J H Caldwell

Summary

Affiliation: University of Colorado Health Sciences Center
Country: USA

Publications

  1. ncbi Sodium channel Na(v)1.6 is localized at nodes of ranvier, dendrites, and synapses
    J H Caldwell
    Department of Cellular and Structural Biology, University of Colorado Health Sciences Center, 4200 East Ninth Avenue, Denver, CO 80262, USA
    Proc Natl Acad Sci U S A 97:5616-20. 2000
  2. ncbi Increases in intracellular calcium triggered by channelrhodopsin-2 potentiate the response of metabotropic glutamate receptor mGluR7
    John H Caldwell
    Department of Neurochemistry, Max Planck Institute for Brain Research, D 60528 Frankfurt am Main, Germany
    J Biol Chem 283:24300-7. 2008
  3. ncbi A novel, abundant sodium channel expressed in neurons and glia
    K L Schaller
    Department of Cellular and Structural Biology, University of Colorado Health Sciences Center, Denver 80262, USA
    J Neurosci 15:3231-42. 1995
  4. ncbi Structural determinants of calmodulin binding to the intracellular C-terminal domain of the metabotropic glutamate receptor 7A
    Astrid Scheschonka
    Department of Neurochemistry, Max Planck Institute for Brain Research, 60528 Frankfurt, Germany
    J Biol Chem 283:5577-88. 2008
  5. ncbi Cloning, immunolocalization, and functional expression of a GABA transporter from the retina of the skate
    Andrea D Birnbaum
    Department of Biological Sciences, University of Illinois at Chicago, Chicago, IL 60607, USA
    Vis Neurosci 22:211-23. 2005
  6. ncbi Functional specialization of the axon initial segment by isoform-specific sodium channel targeting
    Tatiana Boiko
    Department of Neurobiology and Behavior, State University of New York, Stony Brook, New York 11794, USA
    J Neurosci 23:2306-13. 2003
  7. ncbi A large-conductance anion channel of the Golgi complex
    Roger J Thompson
    Department of Cellular and Structural Biology, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Biophys J 83:278-89. 2002
  8. ncbi Pores galore for the Golgi
    John H Caldwell
    John H. Caldwell and Kathryn E. Howell are in the Department of Cell and Developmental Biology, University of Colorado Denver, School of Medicine, Aurora, CO 80045, USA
    Nat Cell Biol 10:1125-6. 2008
  9. ncbi Modulation of skeletal and cardiac voltage-gated sodium channels by calmodulin
    Katharine A Young
    Campus Box 8315, Dept of Cell Devel Biology and the Neuroscience Program, UCHSC, PO Box 6511, Aurora, CO 80045, USA
    J Physiol 565:349-70. 2005
  10. ncbi Expression and distribution of voltage-gated sodium channels in the cerebellum
    Kristin L Schaller
    Department of Cellular and Structural Biology, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Cerebellum 2:2-9. 2003

Research Grants

  1. ION CHANNELS IN MUSCLE
    John Caldwell; Fiscal Year: 1993
  2. EDNOGENOUS ION CHANELS OF THE GOLGI COMPLEX
    John Caldwell; Fiscal Year: 2002
  3. ION CHANNELS IN THE NERVOUS SYSTEM
    John Caldwell; Fiscal Year: 2003

Collaborators

Detail Information

Publications12

  1. ncbi Sodium channel Na(v)1.6 is localized at nodes of ranvier, dendrites, and synapses
    J H Caldwell
    Department of Cellular and Structural Biology, University of Colorado Health Sciences Center, 4200 East Ninth Avenue, Denver, CO 80262, USA
    Proc Natl Acad Sci U S A 97:5616-20. 2000
    ..Thus, a single sodium channel isoform is targeted to different neuronal domains and can influence both axonal conduction and synaptic responses...
  2. ncbi Increases in intracellular calcium triggered by channelrhodopsin-2 potentiate the response of metabotropic glutamate receptor mGluR7
    John H Caldwell
    Department of Neurochemistry, Max Planck Institute for Brain Research, D 60528 Frankfurt am Main, Germany
    J Biol Chem 283:24300-7. 2008
    ....
  3. ncbi A novel, abundant sodium channel expressed in neurons and glia
    K L Schaller
    Department of Cellular and Structural Biology, University of Colorado Health Sciences Center, Denver 80262, USA
    J Neurosci 15:3231-42. 1995
    ..RT-PCR and/or in situ hybridization showed that astrocytes and Schwann cells express NaCh6. Thus, this sodium channel is broadly distributed throughout the nervous system and is shown to be expressed in both neurons and glial cells...
  4. ncbi Structural determinants of calmodulin binding to the intracellular C-terminal domain of the metabotropic glutamate receptor 7A
    Astrid Scheschonka
    Department of Neurochemistry, Max Planck Institute for Brain Research, 60528 Frankfurt, Germany
    J Biol Chem 283:5577-88. 2008
    ..Our data provide insight into how Ca2+/CaM regulates group III mGluR signaling via competition with intracellular proteins for receptor-binding sites...
  5. ncbi Cloning, immunolocalization, and functional expression of a GABA transporter from the retina of the skate
    Andrea D Birnbaum
    Department of Biological Sciences, University of Illinois at Chicago, Chicago, IL 60607, USA
    Vis Neurosci 22:211-23. 2005
    ..Antibodies for both transporters showed labeling in the outer and inner plexiform layers, and staining extended from the outer to inner limiting membranes...
  6. ncbi Functional specialization of the axon initial segment by isoform-specific sodium channel targeting
    Tatiana Boiko
    Department of Neurobiology and Behavior, State University of New York, Stony Brook, New York 11794, USA
    J Neurosci 23:2306-13. 2003
    ..Expression at nodes but not initial segments exhibits an additional requirement for intact myelination. Because of their high density at the initial segment, Na(v)1.6 channels may be crucial in determining neuronal firing properties...
  7. ncbi A large-conductance anion channel of the Golgi complex
    Roger J Thompson
    Department of Cellular and Structural Biology, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Biophys J 83:278-89. 2002
    ..GOALC-2 may function as a source of counter anions for the H(+)-ATPase and may be involved in regulating charge balance and membrane potential of the Golgi complex...
  8. ncbi Pores galore for the Golgi
    John H Caldwell
    John H. Caldwell and Kathryn E. Howell are in the Department of Cell and Developmental Biology, University of Colorado Denver, School of Medicine, Aurora, CO 80045, USA
    Nat Cell Biol 10:1125-6. 2008
  9. ncbi Modulation of skeletal and cardiac voltage-gated sodium channels by calmodulin
    Katharine A Young
    Campus Box 8315, Dept of Cell Devel Biology and the Neuroscience Program, UCHSC, PO Box 6511, Aurora, CO 80045, USA
    J Physiol 565:349-70. 2005
    ..These results in heterologous cells suggest that Ca2+ released during muscle contraction rapidly modulates NaCh availability via CaM...
  10. ncbi Expression and distribution of voltage-gated sodium channels in the cerebellum
    Kristin L Schaller
    Department of Cellular and Structural Biology, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Cerebellum 2:2-9. 2003
    ..Electrophysiological studies suggest that Nav1.6 is responsible for spontaneous firing and bursting features in Purkinje cells, but the specialized functions of the other subunits in the cerebellum remain unknown...
  11. ncbi Anion channels transport ATP into the Golgi lumen
    Roger J Thompson
    Dept. of Cell and Developmental Biology, Univ. of Colorado Health Sciences Center, Aurora, CO 80045, USA
    Am J Physiol Cell Physiol 290:C499-514. 2006
    ..We conclude that the GOLACs play dual roles in the Golgi complex, providing pathways for Cl(-) and ATP influx into the Golgi lumen...
  12. ncbi Tetrodotoxin-resistant voltage-gated sodium channels Na(v)1.8 and Na(v)1.9 are expressed in the retina
    Brendan J O'Brien
    Department of Optometry and Vision Science, University of Auckland, Private Bag 92019, Auckland, New Zealand
    J Comp Neurol 508:940-51. 2008
    ....

Research Grants16

  1. ION CHANNELS IN MUSCLE
    John Caldwell; Fiscal Year: 1993
    ..These studies will also be done another multinucleated cell, the eel electrocyte, which also segregates membrane proteins (sodium channels, acetylcholine receptors, and sodium-potassium pumps)...
  2. EDNOGENOUS ION CHANELS OF THE GOLGI COMPLEX
    John Caldwell; Fiscal Year: 2002
    ..From a clinical viewpoint, there are an increasing number of diseases classified as ion channelopathies. It is likely that some human diseases will be due to mutations of endogenous Golgi channels. ..
  3. ION CHANNELS IN THE NERVOUS SYSTEM
    John Caldwell; Fiscal Year: 2003
    ..It is expected that mutations in brain sodium channels and in the proteins that bind to NaChs will produce CNS disorders in humans, and the proposed studies will contribute to our understanding of these disorders. ..