Research Topics
| Zhengwei CaiSummaryAffiliation: University of Mississippi Medical Center Country: USA Publications
Research Grants
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Detail Information
Publications
Intrauterine hypoxia-ischemia alters expression of the NMDA receptor in the young rat brainZ Cai
Department of Pediatrics Newborn Medicine, University of Mississippi Medical Center, Jackson 39216, USA
Neurochem Res 26:487-95. 2001....- Disturbance of oligodendrocyte development, hypomyelination and white matter injury in the neonatal rat brain after intracerebral injection of lipopolysaccharideYi Pang
Department of Pediatrics, Division of Newborn Medicine, University of Mississippi Medical Center, 2500 N State Street, Jackson, MS 39216, USA
Brain Res Dev Brain Res 140:205-14. 2003..These results indicate that developing OLs may be the target cells for LPS-induced brain injury and inflammatory cytokines are possible mediators of LPS-induced brain injury... - Evaluation of the mechanism of vascular endothelial growth factor improvement of ischemic flap survival in ratsYi Pang
Department of Pediatrics, Division of Plasic Surgery, University of Mississippoi Medical Center, Jackson, 39216, USA
Plast Reconstr Surg 112:556-64. 2003..It was concluded that administration of exogenous VEGF could protect flaps from ischemia-reperfusion injury through the regulation of proinflammatory cytokines and the inhibition of cytotoxic nitric oxide production... - Minocycline alleviates hypoxic-ischemic injury to developing oligodendrocytes in the neonatal rat brainZ Cai
Department of Pediatrics, Division of Newborn Medicine, University of Mississippi Medical Center, Jackson, 39216 4505, USA
Neuroscience 137:425-35. 2006..The overall results suggest that reduction in microglial activation may protect developing oligodendrocytes in the neonatal brain from hypoxia-ischemia injury... - Role of interleukin-6 in lipopolysaccharide-induced brain injury and behavioral dysfunction in neonatal ratsY Pang
Department of Pediatrics, Division of Newborn Medicine, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS 39216, USA
Neuroscience 141:745-55. 2006..The present study indicates that the contribution to brain injury by interleukin-6 depends on its interaction with other lipopolysaccharide-induced agents and not on interleukin-6 alone... - Neuroprotective effects of N-acetylaspartylglutamate in a neonatal rat model of hypoxia-ischemiaZhengwei Cai
Department of Pediatrics, Division of Newborn Medicine, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS 39216 4505, USA
Eur J Pharmacol 437:139-45. 2002..The overall results suggest that the neuroprotective effect of NAAG is largely associated with activation of mGlu2/3 receptor... - Brain injury induced by intracerebral injection of interleukin-1beta and tumor necrosis factor-alpha in the neonatal ratZhengwei Cai
Department of Pediatrics, Division of Newborn Medicine, University of Mississippi Medical Center, Jackson, MS 39216, USA
Pediatr Res 56:377-84. 2004..The overall results indicate that IL-1beta may directly cause injuries to developing OLs and impair myelination in the neonatal rat brain and TNFalpha may have different roles in mediating brain injury... - Prenatal hypoxia-ischemia alters expression and activity of nitric oxide synthase in the young rat brain and causes learning deficitsZ Cai
Department of Pediatrics, University of Mississippi Medical Center, Jackson 39216 4505, USA
Brain Res Bull 49:359-65. 1999..The learning deficit in offspring is possibly associated with the reduction in expression of NOS mRNA and NOS activity in the hippocampus of these animals... - Intrauterine hypoxia-ischemia alters nitric oxide synthase expression and activity in fetal and neonatal rat brainsZ Cai
Department of Pediatrics, Division of Newborn Medicine, University of Mississippi Medical Center, 2500 N State Street, Jackson, MS 39216 4505, USA
Brain Res Dev Brain Res 109:265-9. 1998.... - Differential roles of tumor necrosis factor-alpha and interleukin-1 beta in lipopolysaccharide-induced brain injury in the neonatal ratZhengwei Cai
Department of Pediatrics, Division of Newborn Medicine, University of Mississippi Medical Center, Jackson, MS 39216, USA
Brain Res 975:37-47. 2003..These data suggest that IL-1beta may play an important role in mediating LPS-induced brain injury and TNFalpha may have complicated, probably dual, effects in LPS-induced brain injury... 
Interleukin-1beta-induced brain injury in the neonatal rat can be ameliorated by alpha-phenyl-n-tert-butyl-nitroneLir Wan Fan
Department of Pediatrics, Division of Newborn Medicine, University of Mississippi Medical Center, Jackson, MS 39216 4504, USA
Exp Neurol 220:143-53. 2009....- Suppression of glial activation is involved in the protection of IL-10 on maternal E. coli induced neonatal white matter injuryYi Pang
Department of Pediatrics, University of Mississippi Med. Ctr, Jackson, MS 39216-4505, USA
Brain Res Dev Brain Res 157:141-9. 2005..These results indicate that the protective effect of IL-10 against brain WMD is linked with suppression of microglial activation/macrophage infiltration, as shown by significantly reduced ED-1+ cells in the white matter... - Minocycline attenuates hypoxia-ischemia-induced neurological dysfunction and brain injury in the juvenile ratLir-Wan Fan
Department of Pediatrics, Division of Newborn Medicine, University of Mississippi Medical Center, Jackson, 39216, USA
Eur J Neurosci 24:341-50. 2006..The present results show that minocycline has long-lasting protective effects in the neonatal rat brain in terms of both hypoxia-ischemia-induced brain injury and the associated neurological dysfunction... - IGF-1 can either protect against or increase LPS-induced damage in the developing rat brainYi Pang
Department of Pediatrics, University of Mississippi Medical Center, Jackson, Mississippi 39216, USA
Pediatr Res 67:579-84. 2010..However, these adverse effects were not found in rats treated with IGF-1 alone. This study provides the alarming evidence that in an acute inflammatory condition, IGF-1 may have severe, harmful effects on the developing brain... - Hypoxia-ischemia induced neurological dysfunction and brain injury in the neonatal ratLir-Wan Fan
Department of Pediatrics, Division of Newborn Medicine, University of Mississippi Medical Center, Jackson, MS 39216, USA
Behav Brain Res 165:80-90. 2005..The present data also indicate that the degree of brain injury and the deficits of neurobehavioral performance in the rat are dependent on the hypoxic-ischemic condition, i.e., the exposure time to hypoxia... - alpha-Phenyl-n-tert-butyl-nitrone reduces lipopolysaccharide-induced white matter injury in the neonatal rat brainLir Wan Fan
Department of Pediatrics, University of Mississippi Medical Center, Jackson, Mississippi 39216, USA
Dev Neurobiol 68:365-78. 2008..The overall results suggest that antioxidant PBN, more than a straightforward free radical scavenger, may also involve anti-inflammatory and anti-apoptotic properties in protection of the neonatal rat brain from LPS-induced injury... - alpha-Phenyl-n-tert-butyl-nitrone attenuates lipopolysaccharide-induced brain injury and improves neurological reflexes and early sensorimotor behavioral performance in juvenile ratsLir Wan Fan
Department of Pediatrics, Division of Newborn Medicine, University of Mississippi Medical Center, Jackson, MS 39216 4505, USA
J Neurosci Res 86:3536-47. 2008.... - Neonatal exposure to lipopolysaccharide enhances vulnerability of nigrostriatal dopaminergic neurons to rotenone neurotoxicity in later lifeLir Wan Fan
Department of Pediatrics, Division of Newborn Medicine, University of Mississippi Medical Center, Jackson, MS 39216, USA
Neurobiol Dis 44:304-16. 2011..Our model may be useful for studying mechanisms involved in the pathogenesis of nonfamilial Parkinson's disease and the development of potential therapeutic treatments... 
Alpha-phenyl-n-tert-butyl-nitrone ameliorates hippocampal injury and improves learning and memory in juvenile rats following neonatal exposure to lipopolysaccharideLir Wan Fan
Department of Pediatrics, Division of Newborn Medicine, University of Mississippi Medical Center, Jackson, MS 39216, USA
Eur J Neurosci 27:1475-84. 2008..Treatment with PBN provided long-lasting protection against the LPS-induced axonal injury and neuronal loss, and improved the associated neurological dysfunctions in juvenile rats...- Minocycline reduces lipopolysaccharide-induced neurological dysfunction and brain injury in the neonatal ratLir-Wan Fan
Department of Pediatrics, Division of Newborn Medicine, University of Mississippi Medical Center, Jackson, Mississippi 39216-4504, USA
J Neurosci Res 82:71-82. 2005..These results suggest that inhibition of microglial activation by minocycline may have long-term protective effects in the neonatal brain on infection-induced brain injury and associated neurologic dysfunction in the rat... - Dopaminergic neuronal injury in the adult rat brain following neonatal exposure to lipopolysaccharide and the silent neurotoxicityLir Wan Fan
Department of Pediatrics, Division of Newborn Medicine, University of Mississippi Medical Center, Jackson, MS 39216 4504, USA
Brain Behav Immun 25:286-97. 2011..Our data further suggest that the compromised dendritic mitochondrial function might contribute, at least partially, to the silent neurotoxicity... - IGF-1 protects oligodendrocyte progenitor cells and improves neurological functions following cerebral hypoxia-ischemia in the neonatal ratShuying Lin
Department of Pediatrics, Division of Newborn Medicine, University of Mississippi Medical Center, Jackson, MS 39216, USA
Brain Res 1063:15-26. 2005..The neuroprotection of IGF-1 was associated with its antiapoptotic and mitogenic effects... - Intranasal administration of IGF-1 attenuates hypoxic-ischemic brain injury in neonatal ratsShuying Lin
Department of Pediatrics, Division of Newborn Medicine, University of Mississippi Medical Center, Jackson, MS 39216, USA
Exp Neurol 217:361-70. 2009..rhIGF-1 enhanced proliferation of neuronal and oligodendroglial progenitors after cerebral HI as well. These data suggest that iN administration of IGF-1 has the potential to be used for clinical treatment... - IGF-1 protects oligodendrocyte progenitors against TNFalpha-induced damage by activation of PI3K/Akt and interruption of the mitochondrial apoptotic pathwayYi Pang
Department of Pediatrics, Division of Newborn Medicine, University of Mississippi Medical Center, Jackson, Mississippi 39216, USA
Glia 55:1099-107. 2007..These observations indicate that the protection of OPCs by IGF-1 is mediated, at least partially, by interruption of the mitochondrial apoptotic pathway via activation of PI3K/Akt... - Neuroprotection of alpha-phenyl-n-tert-butyl-nitrone on the neonatal white matter is associated with anti-inflammationShuying Lin
Department of Pediatrics, Division of Newborn Medicine, University of Mississippi Medical Center, Jackson, MS 39216, United States
Neurosci Lett 405:52-6. 2006..The overall results indicate that besides free radical scavenging, anti-inflammation might partly contribute to the neuroprotection afforded by PBN on neonatal white matter following cerebral HI... - Dexamethasone and betamethasone protect against lipopolysaccharide-induced brain damage in neonatal ratsYi Pang
Department of Pediatrics, University of Mississippi Medical Center, Jackson, Mississippi, USA
Pediatr Res 71:552-8. 2012..The aim of this study was to test whether dexamethasone (Dex) and betamethasone (Beta), two of the most commonly used corticosteroids, protect against lipopolysaccharide (LPS)-induced white matter damage and neurobehavioral dysfunction... - alpha-Phenyl-n-tert-butyl-nitrone attenuates hypoxic-ischemic white matter injury in the neonatal rat brainShuying Lin
Department of Pediatrics, Division of Newborn Medicine, University of Mississippi Medical Center, Jackson, MS 39216, USA
Brain Res 1007:132-41. 2004..FR scavenging appears to be the primary mechanism underlying its neuroprotective effect... - Effect of tumor necrosis factor-alpha on developing optic nerve oligodendrocytes in cultureYi Pang
Department of Pediatrics, Division of Newborn Medicine, University of Mississippi Medical Center, Jackson, Mississippi 39216, USA
J Neurosci Res 80:226-34. 2005..Consistent with reports that progenitor cells are preferentially injured in PVL, our results may further support the role of TNF-alpha as a potential mediator of PVL... - Control of blood pressure, appetite, and glucose by leptin in mice lacking leptin receptors in proopiomelanocortin neuronsJussara M do Carmo
Department of Physiology and Biophysics, University of Mississippi Medical Center, 2500 North State St, Jackson, MS 39216, USA
Hypertension 57:918-26. 2011.... - Small intestinal submucosa in abdominal wall repair after TRAM flap harvesting in a rat modelFeng Zhang
Department of Pediatrics, Division of Plastic Surgery, University of Mississippi Medical Center, Jackson, 39216, USA
Plast Reconstr Surg 112:565-70. 2003..The use of small intestinal submucosa placement in combination with fascial repair can significantly improve the strength of the repaired abdominal wall after transverse rectus abdominis myocutaneous flap harvesting... - Lipopolysaccharide-activated microglia induce death of oligodendrocyte progenitor cells and impede their developmentY Pang
Department of Pediatrics, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS 39216, USA
Neuroscience 166:464-75. 2010..Our finding that LPS-activated microglia not only induce two waves of cell death but also greatly impair OL development may shed some light on the mechanisms underlying selective white matter damage and hypomyelination in PVL... - Minocycline attenuates lipopolysaccharide-induced white matter injury in the neonatal rat brainL-W Fan
Department of Pediatrics, Division of Newborn Medicine, University of Mississippi Medical Center, Jackson, MS 39216-4505, USA
Neuroscience 133:159-68. 2005.... - Interleukin-1beta-induced brain injury and neurobehavioral dysfunctions in juvenile rats can be attenuated by alpha-phenyl-n-tert-butyl-nitroneL W Fan
Department of Pediatrics, Division of Newborn Medicine, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS 39216, USA
Neuroscience 168:240-52. 2010.... - Acute, chronic and differential effects of several anesthetic barbiturates on glutamate receptor activation in neuronal cultureZ Cai
Department of Pharmacology and Toxicology, University of Mississippi Medical Center, Jackson 39216 4505
Brain Res 611:181-6. 1993..A similar hyperresponsiveness was not seen after the chronic treatment with phenobarbital.(ABSTRACT TRUNCATED AT 250 WORDS).. - Whole body hypothermia broadens the therapeutic window of intranasally administered IGF-1 in a neonatal rat model of cerebral hypoxia-ischemiaShuying Lin
Department of Pediatrics, Division of Newborn Medicine, University of Mississippi Medical Center, Jackson, MS 39216, USA
Brain Res 1385:246-56. 2011.... - Perinatal antidepressant exposure alters cortical network function in rodentsKimberly L Simpson
Department of Neurobiology and Anatomical Sciences, University of Mississippi Medical Center, Jackson, MS 39216, USA
Proc Natl Acad Sci U S A 108:18465-70. 2011..These findings indicate that 5-HT homeostasis is required for proper brain maturation and that fetal/infant exposure to SSRIs should be examined in humans, particularly those with developmental dysfunction, such as autism... - Chronic ischemia preferentially causes white matter injury in the neonatal rat brainZ Cai
Department of Pediatrics Newborn Medicine, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS 39216 4505
Brain Res 898:126-35. 2001..The overall results suggest that pre-oligodendrocytes and immature oligodendrocytes might be major targets for chronic ischemic insults and activated microglia/macrophages are possibly involved in the process of white matter injury... - Intrauterine hypoxia-ischemia reduces phosphoinositide hydrolysis stimulated by metabotropic glutamate receptor agonists in cultured rat cerebellar granule cellsP G Rhodes
Department of Pediatrics, University of Mississippi Medical Center, Jackson 39216 4505, USA
Brain Res Dev Brain Res 93:129-35. 1996.... - Prenatal ethanol exposure enhances glutamate release stimulated by quisqualate in rat cerebellar granule cell culturesP G Rhodes
Department of Pediatrics, University of Mississippi Medical Center, Jackson 39216 4505, USA
Mol Chem Neuropathol 33:99-111. 1998.... - Maternal infection-induced white matter injury is reduced by treatment with interleukin-10Sheryl Rodts-Palenik
Department of Obstetrics and Gynecology, University of Mississippi Medical Center, Jackson, MS, USA
Am J Obstet Gynecol 191:1387-92. 2004..CONCLUSION: These results suggest that maternal interleukin-10 therapy could provide neuroprotection for infants who are born to mothers with intrauterine infection... - Alpha-Phenyl-n-tert-butyl-nitrone attenuates lipopolysaccharide-induced neuronal injury in the neonatal rat brainL W Fan
Department of Pediatrics, Division of Newborn Medicine, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS 39216 4505, USA
Neuroscience 151:737-44. 2008..The protection of PBN may indicate the potential usefulness of antioxidants for treatment of these neuronal dysfunctions... - Developmental expression of endothelial nitric oxide synthase (eNOS) in the rat liverMichael J Nowicki
Division of Pediatric Gastroenterology, University of Mississippi Medical Center, Jackson, MS 39216, USA
Pediatr Res 54:732-8. 2003..eNOS expression and activity are developmentally regulated, increasing after birth coincident with an initial relative hypoxia and an increase in shear forces upon closure of the ductus venosus... - A quantitative histochemistry technique for measuring regional distribution of acetylcholinesterase in the brain using digital scanning densitometryT Ma
Department of Pharmacology and Toxicology, University of Mississippi Medical Center, Jackson, Mississippi 39216, USA
Anal Biochem 296:18-28. 2001..Because the digital scanning densitometers provide high quality and sensitive imaging, wide dynamic ranges, and convenient image analysis software, they are very useful tools in quantitative histochemistry... - Analysis of genes differentially expressed in astrocytes stimulated with lipopolysaccharide using cDNA arraysY Pang
Division of Newborn Medicine, Department of Pediatrics, University of Mississippi Medical Center, 2500 N State Street, Jackson, MS 39216, USA
Brain Res 914:15-22. 2001..These results indicate that both up-regulation of inflammatory cytokine expression and down-regulation of growth factor expression are probably involved in the response of astrocytes upon exposure to LPS... - Hepatotoxicity and lethality of halomethanes in Mongolian gerbils pretreated with chlordecone, phenobarbital or mirexZ Cai
Department of Pharmacology and Toxicology, University of Mississippi Medical Center, Jackson 39216 4505
Arch Toxicol 65:204-12. 1991..Evidence from histomorphometric studies was consistent with serum enzyme and 3H-T incorporation data.(ABSTRACT TRUNCATED AT 250 WORDS)..
Research Grants
- Perinatal hypoxia-ischemia, glutamate receptors, and Nitric Oxide SynthaseZhengwei Cai; Fiscal Year: 2007..Direct effects of inflammatory cytokines and IGF-1 on survival and differentiation of OLs will be examined in cultures of OLs at various maturation stages. ..
- Perinatal infection, cytokines and brain injuryZhengwei Cai; Fiscal Year: 2007....