K S Cadenhead

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Between-site reliability of startle prepulse inhibition across two early psychosis consortia
    Kristin S Cadenhead
    Department of Psychiatry, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0810, USA
    Neuroreport 24:626-30. 2013
  2. ncbi request reprint Ethical implications for clinical practice and future research in "at risk" individuals
    Fiza Singh
    Department of Psychiatry, University of California San Diego, San Diego, California 92093 0810, USA
    Curr Pharm Des 18:606-12. 2012
  3. ncbi request reprint Cognitive functions in schizotypal personality disorder
    K S Cadenhead
    Department of Psychiatry, University of California, San Diego, La Jolla 92093 0804, USA
    Schizophr Res 37:123-32. 1999
  4. ncbi request reprint Sensory gating deficits assessed by the P50 event-related potential in subjects with schizotypal personality disorder
    K S Cadenhead
    Department of Psychiatry, University of California, San Diego 92093 0804, USA
    Am J Psychiatry 157:55-9. 2000
  5. ncbi request reprint Modulation of the startle response and startle laterality in relatives of schizophrenic patients and in subjects with schizotypal personality disorder: evidence of inhibitory deficits
    K S Cadenhead
    Department of Psychiatry, University of California, San Diego, La Jolla, 92093 0804, USA
    Am J Psychiatry 157:1660-8. 2000
  6. pmc Startle reactivity and prepulse inhibition in prodromal and early psychosis: effects of age, antipsychotics, tobacco and cannabis in a vulnerable population
    Kristin S Cadenhead
    Department of Psychiatry, 0810, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0810, USA
    Psychiatry Res 188:208-16. 2011
  7. ncbi request reprint Neurobiological measures of schizotypal personality disorder: defining an inhibitory endophenotype?
    Kristin S Cadenhead
    Department of Psychiatry, University of California, San Diego, La Jolla, 92093 0810, USA
    Am J Psychiatry 159:869-71. 2002
  8. ncbi request reprint Vulnerability markers in the schizophrenia spectrum: implications for phenomenology, genetics, and the identification of the schizophrenia prodrome
    Kristin S Cadenhead
    Department of Psychiatry, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0810, USA
    Psychiatr Clin North Am 25:837-53. 2002
  9. pmc Treatment history in the psychosis prodrome: characteristics of the North American Prodrome Longitudinal Study Cohort
    Kristin S Cadenhead
    Department of Psychiatry and Biobehavioral Sciences, UCSD, San Diego, California 92093 0810, USA
    Early Interv Psychiatry 4:220-6. 2010
  10. ncbi request reprint P50 suppression in individuals at risk for schizophrenia: the convergence of clinical, familial, and vulnerability marker risk assessment
    Kristin S Cadenhead
    Department of Psychiatry, University of California San Diego, La Jolla, California 92093 0810, USA
    Biol Psychiatry 57:1504-9. 2005

Research Grants

  1. VULNERABILITY MARKERS IN PRODROMAL SCHIZOPHRENIA
    Kristin Cadenhead; Fiscal Year: 2001
  2. VULNERABILITY MARKERS IN PRODROMAL SCHIZOPHRENIA
    Kristin Cadenhead; Fiscal Year: 2009
  3. Vulnerability Markers in the Prodrome and First Episode of Schizophrenia
    Kristin Cadenhead; Fiscal Year: 2007
  4. VULNERABILITY MARKERS IN PRODROMAL SCHIZOPHRENIA
    Kristin Cadenhead; Fiscal Year: 2007
  5. VULNERABILITY MARKERS IN PRODROMAL SCHIZOPHRENIA
    Kristin Cadenhead; Fiscal Year: 2006
  6. VULNERABILITY MARKERS IN PRODROMAL SCHIZOPHRENIA
    Kristin Cadenhead; Fiscal Year: 2004
  7. VULNERABILITY MARKERS IN PRODROMAL SCHIZOPHRENIA
    Kristin Cadenhead; Fiscal Year: 2003
  8. VULNERABILITY MARKERS IN PRODROMAL SCHIZOPHRENIA
    Kristin Cadenhead; Fiscal Year: 2002
  9. VULNERABILITY MARKERS IN PRODROMAL SCHIZOPHRENIA
    Kristin S Cadenhead; Fiscal Year: 2010

Detail Information

Publications33

  1. ncbi request reprint Between-site reliability of startle prepulse inhibition across two early psychosis consortia
    Kristin S Cadenhead
    Department of Psychiatry, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0810, USA
    Neuroreport 24:626-30. 2013
    ..In planning multisite studies, it is essential to institute quality assurance procedures early and establish between-site reliability to assure comparable data across sites. ..
  2. ncbi request reprint Ethical implications for clinical practice and future research in "at risk" individuals
    Fiza Singh
    Department of Psychiatry, University of California San Diego, San Diego, California 92093 0810, USA
    Curr Pharm Des 18:606-12. 2012
    ..Thus it may be prudent to engage at risk populations early and to use broad-spectrum treatments with low risk benefit ratios to relieve functional impairments, while simultaneously studying all subsets of the at risk population...
  3. ncbi request reprint Cognitive functions in schizotypal personality disorder
    K S Cadenhead
    Department of Psychiatry, University of California, San Diego, La Jolla 92093 0804, USA
    Schizophr Res 37:123-32. 1999
    ..Schizotypal personality disordered (SPD) subjects do not have many of the confounds seen in schizophrenic patients, but may have the same pattern of cognitive deficits in attention and executive functioning...
  4. ncbi request reprint Sensory gating deficits assessed by the P50 event-related potential in subjects with schizotypal personality disorder
    K S Cadenhead
    Department of Psychiatry, University of California, San Diego 92093 0804, USA
    Am J Psychiatry 157:55-9. 2000
    ..Although schizotypal subjects have been shown to have deficits in sensorimotor gating as measured by prepulse inhibition, to the authors' knowledge P50 sensory gating in schizotypal personality disorder has yet to be reported...
  5. ncbi request reprint Modulation of the startle response and startle laterality in relatives of schizophrenic patients and in subjects with schizotypal personality disorder: evidence of inhibitory deficits
    K S Cadenhead
    Department of Psychiatry, University of California, San Diego, La Jolla, 92093 0804, USA
    Am J Psychiatry 157:1660-8. 2000
    ..The authors hypothesized that nonschizophrenic relatives of patients with schizophrenia would also have prepulse inhibition deficits, thereby reflecting a genetically transmitted susceptibility to sensorimotor gating deficits...
  6. pmc Startle reactivity and prepulse inhibition in prodromal and early psychosis: effects of age, antipsychotics, tobacco and cannabis in a vulnerable population
    Kristin S Cadenhead
    Department of Psychiatry, 0810, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0810, USA
    Psychiatry Res 188:208-16. 2011
    ....
  7. ncbi request reprint Neurobiological measures of schizotypal personality disorder: defining an inhibitory endophenotype?
    Kristin S Cadenhead
    Department of Psychiatry, University of California, San Diego, La Jolla, 92093 0810, USA
    Am J Psychiatry 159:869-71. 2002
    ....
  8. ncbi request reprint Vulnerability markers in the schizophrenia spectrum: implications for phenomenology, genetics, and the identification of the schizophrenia prodrome
    Kristin S Cadenhead
    Department of Psychiatry, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0810, USA
    Psychiatr Clin North Am 25:837-53. 2002
    ..Finally, genetic studies have yet to be performed in SPD...
  9. pmc Treatment history in the psychosis prodrome: characteristics of the North American Prodrome Longitudinal Study Cohort
    Kristin S Cadenhead
    Department of Psychiatry and Biobehavioral Sciences, UCSD, San Diego, California 92093 0810, USA
    Early Interv Psychiatry 4:220-6. 2010
    ..The primary aim of this manuscript is to describe the treatment histories of a large cohort of individuals who entered into one of seven prodromal research programs in a North American Prodrome Longitudinal Study consortium...
  10. ncbi request reprint P50 suppression in individuals at risk for schizophrenia: the convergence of clinical, familial, and vulnerability marker risk assessment
    Kristin S Cadenhead
    Department of Psychiatry, University of California San Diego, La Jolla, California 92093 0810, USA
    Biol Psychiatry 57:1504-9. 2005
    ..The aim of the present study was to determine whether individuals "at risk" for schizophrenia have deficits in P50 suppression, a preattentive measure of sensory gating...
  11. ncbi request reprint Visual information processing dysfunction across the developmental course of early psychosis
    V B Perez
    University of California, San Francisco UCSF, CA, USA
    Psychol Med 42:2167-79. 2012
    ..It has been suggested that VM impairments may be a vulnerability marker in individuals at risk for developing psychosis...
  12. ncbi request reprint Impact of prepulse characteristics on the detection of sensorimotor gating deficits in schizophrenia
    D L Braff
    Department of Psychiatry, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0804, USA
    Schizophr Res 49:171-8. 2001
    ....
  13. ncbi request reprint Endophenotyping schizotypy: a prelude to genetic studies within the schizophrenia spectrum
    Kristin S Cadenhead
    Department of Psychiatry, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0804, USA
    Schizophr Res 54:47-57. 2002
    ..Composite phenotypes can also be developed, which increase the probability of identifying the complex genetic architecture of schizophrenia spectrum disorders, which interact with nongenetic protective and exacerbating factors...
  14. pmc Validity of the prodromal risk syndrome for first psychosis: findings from the North American Prodrome Longitudinal Study
    Scott W Woods
    PRIME Prodromal Research Clinic, Department of Psychiatry, Yale University School of Medicine, 34 Park Street, New Haven, CT 06519, USA
    Schizophr Bull 35:894-908. 2009
    ..The strong evidence of diagnostic validity for the prodromal risk syndrome for first psychosis raises the question of its evaluation for inclusion in Diagnostic and Statistical Manual of Mental Disorders (Fifth Edition)...
  15. pmc Abnormal auditory N100 amplitude: a heritable endophenotype in first-degree relatives of schizophrenia probands
    Bruce I Turetsky
    Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Biol Psychiatry 64:1051-9. 2008
    ..We report initial results from the COGS dataset of auditory N100 amplitude and gating as candidate endophenotypes...
  16. pmc Course of neurocognitive deficits in the prodrome and first episode of schizophrenia
    Carol Jahshan
    Joint Doctoral Program in Clinical Psychology, San Diego State University University of California, San Diego, USA
    Neuropsychology 24:109-20. 2010
    ....
  17. pmc Neuropsychology of the prodrome to psychosis in the NAPLS consortium: relationship to family history and conversion to psychosis
    Larry J Seidman
    Department of Psychiatry, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Arch Gen Psychiatry 67:578-88. 2010
    ..Early detection and prospective evaluation of clinical high-risk (CHR) individuals who may develop schizophrenia or other psychotic disorders is critical for predicting psychosis onset and for testing preventive interventions...
  18. ncbi request reprint Information processing deficits of schizophrenia patients: relationship to clinical ratings, gender and medication status
    K S Cadenhead
    Department of Psychiatry, University of California, San Diego, La Jolla 92093 0804, USA
    Schizophr Res 28:51-62. 1997
    ..It is possible that VBM and RT share overlapping or interacting neural substrates...
  19. pmc Inhibition of the P50 cerebral evoked response to repeated auditory stimuli: results from the Consortium on Genetics of Schizophrenia
    Ann Olincy
    Department of Psychiatry, Veterans Affairs Denver Medical Center VISN 19 MIRECC, CO 80045, USA
    Schizophr Res 119:175-82. 2010
    ....
  20. ncbi request reprint Startle gating deficits in a large cohort of patients with schizophrenia: relationship to medications, symptoms, neurocognition, and level of function
    Neal R Swerdlow
    Departments of Psychiatry, School of Medicine, University of California San Diego, La Jolla, CA 92093, USA
    Arch Gen Psychiatry 63:1325-35. 2006
    ..Patients with schizophrenia exhibit deficits in automatic, preattentive sensorimotor gating (prepulse inhibition [PPI]) of the startle reflex...
  21. ncbi request reprint Prepulse inhibition and habituation of the startle response are stable neurobiological measures in a normal male population
    K S Cadenhead
    Department of Psychiatry, University of California, San Diego, La Jolla 92093 0804, USA
    Biol Psychiatry 45:360-4. 1999
    ..These data support the hypothesis that PPI and habituation are relatively stable neurobiological markers...
  22. pmc Social functioning in young people at risk for schizophrenia
    Jacob S Ballon
    University of California, San Diego, Department of Psychiatry, San Diego, CA 92093 0810, USA
    Psychiatry Res 151:29-35. 2007
    ..Individuals at risk for schizophrenia have significant functional deficits which may be potential indicators of increased vulnerability for psychosis...
  23. pmc Verbal working memory impairments in individuals with schizophrenia and their first-degree relatives: findings from the Consortium on the Genetics of Schizophrenia
    William P Horan
    Department of Psychiatry and Biobehavioral Sciences, Geffen School of Medicine at University of California Los Angeles, Los Angeles, California 90095 6968, USA
    Schizophr Res 103:218-28. 2008
    ....
  24. pmc Cannabis abuse and risk for psychosis in a prodromal sample
    Karin Kristensen
    Department of Psychiatry, 0810, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0810, USA
    Psychiatry Res 151:151-4. 2007
    ....
  25. ncbi request reprint How does studying schizotypal personality disorder inform us about the prodrome of schizophrenia?
    Katherine Seeber
    Department of Psychiatry, 0810, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
    Curr Psychiatry Rep 7:41-50. 2005
    ..The current review details a strategy for researching the schizophrenia prodrome by using information gained from research in schizotypal personality disorder...
  26. ncbi request reprint The relationship of information-processing deficits and clinical symptoms in schizotypal personality disorder
    K S Cadenhead
    Department of Psychiatry, University of California, San Diego, La Jolla 92093 0804, USA
    Biol Psychiatry 40:853-8. 1996
    ..These findings suggest an important relationship between symptoms of SPD and neurophysiologic deficits...
  27. ncbi request reprint Initial heritability analyses of endophenotypic measures for schizophrenia: the consortium on the genetics of schizophrenia
    Tiffany A Greenwood
    Department of Psychiatry, University of California San Diego, La Jolla, USA
    Arch Gen Psychiatry 64:1242-50. 2007
    ..Exploration of the genetic architecture of specific endophenotypes may be a powerful strategy for understanding the genetic basis of schizophrenia...
  28. pmc Obstetrical complications in people at risk for developing schizophrenia
    Jacob S Ballon
    Department of Psychiatry, 0810, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0810, United States
    Schizophr Res 98:307-11. 2008
    ..Obstetrical complications may be an important risk factor in identifying vulnerable subjects and ultimately may, along with other risk factors, be part of an algorithm for determining likelihood of developing schizophrenia...
  29. pmc The Consortium on the Genetics of Endophenotypes in Schizophrenia: model recruitment, assessment, and endophenotyping methods for a multisite collaboration
    Monica E Calkins
    Neuropsychiatry Section, Department of Psychiatry, University of Pennsylvania, 10 Gates, 3400 Spruce St, Philadelphia, PA 19104, USA
    Schizophr Bull 33:33-48. 2007
    ..The purpose of this article is to provide a description of the COGS structure and methods, including participant recruitment and assessment...
  30. pmc Risk and protection in prodromal schizophrenia: ethical implications for clinical practice and future research
    Nasra Haroun
    University of California, San Diego, USA
    Schizophr Bull 32:166-78. 2006
    ..Finally, our data strengthen the evidence base available to inform the discussion of ethical issues relevant to this important research area...
  31. ncbi request reprint Successful multi-site measurement of antisaccade performance deficits in schizophrenia
    Allen D Radant
    Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, Washington, United States
    Schizophr Res 89:320-9. 2007
    ..These results confirm previous findings of antisaccade deficits in schizophrenia subjects and support the use of the antisaccade task as a potential schizophrenia endophenotype in multi-site genetic studies...
  32. pmc North American Prodrome Longitudinal Study: a collaborative multisite approach to prodromal schizophrenia research
    Jean Addington
    Centre for Addiction and Mental Health, 250 College Street, Toronto, Ontario, M5T 1R8, Canada
    Schizophr Bull 33:665-72. 2007
    ....

Research Grants12

  1. VULNERABILITY MARKERS IN PRODROMAL SCHIZOPHRENIA
    Kristin Cadenhead; Fiscal Year: 2001
    ..The disruption of social networks, education and occupational activity as well as the high incidence of suicide and crime that often accompany psychosis might be reduced or averted. ..
  2. VULNERABILITY MARKERS IN PRODROMAL SCHIZOPHRENIA
    Kristin Cadenhead; Fiscal Year: 2009
    ..The disruption of social networks, education and occupational activity and the high incidence of suicide and crime that often accompany psychosis might be reduced or averted. ..
  3. Vulnerability Markers in the Prodrome and First Episode of Schizophrenia
    Kristin Cadenhead; Fiscal Year: 2007
    ....
  4. VULNERABILITY MARKERS IN PRODROMAL SCHIZOPHRENIA
    Kristin Cadenhead; Fiscal Year: 2007
    ..The disruption of social networks, education and occupational activity and the high incidence of suicide and crime that often accompany psychosis might be reduced or averted. ..
  5. VULNERABILITY MARKERS IN PRODROMAL SCHIZOPHRENIA
    Kristin Cadenhead; Fiscal Year: 2006
    ..The disruption of social networks, education and occupational activity and the high incidence of suicide and crime that often accompany psychosis might be reduced or averted. ..
  6. VULNERABILITY MARKERS IN PRODROMAL SCHIZOPHRENIA
    Kristin Cadenhead; Fiscal Year: 2004
    ..The disruption of social networks, education and occupational activity as well as the high incidence of suicide and crime that often accompany psychosis might be reduced or averted. ..
  7. VULNERABILITY MARKERS IN PRODROMAL SCHIZOPHRENIA
    Kristin Cadenhead; Fiscal Year: 2003
    ..The disruption of social networks, education and occupational activity as well as the high incidence of suicide and crime that often accompany psychosis might be reduced or averted. ..
  8. VULNERABILITY MARKERS IN PRODROMAL SCHIZOPHRENIA
    Kristin Cadenhead; Fiscal Year: 2002
    ..The disruption of social networks, education and occupational activity as well as the high incidence of suicide and crime that often accompany psychosis might be reduced or averted. ..
  9. VULNERABILITY MARKERS IN PRODROMAL SCHIZOPHRENIA
    Kristin S Cadenhead; Fiscal Year: 2010
    ..The disruption of social networks, education and occupational activity and the high incidence of suicide and crime that often accompany psychosis might be reduced or averted. ..