Guy A Caldwell

Summary

Affiliation: University of Alabama
Country: USA

Publications

  1. ncbi request reprint Suppression of polyglutamine-induced protein aggregation in Caenorhabditis elegans by torsin proteins
    Guy A Caldwell
    The University of Alabama, Department of Biological Sciences, Tuscaloosa, AL 35487, USA
    Hum Mol Genet 12:307-19. 2003
  2. pmc Traversing a wormhole to combat Parkinson's disease
    Guy A Caldwell
    Department of Biological Sciences, The University of Alabama, Tuscaloosa, AL 35487, USA
    Dis Model Mech 1:32-6. 2008
  3. ncbi request reprint Acetaminophen attenuates dopamine neuron degeneration in animal models of Parkinson's disease
    Cody J Locke
    Department of Biological Sciences, The University of Alabama, Tuscaloosa, AL 35487, USA
    Neurosci Lett 439:129-33. 2008
  4. pmc The early-onset torsion dystonia-associated protein, torsinA, is a homeostatic regulator of endoplasmic reticulum stress response
    Pan Chen
    Department of Biological Sciences, The University of Alabama, Tuscaloosa, AL 35487, USA
    Hum Mol Genet 19:3502-15. 2010
  5. ncbi request reprint Genetic interactions among cortical malformation genes that influence susceptibility to convulsions in C. elegans
    Cody J Locke
    Department of Biological Sciences, The University of Alabama, Box 870344, Tuscaloosa, AL 35487 0344, USA
    Brain Res 1120:23-34. 2006
  6. ncbi request reprint Torsin-mediated protection from cellular stress in the dopaminergic neurons of Caenorhabditis elegans
    Songsong Cao
    Department of Biological Sciences, The University of Alabama, Tuscaloosa, Alabama 35487, USA
    J Neurosci 25:3801-12. 2005
  7. doi request reprint Caenorhabditis elegans as a model system for identifying effectors of α-synuclein misfolding and dopaminergic cell death associated with Parkinson's disease
    Adam J Harrington
    Department of Biological Sciences, The University of Alabama, Tuscaloosa, AL 35487, USA
    Methods 53:220-5. 2011
  8. pmc Hypothesis-based RNAi screening identifies neuroprotective genes in a Parkinson's disease model
    Shusei Hamamichi
    Department of Biological Sciences, University of Alabama, Tuscaloosa, AL 35487, USA
    Proc Natl Acad Sci U S A 105:728-33. 2008
  9. pmc Valproic acid ameliorates C. elegans dopaminergic neurodegeneration with implications for ERK-MAPK signaling
    Bwarenaba B Kautu
    Department of Biological Sciences, The University of Alabama, Tuscaloosa, AL 35487, United States
    Neurosci Lett 541:116-9. 2013
  10. doi request reprint Functional analysis of VPS41-mediated neuroprotection in Caenorhabditis elegans and mammalian models of Parkinson's disease
    Adam J Harrington
    Department of Biological Sciences, The University of Alabama, Tuscaloosa, Alabama 35487, USA
    J Neurosci 32:2142-53. 2012

Collaborators

  • Kim A Caldwell
  • Perry F Churchill
  • XANDRA OWENS BREAKEFIELD
  • Dimitri Krainc
  • Jue Chen
  • Yuqing Li
  • Charles Keller
  • Jun Lu
  • Lynn Boyd
  • Talene A Yacoubian
  • Rebecca A Howard
  • David G Standaert
  • Fumiaki Yokoi
  • Erich M Schwarz
  • L A Berkowitz
  • M Chalfie
  • C Patterson
  • Nancy Bonini
  • DENNIS WILLIAM DICKSON
  • Adam J Harrington
  • Songsong Cao
  • Shusei Hamamichi
  • Adam L Knight
  • Pan Chen
  • Cody J Locke
  • Alexander J Burdette
  • Shelli N Williams
  • Aaron D Gitler
  • Xiaohui Yan
  • Michelle L Thompson
  • Akeem R Borom
  • Bwarenaba B Kautu
  • Paige M Dexter
  • Michelle L Tucci
  • Jeffrey W Hewett
  • Flavia C Nery
  • Stacey A Fox
  • Lindsay M Faircloth
  • Susan Lindquist
  • Katherine E Strathearn
  • Jean Christophe Rochet
  • Chad A Dickey
  • Antony A Cooper
  • Shifang Zhang
  • Jonathan P Aumais
  • Nathan B Roberts
  • JANIS M O'DONNELL
  • Lindsay R Roberts
  • Joseph R Mazzulli
  • J Gavin Daigle
  • Rami R Ajjuri
  • Siyuan Zhang
  • S Kyle Lee
  • Hanna Kim
  • Coralie Viollet-Djelassi
  • Mike W Zhang
  • Susan M DeLeon
  • Alejandro Carrasquilla
  • Matthew L Hicks
  • Sunny R Slone
  • J Christopher Porter
  • John C Ricketts
  • Amber Clark Buckley
  • Renee N Rivas
  • Linhui Julie Su
  • James Shorter
  • Charles Barlowe
  • J Michael McCaffery
  • Brooke J Bevis
  • Leonard Petrucelli
  • Wen Lang Lin
  • Cynthia Zehr
  • Kangning Liu
  • Michael Hutton
  • Wing C Lee
  • Kathryn J Hill
  • Bhupinder Bhullar
  • Amber M K Clark
  • Richard D Kolodner
  • Anil Cashikar
  • Joshua Labaer
  • Kexiang Xu
  • Gerald Marsischky
  • Gemma West
  • Cole M Haynes
  • Fang Liu
  • Mei Yue
  • Judith H Dunmore
  • Christopher Eckman
  • Christopher C Gelwix

Detail Information

Publications28

  1. ncbi request reprint Suppression of polyglutamine-induced protein aggregation in Caenorhabditis elegans by torsin proteins
    Guy A Caldwell
    The University of Alabama, Department of Biological Sciences, Tuscaloosa, AL 35487, USA
    Hum Mol Genet 12:307-19. 2003
    ....
  2. pmc Traversing a wormhole to combat Parkinson's disease
    Guy A Caldwell
    Department of Biological Sciences, The University of Alabama, Tuscaloosa, AL 35487, USA
    Dis Model Mech 1:32-6. 2008
    ..Moreover, with mature bioinformatic and functional genomic data readily available, the nematode is well positioned to play an increasingly important role in PD-associated discoveries...
  3. ncbi request reprint Acetaminophen attenuates dopamine neuron degeneration in animal models of Parkinson's disease
    Cody J Locke
    Department of Biological Sciences, The University of Alabama, Tuscaloosa, AL 35487, USA
    Neurosci Lett 439:129-33. 2008
    ..Taken together, these studies imply an activity for acetaminophen in the attenuation of DA neuron loss that, following essential corroborative analyses in mammalian systems, may represent a potential benefit for PD...
  4. pmc The early-onset torsion dystonia-associated protein, torsinA, is a homeostatic regulator of endoplasmic reticulum stress response
    Pan Chen
    Department of Biological Sciences, The University of Alabama, Tuscaloosa, AL 35487, USA
    Hum Mol Genet 19:3502-15. 2010
    ....
  5. ncbi request reprint Genetic interactions among cortical malformation genes that influence susceptibility to convulsions in C. elegans
    Cody J Locke
    Department of Biological Sciences, The University of Alabama, Box 870344, Tuscaloosa, AL 35487 0344, USA
    Brain Res 1120:23-34. 2006
    ..Thus, interactions among gene products with LIS-1 may mediate intrinsic thresholds of neuronal synchrony...
  6. ncbi request reprint Torsin-mediated protection from cellular stress in the dopaminergic neurons of Caenorhabditis elegans
    Songsong Cao
    Department of Biological Sciences, The University of Alabama, Tuscaloosa, Alabama 35487, USA
    J Neurosci 25:3801-12. 2005
    ..Together, these data have mechanistic implications for movement disorders, because our results demonstrate that torsin proteins have the capacity to manage sources of cellular stress within DA neurons...
  7. doi request reprint Caenorhabditis elegans as a model system for identifying effectors of α-synuclein misfolding and dopaminergic cell death associated with Parkinson's disease
    Adam J Harrington
    Department of Biological Sciences, The University of Alabama, Tuscaloosa, AL 35487, USA
    Methods 53:220-5. 2011
    ..Using these models, we describe the use of RNA interference (RNAi) and transgenic gene expression to functionally elucidate potential therapeutic gene targets that alter α-syn misfolding and DA neurotoxicity...
  8. pmc Hypothesis-based RNAi screening identifies neuroprotective genes in a Parkinson's disease model
    Shusei Hamamichi
    Department of Biological Sciences, University of Alabama, Tuscaloosa, AL 35487, USA
    Proc Natl Acad Sci U S A 105:728-33. 2008
    ..These data represent putative genetic susceptibility loci and potential therapeutic targets for PD, a movement disorder affecting approximately 2% of the population over 65 years of age...
  9. pmc Valproic acid ameliorates C. elegans dopaminergic neurodegeneration with implications for ERK-MAPK signaling
    Bwarenaba B Kautu
    Department of Biological Sciences, The University of Alabama, Tuscaloosa, AL 35487, United States
    Neurosci Lett 541:116-9. 2013
    ..These findings suggest that VA may exert its neuroprotective effect via ERK-MAPK, or alternately could act with MAPK signaling to additively provide dopaminergic neuroprotection...
  10. doi request reprint Functional analysis of VPS41-mediated neuroprotection in Caenorhabditis elegans and mammalian models of Parkinson's disease
    Adam J Harrington
    Department of Biological Sciences, The University of Alabama, Tuscaloosa, Alabama 35487, USA
    J Neurosci 32:2142-53. 2012
    ..Our results support hVPS41 as a potential novel therapeutic target for the treatment of synucleinopathies like PD...
  11. pmc The microtubule-associated protein, NUD-1, exhibits chaperone activity in vitro
    Lindsay M Faircloth
    Department of Biological Sciences, The University of Alabama, Tuscaloosa, AL 35487, USA
    Cell Stress Chaperones 14:95-103. 2009
    ....
  12. doi request reprint Modeling dopamine neuron degeneration in Caenorhabditis elegans
    Michelle L Tucci
    Department of Biological Sciences, The University of Alabama, Tuscaloosa, AL, USA
    Methods Mol Biol 793:129-48. 2011
    ..These techniques can be exploited to assess both chemical and genetic modifiers of toxicity, providing additional avenues to advance PD-related discoveries...
  13. ncbi request reprint An animal model to discern torsin function: suppression of protein aggregation in C. elegans
    Guy A Caldwell
    University of Alabama, Department of Biological Sciences, Tuscaloosa, Alabama, USA
    Adv Neurol 94:79-85. 2004
  14. pmc Ubiquitin conjugating enzymes participate in polyglutamine protein aggregation
    Rebecca A Howard
    Department of Biological Sciences, University of Alabama in Huntsville, Huntsville, AL 35899, USA
    BMC Cell Biol 8:32. 2007
    ..In this report, nematode and cell culture models for polyglutamine aggregation are used to investigate the role of the ubiquitin pathway in protein aggregation...
  15. ncbi request reprint Epileptic-like convulsions associated with LIS-1 in the cytoskeletal control of neurotransmitter signaling in Caenorhabditis elegans
    Shelli N Williams
    Department of Biological Sciences, The University of Alabama, Tuscaloosa, AL 35487 0344, USA
    Hum Mol Genet 13:2043-59. 2004
    ....
  16. pmc Chemical enhancement of torsinA function in cell and animal models of torsion dystonia
    Songsong Cao
    Department of Biological Sciences, The University of Alabama, Tuscaloosa, AL 35487, USA
    Dis Model Mech 3:386-96. 2010
    ....
  17. pmc The early-onset torsion dystonia-associated protein, torsinA, displays molecular chaperone activity in vitro
    Alexander J Burdette
    Department of Biological Sciences, The University of Alabama, Tuscaloosa, AL 35487 0344, USA
    Cell Stress Chaperones 15:605-17. 2010
    ....
  18. doi request reprint C. elegans as a model organism to investigate molecular pathways involved with Parkinson's disease
    Adam J Harrington
    Department of Biological Sciences, The University of Alabama, Tuscaloosa, Alabama 35487 0344, USA
    Dev Dyn 239:1282-95. 2010
    ....
  19. pmc Investigating bacterial sources of toxicity as an environmental contributor to dopaminergic neurodegeneration
    Kim A Caldwell
    Department of Biological Sciences, The University of Alabama, Tuscaloosa, Alabama, United States of America
    PLoS ONE 4:e7227. 2009
    ..Collectively, these data suggest the potential for exposures to the metabolites of specific common soil bacteria to possibly represent a contributory environmental component to PD...
  20. ncbi request reprint MEC-2 is recruited to the putative mechanosensory complex in C. elegans touch receptor neurons through its stomatin-like domain
    Shifang Zhang
    Department of Biological Sciences, Columbia University, New York, NY 10027, USA
    Curr Biol 14:1888-96. 2004
    ..The central portion of the integral membrane protein MEC-2 contains a stomatin-like region that is highly conserved from bacteria to mammals. The molecular function of this domain in MEC-2, however, is unknown...
  21. pmc A predictable worm: application of Caenorhabditis elegans for mechanistic investigation of movement disorders
    Paige M Dexter
    Department of Biological Sciences, The University of Alabama, Tuscaloosa, AL 35487, USA
    Neurotherapeutics 9:393-404. 2012
    ..Taken together, the application of C. elegans toward the evaluation of genetic modifiers for movement disorders research has predictive value and serves to accelerate the path forward for therapeutic interventions...
  22. ncbi request reprint The glycolytic enzyme, GPI, is a functionally conserved modifier of dopaminergic neurodegeneration in Parkinson's models
    Adam L Knight
    Department of Biological Sciences, The University of Alabama, Tuscaloosa, AL 35487, USA The Babraham Institute, Cambridge CB22 3AT, UK
    Cell Metab 20:145-57. 2014
    ..Collectively, these results support glucose metabolism as a conserved functional node at the intersection of proteostasis and neurodegeneration. ..
  23. pmc TorsinA rescues ER-associated stress and locomotive defects in C. elegans models of ALS
    Michelle L Thompson
    Department of Biological Sciences, The University of Alabama, Tuscaloosa, AL 35487, USA
    Dis Model Mech 7:233-43. 2014
    ..These results expand our understanding of proteostatic mechanisms influencing neuronal dysfunction in ALS, while simultaneously highlighting the potential for torsinA as a novel target for therapeutic development. ..
  24. pmc Invertebrate models of dystonia
    Kim A Caldwell
    Department of Biological Sciences, The University of Alabama, Tuscaloosa, AL 35487, USA
    Curr Neuropharmacol 11:16-29. 2013
    ..Moreover, the use of invertebrate models for the evaluation of DYT genetic loci and their genetic interaction networks has predictive value and can provide a path forward for therapeutic intervention. ..
  25. pmc Alpha-synuclein blocks ER-Golgi traffic and Rab1 rescues neuron loss in Parkinson's models
    Antony A Cooper
    School of Biological Sciences, University of Missouri Kansas City, Kansas City, MO 64110, USA
    Science 313:324-8. 2006
    ..Thus, synucleinopathies may result from disruptions in basic cellular functions that interface with the unique biology of particular neurons to make them especially vulnerable...
  26. ncbi request reprint Deletion of the ubiquitin ligase CHIP leads to the accumulation, but not the aggregation, of both endogenous phospho- and caspase-3-cleaved tau species
    Chad A Dickey
    Mayo Clinic College of Medicine, Jacksonville, Florida 32224, USA
    J Neurosci 26:6985-96. 2006
    ..Based on these findings, we propose that polyubiquitination of tau by CHIP may facilitate the formation of insoluble filamentous tau lesions...
  27. pmc The Parkinson's disease protein alpha-synuclein disrupts cellular Rab homeostasis
    Aaron D Gitler
    Whitehead Institute for Biomedical Research and Howard Hughes Medical Institute, Cambridge, MA 02142, USA
    Proc Natl Acad Sci U S A 105:145-50. 2008
    ..Thus, alpha-syn causes general defects in vesicle trafficking, to which dopaminergic neurons are especially sensitive...
  28. ncbi request reprint Role for NudC, a dynein-associated nuclear movement protein, in mitosis and cytokinesis
    Jonathan P Aumais
    Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
    J Cell Sci 116:1991-2003. 2003
    ..Our findings suggest that NudC functions in mitosis and cytokinesis, in part by regulating microtubule organization at the midzone and midbody...

Research Grants2

  1. Analysis of Torsin Protein Function in C. elegans
    GUY CALDWELL; Fiscal Year: 2003
    ....
  2. Use of C.elegans to Explore Bacterial Sources of Toxicity in Parkinson's Disease
    GUY CALDWELL; Fiscal Year: 2007
    ..C. elegans, a microscopic worm with precisely 8 dopamine neurons, shares about half of its genes with humans and represents an ideal system to rapidly examine potential sources environmental toxins that may influence development of PD. ..