Research Topics
| K S CadenheadSummaryAffiliation: University of California Country: USA Publications
Research Grants
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Detail Information
Publications
Ethical implications for clinical practice and future research in "at risk" individualsFiza Singh
Department of Psychiatry, University of California San Diego, San Diego, California 92093 0810, USA
Curr Pharm Des 18:606-12. 2012..Thus it may be prudent to engage at risk populations early and to use broad-spectrum treatments with low risk benefit ratios to relieve functional impairments, while simultaneously studying all subsets of the at risk population...- Vulnerability markers in the schizophrenia spectrum: implications for phenomenology, genetics, and the identification of the schizophrenia prodromeKristin S Cadenhead
Department of Psychiatry, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0810, USA
Psychiatr Clin North Am 25:837-53. 2002..Finally, genetic studies have yet to be performed in SPD... - Neurobiological measures of schizotypal personality disorder: defining an inhibitory endophenotype?Kristin S Cadenhead
Department of Psychiatry, University of California, San Diego, La Jolla, 92093 0810, USA
Am J Psychiatry 159:869-71. 2002.... 
Startle reactivity and prepulse inhibition in prodromal and early psychosis: effects of age, antipsychotics, tobacco and cannabis in a vulnerable populationKristin S Cadenhead
Department of Psychiatry, 0810, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0810, USA
Psychiatry Res 188:208-16. 2011....- Modulation of the startle response and startle laterality in relatives of schizophrenic patients and in subjects with schizotypal personality disorder: evidence of inhibitory deficitsK S Cadenhead
Department of Psychiatry, University of California, San Diego, La Jolla, 92093 0804, USA
Am J Psychiatry 157:1660-8. 2000..The authors hypothesized that nonschizophrenic relatives of patients with schizophrenia would also have prepulse inhibition deficits, thereby reflecting a genetically transmitted susceptibility to sensorimotor gating deficits... - Sensory gating deficits assessed by the P50 event-related potential in subjects with schizotypal personality disorderK S Cadenhead
Department of Psychiatry, University of California, San Diego 92093 0804, USA
Am J Psychiatry 157:55-9. 2000..Although schizotypal subjects have been shown to have deficits in sensorimotor gating as measured by prepulse inhibition, to the authors' knowledge P50 sensory gating in schizotypal personality disorder has yet to be reported... - Cognitive functions in schizotypal personality disorderK S Cadenhead
Department of Psychiatry, University of California, San Diego, La Jolla 92093 0804, USA
Schizophr Res 37:123-32. 1999..Schizotypal personality disordered (SPD) subjects do not have many of the confounds seen in schizophrenic patients, but may have the same pattern of cognitive deficits in attention and executive functioning... - Treatment history in the psychosis prodrome: characteristics of the North American Prodrome Longitudinal Study CohortKristin S Cadenhead
Department of Psychiatry and Biobehavioral Sciences, UCSD, San Diego, California 92093 0810, USA
Early Interv Psychiatry 4:220-6. 2010..The primary aim of this manuscript is to describe the treatment histories of a large cohort of individuals who entered into one of seven prodromal research programs in a North American Prodrome Longitudinal Study consortium... - P50 suppression in individuals at risk for schizophrenia: the convergence of clinical, familial, and vulnerability marker risk assessmentKristin S Cadenhead
Department of Psychiatry, University of California San Diego, La Jolla, California 92093 0810, USA
Biol Psychiatry 57:1504-9. 2005..The aim of the present study was to determine whether individuals "at risk" for schizophrenia have deficits in P50 suppression, a preattentive measure of sensory gating... - Impact of prepulse characteristics on the detection of sensorimotor gating deficits in schizophreniaD L Braff
Department of Psychiatry, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0804, USA
Schizophr Res 49:171-8. 2001.... - Validity of the prodromal risk syndrome for first psychosis: findings from the North American Prodrome Longitudinal StudyScott W Woods
PRIME Prodromal Research Clinic, Department of Psychiatry, Yale University School of Medicine, 34 Park Street, New Haven, CT 06519, USA
Schizophr Bull 35:894-908. 2009..The strong evidence of diagnostic validity for the prodromal risk syndrome for first psychosis raises the question of its evaluation for inclusion in Diagnostic and Statistical Manual of Mental Disorders (Fifth Edition)... - Abnormal auditory N100 amplitude: a heritable endophenotype in first-degree relatives of schizophrenia probandsBruce I Turetsky
Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Biol Psychiatry 64:1051-9. 2008..We report initial results from the COGS dataset of auditory N100 amplitude and gating as candidate endophenotypes... - Endophenotyping schizotypy: a prelude to genetic studies within the schizophrenia spectrumKristin S Cadenhead
Department of Psychiatry, University of California-San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0804, USA
Schizophr Res 54:47-57. 2002..Composite phenotypes can also be developed, which increase the probability of identifying the complex genetic architecture of schizophrenia spectrum disorders, which interact with nongenetic protective and exacerbating factors... - Neuropsychology of the prodrome to psychosis in the NAPLS consortium: relationship to family history and conversion to psychosisLarry J Seidman
Department of Psychiatry, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
Arch Gen Psychiatry 67:578-88. 2010..Early detection and prospective evaluation of clinical high-risk (CHR) individuals who may develop schizophrenia or other psychotic disorders is critical for predicting psychosis onset and for testing preventive interventions... - Course of neurocognitive deficits in the prodrome and first episode of schizophreniaCarol Jahshan
Joint Doctoral Program in Clinical Psychology, San Diego State University University of California, San Diego, USA
Neuropsychology 24:109-20. 2010.... - Information processing deficits of schizophrenia patients: relationship to clinical ratings, gender and medication statusK S Cadenhead
Department of Psychiatry, University of California, San Diego, La Jolla 92093 0804, USA
Schizophr Res 28:51-62. 1997..It is possible that VBM and RT share overlapping or interacting neural substrates... - Startle gating deficits in a large cohort of patients with schizophrenia: relationship to medications, symptoms, neurocognition, and level of functionNeal R Swerdlow
Departments of Psychiatry, School of Medicine, University of California San Diego, La Jolla, CA 92093, USA
Arch Gen Psychiatry 63:1325-35. 2006..Patients with schizophrenia exhibit deficits in automatic, preattentive sensorimotor gating (prepulse inhibition [PPI]) of the startle reflex... 
Inhibition of the P50 cerebral evoked response to repeated auditory stimuli: results from the Consortium on Genetics of SchizophreniaAnn Olincy
Department of Psychiatry, Veterans Affairs Denver Medical Center VISN 19 MIRECC, CO 80045, USA
Schizophr Res 119:175-82. 2010....- Prepulse inhibition and habituation of the startle response are stable neurobiological measures in a normal male populationK S Cadenhead
Department of Psychiatry, University of California, San Diego, La Jolla 92093 0804, USA
Biol Psychiatry 45:360-4. 1999..These data support the hypothesis that PPI and habituation are relatively stable neurobiological markers... - Verbal working memory impairments in individuals with schizophrenia and their first-degree relatives: findings from the Consortium on the Genetics of SchizophreniaWilliam P Horan
Department of Psychiatry and Biobehavioral Sciences, Geffen School of Medicine at University of California Los Angeles, Los Angeles, California 90095 6968, USA
Schizophr Res 103:218-28. 2008.... - Social functioning in young people at risk for schizophreniaJacob S Ballon
University of California, San Diego, Department of Psychiatry, San Diego, CA 92093 0810, USA
Psychiatry Res 151:29-35. 2007..Individuals at risk for schizophrenia have significant functional deficits which may be potential indicators of increased vulnerability for psychosis... - Cannabis abuse and risk for psychosis in a prodromal sampleKarin Kristensen
Department of Psychiatry, 0810, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0810, USA
Psychiatry Res 151:151-4. 2007.... - How does studying schizotypal personality disorder inform us about the prodrome of schizophrenia?Katherine Seeber
Department of Psychiatry, 0810, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
Curr Psychiatry Rep 7:41-50. 2005..The current review details a strategy for researching the schizophrenia prodrome by using information gained from research in schizotypal personality disorder... - The relationship of information-processing deficits and clinical symptoms in schizotypal personality disorderK S Cadenhead
Department of Psychiatry, University of California, San Diego, La Jolla 92093 0804, USA
Biol Psychiatry 40:853-8. 1996..These findings suggest an important relationship between symptoms of SPD and neurophysiologic deficits... - Initial heritability analyses of endophenotypic measures for schizophrenia: the consortium on the genetics of schizophreniaTiffany A Greenwood
Department of Psychiatry, University of California San Diego, La Jolla, USA
Arch Gen Psychiatry 64:1242-50. 2007..Exploration of the genetic architecture of specific endophenotypes may be a powerful strategy for understanding the genetic basis of schizophrenia... - Obstetrical complications in people at risk for developing schizophreniaJacob S Ballon
Department of Psychiatry, 0810, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0810, United States
Schizophr Res 98:307-11. 2008..Obstetrical complications may be an important risk factor in identifying vulnerable subjects and ultimately may, along with other risk factors, be part of an algorithm for determining likelihood of developing schizophrenia... - Visual information processing dysfunction across the developmental course of early psychosisV B Perez
University of California, San Francisco UCSF, CA, USA
Psychol Med 42:2167-79. 2012..It has been suggested that VM impairments may be a vulnerability marker in individuals at risk for developing psychosis... - The Consortium on the Genetics of Endophenotypes in Schizophrenia: model recruitment, assessment, and endophenotyping methods for a multisite collaborationMonica E Calkins
Neuropsychiatry Section, Department of Psychiatry, University of Pennsylvania, 10 Gates, 3400 Spruce St, Philadelphia, PA 19104, USA
Schizophr Bull 33:33-48. 2007..The purpose of this article is to provide a description of the COGS structure and methods, including participant recruitment and assessment... - Risk and protection in prodromal schizophrenia: ethical implications for clinical practice and future researchNasra Haroun
University of California, San Diego, USA
Schizophr Bull 32:166-78. 2006..Finally, our data strengthen the evidence base available to inform the discussion of ethical issues relevant to this important research area... - North American Prodrome Longitudinal Study: a collaborative multisite approach to prodromal schizophrenia researchJean Addington
Centre for Addiction and Mental Health, 250 College Street, Toronto, Ontario, M5T 1R8, Canada
Schizophr Bull 33:665-72. 2007.... - Successful multi-site measurement of antisaccade performance deficits in schizophreniaAllen D Radant
Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, Washington, United States
Schizophr Res 89:320-9. 2007..These results confirm previous findings of antisaccade deficits in schizophrenia subjects and support the use of the antisaccade task as a potential schizophrenia endophenotype in multi-site genetic studies...
Research Grants
- VULNERABILITY MARKERS IN PRODROMAL SCHIZOPHRENIAKristin Cadenhead; Fiscal Year: 2009..The disruption of social networks, education and occupational activity and the high incidence of suicide and crime that often accompany psychosis might be reduced or averted. ..
- Vulnerability Markers in the Prodrome and First Episode of SchizophreniaKristin Cadenhead; Fiscal Year: 2007....
- VULNERABILITY MARKERS IN PRODROMAL SCHIZOPHRENIAKristin Cadenhead; Fiscal Year: 2007..The disruption of social networks, education and occupational activity and the high incidence of suicide and crime that often accompany psychosis might be reduced or averted. ..
- VULNERABILITY MARKERS IN PRODROMAL SCHIZOPHRENIAKristin Cadenhead; Fiscal Year: 2004..The disruption of social networks, education and occupational activity as well as the high incidence of suicide and crime that often accompany psychosis might be reduced or averted. ..
- VULNERABILITY MARKERS IN PRODROMAL SCHIZOPHRENIAKristin S Cadenhead; Fiscal Year: 2010..The disruption of social networks, education and occupational activity and the high incidence of suicide and crime that often accompany psychosis might be reduced or averted. ..