Research Topics
| Monica E CalkinsSummaryAffiliation: University of Pennsylvania Country: USA Publications
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Detail Information
Publications
Sex differences in familiality effects on neurocognitive performance in schizophreniaMonica E Calkins
Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania Electronic address
Biol Psychiatry 73:976-84. 2013..In view of these findings, the current investigation tested the hypothesis that neurocognitive performance of schizophrenia probands can predict the neurocognitive performance of their unaffected family members...- Project among African-Americans to explore risks for schizophrenia (PAARTNERS): evidence for impairment and heritability of neurocognitive functioning in families of schizophrenia patientsMonica E Calkins
Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
Am J Psychiatry 167:459-72. 2010.... - Eye movement dysfunction in first-degree relatives of patients with schizophrenia: a meta-analytic evaluation of candidate endophenotypesMonica E Calkins
Department of Psychiatry, University of Pennsylvania School of Medicine, Neuropsychiatry Section, Schizophrenia Research Center and Brain Behavior Laboratory, Philadelphia, PA 19104, USA
Brain Cogn 68:436-61. 2008..Future work should focus on facilitating endophenotype utility through attention to heterogeneity of EMD performance, relationships among forms of EMD, and application in molecular genetics studies... 
Abnormal auditory N100 amplitude: a heritable endophenotype in first-degree relatives of schizophrenia probandsBruce I Turetsky
Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Biol Psychiatry 64:1051-9. 2008..We report initial results from the COGS dataset of auditory N100 amplitude and gating as candidate endophenotypes...- Inhibition of the P50 cerebral evoked response to repeated auditory stimuli: results from the Consortium on Genetics of SchizophreniaAnn Olincy
Department of Psychiatry, Veterans Affairs Denver Medical Center VISN 19 MIRECC, CO 80045, USA
Schizophr Res 119:175-82. 2010.... 
Initial heritability analyses of endophenotypic measures for schizophrenia: the consortium on the genetics of schizophreniaTiffany A Greenwood
Department of Psychiatry, University of California San Diego, La Jolla, USA
Arch Gen Psychiatry 64:1242-50. 2007..Exploration of the genetic architecture of specific endophenotypes may be a powerful strategy for understanding the genetic basis of schizophrenia...- The Consortium on the Genetics of Schizophrenia: neurocognitive endophenotypesRaquel E Gur
Neuropsychiatry Section, Department of Psychiatry, University of Pennsylvania, 10 Gates, 3400 Spruce St, Philadelphia, PA 19104, USA
Schizophr Bull 33:49-68. 2007.... - Multi-site studies of acoustic startle and prepulse inhibition in humans: initial experience and methodological considerations based on studies by the Consortium on the Genetics of SchizophreniaNeal R Swerdlow
Department of Psychiatry, University of California San Diego, San Diego, California, USA
Schizophr Res 92:237-51. 2007..Genetic studies now often employ multiple, geographically dispersed test sites to accommodate the need for large and complex study samples. Here, we assessed the feasibility of using PPI in multi-site studies... - The other-race effect in face processing among African American and Caucasian individuals with schizophreniaAmy E Pinkham
Department of Neuropsychiatry, University of Pennsylvania, 10th Floor, Gates Pavilion, Philadelphia 19104, USA
Am J Psychiatry 165:639-45. 2008..The authors sought to measure the "other-race effect" in schizophrenia, which could account for previous findings and provide information about sensitivity to such social cues in patients... - Neurocognitive endophenotypes in a multiplex multigenerational family study of schizophreniaRaquel E Gur
Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia 19104, USA
Am J Psychiatry 164:813-9. 2007..The purpose of this article was to examine computerized neurocognitive measures as candidate endophenotypic markers of liability for schizophrenia in a genetically informative cohort... - The Consortium on the Genetics of Endophenotypes in Schizophrenia: model recruitment, assessment, and endophenotyping methods for a multisite collaborationMonica E Calkins
Neuropsychiatry Section, Department of Psychiatry, University of Pennsylvania, 10 Gates, 3400 Spruce St, Philadelphia, PA 19104, USA
Schizophr Bull 33:33-48. 2007..The purpose of this article is to provide a description of the COGS structure and methods, including participant recruitment and assessment... - Age group and sex differences in performance on a computerized neurocognitive battery in children age 8-21Ruben C Gur
Brain Behavior Laboratory, Department of Psychiatry, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA19104, USA
Neuropsychology 26:251-65. 2012..Such information is needed to incorporate behavioral data as neuropsychological "biomarkers" in large-scale genomic studies... - Computerized neurocognitive test performance in schizophrenia: a lifespan analysisFarzin Irani
Department of Psychiatry, Neuropsychiatry Section, University of Pennsylvania, School of Medicine, Philadelphia, PA 19104, USA
Am J Geriatr Psychiatry 20:41-52. 2012..Favorable construct validity in younger schizophrenia patients has been reported, but not in older patients. New variables afforded by computerized assessments were used to clarify age-associated cognitive impairment across the lifespan... - Analysis of 94 candidate genes and 12 endophenotypes for schizophrenia from the Consortium on the Genetics of SchizophreniaTiffany A Greenwood
Department of Psychiatry, University of California at San Diego, La Jolla, CA 92093 0804, USA
Am J Psychiatry 168:930-46. 2011.... - Computerized neurocognitive profile in young people with 22q11.2 deletion syndrome compared to youths with schizophrenia and at-risk for psychosisPaula C Goldenberg
Division of Human Genetics, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
Am J Med Genet B Neuropsychiatr Genet 159:87-93. 2012..Similar deficits have been described in the 22q11DS population using non-computerized measures, which require increased testing time... - Self-face recognition and theory of mind in patients with schizophrenia and first-degree relativesFarzin Irani
Department of Psychology, Drexel University, 3141 Chestnut Street, Philadelphia, PA 19104, USA
Schizophr Res 88:151-60. 2006.... - Antisaccade performance is impaired in medically and psychiatrically healthy biological relatives of schizophrenia patientsMonica E Calkins
Neuropsychiatry Section, Schizophrenia Research Center, University of Pennsylvania School of Medicine, 10 Gates, 3400 Spruce Street, Philadelphia, PA 19104, USA
Schizophr Res 71:167-78. 2004.... - A cognitive neuroscience-based computerized battery for efficient measurement of individual differences: standardization and initial construct validationRuben C Gur
Brain Behavior Laboratory, Section of Neuropsychiatry, Department of Psychiatry, Philadelphia, PA 19104 4283, United States
J Neurosci Methods 187:254-62. 2010..These results encourage the use of this battery in studies needing an efficient assessment of major neurocognitive domains such as multi-site genetic studies and clinical trials... - Neurophysiological endophenotypes of schizophrenia: the viability of selected candidate measuresBruce I Turetsky
Department of Psychiatry, 10th Floor, Gates Building, University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104, USA
Schizophr Bull 33:69-94. 2007..We conclude with a discussion of the few studies thus far that have employed a multivariate approach with these candidates... - An improved framework for confound regression and filtering for control of motion artifact in the preprocessing of resting-state functional connectivity dataTheodore D Satterthwaite
Department of Psychiatry, University of Pennsylvania, Philadelphia PA 19104, USA
Neuroimage 64:240-56. 2013..These results demonstrate that the effect of motion on rsfc-MRI can be substantially attenuated through improved preprocessing procedures, but not completely removed... - A comparison of cognitive structure in schizophrenia patients and healthy controls using confirmatory factor analysisDwight Dickinson
Department of Psychiatry, University of Maryland School of Medicine, BT MIRECC, Baltimore, 21201, USA
Schizophr Res 85:20-9. 2006..Cognitive ability, as reflected in test performance, appears to be more unitary in schizophrenia than in healthy subjects. This finding may have measurement and treatment implications... - An odor-specific threshold deficit implicates abnormal cAMP signaling in youths at clinical risk for psychosisVidyulata Kamath
Neuropsychiatry Section, Department of Psychiatry, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA
Schizophr Res 138:280-4. 2012..Odor-detection thresholds to two odorants that differ in the degree to which they activate intracellular cAMP were assessed in clinical risk and low-risk participants... - Challenges and opportunities for genomic developmental neuropsychology: examples from the Penn-Drexel collaborative batteryRuben C Gur
Neuropsychiatry Section, Department of Psychiatry, 10th Floor, Gates Building, University of Pennsylvania School of Medicine, 3400 Spruce Street, Philadelphia, PA 19104, USA
Clin Neuropsychol 25:1029-41. 2011..The study illustrates what will hopefully become a major component of the work of clinical and research neuropsychologists as invaluable participants in the dawning age of Big Science neuropsychological genomics... - Being right is its own reward: load and performance related ventral striatum activation to correct responses during a working memory task in youthTheodore D Satterthwaite
Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
Neuroimage 61:723-9. 2012..These findings provide evidence for scalable intrinsic reinforcement signals during standard cognitive tasks, and suggest a novel link between motivation and cognition during adolescent development... - Multiple dimensions of schizotypy in first degree biological relatives of schizophrenia patientsMonica E Calkins
University of Pennsylvania School of Medicine, Neuropsychiatry Section, Schizophrenia Research Center, Pittsburgh, PA, USA
Schizophr Bull 30:317-25. 2004.... - Smooth pursuit and antisaccade performance evidence trait stability in schizophrenia patients and their relativesMonica E Calkins
Department of Psychiatry, University of Pennsylvania School of Medicine, Pennsylvania, USA
Int J Psychophysiol 49:139-46. 2003..52) and prosaccade reaction time (r=0.43). The results are supportive of the trait-like characteristics of particular forms of EMD in schizophrenia families and of the candidacy of EMD as an endophenotypic marker of schizophrenia... - Evaluation and treatment of children and adolescents with psychotic symptomsSibel Algon
Department of Child and Adolescent Psychiatry Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
Curr Psychiatry Rep 14:101-10. 2012..For this article, emphasis is placed on the evaluation of symptoms, differential diagnosis, and consideration of potential interventions... - Unaffected family members and schizophrenia patients share brain structure patterns: a high-dimensional pattern classification studyYong Fan
Section of Biomedical Image Analysis, Department of Radiology, University of Pennsylvania, School of Medicine, Philadelphia, PA 19104, USA
Biol Psychiatry 63:118-24. 2008..This study investigates whether such endophenotypic patterns are found in FM via similar image analysis approaches... - Face recognition memory deficits and visual object memory performance in patients with schizophrenia and their relativesMonica E Calkins
University of Pennsylvania School of Medicine, 10 Gates, 3400 Spruce St, Philadelphia, PA 19104, USA
Am J Psychiatry 162:1963-6. 2005..Biological relatives of patients have similar deficits, suggesting genetic susceptibility. Because the impairment may reflect generalized object memory deficits, the authors evaluated both face and visual object recognition... - Evaluation of HLA polymorphisms in relation to schizophrenia risk and infectious exposureMikhil Bamne
Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, Pittsburgh, PA, USA
Schizophr Bull 38:1149-54. 2012..3-22.1, the human leukocyte antigen (HLA) region, as common risk factors for schizophrenia (SZ). Other studies implicate viral and protozoan exposure. Our study tests chromosome 6p SNPs for effects on SZ risk with and without exposure... - Assessment of adolescents at risk for psychosisKarin Borgmann-Winter
Schizophrenia Research Center and Brain Behavior Laboratory, University of Pennsylvania School of Medicine, 10 Gates Building, 3400 Spruce Street, Philadelphia, PA 19104, USA
Curr Psychiatry Rep 8:313-21. 2006..This battery may assist in unraveling the complex presentation of prodromal symptoms during the adolescent developmental period...