Z Cai

Summary

Affiliation: University of Mississippi Medical Center
Country: USA

Publications

  1. doi request reprint The spatiotemporal pattern of somal and axonal pathology after perikaryal excitotoxic injury to retinal ganglion cells: a histological and morphometric study
    S K Saggu
    Department of Ophthalmology and Visual Sciences, The University of Adelaide, SA 5000, Australia
    Exp Neurol 211:52-8. 2008
  2. ncbi request reprint Chronic ischemia preferentially causes white matter injury in the neonatal rat brain
    Z Cai
    Department of Pediatrics Newborn Medicine, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS 39216 4505
    Brain Res 898:126-35. 2001
  3. pmc Interleukin-1beta-induced brain injury and neurobehavioral dysfunctions in juvenile rats can be attenuated by alpha-phenyl-n-tert-butyl-nitrone
    L W Fan
    Department of Pediatrics, Division of Newborn Medicine, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS 39216, USA
    Neuroscience 168:240-52. 2010
  4. doi request reprint Lipopolysaccharide-activated microglia induce death of oligodendrocyte progenitor cells and impede their development
    Y Pang
    Department of Pediatrics, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS 39216, USA
    Neuroscience 166:464-75. 2010
  5. ncbi request reprint Minocycline alleviates hypoxic-ischemic injury to developing oligodendrocytes in the neonatal rat brain
    Z Cai
    Department of Pediatrics, Division of Newborn Medicine, University of Mississippi Medical Center, Jackson, 39216 4505, USA
    Neuroscience 137:425-35. 2006
  6. ncbi request reprint Role of interleukin-6 in lipopolysaccharide-induced brain injury and behavioral dysfunction in neonatal rats
    Y Pang
    Department of Pediatrics, Division of Newborn Medicine, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS 39216, USA
    Neuroscience 141:745-55. 2006
  7. pmc Celecoxib attenuates systemic lipopolysaccharide-induced brain inflammation and white matter injury in the neonatal rats
    L W Fan
    Department of Pediatrics, Division of Newborn Medicine, University of Mississippi Medical Center, Jackson, MS 39216 4505, USA
    Neuroscience 240:27-38. 2013
  8. pmc Alpha-Phenyl-n-tert-butyl-nitrone attenuates lipopolysaccharide-induced neuronal injury in the neonatal rat brain
    L W Fan
    Department of Pediatrics, Division of Newborn Medicine, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS 39216 4505, USA
    Neuroscience 151:737-44. 2008
  9. pmc Intranasal administration of insulin-like growth factor-1 protects against lipopolysaccharide-induced injury in the developing rat brain
    Z Cai
    Department of Pediatrics, Division of Newborn Medicine, University of Mississippi Medical Center, Jackson, MS 39216, USA
    Neuroscience 194:195-207. 2011
  10. ncbi request reprint Analysis of genes differentially expressed in astrocytes stimulated with lipopolysaccharide using cDNA arrays
    Y Pang
    Division of Newborn Medicine, Department of Pediatrics, University of Mississippi Medical Center, 2500 N State Street, Jackson, MS 39216, USA
    Brain Res 914:15-22. 2001

Collaborators

Detail Information

Publications19

  1. doi request reprint The spatiotemporal pattern of somal and axonal pathology after perikaryal excitotoxic injury to retinal ganglion cells: a histological and morphometric study
    S K Saggu
    Department of Ophthalmology and Visual Sciences, The University of Adelaide, SA 5000, Australia
    Exp Neurol 211:52-8. 2008
    ..To describe the spatiotemporal pattern of somal and axonal pathologic changes after perikaryal excitotoxic injury to retinal ganglion cells in-vivo...
  2. ncbi request reprint Chronic ischemia preferentially causes white matter injury in the neonatal rat brain
    Z Cai
    Department of Pediatrics Newborn Medicine, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS 39216 4505
    Brain Res 898:126-35. 2001
    ..The overall results suggest that pre-oligodendrocytes and immature oligodendrocytes might be major targets for chronic ischemic insults and activated microglia/macrophages are possibly involved in the process of white matter injury...
  3. pmc Interleukin-1beta-induced brain injury and neurobehavioral dysfunctions in juvenile rats can be attenuated by alpha-phenyl-n-tert-butyl-nitrone
    L W Fan
    Department of Pediatrics, Division of Newborn Medicine, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS 39216, USA
    Neuroscience 168:240-52. 2010
    ....
  4. doi request reprint Lipopolysaccharide-activated microglia induce death of oligodendrocyte progenitor cells and impede their development
    Y Pang
    Department of Pediatrics, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS 39216, USA
    Neuroscience 166:464-75. 2010
    ..Our finding that LPS-activated microglia not only induce two waves of cell death but also greatly impair OL development may shed some light on the mechanisms underlying selective white matter damage and hypomyelination in PVL...
  5. ncbi request reprint Minocycline alleviates hypoxic-ischemic injury to developing oligodendrocytes in the neonatal rat brain
    Z Cai
    Department of Pediatrics, Division of Newborn Medicine, University of Mississippi Medical Center, Jackson, 39216 4505, USA
    Neuroscience 137:425-35. 2006
    ..The overall results suggest that reduction in microglial activation may protect developing oligodendrocytes in the neonatal brain from hypoxia-ischemia injury...
  6. ncbi request reprint Role of interleukin-6 in lipopolysaccharide-induced brain injury and behavioral dysfunction in neonatal rats
    Y Pang
    Department of Pediatrics, Division of Newborn Medicine, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS 39216, USA
    Neuroscience 141:745-55. 2006
    ..The present study indicates that the contribution to brain injury by interleukin-6 depends on its interaction with other lipopolysaccharide-induced agents and not on interleukin-6 alone...
  7. pmc Celecoxib attenuates systemic lipopolysaccharide-induced brain inflammation and white matter injury in the neonatal rats
    L W Fan
    Department of Pediatrics, Division of Newborn Medicine, University of Mississippi Medical Center, Jackson, MS 39216 4505, USA
    Neuroscience 240:27-38. 2013
    ..The overall results suggest that celecoxib was capable of attenuating the brain injury and neurobehavioral disturbance induced by systemic LPS exposure, and the protective effects are associated with its anti-inflammatory properties...
  8. pmc Alpha-Phenyl-n-tert-butyl-nitrone attenuates lipopolysaccharide-induced neuronal injury in the neonatal rat brain
    L W Fan
    Department of Pediatrics, Division of Newborn Medicine, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS 39216 4505, USA
    Neuroscience 151:737-44. 2008
    ..The protection of PBN may indicate the potential usefulness of antioxidants for treatment of these neuronal dysfunctions...
  9. pmc Intranasal administration of insulin-like growth factor-1 protects against lipopolysaccharide-induced injury in the developing rat brain
    Z Cai
    Department of Pediatrics, Division of Newborn Medicine, University of Mississippi Medical Center, Jackson, MS 39216, USA
    Neuroscience 194:195-207. 2011
    ..This is an indication that direct anti-inflammation might not be the primary mechanism for the protection of IGF-1, and other mechanisms, such as anti-apoptotic effects, are likely involved in its protective effects...
  10. ncbi request reprint Analysis of genes differentially expressed in astrocytes stimulated with lipopolysaccharide using cDNA arrays
    Y Pang
    Division of Newborn Medicine, Department of Pediatrics, University of Mississippi Medical Center, 2500 N State Street, Jackson, MS 39216, USA
    Brain Res 914:15-22. 2001
    ..These results indicate that both up-regulation of inflammatory cytokine expression and down-regulation of growth factor expression are probably involved in the response of astrocytes upon exposure to LPS...
  11. ncbi request reprint Minocycline attenuates lipopolysaccharide-induced white matter injury in the neonatal rat brain
    L W Fan
    Department of Pediatrics, Division of Newborn Medicine, University of Mississippi Medical Center, Jackson, MS 39216 4505, USA
    Neuroscience 133:159-68. 2005
    ....
  12. ncbi request reprint Intrauterine hypoxia-ischemia alters expression of the NMDA receptor in the young rat brain
    Z Cai
    Department of Pediatrics Newborn Medicine, University of Mississippi Medical Center, Jackson 39216, USA
    Neurochem Res 26:487-95. 2001
    ....
  13. ncbi request reprint Intrauterine hypoxia-ischemia alters nitric oxide synthase expression and activity in fetal and neonatal rat brains
    Z Cai
    Department of Pediatrics, Division of Newborn Medicine, University of Mississippi Medical Center, 2500 N State Street, Jackson, MS 39216 4505, USA
    Brain Res Dev Brain Res 109:265-9. 1998
    ....
  14. ncbi request reprint A quantitative histochemistry technique for measuring regional distribution of acetylcholinesterase in the brain using digital scanning densitometry
    T Ma
    Department of Pharmacology and Toxicology, University of Mississippi Medical Center, Jackson, Mississippi 39216, USA
    Anal Biochem 296:18-28. 2001
    ..Because the digital scanning densitometers provide high quality and sensitive imaging, wide dynamic ranges, and convenient image analysis software, they are very useful tools in quantitative histochemistry...
  15. ncbi request reprint Effect of tunicamycin on peripheral nerves in the guinea pig
    Z Cai
    Neuropathology Laboratory, Institute of Medical and Veterinary Science, PO Box 14 Rundle Mall, Adelaide, South Australia 5000
    Aust Vet J 82:308. 2004
  16. ncbi request reprint Early paranodal myelin swellings (tomacula) in an avian riboflavin deficiency model of demyelinating neuropathy
    Z Cai
    Hanson Institute Centre for Neurological Diseases, Institute of Medical and Veterinary Science, Adelaide, Australia
    Exp Neurol 198:65-71. 2006
    ..In support of this notion was the finding of focal paranodal myelin swellings (tomacula) due to redundant folding of myelin sheaths, early in the time course of an avian riboflavin deficiency model of demyelinating neuropathy...
  17. ncbi request reprint Accuracy of sampling methods in morphometric studies of human sural nerves
    Z Cai
    Department of Neurology and University Department of Neurology, Royal Adelaide Hospital, Adelaide, South Australia
    J Clin Neurosci 9:181-6. 2002
    ..For accurate morphometric data it is necessary to quantitate all the myelinated fibres in the sural nerve...
  18. ncbi request reprint A novel method for correlating internal and external structure of individual myelinated nerve fibres
    Z Cai
    Department of Neurology and University Department of Neurology, Royal Adelaide Hospital, Adelaide, Australia
    J Neurosci Methods 105:39-43. 2001
    ..This method is particularly useful for the correlative study of the myelin-axon relationships...
  19. ncbi request reprint Haploinsufficiency of AML1 affects the temporal and spatial generation of hematopoietic stem cells in the mouse embryo
    Z Cai
    Department of Pathology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Immunity 13:423-31. 2000
    ..Moreover, haploinsufficiency results in a dramatic change in the temporal and spatial distribution of HSCs, leading to their early appearance in the normal position in the aorta-gonad-mesonephros region and also in the yolk sac...