Pedro Cabrales

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Perfluorocarbon in microcirculation during ischemia reperfusion
    Pedro Cabrales
    La Jolla Bioengineering Institute, La Jolla, CA Department of Bioengineering, University of California, San Diego, La Jolla, CA, USA
    J Am Coll Surg 204:225-35. 2007
  2. pmc Balance between vasoconstriction and enhanced oxygen delivery
    Pedro Cabrales
    La Jolla Bioengineering Institute, Department of Bioengineering, University of California, San Diego, La Jolla, California 92037, USA
    Transfusion 48:2087-95. 2008
  3. pmc Dissociation of local nitric oxide concentration and vasoconstriction in the presence of cell-free hemoglobin oxygen carriers
    Amy G Tsai
    Department of Bioengineering, University of California, San Diego, La Jolla, CA 92093 0412, USA
    Blood 108:3603-10. 2006
  4. ncbi request reprint Deferoxamine lowers tissue damage after 80% exchange transfusion with polymerized hemoglobin
    Pedro Cabrales
    La Jolla Bioengineering Institute, La Jolla, California 92037, USA
    Antioxid Redox Signal 9:375-84. 2007
  5. ncbi request reprint Hemodynamics and tissue oxygenation after hemodilution with ultrahigh molecular weight polymerized albumin
    C Castro
    Department of Bioengineering, University of California, San Diego, La Jolla, CA, USA
    Minerva Anestesiol 80:537-46. 2014
  6. pmc Nonobese, exercising children diagnosed with dyslipidemia have normal C-reactive protein
    Miguel Arturo Salazar Vázquez
    Facultad de Ciencias Químicas Gómez Palacio, Universidad Juarez del Estado de Durango, Dgo, Mexico
    Vasc Health Risk Manag 5:65-9; quiz 70-2. 2009
  7. pmc Blood substitutes: evolution from noncarrying to oxygen- and gas-carrying fluids
    Pedro Cabrales
    Department of Bioengineering, University of California, San Diego, La Jolla, California 92093 0412, USA
    ASAIO J 59:337-54. 2013
  8. pmc HBOC vasoactivity: interplay between nitric oxide scavenging and capacity to generate bioactive nitric oxide species
    Pedro Cabrales
    Department of Bioengineering, University of California, San Diego, CA, USA
    Antioxid Redox Signal 18:2284-97. 2013
  9. ncbi request reprint Hemoglobin encapsulated poly(ethylene glycol) surface conjugated vesicles attenuate vasoactivity of cell-free hemoglobin
    Pedro Cabrales
    Department of Bioengineering, University of California San Diego, 9500 Gilman Dr, La Jolla, CA 92093 0412, USA
    Curr Drug Discov Technol 9:224-34. 2012
  10. pmc Modulation of perfusion and oxygenation by red blood cell oxygen affinity during acute anemia
    Pedro Cabrales
    La Jolla Bioengineering Institute, 505 Coast Boulevard South, Suite 405, La Jolla, CA 92037, USA
    Am J Respir Cell Mol Biol 38:354-61. 2008

Collaborators

Detail Information

Publications88

  1. ncbi request reprint Perfluorocarbon in microcirculation during ischemia reperfusion
    Pedro Cabrales
    La Jolla Bioengineering Institute, La Jolla, CA Department of Bioengineering, University of California, San Diego, La Jolla, CA, USA
    J Am Coll Surg 204:225-35. 2007
    ....
  2. pmc Balance between vasoconstriction and enhanced oxygen delivery
    Pedro Cabrales
    La Jolla Bioengineering Institute, Department of Bioengineering, University of California, San Diego, La Jolla, California 92037, USA
    Transfusion 48:2087-95. 2008
    ..Responses to facilitated O(2) transport, after exchange transfusion with PBH, were studied in the hamster window chamber model during acute extreme anemia to determine how PBH affects microvascular perfusion and tissue oxygenation...
  3. pmc Dissociation of local nitric oxide concentration and vasoconstriction in the presence of cell-free hemoglobin oxygen carriers
    Amy G Tsai
    Department of Bioengineering, University of California, San Diego, La Jolla, CA 92093 0412, USA
    Blood 108:3603-10. 2006
    ....
  4. ncbi request reprint Deferoxamine lowers tissue damage after 80% exchange transfusion with polymerized hemoglobin
    Pedro Cabrales
    La Jolla Bioengineering Institute, La Jolla, California 92037, USA
    Antioxid Redox Signal 9:375-84. 2007
    ..Assessment of tissue viability after exchange suggests that chelation treatment in cases of large exchange transfusions with acellular Hb could be potentially beneficial...
  5. ncbi request reprint Hemodynamics and tissue oxygenation after hemodilution with ultrahigh molecular weight polymerized albumin
    C Castro
    Department of Bioengineering, University of California, San Diego, La Jolla, CA, USA
    Minerva Anestesiol 80:537-46. 2014
    ..Therefore, polymerization of human serum albumin (HSA) presents a simple strategy to increase HSA's molecular size...
  6. pmc Nonobese, exercising children diagnosed with dyslipidemia have normal C-reactive protein
    Miguel Arturo Salazar Vázquez
    Facultad de Ciencias Químicas Gómez Palacio, Universidad Juarez del Estado de Durango, Dgo, Mexico
    Vasc Health Risk Manag 5:65-9; quiz 70-2. 2009
    ..Exercise is associated with the release of antiinflammatory cytokines, therefore our results support the contention that it is a significant factor in promoting health conditions from an early stage in life...
  7. pmc Blood substitutes: evolution from noncarrying to oxygen- and gas-carrying fluids
    Pedro Cabrales
    Department of Bioengineering, University of California, San Diego, La Jolla, California 92093 0412, USA
    ASAIO J 59:337-54. 2013
    ..Conversely, full, blood-like O2-carrying capacity reestablishment awaits the control of O2 carrier toxicity. ..
  8. pmc HBOC vasoactivity: interplay between nitric oxide scavenging and capacity to generate bioactive nitric oxide species
    Pedro Cabrales
    Department of Bioengineering, University of California, San Diego, CA, USA
    Antioxid Redox Signal 18:2284-97. 2013
    ..Specifically, it is important to reconcile the different hypotheses of Hb toxicity, such as nitric oxide (NO) depletion and oxidative reactions, to provide a coherent molecular basis for designing a safe HBOC...
  9. ncbi request reprint Hemoglobin encapsulated poly(ethylene glycol) surface conjugated vesicles attenuate vasoactivity of cell-free hemoglobin
    Pedro Cabrales
    Department of Bioengineering, University of California San Diego, 9500 Gilman Dr, La Jolla, CA 92093 0412, USA
    Curr Drug Discov Technol 9:224-34. 2012
    ..Significance: Vesicles containing Hb can be used as a new therapeutic agent in transfusion medicine to treat anemia and revert hypoperfusion...
  10. pmc Modulation of perfusion and oxygenation by red blood cell oxygen affinity during acute anemia
    Pedro Cabrales
    La Jolla Bioengineering Institute, 505 Coast Boulevard South, Suite 405, La Jolla, CA 92037, USA
    Am J Respir Cell Mol Biol 38:354-61. 2008
    ..Erythrocytes with increased Hb-O(2) affinity maintained hemodynamic conditions, Do(2) and decreased tissue Po(2). This study shows that in an anemic condition, maximal tissue Po(2) does not correspond to maximal Do(2) and Vo(2)...
  11. ncbi request reprint Resuscitation from hemorrhagic shock with hydroxyethyl starch and coagulation changes
    Pedro Cabrales
    La Jolla Bioengineering Institute, La Jolla, California 92037, USA
    Shock 28:461-7. 2007
    ..The HES MW does not seem to be a factor in compromising platelet adherence on stimulated endothelium. The longer initial intravascular persistence of H-HES might result in longer-lasting volume effects...
  12. pmc Transfusion restores blood viscosity and reinstates microvascular conditions from hemorrhagic shock independent of oxygen carrying capacity
    Pedro Cabrales
    La Jolla Bioengineering Institute, La Jolla, CA 92037, USA
    Resuscitation 75:124-34. 2007
    ....
  13. ncbi request reprint Effects of erythrocyte flexibility on microvascular perfusion and oxygenation during acute anemia
    Pedro Cabrales
    La Jolla Bioengineering Institute, 505 Coast Boulevard South Suite 405, La Jolla, CA 92037, USA
    Am J Physiol Heart Circ Physiol 293:H1206-15. 2007
    ....
  14. ncbi request reprint Is resuscitation from hemorrhagic shock limited by blood oxygen-carrying capacity or blood viscosity?
    Pedro Cabrales
    La Jolla Bioengineering Institute, La Jolla, California 92037, USA
    Shock 27:380-9. 2007
    ..Conversely, the restoration of blood rheological properties improves resuscitation independently of the restitution of oxygen-carrying capacity...
  15. ncbi request reprint Microvascular and capillary perfusion following glycocalyx degradation
    Pedro Cabrales
    La Jolla Bioengineering Institute, 505 Coast Boulevard South, La Jolla, CA 92037, USA
    J Appl Physiol (1985) 102:2251-9. 2007
    ..These findings suggest that the decrease in the glycocalyx leads to capillary perfusion impairments...
  16. ncbi request reprint Hemorrhagic shock resuscitation with carbon monoxide saturated blood
    Pedro Cabrales
    La Jolla Bioengineering Institute, 505 Coast Boulevard South, La Jolla, CA 92037, USA
    Resuscitation 72:306-18. 2007
    ..The precise cellular mechanisms involved require further elucidation. CO is a novel experimental strategy to improve tissue viability and requires the appropriated preclinical studies to confirm its efficacy...
  17. ncbi request reprint Plasma viscosity regulates systemic and microvascular perfusion during acute extreme anemic conditions
    Pedro Cabrales
    La Jolla Bioengineering Institute, 505 Coast Blvd South, La Jolla, CA 92037, USA
    Am J Physiol Heart Circ Physiol 291:H2445-52. 2006
    ..Microhemodynamic data corresponded to microsphere-measured perfusion data in vital organs...
  18. ncbi request reprint Blood viscosity maintains microvascular conditions during normovolemic anemia independent of blood oxygen-carrying capacity
    Pedro Cabrales
    La Jolla Bioengineering Institute, La Jolla, CA, USA
    Am J Physiol Heart Circ Physiol 291:H581-90. 2006
    ..Thus the fall in systemic and microvascular conditions during extreme hemodilution with low-viscosity plasma expanders seems to be, in part, from the decrease in blood viscosity independent of the reduction in oxygen content...
  19. pmc Increased plasma viscosity prolongs microhemodynamic conditions during small volume resuscitation from hemorrhagic shock
    Pedro Cabrales
    La Jolla Bioengineering Institute, La Jolla, CA 92037, USA
    Resuscitation 77:379-86. 2008
    ..These results suggest the importance of restoration of blood rheological properties through enhancing plasma viscosity, influencing the re-establishment of microvascular perfusion during small volume resuscitation from hemorrhagic shock...
  20. pmc Volume resuscitation from hemorrhagic shock with albumin and hexaPEGylated human serum albumin
    Pedro Cabrales
    La Jolla Bioengineering Institute, La Jolla, CA 92037, USA
    Resuscitation 79:139-46. 2008
    ..Only recovery with PEG-Alb was sustained beyond 90 min. Hemodynamic functional benefits of PEG-Alb and the potential disadvantages associated with HSA, suggest PEG-Alb as better resuscitation solution...
  21. pmc Delaying blood transfusion in experimental acute anemia with a perfluorocarbon emulsion
    Pedro Cabrales
    Department of Bioengineering, University of California, San Diego, La Jolla, California 92093 0412, USA
    Anesthesiology 114:901-11. 2011
    ..The objective of this study was to determine systemic and microvascular effects of using a perfluorocarbon-based oxygen carrier (PFCOC) to maintain perfusion and oxygenation during extreme anemia...
  22. pmc Reversal of hemoglobin-induced vasoconstriction with sustained release of nitric oxide
    Pedro Cabrales
    Department of Bioengineering, University of California San Diego, La Jolla, California, USA
    Am J Physiol Heart Circ Physiol 300:H49-56. 2011
    ..Based on the observed physiological properties, NO-np has clear potential as a therapeutic agent to replenish NO in situations where NO production is impaired, insufficient, or consumed, thereby preventing vascular complications...
  23. pmc Tissue oxidative metabolism after extreme hemodilution with PEG-conjugated hemoglobin
    Pedro Cabrales
    Department of Bioengineering, University of California, San Diego, 9500 Gilman Dr, La Jolla, CA 92093 0412, USA
    J Appl Physiol (1985) 109:1852-9. 2010
    ..7 g Hb/dl) produces tissue anoxia, and high-O(2)-affinity PEG-Hb (Po(2) at which blood is 50% saturated with O(2) = 4 Torr, 1.1 g Hb/dl) only partially decreases anaerobic metabolism without increasing tissue Po(2)...
  24. pmc Sustained release nitric oxide from long-lived circulating nanoparticles
    Pedro Cabrales
    Department of Bioengineering, University of California, San Diego, La Jolla, CA 92093, USA
    Free Radic Biol Med 49:530-8. 2010
    ..Based on the observed physiological properties, NO-np has clear potential as a therapeutic agent and as a research tool to increase our understanding of NO signaling mechanisms within the vasculature...
  25. pmc Low oxygen-affinity hemoglobin solution increases oxygenation of partially ischemic tissue during acute anemia
    Pedro Cabrales
    Department of Bioengineering, University of California, San Diego, La Jolla, CA 92093, USA
    J Am Coll Surg 210:271-9. 2010
    ..When native O(2)-carrying capacity is lacking, fluids to improve O(2)-carrying capacity based in hemoglobin (Hb) could prevent partially ischemic tissue hypoxia by increasing O(2) release from the remaining red blood cells...
  26. pmc Tissue oxygenation after exchange transfusion with ultrahigh-molecular-weight tense- and relaxed-state polymerized bovine hemoglobins
    Pedro Cabrales
    La Jolla Bioengineering Institute, CA, USA
    Am J Physiol Heart Circ Physiol 298:H1062-71. 2010
    ....
  27. pmc Effects of the molecular mass of tense-state polymerized bovine hemoglobin on blood pressure and vasoconstriction
    Pedro Cabrales
    La Jolla Bioengineering Institute, 505 Coast Boulevard South, Suite 405, La Jolla, CA 92037, USA
    J Appl Physiol (1985) 107:1548-58. 2009
    ..Although mechanistically attractive, neither of these hypotheses can be directly tested in vivo and will require further investigation...
  28. pmc Exogenous nitric oxide induces protection during hemorrhagic shock
    Pedro Cabrales
    La Jolla Bioengineering Institute, 505 Coast Boulevard South Suite 405, La Jolla, CA 92037, United States
    Resuscitation 80:707-12. 2009
    ..Hemodynamic responses to hemorrhagic shock were studied in the hamster window chamber...
  29. pmc Isovolemic exchange transfusion with increasing concentrations of low oxygen affinity hemoglobin solution limits oxygen delivery due to vasoconstriction
    Pedro Cabrales
    La Jolla Bioengineering Institute, University of California, San Diego, La Jolla, CA, USA
    Am J Physiol Heart Circ Physiol 295:H2212-8. 2008
    ..Further studies to establish PBH optimal dosage, efficacy, safety, and its effect on outcome are indicated before Hb-based O2-carrying blood substitutes are implemented in routine practice...
  30. doi request reprint Polymerized bovine hemoglobin can improve small-volume resuscitation from hemorrhagic shock in hamsters
    Pedro Cabrales
    La Jolla Bioengineering Institute, University of California, San Diego, La Jolla, California 92037, USA
    Shock 31:300-7. 2009
    ....
  31. ncbi request reprint Oxygen release from arterioles with normal flow and no-flow conditions
    Pedro Cabrales
    La Jolla Bioengineering Institute, University of California San Diego, La Jolla, CA 92037, USA
    J Appl Physiol (1985) 100:1569-76. 2006
    ..6 vs. 1.8 x 10(-5) ml O2.cm(-2).s(-1), P < 0.05). The oxygen cost induced by wall shear stress, suggested by our findings, may be >15% of the total oxygen delivery to tissues by arterioles during flow in this preparation...
  32. ncbi request reprint Early difference in tissue pH and microvascular hemodynamics in hemorrhagic shock resuscitation using polyethylene glycol-albumin- and hydroxyethyl starch-based plasma expanders
    Pedro Cabrales
    La Jolla Bioengineering Institute, La Jolla, California 92037, USA
    Shock 24:66-73. 2005
    ..Furthermore, PEG-Alb appears to provide early and long-term sustained systemic and microvascular recovery when used to restitute perfusion and metabolic conditions after resuscitation from hemorrhagic shock...
  33. ncbi request reprint Alginate plasma expander maintains perfusion and plasma viscosity during extreme hemodilution
    Pedro Cabrales
    Dept of Bioengineering, 0412, University of California San Diego, 9500 Gilman Dr, La Jolla, CA 92093 0412, USA
    Am J Physiol Heart Circ Physiol 288:H1708-16. 2005
    ....
  34. ncbi request reprint Increased tissue PO2 and decreased O2 delivery and consumption after 80% exchange transfusion with polymerized hemoglobin
    Pedro Cabrales
    Dept of Bioengineering, 0412, Univ of California, San Diego, 9500 Gilman Dr, La Jolla, CA 92093 0412, USA
    Am J Physiol Heart Circ Physiol 287:H2825-33. 2004
    ..These results suggest the impairment of tissue O2 metabolism after introduction of PBH into the circulation, which is mitigated as PBH concentration declines...
  35. ncbi request reprint Effects of extreme hemodilution with hemoglobin-based O2 carriers on microvascular pressure
    Pedro Cabrales
    Department of Bioengineering, University of California San Diego, La Jolla, CA 92093 0412, USA
    Am J Physiol Heart Circ Physiol 288:H2146-53. 2005
    ..Microvascular resistance in arterioles with a diameter range of 70-80 microm showed an increase relative to control with alpha alpha Hb, whereas MP4 caused a decrease...
  36. pmc Low dose nitrite enhances perfusion after fluid resuscitation from hemorrhagic shock
    Pedro Cabrales
    La Jolla Bioengineering Institute, 505 Coast Boulevard South Suite 405, La Jolla, CA 92037, United States
    Resuscitation 80:1431-6. 2009
    ..In conclusion, increasing nitrite plasma bioavailability after fluid resuscitation from hemorrhagic shock can be a potential therapy to enhance microvascular perfusion and to improve overall outcome...
  37. ncbi request reprint Increase plasma viscosity sustains microcirculation after resuscitation from hemorrhagic shock and continuous bleeding
    Pedro Cabrales
    La Jolla Bioengineering Institute, La Jolla, California 92093 0412, USA
    Shock 23:549-55. 2005
    ..These findings suggest the possibility of using hyperviscous plasma expanders to prolong the period for initial treatment of blood losses and definitive institution therapy...
  38. ncbi request reprint Oxygen delivery and consumption in the microcirculation after extreme hemodilution with perfluorocarbons
    Pedro Cabrales
    University of California San Diego, Department of Bioengineering, 0412, 9500 Gilman Dr, La Jolla, CA 92093, USA
    Am J Physiol Heart Circ Physiol 287:H320-30. 2004
    ..Oxygen ventilation (100%) led to a positive base excess for the PFC group (5.5 +/- 2.5 mmol/l) versus a negative balance (-0.8 +/- 1.4 mmol/l) for the HES 200 group, suggesting that microvascular findings corresponded to systemic events...
  39. ncbi request reprint Microvascular PO2 during extreme hemodilution with hemoglobin site specifically PEGylated at Cys-93(beta) in hamster window chamber
    Pedro Cabrales
    Dept of Bioengineering 0412, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0412, USA
    Am J Physiol Heart Circ Physiol 287:H1609-17. 2004
    ..42 ml O(2)/dl blood). The total hemoglobin in blood was similar in all cases; therefore, the improvement in tissue Po(2) and oxygen delivery appears to be due to the increased cooperativity of the new molecules...
  40. ncbi request reprint Extreme hemodilution with PEG-hemoglobin vs. PEG-albumin
    Pedro Cabrales
    La Jolla Bioengineering Institute, 505 Coast Blvd S, Suite 405, La Jolla, CA 92037, USA
    Am J Physiol Heart Circ Physiol 289:H2392-400. 2005
    ..MP4 was significantly higher than MPA (P < 0.05) and was not statistically different from baseline, an effect due to the additional oxygen release to the tissue by the Hb MP4...
  41. ncbi request reprint Hyperosmotic-hyperoncotic versus hyperosmotic-hyperviscous: small volume resuscitation in hemorrhagic shock
    Pedro Cabrales
    Department of Bioengineering, University of California, San Diego, La Jolla, CA 92093, USA
    Shock 22:431-7. 2004
    ....
  42. ncbi request reprint Microvascular pressure and functional capillary density in extreme hemodilution with low- and high-viscosity dextran and a low-viscosity Hb-based O2 carrier
    Pedro Cabrales
    University of California, Department of Bioengineering, 0412, 9500 Gilman Dr, La Jolla, CA 92093 0412, USA
    Am J Physiol Heart Circ Physiol 287:H363-73. 2004
    ..The use of PBH increased mean arterial pressure but reduced capillary pressure due to vasoconstriction and did not maintain FCD...
  43. ncbi request reprint Oxygen transport by low and normal oxygen affinity hemoglobin vesicles in extreme hemodilution
    Pedro Cabrales
    Dept of Bioengineering 0412, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0412, USA
    Am J Physiol Heart Circ Physiol 288:H1885-92. 2005
    ..the HbV(29) and rHSA groups (P < 0.05). Improved tissue Po(2) is obtained when red blood cells deliver oxygen in combination with a high- rather than low-affinity oxygen carrier...
  44. ncbi request reprint Nitric oxide regulation of microvascular oxygen exchange during hypoxia and hyperoxia
    Pedro Cabrales
    La Jolla Bioengineering Institute, 505 Coast Blvd South, Suite 405, CA 92037, USA
    J Appl Physiol (1985) 100:1181-7. 2006
    ..The vessel wall consumes oxygen in proportion to the local Po2, and an impairment of NO availability renders the circulation more sensitive to changes in the oxygen supply...
  45. ncbi request reprint Measurement of the cardiac output in small animals by thermodilution
    Pedro Cabrales
    Department of Bioengineering, University of California, San Diego, La Jolla, CA 92093, USA
    Microvasc Res 66:77-82. 2003
    ..0 +/- 18.8 (ml/min)/kg. Repeated measurements were made. This technique allows correlating systemic flow changes to be correlated to those measured in the microcirculation of window chamber preparations...
  46. pmc Microvascular experimental evidence on the relative significance of restoring oxygen carrying capacity vs. blood viscosity in shock resuscitation
    Beatriz Y Salazar Vázquez
    Faculty of Medicine, Universidad Juarez del Estado de Durango, 34000 Victoria de Durango, Durango, Mexico
    Biochim Biophys Acta 1784:1421-7. 2008
    ..Achievement of this goal, in combination with the increase of oxygen affinity, significantly postpones the need for a blood transfusion, and lowers the total requirement of restoration of intrinsic oxygen carrying capacity...
  47. ncbi request reprint Elevated plasma viscosity in extreme hemodilution increases perivascular nitric oxide concentration and microvascular perfusion
    Amy G Tsai
    Dept of Bioengineering, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0412, USA
    Am J Physiol Heart Circ Physiol 288:H1730-9. 2005
    ..Results support the concept that in extreme hemodilution HV plasma maintains functional capillary density through a NO-mediated vasodilatation...
  48. ncbi request reprint Microvascular perfusion upon exchange transfusion with stored red blood cells in normovolemic anemic conditions
    Amy G Tsai
    Department of Bioengineering, University of California at San Diego, La Jolla 92093 0412, USA
    Transfusion 44:1626-34. 2004
    ..Transfusions are intended to augment oxygen-carrying capacity. The ability of fresh and stored red blood cells (RBCs) to maintain microvascular perfusion and oxygen delivery to the tissue has not been directly measured...
  49. pmc PEG-albumin supraplasma expansion is due to increased vessel wall shear stress induced by blood viscosity shear thinning
    Krishna Sriram
    Department of Mechanical and Aerospace Engineering, University of California San Diego, La Jolla, California 92093 0412, USA
    Am J Physiol Heart Circ Physiol 302:H2489-97. 2012
    ..These changes act synergistically, significantly increasing cardiac output and perfusion due to lowered overall peripheral vascular resistance...
  50. ncbi request reprint Oxygen-carrying blood substitutes: a microvascular perspective
    Amy G Tsai
    Department of Bioengineering, University of California, San Diego, 9500 Gilman Dr, La Jolla, CA 92093, USA
    Expert Opin Biol Ther 4:1147-57. 2004
    ....
  51. pmc Hypervolemic infusion of Lumbricus terrestris erythrocruorin purified by tangential-flow filtration
    Jacob Elmer
    William G Lowrie Department of Chemical and Biomolecular Engineering, The Ohio State University, Columbus, Ohio 43210, USA
    Transfusion 52:1729-40. 2012
    ..However, a suitable purification process must be developed to produce highly pure LtEc on a large scale that can be evaluated in an animal model to determine the safety and efficacy of LtEc...
  52. ncbi request reprint Microvascular and systemic effects following top load administration of saturated carbon monoxide-saline solution
    Nanae Hangai-Hoger
    Department of Bioengineering, University of California, San Diego, La Jolla, CA, USA
    Crit Care Med 35:1123-32. 2007
    ..To determine how top loads with different doses of carbon monoxide (CO)-saturated saline solutions (CO-saline) affect microvascular and systemic hemodynamics and to delineate the corresponding biochemical mechanisms...
  53. doi request reprint Nonlinear cardiovascular regulation consequent to changes in blood viscosity
    Beatriz Y Salazar Vázquez
    Department of Bioengineering, University of California, San Diego, La Jolla, CA 92093 0412, USA
    Clin Hemorheol Microcirc 49:29-36. 2011
    ....
  54. pmc Survival time in severe hemorrhagic shock after perioperative hemodilution is longer with PEG-conjugated human serum albumin than with HES 130/0.4: a microvascular perspective
    Judith Martini
    Department of Bioengineering, University of California, San Diego, Gilman Dr, La Jolla, California 92093, USA
    Crit Care 12:R54. 2008
    ....
  55. ncbi request reprint Microvascular effects following treatment with polyethylene glycol-albumin in lipopolysaccharide-induced endotoxemia
    Nanae Hangai-Hoger
    Department of Bioengineering, University of California, San Diego, La Jolla, CA 92093 0412, USA
    Crit Care Med 34:108-17. 2006
    ..5% weight/volume) infused at 16 mL/kg/hr (PEG-BSA-16) or at 24 mL/kg/hr (PEG-BSA-24) for 1 hr improves microcirculatory conditions in endotoxemia compared with dextran 70 (6% weight/volume) infused at 24 mL/kg/hr (Dex)...
  56. pmc Autoregulation and mechanotransduction control the arteriolar response to small changes in hematocrit
    Krishna Sriram
    Department of Mechanical and Aerospace Engineering, University of California San Diego, La Jolla, California 92093 0412, USA
    Am J Physiol Heart Circ Physiol 303:H1096-106. 2012
    ..They also suggest beneficial effects independent of changes in O(2) carrying capacity associated with the postsurgical transfusion of one or two units of blood...
  57. pmc Increased hemoglobin O2 affinity protects during acute hypoxia
    Ozlem Yalcin
    Department of Bioengineering, University of California, San Diego, La Jolla, USA
    Am J Physiol Heart Circ Physiol 303:H271-81. 2012
    ..This acute acclimatization process may have implications in survival during severe environmental hypoxia when logistic constraints prevent chronic acclimatization...
  58. ncbi request reprint Microvascular oxygen distribution in awake hamster window chamber model during hyperoxia
    Amy G Tsai
    Department of Bioengineering, University of California, San Diego, 9500 Gilman Dr, La Jolla, CA 92093 0412, USA
    Am J Physiol Heart Circ Physiol 285:H1537-45. 2003
    ....
  59. pmc The variability of blood pressure due to small changes of hematocrit
    Beatriz Y Salazar Vázquez
    Faculty of Medicine, Universidad Juarez del Estado de Durango, Victoria de Durango, Durango, Mexico
    Am J Physiol Heart Circ Physiol 299:H863-7. 2010
    ..In conclusion, limited acute anemic conditions increase mean arterial blood pressure during the initial period of 2 h, an effect that is quantitatively similar but opposite to the acute increase of Hct during the same period...
  60. pmc Improving cardiac function with new-generation plasma volume expanders
    Surapong Chatpun
    Department of Bioengineering, University of California San Diego, La Jolla, CA 92093, USA
    Am J Emerg Med 31:54-63. 2013
    ..Polyethylene glycol conjugation to human serum albumin (HSA), PEG-HSA, increases size, weight, and colloidal osmotic pressure, with minor effects on solution viscosity...
  61. ncbi request reprint Resuscitation from hemorrhagic shock with MalPEG-albumin: comparison with MalPEG-hemoglobin
    Reto Wettstein
    Department of Bioengineering, University of California, San Diego, La Jolla, CA 92093 0412 USA
    Shock 22:351-7. 2004
    ..7 cP (vs. 2.5 cP for MalPEG-Hb). The present results show that both solutions are efficacious plasma expanders and that the hemoglobin-based solution provides improved oxygen distribution and tissue Po2 in the hamster chamber model...
  62. ncbi request reprint Role of endothelial nitric oxide in microvascular oxygen delivery and consumption
    Pedro Cabrales
    La Jolla Bioengineering Institute, La Jolla, CA 92037, USA
    Free Radic Biol Med 39:1229-37. 2005
    ..Finally, the findings of the study support the argument that NO availability limits oxygen consumption by the tissue...
  63. ncbi request reprint Plasma expander viscosity effects on red cell-free layer thickness after moderate hemodilution
    Ozlem Yalcin
    Department of Bioengineering, University of California, San Diego, La Jolla, CA 92093 0412, USA
    Biorheology 48:277-91. 2011
    ..This study relates the perfusion caused by PolyHSA60:1 to hemodynamic changes induced by the rheological properties of blood diluted with PolyHSA60:1...
  64. ncbi request reprint Increased cardiac output and microvascular blood flow during mild hemoconcentration in hamster window model
    Judith Martini
    Department of Bioengineering, University of California, San Diego, La Jolla, CA 92093 0412, USA
    Am J Physiol Heart Circ Physiol 291:H310-7. 2006
    ..We conclude that a minimum viscosity level is necessary for generating the shear stress required for maintaining normal cardiovascular function...
  65. pmc Exogenous nitric oxide decreases brain vascular inflammation, leakage and venular resistance during Plasmodium berghei ANKA infection in mice
    Graziela M Zanini
    La Jolla Bioengineering Institute, San Diego, CA, USA
    J Neuroinflammation 8:66. 2011
    ..Here we evaluated whether the mechanism of action of NO in preventing murine CM is related to its anti-inflammatory properties and to protection of the endothelium...
  66. ncbi request reprint The vascular wall as a regulator of tissue oxygenation
    Amy G Tsai
    Department of Bioengineering 0412, University of California San Diego, La Jolla, CA 92093, USA
    Curr Opin Nephrol Hypertens 15:67-71. 2006
    ..This review presents the current status of in-vivo studies on the partitioning of oxygen between blood, the vascular wall and the surrounding tissue, thereby positioning an oxygen sink between blood and tissue regulating oxygen release...
  67. ncbi request reprint Radial displacement of red blood cells during hemodilution and the effect on arteriolar oxygen profile
    Juan Carlos Briceno
    Dept of Bioengineering, 0412, Univ of California San Diego, 9500 Gilman Dr, La Jolla, CA 92093 0412, USA
    Am J Physiol Heart Circ Physiol 286:H1223-8. 2004
    ..Po(2) profiles in the arterioles assumed an increasingly parabolic configuration with increasing levels of hemodilution...
  68. pmc Murine cerebral malaria is associated with a vasospasm-like microcirculatory dysfunction, and survival upon rescue treatment is markedly increased by nimodipine
    Pedro Cabrales
    La Jolla Bioengineering Institute, 505 Coast Boulevard South Suite 406, La Jolla, CA 92037, USA
    Am J Pathol 176:1306-15. 2010
    ..Administration of nimodipine induced vasodilation and increased pial blood flow. We conclude that vasoconstriction and vascular collapse play a role in murine CM pathogenesis and nimodipine holds potential as adjunctive therapy for CM...
  69. ncbi request reprint Microcirculatory changes during chronic adaptation to hypoxia
    ENRIQUE SALDIVAR
    Department of Bioengineering, University of California San Diego, La Jolla, CA 92093, USA
    Am J Physiol Heart Circ Physiol 285:H2064-71. 2003
    ..5 +/- 0.07 g/dl at control to 21.04 +/- 1.24 g/dl in the adapted animals (P < 0.05)...
  70. doi request reprint Microcirculatory effects of changing blood hemoglobin oxygen affinity during hemorrhagic shock resuscitation in an experimental model
    Nivaldo R Villela
    Department of Bioengineering, University of California San Diego, La Jolla, California 92093 0412, USA
    Shock 31:645-52. 2009
    ..These results suggest that lowering blood P50 in resuscitation provides improved microvascular function in comparison with higher P50...
  71. ncbi request reprint Time-dependant oxygen partial pressure in capillaries and tissue in the hamster window chamber model
    Pedro Cabrales
    La Jolla Bioengineering Institute, La Jolla, CA, USA
    Antioxid Redox Signal 9:845-53. 2007
    ..These findings suggest that resistance to oxygen diffusion in plasma is a minor factor in tissue oxygenation by capillaries in the hamster model...
  72. pmc Lowering of blood pressure by increasing hematocrit with non nitric oxide scavenging red blood cells
    Beatriz Y Salazar Vázquez
    Department of Bioengineering, University of California, San Diego, 9500 Gilman Dr, La Jolla, CA 92037 0412, USA
    Am J Respir Cell Mol Biol 38:135-42. 2008
    ..Consequently, MetRBCs increased the viscosity related hypotension range compared with functional RBCs as NO shear stress vasodilation mediated responses are greater...
  73. ncbi request reprint Microvascular perspective of oxygen-carrying and -noncarrying blood substitutes
    Marcos Intaglietta
    Department of Bioengineering, University of California, San Diego, La Jolla, California 92093 0412, USA
    Annu Rev Biomed Eng 8:289-321. 2006
    ..A feature of this material is that it is effective in small quantities, and therefore amplifies the equivalent supply of blood derived from blood donations...
  74. ncbi request reprint Microvascular oxygen delivery and consumption following treatment with verapamil
    Nanae Hangai-Hoger
    Dept of Bioengineering, 0412, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0412, USA
    Am J Physiol Heart Circ Physiol 288:H1515-20. 2005
    ..These findings show that treatment with verapamil, which increases oxygen supply through vasodilatation, may further improve tissue oxygenation by lowering oxygen consumption of the microcirculation...
  75. pmc Nitric oxide protection against murine cerebral malaria is associated with improved cerebral microcirculatory physiology
    Pedro Cabrales
    La Jolla Bioengineering Institute, La Jolla, CA 92037, USA
    J Infect Dis 203:1454-63. 2011
    ..5 vs 10.9 adherent leukocytes per 100 μm vessel length) compared with saline treatment. In conclusion, NO protection against CM is associated with improved brain microcirculatory hemodynamics and decreased vascular pathology...
  76. ncbi request reprint Terminal lymphatics: the potential "lethal corner" in the distribution of tissue pO2
    Nanae Hangai-Hoger
    Department of Bioengineering, University of California, San Diego, La Jolla, California 92093 0412, USA
    Lymphat Res Biol 5:159-68. 2007
    ..Terminal lymphatic fluid is the compartment furthest removed from the oxygen supply, and therefore should present the lowest pO(2) in the tissue due to oxygen consumption by the tissue and the lymphatic vessel wall...
  77. ncbi request reprint Oxygen distribution and respiration by the microcirculation
    Amy G Tsai
    Department of Bioengineering, University of California, San Diego, La Jolla, CA 92093 0412, USA
    Antioxid Redox Signal 6:1011-8. 2004
    ..Oxygen consumption by the endothelium and/or smooth muscle is also a factor in causing terminal lymphatic pO(2) to have the lowest oxygen level in the tissue, rendering this compartment most vulnerable in hypoxic conditions...
  78. pmc Perfusion vs. oxygen delivery in transfusion with "fresh" and "old" red blood cells: the experimental evidence
    Amy G Tsai
    Department of Bioengineering, University of California, San Diego, CA 92093 0412, USA
    Transfus Apher Sci 43:69-78. 2010
    ..Although experimental studies seldom reproduce emergency and clinical conditions, nonetheless they serve to explore fundamental physiological mechanisms in the microcirculation that cannot be directly studied in humans...
  79. ncbi request reprint Microlymphatic and tissue oxygen tension in the rat mesentery
    Nanae Hangai-Hoger
    Dept of Bioengineering, 0412, Univ of California San Diego, 9500 Gilman Dr, La Jolla, CA 92093 0412, USA
    Am J Physiol Heart Circ Physiol 286:H878-83. 2004
    ..The disparity between lymph and tissue Po(2) is attributed to the microlymphatic vessel wall and lymphocyte oxygen consumption...
  80. pmc Hematocrit and mean arterial blood pressure in pre- and postmenopause women
    Beatriz Y Salazar Vázquez
    Department of Bioengineering, University of California, San Diego, 9500 Gilman Dr, La Jolla, CA 92037 0412, USA
    Vasc Health Risk Manag 5:483-8. 2009
    ..Comparison with a large group of postmenopause women in the city of Stockholm showed identical trends...
  81. ncbi request reprint Excessive erythrocytosis does not elevate capillary oxygen delivery in subcutaneous mouse tissue
    Thomas Frietsch
    Department of Anesthesiology and Critical Care Medicine, Medical Faculty Mannheim of the University of Heidelberg, Germany
    Microcirculation 14:111-23. 2007
    ..These animals have been previously reported to elevate their blood viscosity 4-fold...
  82. ncbi request reprint New phosphorescence quenching oxygen measurements technique yields unusual tissue and plasma PO2 distributions
    Amy G Tsai
    J Appl Physiol 102:2081-2; author reply 2083. 2007
  83. ncbi request reprint Oxygen release from low and normal P50 Hb vesicles in transiently occluded arterioles of the hamster window model
    Hiromi Sakai
    Advanced Research Institute for Science and Engineering, Waseda Univ, Tokyo 169 8555, Japan
    Am J Physiol Heart Circ Physiol 288:H2897-903. 2005
    ..55) overwhelming red blood cells when the Po(2) was reduced (e.g., <10 mmHg) despite a small dosage of HbV. This result supports the possible utilization of Hb-based O(2) carriers with lower P(50) for oxygenation of ischemic tissues...
  84. ncbi request reprint Can the effects of vasoactivity of molecular hemoglobin-based plasma expanders be ignored?
    Amy G Tsai
    Crit Care Med 34:1566-7. 2006
  85. doi request reprint Oxygen transport during hemodilution with a perfluorocarbon-based oxygen carrier: effect of altitude and hyperoxia
    Tatiana Gardeazábal
    Blood Substitutes Laboratory, Fundación Cardio Infantil, Carrera 1 Este No 19 40, Office ML817, University of Los Andes, PO Box 4976, Bogota, Colombia
    J Appl Physiol (1985) 105:588-94. 2008
    ..Therefore, the efficacy of PFCOCs at 2,600 m above sea level is reduced, and altitude must be taken into account when PFCOCs are used...
  86. ncbi request reprint Effect of oxygen consumption by measuring method on PO2 transients associated with the passage of erythrocytes in capillaries of rat mesentery
    Amy G Tsai
    Am J Physiol Heart Circ Physiol 289:H1777; author reply H1778-9. 2005
    ..72) was higher than that for the other half (mean Po(2) = 39 mmHg; R = -0.38). These results support the theoretical predictions of EATs and plasma Po(2) gradients in capillaries...
  87. ncbi request reprint Blood viscosity: a factor in tissue survival?
    Amy G Tsai
    Crit Care Med 33:1662-3. 2005
  88. ncbi request reprint Increased hematocrit and reduced blood pressure following control of glycemia in diabetes
    Beatriz Y Salazar Vázquez
    Faculty of Medicine, Universidad Juarez del Estado de Durango, Durango, Mexico
    Clin Hemorheol Microcirc 38:57-64. 2008
    ..It is proposed that these effects are in part related to improved kidney function resulting in increased Hct and blood viscosity which increases vascular wall shear stress and NO bioavailability leading to a vasodilator effect...