Research Topics
| Anthony R CaggiulaSummaryAffiliation: University of Pittsburgh Country: USA Publications
Research Grants
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Detail Information
Publications
Cue dependency of nicotine self-administration and smokingA R Caggiula
Department of Psychology, 455 Langley Hall, University of Pittsburgh, Pittsburgh, PA 15260, USA
Pharmacol Biochem Behav 70:515-30. 2001....- Environmental stimuli promote the acquisition of nicotine self-administration in ratsAnthony R Caggiula
Department of Psychology, University of Pittsburgh, 3131 Sennott Square, Pittsburgh, PA 15260, USA
Psychopharmacology (Berl) 163:230-7. 2002.... 
The role of nicotine in smoking: a dual-reinforcement modelAnthony R Caggiula
Department of Psychology, 3131 Sennott Square, 210 South Bouquet Street, University of Pittsburgh, Pittsburgh, PA 15260, USA
Nebr Symp Motiv 55:91-109. 2009....- Operant responding for conditioned and unconditioned reinforcers in rats is differentially enhanced by the primary reinforcing and reinforcement-enhancing effects of nicotineNadia Chaudhri
Department of Neuroscience, University of Pittsburgh, Pittsburgh, PA, USA
Psychopharmacology (Berl) 189:27-36. 2006.... - Self-administered and noncontingent nicotine enhance reinforced operant responding in rats: impact of nicotine dose and reinforcement scheduleNadia Chaudhri
Department of Neuroscience, University of Pittsburgh, Pittsburgh, PA, USA
Psychopharmacology (Berl) 190:353-62. 2007.... - Reinforcement enhancing effect of nicotine and its attenuation by nicotinic antagonists in ratsXiu Liu
Department of Psychology, University of Pittsburgh, Pittsburgh, PA 15260, USA
Psychopharmacology (Berl) 194:463-73. 2007..Recent studies have demonstrated that nicotine can enhance operant responding for other nonpharmacological reinforcing stimuli. However, the nature of the reinforcement-enhancing effect of nicotine remains largely unknown... - Mecamylamine attenuates cue-induced reinstatement of nicotine-seeking behavior in ratsXiu Liu
Department of Psychology, University of Pittsburgh, Pittsburgh, PA 15260, USA
Neuropsychopharmacology 32:710-8. 2007.... - Complex interactions between nicotine and nonpharmacological stimuli reveal multiple roles for nicotine in reinforcementNadia Chaudhri
Department of Neuroscience, University of Pittsburgh, Pittsburgh, PA 15260, USA
Psychopharmacology (Berl) 184:353-66. 2006..Although considerable progress has been made, we do not yet fully understand the behavioral and neurobiological basis of nicotine reinforcement, and without this knowledge, treatment strategies aimed at reducing smoking remain deficient... - Conditioned reinforcement in rats established with self-administered nicotine and enhanced by noncontingent nicotineMatthew I Palmatier
Department of Psychology, University of Pittsburgh, 3137 Sennott Square, Pittsburgh, PA 15260, USA
Psychopharmacology (Berl) 195:235-43. 2007..We have proposed that the reinforcement derived from these conditional stimuli can be inflated by a nonassociative "reinforcement-enhancing" effect of nicotine... - Dissociating the primary reinforcing and reinforcement-enhancing effects of nicotine using a rat self-administration paradigm with concurrently available drug and environmental reinforcersMatthew I Palmatier
Department of Psychology, University of Pittsburgh, 3137 Sennott Square, 210 S Bouquet St, Pittsburgh, PA 15260, USA
Psychopharmacology (Berl) 184:391-400. 2006..It serves as a primary reinforcer by increasing the probability of behaviors that result in nicotine delivery. However, nicotine also potently enhances behaviors that result in the delivery of nonpharmacological reinforcers... - Cue-induced reinstatement of nicotine-seeking behavior in rats: effect of bupropion, persistence over repeated tests, and its dependence on training doseXiu Liu
Department of Psychology, University of Pittsburgh, Pittsburgh, PA 15260, USA
Psychopharmacology (Berl) 196:365-75. 2008..In addition, the issue of whether bupropion (an FDA-approved smoking cessation medication) interferes with the conditioned incentive of nicotine cues remains to be addressed... - Metabotropic glutamate 5 receptor (mGluR5) antagonists decrease nicotine seeking, but do not affect the reinforcement enhancing effects of nicotineMatthew I Palmatier
Department of Psychology, University of Pittsburgh, Pittsburgh, PA, USA
Neuropsychopharmacology 33:2139-47. 2008..These findings are consistent with other studies suggesting that mGlu5 receptors mediate nicotine seeking, but do not alter the reinforcement enhancing effects of nicotine... - Bupropion and nicotine enhance responding for nondrug reinforcers via dissociable pharmacological mechanisms in ratsMatthew I Palmatier
Department of Psychology, Kansas State University, Manhattan, KS 66502, USA
Psychopharmacology (Berl) 207:381-90. 2009..One of the most successful pharmacotherapies for smoking cessation, bupropion, also increases responding for nondrug reinforcers such as food and brain stimulation rewards... - The reinforcement enhancing effects of nicotine depend on the incentive value of non-drug reinforcers and increase with repeated drug injectionsMatthew I Palmatier
Department of Psychology, University of Pittsburgh, 3137 Sennott Square, 210 S Bouquet Street, Pittsburgh, PA 15260, USA
Drug Alcohol Depend 89:52-9. 2007.... - The role of nicotinic acetylcholine receptors in the primary reinforcing and reinforcement-enhancing effects of nicotineMatthew I Palmatier
Department of Psychology, University of Pittsburgh, Pittsburgh, PA 15260, USA
Neuropsychopharmacology 32:1098-108. 2007..The two reinforcement-related effects of nicotine are mediated by nAChRs but can be dissociated by acute and chronic profiles... - Adolescent exposure to nicotine results in reinforcement enhancement but does not affect adult responding in ratsMatthew T Weaver
Department of Psychology, University of Pittsburgh, 210 S Bouquet Street, Pittsburgh, PA 15260, USA
Drug Alcohol Depend 125:307-12. 2012.... - Precipitated withdrawal from nicotine reduces reinforcing effects of a visual stimulus for ratsMatthew T Weaver
Department of Psychology, School of Arts and Sciences, University of Pittsburgh, Pittsburgh, PA 15260, USA
Nicotine Tob Res 14:824-32. 2012..However, the effects of continuous nicotine exposure on responding for a non-nicotine reinforcer are unknown, as are the effects of abruptly withdrawing continuous nicotine on behavior maintained by the same reinforcer... - Sex differences in the contribution of nicotine and nonpharmacological stimuli to nicotine self-administration in ratsNadia Chaudhri
Department of Neuroscience, University of Pittsburgh, Pittsburgh, PA 15260, USA
Psychopharmacology (Berl) 180:258-66. 2005.... - Varenicline dose dependently enhances responding for nonpharmacological reinforcers and attenuates the reinforcement-enhancing effects of nicotineMelissa E Levin
Department of Psychology, University of Pittsburgh, Pittsburgh, PA 15260, USA
Nicotine Tob Res 14:299-305. 2012..We assessed the effects of VAR alone and in combination with NIC (0.4 mg/kg) while rats pressed the lever for a moderately reinforcing visual stimulus (VS)... - Reinstatement of nicotine-seeking behavior by drug-associated stimuli after extinction in ratsXiu Liu
Department of Psychology, University of Pittsburgh, 3131 Sennott Square, 210 South Bouquet Street, Pittsburgh, PA 15260, USA
Psychopharmacology (Berl) 184:417-25. 2006..However, there is little investigation on the factors that contribute to the latter effect... - Importance of nonpharmacological factors in nicotine self-administrationAnthony R Caggiula
Department of Psychology, University of Pittsburgh, 3131 Sennott Square, 210 Bouquet Street, 15260, Pittsburgh, PA, USA
Physiol Behav 77:683-7. 2002.... - Self-administered and yoked nicotine produce robust increases in blood pressure and changes in heart rate with modest effects of behavioral contingency in ratsEric C Donny
Department of Psychology, University of Pittsburgh, 210 S Bouquet Street, Pittsburgh, PA 15260, USA
Pharmacol Biochem Behav 99:459-67. 2011..Effects of behavioral contingency were observed, but differences were limited. Other non-pharmacological factors such as baseline shifts potentially related to nicotine-associated cues deserve further attention... - The reinforcement-enhancing effects of nicotine: implications for the relationship between smoking, eating and weightEric C Donny
Department of Psychology, University of Pittsburgh, 210 S Bouquet Street, Pittsburgh, PA 15260, USA
Physiol Behav 104:143-8. 2011..Better understanding of the mechanisms underlying the reinforcement-enhancing effects of nicotine broadly, and the effects on food reinforcement per se, may aid in the development of new treatments with better long term outcomes... - Sex differences in the subjective and reinforcing effects of cigarette nicotine doseKenneth A Perkins
Department of Psychiatry, University of Pittsburgh School of Medicine, 3811 O Hara Street, Pittsburgh, PA 15213, USA
Psychopharmacology (Berl) 163:194-201. 2002..However, sex differences in the reinforcing effects of nicotine dose via cigarette smoking have received little attention... - Operant responding for a visual reinforcer in rats is enhanced by noncontingent nicotine: implications for nicotine self-administration and reinforcementEric C Donny
Department of Psychiatry, Behavioral Pharmacology Research Unit, Johns Hopkins University School of Medicine, Baltimore, MD, USA
Psychopharmacology (Berl) 169:68-76. 2003..Nicotine self-administration and smoking may be largely dependent upon this later action... - Guidelines on nicotine dose selection for in vivo researchShannon G Matta
Department of Pharmacology, College of Medicine, University of Tennessee Health Science Center, 874 Union Avenue, Crowe 115, Memphis, TN 38163, USA
Psychopharmacology (Berl) 190:269-319. 2007..In many cases, such discrepancies could be attributed to the complex variables comprising species-specific in vivo responses to acute or chronic nicotine exposure...
Research Grants
- EFFECTS OF SELF ADMINISTERED VERSUS NONCONTINGENT NICOTIAnthony Caggiula; Fiscal Year: 2003..effects previously reported for experimenter-administered NIC? (4) Does NIC SA produce the same changes in nicotinic cholinergic receptors in the brain as has been reported for experimenter-administered NIC? ..
- SELF ADMINISTERED VS NONCONTINGENT NICOTINEAnthony Caggiula; Fiscal Year: 1999..A method of drug delivery, intravenous infusion, will be used which increases greatly both the degree of control of drug-related cues and the temporal resolution of drug effects. ..
- Effects of Self Administered Versus Noncontigent NicotineAnthony Caggiula; Fiscal Year: 2007..using multiple measures of reinforcement and incentive motivation? (3) Are the dual actions of NIC -- as a primary reinforcer and an enhancer of the reinforcing properties of other stimuli -- exhibited by other drugs such as cocaine? ..