Michael Cahalan

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc A store-operated calcium channel in Drosophila S2 cells
    Andriy V Yeromin
    Department of Physiology and Biophysics, University of California, Irvine, CA 92697 4561, USA
    J Gen Physiol 123:167-82. 2004
  2. pmc Imaging the single cell dynamics of CD4+ T cell activation by dendritic cells in lymph nodes
    Mark J Miller
    Department of Physiology and Biophysics, University of California, Irvine, CA 92697, USA
    J Exp Med 200:847-56. 2004
  3. pmc The CRAC channel consists of a tetramer formed by Stim-induced dimerization of Orai dimers
    Aubin Penna
    Department of Physiology and Biophysics, University of California Irvine, California 92697 4561, USA
    Nature 456:116-20. 2008
  4. pmc Quantum dots for tracking dendritic cells and priming an immune response in vitro and in vivo
    Debasish Sen
    Department of Physiology and Biophysics, University of California Irvine, Irvine, California, United States of America
    PLoS ONE 3:e3290. 2008
  5. pmc Distinct properties of CRAC and MIC channels in RBL cells
    J Ashot Kozak
    Department of Physiology and Biophysics, University of California at Irvine, Irvine, CA 92697, USA
    J Gen Physiol 120:221-35. 2002
  6. pmc Charge screening by internal pH and polyvalent cations as a mechanism for activation, inhibition, and rundown of TRPM7/MIC channels
    J Ashot Kozak
    Department of Physiology and Biophysics, School of Medicine, University of California, Irvine, CA 92697, USA
    J Gen Physiol 126:499-514. 2005
  7. pmc Three phases of CD8 T cell response in the lung following H1N1 influenza infection and sphingosine 1 phosphate agonist therapy
    Melanie P Matheu
    Department of Physiology and Biophysics and the Center for Immunology, University of California Irvine, Irvine, California, United States of America
    PLoS ONE 8:e58033. 2013
  8. pmc Orai3 TM3 point mutation G158C alters kinetics of 2-APB-induced gating by disulfide bridge formation with TM2 C101
    Anna Amcheslavsky
    Department of Physiology and Biophysics, University of California, Irvine, Irvine, CA 92697
    J Gen Physiol 142:405-12. 2013
  9. pmc Antigen-engaged B cells undergo chemotaxis toward the T zone and form motile conjugates with helper T cells
    Takaharu Okada
    Howard Hughes Medical Institute, Department of Microbiology and Immunology, University of California, San Francisco, California, USA
    PLoS Biol 3:e150. 2005
  10. pmc The immunological synapse: a dynamic platform for local signaling
    Matthew F Krummel
    Department of Pathology, University of California San Francisco, 513 Parnassus Avenue HSW 0511, San Francisco, CA 94143, USA
    J Clin Immunol 30:364-72. 2010

Collaborators

Detail Information

Publications50

  1. pmc A store-operated calcium channel in Drosophila S2 cells
    Andriy V Yeromin
    Department of Physiology and Biophysics, University of California, Irvine, CA 92697 4561, USA
    J Gen Physiol 123:167-82. 2004
    ..We conclude that S2 cells express store-operated Ca2+ channels with many of the same biophysical characteristics as CRAC channels in mammalian cells...
  2. pmc Imaging the single cell dynamics of CD4+ T cell activation by dendritic cells in lymph nodes
    Mark J Miller
    Department of Physiology and Biophysics, University of California, Irvine, CA 92697, USA
    J Exp Med 200:847-56. 2004
    ..Furthermore, the serial nature of these interactions implies that T cells activate by way of multiple antigen recognition events...
  3. pmc The CRAC channel consists of a tetramer formed by Stim-induced dimerization of Orai dimers
    Aubin Penna
    Department of Physiology and Biophysics, University of California Irvine, California 92697 4561, USA
    Nature 456:116-20. 2008
    ..This represents a new mechanism in which assembly and activation of the functional ion channel are mediated by the same triggering molecule...
  4. pmc Quantum dots for tracking dendritic cells and priming an immune response in vitro and in vivo
    Debasish Sen
    Department of Physiology and Biophysics, University of California Irvine, Irvine, California, United States of America
    PLoS ONE 3:e3290. 2008
    ..These results establish QDs as a versatile platform for immunoimaging of dendritic cells and as an efficient nanoparticle-based antigen delivery system for priming an immune response...
  5. pmc Distinct properties of CRAC and MIC channels in RBL cells
    J Ashot Kozak
    Department of Physiology and Biophysics, University of California at Irvine, Irvine, CA 92697, USA
    J Gen Physiol 120:221-35. 2002
    ..The biophysical characteristics of MIC current match well with cloned and expressed TRPM7 channels. Previous results are reevaluated in terms of separate CRAC and MIC channels...
  6. pmc Charge screening by internal pH and polyvalent cations as a mechanism for activation, inhibition, and rundown of TRPM7/MIC channels
    J Ashot Kozak
    Department of Physiology and Biophysics, School of Medicine, University of California, Irvine, CA 92697, USA
    J Gen Physiol 126:499-514. 2005
    ..We propose that MIC (TRPM7) channels are regulated by a charge screening mechanism and may function as sensors of intracellular pH...
  7. pmc Three phases of CD8 T cell response in the lung following H1N1 influenza infection and sphingosine 1 phosphate agonist therapy
    Melanie P Matheu
    Department of Physiology and Biophysics and the Center for Immunology, University of California Irvine, Irvine, California, United States of America
    PLoS ONE 8:e58033. 2013
    ..In addition, we suggest that phase lags in T cell and DC dynamics induced by targeting S1P receptors in vivo may attenuate the intensity of the immune response and can be manipulated for therapeutic benefit...
  8. pmc Orai3 TM3 point mutation G158C alters kinetics of 2-APB-induced gating by disulfide bridge formation with TM2 C101
    Anna Amcheslavsky
    Department of Physiology and Biophysics, University of California, Irvine, Irvine, CA 92697
    J Gen Physiol 142:405-12. 2013
    ..Our data provide functional confirmation of the proximity of these two residues and suggest a location within the Orai3 protein that is sensitive to the actions of 2-APB. ..
  9. pmc Antigen-engaged B cells undergo chemotaxis toward the T zone and form motile conjugates with helper T cells
    Takaharu Okada
    Howard Hughes Medical Institute, Department of Microbiology and Immunology, University of California, San Francisco, California, USA
    PLoS Biol 3:e150. 2005
    ..These findings provide evidence of lymphocyte chemotaxis in vivo, and they begin to define the spatiotemporal cellular dynamics associated with T cell-dependent antibody responses...
  10. pmc The immunological synapse: a dynamic platform for local signaling
    Matthew F Krummel
    Department of Pathology, University of California San Francisco, 513 Parnassus Avenue HSW 0511, San Francisco, CA 94143, USA
    J Clin Immunol 30:364-72. 2010
    ..The entire process of IS formation and extinction is now known to entail a dynamic reorganization of membrane domains and proteins within and adjacent to those domains...
  11. pmc STIMulating store-operated Ca(2+) entry
    Michael D Cahalan
    Department of Physiology and Biophysics and Institute for Immunology, University of California, Irvine, CA 92697 4561, USA
    Nat Cell Biol 11:669-77. 2009
    ....
  12. pmc Real-time imaging of lymphocytes in vivo
    Michael D Cahalan
    Department of Physiology and Biophysics, University of California, Irvine, California 92697, USA
    Curr Opin Immunol 15:372-7. 2003
    ..The view is emerging that lymphocytes migrate randomly within lymphoid organs, and that lymphocyte contact with antigen-presenting cells may be a stochastic process rather than one guided by chemokine gradients...
  13. pmc Close encounters of the first and second kind: T-DC and T-B interactions in the lymph node
    Michael D Cahalan
    Department of Physiology and Biophysics and Center for Immunology, University of California, Irvine, CA 92697 4561, USA
    Semin Immunol 17:442-51. 2005
    ..In this topical review, we compare the activation choreography of CD4+ T cells interacting first with dendritic cells, and then with B cells, during initiation of the humoral immune response...
  14. pmc The sense of place in the immune system
    Michael D Cahalan
    Department of Physiology and Biophysics, University of California, Irvine, California 92697, USA
    Nat Immunol 7:329-32. 2006
    ....
  15. pmc Molecular basis of the CRAC channel
    Michael D Cahalan
    Department of Physiology and Biophysics and Center for Immunology, University of California, Irvine, CA 92697, United States
    Cell Calcium 42:133-44. 2007
    ....
  16. pmc The functional network of ion channels in T lymphocytes
    Michael D Cahalan
    Department of Physiology and Biophysics, and the Institute for Immunology, University of California, Irvine, Irvine, CA 92697 4561, USA
    Immunol Rev 231:59-87. 2009
    ....
  17. pmc Choreography of cell motility and interaction dynamics imaged by two-photon microscopy in lymphoid organs
    Michael D Cahalan
    Department of Physiology and Biophysics, University of California, Irvine, California 92697, USA
    Annu Rev Immunol 26:585-626. 2008
    ....
  18. ncbi request reprint Ion channels in the immune system as targets for immunosuppression
    M D Cahalan
    Department of Physiology and Biophysics, University of California, Irvine 92697 4560, USA
    Curr Opin Biotechnol 8:749-56. 1997
    ..Ion channels may provide excellent pharmaceutical targets for modulating immune system function...
  19. ncbi request reprint Molecular properties and physiological roles of ion channels in the immune system
    M D Cahalan
    Department of Physiology and Biophysics, University of California, Irvine 92697, USA
    J Clin Immunol 21:235-52. 2001
    ..This review surveys recent progress at the biophysical, molecular, and functional roles of the ion channels found in T lymphocytes...
  20. pmc STIM1 is a Ca2+ sensor that activates CRAC channels and migrates from the Ca2+ store to the plasma membrane
    Shenyuan L Zhang
    Department of Physiology and Biophysics and Center for Immunology, University of California, Irvine, California 92697, USA
    Nature 437:902-5. 2005
    ..We propose that STIM1 functions as the missing link between Ca2+ store depletion and SOC influx, serving as a Ca2+ sensor that translocates upon store depletion to the plasma membrane to activate CRAC channels...
  21. ncbi request reprint Two-photon imaging of lymphocyte motility and antigen response in intact lymph node
    Mark J Miller
    Department of Physiology and Biophysics, University of California, Irvine, CA 92697 4561, USA
    Science 296:1869-73. 2002
    ..Antigenic challenge changed T cell trajectories from random walks to "swarms" and stable clusters. Real-time two-photon imaging reveals lymphocyte behaviors that are fundamental to the initiation of the immune response...
  22. pmc Imaging of effector memory T cells during a delayed-type hypersensitivity reaction and suppression by Kv1.3 channel block
    Melanie P Matheu
    Department of Physiology and Biophysics, University of California, Irvine, Irvine, CA 92697 4561, USA
    Immunity 29:602-14. 2008
    ..3 channels in Tem cells during an inflammatory immune response in peripheral tissues. Targeting Kv1.3 allows for effector memory responses to be suppressed while central memory responses remain intact...
  23. pmc Imaging the choreography of lymphocyte trafficking and the immune response
    Michael D Cahalan
    Department of Physiology and Biophysics and Neurobiology and Behavior, University of California, Irvine, 92697, USA
    Curr Opin Immunol 18:476-82. 2006
    ..Recently, advances have been made in these areas of research, as exemplified by studies investigating T cell-dendritic cell interactions, T cell-B cell interactions, and the regulation of lymphocyte egress from the lymph node...
  24. pmc Orai1 and STIM1 move to the immunological synapse and are up-regulated during T cell activation
    Maria I Lioudyno
    Department of Physiology and Biophysics, University of California, Irvine, CA 92697, USA
    Proc Natl Acad Sci U S A 105:2011-6. 2008
    ..These results imply a positive feedback loop in which an initial TCR signal favors up-regulation of STIM1 and Orai proteins that would augment Ca2+ signaling during subsequent antigen encounter...
  25. ncbi request reprint Ca2+ signals in CD4+ T cells during early contacts with antigen-bearing dendritic cells in lymph node
    Sindy H Wei
    Department of Physiology and Biophysics, University of California, Irvine, CA 92697, USA
    J Immunol 179:1586-94. 2007
    ..We propose that sustained increases in basal [Ca(2+)](i) and spiking frequency constitute a Ca(2+) signaling modality that, integrated over hours, distinguishes immunogenic from basal state in the native lymphoid environment...
  26. ncbi request reprint Two-photon imaging in intact lymphoid tissue
    Sindy H Wei
    Department of Physiology and Biophysics, University of California, Irvine 92697 4561, USA
    Adv Exp Med Biol 512:203-8. 2002
  27. pmc K+ channels as targets for specific immunomodulation
    K George Chandy
    Department of Physiology and Biophysics, University of California, Irvine, CA 92697, USA
    Trends Pharmacol Sci 25:280-9. 2004
    ..3 and IKCa1 channels, and provide a rationale for the potential therapeutic use of these inhibitors in immunological disorders...
  28. pmc Two-photon tissue imaging: seeing the immune system in a fresh light
    Michael D Cahalan
    Department of Physiology, University of California, Irvine, California 92697 4561, USA
    Nat Rev Immunol 2:872-80. 2002
    ..Two-photon microscopy, in combination with newly developed indicator molecules, promises to extend single-cell approaches to the in vivo setting and to reveal in detail the cellular collaborations that underlie the immune response...
  29. pmc Store-dependent and -independent modes regulating Ca2+ release-activated Ca2+ channel activity of human Orai1 and Orai3
    Shenyuan L Zhang
    Department of Physiology and Biophysics, University of California, Irvine, California 92697, USA
    J Biol Chem 283:17662-71. 2008
    ..The Orai3 current induced by 2-APB may reflect a store-independent mode of CRAC channel activation that opens a relatively nonselective cation pore...
  30. ncbi request reprint Class IA phosphoinositide 3-kinase modulates basal lymphocyte motility in the lymph node
    Melanie P Matheu
    Department of Physiology and Biophysics, University of California, Irvine, California 92697, USA
    J Immunol 179:2261-9. 2007
    ..Moreover, we demonstrate distinct roles for catalytic domain function and class IA PI3K regulatory domain activity in lymphocyte motility, homing, and homeostatic localization of mature resting B cells...
  31. ncbi request reprint A novel fluorescent toxin to detect and investigate Kv1.3 channel up-regulation in chronically activated T lymphocytes
    Christine Beeton
    Department of Physiology and Biophysics, University of California, Irvine, California 92697, USA
    J Biol Chem 278:9928-37. 2003
    ..3 up-regulation. ShK-F6CA might be useful for rapid and quantitative detection of Kv1.3(high) expressing cells in normal and diseased tissues, and to visualize the distribution of functional channels in intact cells...
  32. pmc Autonomous T cell trafficking examined in vivo with intravital two-photon microscopy
    Mark J Miller
    Department of Physiology and Biophysics, University of California, Irvine, CA 92697, USA
    Proc Natl Acad Sci U S A 100:2604-9. 2003
    ....
  33. pmc Molecular identification of the CRAC channel by altered ion selectivity in a mutant of Orai
    Andriy V Yeromin
    Department of Physiology and Biophysics and Center for Immunology, University of California, Irvine, California 92697, USA
    Nature 443:226-9. 2006
    ..These results indicate that Orai itself forms the Ca2+-selectivity filter of the CRAC channel...
  34. pmc Regulation of membrane trafficking and subcellular organization of endocytic compartments revealed with FM1-43 in resting and activated human T cells
    Alla F Fomina
    Department of Physiology and Biophysics, University of California, Irvine, CA 92697, USA
    Exp Cell Res 291:150-66. 2003
    ..The present study demonstrates the utility of FM1-43 as a marker of membrane trafficking in T cells and reveals possible mechanisms of its modulation during T cell activation...
  35. pmc Genome-wide RNAi screen of Ca(2+) influx identifies genes that regulate Ca(2+) release-activated Ca(2+) channel activity
    Shenyuan L Zhang
    Department of Physiology and Biophysics, University of California, Irvine, CA 92697, USA
    Proc Natl Acad Sci U S A 103:9357-62. 2006
    ....
  36. ncbi request reprint SK3-1C, a dominant-negative suppressor of SKCa and IKCa channels
    Aaron Kolski-Andreaco
    Department of Physiology and Biophysics, University of California Irvine, Irvine, California 92697, USA
    J Biol Chem 279:6893-904. 2004
    ....
  37. pmc T cell repertoire scanning is promoted by dynamic dendritic cell behavior and random T cell motility in the lymph node
    Mark J Miller
    Department of Physiology and Biophysics, University of California, Irvine, CA 92697, USA
    Proc Natl Acad Sci U S A 101:998-1003. 2004
    ..We conclude that dynamic DC gesticulation and random T cell motility together enhance the stochastic scanning of the T cell repertoire, thereby enabling rapid initiation of the immune response...
  38. ncbi request reprint A stochastic view of lymphocyte motility and trafficking within the lymph node
    Sindy H Wei
    Departments of Physiology and Biophysics, University of California, Irvine, CA 92697 4561, USA
    Immunol Rev 195:136-59. 2003
    ....
  39. ncbi request reprint Sphingosine 1-phosphate type 1 receptor agonism inhibits transendothelial migration of medullary T cells to lymphatic sinuses
    Sindy H Wei
    Department of Physiology and Biophysics and Center for Immunology, University of California, Irvine, California 92697 4561, USA
    Nat Immunol 6:1228-35. 2005
    ..Our results provide visualization of transendothelial migration of T cells into lymphatic sinuses and suggest that S1P(1) agonists act mainly on endothelial cell S1P(1) receptors to inhibit lymphocyte migration...
  40. pmc Polyvalent cations as permeant probes of MIC and TRPM7 pores
    Hubert H Kerschbaum
    Department of Physiology and Biophysics, University of California, Irvine, California 92697 4561 USA
    Biophys J 84:2293-305. 2003
    ..An Eyring rate model is developed to account for I/V characteristics and block of MIC channels by polyvalent cations from the outside...
  41. pmc Natural killer cells actively patrol peripheral lymph nodes forming stable conjugates to eliminate MHC-mismatched targets
    Kym R Garrod
    Department of Physiology, University of California, Irvine, CA 92697 4561, USA
    Proc Natl Acad Sci U S A 104:12081-6. 2007
    ..Taken together our data demonstrate that NK cells are a functionally important component of the LN microenvironment, and that cell motility and effector function are strongly modulated via CD49b manipulation...
  42. pmc MIC channels are inhibited by internal divalent cations but not ATP
    J Ashot Kozak
    Department of Physiology and Biophysics, University of California, Irvine, California 92697, USA
    Biophys J 84:922-7. 2003
    ..We conclude that MIC current inhibition occurs simply by divalent cations...
  43. pmc Selective and site-specific mobilization of dermal dendritic cells and Langerhans cells by Th1- and Th2-polarizing adjuvants
    Debasish Sen
    Department of Physiology and Biophysics and Institute for Immunology, University of California, Irvine, CA 92697 4561, USA
    Proc Natl Acad Sci U S A 107:8334-9. 2010
    ....
  44. ncbi request reprint Modulation of mouse Paneth cell alpha-defensin secretion by mIKCa1, a Ca2+-activated, intermediate conductance potassium channel
    Tokiyoshi Ayabe
    Department of Pathology, College of Medicine, University of California, Irvine, California 92697 4800, USA
    J Biol Chem 277:3793-800. 2002
    ..These results demonstrate that mIKCa1 is modulator of Paneth cell alpha-defensin secretion and disclose an involvement in mucosal defense of the intestinal epithelium against ingested bacterial pathogens...
  45. pmc NK cell patrolling and elimination of donor-derived dendritic cells favor indirect alloreactivity
    Kym R Garrod
    Department of Physiology and Biophysics, University of California, Irvine, CA 92697, USA
    J Immunol 184:2329-36. 2010
    ..We thus propose that rapid elimination of allogeneic DCs limits direct Ag presentation and thereby favors the indirect pathway of alloreactivity...
  46. pmc STIM1, an essential and conserved component of store-operated Ca2+ channel function
    Jack Roos
    Torrey Pines Therapeutics, Inc, La Jolla, CA 92037, USA
    J Cell Biol 169:435-45. 2005
    ..We propose that STIM1, a ubiquitously expressed protein that is conserved from Drosophila to mammalian cells, plays an essential role in SOC influx and may be a common component of SOC and CRAC channels...
  47. ncbi request reprint The ins and outs of polycystin-2 as a calcium release channel
    Michael D Cahalan
    Nat Cell Biol 4:E56-7. 2002
  48. ncbi request reprint STOP! In the name of positive selection
    Michael D Cahalan
    Nat Immunol 6:126-8. 2005
  49. ncbi request reprint Channel function is dissociated from the intrinsic kinase activity and autophosphorylation of TRPM7/ChaK1
    Masayuki Matsushita
    First Department of Physiology, Okayama University Medical School, 2 5 1 Shikata cho, Okayama 700 8558, Japan
    J Biol Chem 280:20793-803. 2005
    ..We conclude that neither current activity nor regulation by internal Mg(2+) is affected by kinase activity or autophosphorylation but that the kinase domain may play a structural role in channel assembly or subcellular localization...
  50. ncbi request reprint Enhancement of capillary leakage and restoration of lymphocyte egress by a chiral S1P1 antagonist in vivo
    M Germana Sanna
    Department of Immunology and The Scripps Research Institute Molecular Screening Center, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
    Nat Chem Biol 2:434-41. 2006
    ..Thus, chemical modulation reveals differences in S1P-S1P1 'set points' among tissues and highlights both mechanistic advantages (lymphocyte sequestration) and risks (pulmonary edema) of therapeutic intervention...

Research Grants49

  1. Functional immuno-imaging of lymphocyte motility and cell interactions in lymph n
    Michael D Cahalan; Fiscal Year: 2010
    ..The second goal is to investigate immunosuppression mediated by blockade of specific ion channels in T lymphocytes - a potassium channel Kv1.3 and a calcium channel Orai1 - for treatment of autoimmune disorders. ..
  2. Molecular Mechanisms of Ion Channel in Cell Membranes
    Michael Cahalan; Fiscal Year: 2002
    ..Through the proposed experiments we hope to define mechanisms that regulate ion channels and corresponding cell functions that underlie the immune response. ..
  3. The Role of Calcium Ions in Lymphocyte Activation
    Michael Cahalan; Fiscal Year: 2002
    ..A further goal of this project is to compare the functional responses of quiescent, activated, and chronically activated auto reactive T cells in light of their differing ion channel phenotypes. ..
  4. Molecular Mechanisms of Ion Channel in Cell Membranes
    Michael Cahalan; Fiscal Year: 2001
    ..Through the proposed experiments we hope to define mechanisms that regulate ion channels and corresponding cell functions that underlie the immune response. ..
  5. CALCIUM IONS AND LYMPHOCYTE ACTIVATION
    Michael Cahalan; Fiscal Year: 2000
    ..They are investigating interactions between cells during antigen presentation, as well as intracellular signaling mechanisms that link membrane receptors with gene expression. ..
  6. MOLECULAR MECHANISMS OF ION CHANNELS IN CELL MEMBRANES
    Michael Cahalan; Fiscal Year: 2000
    ..Through the proposed experiments we hope to define mechanisms that regulate ion channels and corresponding cell functions that underlie the immune response. ..
  7. CALCIUM IONS AND LYMPHOCYTE ACTIVATION
    Michael Cahalan; Fiscal Year: 1999
    ..They are investigating interactions between cells during antigen presentation, as well as intracellular signaling mechanisms that link membrane receptors with gene expression. ..
  8. The Role of Calcium Ions in Lymphocyte Activation
    Michael Cahalan; Fiscal Year: 2003
    ..A further goal of this project is to compare the functional responses of quiescent, activated, and chronically activated auto reactive T cells in light of their differing ion channel phenotypes. ..
  9. Molecular Mechanisms of Ion Channel in Cell Membranes
    Michael Cahalan; Fiscal Year: 2003
    ..Through the proposed experiments we hope to define mechanisms that regulate ion channels and corresponding cell functions that underlie the immune response. ..
  10. Functional Imaging of Lymphocyte Motility and Cell Interactions in Lymph Node
    Michael Cahalan; Fiscal Year: 2009
    ..abstract_text> ..
  11. Functional Imaging of Lymphocyte Motility and Cell Interactions in Lymph Node
    Michael Cahalan; Fiscal Year: 2007
    ....
  12. Molecular Mechanisms of Ion Channels in T Lymphocytes
    Michael Cahalan; Fiscal Year: 2007
    ....
  13. Functional Imaging Lymphocyte Motility/Cell Interactions
    Michael Cahalan; Fiscal Year: 2006
    ....
  14. Molecular Mechanisms of Ion Channel in Cell Membranes
    Michael Cahalan; Fiscal Year: 2005
    ..Through the proposed experiments we hope to define mechanisms that regulate ion channels and corresponding cell functions that underlie the immune response. ..
  15. The Role of Calcium Ions in Lymphocyte Activation
    Michael Cahalan; Fiscal Year: 2005
    ..A further goal of this project is to compare the functional responses of quiescent, activated, and chronically activated auto reactive T cells in light of their differing ion channel phenotypes. ..
  16. The Role of Calcium Ions in Lymphocyte Activation
    Michael Cahalan; Fiscal Year: 2004
    ..A further goal of this project is to compare the functional responses of quiescent, activated, and chronically activated auto reactive T cells in light of their differing ion channel phenotypes. ..
  17. Molecular Mechanisms of Ion Channel in Cell Membranes
    Michael Cahalan; Fiscal Year: 2004
    ..Through the proposed experiments we hope to define mechanisms that regulate ion channels and corresponding cell functions that underlie the immune response. ..
  18. MOLECULAR MECHANISMS IN EXCITABLE MEMBRANES
    Michael Cahalan; Fiscal Year: 1980
    ..In addition to furthering our knowledge of neurotoxins, local anesthetics, and other pharmacologically important compounds, this research aims at a better understanding of normal molecular mechanisms in excitable membranes...
  19. CALCIUM IONS AND LYMPHOCYTE ACTIVATION
    Michael Cahalan; Fiscal Year: 1993
    ..The distribution of ATP receptors in cells of the immune system will be determined. Collectively, these experiments make use of a single-cell approach to clarify signal transduction mechanisms vital to immune system function...
  20. MOLECULAR MECHANISMS OF ION CHANNELS IN CELL MEMBRANES
    Michael Cahalan; Fiscal Year: 1999
    ..Through the proposed experiments we hope to define mechanisms that regulate ion channels and corresponding cell functions that underlie the immune response. ..
  21. THE ROLE OF ION CHANNELS IN LYMPHOCYTE ACTIVATION
    Michael Cahalan; Fiscal Year: 1990
    ....
  22. MOLECULAR MECHANISMS OF ION CHANNELS IN CELL MEMBRANES
    Michael Cahalan; Fiscal Year: 1993
    ....
  23. MOLECULAR MECHANISMS OF ION CHANNELS IN CELL MEMBRANES
    Michael Cahalan; Fiscal Year: 1992
    ....
  24. MOLECULAR MECHANISMS OF ION CHANNELS IN CELL MEMBRANES
    Michael Cahalan; Fiscal Year: 1991
    ....
  25. MOLECULAR MECHANISMS OF ION CHANNELS IN CELL MEMBRANES
    Michael Cahalan; Fiscal Year: 1990
    ....
  26. ROLE OF ION CHANNELS IN LYMPHOCYTE ACTIVATION
    Michael Cahalan; Fiscal Year: 1992
    ....
  27. THE ROLE OF ION CHANNELS IN LYMPHOCYTE ACTIVATION
    Michael Cahalan; Fiscal Year: 1991
    ....