Weibo Cai

Summary

Affiliation: University of Wisconsin
Country: USA

Publications

  1. doi request reprint Multimodality molecular imaging of tumor angiogenesis
    Weibo Cai
    Department of Radiology and Medical Physics, School of Medicine and Public Health, University of Wisconsin Madison, Madison, Wisconsin 53792 3252, USA
    J Nucl Med 49:113S-28S. 2008
  2. ncbi request reprint Imaging of integrins as biomarkers for tumor angiogenesis
    Weibo Cai
    The Molecular Imaging Program at Stanford, Department of Radiology and Bio X Program, Stanford University School of Medicine, California, USA
    Curr Pharm Des 14:2943-73. 2008
  3. ncbi request reprint Intraoperative targeted optical imaging: a guide towards tumor-free margins in cancer surgery
    Hakan Orbay
    Departments of Radiology and Medical Physics, School of Medicine and Public Health, University of Wisconsin Madison, Room 7137, 1111 Highland Ave, Madison, WI 53705 2275, USA
    Curr Pharm Biotechnol 14:733-42. 2014
  4. pmc Multimodality imaging of CXCR4 in cancer: current status towards clinical translation
    T R Nayak
    Departments of Radiology and Medical Physics, University of Wisconsin Madison, Room 7137, 1111 Highland Avenue, Madison, WI 53705 2275, USA
    Curr Mol Med 13:1538-48. 2013
  5. pmc Quantum dot-based nanoprobes for in vivo targeted imaging
    Y Zhu
    W Cai Departments of Radiology and Medical Physics, University of Wisconsin Madison, Room 7137, 1111 Highland Avenue, Madison, WI 53705 2275, USA
    Curr Mol Med 13:1549-67. 2013
  6. pmc Biomedical applications of zinc oxide nanomaterials
    Y Zhang
    Departments of Radiology and Medical Physics, University of Wisconsin Madison, 1111 Highland Ave, Room 7137, Madison, WI 53705 2275, USA
    Curr Mol Med 13:1633-45. 2013
  7. pmc Multimodality imaging of RNA interference
    T R Nayak
    Department of Radiology, University of Wisconsin Madison, Madison, WI 53705 2275, USA
    Curr Med Chem 20:3664-75. 2013
  8. pmc Molecular imaging strategies for in vivo tracking of micrornas: a comprehensive review
    R Hernandez
    Department of Medical Physics, University of Wisconsin Madison, WI 53705 2275, USA
    Curr Med Chem 20:3594-603. 2013
  9. ncbi request reprint Editorial: PET tracers based on nonstandard radionuclides
    Weibo Cai
    Curr Radiopharm 4:75. 2011
  10. pmc Molecular imaging with nucleic acid aptamers
    H Hong
    Department of Radiology, University of Wisconsin Madison, 1111 Highland Ave, Madison, WI 53705 2275, USA
    Curr Med Chem 18:4195-205. 2011

Collaborators

Detail Information

Publications85

  1. doi request reprint Multimodality molecular imaging of tumor angiogenesis
    Weibo Cai
    Department of Radiology and Medical Physics, School of Medicine and Public Health, University of Wisconsin Madison, Madison, Wisconsin 53792 3252, USA
    J Nucl Med 49:113S-28S. 2008
    ..Not limited to cancer, these novel agents can also have broad applications for many other angiogenesis-related diseases...
  2. ncbi request reprint Imaging of integrins as biomarkers for tumor angiogenesis
    Weibo Cai
    The Molecular Imaging Program at Stanford, Department of Radiology and Bio X Program, Stanford University School of Medicine, California, USA
    Curr Pharm Des 14:2943-73. 2008
    ..In the new era of personalized medicine, fast clinical translation and incorporation of integrin imaging into anti-cancer clinical trials will be critical for the maximum benefit of cancer patients...
  3. ncbi request reprint Intraoperative targeted optical imaging: a guide towards tumor-free margins in cancer surgery
    Hakan Orbay
    Departments of Radiology and Medical Physics, School of Medicine and Public Health, University of Wisconsin Madison, Room 7137, 1111 Highland Ave, Madison, WI 53705 2275, USA
    Curr Pharm Biotechnol 14:733-42. 2014
    ....
  4. pmc Multimodality imaging of CXCR4 in cancer: current status towards clinical translation
    T R Nayak
    Departments of Radiology and Medical Physics, University of Wisconsin Madison, Room 7137, 1111 Highland Avenue, Madison, WI 53705 2275, USA
    Curr Mol Med 13:1538-48. 2013
    ..Since CXCR4 is also involved in many other diseases beyond cancer, these clinically translatable probes can also play multiple roles in other pathological disorders such as myocardial infarction and several immunodeficiency disorders. ..
  5. pmc Quantum dot-based nanoprobes for in vivo targeted imaging
    Y Zhu
    W Cai Departments of Radiology and Medical Physics, University of Wisconsin Madison, Room 7137, 1111 Highland Avenue, Madison, WI 53705 2275, USA
    Curr Mol Med 13:1549-67. 2013
    ..In addition, QD-based multifunctional nanoprobes are also summarized. ..
  6. pmc Biomedical applications of zinc oxide nanomaterials
    Y Zhang
    Departments of Radiology and Medical Physics, University of Wisconsin Madison, 1111 Highland Ave, Room 7137, Madison, WI 53705 2275, USA
    Curr Mol Med 13:1633-45. 2013
    ....
  7. pmc Multimodality imaging of RNA interference
    T R Nayak
    Department of Radiology, University of Wisconsin Madison, Madison, WI 53705 2275, USA
    Curr Med Chem 20:3664-75. 2013
    ....
  8. pmc Molecular imaging strategies for in vivo tracking of micrornas: a comprehensive review
    R Hernandez
    Department of Medical Physics, University of Wisconsin Madison, WI 53705 2275, USA
    Curr Med Chem 20:3594-603. 2013
    ..Non-invasive imaging of miRNA is an invaluable method that can not only significantly advance our understandings of a wide range of human diseases, but also lead to new and more effective treatment strategies for these diseases. ..
  9. ncbi request reprint Editorial: PET tracers based on nonstandard radionuclides
    Weibo Cai
    Curr Radiopharm 4:75. 2011
  10. pmc Molecular imaging with nucleic acid aptamers
    H Hong
    Department of Radiology, University of Wisconsin Madison, 1111 Highland Ave, Madison, WI 53705 2275, USA
    Curr Med Chem 18:4195-205. 2011
    ....
  11. pmc Tumor-targeted drug delivery with aptamers
    Y Zhang
    Department of Medical Physics, School of Medicine and Public Health, University of Wisconsin Madison, Madison, Wisconsin 53705 2275, USA
    Curr Med Chem 18:4185-94. 2011
    ..Therefore, future directions and challenges in aptamer-based drug delivery are also discussed...
  12. ncbi request reprint Dual-function probe for PET and near-infrared fluorescence imaging of tumor vasculature
    Weibo Cai
    Molecular Imaging Program at Stanford MIPS, Department of Radiology, and Bio X Program, Stanford University School of Medicine, Stanford, CA 94305 5484, USA
    J Nucl Med 48:1862-70. 2007
    ..The development of a dual-function PET/near-infrared fluorescence (NIRF) probe can allow for accurate assessment of the pharmacokinetics and tumor-targeting efficacy of QDs...
  13. doi request reprint The temporal correlation of dynamic contrast-enhanced magnetic resonance imaging with tumor angiogenesis in a murine glioblastoma model
    Anand Veeravagu
    Department of Neurosurgery, Stanford University School of Medicine, 1201 Welch Road, Stanford, CA 94305, USA
    Neurol Res 30:952-9. 2008
    ..The purpose of this study was to characterize changes in tumor vascular permeability, vascular density and vessel morphology in vivo during angiogenesis...
  14. pmc Imaging tumor angiogenesis in breast cancer experimental lung metastasis with positron emission tomography, near-infrared fluorescence, and bioluminescence
    Yin Zhang
    Department of Medical Physics, University of Wisconsin Madison, Room 7137, 1111 Highland Avenue, Madison, WI 53705, USA
    Angiogenesis 16:663-74. 2013
    ....
  15. ncbi request reprint (64)Cu-labeled tetrameric and octameric RGD peptides for small-animal PET of tumor alpha(v)beta(3) integrin expression
    Zi Bo Li
    Molecular Imaging Program at Stanford, Department of Radiology and Bio X Program, Stanford University School of Medicine, Stanford, California 94305, USA
    J Nucl Med 48:1162-71. 2007
    ..In this study, we developed (64)Cu-labeled multimeric RGD peptides, E{E[c(RGDyK)](2)}(2) (RGD tetramer) and E(E{E[c(RGDyK)](2)}(2))(2) (RGD octamer), for PET imaging of tumor integrin alpha(v)beta(3) expression...
  16. ncbi request reprint microPET of tumor integrin alphavbeta3 expression using 18F-labeled PEGylated tetrameric RGD peptide (18F-FPRGD4)
    Zhanhong Wu
    The Molecular Imaging Program at Stanford MIPS, Department of Radiology and Bio X Program, Stanford University School of Medicine, 1201 Welch Road, Stanford, CA 94305, USA
    J Nucl Med 48:1536-44. 2007
    ..Here we report an example of (18)F-labeled tetrameric RGD peptide for PET of alpha(v)beta(3) expression in both xenograft and spontaneous tumor models...
  17. ncbi request reprint Quantitative radioimmunoPET imaging of EphA2 in tumor-bearing mice
    Weibo Cai
    Department of Radiology and Bio X Program, The Molecular Imaging Program at Stanford, Stanford University School of Medicine, 1201 Welch Road, Stanford, CA 94305 5484, USA
    Eur J Nucl Med Mol Imaging 34:2024-36. 2007
    ..Although many recent reports have focused on blocking the EphA2 signaling pathway in cancer, the in vivo imaging of EphA2 has not yet been investigated...
  18. doi request reprint Integrin-targeted imaging and therapy with RGD4C-TNF fusion protein
    Hui Wang
    Molecular Imaging Program at Stanford, Department of Radiology and Bio X Program, Stanford University School of Medicine, 1201 Welch Road, P095, Stanford, CA 94305 5484, USA
    Mol Cancer Ther 7:1044-53. 2008
    ..Ex vivo tissue staining confirmed specific cytotoxicity of RGD4C-TNF against integrin-positive tumor cells and tumor vasculature...
  19. doi request reprint Dual-modality optical and positron emission tomography imaging of vascular endothelial growth factor receptor on tumor vasculature using quantum dots
    Kai Chen
    Department of Radiology and Bio X Program, School of Medicine, Stanford University, Stanford, CA 94305 5484, USA
    Eur J Nucl Med Mol Imaging 35:2235-44. 2008
    ..The development of a dual-function positron emission tomography (PET)/near-infrared fluorescence (NIRF) probe might allow the accurate assessment of the tumor-targeting efficacy of QDs...
  20. doi request reprint Quantitative PET imaging of VEGF receptor expression
    Kai Chen
    Department of Radiology and Bio X Program, Stanford University School of Medicine, CA 94305 5484, USA
    Mol Imaging Biol 11:15-22. 2009
    ..Quantitative positron emission tomography (PET) imaging of VEGFR will facilitate the planning of whether, and when, to start anti-angiogenic treatment and enable more robust and effective monitoring of such treatment...
  21. ncbi request reprint PET of vascular endothelial growth factor receptor expression
    Weibo Cai
    Molecular Imaging Program at Stanford MIPS, Department of Radiology and Bio X Program, Stanford University School of Medicine, Stanford, CA 94305 5484, USA
    J Nucl Med 47:2048-56. 2006
    ..Here we report the first example, to our knowledge, of (64)Cu-labeled vascular endothelial growth factor 121 (VEGF(121)) for PET of VEGF receptor (VEGFR) expression in vivo...
  22. ncbi request reprint In vitro and in vivo characterization of 64Cu-labeled Abegrin, a humanized monoclonal antibody against integrin alpha v beta 3
    Weibo Cai
    The Molecular Imaging Program at Stanford, Department of Radiology and Bio X Program, Stanford University School of Medicine, Stanford, CA 94305 5484, USA
    Cancer Res 66:9673-81. 2006
    ..Chemotherapeutics or radiotherapeutics using Abegrin as the delivering vehicle may also be effective in treating integrin alpha(v)beta(3)-positive tumors...
  23. doi request reprint Integrin alphavbeta3-targeted radioimmunotherapy of glioblastoma multiforme
    Anand Veeravagu
    Molecular Imaging Program at Stanford, Department of Radiology and Bio X Program, Stanford University School of Medicine, Stanford, California 94305 5484, USA
    Clin Cancer Res 14:7330-9. 2008
    ..The purpose of this study was to evaluate the efficacy of a novel 90Y-Abegrin radioimmunotherapeutic agent in murine xenograft glioblastoma models with noninvasive in vivo molecular imaging modalities...
  24. ncbi request reprint A new PET tracer specific for vascular endothelial growth factor receptor 2
    Hui Wang
    The Molecular Imaging Program at Stanford, Department of Radiology and Bio X Program, Stanford University School of Medicine, 1201 Welch Road, Stanford, CA 94305 5484, USA
    Eur J Nucl Med Mol Imaging 34:2001-10. 2007
    ..The aim of this study was to develop a VEGFR-2-specific PET tracer...
  25. ncbi request reprint PET imaging of acute and chronic inflammation in living mice
    Qizhen Cao
    The Molecular Imaging Program at Stanford, Department of Radiology and Bio X Program, Stanford University School of Medicine, Stanford, CA 94305 5484, USA
    Eur J Nucl Med Mol Imaging 34:1832-42. 2007
    ..In this study, we evaluated the 12-O-tetradecanoyl-phorbol-13-acetate (TPA)-induced acute and chronic inflammation in living mice by PET imaging of TNF-alpha and integrin alpha(v)beta(3) expression...
  26. ncbi request reprint 18F-labeled mini-PEG spacered RGD dimer (18F-FPRGD2): synthesis and microPET imaging of alphavbeta3 integrin expression
    Zhanhong Wu
    The Molecular Imaging Program at Stanford, Department of Radiology and Bio X Program, Stanford University School of Medicine, Stanford, CA 94305 5484, USA
    Eur J Nucl Med Mol Imaging 34:1823-31. 2007
    ..The goal of this study was to improve the radiolabeling yield, without compromising the tumor targeting efficiency and in vivo kinetics, by incorporating a hydrophilic bifunctional mini-PEG spacer...
  27. ncbi request reprint Non-invasive PET imaging of EGFR degradation induced by a heat shock protein 90 inhibitor
    Gang Niu
    The Molecular Imaging Program at Stanford, Department of Radiology and Bio X Program, Stanford University School of Medicine, 1201 Welch Rd, P095, Stanford, CA 94305 5484, USA
    Mol Imaging Biol 10:99-106. 2008
    ..The aim of this study is to non-invasively monitor the epidermal growth factor receptor (EGFR) response to a Hsp90 inhibitor-17-AAG treatment in a PC-3 prostate cancer model...
  28. ncbi request reprint PET imaging of colorectal cancer in xenograft-bearing mice by use of an 18F-labeled T84.66 anti-carcinoembryonic antigen diabody
    Weibo Cai
    Molecular Imaging Program at Stanford, Department of Radiology, Stanford University School of Medicine, Stanford, California 94305 5484, USA
    J Nucl Med 48:304-10. 2007
    ..66 diabody, a genetically engineered noncovalent dimer of single-chain variable fragments, for small-animal PET imaging of CEA expression in xenograft-bearing mice...
  29. pmc Positron emission tomography imaging of CD105 expression with a 64Cu-labeled monoclonal antibody: NOTA is superior to DOTA
    Yin Zhang
    Department of Medical Physics, University of Wisconsin Madison, Madison, Wisconsin, United States of America
    PLoS ONE 6:e28005. 2011
    ..In conclusion, this study confirmed that NOTA is a superior chelator to DOTA for PET imaging with (64)Cu-labeled TRC105...
  30. pmc PET imaging of CD105/endoglin expression with a ⁶¹/⁶⁴Cu-labeled Fab antibody fragment
    Yin Zhang
    Department of Medical Physics, University of Wisconsin Madison, 1111 Highland Avenue, Madison, WI 53705 2275, USA
    Eur J Nucl Med Mol Imaging 40:759-67. 2013
    ..e., endoglin), and investigate its potential for PET imaging of tumor angiogenesis in a small-animal model after (61/64)Cu labeling...
  31. pmc Radiolabeled γ-AApeptides: a new class of tracers for positron emission tomography
    Yunan Yang
    Department of Radiology, University of Wisconsin Madison, WI 53705, USA
    Chem Commun (Camb) 48:7850-2. 2012
    ....
  32. pmc In vivo targeting and imaging of tumor vasculature with radiolabeled, antibody-conjugated nanographene
    Hao Hong
    Department of Radiology, University of Wisconsin Madison, Madison, Wisconsin 53706, USA
    ACS Nano 6:2361-70. 2012
    ..Since poor extravasation is a major hurdle for nanomaterial-based tumor targeting in vivo, this study also establishes CD105 as a promising vascular target for future cancer nanomedicine...
  33. doi request reprint Multimodality imaging of IL-18--binding protein-Fc therapy of experimental lung metastasis
    Qizhen Cao
    The Molecular Imaging Program at Stanford, Department of Radiology and Bio X Program, Stanford University School of Medicine, 1201 Welch Road, Stanford, CA 94305, USA
    Clin Cancer Res 14:6137-45. 2008
    ....
  34. ncbi request reprint Quantitative PET of EGFR expression in xenograft-bearing mice using 64Cu-labeled cetuximab, a chimeric anti-EGFR monoclonal antibody
    Weibo Cai
    The Molecular Imaging Program at Stanford MIPS, Department of Radiology and Bio X Program, Stanford University School of Medicine, 1201 Welch Rd P095, Stanford, CA 94305 5484, USA
    Eur J Nucl Med Mol Imaging 34:850-8. 2007
    ..Here we report for the first time the quantitative positron emission tomography (PET) imaging of EGFR expression in xenograft-bearing mice using 64Cu-labeled cetuximab...
  35. ncbi request reprint Vascular endothelial growth factor and vascular endothelial growth factor receptor inhibitors as anti-angiogenic agents in cancer therapy
    Anand Veeravagu
    Department of Neurosurgery, Stanford University School of Medicine, Stanford, CA 94305 5484, USA
    Recent Pat Anticancer Drug Discov 2:59-71. 2007
    ..This review will focus on patents which target VEGF-[A-F] and/or VEGFR-[1-3] for use in anti-cancer treatment...
  36. pmc Positron emission tomography imaging of tumor angiogenesis with a (61/64)Cu-labeled F(ab')(2) antibody fragment
    Hao Hong
    Department of Radiology, University of Wisconsin Madison, Madison, WI 53705 2275, United States
    Mol Pharm 10:709-16. 2013
    ....
  37. pmc Tumor vasculature targeting and imaging in living mice with reduced graphene oxide
    Sixiang Shi
    Materials Science Program, University of Wisconsin Madison, Madison, WI 53705 2275, USA
    Biomaterials 34:3002-9. 2013
    ..Since RGO exhibits desirable properties for photothermal therapy, the tumor-specific RGO conjugate developed in this work may serve as a promising theranostic agent that integrates imaging and therapeutic components...
  38. pmc Positron emission tomography imaging of CD105 expression with 89Zr-Df-TRC105
    Hao Hong
    Department of Radiology, University of Wisconsin Madison, Madison, WI 53705, USA
    Eur J Nucl Med Mol Imaging 39:138-48. 2012
    ..The goal of this study was to develop an (89)Zr-based PET tracer for noninvasive imaging of CD105 expression...
  39. pmc A thiol-reactive 18F-labeling agent, N-[2-(4-18F-fluorobenzamido)ethyl]maleimide, and synthesis of RGD peptide-based tracer for PET imaging of alpha v beta 3 integrin expression
    Weibo Cai
    Molecular Imaging Program at Stanford MIPS and Bio X Program, Department of Radiology, Stanford University School of Medicine, Stanford, California 94305 5484, USA
    J Nucl Med 47:1172-80. 2006
    ..In this study we introduced a new method of labeling RGD peptides through a thiol-reactive synthon, N-[2-(4-18F-fluorobenzamido)ethyl]maleimide (18F-FBEM)...
  40. ncbi request reprint Combination of integrin siRNA and irradiation for breast cancer therapy
    Qizhen Cao
    Molecular Imaging Program at Stanford and Bio X, Department of Radiology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Biochem Biophys Res Commun 351:726-32. 2006
    ..This study, with further optimization, may provide a simple and highly efficient treatment strategy for breast cancer as well as other integrin alpha(v)beta(3)-positive cancer types...
  41. doi request reprint Positron emission tomography imaging of poststroke angiogenesis
    Weibo Cai
    The Molecular Imaging Program at Stanford, Department of Radiology, Stanford University, Stanford, CA, USA
    Stroke 40:270-7. 2009
    ..In this study, we imaged VEGFR expression with positron emission tomography (PET) to noninvasively analyze poststroke angiogenesis...
  42. doi request reprint Multimodality Imaging of Breast Cancer Experimental Lung Metastasis with Bioluminescence and a Monoclonal Antibody Dual-Labeled with (89)Zr and IRDye 800CW
    Hao Hong
    Department of Radiology, University of Wisconsin Madison, Madison, Wisconsin 53705, United States
    Mol Pharm 9:2339-49. 2012
    ..Broad clinical potential of TRC105-based agents was shown in many tumor types, which also enabled early detection of small metastasis and intraoperative guidance for tumor removal. ..
  43. pmc Immuno-PET of tissue factor in pancreatic cancer
    Hao Hong
    Department of Radiology, University of Wisconsin, Madison, WI, USA
    J Nucl Med 53:1748-54. 2012
    ..Upregulation of tissue factor (TF) expression leads to increased patient morbidity and mortality in many solid tumor types. The goal of this study was to develop a PET tracer for imaging of TF expression in pancreatic cancer...
  44. doi request reprint Monitoring of the biological response to murine hindlimb ischemia with 64Cu-labeled vascular endothelial growth factor-121 positron emission tomography
    Jurgen K Willmann
    Department of Radiology and Bio X Program, Stanford University School of Medicine, Stanford, Calif, USA
    Circulation 117:915-22. 2008
    ....
  45. ncbi request reprint In vivo bioluminescence tumor imaging of RGD peptide-modified adenoviral vector encoding firefly luciferase reporter gene
    Gang Niu
    Department of Radiation Oncology, Stanford University School of Medicine, Stanford, CA, USA
    Mol Imaging Biol 9:126-34. 2007
    ..The goal of this study is to demonstrate the feasibility of chemically modified human adenovirus (Ad) vectors for tumor retargeting...
  46. pmc In vivo imaging of RNA interference
    Hao Hong
    Departments of Radiology and Medical Physics and University of Wisconsin Carbone Cancer Center, University of Wisconsin Madison, Madison, Wisconsin 53705, USA
    J Nucl Med 51:169-72. 2010
    ..Incorporation of suitable molecular imaging techniques into future RNAi-based clinical trials will provide more pieces of the puzzle, thus facilitating the transformation of RNAi into a powerful therapeutic modality in the clinic...
  47. pmc Gold Nanorods Conjugated with Doxorubicin and cRGD for Combined Anticancer Drug Delivery and PET Imaging
    Yuling Xiao
    1 Department of Biomedical Engineering and Wisconsin Institutes for Discovery, University of Wisconsin Madison, Madison, WI 53706, USA
    Theranostics 2:757-68. 2012
    ....
  48. ncbi request reprint Multimodality molecular imaging of glioblastoma growth inhibition with vasculature-targeting fusion toxin VEGF121/rGel
    Andrew R Hsu
    The Molecular Imaging Program at Stanford, Department of Radiology and Bio X Program, Stanford University School of Medicine, Stanford, California 94305 5484, USA
    J Nucl Med 48:445-54. 2007
    ....
  49. pmc Cancer-targeted optical imaging with fluorescent zinc oxide nanowires
    Hao Hong
    Department of Radiology and Medical Physics, University of Wisconsin Madison, Madison, Wisconsin 53705, United States
    Nano Lett 11:3744-50. 2011
    ....
  50. doi request reprint Preparation of peptide-conjugated quantum dots for tumor vasculature-targeted imaging
    Weibo Cai
    Molecular Imaging Program at Stanford MIPS, Department of Radiology and Bio X Program, Stanford University School of Medicine, Stanford, California 94305, USA
    Nat Protoc 3:89-96. 2008
    ..In general, QD conjugation and in vitro validation of the peptide-conjugated QDs can be accomplished within 1-2 d; in vivo imaging will take another 1-2 d depending on the experimental design...
  51. ncbi request reprint Integrin alpha v beta 3 antagonists for anti-angiogenic cancer treatment
    Andrew R Hsu
    Department of Neurosurgery, Stanford University School of Medicine, Stanford, CA 94305, USA
    Recent Pat Anticancer Drug Discov 2:143-58. 2007
    ..This review will focus on the key points and distinguishing factors for patents which use antibodies, RGD peptides, non-RGD peptides, peptidomimetics, and amine salts as alpha(v)beta(3) antagonists...
  52. pmc Graphene: a versatile nanoplatform for biomedical applications
    Yin Zhang
    Department of Medical Physics, University of Wisconsin Madison, WI, USA
    Nanoscale 4:3833-42. 2012
    ..The future of graphene-based nanomaterials in biomedicine looks brighter than ever, and it is expected that they will find a wide range of biomedical applications with future research effort and interdisciplinary collaboration...
  53. pmc In vivo targeting and positron emission tomography imaging of tumor vasculature with (66)Ga-labeled nano-graphene
    Hao Hong
    Department of Radiology, University of Wisconsin Madison, Madison, WI 53705 2275, USA
    Biomaterials 33:4147-56. 2012
    ..Successful demonstration of in vivo tumor targeting with GO, along with the versatile chemistry of graphene-based nanomaterials, makes them suitable nanoplatforms for future biomedical research such as cancer theranostics...
  54. pmc Positron emission tomography imaging of tumor angiogenesis with a 66Ga-labeled monoclonal antibody
    Jonathan W Engle
    Department of Medical Physics, University of Wisconsin Madison, Wisconsin, United States
    Mol Pharm 9:1441-8. 2012
    ..Successful PET imaging with high specific activity (66)Ga (>700 GBq/μmol has been achieved) as the radiolabel opens many new possibilities for future PET research with antibodies or other targeting ligands...
  55. ncbi request reprint How molecular imaging is speeding up antiangiogenic drug development
    Weibo Cai
    The Molecular Imaging Program at Stanford, Department of Radiology and Bio X Program, Stanford University School of Medicine, 1201 Welch Road, P095, Stanford, CA 94305 5484, USA
    Mol Cancer Ther 5:2624-33. 2006
    ..Molecular imaging has enormous potential in improving the efficiency of the drug development process, including the specific area of antiangiogenic drugs...
  56. doi request reprint Chapter 7. Molecular imaging of tumor vasculature
    Weibo Cai
    Stanford University School of Medicine, Stanford, California, USA
    Methods Enzymol 445:141-76. 2008
    ....
  57. doi request reprint Positron Emission Tomography Imaging of Angiogenesis in a Murine Hindlimb Ischemia Model with (64)Cu-Labeled TRC105
    Hakan Orbay
    Department of Radiology, Department of Medical Physics, and Department of Medicine, Division of Cardiovascular Medicine, University of Wisconsin Madison, Madison, Wisconsin 53706, United States
    Mol Pharm 10:2749-56. 2013
    ..64)Cu-NOTA-TRC105 PET may play multiple roles in future PAD-related research and improve PAD patient management by identifying the optimal timing of treatment and monitoring the efficacy of therapy. ..
  58. ncbi request reprint Semiconductor quantum dots for in vivo imaging
    Zi Bo Li
    The Molecular Imaging Program at Stanford MIPS, Department of Radiology and Bio X Program, Stanford University, Stanford, CA 94305, USA
    J Nanosci Nanotechnol 7:2567-81. 2007
    ..The integration of quantum dots with other imaging techniques is also expected to give rise to a new generation of multifunctional probes for biomedical applications...
  59. pmc Image-guided and tumor-targeted drug delivery with radiolabeled unimolecular micelles
    Jintang Guo
    School of Chemical Engineering, Tianjin University, Tianjin 300072, China
    Biomaterials 34:8323-32. 2013
    ....
  60. pmc Multifunctional unimolecular micelles for cancer-targeted drug delivery and positron emission tomography imaging
    Yuling Xiao
    Department of Biomedical Engineering and Wisconsin Institutes for Discovery, University of Wisconsin Madison, Madison, WI 53706, USA
    Biomaterials 33:3071-82. 2012
    ....
  61. pmc Positron emission tomography and optical imaging of tumor CD105 expression with a dual-labeled monoclonal antibody
    Yin Zhang
    Department of Medical Physics, University of Wisconsin Madison, Madison, Wisconsin, United States
    Mol Pharm 9:645-53. 2012
    ..Successful PET/NIRF imaging of CD105 expression warrants further investigation and clinical translation of dual-labeled TRC105-based imaging agents...
  62. pmc In vivo near-infrared fluorescence imaging of CD105 expression during tumor angiogenesis
    Yunan Yang
    Department of Radiology, University of Wisconsin Madison, Madison, WI, USA
    Eur J Nucl Med Mol Imaging 38:2066-76. 2011
    ..The goal of this study is to evaluate tumor angiogenesis in a mouse model by near-infrared fluorescence (NIRF) imaging of CD105 expression...
  63. ncbi request reprint Multimodality imaging of the HER-kinase axis in cancer
    Weibo Cai
    The Molecular Imaging Program at Stanford MIPS, Department of Radiology and Bio X Program, Stanford University School of Medicine, 1201 Welch Rd, P095, Stanford, CA 94305 5484, USA
    Eur J Nucl Med Mol Imaging 35:186-208. 2008
    ..Successful development of new HER-kinase-targeted imaging agents with optimal in vivo stability, targeting efficacy, and desirable pharmacokinetics for clinical translation will enable maximum benefit in cancer patient management...
  64. ncbi request reprint Anti-angiogenic cancer therapy based on integrin alphavbeta3 antagonism
    Weibo Cai
    Molecular Imaging Program at Stanford, Department of Radiology and Bio X Program, Stanford University School of Medicine, Stanford, CA 94305 5484, USA
    Anticancer Agents Med Chem 6:407-28. 2006
    ..Lastly, integrin targeted delivery (drugs, genes, and radioisotopes) and imaging (optical, MRI, ultrasound, SPECT, and PET) is discussed in detail...
  65. pmc Chelator-Free Synthesis of a Dual-Modality PET/MRI Agent
    Feng Chen
    Department of Radiology, University of Wisconsin Madison, 1111 Highland Avenue, Madison, WI, 53705 USA http mi wisc edu
    Angew Chem Int Ed Engl 52:13319-23. 2013
    ....
  66. pmc PET/SPECT imaging of hindlimb ischemia: focusing on angiogenesis and blood flow
    Hakan Orbay
    Department of Radiology, School of Medicine and Public Health, University of Wisconsin, Madison, 1111 Highland Ave, Room 7137, Madison, WI 53705 2275, USA
    Angiogenesis 16:279-87. 2013
    ..In this review article, we summarize the PET/SPECT tracers that have been tested in the murine hindlimb ischemia model as well as those used clinically to assess the extremity blood flow...
  67. pmc Positron emission tomography imaging of CD105 expression during tumor angiogenesis
    Hao Hong
    Department of Radiology, University of Wisconsin Madison, Madison, WI 53705 2275, USA
    Eur J Nucl Med Mol Imaging 38:1335-43. 2011
    ..The goal of this study was to develop a positron emission tomography (PET) tracer for imaging CD105 expression...
  68. pmc PET tracers based on Zirconium-89
    Yin Zhang
    Departments of Radiology and Medical Physics, School of Medicine and Public Health, University ofWisconsin Madison, Madison, WI 53705 2275, USA
    Curr Radiopharm 4:131-9. 2011
    ....
  69. ncbi request reprint Peptide-labeled near-infrared quantum dots for imaging tumor vasculature in living subjects
    Weibo Cai
    Molecular Imaging Program MIPS, Department of Radiology, Stanford University School of Medicine, Stanford, California 94305, USA
    Nano Lett 6:669-76. 2006
    ..The results reported here open up new perspectives for integrin-targeted near-infrared optical imaging and may aid in cancer detection and management including imaging-guided surgery...
  70. pmc Near-infrared fluorescence imaging of tumor integrin alpha v beta 3 expression with Cy7-labeled RGD multimers
    Yun Wu
    Molecular Imaging Program at Stanford MIPS, Department of Radiology and Bio X Program, Stanford University School of Medicine, 1201 Welch Rd, P095, Stanford, CA 94305 5484, USA
    Mol Imaging Biol 8:226-36. 2006
    ..Here, we describe the development of near-infrared (NIR) fluorochrome Cy7-labeled RGD peptides for tumor integrin targeting...
  71. pmc Positron emission tomography imaging of prostate cancer
    Hao Hong
    Department of Radiology, School of Medicine and Public Health, University of Wisconsin Madison, 1111 Highland Avenue, Madison, WI 53705 2275, USA
    Amino Acids 39:11-27. 2010
    ..Lastly, we will identify future directions for the development of novel PET tracers for PCa imaging, which may eventually lead to personalized management of PCa patients...
  72. ncbi request reprint Molecular imaging of human epidermal growth factor receptor 2 (HER-2) expression
    Gang Niu
    The Molecular Imaging Program at Stanford, Department of Radiology, Stanford University School of Medicine, Stanford, California 94305, USA
    Front Biosci 13:790-805. 2008
    ..Successful development of new HER-2 targeted imaging agents with optimal in vivo stability, targeting efficacy, and desirable pharmacokinetics for clinical translation will enable maximum benefit in cancer patient management...
  73. pmc Imaging with Raman spectroscopy
    Yin Zhang
    Department Medical Physics, School of Medicine and Public Health, University of Wisconsin Madison, Madison, WI 53705 2275, USA
    Curr Pharm Biotechnol 11:654-61. 2010
    ..It is expected that imaging with Raman Spectroscopy will continue to be a dynamic research field over the next decade...
  74. pmc Non-invasive imaging of human embryonic stem cells
    Hao Hong
    Department of Radiology, School of Medicine and Public Health, University of Wisconsin Madison, Madison, WI 53705 2275, USA
    Curr Pharm Biotechnol 11:685-92. 2010
    ..Continued evolvement of non-invasive imaging techniques will undoubtedly contribute to significant advances in understanding stem cell biology and mechanisms of action...
  75. doi request reprint Multimodality imaging of nitric oxide and nitric oxide synthases
    Hao Hong
    Department of Radiology, School of Medicine and Public Health, University of Wisconsin Madison, Madison, Wisconsin 53705 2275, USA
    Free Radic Biol Med 47:684-98. 2009
    ..Successful development of novel NO/NOS imaging agents with optimal in vivo stability and desirable pharmacokinetics for clinical translation will enable the maximum benefit in patient management...
  76. ncbi request reprint Multimodality imaging of vascular endothelial growth factor and vascular endothelial growth factor receptor expression
    Weibo Cai
    The Molecular Imaging Program at Stanford MIPS, Department of Radiology and Bio X Program, Stanford University School of Medicine, Stanford, California 94305, USA
    Front Biosci 12:4267-79. 2007
    ..With the development of new tracers with better targeting efficacy and desirable pharmacokinetics, clinical translation will be critical for the maximum benefit of VEGF/VEGFR targeted imaging agents...
  77. pmc Non-invasive cell tracking in cancer and cancer therapy
    Hao Hong
    Department of Radiology, School of Medicine and Public Health, University of Wisconsin Madison, 1111 Highland Avenue, Room 7137, Madison, WI 53705, USA
    Curr Top Med Chem 10:1237-48. 2010
    ..MRI, radionuclide-based imaging techniques, and reporter gene-based approaches will each have their own niches towards the same ultimate goal: personalized medicine for cancer patients...
  78. ncbi request reprint Nanoplatforms for targeted molecular imaging in living subjects
    Weibo Cai
    Molecular Imaging Program at Stanford MIPS, Department of Radiology and Bio X Program, Stanford University, Stanford, CA 94305, USA
    Small 3:1840-54. 2007
    ..In this Review, we will summarize the current state-of-the-art of nanoplatforms for targeted molecular imaging in living subjects...
  79. pmc Imaging of Abdominal Aortic Aneurysm: the present and the future
    Hao Hong
    Department of Radiology, School of Medicine and Public Health, University of Wisconsin Madison, Madison, WI 53705 2275, USA
    Curr Vasc Pharmacol 8:808-19. 2010
    ..Equally important, the right imaging probe will also allow scientists/clinicians to acquire critical data during AAA development and to more accurately evaluate the efficacy of potential treatments...
  80. pmc Molecular imaging with SERS-active nanoparticles
    Yin Zhang
    Department of Medical Physics, University of Wisconsin Madison, Room 7137, 1111 Highland Ave, Madison, WI 53705 2275, USA
    Small 7:3261-9. 2011
    ..It is expected that SERS-based imaging will continue to be a dynamic research field over the next decade...
  81. pmc Anatomical and molecular imaging of skin cancer
    Hao Hong
    Departments of Radiology and Medical Physics, School of Medicine and Public Health, University of Wisconsin Madison, Madison, Wisconsin, USA
    Clin Cosmet Investig Dermatol 1:1-17. 2008
    ..It is likely that this situation will change in the near future and molecular imaging will truly play an important role in personalized medicine of melanoma patients...
  82. pmc Multimodality Imaging of Integrin α(v)β(3) Expression
    Yin Zhang
    1 Departments of Radiology and Medical Physics, School of Medicine and Public Health, University of Wisconsin Madison, USA
    Theranostics 1:135-48. 2011
    ..The next decade will likely witness further growth and continued prosperity of molecular imaging studies focusing on integrin α(v)β(3), which can eventually impact patient management...
  83. ncbi request reprint 18F-labeled bombesin analogs for targeting GRP receptor-expressing prostate cancer
    Xianzhong Zhang
    Molecular Imaging Program at Stanford MIPS, Department of Radiology and Bio X Program, Stanford University School of Medicine, Stanford, California 94305 5484, USA
    J Nucl Med 47:492-501. 2006
    ..The gastrin-releasing peptide receptor (GRPR) is found to be overexpressed in a variety of human tumors. The aim of this study was to develop 18F-labeled bombesin analogs for PET of GRPR expression in prostate cancer xenograft models...
  84. ncbi request reprint Quantitative PET imaging of tumor integrin alphavbeta3 expression with 18F-FRGD2
    Xianzhong Zhang
    Molecular Imaging Program at Stanford, MIPS, and Bio X Program, Department of Radiology, Stanford University, California 94305 5484, USA
    J Nucl Med 47:113-21. 2006
    ..We labeled the dimeric RGD peptide E[c(RGDyK)](2) with (18)F and evaluated its tumor-targeting efficacy and pharmacokinetics of (18)F-FB-E[c(RGDyK)](2) ((18)F-FRGD2)...
  85. pmc Imaging of VEGF receptor in a rat myocardial infarction model using PET
    Martin Rodriguez-Porcel
    Molecular Imaging Program at Stanford, Department of Radiology, Division of Nuclear Medicine, Stanford University, Stanford, CA 94305 5427, USA
    J Nucl Med 49:667-73. 2008
    ..We have developed a PET tracer (64Cu-DOTA-VEGF121 [DOTA is 1,4,7,10-tetraazadodecane-N,N',N'',N'''-tetraacetic acid]) to image VEGF receptor (VEGFR) expression after MI in the living subject...