E Cadenas

Summary

Affiliation: University of Southern California
Country: USA

Publications

  1. ncbi request reprint Mitochondrial free radical generation, oxidative stress, and aging
    E Cadenas
    Department of Molecular Pharmacology and Toxicology, School of Pharmacy University of Southern California, Los Angeles 90033, USA
    Free Radic Biol Med 29:222-30. 2000
  2. ncbi request reprint Cellular titration of apoptosis with steady state concentrations of H(2)O(2): submicromolar levels of H(2)O(2) induce apoptosis through Fenton chemistry independent of the cellular thiol state
    F Antunes
    Department of Molecular Pharmacology and Toxicology, School of Pharmacy, University of Southern California, Los Angeles, CA, USA
    Free Radic Biol Med 30:1008-18. 2001
  3. ncbi request reprint Estimation of H2O2 gradients across biomembranes
    F Antunes
    Department of Molecular Pharmacology and Toxicology, School of Pharmacy, University of Southern California, Los Angeles 90089 9121, USA
    FEBS Lett 475:121-6. 2000
  4. pmc Hemodynamics influences vascular peroxynitrite formation: Implication for low-density lipoprotein apo-B-100 nitration
    Tzung K Hsiai
    Department of Biomedical Engineering and Cardiovascular Medicine, University of Southern California, Los Angeles, CA 90081, USA
    Free Radic Biol Med 42:519-29. 2007
  5. ncbi request reprint Mitochondrial free radical production and cell signaling
    Enrique Cadenas
    Department of Molecular Pharmacology and Toxicology, School of Pharmacy, University of Southern California, PSC 622, 1985 Zonal Avenue, Los Angeles, CA 90033, USA
    Mol Aspects Med 25:17-26. 2004
  6. pmc Apoptosis induced by exposure to a low steady-state concentration of H2O2 is a consequence of lysosomal rupture
    F Antunes
    Department of Molecular Pharmacology and Toxicology, School of Pharmacy, University of Southern California, 1985 Zonal Ave, PSC 622, Los Angeles, CA 90089 9121, USA
    Biochem J 356:549-55. 2001
  7. ncbi request reprint Pathways of dopamine oxidation mediated by nitric oxide
    Daniel Rettori
    Department of Molecular Pharmacology and Toxicology, School of Pharmacy, University of Southern California, Los Angeles, CA 90033, USA
    Free Radic Biol Med 33:685-90. 2002
  8. ncbi request reprint Mitochondrial damage by nitric oxide is potentiated by dopamine in PC12 cells
    Fernando Antunes
    Department of Molecular Pharmacology and Toxicology, School of Pharmacy, University of Southern California, Los Angeles, CA 90089 9121, USA
    Biochim Biophys Acta 1556:233-8. 2002
  9. ncbi request reprint Mitochondrial superoxide anion production and release into intermembrane space
    Derick Han
    Department of Molecular Pharmacology and Toxicology, School of Pharmacy, University of Southern California, Los Angeles, California 90033, USA
    Methods Enzymol 349:271-80. 2002
  10. ncbi request reprint c-Jun N-terminal kinase regulates mitochondrial bioenergetics by modulating pyruvate dehydrogenase activity in primary cortical neurons
    Qiongqiong Zhou
    Department of Molecular Pharmacology and Toxicology, School of Pharmacy, University of Southern California, Los Angeles, California 90089 9121, USA
    J Neurochem 104:325-35. 2008

Collaborators

Detail Information

Publications34

  1. ncbi request reprint Mitochondrial free radical generation, oxidative stress, and aging
    E Cadenas
    Department of Molecular Pharmacology and Toxicology, School of Pharmacy University of Southern California, Los Angeles 90033, USA
    Free Radic Biol Med 29:222-30. 2000
    ..The possible contributions of mitochondrial oxidative polynucleotide and protein turnover to apoptosis and aging are explored...
  2. ncbi request reprint Cellular titration of apoptosis with steady state concentrations of H(2)O(2): submicromolar levels of H(2)O(2) induce apoptosis through Fenton chemistry independent of the cellular thiol state
    F Antunes
    Department of Molecular Pharmacology and Toxicology, School of Pharmacy, University of Southern California, Los Angeles, CA, USA
    Free Radic Biol Med 30:1008-18. 2001
    ....
  3. ncbi request reprint Estimation of H2O2 gradients across biomembranes
    F Antunes
    Department of Molecular Pharmacology and Toxicology, School of Pharmacy, University of Southern California, Los Angeles 90089 9121, USA
    FEBS Lett 475:121-6. 2000
    ..The procedure presented in this work can easily be applied to other cell lines and provides a quantitative framework to interpret the data obtained when cells are exposed to an external source of H2O2...
  4. pmc Hemodynamics influences vascular peroxynitrite formation: Implication for low-density lipoprotein apo-B-100 nitration
    Tzung K Hsiai
    Department of Biomedical Engineering and Cardiovascular Medicine, University of Southern California, Los Angeles, CA 90081, USA
    Free Radic Biol Med 42:519-29. 2007
    ..Hence, the characteristics of shear stress in the arterial bifurcations influenced the relative production of O2(-.) and .NO with an implication for ONOO(-) formation as evidenced by LDL protein nitration...
  5. ncbi request reprint Mitochondrial free radical production and cell signaling
    Enrique Cadenas
    Department of Molecular Pharmacology and Toxicology, School of Pharmacy, University of Southern California, PSC 622, 1985 Zonal Avenue, Los Angeles, CA 90033, USA
    Mol Aspects Med 25:17-26. 2004
    ....
  6. pmc Apoptosis induced by exposure to a low steady-state concentration of H2O2 is a consequence of lysosomal rupture
    F Antunes
    Department of Molecular Pharmacology and Toxicology, School of Pharmacy, University of Southern California, 1985 Zonal Ave, PSC 622, Los Angeles, CA 90089 9121, USA
    Biochem J 356:549-55. 2001
    ....
  7. ncbi request reprint Pathways of dopamine oxidation mediated by nitric oxide
    Daniel Rettori
    Department of Molecular Pharmacology and Toxicology, School of Pharmacy, University of Southern California, Los Angeles, CA 90033, USA
    Free Radic Biol Med 33:685-90. 2002
    ..A mechanism is presented that considers the several factors influencing these reactions...
  8. ncbi request reprint Mitochondrial damage by nitric oxide is potentiated by dopamine in PC12 cells
    Fernando Antunes
    Department of Molecular Pharmacology and Toxicology, School of Pharmacy, University of Southern California, Los Angeles, CA 90089 9121, USA
    Biochim Biophys Acta 1556:233-8. 2002
    ..Dopamine stored in dopaminergic cells may cause these cells to be more susceptible to the deleterious effects of *NO, which involve irreversible impairment of mitochondrial respiration...
  9. ncbi request reprint Mitochondrial superoxide anion production and release into intermembrane space
    Derick Han
    Department of Molecular Pharmacology and Toxicology, School of Pharmacy, University of Southern California, Los Angeles, California 90033, USA
    Methods Enzymol 349:271-80. 2002
    ..This, together with the putative occurrence of a Cu, Zn-superoxide dismutase in this compartment may account for part of H2O2 released by mitochondria and contributing to a cytosolic steady-state level of this species in cytosol...
  10. ncbi request reprint c-Jun N-terminal kinase regulates mitochondrial bioenergetics by modulating pyruvate dehydrogenase activity in primary cortical neurons
    Qiongqiong Zhou
    Department of Molecular Pharmacology and Toxicology, School of Pharmacy, University of Southern California, Los Angeles, California 90089 9121, USA
    J Neurochem 104:325-35. 2008
    ..These results suggest that JNK mediates a signaling pathway that regulates metabolic functions in mitochondria as part of a network that coordinates cytosolic and mitochondrial processes relevant for cell function...
  11. ncbi request reprint Nitric oxide and cell signaling pathways in mitochondrial-dependent apoptosis
    Clinton S Boyd
    Department of Molecular Pharmacology and Toxicology, School of Pharmacy, University of Southern California, Los Angeles 90089 9121, USA
    Biol Chem 383:411-23. 2002
    ....
  12. pmc c-Jun N-terminal kinase (JNK)-mediated modulation of brain mitochondria function: new target proteins for JNK signalling in mitochondrion-dependent apoptosis
    Hagen Schroeter
    Department of Molecular Pharmacology and Toxicology, School of Pharmacy, University of Southern California, 1985 Zonal Avenue, Los Angeles 90089 9121, USA
    Biochem J 372:359-69. 2003
    ..Taken together, JNK-dependent phosphorylation of mitochondrial proteins including, but not limited to, Bcl-2/Bcl-x(L) may represent a potential of the modulation of mitochondrial function during apoptosis...
  13. ncbi request reprint Relative contributions of heart mitochondria glutathione peroxidase and catalase to H(2)O(2) detoxification in in vivo conditions
    Fernando Antunes
    Department of Molecular Pharmacology and Toxicology, School of Pharmacy, University of Southern California, Los Angeles, USA
    Free Radic Biol Med 33:1260-7. 2002
    ..It is suggested that the physiological role of the low amounts of catalase found in heart mitochondria is related to its peroxidatic rather than catalatic activity...
  14. ncbi request reprint The reaction of nitric oxide with 6-hydroxydopamine: implications for Parkinson's disease
    Natalia A Riobo
    Laboratory of Oxygen Metabolism, University Hospital, School of Medicine, University of Buenos Aires, Buenos Aires, Argentina
    Free Radic Biol Med 32:115-21. 2002
    ..The implications of this reaction for in vivo models are discussed in terms of the generation of reactive nitrogen and oxygen species within a propagation process that may play a significant role in neurodegenerative diseases...
  15. pmc Progesterone and estrogen regulate oxidative metabolism in brain mitochondria
    Ronald W Irwin
    Department of Pharmacology and Pharmaceutical Sciences, University of Southern California, Pharmaceutical Sciences Center, 1985 Zonal Avenue, Los Angeles, California 90089, USA
    Endocrinology 149:3167-75. 2008
    ..As such, ovarian hormone replacement induces mitochondrial alterations in the central nervous system supporting efficient and balanced bioenergetics reducing oxidative stress and attenuating endogenous oxidative damage...
  16. ncbi request reprint The mechanism of cytochrome C oxidase inhibition by nitric oxide
    Fernando Antunes
    Grupo de Bioquímica dos Oxidantes e Antioxidantes, Centro de Quimica e Bioquimica, Lisboa, Portugal
    Front Biosci 12:975-85. 2007
    ..The physiological and pathological relevance of this inhibition is briefly discussed...
  17. pmc Mitochondrial respiratory chain and thioredoxin reductase regulate intermembrane Cu,Zn-superoxide dismutase activity: implications for mitochondrial energy metabolism and apoptosis
    Pedro Iñarrea
    Departamento de Bioquimica y Biologia Molecular y Celular, Facultad de Ciencias, Universidad de Zaragoza, 50009 Zaragoza, Spain
    Biochem J 405:173-9. 2007
    ..These findings suggest that H2O2, superoxide and TxrR-1 regulate IMS SOD1 activity reversibly, and that the active enzyme is implicated in protecting vital mitochondrial functions...
  18. ncbi request reprint On the biologic role of the reaction of NO with oxidized cytochrome c oxidase
    Fernando Antunes
    Grupo de Bioquímica dos Oxidantes e Antioxidantes, Centro de Química e Bioquímica and Departamento de Química e Bioquímica, Faculdade de Ciencias da Universidade de Lisboa, P 1250 047 Lisboa, Portugal
    Antioxid Redox Signal 9:1569-79. 2007
    ....
  19. ncbi request reprint Oxidants and antioxidants revisited. New concepts of oxidative stress
    Lester Packer
    Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, CA 90089, USA
    Free Radic Res 41:951-2. 2007
  20. doi request reprint Free radicals and exercise: an introduction
    Lester Packer
    Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, CA 90033, USA
    Free Radic Biol Med 44:123-5. 2008
  21. ncbi request reprint Hippocampal mitochondrial dysfunction in rat aging
    Ana Navarro
    Departamento de Bioquimica y Biologia Molecular, Facultad de Medicina, Plaza Fragela 9, 11003 Cadiz, Spain
    Am J Physiol Regul Integr Comp Physiol 294:R501-9. 2008
    ..A significant statistical correlation was observed between mitochondrial oxidative damage and enzymatic activity. Mitochondrial dysfunction with shortage of energy supply is considered a likely cause of dysfunction in aged hippocampus...
  22. ncbi request reprint Dietary thioproline decreases spontaneous food intake and increases survival and neurological function in mice
    Ana Navarro
    Department of Biochemistry and Molecular Biology, School of Medicine, University of Cadiz, Cadiz, Spain
    Antioxid Redox Signal 9:131-41. 2007
    ..It is surmised that thioproline induces an anorexic effect associated with improved survival and neurological function through a decreased oxidative damage and regulation that may involve hypothalamic appetite centers...
  23. pmc Concentration dynamics of nitric oxide in rat hippocampal subregions evoked by stimulation of the NMDA glutamate receptor
    Ana Ledo
    Faculty of Pharmacy, Center for Neurosciences and Cell Biology, University of Coimbra, 3000 Coimbra, Portugal
    Proc Natl Acad Sci U S A 102:17483-8. 2005
    ..These findings may be relevant for the understanding of the role of *NO in physiologic mechanisms in the hippocampus and the differential sensitivity of the hippocampal subregions to NMDA receptor-dependent neurodegeneration...
  24. ncbi request reprint Sites and mechanisms of aconitase inactivation by peroxynitrite: modulation by citrate and glutathione
    Derick Han
    Research Center for Liver Disease, Keck School of Medicine, University of Southern California, 2011 Zonal Avenue, Los Angeles, California 90089 9121, USA
    Biochemistry 44:11986-96. 2005
    ..The mechanisms inherent in aconitase inactivation by ONOO- are discussed in terms of the mitochondrial matrix metabolic and thiol redox state...
  25. ncbi request reprint Oxidation of DOPAC by nitric oxide: effect of superoxide dismutase
    João Laranjinha
    Faculty of Pharmacy and Center for Neurosciences, University of Coimbra, Couraça dos Apóstolos 51, R C, 3000 Coimbra, Portugal
    J Neurochem 81:892-900. 2002
    ..NO by the enzyme. The biological relevance of these reactions is also discussed in terms of the reactivity of peroxynitrite towards DOPAC as a model with implications for aerobic conditions...
  26. ncbi request reprint The modulation of mitochondrial nitric-oxide synthase activity in rat brain development
    Natalia A Riobo
    Laboratory of Oxygen Metabolism, University Hospital, Av Cordoba 2351, 1120 Buenos Aires, Argentina
    J Biol Chem 277:42447-55. 2002
    ..Altogether, these findings support the notion that a coordinated modulation of mtNOS and Mn-superoxide dismutase contributes to establish the rat brain redox status and participate in the normal physiology of brain development...
  27. ncbi request reprint MAPK signaling in neurodegeneration: influences of flavonoids and of nitric oxide
    Hagen Schroeter
    Antioxidant Research Group, Wolfson Centre for Age Related Diseases and Centre for Neuroscience Research, Guy s, King s and St Thomas s School of Biomedical Sciences, King s College, Guy s Campus, Hodgkin Bldg, 3rd Floor, London SE1 9RT, UK
    Neurobiol Aging 23:861-80. 2002
    ..This review addresses recent findings on the biological effects of flavonoids and nitric oxide in neurodegeneration and aims to elucidate the rationale for their prospective use as modulators of cellular signal transduction...
  28. ncbi request reprint Voltage-dependent anion channels control the release of the superoxide anion from mitochondria to cytosol
    Derick Han
    University of Southern California Research Center for Liver Disease, Keck School of Medicine, University of Southern California, Los Angeles, California 90089 9121, USA
    J Biol Chem 278:5557-63. 2003
    ..These findings are discussed in terms of competitive decay pathways for O(2)*- in the intermembrane space and cytosol as well as the implications of these processes for modulating cell signaling pathways in these compartments...
  29. ncbi request reprint Kinetic analysis of thapsigargin-induced thymocyte apoptosis
    Juanita Bustamante
    Laboratory of Free Radical Biology, School of Pharmacy and Biochemistry, University of Buenos Aires, Junin 956, C1113AAD, Buenos Aires, Argentina
    Free Radic Biol Med 37:1490-8. 2004
    ..Preincubation of thymocytes with NOS inhibitors (NG-methyl-L-arginine and L-Nomega-nitro-L-arginine methylester) halted the whole process through inhibition of mitochondrial and endoplasmic reticulum NOS activities and of DNA laddering...
  30. pmc Redox activation of mitochondrial intermembrane space Cu,Zn-superoxide dismutase
    Pedro Iñarrea
    Departamento de Bioquimica y Biologia Molecular y Celular, Facultad de Ciencias, Universidad de Zaragoza 50009 Zaragoza, Spain
    Biochem J 387:203-9. 2005
    ..These findings suggest that intermembrane space Cu,Zn-superoxide dismutase is inactive in intact mitochondria and that an oxidative modification of its critical thiol groups is necessary for its activation...
  31. pmc On the mechanism and biology of cytochrome oxidase inhibition by nitric oxide
    Fernando Antunes
    Grupo de Bioquímica dos Oxidantes e Antioxidantes, Centro de Quimica e Bioquimica, da Faculdade de Ciências da Universidade de Lisboa, P 1749 016 Lisbon, Portugal
    Proc Natl Acad Sci U S A 101:16774-9. 2004
    ..In pathological situations such as COX-deficiency diseases and chronic inflammation, an excessive inhibition of the mitochondrial respiration is predicted...
  32. ncbi request reprint Redox interactions of nitric oxide with dopamine and its derivatives
    Fernando Antunes
    Instituto de Investigação Científica Bento da Rocha Cabral and Grupo de Bioquimica dos Oxidantes e Antioxidantes, Centro de Quimica e Bioquimica, Universidade de Lisboa, Portugal
    Toxicology 208:207-12. 2005
    ..The physiological relevance of *NO-driven chemical modifications of dopamine and its derivatives and the ensuing free radical production are discussed in connection with the neurodegeneration inherent in Parkinson's disease...
  33. ncbi request reprint Mitochondrial nitric oxide synthase
    Pedram Ghafourifar
    Department of Pharmacology, Joan C Edwards School of Medicine, Marshall University, Huntington, WV 25704, USA
    Trends Pharmacol Sci 26:190-5. 2005
    ..In this article, we review the current understanding of the roles of mtNOS as a crucial biochemical regulator of mitochondrial functions and attempt to reconcile apparent discrepancies in the literature on mtNOS...
  34. pmc Tumor cell phenotype is sustained by selective MAPK oxidation in mitochondria
    Soledad Galli
    Laboratory of Oxygen Metabolism, University Hospital, University of Buenos Aires, Buenos Aires, Argentina
    PLoS ONE 3:e2379. 2008
    ..Considering that tumor mitochondria are dysfunctional, their inability to increase H(2)O(2) yield should disrupt synchronized MAPK oxidations and the regulation of cell cycle leading cells to remain in a proliferating phenotype...