Schizophr Res 89:320-9. 2007..These results confirm previous findings of antisaccade deficits in schizophrenia subjects and support the use of the antisaccade task as a potential schizophrenia endophenotype in multi-site genetic studies... - Recognition memory for faces in schizophrenia patients and their first-degree relativesHeather M Conklin
Department of Psychology, University of Minnesota, 75 East River Road, Minneapolis, MN 55455, USA
Neuropsychologia 40:2314-24. 2002..These findings may have important implications for reducing etiological heterogeneity among schizophrenia populations, identifying disorder susceptibility among their relatives and furthering understanding of disorder etiology...
Research Grants
- A Prospective Study of Endophenotypes in At-Risk Youths and Their SiblingsMonica Calkins; Fiscal Year: 2007....