Kenneth Cadigan

Summary

Affiliation: University of Michigan
Country: USA

Publications

  1. pmc Wingless signaling induces widespread chromatin remodeling of target loci
    David S Parker
    Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, MI 48109 1048
    Mol Cell Biol 28:1815-28. 2008
  2. ncbi request reprint Wingless blocks bristle formation and morphogenetic furrow progression in the eye through repression of Daughterless
    Kenneth M Cadigan
    Howard Hughes Medical Institute and the Department of Developmental Biology, Stanford University School of Medicine, Beckman Center, Stanford, California 94305, USA
    Development 129:3393-402. 2002
  3. ncbi request reprint Wnt signaling: complexity at the surface
    Ken M Cadigan
    Department of Molecular, Cellular and Developmental Biology, University of Michigan, Natural Science Building, Ann Arbor, MI 48109 1048, USA
    J Cell Sci 119:395-402. 2006
  4. ncbi request reprint Wnt signaling--20 years and counting
    Ken M Cadigan
    Dept of Molecular, Cellular and Developmental Biology, University of Michigan, 48109 1048, Ann Arbor MI, USA
    Trends Genet 18:340-2. 2002
  5. doi request reprint Wnt/beta-catenin signaling: turning the switch
    Ken M Cadigan
    Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, USA
    Dev Cell 14:322-3. 2008
  6. pmc C-terminal-binding protein directly activates and represses Wnt transcriptional targets in Drosophila
    Ming Fang
    Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, MI 48109 1048, USA
    EMBO J 25:2735-45. 2006
  7. ncbi request reprint Splits ends is a tissue/promoter specific regulator of Wingless signaling
    Hua V Lin
    Department of Molecular, Cellular and Developmental Biology, University of Michigan, Natural Science Building, Ann Arbor, MI 48109, USA
    Development 130:3125-35. 2003
  8. pmc Novel TCF-binding sites specify transcriptional repression by Wnt signalling
    Timothy A Blauwkamp
    Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, MI, USA
    EMBO J 27:1436-46. 2008
  9. pmc Activation of wingless targets requires bipartite recognition of DNA by TCF
    Mikyung V Chang
    Department of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, MI 48109 1048, USA
    Curr Biol 18:1877-81. 2008
  10. doi request reprint Spenito and Split ends act redundantly to promote Wingless signaling
    Jinhee L Chang
    Department of Molecular, Cellular and Developmental Biology, University of Michigan, Natural Science Building, Ann Arbor, MI 48109 1048, USA
    Dev Biol 314:100-11. 2008

Research Grants

  1. Transcriptional Activation by Wnt Signaling
    Kenneth M Cadigan; Fiscal Year: 2010
  2. Identification of new Wnt signaling components
    Kenneth Cadigan; Fiscal Year: 2006
  3. TISSUE SPECIFICITY OF WINGLESS SIGNALING IN DROSOPHILA
    Kenneth Cadigan; Fiscal Year: 2005

Collaborators

Detail Information

Publications23

  1. pmc Wingless signaling induces widespread chromatin remodeling of target loci
    David S Parker
    Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, MI 48109 1048
    Mol Cell Biol 28:1815-28. 2008
    ..These data suggest that pathway activation induces localized recruitment of TCF/Armadillo/CBP to Wingless response elements, leading to widespread histone acetylation of target loci prior to transcriptional activation...
  2. ncbi request reprint Wingless blocks bristle formation and morphogenetic furrow progression in the eye through repression of Daughterless
    Kenneth M Cadigan
    Howard Hughes Medical Institute and the Department of Developmental Biology, Stanford University School of Medicine, Beckman Center, Stanford, California 94305, USA
    Development 129:3393-402. 2002
    ..These results are summarized in a model where daughterless is a major, but probably not the only, target of wingless action in the eye...
  3. ncbi request reprint Wnt signaling: complexity at the surface
    Ken M Cadigan
    Department of Molecular, Cellular and Developmental Biology, University of Michigan, Natural Science Building, Ann Arbor, MI 48109 1048, USA
    J Cell Sci 119:395-402. 2006
    ..Additional, conflicting data concern the role of the atypical receptor tyrosine kinase Ryk, which might mediate Wnt signaling independently of Fz and/or function as a Fz co-receptor in some cells...
  4. ncbi request reprint Wnt signaling--20 years and counting
    Ken M Cadigan
    Dept of Molecular, Cellular and Developmental Biology, University of Michigan, 48109 1048, Ann Arbor MI, USA
    Trends Genet 18:340-2. 2002
  5. doi request reprint Wnt/beta-catenin signaling: turning the switch
    Ken M Cadigan
    Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, USA
    Dev Cell 14:322-3. 2008
    ..Recent work indicates that beta-catenin's intrinsic affinity for TCF is not sufficient for the switch to occur...
  6. pmc C-terminal-binding protein directly activates and represses Wnt transcriptional targets in Drosophila
    Ming Fang
    Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, MI 48109 1048, USA
    EMBO J 25:2735-45. 2006
    ..CtBP binds to Wnt-regulated enhancers in a TCF-independent manner and represses target genes in parallel with TCF. Our data indicate dual roles for CtBP as a gene-specific activator and repressor of Wnt target gene transcription...
  7. ncbi request reprint Splits ends is a tissue/promoter specific regulator of Wingless signaling
    Hua V Lin
    Department of Molecular, Cellular and Developmental Biology, University of Michigan, Natural Science Building, Ann Arbor, MI 48109, USA
    Development 130:3125-35. 2003
    ..However, it has no detectable role in the embryonic Wingless pathway, suggesting that it is a tissue or promoter-specific factor...
  8. pmc Novel TCF-binding sites specify transcriptional repression by Wnt signalling
    Timothy A Blauwkamp
    Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, MI, USA
    EMBO J 27:1436-46. 2008
    ..This study suggests that the sequence of TCF-binding sites allosterically regulates the TCF/Arm complex to effect either transcriptional activation or repression...
  9. pmc Activation of wingless targets requires bipartite recognition of DNA by TCF
    Mikyung V Chang
    Department of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, MI 48109 1048, USA
    Curr Biol 18:1877-81. 2008
    ..Our data suggest that DNA recognition by fly TCF occurs through a bipartite mechanism, involving both the HMG domain and the C-clamp, which enables TCF to locate and activate WREs in the nucleus...
  10. doi request reprint Spenito and Split ends act redundantly to promote Wingless signaling
    Jinhee L Chang
    Department of Molecular, Cellular and Developmental Biology, University of Michigan, Natural Science Building, Ann Arbor, MI 48109 1048, USA
    Dev Biol 314:100-11. 2008
    ..We propose that Spen and Nito act redundantly downstream of TCF/Armadillo to activate many Wg transcriptional targets...
  11. ncbi request reprint Wingless eliminates ommatidia from the edge of the developing eye through activation of apoptosis
    Hua V Lin
    Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, MI 48109 1048, USA
    Development 131:2409-18. 2004
    ..We consider the implications of these findings for eye development and function in Drosophila and other organisms...
  12. pmc The chromatin remodelers ISWI and ACF1 directly repress Wingless transcriptional targets
    Yan I Liu
    Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, Michigan 48109 1048, USA
    Dev Biol 323:41-52. 2008
    ..Our results argue that WG signaling activates target gene expression partly by overcoming the chromatin barrier maintained by ISWI and ACF1...
  13. ncbi request reprint Cell biology. Wnt signaling glows with RNAi
    Eric R Fearon
    Cancer Center, University of Michigan, Ann Arbor, MI 48109, USA
    Science 308:801-3. 2005
  14. pmc Drosophila ptip is essential for anterior/posterior patterning in development and interacts with the PcG and trxG pathways
    Ming Fang
    Department of Pathology, University of Michigan, Ann Arbor, MI 48109, USA
    Development 136:1929-38. 2009
    ..These data suggest a highly conserved function for ptip in epigenetic control of development and differentiation...
  15. pmc Regulation of the feedback antagonist naked cuticle by Wingless signaling
    Jinhee L Chang
    Department of Molecular, Cellular and Developmental Biology, University of Michigan, 830 N University Avenue, Ann Arbor, MI 48109 1048, USA
    Dev Biol 321:446-54. 2008
    ..The existence of several WREs in the nkd locus may have been necessary to allow the Wg signaling-Nkd feedback circuit to remain intact as Wg expression diversified during animal evolution...
  16. pmc The Drosophila casein kinase Iepsilon/delta Discs overgrown promotes cell survival via activation of DIAP1 expression
    Ju Guan
    Department of Molecular, Cellular and Developmental Biology, University of Michigan, Natural Science Building, Ann Arbor, MI 48109 1048, USA
    Dev Biol 303:16-28. 2007
    ..The dco phenotype cannot be explained by defects Wingless (Wg) signaling. We propose that Dco coordinates tissue size by stimulating cell division/growth and blocking apoptosis via activation of DIAP1 expression...
  17. pmc CBP/p300 are bimodal regulators of Wnt signaling
    Jiong Li
    Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, MI 48109 1048, USA
    EMBO J 26:2284-94. 2007
    ..Subsequent to this interaction, it also has an essential role in mediating the transactivation activity of beta-cat/Arm...
  18. pmc The microRNA miR-8 is a conserved negative regulator of Wnt signaling
    Jennifer A Kennell
    Department of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, MI 48109 1048, USA
    Proc Natl Acad Sci U S A 105:15417-22. 2008
    ..These findings indicate that miR-8 family members play an evolutionarily conserved role in regulating the Wnt signaling pathway...
  19. pmc Wnt signaling from development to disease: insights from model systems
    Ken M Cadigan
    Department of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, Michigan 48109 1048, USA
    Cold Spring Harb Perspect Biol 1:a002881. 2009
    ..These data help flesh out the mechanisms of signaling from the membrane to the nucleus, revealing new protein players and providing novel information about known components of the pathway...
  20. ncbi request reprint Drosophila split ends homologue SHARP functions as a positive regulator of Wnt/beta-catenin/T-cell factor signaling in neoplastic transformation
    Ying Feng
    Department of Internal Medicine, The Cancer Center, University of Michigan, Ann Arbor, Michigan 48109 2200, USA
    Cancer Res 67:482-91. 2007
    ..In toto, our findings implicate SHARP as an important positive regulator of Wnt signaling in cancers with beta-catenin dysregulation...
  21. pmc Developmental roles of the Mi-2/NURD-associated protein p66 in Drosophila
    Charlene Kon
    Department of Developmental Biology, Howard Hughes Medical Institute, Beckman Center, Stanford University School of Medicine, California 94305 5329, USA
    Genetics 169:2087-100. 2005
    ..By co-immunoprecipitation, p66 associates with dMi-2, a known NURD complex member...
  22. ncbi request reprint Regulating morphogen gradients in the Drosophila wing
    Kenneth M Cadigan
    Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, USA
    Semin Cell Dev Biol 13:83-90. 2002
    ..However, the relationships between each ligand/receptor pair are different. The role of heparan sulfated proteoglycans, endocytosis and novel exovesicles called argosomes in regulating morphogen distribution will also be discussed...
  23. ncbi request reprint Pygopus, a nuclear PHD-finger protein required for Wingless signaling in Drosophila
    David S Parker
    Department of Molecular, Cellular and Developmental Biology, University of Michigan, Natural Science Building, Ann Arbor 48109, USA
    Development 129:2565-76. 2002
    ..Our data argue strongly that Pygopus is a new core component of the Wg signaling pathway that acts downstream or at the level of TCF...

Research Grants14

  1. Transcriptional Activation by Wnt Signaling
    Kenneth M Cadigan; Fiscal Year: 2010
    ..Our work on the role of chromatin modifications in regulating the TCF transcriptional switch will serve as a paradigm to study these processes in mammalian systems. ..
  2. Identification of new Wnt signaling components
    Kenneth Cadigan; Fiscal Year: 2006
    ..Obtaining genetic confirmation of the importance of these putative Wnt signaling components will provide the confidence to pursue their study in the context of cancer biology and as targets for drug discovery. ..
  3. TISSUE SPECIFICITY OF WINGLESS SIGNALING IN DROSOPHILA
    Kenneth Cadigan; Fiscal Year: 2005
    ..Since the machinery for Wnt signal transduction is also evolutionarily conserved, understanding tissue specific mechanisms of Wg signaling in flies should have broad relevance to other organisms. ..