Research Topics
Genomes and GenesSpecies | Kenneth CadiganSummaryAffiliation: University of Michigan Country: USA Publications
Research Grants
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Detail Information
Publications
Wingless signaling induces widespread chromatin remodeling of target lociDavid S Parker
Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, MI 48109 1048
Mol Cell Biol 28:1815-28. 2008..These data suggest that pathway activation induces localized recruitment of TCF/Armadillo/CBP to Wingless response elements, leading to widespread histone acetylation of target loci prior to transcriptional activation...
Wingless blocks bristle formation and morphogenetic furrow progression in the eye through repression of DaughterlessKenneth M Cadigan
Howard Hughes Medical Institute and the Department of Developmental Biology, Stanford University School of Medicine, Beckman Center, Stanford, California 94305, USA
Development 129:3393-402. 2002..These results are summarized in a model where daughterless is a major, but probably not the only, target of wingless action in the eye...- Wnt signaling: complexity at the surfaceKen M Cadigan
Department of Molecular, Cellular and Developmental Biology, University of Michigan, Natural Science Building, Ann Arbor, MI 48109 1048, USA
J Cell Sci 119:395-402. 2006..Additional, conflicting data concern the role of the atypical receptor tyrosine kinase Ryk, which might mediate Wnt signaling independently of Fz and/or function as a Fz co-receptor in some cells... - Wnt signaling--20 years and countingKen M Cadigan
Dept of Molecular, Cellular and Developmental Biology, University of Michigan, 48109-1048, Ann Arbor MI, USA
Trends Genet 18:340-2. 2002 
Wnt/beta-catenin signaling: turning the switchKen M Cadigan
Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, USA
Dev Cell 14:322-3. 2008..Recent work indicates that beta-catenin's intrinsic affinity for TCF is not sufficient for the switch to occur...- C-terminal-binding protein directly activates and represses Wnt transcriptional targets in DrosophilaMing Fang
Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, MI 48109 1048, USA
EMBO J 25:2735-45. 2006..CtBP binds to Wnt-regulated enhancers in a TCF-independent manner and represses target genes in parallel with TCF. Our data indicate dual roles for CtBP as a gene-specific activator and repressor of Wnt target gene transcription... - Splits ends is a tissue/promoter specific regulator of Wingless signalingHua V Lin
Department of Molecular, Cellular and Developmental Biology, University of Michigan, Natural Science Building, Ann Arbor, MI 48109, USA
Development 130:3125-35. 2003..However, it has no detectable role in the embryonic Wingless pathway, suggesting that it is a tissue or promoter-specific factor... - Novel TCF-binding sites specify transcriptional repression by Wnt signallingTimothy A Blauwkamp
Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, MI, USA
EMBO J 27:1436-46. 2008..This study suggests that the sequence of TCF-binding sites allosterically regulates the TCF/Arm complex to effect either transcriptional activation or repression... - Activation of wingless targets requires bipartite recognition of DNA by TCFMikyung V Chang
Department of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, MI 48109 1048, USA
Curr Biol 18:1877-81. 2008..Our data suggest that DNA recognition by fly TCF occurs through a bipartite mechanism, involving both the HMG domain and the C-clamp, which enables TCF to locate and activate WREs in the nucleus... - Spenito and Split ends act redundantly to promote Wingless signalingJinhee L Chang
Department of Molecular, Cellular and Developmental Biology, University of Michigan, Natural Science Building, Ann Arbor, MI 48109 1048, USA
Dev Biol 314:100-11. 2008..We propose that Spen and Nito act redundantly downstream of TCF/Armadillo to activate many Wg transcriptional targets... - Wingless eliminates ommatidia from the edge of the developing eye through activation of apoptosisHua V Lin
Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, MI 48109 1048, USA
Development 131:2409-18. 2004..We consider the implications of these findings for eye development and function in Drosophila and other organisms... - The chromatin remodelers ISWI and ACF1 directly repress Wingless transcriptional targetsYan I Liu
Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, Michigan 48109 1048, USA
Dev Biol 323:41-52. 2008..Our results argue that WG signaling activates target gene expression partly by overcoming the chromatin barrier maintained by ISWI and ACF1... - Cell biology. Wnt signaling glows with RNAiEric R Fearon
Cancer Center, University of Michigan, Ann Arbor, MI 48109, USA
Science 308:801-3. 2005 - Drosophila ptip is essential for anterior/posterior patterning in development and interacts with the PcG and trxG pathwaysMing Fang
Department of Pathology, University of Michigan, Ann Arbor, MI 48109, USA
Development 136:1929-38. 2009..These data suggest a highly conserved function for ptip in epigenetic control of development and differentiation... - Regulation of the feedback antagonist naked cuticle by Wingless signalingJinhee L Chang
Department of Molecular, Cellular and Developmental Biology, University of Michigan, 830 N University Avenue, Ann Arbor, MI 48109 1048, USA
Dev Biol 321:446-54. 2008..The existence of several WREs in the nkd locus may have been necessary to allow the Wg signaling-Nkd feedback circuit to remain intact as Wg expression diversified during animal evolution... - The Drosophila casein kinase Iepsilon/delta Discs overgrown promotes cell survival via activation of DIAP1 expressionJu Guan
Department of Molecular, Cellular and Developmental Biology, University of Michigan, Natural Science Building, Ann Arbor, MI 48109 1048, USA
Dev Biol 303:16-28. 2007..The dco phenotype cannot be explained by defects Wingless (Wg) signaling. We propose that Dco coordinates tissue size by stimulating cell division/growth and blocking apoptosis via activation of DIAP1 expression... - CBP/p300 are bimodal regulators of Wnt signalingJiong Li
Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, MI 48109 1048, USA
EMBO J 26:2284-94. 2007..Subsequent to this interaction, it also has an essential role in mediating the transactivation activity of beta-cat/Arm... - The microRNA miR-8 is a conserved negative regulator of Wnt signalingJennifer A Kennell
Department of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, MI 48109 1048, USA
Proc Natl Acad Sci U S A 105:15417-22. 2008..These findings indicate that miR-8 family members play an evolutionarily conserved role in regulating the Wnt signaling pathway... - Wnt signaling from development to disease: insights from model systemsKen M Cadigan
Department of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, Michigan 48109 1048, USA
Cold Spring Harb Perspect Biol 1:a002881. 2009..These data help flesh out the mechanisms of signaling from the membrane to the nucleus, revealing new protein players and providing novel information about known components of the pathway... - Drosophila split ends homologue SHARP functions as a positive regulator of Wnt/beta-catenin/T-cell factor signaling in neoplastic transformationYing Feng
Department of Internal Medicine, The Cancer Center, University of Michigan, Ann Arbor, Michigan 48109 2200, USA
Cancer Res 67:482-91. 2007..In toto, our findings implicate SHARP as an important positive regulator of Wnt signaling in cancers with beta-catenin dysregulation... - Developmental roles of the Mi-2/NURD-associated protein p66 in DrosophilaCharlene Kon
Department of Developmental Biology, Howard Hughes Medical Institute, Beckman Center, Stanford University School of Medicine, California 94305 5329, USA
Genetics 169:2087-100. 2005..By co-immunoprecipitation, p66 associates with dMi-2, a known NURD complex member... - Regulating morphogen gradients in the Drosophila wingKenneth M Cadigan
Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, USA
Semin Cell Dev Biol 13:83-90. 2002..However, the relationships between each ligand/receptor pair are different. The role of heparan sulfated proteoglycans, endocytosis and novel exovesicles called argosomes in regulating morphogen distribution will also be discussed... - Pygopus, a nuclear PHD-finger protein required for Wingless signaling in DrosophilaDavid S Parker
Department of Molecular, Cellular and Developmental Biology, University of Michigan, Natural Science Building, Ann Arbor 48109, USA
Development 129:2565-76. 2002..Our data argue strongly that Pygopus is a new core component of the Wg signaling pathway that acts downstream or at the level of TCF...
Research Grants
- Transcriptional Activation by Wnt SignalingKenneth M Cadigan; Fiscal Year: 2010..Our work on the role of chromatin modifications in regulating the TCF transcriptional switch will serve as a paradigm to study these processes in mammalian systems. ..
- Identification of new Wnt signaling componentsKenneth Cadigan; Fiscal Year: 2006..Obtaining genetic confirmation of the importance of these putative Wnt signaling components will provide the confidence to pursue their study in the context of cancer biology and as targets for drug discovery. ..
- TISSUE SPECIFICITY OF WINGLESS SIGNALING IN DROSOPHILAKenneth Cadigan; Fiscal Year: 2005..Since the machinery for Wnt signal transduction is also evolutionarily conserved, understanding tissue specific mechanisms of Wg signaling in flies should have broad relevance to other organisms. ..