Ray A Caldwell

Summary

Affiliation: University of North Carolina
Country: USA

Publications

  1. pmc In vivo airway surface liquid Cl- analysis with solid-state electrodes
    Ray A Caldwell
    Cystic Fibrosis Pulmonary Research and Treatment Center, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    J Gen Physiol 119:3-14. 2002
  2. ncbi request reprint Serine protease activation of near-silent epithelial Na+ channels
    Ray A Caldwell
    Cystic Fibrosis Pulmonary Research and Treatment Center, CB 7248, University of North Carolina, Chapel Hill, NC 27599 7248, USA
    Am J Physiol Cell Physiol 286:C190-4. 2004
  3. ncbi request reprint Neutrophil elastase activates near-silent epithelial Na+ channels and increases airway epithelial Na+ transport
    Ray A Caldwell
    Cystic Fibrosis Pulmonary Research and Treatment Center, University of North Carolina, Chapel Hill, NC 27599 7248, USA
    Am J Physiol Lung Cell Mol Physiol 288:L813-9. 2005
  4. pmc Increased folding and channel activity of a rare cystic fibrosis mutant with CFTR modulators
    Ray A Caldwell
    Dept of Cell and Developmental Biology, Univ of North Carolina, Chapel Hill, NC 27599, USA
    Am J Physiol Lung Cell Mol Physiol 301:L346-52. 2011
  5. doi request reprint Pharmacological properties of N-(3,5-diamino-6-chloropyrazine-2-carbonyl)-N'-4-[4-(2,3-dihydroxypropoxy)phenyl]butyl-guanidine methanesulfonate (552-02), a novel epithelial sodium channel blocker with potential clinical efficacy for cystic fibrosis lung d
    Andrew J Hirsh
    Parion Sciences Inc, 2525 Meridian Pkwy, Suite 260, Durham, NC 27713, USA
    J Pharmacol Exp Ther 325:77-88. 2008

Research Grants

Detail Information

Publications5

  1. pmc In vivo airway surface liquid Cl- analysis with solid-state electrodes
    Ray A Caldwell
    Cystic Fibrosis Pulmonary Research and Treatment Center, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    J Gen Physiol 119:3-14. 2002
    ..3 +/- 7.1 mM, n = 5) and monkey (128.5 +/- 6.8 mM, n = 3). The measured [Cl-], in excess of 100 mM throughout all airway regions tested in multiple species, is consistent with the isotonic volume hypothesis to describe ASL physiology...
  2. ncbi request reprint Serine protease activation of near-silent epithelial Na+ channels
    Ray A Caldwell
    Cystic Fibrosis Pulmonary Research and Treatment Center, CB 7248, University of North Carolina, Chapel Hill, NC 27599 7248, USA
    Am J Physiol Cell Physiol 286:C190-4. 2004
    ..Modulation of ENaC Po by endogenous epithelial serine proteases is a potentially important regulator of epithelial Na+ transport, distinct from the regulation achieved by hormone-induced plasma membrane insertion of channels...
  3. ncbi request reprint Neutrophil elastase activates near-silent epithelial Na+ channels and increases airway epithelial Na+ transport
    Ray A Caldwell
    Cystic Fibrosis Pulmonary Research and Treatment Center, University of North Carolina, Chapel Hill, NC 27599 7248, USA
    Am J Physiol Lung Cell Mol Physiol 288:L813-9. 2005
    ..The hNE-induced increase of near-silent ENaC activity in CF airways could contribute to Na(+) hyperabsorption, reduced airway surface liquid height, and dehydrated mucus culminating in inefficient mucociliary clearance...
  4. pmc Increased folding and channel activity of a rare cystic fibrosis mutant with CFTR modulators
    Ray A Caldwell
    Dept of Cell and Developmental Biology, Univ of North Carolina, Chapel Hill, NC 27599, USA
    Am J Physiol Lung Cell Mol Physiol 301:L346-52. 2011
    ..These data suggest that CF patients with rare mutations that cause CFTR misfolding, such as CFTRV232D, may benefit from treatment with folding correctors and channel potentiators in development to restore CFTRΔF508 function...
  5. doi request reprint Pharmacological properties of N-(3,5-diamino-6-chloropyrazine-2-carbonyl)-N'-4-[4-(2,3-dihydroxypropoxy)phenyl]butyl-guanidine methanesulfonate (552-02), a novel epithelial sodium channel blocker with potential clinical efficacy for cystic fibrosis lung d
    Andrew J Hirsh
    Parion Sciences Inc, 2525 Meridian Pkwy, Suite 260, Durham, NC 27713, USA
    J Pharmacol Exp Ther 325:77-88. 2008
    ..In summary, the preclinical data support the clinical use of 552-02 +/- hypertonic saline for CF lung disease...

Research Grants1

  1. Serine-Protease Effects on the Epithelial Sodium Channel
    Ray Caldwell; Fiscal Year: 2006
    ..Collectively, these components will be vital for him to emerge as an independent investigator ..