Research Topics
Species | Melissa A CadnapaphornchaiSummaryAffiliation: University of Colorado Denver Country: USA Publications
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Detail Information
Publications
Persistent elevation of urine aquaporin-2 during water loading in a child with nephrogenic syndrome of inappropriate antidiuresis (NSIAD) caused by a R137L mutation in the V2 vasopressin receptorCLEMENT C CHEUNG
Department of Pediatrics, Division of Endocrinology, University of California, San Francisco, San Francisco, CA 94143
Int J Pediatr Endocrinol 2012:3. 2012..In addition, this is the first longitudinal report of a pediatric patient with NSIAD diagnosed in infancy who demonstrates the ability to maintain eunatremia during ad lib dietary intake...- Effect of statin therapy on disease progression in pediatric ADPKD: design and baseline characteristics of participantsMelissa A Cadnapaphornchai
Department of Medicine, University of Colorado Denver, Aurora, CO, USA
Contemp Clin Trials 32:437-45. 2011..Baseline demographic and laboratory data are provided. Results of this study could markedly impact the standard of care for evaluation and treatment of ADPKD in this population... - Magnetic resonance imaging of kidney and cyst volume in children with ADPKDMelissa A Cadnapaphornchai
Department of Pediatrics, PKD Research Group, University of Colorado Denver, and Department of Radiology, The Children s Hospital, 13001 East 17th Place, Box C283, Aurora, CO 80045, USA
Clin J Am Soc Nephrol 6:369-76. 2011..However, no studies have examined the utility of MRI for serial assessment of kidney and cyst volume in children with ADPKD... - Prospective change in renal volume and function in children with ADPKDMelissa A Cadnapaphornchai
Department of Radiology, The Children s Hospital, University of Colorado School of Medicine, Aurora, Colorado, Aurora, Colorado, USA
Clin J Am Soc Nephrol 4:820-9. 2009..Autosomal dominant polycystic kidney disease (ADPKD) is a progressive hereditary disorder affecting children and young adults. Early intervention may be necessary to significantly affect the long-term consequences of this disease... - Increased left ventricular mass in children with autosomal dominant polycystic kidney disease and borderline hypertensionMelissa A Cadnapaphornchai
Department of Medicine, University of Colorado School of Medicine, Denver, Colorado, USA
Kidney Int 74:1192-6. 2008..These findings show that an increase in LVMI may be detected earlier than an increase in renal volume in children with ADPKD and borderline hypertension, suggesting that close monitoring of cardiac status is indicated in these children... 
Molecular analysis of impaired urinary diluting capacity in glucocorticoid deficiencyWeidong Wang
Div. of Renal Diseases and Hypertension, Univ. of Colorado Health Sciences Center, 4200 East 9th Ave, Box B173, Denver, CO 80262, USA
Am J Physiol Renal Physiol 290:F1135-42. 2006..OPC-31260 reversed upregulation and apical trafficking of AQP2 and pAQP2 in association with improved urinary diluting capacity and increased water excretion after oral water loading...- Molecular mechanisms of impaired urinary concentrating ability in glucocorticoid-deficient ratsYung-Chang Chen
Division of Renal Diseases and Hypertension, University of Colorado Health Sciences Center, 4200 East 9th Avenue, Box B173, Denver, CO 80262, USA
J Am Soc Nephrol 16:2864-71. 2005..These events occurred primarily in the relatively oxygen-deficient medulla and may have been initiated, at least in part, by the decrease in mean arterial pressure and thus renal perfusion pressure in this area of the kidney... - Hyperosmolality in vivo upregulates aquaporin 2 water channel and Na-K-2Cl co-transporter in Brattleboro ratsChunling Li
Department of Medicine, University of Colorado School of Medicine, 4200 East 9th Avenue, Box B173, Denver, CO 80262, USA
J Am Soc Nephrol 17:1657-64. 2006..05), and cortex plus outer stripe of outer medulla NKCC2 (142+/-16 versus 100+/-9%; P<0.05). In conclusion, hyperosmolality, secondary to either glucose or NaCl, upregulated renal AQP2 and NKCC2 in vivo in BB rats... - Effect of primary polydipsia on aquaporin and sodium transporter abundanceMelissa A Cadnapaphornchai
Department of Medicine, University of Colorado School of Medicine, Denver 80262, USA
Am J Physiol Renal Physiol 285:F965-71. 2003..We conclude that the impaired urinary concentrating ability associated with primary POLY in rats is due to impaired osmotic equilibration in the collecting duct that is mediated primarily by decreased AQP-2 protein abundance... - Nonosmotic release of vasopressin and renal aquaporins in impaired urinary dilution in hypothyroidismYung-Chang Chen
Univ. of Colorado School of Medicine, 4200 E. Ninth Ave, Box C293, Denver, CO 80262, USA
Am J Physiol Renal Physiol 289:F672-8. 2005..The impairment of maximal solute-free water excretion in HT rats, however, appears also to involve diminished distal fluid delivery... 
Angiogenic growth factors correlate with disease severity in young patients with autosomal dominant polycystic kidney diseaseBerenice Y Reed
Division of Renal Diseases and Hypertension, Department of Medicine, University of Colorado Denver, Aurora, Colorado 80045, USA
Kidney Int 79:128-34. 2011..Thus, the correlation between angiogenic growth factors with both renal and cardiac disease severity is compatible with a possible role for angiogenesis in the early progression of disease in ADPKD...- Design and baseline characteristics of participants in the study of antihypertensive therapy in children and adolescents with autosomal dominant polycystic kidney disease (ADPKD)Melissa A Cadnapaphornchai
Department of Pediatrics, University of Colorado School of Medicine, Denver, Colorado, USA
Contemp Clin Trials 26:211-22. 2005..Baseline demographic and laboratory data for the study groups are reported. Results of this study could significantly impact the standard of care for management of ADPKD in this population... - Evidence for bradykinin as a stimulator of thirstMelissa A Cadnapaphornchai
Department of Medicine, University of Colorado School of Medicine, Denver, CO 80262, USA
Am J Physiol Renal Physiol 286:F875-80. 2004..Furthermore, this dipsogenic effect was reversed by antagonism of bradykinin, thus implicating this hormone in thirst regulation in the rat... - Clinical update on renal aquaporinsYung-Chang Chen
Department of Medicine, University of Colorado Health Sciences Center, Denver, CO 80262, USA
Biol Cell 97:357-71. 2005..The present article reviews current knowledge regarding the function and dysfunction of renal aquaporins in disorders of water metabolism... - Urine interleukin-6 is an early biomarker of acute kidney injury in children undergoing cardiac surgeryPaula Dennen
Department of Medicine, Division of Nephrology, Denver Health and Hospitals, 777 Bannock Street, Denver, CO 80204, USA
Crit Care 14:R181. 2010..Since proximal tubule injury is a hallmark of AKI, we hypothesized that urine IL-6 would increase in AKI due to impaired proximal tubule metabolism of filtered IL-6... - Urinary concentrating defect in hypothyroid rats: role of sodium, potassium, 2-chloride co-transporter, and aquaporinsMelissa A Cadnapaphornchai
Department of Medicine, University of Colorado School of Medicine, Denver, USA
J Am Soc Nephrol 14:566-74. 2003.... - Case report: severe neonatal hyperkalemia due to pseudohypoaldosteronism type 1Bahareh Schweiger
Department of Pediatrics, Divisions of Pediatric Endocrinology, University of Colorado Denver, The Children s Hospital, 13123 E 16th Ave, Aurora, CO 80045, USA
Curr Opin Pediatr 21:269-71. 2009..The evaluation and treatment of children with disorders of mineralocorticoid action are discussed... - An unusual cause of pediatric hypertensionKevin Friedman
Department of Pediatrics, The Children's Hospital, University of Colorado Health Sciences Center, Denver, Colorado 80218, USA
J Pediatr 151:206-12. 2007 - Renal aquaporin water channels: from molecules to human diseaseRobert W Schrier
Department of Medicine, University of Colorado School of Medicine, 4200 East Ninth Avenue, Box B178, Denver, CO 80262, USA
Prog Biophys Mol Biol 81:117-31. 2003..This article reviews current knowledge regarding aquaporin function and dysfunction in water-losing and water-retaining states...