Edward Calabrese

Summary

Affiliation: University of Massachusetts
Country: USA

Publications

  1. doi request reprint Hormesis: why it is important to toxicology and toxicologists
    Edward J Calabrese
    Department of Public Health, Environmental Health Sciences, Morrill I, N344, University of Massachusetts, Amherst, Massachusetts 01003, USA
    Environ Toxicol Chem 27:1451-74. 2008
  2. ncbi request reprint Alzheimer's disease drugs: an application of the hormetic dose-response model
    Edward J Calabrese
    Environmental Health Sciences Division, School of Public Health, University of Massachusetts, Amherst, Massachusetts 01003, USA
    Crit Rev Toxicol 38:419-51. 2008
  3. pmc The importance of hormesis to public health
    Ralph Cook
    RRC Consulting, LLC, Midland, Michigan, USA
    Environ Health Perspect 114:1631-5. 2006
  4. ncbi request reprint How radiotherapy was historically used to treat pneumonia: could it be useful today?
    Edward J Calabrese
    Department of Public Health, Environmental Health Sciences, University of Massachusetts, Amherst, Massachusetts
    Yale J Biol Med 86:555-70. 2013
  5. doi request reprint Biphasic dose responses in biology, toxicology and medicine: accounting for their generalizability and quantitative features
    Edward J Calabrese
    Environmental Health Sciences Program, School of Public Health, University of Massachusetts, Amherst, MA 01003, USA Electronic address
    Environ Pollut 182:452-60. 2013
  6. ncbi request reprint How the US National Academy of Sciences misled the world community on cancer risk assessment: new findings challenge historical foundations of the linear dose response
    Edward J Calabrese
    Department of Public Health, Environmental Health Sciences, University of Massachusetts, Morrill I, N344, Amherst, MA, 01003, USA
    Arch Toxicol 87:2063-81. 2013
  7. doi request reprint Hormetic mechanisms
    Edward J Calabrese
    Department of Public Health, Environmental Health Sciences, University of Massachusetts, Amherst, MA 01003, USA
    Crit Rev Toxicol 43:580-606. 2013
  8. pmc Stress responses, vitagenes and hormesis as critical determinants in aging and longevity: Mitochondria as a "chi"
    Carolin Cornelius
    Department of Chemistry University of Catania, Viale Andrea Doria, 95100 Catania, Italy
    Immun Ageing 10:15. 2013
  9. doi request reprint Origin of the linearity no threshold (LNT) dose-response concept
    Edward J Calabrese
    Department of Public Health, Environmental Health Sciences, University of Massachusetts, Morrill I, N344, Amherst, MA, 01003, USA
    Arch Toxicol 87:1621-33. 2013
  10. doi request reprint Low dose radiation therapy (LD-RT) is effective in the treatment of arthritis: animal model findings
    Edward J Calabrese
    University of Massachusetts, Public Health EHS, Morrill I, Amherst, Massachusetts 01003, USA
    Int J Radiat Biol 89:287-94. 2013

Detail Information

Publications106 found, 100 shown here

  1. doi request reprint Hormesis: why it is important to toxicology and toxicologists
    Edward J Calabrese
    Department of Public Health, Environmental Health Sciences, Morrill I, N344, University of Massachusetts, Amherst, Massachusetts 01003, USA
    Environ Toxicol Chem 27:1451-74. 2008
    ....
  2. ncbi request reprint Alzheimer's disease drugs: an application of the hormetic dose-response model
    Edward J Calabrese
    Environmental Health Sciences Division, School of Public Health, University of Massachusetts, Amherst, Massachusetts 01003, USA
    Crit Rev Toxicol 38:419-51. 2008
    ..Finally, the significance of the U-shaped dose response is critical for successful clinical application, since it defines the therapeutic window...
  3. pmc The importance of hormesis to public health
    Ralph Cook
    RRC Consulting, LLC, Midland, Michigan, USA
    Environ Health Perspect 114:1631-5. 2006
    ..The effects that occur at various points along this curve can be interpreted as beneficial or detrimental, depending on the biological or ecologic context in which they occur...
  4. ncbi request reprint How radiotherapy was historically used to treat pneumonia: could it be useful today?
    Edward J Calabrese
    Department of Public Health, Environmental Health Sciences, University of Massachusetts, Amherst, Massachusetts
    Yale J Biol Med 86:555-70. 2013
    ..The capacity of low doses of X-rays to suppress inflammatory responses is a significant new concept with widespread biomedical and therapeutic applications. ..
  5. doi request reprint Biphasic dose responses in biology, toxicology and medicine: accounting for their generalizability and quantitative features
    Edward J Calabrese
    Environmental Health Sciences Program, School of Public Health, University of Massachusetts, Amherst, MA 01003, USA Electronic address
    Environ Pollut 182:452-60. 2013
    ..The integration of the hormetic dose response within an allometric framework provides, for the first time, an explanation for both the generality and the quantitative features of the hormetic dose response. ..
  6. ncbi request reprint How the US National Academy of Sciences misled the world community on cancer risk assessment: new findings challenge historical foundations of the linear dose response
    Edward J Calabrese
    Department of Public Health, Environmental Health Sciences, University of Massachusetts, Morrill I, N344, Amherst, MA, 01003, USA
    Arch Toxicol 87:2063-81. 2013
    ....
  7. doi request reprint Hormetic mechanisms
    Edward J Calabrese
    Department of Public Health, Environmental Health Sciences, University of Massachusetts, Amherst, MA 01003, USA
    Crit Rev Toxicol 43:580-606. 2013
    ....
  8. pmc Stress responses, vitagenes and hormesis as critical determinants in aging and longevity: Mitochondria as a "chi"
    Carolin Cornelius
    Department of Chemistry University of Catania, Viale Andrea Doria, 95100 Catania, Italy
    Immun Ageing 10:15. 2013
    ..Here we focus on possible signaling mechanisms involved in the activation of vitagenes resulting in enhanced defense against energy and stress resistance homeostasis dysiruption with consequent impact on longevity processes...
  9. doi request reprint Origin of the linearity no threshold (LNT) dose-response concept
    Edward J Calabrese
    Department of Public Health, Environmental Health Sciences, University of Massachusetts, Morrill I, N344, Amherst, MA, 01003, USA
    Arch Toxicol 87:1621-33. 2013
    ..The LNT concept was later generalized to chemical carcinogen risk assessment and used by public health and regulatory agencies worldwide. ..
  10. doi request reprint Low dose radiation therapy (LD-RT) is effective in the treatment of arthritis: animal model findings
    Edward J Calabrese
    University of Massachusetts, Public Health EHS, Morrill I, Amherst, Massachusetts 01003, USA
    Int J Radiat Biol 89:287-94. 2013
    ..This paper provides a critical assessment of the hypothesis that low doses of ionizing radiation may be potentially effective in the treatment of inflammatory conditions, with particular focus on arthritis...
  11. doi request reprint Reduction of arthritic symptoms by low dose radiation therapy (LD-RT) is associated with an anti-inflammatory phenotype
    Edward J Calabrese
    University of Massachusetts, Public Health EHS, Morrill I, Amherst, Massachusetts 01003, USA
    Int J Radiat Biol 89:278-86. 2013
    ..The aim of this paper was to provide an integrative mechanistic appraisal to account for consistent observations of protective effects of ionizing radiation on the occurrence/ progression of arthritis in multiple animal models...
  12. doi request reprint Historical foundations of wound healing and its potential for acceleration: dose-response considerations
    Edward J Calabrese
    Department of Public Health, Environmental Health Sciences, University of Massachusetts, Amherst, MA 01003, USA
    Wound Repair Regen 21:180-93. 2013
    ....
  13. doi request reprint Hormesis: Toxicological foundations and role in aging research
    Edward J Calabrese
    School of Public Health and Health Sciences, Department of Public Health, Morrill I, N344, University of Massachusetts, Amherst, MA 01003, United States
    Exp Gerontol 48:99-102. 2013
    ....
  14. doi request reprint NEPA, EPA and risk assessment: Has EPA lost its way?
    Edward J Calabrese
    School of Public Health and Health Sciences, Department of Public Health, Environmental Health Sciences, University of Massachusetts, Amherst, MA 01003, USA
    Regul Toxicol Pharmacol 64:267-8. 2012
    ..It is time for regulatory agencies such as EPA to incorporate both harm and benefit within its risk assessment process...
  15. ncbi request reprint P-glycoprotein efflux transporter activity often displays biphasic dose-response relationships
    Edward J Calabrese
    Environmental Health Sciences Division, School of Public Health, University of Massachusetts, Amherst, Massachusetts 01003, USA
    Crit Rev Toxicol 38:473-87. 2008
    ..These findings provide further support for the generalizability of the hormetic dose-response model while having important biological and clinical implications, including transport through the blood-brain barrier...
  16. ncbi request reprint Stress biology and hormesis: the Yerkes-Dodson law in psychology--a special case of the hormesis dose response
    Edward J Calabrese
    Environmental Health Sciences Division, School of Public Health, University of Massachusetts, Amherst, Massachusetts 01003, USA
    Crit Rev Toxicol 38:453-62. 2008
    ..The conceptual integration of the Yerkes-Dodson Law within the hormetic dose response framework adds further support for the generalization of the hormesis concept...
  17. doi request reprint An assessment of anxiolytic drug screening tests: hormetic dose responses predominate
    Edward J Calabrese
    Department of Public Health, School of Public Health and Health Sciences, Environmental Health Sciences Division, University of Massachusetts, Amherst, Massachusetts 01003, USA
    Crit Rev Toxicol 38:489-542. 2008
    ....
  18. doi request reprint Pharmacological enhancement of neuronal survival
    Edward J Calabrese
    Department of Public Health, Environmental Health Sciences, University of Massachusetts, Amherst, Massachusetts 01003, USA
    Crit Rev Toxicol 38:349-89. 2008
    ..That neuroprotective agents display similar dose-response relationships regardless of experimental system, potency, and endpoint is an important observation with widespread biomedical and clinical implications...
  19. doi request reprint Neuroscience and hormesis: overview and general findings
    Edward J Calabrese
    Department of Public Health, Environmental Health Sciences, University of Massachusetts, Amherst, Massachusetts 01003, USA
    Crit Rev Toxicol 38:249-52. 2008
    ....
  20. doi request reprint Another California milestone: the first application of hormesis in litigation and regulation
    Edward J Calabrese
    Department of Public Health, Environmental Health Sciences, University of Massachusetts, Amherst, Massachusetts 01003, USA
    Int J Toxicol 27:31-3. 2008
    ..This occurred in California within the context of an assessment of alleged continuing smelter contamination nearly a century ago...
  21. ncbi request reprint Converging concepts: adaptive response, preconditioning, and the Yerkes-Dodson Law are manifestations of hormesis
    Edward J Calabrese
    Department of Public Health, Environmental Health Sciences, Morrill I, N344, University of Massachusetts, Amherst, MA 01003, USA
    Ageing Res Rev 7:8-20. 2008
    ....
  22. ncbi request reprint Elliott's ethics of expertise proposal and application: a dangerous precedent
    Edward J Calabrese
    Department of Public Health, Environmental Health Sciences, University of Massachusetts, Pleasant Street, Morrill I, N344, Amherst, MA 01003, USA
    Sci Eng Ethics 13:139-45. 2007
    ....
  23. ncbi request reprint Astrocytes: adaptive responses to low doses of neurotoxins
    Edward J Calabrese
    Environmental Health Sciences Division, School of Public Health, University of Massachusetts, Amherst, Massachusetts 01003, USA
    Crit Rev Toxicol 38:463-71. 2008
    ....
  24. ncbi request reprint Threshold Dose--Response Model--RIP: 1911 to 2006
    Edward J Calabrese
    Environmental Health Sciences, University of Massachusetts, North Pleassant St Amherst MA 01003, USA
    Bioessays 29:686-8. 2007
    ..In fact, so poorly does this model predict low-dose responses that the idea arose that it should receive a symbolic burial recounting its achievements and failings, hence this obituary...
  25. ncbi request reprint Biological stress response terminology: Integrating the concepts of adaptive response and preconditioning stress within a hormetic dose-response framework
    Edward J Calabrese
    School of Public Health, Morrill I, N344, University of Massachusetts, Amherst, MA 01003, USA
    Toxicol Appl Pharmacol 222:122-8. 2007
    ....
  26. ncbi request reprint Hormesis outperforms threshold model in National Cancer Institute antitumor drug screening database
    Edward J Calabrese
    Department of Public Health, Environmental Health Sciences Program, Morrill I, N344, University of Massachusetts, Amherst, Massachusetts 01003, USA
    Toxicol Sci 94:368-78. 2006
    ..The data call for the rejection of the threshold model for low-dose prediction, and they support the hormetic model as the default model for scientific interpretation of low-dose toxicological responses...
  27. ncbi request reprint The failure of dose-response models to predict low dose effects: a major challenge for biomedical, toxicological and aging research
    Edward J Calabrese
    Department of Public Health, Environmental Health Sciences, University of Massachusetts, Morrill I, N344 Amherst, MA 01003, USA
    Biogerontology 7:119-22. 2006
    ..These findings have particular relevance to the area of biogerontology since this discipline often resides at the pharmacological-toxicological interface...
  28. ncbi request reprint Drug development and hormesis: changing conceptual understanding of the dose response creates new challenges and opportunities for more effective drugs
    Edward J Calabrese
    Department of Public Health, Environmental Health Sciences Program, Morrill I, N344, University of Massachusetts, Amherst, MA 01003, USA
    Curr Opin Drug Discov Devel 9:117-23. 2006
    ....
  29. doi request reprint Modulation of the epileptic seizure threshold: implications of biphasic dose responses
    Edward J Calabrese
    Department of Public Health, School of Public Health and Health Sciences, Environmental Health Sciences Divison, University of Massachusetts, Amherst, Massachusetts 01003, USA
    Crit Rev Toxicol 38:543-56. 2008
    ..These findings support the generalizability of the hormetic dose-response concept and may have important implications for the discovery of antiseizure drugs and their clinical evaluation...
  30. pmc Hormesis and medicine
    Edward J Calabrese
    Department of Public Health, Environmental Health Sciences, Morrill I, N344, University of Massachusetts, Amherst, MA 01003, USA
    Br J Clin Pharmacol 66:594-617. 2008
    ....
  31. doi request reprint Toxicology rewrites its history and rethinks its future: giving equal focus to both harmful and beneficial effects
    Edward J Calabrese
    School of Public Health and Health Sciences, Department of Public Health, University of Massachusetts, Amherst, Massachusetts, USA
    Environ Toxicol Chem 30:2658-73. 2011
    ..Toxicology needs to assess the entire dose-response continuum, incorporating both harmful and beneficial effects into the risk assessment process...
  32. doi request reprint Key studies used to support cancer risk assessment questioned
    Edward J Calabrese
    Environmental Health Sciences Division, Department of Public Health, School of Public Health and Health Sciences, University of Massachusetts, Amherst, USA
    Environ Mol Mutagen 52:595-606. 2011
    ....
  33. doi request reprint Muller's Nobel lecture on dose-response for ionizing radiation: ideology or science?
    Edward J Calabrese
    Environmental Health Sciences, Department of Public Health, School of Public Health and Health Sciences, University of Massachusetts, Amherst, MA 01003, USA
    Arch Toxicol 85:1495-8. 2011
    ..This finding is of historical importance since Muller's Nobel Lecture gained considerable international attention and is a turning point in the acceptance of the linearity model in risk assessment for germ cell mutations and carcinogens...
  34. doi request reprint The hormesis database: the occurrence of hormetic dose responses in the toxicological literature
    Edward J Calabrese
    Department of Public Health, Environmental Health Sciences Division, School of Public Health an Health Sciences, Morrill I, N344, University of Massachusetts, Amherst, MA 01003, USA
    Regul Toxicol Pharmacol 61:73-81. 2011
    ....
  35. pmc Hormesis provides a generalized quantitative estimate of biological plasticity
    Edward J Calabrese
    School of Public Health and Health Sciences, Department of Environmental Health Sciences, University of Massachusetts, Morrill I, N344, Amherst, MA, 01003, USA
    J Cell Commun Signal 5:25-38. 2011
    ..The quantitative features of plasticity are described by the hormesis dose response model. These findings have important biological, biomedical and evolutionary implications...
  36. doi request reprint Dose response biology: the case of resveratrol
    Edward J Calabrese
    Department of Public Health, Environmental Health Sciences, University of Massachusetts, Amherst, MA 01003, USA
    Hum Exp Toxicol 29:1034-7. 2010
    ....
  37. ncbi request reprint Evaluating homeopathic drugs within a biomedical framework
    Edward J Calabrese
    Environmental Health Sciences Program, School of Public Health, University of Massachusetts, Amherst, Massachusetts 01003, USA
    Hum Exp Toxicol 29:545-9. 2010
    ..This developmental framework can provide a scientific 'point of contact' between the homeopathic and biomedical communities, which has long been lacking...
  38. ncbi request reprint Homeopathy: clarifying its relationship to hormesis
    Edward J Calabrese
    Environmental Health Sciences Program, School of Public Health, University of Massachusetts, Amherst, Massachusetts 01003, USA
    Hum Exp Toxicol 29:531-6. 2010
    ..This experimental framework (along with a pre-conditioning model developed by Bellavite) provides a possible vehicle by which certain aspect(s) of homeopathy may be integrated into mainstream biomedical assessment and clinical practice...
  39. doi request reprint Hormesis is central to toxicology, pharmacology and risk assessment
    Edward J Calabrese
    Department of Public Health, Environmental Health Sciences Division, University of Massachusetts, Amherst, MA, USA
    Hum Exp Toxicol 29:249-61. 2010
    ..It is expected that as low dose responses come to dominate toxicological research that risk assessment practices will incorporate hormetic concepts in the standard setting process...
  40. ncbi request reprint Hormesis in high-throughput screening of antibacterial compounds in E coli
    Edward J Calabrese
    Department of Public Health, Environmental Health Sciences, University of Massachusetts, Amherst, MA, USA
    Hum Exp Toxicol 29:667-77. 2010
    ....
  41. ncbi request reprint The road to linearity: why linearity at low doses became the basis for carcinogen risk assessment
    Edward J Calabrese
    Environmental Health Sciences Division, Department of Public Health, University of Massachusetts, Morrill I, N344, Amherst, MA 01003, USA
    Arch Toxicol 83:203-25. 2009
    ..These observations suggest that while scientific disciplines are self correcting, that regulatory 'science' fails to display the same self-correcting mechanism despite contradictory data...
  42. ncbi request reprint Getting the dose-response wrong: why hormesis became marginalized and the threshold model accepted
    Edward J Calabrese
    Department of Public Health, Environmental Health Sciences Division, School of Public Health and Health Sciences, University of Massachusetts, Morrill I, N344, Amherst, MA 01003, USA
    Arch Toxicol 83:227-47. 2009
    ..This analysis challenges a key foundation upon which biological, biomedical and clinical science rest...
  43. doi request reprint Hormesis and plant biology
    Edward J Calabrese
    Department of Public Health, Environmental Health Sciences Division, Pleasant Street, Morrill I, N344, University of Massachusetts, Amherst, MA 01003, USA
    Environ Pollut 157:42-8. 2009
    ..The database establishes that hormetic dose responses commonly occur in plants, are broadly generalizable, and have quantitative features similar to hormetic dose responses found for animals...
  44. ncbi request reprint Addiction and dose response: the psychomotor stimulant theory of addiction reveals that hormetic dose responses are dominant
    Edward J Calabrese
    Department of Public Health, School of Public Health and Health Sciences, Environmental Health Sciences Division, University of Massachusetts, Amherst, Massachusetts 01003, USA
    Crit Rev Toxicol 38:599-617. 2008
    ....
  45. ncbi request reprint Pain and u-shaped dose responses: occurrence, mechanisms, and clinical implications
    Edward J Calabrese
    Department of Public Health, School of Public Health and Health Sciences, Environmental Health Sciences Division, University of Massachusetts, Amherst, Massachusetts 01003, USA
    Crit Rev Toxicol 38:579-90. 2008
    ..These findings have important implications for drug discovery, development, and clinical evaluation...
  46. pmc Hormesis: a conversation with a critic
    Edward J Calabrese
    Department of Public Health, Environmental Health Sciences Division, University of Massachusetts, Amherst, MA 01003 USA
    Environ Health Perspect 117:1339-43. 2009
    ..Environ Health Perspect 117:1333-1338 (2009)], which principally concerns studies by me and my colleagues concerning the frequency of hormesis in toxicology...
  47. ncbi request reprint Cancer biology and hormesis: human tumor cell lines commonly display hormetic (biphasic) dose responses
    Edward J Calabrese
    Environmental Health Sciences, University of Massachusetts, Amherst 01003, USA
    Crit Rev Toxicol 35:463-582. 2005
    ....
  48. ncbi request reprint Historical blunders: how toxicology got the dose-response relationship half right
    E J Calabrese
    Environmental Health Sciences Program, School of Public Health, University of Massachusetts, Amherst, 01003, USA
    Cell Mol Biol (Noisy-le-grand) 51:643-54. 2005
    ....
  49. ncbi request reprint Opiates: biphasic dose responses
    E J Calabrese
    Department of Environmental Health Sciences, School of Public Health and Health Sciences, University of Massachusetts, Amherst 01003, USA
    Crit Rev Toxicol 31:585-604. 2001
    ..Mechanistic assessments were conducted for most biphasic dose-response relationships and are addressed in detail...
  50. ncbi request reprint Amyloid beta-peptide: biphasic dose responses
    E J Calabrese
    Department of Environmental Health Sciences, School of Public Health and Health Sciences, University of Massachusetts, Amherst 01003, USA
    Crit Rev Toxicol 31:605-6. 2001
    ..These findings suggest the critical role of dose in understanding disease causation and clinical therapeutics for Alzheimer's disease...
  51. ncbi request reprint The Single Exposure Carcinogen Database: assessing the circumstances under which a single exposure to a carcinogen can cause cancer
    E J Calabrese
    Environmental Health Sciences, School of Public Health, University of Massachusetts, Amherst 01003, USA
    Toxicol Sci 50:169-85. 1999
    ....
  52. ncbi request reprint Ethanol and hormesis
    Edward J Calabrese
    Department of Environmental Health Sciences, Morrill Science Center, University of Massachusetts, Amherst, MA 01003, USA
    Crit Rev Toxicol 33:407-24. 2003
    ..These findings have important implications affecting study design, animal model, and endpoint selection as well as clinical applications...
  53. ncbi request reprint Peptides and hormesis
    Edward J Calabrese
    Department of Environmental Health Sciences, University of Massachusetts, Amherst, MA 01003, USA
    Crit Rev Toxicol 33:355-405. 2003
    ..These findings strongly suggest that hormetic-like biphasic dose responses represent a broadly generalizable biological phenomenon...
  54. ncbi request reprint Chemotherapeutics and hormesis
    Edward J Calabrese
    Department of Environmental Health Sciences, Morrill Science Center, University of Massachusetts, Amherst, MA 01003, USA
    Crit Rev Toxicol 33:305-53. 2003
    ....
  55. ncbi request reprint The effects of gamma rays on longevity
    E J Calabrese
    Department of Environmental Health Sciences, Morrill Science Center, School of Public Health, University of Massachusetts, Amherst, MA 01003, USA
    Biogerontology 1:309-19. 2000
    ..The underlying mechanisms affecting the apparent enhancement in longevity are believed to result from the stimulation of hematopoietic and immune systems following an initial low level chronic injury to the bone marrow...
  56. ncbi request reprint The effects of diisopropylmethylphosphonate, a by-product of the production of sarin and a contaminant in drinking water at the Rocky Mountain Arsenal, on female mink
    Edward J Calabrese
    Department of Environmental Health Science, Morrill I, N344, School of Public Health and Health Science, University of Massachusetts, Amherst, MA 01003, USA
    Regul Toxicol Pharmacol 37:191-201. 2003
    ..concerning the effects of DIMP on mink as well as identify for the first time that pregnancy/lactation in mink is a risk factor in the induction of thymic atrophy and the elevation of serum ALT/AST...
  57. ncbi request reprint Defining hormesis
    E J Calabrese
    Environmental Health Sciences, University of Massachusetts, Amherst 01003, USA
    Hum Exp Toxicol 21:91-7. 2002
    ....
  58. ncbi request reprint Risk communication and the challenge of hormesis
    Edward Calabrese
    UMASS School of Public Health and Health Sciences, Amherst, MA, USA
    Hum Exp Toxicol 22:1. 2003
  59. ncbi request reprint Applications of hormesis in toxicology, risk assessment and chemotherapeutics
    Edward J Calabrese
    Department of Environmental Health Sciences, School of Public Health and Health Sciences, University of Massachusetts, Amherst, MA 10003, USA
    Trends Pharmacol Sci 23:331-7. 2002
    ..In this article, a broad range of basic issues associated with the acceptance of U-shaped dose responses as central to toxicology, pharmacology and their applications to risk assessment and medicine will be discussed...
  60. ncbi request reprint Hormesis: the dose-response revolution
    Edward J Calabrese
    Environmental Health Sciences, University of Massachusetts, Amherst, Massachusetts 01003, USA
    Annu Rev Pharmacol Toxicol 43:175-97. 2003
    ..g., concept of NOAEL (no observed adverse effect level), low dose modeling, recognition of beneficial as well as harmful responses] for all agents, and (c) the harmonization of cancer and noncancer risk assessment...
  61. ncbi request reprint The effects of diisopropylmethylphosphonate on female mink: how medical intervention biased mortality data
    Edward J Calabrese
    Department of Environmental Health Science, University of Massachusetts, Morrill I, N344 Amherst, MA 01003 5712, USA
    Regul Toxicol Pharmacol 38:260-8. 2003
    ..These findings indicate that the DIMP treated female mink were more likely to have benefited from the intervention than the controls. The intervention, therefore, reduced the likelihood of observing treatment-related effects...
  62. ncbi request reprint Dopamine: biphasic dose responses
    E J Calabrese
    Department of Environmental Health Sciences, School of Public Health and Health Sciences, University of Massachusetts, Amherst 01003, USA
    Crit Rev Toxicol 31:563-83. 2001
    ..Mechanistic studies suggested that the stimulatory and inhibitory effects of dopamine are mediated by different receptors or receptor subtypes having opposite actions and different ligand affinities...
  63. ncbi request reprint Hormesis: from marginalization to mainstream: a case for hormesis as the default dose-response model in risk assessment
    Edward J Calabrese
    Environmental Health Sciences, University of Massachusetts, Morrill I, N344, Amherst, MA 01003, USA
    Toxicol Appl Pharmacol 197:125-36. 2004
    ..The selection of the hormetic model as the default model in risk assessment for noncarcinogens and specifically for carcinogens would have a profound impact on the practice of risk assessment and its societal implications...
  64. ncbi request reprint Paradigm lost, paradigm found: the re-emergence of hormesis as a fundamental dose response model in the toxicological sciences
    Edward J Calabrese
    Environmental Health Sciences, School of Public Health, Morrill I, N344, University of Massachusetts, Amherst, MA 01003, USA
    Environ Pollut 138:379-411. 2005
    ..Such historical and technical blind spots lead the field of toxicology to not only reject an established dose-response model (hormesis), but also the model that was more common and fundamental than those that the field accepted...
  65. ncbi request reprint Hormesis: U-shaped dose responses and their centrality in toxicology
    E J Calabrese
    Department of Environmental Health Sciences, School of Public Health and Health Sciences, University of Massachusetts, Amherst, MA 01003, USA
    Trends Pharmacol Sci 22:285-91. 2001
    ....
  66. ncbi request reprint Hormesis: a generalizable and unifying hypothesis
    E J Calabrese
    Department of Environmental Health Sciences, School of Public Health and Health Sciences, University of Massachusetts, Amherst 01003, USA
    Crit Rev Toxicol 31:353-424. 2001
    ....
  67. ncbi request reprint Overcompensation stimulation: a mechanism for hormetic effects
    E J Calabrese
    Department of Environmental Health Sciences, School of Public Health and Health Sciences, University of Massachusetts, Amherst 01003, USA
    Crit Rev Toxicol 31:425-70. 2001
    ..The finding also demonstrates the significant role of temporal factors in the assessment of dose response relationships...
  68. ncbi request reprint Hormetic dose-response relationships in immunology: occurrence, quantitative features of the dose response, mechanistic foundations, and clinical implications
    Edward J Calabrese
    Environmental Health and Health Sciences, University of Massachusetts, Amherst, Massachusetts 01003, USA
    Crit Rev Toxicol 35:89-295. 2005
    ....
  69. ncbi request reprint Prostaglandins: biphasic dose responses
    E J Calabrese
    Department of Environmental Health Sciences, School of Public Health and Health Sciences, University of Massachusetts, Amherst 01003, USA
    Crit Rev Toxicol 31:475-87. 2001
    ..These findings have considerable implications for the understanding of basic biological regulatory processes as well as clinical practices...
  70. ncbi request reprint Nitric oxide: biphasic dose responses
    E J Calabrese
    Department of Environmental Health Sciences, School of Public Health and Health Sciences, University of Massachusetts, Amherst 01003, USA
    Crit Rev Toxicol 31:489-501. 2001
    ..5 to 500-fold, the majority was < or = 10-fold. These findings indicate that biphasic dose-response relationships are common manifestations of the NO-induced effects...
  71. ncbi request reprint Androgens: biphasic dose responses
    E J Calabrese
    Department of Environmental Health Sciences, School of Public Health and Health Sciences, University of Massachusetts, Amherst 01003, USA
    Crit Rev Toxicol 31:517-22. 2001
    ..Testosterone production was also biphasically affected by prolactin that was administered to adult testicular cells in vitro...
  72. ncbi request reprint The occurrence of hormetic dose responses in the toxicological literature, the hormesis database: an overview
    Edward J Calabrese
    Environmental Health Sciences, University of Massachusetts, Amherst, MA 01003, USA
    Toxicol Appl Pharmacol 202:289-301. 2005
    ....
  73. ncbi request reprint Adrenergic receptors: biphasic dose responses
    E J Calabrese
    Department of Environmental Health Sciences, School of Public Health and Health Sciences, University of Massachusetts, Amherst 01003, USA
    Crit Rev Toxicol 31:523-38. 2001
    ..The range of stimulatory responses was generally within 10- to 1000-fold, except for the platelet aggregation endpoint where the range was 10(3) to 10(5)...
  74. pmc Hormesis: a revolution in toxicology, risk assessment and medicine
    Edward J Calabrese
    University of Massachusetts School of Public Health in Amherst, MA, USA
    EMBO Rep 5:S37-40. 2004
  75. ncbi request reprint Adenosine: biphasic dose responses
    E J Calabrese
    Department of Environmental Health Sciences, School of Public Health and Health Sciences, University of Massachusetts, Amherst 01003, USA
    Crit Rev Toxicol 31:539-51. 2001
    ..In general, the maximum stimulatory response was 2.5-fold or less than controls, while the stimulatory concentration range was quite variable ranging from 10- to 10(5)-fold...
  76. doi request reprint Evidence for hormesis in mutagenicity dose-response relationships
    Edward J Calabrese
    Department of Public Health, University of Massachusetts, Amherst, MA 01003, USA
    Mutat Res 726:91-7. 2011
    ..Only 2.2% (1/46) of the assays satisfied the evaluative criteria for hormesis. In conclusion, these data support a hormetic model for TA100, whereas the responses for TA97 and TA98 are consistent with a threshold dose-response model...
  77. doi request reprint Resveratrol commonly displays hormesis: occurrence and biomedical significance
    Edward J Calabrese
    Department of Public Health, Environmental Health Sciences, University of Massachusetts, Amherst, MA 01003, USA
    Hum Exp Toxicol 29:980-1015. 2010
    ..Despite consistent occurrence of hormetic dose responses of resveratrol in a wide range of biomedical models, epidemiologic and clinical trials are needed to assess the nature of its dose-response in humans...
  78. ncbi request reprint Hormesis: changing view of the dose-response, a personal account of the history and current status
    Edward J Calabrese
    Department of Environmental Health Sciences, School of Public Health and Health Sciences, University of Massachusetts, Amherst, MA 01003, USA
    Mutat Res 511:181-9. 2002
    ....
  79. ncbi request reprint Hormesis and high-risk groups
    Edward J Calabrese
    Department of Environmental Health Sciences, School of Public Health and Health Sciences, University of Massachusetts, Amherst 01003 5712, USA
    Regul Toxicol Pharmacol 35:414-28. 2002
    ..Thus, the capacity to display hormetic effects is one of a variety of factors affecting differential susceptibility to xenobiotics and needs to be addressed within the hazard assessment process...
  80. doi request reprint Hormesis and the law: introduction
    Edward J Calabrese
    Department of Public Health, Environmental Health Sciences, University of Massachusetts, Amherst, MA 01003, USA
    Hum Exp Toxicol 27:95-6. 2008
  81. doi request reprint Enhancing and regulating neurite outgrowth
    Edward J Calabrese
    Department of Public Health, Environmental Health Sciences, University of Massachusetts, Amherst, Massachusetts 01003, USA
    Crit Rev Toxicol 38:391-418. 2008
    ..The findings also display an essential role for hormetic dose-response relationships in normal neuronal-based developmental and tissue repair processes...
  82. doi request reprint Dose-response features of neuroprotective agents: an integrative summary
    Edward J Calabrese
    Department of Public Health, Environmental Health Sciences, University of Massachusetts, Amherst, Massachusetts 01003, USA
    Crit Rev Toxicol 38:253-348. 2008
    ..Mechanisms that account for numerous hormetic dose responses of neuroprotective agents are summarized, as well as the clinical implications of specific experimental findings...
  83. ncbi request reprint Toxicological awakenings: the rebirth of hormesis as a central pillar of toxicology
    Edward J Calabrese
    Environmental Health Sciences, Morrill I, N344, University of Massachusetts, Amherst, MA 01003, USA
    Toxicol Appl Pharmacol 204:1-8. 2005
    ..Acceptance of the possibility of hormesis has the potential to profoundly affect the practice of toxicology and risk assessment, especially with respect to carcinogen assessment...
  84. doi request reprint BELLE: an evolving legacy
    Edward J Calabrese
    Department of Public Health, Environmental Health Sciences Division, University of Massachusetts, Amherst, Massachusetts 01003, USA
    Hum Exp Toxicol 29:247-8. 2010
    ..A brief overview of how BELLE was created is provided...
  85. ncbi request reprint U-shaped dose response in behavioral pharmacology: historical foundations
    Edward J Calabrese
    Department of Public Health, School of Public Health and Health Sciences, Environmental Health Sciences Division, University of Massachusetts, Amherst, Massachusetts 01003, USA
    Crit Rev Toxicol 38:591-8. 2008
    ..The article provides a reinterpretation of the biphasic dose response in the fixed interval (FI) schedule of reinforcement...
  86. doi request reprint Hormesis predicts low-dose responses better than threshold models
    Edward J Calabrese
    Department of Public Health, Environmental Health Sciences Division, University of Massachusetts, Amherst, Massachusetts 01003, USA
    Int J Toxicol 27:369-78. 2008
    ..2006, Toxicol. Sci. 94:368-378). Taken together, the analyses provide strong evidence for hormesis, a phenomenon with a broad range of biomedical and toxicological implications...
  87. ncbi request reprint The hormetic dose-response model is more common than the threshold model in toxicology
    Edward J Calabrese
    Department of Environmental Health Sciences, University of Massachusetts, Amherst, Massachusetts 01003, USA
    Toxicol Sci 71:246-50. 2003
    ..These findings may affect numerous aspects of toxicological and biological/biomedical research related to dose-response relationships, including study design, risk assessment, as well as chemotherapeutic strategies...
  88. ncbi request reprint Hormesis: how it could affect the risk assessment process
    Edward J Calabrese
    Environmental Health Sciences, Morrill I, N344, University of Massachusetts, Amherst, MA 01003, USA
    Hum Exp Toxicol 24:265-70. 2005
    ..By dismissing hormesis, regulatory agencies such as EPA deny the public the opportunity for optimal health and avoidance of disease...
  89. ncbi request reprint Toxicology rethinks its central belief
    Edward J Calabrese
    Department of Environmental Health Sciences, University of Massachusetts, Amherst, Massachusetts 01003, USA
    Nature 421:691-2. 2003
  90. doi request reprint Bioavailability of arsenic in soil: pilot study results and design considerations
    Edward J Stanek
    Division of Biostatistics and Epidemiology, School of Public Health and Health Sciences, Arnold House, University of Massachusetts, Amherst, Massachusetts 01003, USA
    Hum Exp Toxicol 29:945-60. 2010
    ..7% (95% CI [36.2%, 61.3%]). Relative to bioavailability of As from food/beverage sources, soil-As is estimated to be 54.3% (95% CI [40.3%, 68.4%]) as bioavailable...
  91. doi request reprint Drug therapies for stroke and traumatic brain injury often display U-shaped dose responses: occurrence, mechanisms, and clinical implications
    Edward J Calabrese
    Department of Public Health, School of Public Health and Health Sciences, Environmental Health Sciences Division, University of Massachusetts, Amherst, Massachusetts 01003, USA
    Crit Rev Toxicol 38:557-77. 2008
    ..These findings suggest that U-shaped dose responses in animal stroke/TBI models may be a general occurrence and have significant implications for drug discovery, drug development, and clinical practice...
  92. ncbi request reprint Hormesis--basic, generalizable, central to toxicology and a method to improve the risk-assessment process
    Edward J Calabrese
    School of Public Health, Morrill I, N344, University of Massachusetts, Amherst, MA 01003, USA
    Int J Occup Environ Health 10:466-7. 2004
    ..The author addresses issues relating to the definition of hormesis, the relationship of hormesis to risk assessment and risk management, and the generalizability of hormesis within the toxicological literature...
  93. ncbi request reprint Should hormesis be the default model in risk assessment?
    Edward J Calabrese
    Environmental Health Sciences, University of Massachusetts, Amherst, MA, USA
    Hum Exp Toxicol 24:243. 2005
  94. ncbi request reprint Inorganics and hormesis
    Edward J Calabrese
    Department of Environmental Health Sciences, Morrill Science Center, University of Massachusetts, Amherst, MA 01003, USA
    Crit Rev Toxicol 33:215-304. 2003
    ..The hormetic dose response should be seen as a reliable feature of the dose response for inorganic agents and will have an important impact on the estimated effects of such agents on environmental and human receptors...
  95. ncbi request reprint Estrogen and related compounds: biphasic dose responses
    E J Calabrese
    Department of Environmental Health Sciences, School of Public Health and Health Sciences, University of Massachusetts, Amherst 01003, USA
    Crit Rev Toxicol 31:503-15. 2001
    ..Mechanistic explanations of the biphasic responses are addressed...
  96. ncbi request reprint Apoptosis: biphasic dose responses
    E J Calabrese
    Department of Environmental Health Sciences, School of Public Health and Health Sciences, University of Massachusetts, Amherst 01003, USA
    Crit Rev Toxicol 31:607-13. 2001
    ..The underlying mechanisms and biomedical implications of this biphasic dose-response phenomenon are discussed...
  97. pmc Tumor resistance explained by hormesis
    Edward J Calabrese
    Department of Public Health, Environmental Health Sciences, University of Massachusetts, Amherst, MA 01003, USA
    Dose Response 8:80-2. 2010
    ....
  98. ncbi request reprint The future of hormesis: where do we go from here?
    E J Calabrese
    Department of Environmental Health Sciences, School of Public Health and Health Sciences, University of Massachusetts, Amherst 01003, USA
    Crit Rev Toxicol 31:637-48. 2001
    ..This perspective is then immediately critiqued by five authors in subsequent articles...
  99. ncbi request reprint The frequency of U-shaped dose responses in the toxicological literature
    E J Calabrese
    Department of Environmental Health Sciences, School of Public Health and Health Sciences, University of Massachusetts, Amherst, MA 01003, USA
    Toxicol Sci 62:330-8. 2001
    ..These findings have broad-based implications for study design, risk assessment methods, and the establishment of optimal drug doses and suggest important evolutionarily adaptive strategies for dose-response relationships...
  100. ncbi request reprint An allegation of scientific misconduct in the Bucci et al. article concerning the effects of DIMP on mink
    Edward J Calabrese
    Reprod Toxicol 19:443-6; author reply 447-51. 2005
  101. ncbi request reprint Toxicological diversity: making room for the U-shaped dose-response
    Edward J Calabrese
    Hum Exp Toxicol 22:465-6. 2003