William Calhoun

Summary

Affiliation: University of Texas Medical Branch
Country: USA

Publications

  1. pmc Comparison of physician-, biomarker-, and symptom-based strategies for adjustment of inhaled corticosteroid therapy in adults with asthma: the BASALT randomized controlled trial
    William J Calhoun
    Department of Internal Medicine, University of Texas Medical Branch, Galveston, TX 77555, USA
    JAMA 308:987-97. 2012
  2. pmc Molecular phenotyping of severe asthma using pattern recognition of bronchoalveolar lavage-derived cytokines
    Allan R Brasier
    Department of Internal Medicine, University of Texas Medical Branch, Galveston, TX 77555 1060, USA
    J Allergy Clin Immunol 121:30-37.e6. 2008
  3. ncbi request reprint Lung function in adults with stable but severe asthma: air trapping and incomplete reversal of obstruction with bronchodilation
    Ronald L Sorkness
    Univ of Wisconsin, 777 Highland Ave, Madison, WI 53705, USA
    J Appl Physiol 104:394-403. 2008
  4. pmc Characterization of the severe asthma phenotype by the National Heart, Lung, and Blood Institute's Severe Asthma Research Program
    Wendy C Moore
    Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    J Allergy Clin Immunol 119:405-13. 2007
  5. pmc IL4R alpha mutations are associated with asthma exacerbations and mast cell/IgE expression
    Sally E Wenzel
    University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
    Am J Respir Crit Care Med 175:570-6. 2007
  6. ncbi request reprint Alterations in nitric oxide and cytokine production with airway inflammation in the absence of IL-10
    Bill T Ameredes
    Asthma, Allergy, and Airway Research Center, Division of Pulmonary, Allergy, and Critical Care Medicine, University of Pittsburgh School of Medicine, 3459 Fifth Avenue, Pittsburgh, PA 15261, USA
    J Immunol 175:1206-13. 2005
  7. pmc Alterations of the arginine metabolome in asthma
    Abigail Lara
    Department of Pathobiology, The Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Am J Respir Crit Care Med 178:673-81. 2008
  8. pmc Airway lipoxin A4 generation and lipoxin A4 receptor expression are decreased in severe asthma
    Anna Planagumà
    Pulmonary and Critical Care Medicine Division, Department of Internal Medicine, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
    Am J Respir Crit Care Med 178:574-82. 2008
  9. pmc Non-invasive measurements of exhaled NO and CO associated with methacholine responses in mice
    Jigme M Sethi
    Division of Allergy, Pulmonary, Immunology, Critical Care and Sleep Division, Department of Internal Medicine, University of Texas Medical Branch, Galveston TX 77755 1083, USA
    Respir Res 9:45. 2008
  10. ncbi request reprint Asthma variability in patients previously treated with beta2-agonists alone
    William J Calhoun
    Division of Pulmonary Allergy, and Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA
    J Allergy Clin Immunol 112:1088-94. 2003

Research Grants

  1. The Role of IL-10 in Regulation of Allergic Inflammation
    BILL AMEREDES; Fiscal Year: 2005
  2. ASTHMA CLINICAL RESEARCH NETWORK
    William Calhoun; Fiscal Year: 2007
  3. Mechanisms of Steroid Resistance in Severe Asthma
    William Calhoun; Fiscal Year: 2005

Collaborators

Detail Information

Publications18

  1. pmc Comparison of physician-, biomarker-, and symptom-based strategies for adjustment of inhaled corticosteroid therapy in adults with asthma: the BASALT randomized controlled trial
    William J Calhoun
    Department of Internal Medicine, University of Texas Medical Branch, Galveston, TX 77555, USA
    JAMA 308:987-97. 2012
    ..Approaches include adjustment at outpatient visits guided by physician assessment of asthma control (symptoms, rescue therapy, pulmonary function), based on exhaled nitric oxide, or on a day-to-day basis guided by symptoms...
  2. pmc Molecular phenotyping of severe asthma using pattern recognition of bronchoalveolar lavage-derived cytokines
    Allan R Brasier
    Department of Internal Medicine, University of Texas Medical Branch, Galveston, TX 77555 1060, USA
    J Allergy Clin Immunol 121:30-37.e6. 2008
    ..Asthma is a heterogeneous clinical disorder. Methods for objective identification of disease subtypes will focus on clinical interventions and help identify causative pathways. Few studies have explored phenotypes at a molecular level...
  3. ncbi request reprint Lung function in adults with stable but severe asthma: air trapping and incomplete reversal of obstruction with bronchodilation
    Ronald L Sorkness
    Univ of Wisconsin, 777 Highland Ave, Madison, WI 53705, USA
    J Appl Physiol 104:394-403. 2008
    ..We conclude that air trapping is a characteristic feature of the severe asthma population, suggesting that there is a pathological process associated with severe asthma that makes airways more vulnerable to this component...
  4. pmc Characterization of the severe asthma phenotype by the National Heart, Lung, and Blood Institute's Severe Asthma Research Program
    Wendy C Moore
    Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    J Allergy Clin Immunol 119:405-13. 2007
    ..Severe asthma causes the majority of asthma morbidity. Understanding mechanisms that contribute to the development of severe disease is important...
  5. pmc IL4R alpha mutations are associated with asthma exacerbations and mast cell/IgE expression
    Sally E Wenzel
    University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
    Am J Respir Crit Care Med 175:570-6. 2007
    ..However, an effect on exacerbations and tissue inflammation has not been shown...
  6. ncbi request reprint Alterations in nitric oxide and cytokine production with airway inflammation in the absence of IL-10
    Bill T Ameredes
    Asthma, Allergy, and Airway Research Center, Division of Pulmonary, Allergy, and Critical Care Medicine, University of Pittsburgh School of Medicine, 3459 Fifth Avenue, Pittsburgh, PA 15261, USA
    J Immunol 175:1206-13. 2005
    ..Inhibition of IL-4 production, with inhibition of NOS in the absence of IL-10, demonstrated the importance of a NO and IL-4 feedback mechanism regulating this interaction...
  7. pmc Alterations of the arginine metabolome in asthma
    Abigail Lara
    Department of Pathobiology, The Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Am J Respir Crit Care Med 178:673-81. 2008
    ..As the sole nitrogen donor in nitric oxide (NO) synthesis and key intermediate in the urea cycle, arginine and its metabolic pathways are integrally linked to cellular respiration, metabolism, and inflammation...
  8. pmc Airway lipoxin A4 generation and lipoxin A4 receptor expression are decreased in severe asthma
    Anna Planagumà
    Pulmonary and Critical Care Medicine Division, Department of Internal Medicine, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
    Am J Respir Crit Care Med 178:574-82. 2008
    ..Airway inflammation is common in severe asthma despite antiinflammatory therapy with corticosteroids. Lipoxin A(4) (LXA(4)) is an arachidonic acid-derived mediator that serves as an agonist for resolution of inflammation...
  9. pmc Non-invasive measurements of exhaled NO and CO associated with methacholine responses in mice
    Jigme M Sethi
    Division of Allergy, Pulmonary, Immunology, Critical Care and Sleep Division, Department of Internal Medicine, University of Texas Medical Branch, Galveston TX 77755 1083, USA
    Respir Res 9:45. 2008
    ..Therefore, obtaining their measures simply, non-invasively, and repeatedly, is of interest, and was the purpose of the current study...
  10. ncbi request reprint Asthma variability in patients previously treated with beta2-agonists alone
    William J Calhoun
    Division of Pulmonary Allergy, and Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA
    J Allergy Clin Immunol 112:1088-94. 2003
    ..Although it is widely believed that patients might not remain consistently in any given severity category over time, few studies have examined this directly...
  11. ncbi request reprint Enhanced nitric oxide production associated with airway hyporesponsiveness in the absence of IL-10
    Bill T Ameredes
    Asthma, Allergy, and Airway Research Center, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Am J Physiol Lung Cell Mol Physiol 288:L868-73. 2005
    ..These findings suggest that airway NO production can modulate airway smooth muscle contractility, resulting in airway hyporesponsiveness when IL-10 is absent...
  12. ncbi request reprint Nebulized arformoterol in patients with COPD: a 12-week, multicenter, randomized, double-blind, double-dummy, placebo- and active-controlled trial
    Rudolf A Baumgartner
    Sepracor Inc, Marlborough, Massachusetts 01752, USA
    Clin Ther 29:261-78. 2007
    ....
  13. ncbi request reprint Regarding "Differential control of T(H)1 versus T(H)2 cell responses by the combination of low-dose steroids with beta(2)-adrenergic agonists"
    Jason H C Friesen
    J Allergy Clin Immunol 115:424; author reply 425. 2005
  14. pmc Superoxide dismutase inactivation in pathophysiology of asthmatic airway remodeling and reactivity
    Suzy A A Comhair
    Department of Pathobiology, The Lerner Research Institute, Cleveland Clinic Foundation, 9500 Euclid Ave, Cleveland, OH 44195, USA
    Am J Pathol 166:663-74. 2005
    ..These findings link oxidative and nitrative stress to loss of SOD activity and downstream events that typify asthma, including apoptosis and shedding of the airway epithelium and hyperresponsiveness...
  15. ncbi request reprint (R)-albuterol for asthma: pro [a.k.a. (S)-albuterol for asthma: con]
    Bill T Ameredes
    Am J Respir Crit Care Med 174:965-9; discussion 972-4. 2006
    ..presented further refines the question as "Do we wish to continue to treat asthma with a mixture of albuterol, of which half is an agent with no known benefit--that is, (S)-albuterol--and which may exacerbate the disease?"..
  16. ncbi request reprint The role of leukotrienes in airway inflammation
    Yoshiko Ogawa
    Division of Allergy, Pulmonary, Immunology, Critical Care, and Sleep APICS, University of Texas Medical Branch, TX 77555 0561, USA
    J Allergy Clin Immunol 118:789-98; quiz 799-800. 2006
    ..Genetic polymorphisms and environmental factors, such as tobacco smoke exposure, might underlie some of the heterogeneity of response to LT blockers...
  17. ncbi request reprint Inhibition of phosphodiesterase 4 amplifies cytokine-dependent induction of arginase in macrophages
    Aaron Erdely
    Dept of Molecular Genetics and Biochemistry, W1255 Biomedical Science Tower, Univ of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    Am J Physiol Lung Cell Mol Physiol 290:L534-9. 2006
    ..Therefore, consequences of increased arginase expression should be evaluated whenever PDE inhibitors are proposed for treatment of inflammatory disorders in which IL-4 and/or TGF-beta predominate...
  18. ncbi request reprint Nocturnal asthma
    William J Calhoun
    Asthma, Allergy, and Airway Research Center, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Chest 123:399S-405S. 2003
    ..The treatment of asthma with effective controller agents can reduce nighttime symptoms, improve psychometric outcomes, and improve QOL...

Research Grants15

  1. The Role of IL-10 in Regulation of Allergic Inflammation
    BILL AMEREDES; Fiscal Year: 2005
    ..This information will provide direct evidence of the role of IL-10 in regulating allergic inflammation, and will help to ascertain the relationships between inflammation and airway hyperresponsiveness. ..
  2. ASTHMA CLINICAL RESEARCH NETWORK
    William Calhoun; Fiscal Year: 2007
    ..Pitt strongly supports collaborative, clinical network research. Data from the DART and ESTA trials can help to improve the care of patients with asthma. ..
  3. Mechanisms of Steroid Resistance in Severe Asthma
    William Calhoun; Fiscal Year: 2005
    ..abstract_text> ..