Anthony R Caggiula

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. ncbi request reprint Cue dependency of nicotine self-administration and smoking
    A R Caggiula
    Department of Psychology, 455 Langley Hall, University of Pittsburgh, Pittsburgh, PA 15260, USA
    Pharmacol Biochem Behav 70:515-30. 2001
  2. ncbi request reprint Environmental stimuli promote the acquisition of nicotine self-administration in rats
    Anthony R Caggiula
    Department of Psychology, University of Pittsburgh, 3131 Sennott Square, Pittsburgh, PA 15260, USA
    Psychopharmacology (Berl) 163:230-7. 2002
  3. pmc The role of nicotine in smoking: a dual-reinforcement model
    Anthony R Caggiula
    Department of Psychology, 3131 Sennott Square, 210 South Bouquet Street, University of Pittsburgh, Pittsburgh, PA 15260, USA
    Nebr Symp Motiv 55:91-109. 2009
  4. ncbi request reprint Operant responding for conditioned and unconditioned reinforcers in rats is differentially enhanced by the primary reinforcing and reinforcement-enhancing effects of nicotine
    Nadia Chaudhri
    Department of Neuroscience, University of Pittsburgh, Pittsburgh, PA, USA
    Psychopharmacology (Berl) 189:27-36. 2006
  5. pmc Self-administered and noncontingent nicotine enhance reinforced operant responding in rats: impact of nicotine dose and reinforcement schedule
    Nadia Chaudhri
    Department of Neuroscience, University of Pittsburgh, Pittsburgh, PA, USA
    Psychopharmacology (Berl) 190:353-62. 2007
  6. pmc Reinforcement enhancing effect of nicotine and its attenuation by nicotinic antagonists in rats
    Xiu Liu
    Department of Psychology, University of Pittsburgh, Pittsburgh, PA 15260, USA
    Psychopharmacology (Berl) 194:463-73. 2007
  7. pmc Mecamylamine attenuates cue-induced reinstatement of nicotine-seeking behavior in rats
    Xiu Liu
    Department of Psychology, University of Pittsburgh, Pittsburgh, PA 15260, USA
    Neuropsychopharmacology 32:710-8. 2007
  8. ncbi request reprint Complex interactions between nicotine and nonpharmacological stimuli reveal multiple roles for nicotine in reinforcement
    Nadia Chaudhri
    Department of Neuroscience, University of Pittsburgh, Pittsburgh, PA 15260, USA
    Psychopharmacology (Berl) 184:353-66. 2006
  9. pmc Conditioned reinforcement in rats established with self-administered nicotine and enhanced by noncontingent nicotine
    Matthew I Palmatier
    Department of Psychology, University of Pittsburgh, 3137 Sennott Square, Pittsburgh, PA 15260, USA
    Psychopharmacology (Berl) 195:235-43. 2007
  10. ncbi request reprint Dissociating the primary reinforcing and reinforcement-enhancing effects of nicotine using a rat self-administration paradigm with concurrently available drug and environmental reinforcers
    Matthew I Palmatier
    Department of Psychology, University of Pittsburgh, 3137 Sennott Square, 210 S Bouquet St, Pittsburgh, PA 15260, USA
    Psychopharmacology (Berl) 184:391-400. 2006

Research Grants

  1. EFFECTS OF SELF ADMINISTERED VERSUS NONCONTINGENT NICOTI
    Anthony Caggiula; Fiscal Year: 2003
  2. SELF ADMINISTERED VS NONCONTINGENT NICOTINE
    Anthony Caggiula; Fiscal Year: 1999
  3. Effects of Self Administered Versus Noncontigent Nicotine
    Anthony Caggiula; Fiscal Year: 2007

Detail Information

Publications26

  1. ncbi request reprint Cue dependency of nicotine self-administration and smoking
    A R Caggiula
    Department of Psychology, 455 Langley Hall, University of Pittsburgh, Pittsburgh, PA 15260, USA
    Pharmacol Biochem Behav 70:515-30. 2001
    ....
  2. ncbi request reprint Environmental stimuli promote the acquisition of nicotine self-administration in rats
    Anthony R Caggiula
    Department of Psychology, University of Pittsburgh, 3131 Sennott Square, Pittsburgh, PA 15260, USA
    Psychopharmacology (Berl) 163:230-7. 2002
    ....
  3. pmc The role of nicotine in smoking: a dual-reinforcement model
    Anthony R Caggiula
    Department of Psychology, 3131 Sennott Square, 210 South Bouquet Street, University of Pittsburgh, Pittsburgh, PA 15260, USA
    Nebr Symp Motiv 55:91-109. 2009
    ....
  4. ncbi request reprint Operant responding for conditioned and unconditioned reinforcers in rats is differentially enhanced by the primary reinforcing and reinforcement-enhancing effects of nicotine
    Nadia Chaudhri
    Department of Neuroscience, University of Pittsburgh, Pittsburgh, PA, USA
    Psychopharmacology (Berl) 189:27-36. 2006
    ....
  5. pmc Self-administered and noncontingent nicotine enhance reinforced operant responding in rats: impact of nicotine dose and reinforcement schedule
    Nadia Chaudhri
    Department of Neuroscience, University of Pittsburgh, Pittsburgh, PA, USA
    Psychopharmacology (Berl) 190:353-62. 2007
    ....
  6. pmc Reinforcement enhancing effect of nicotine and its attenuation by nicotinic antagonists in rats
    Xiu Liu
    Department of Psychology, University of Pittsburgh, Pittsburgh, PA 15260, USA
    Psychopharmacology (Berl) 194:463-73. 2007
    ..Recent studies have demonstrated that nicotine can enhance operant responding for other nonpharmacological reinforcing stimuli. However, the nature of the reinforcement-enhancing effect of nicotine remains largely unknown...
  7. pmc Mecamylamine attenuates cue-induced reinstatement of nicotine-seeking behavior in rats
    Xiu Liu
    Department of Psychology, University of Pittsburgh, Pittsburgh, PA 15260, USA
    Neuropsychopharmacology 32:710-8. 2007
    ....
  8. ncbi request reprint Complex interactions between nicotine and nonpharmacological stimuli reveal multiple roles for nicotine in reinforcement
    Nadia Chaudhri
    Department of Neuroscience, University of Pittsburgh, Pittsburgh, PA 15260, USA
    Psychopharmacology (Berl) 184:353-66. 2006
    ..Although considerable progress has been made, we do not yet fully understand the behavioral and neurobiological basis of nicotine reinforcement, and without this knowledge, treatment strategies aimed at reducing smoking remain deficient...
  9. pmc Conditioned reinforcement in rats established with self-administered nicotine and enhanced by noncontingent nicotine
    Matthew I Palmatier
    Department of Psychology, University of Pittsburgh, 3137 Sennott Square, Pittsburgh, PA 15260, USA
    Psychopharmacology (Berl) 195:235-43. 2007
    ..We have proposed that the reinforcement derived from these conditional stimuli can be inflated by a nonassociative "reinforcement-enhancing" effect of nicotine...
  10. ncbi request reprint Dissociating the primary reinforcing and reinforcement-enhancing effects of nicotine using a rat self-administration paradigm with concurrently available drug and environmental reinforcers
    Matthew I Palmatier
    Department of Psychology, University of Pittsburgh, 3137 Sennott Square, 210 S Bouquet St, Pittsburgh, PA 15260, USA
    Psychopharmacology (Berl) 184:391-400. 2006
    ..It serves as a primary reinforcer by increasing the probability of behaviors that result in nicotine delivery. However, nicotine also potently enhances behaviors that result in the delivery of nonpharmacological reinforcers...
  11. pmc Cue-induced reinstatement of nicotine-seeking behavior in rats: effect of bupropion, persistence over repeated tests, and its dependence on training dose
    Xiu Liu
    Department of Psychology, University of Pittsburgh, Pittsburgh, PA 15260, USA
    Psychopharmacology (Berl) 196:365-75. 2008
    ..In addition, the issue of whether bupropion (an FDA-approved smoking cessation medication) interferes with the conditioned incentive of nicotine cues remains to be addressed...
  12. pmc Metabotropic glutamate 5 receptor (mGluR5) antagonists decrease nicotine seeking, but do not affect the reinforcement enhancing effects of nicotine
    Matthew I Palmatier
    Department of Psychology, University of Pittsburgh, Pittsburgh, PA, USA
    Neuropsychopharmacology 33:2139-47. 2008
    ..These findings are consistent with other studies suggesting that mGlu5 receptors mediate nicotine seeking, but do not alter the reinforcement enhancing effects of nicotine...
  13. pmc Bupropion and nicotine enhance responding for nondrug reinforcers via dissociable pharmacological mechanisms in rats
    Matthew I Palmatier
    Department of Psychology, Kansas State University, Manhattan, KS 66502, USA
    Psychopharmacology (Berl) 207:381-90. 2009
    ..One of the most successful pharmacotherapies for smoking cessation, bupropion, also increases responding for nondrug reinforcers such as food and brain stimulation rewards...
  14. pmc The reinforcement enhancing effects of nicotine depend on the incentive value of non-drug reinforcers and increase with repeated drug injections
    Matthew I Palmatier
    Department of Psychology, University of Pittsburgh, 3137 Sennott Square, 210 S Bouquet Street, Pittsburgh, PA 15260, USA
    Drug Alcohol Depend 89:52-9. 2007
    ....
  15. pmc The role of nicotinic acetylcholine receptors in the primary reinforcing and reinforcement-enhancing effects of nicotine
    Matthew I Palmatier
    Department of Psychology, University of Pittsburgh, Pittsburgh, PA 15260, USA
    Neuropsychopharmacology 32:1098-108. 2007
    ..The two reinforcement-related effects of nicotine are mediated by nAChRs but can be dissociated by acute and chronic profiles...
  16. pmc Adolescent exposure to nicotine results in reinforcement enhancement but does not affect adult responding in rats
    Matthew T Weaver
    Department of Psychology, University of Pittsburgh, 210 S Bouquet Street, Pittsburgh, PA 15260, USA
    Drug Alcohol Depend 125:307-12. 2012
    ....
  17. pmc Precipitated withdrawal from nicotine reduces reinforcing effects of a visual stimulus for rats
    Matthew T Weaver
    Department of Psychology, School of Arts and Sciences, University of Pittsburgh, Pittsburgh, PA 15260, USA
    Nicotine Tob Res 14:824-32. 2012
    ..However, the effects of continuous nicotine exposure on responding for a non-nicotine reinforcer are unknown, as are the effects of abruptly withdrawing continuous nicotine on behavior maintained by the same reinforcer...
  18. ncbi request reprint Sex differences in the contribution of nicotine and nonpharmacological stimuli to nicotine self-administration in rats
    Nadia Chaudhri
    Department of Neuroscience, University of Pittsburgh, Pittsburgh, PA 15260, USA
    Psychopharmacology (Berl) 180:258-66. 2005
    ....
  19. pmc Varenicline dose dependently enhances responding for nonpharmacological reinforcers and attenuates the reinforcement-enhancing effects of nicotine
    Melissa E Levin
    Department of Psychology, University of Pittsburgh, Pittsburgh, PA 15260, USA
    Nicotine Tob Res 14:299-305. 2012
    ..We assessed the effects of VAR alone and in combination with NIC (0.4 mg/kg) while rats pressed the lever for a moderately reinforcing visual stimulus (VS)...
  20. pmc Reinstatement of nicotine-seeking behavior by drug-associated stimuli after extinction in rats
    Xiu Liu
    Department of Psychology, University of Pittsburgh, 3131 Sennott Square, 210 South Bouquet Street, Pittsburgh, PA 15260, USA
    Psychopharmacology (Berl) 184:417-25. 2006
    ..However, there is little investigation on the factors that contribute to the latter effect...
  21. ncbi request reprint Importance of nonpharmacological factors in nicotine self-administration
    Anthony R Caggiula
    Department of Psychology, University of Pittsburgh, 3131 Sennott Square, 210 Bouquet Street, 15260, Pittsburgh, PA, USA
    Physiol Behav 77:683-7. 2002
    ....
  22. pmc Self-administered and yoked nicotine produce robust increases in blood pressure and changes in heart rate with modest effects of behavioral contingency in rats
    Eric C Donny
    Department of Psychology, University of Pittsburgh, 210 S Bouquet Street, Pittsburgh, PA 15260, USA
    Pharmacol Biochem Behav 99:459-67. 2011
    ..Effects of behavioral contingency were observed, but differences were limited. Other non-pharmacological factors such as baseline shifts potentially related to nicotine-associated cues deserve further attention...
  23. pmc The reinforcement-enhancing effects of nicotine: implications for the relationship between smoking, eating and weight
    Eric C Donny
    Department of Psychology, University of Pittsburgh, 210 S Bouquet Street, Pittsburgh, PA 15260, USA
    Physiol Behav 104:143-8. 2011
    ..Better understanding of the mechanisms underlying the reinforcement-enhancing effects of nicotine broadly, and the effects on food reinforcement per se, may aid in the development of new treatments with better long term outcomes...
  24. ncbi request reprint Sex differences in the subjective and reinforcing effects of cigarette nicotine dose
    Kenneth A Perkins
    Department of Psychiatry, University of Pittsburgh School of Medicine, 3811 O Hara Street, Pittsburgh, PA 15213, USA
    Psychopharmacology (Berl) 163:194-201. 2002
    ..However, sex differences in the reinforcing effects of nicotine dose via cigarette smoking have received little attention...
  25. ncbi request reprint Operant responding for a visual reinforcer in rats is enhanced by noncontingent nicotine: implications for nicotine self-administration and reinforcement
    Eric C Donny
    Department of Psychiatry, Behavioral Pharmacology Research Unit, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Psychopharmacology (Berl) 169:68-76. 2003
    ..However, stimulant drugs also potentiate the rewarding effects of other reinforcers when administered noncontingently...
  26. ncbi request reprint Guidelines on nicotine dose selection for in vivo research
    Shannon G Matta
    Department of Pharmacology, College of Medicine, University of Tennessee Health Science Center, 874 Union Avenue, Crowe 115, Memphis, TN 38163, USA
    Psychopharmacology (Berl) 190:269-319. 2007
    ..In many cases, such discrepancies could be attributed to the complex variables comprising species-specific in vivo responses to acute or chronic nicotine exposure...

Research Grants11

  1. EFFECTS OF SELF ADMINISTERED VERSUS NONCONTINGENT NICOTI
    Anthony Caggiula; Fiscal Year: 2003
    ..effects previously reported for experimenter-administered NIC? (4) Does NIC SA produce the same changes in nicotinic cholinergic receptors in the brain as has been reported for experimenter-administered NIC? ..
  2. SELF ADMINISTERED VS NONCONTINGENT NICOTINE
    Anthony Caggiula; Fiscal Year: 1999
    ..A method of drug delivery, intravenous infusion, will be used which increases greatly both the degree of control of drug-related cues and the temporal resolution of drug effects. ..
  3. Effects of Self Administered Versus Noncontigent Nicotine
    Anthony Caggiula; Fiscal Year: 2007
    ..using multiple measures of reinforcement and incentive motivation? (3) Are the dual actions of NIC -- as a primary reinforcer and an enhancer of the reinforcing properties of other stimuli -- exhibited by other drugs such as cocaine? ..