Daniel Buysse

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. pmc Which symptoms predict recurrence of depression in women treated with maintenance interpersonal psychotherapy?
    Alexandre Y Dombrovski
    Western Psychiatric Institute and Clinic, Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Depress Anxiety 25:1060-6. 2008
  2. pmc Insomnia
    Daniel J Buysse
    Neuroscience Clinical and Translational Research Center, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    JAMA 309:706-16. 2013
  3. ncbi request reprint Regional brain glucose metabolism during morning and evening wakefulness in humans: preliminary findings
    Daniel J Buysse
    Department of Psychiatry, University of Pittsburgh School of Medicine, University of Pittsburgh Medical Center, Pennsylvania, USA
    Sleep 27:1245-54. 2004
  4. pmc Development and validation of patient-reported outcome measures for sleep disturbance and sleep-related impairments
    Daniel J Buysse
    Department of Psychiatry, University of Pittsburgh School of Medicine, PA, USA
    Sleep 33:781-92. 2010
  5. ncbi request reprint Recommendations for a standard research assessment of insomnia
    Daniel J Buysse
    Department of Psychiatry, University of Pittsburgh School of Medicine, PA, USA
    Sleep 29:1155-73. 2006
  6. pmc Chronic insomnia
    Daniel J Buysse
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Am J Psychiatry 165:678-86. 2008
  7. pmc Night-to-night sleep variability in older adults with and without chronic insomnia
    Daniel J Buysse
    Sleep Medicine Institute and Neuroscience Clinical and Translational Research Center, Department of Psychiatry, School of Medicine, University of Pittsburgh, PA 15213, USA
    Sleep Med 11:56-64. 2010
  8. pmc EEG spectral analysis in primary insomnia: NREM period effects and sex differences
    Daniel J Buysse
    Neuroscience Clinical and Translational Research Center and Sleep Medicine Institute, University ofPittsburgh School ofMedicine, Pittsburgh, PA, USA
    Sleep 31:1673-82. 2008
  9. pmc Daytime symptoms in primary insomnia: a prospective analysis using ecological momentary assessment
    Daniel J Buysse
    Neuroscience Clinical and Translational Research Center, Department of Psychiatry, University of Pittsburgh, School of Medicine, USA
    Sleep Med 8:198-208. 2007
  10. pmc Relationships between the Pittsburgh Sleep Quality Index (PSQI), Epworth Sleepiness Scale (ESS), and clinical/polysomnographic measures in a community sample
    Daniel J Buysse
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA
    J Clin Sleep Med 4:563-71. 2008

Collaborators

Detail Information

Publications91

  1. pmc Which symptoms predict recurrence of depression in women treated with maintenance interpersonal psychotherapy?
    Alexandre Y Dombrovski
    Western Psychiatric Institute and Clinic, Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Depress Anxiety 25:1060-6. 2008
    ..We therefore examined the impact of persistent symptoms, including mood, insomnia, and anxiety symptoms, on time to recurrence in women receiving maintenance interpersonal psychotherapy (IPT-M) for recurrent depression...
  2. pmc Insomnia
    Daniel J Buysse
    Neuroscience Clinical and Translational Research Center, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    JAMA 309:706-16. 2013
    ..Clinicians may be reluctant to address insomnia because of its many potential causes, unfamiliarity with behavioral treatments, and concerns about pharmacologic treatments...
  3. ncbi request reprint Regional brain glucose metabolism during morning and evening wakefulness in humans: preliminary findings
    Daniel J Buysse
    Department of Psychiatry, University of Pittsburgh School of Medicine, University of Pittsburgh Medical Center, Pennsylvania, USA
    Sleep 27:1245-54. 2004
    ..The goal of this pilot study was to examine regional relative brain glucose metabolism during morning and evening wakefulness in healthy humans...
  4. pmc Development and validation of patient-reported outcome measures for sleep disturbance and sleep-related impairments
    Daniel J Buysse
    Department of Psychiatry, University of Pittsburgh School of Medicine, PA, USA
    Sleep 33:781-92. 2010
    ....
  5. ncbi request reprint Recommendations for a standard research assessment of insomnia
    Daniel J Buysse
    Department of Psychiatry, University of Pittsburgh School of Medicine, PA, USA
    Sleep 29:1155-73. 2006
    ..To present expert consensus recommendations for a standard set of research assessments in insomnia, reporting standards for these assessments, and recommendations for future research...
  6. pmc Chronic insomnia
    Daniel J Buysse
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Am J Psychiatry 165:678-86. 2008
  7. pmc Night-to-night sleep variability in older adults with and without chronic insomnia
    Daniel J Buysse
    Sleep Medicine Institute and Neuroscience Clinical and Translational Research Center, Department of Psychiatry, School of Medicine, University of Pittsburgh, PA 15213, USA
    Sleep Med 11:56-64. 2010
    ....
  8. pmc EEG spectral analysis in primary insomnia: NREM period effects and sex differences
    Daniel J Buysse
    Neuroscience Clinical and Translational Research Center and Sleep Medicine Institute, University ofPittsburgh School ofMedicine, Pittsburgh, PA, USA
    Sleep 31:1673-82. 2008
    ..To compare NREM EEG power in primary insomnia (PI) and good sleeper controls (GSC), examining both sex and NREM period effects; to examine relationships between EEG power, clinical characteristics, and self-reports of sleep...
  9. pmc Daytime symptoms in primary insomnia: a prospective analysis using ecological momentary assessment
    Daniel J Buysse
    Neuroscience Clinical and Translational Research Center, Department of Psychiatry, University of Pittsburgh, School of Medicine, USA
    Sleep Med 8:198-208. 2007
    ....
  10. pmc Relationships between the Pittsburgh Sleep Quality Index (PSQI), Epworth Sleepiness Scale (ESS), and clinical/polysomnographic measures in a community sample
    Daniel J Buysse
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA
    J Clin Sleep Med 4:563-71. 2008
    ....
  11. ncbi request reprint Fresh from the pipeline: Ramelteon
    Daniel Buysse
    University of Pittsburgh School of Medicine, Pennsylvania 15213, USA
    Nat Rev Drug Discov 4:881-2. 2005
  12. doi request reprint Can an improvement in sleep positively impact on health?
    Daniel J Buysse
    University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Sleep Med Rev 14:405-10. 2010
    ..article documents the debate session from the 6th International Sleep Disorders Forum -The Art of Good Sleep, held in Toronto, Canada in September 2008; the topic of which was "Does an improvement in sleep positively impact on health?"..
  13. pmc Prevalence, course, and comorbidity of insomnia and depression in young adults
    Daniel J Buysse
    Department ofPsychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Sleep 31:473-80. 2008
    ..1) To describe the prevalence and prospective course of insomnia in a representative young-adult sample and (2) to describe the cross-sectional and longitudinal associations between insomnia and depression...
  14. ncbi request reprint Circadian patterns of sleep, sleepiness, and performance in older and younger adults
    Daniel J Buysse
    Sleep and Chronobiology Program, University of Pittsburgh, PA, USA
    Sleep 28:1365-76. 2005
    ..To compare circadian patterns of sleep, subjective sleepiness, and psychomotor performance in older and younger adults...
  15. pmc Efficacy of brief behavioral treatment for chronic insomnia in older adults
    Daniel J Buysse
    Sleep Medicine Institute, Department of Psychiatry, University of Pittsburgh School of Medicine, USA
    Arch Intern Med 171:887-95. 2011
    ..Cognitive behavioral treatments are efficacious but not widely available. The aim of this study was to test the efficacy of brief behavioral treatment for insomnia (BBTI) vs an information control (IC) condition...
  16. ncbi request reprint Focusing on the experience of insomnia
    Thomas J Carey
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Behav Sleep Med 3:73-86. 2005
    ..Daytime problems are salient descriptors of the insomnia experience. Assessing the patient's daytime experiences is valued by patients with insomnia and may be used as a benchmark for treatment response...
  17. pmc Low life purpose and high hostility are related to an attenuated decline in nocturnal blood pressure
    Elizabeth J Mezick
    Department of Psychology, University of Pittsburgh, PA 15213, USA
    Health Psychol 29:196-204. 2010
    ..We investigated whether positive and negative psychological attributes were associated with sleep-wake BP ratios and examined sleep parameters as potential mediators of these relationships...
  18. pmc Influence of race and socioeconomic status on sleep: Pittsburgh SleepSCORE project
    Elizabeth J Mezick
    Department of Psychology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Psychosom Med 70:410-6. 2008
    ..To examine the independent and interactive effects of race and socioeconomic status (SES) on objective indices and self-reports of sleep...
  19. ncbi request reprint Circadian and homeostatic modulation of sleep in older adults during a 90-minute day study
    Keith A Niggemyer
    Division of Pulmonary, Allergy, and Critical Care Medicine, University of Pittsburgh, Pennsylvania, USA
    Sleep 27:1535-41. 2004
    ..To identify age-associated changes in circadian and homeostatic characteristics of sleep in healthy elderly and young adults using electroencephalogram (EEG) power spectral analysis during a 90-minute sleep-wake schedule...
  20. doi request reprint Comparison of sleep/wake behavior in CKD stages 4 to 5 and hemodialysis populations using wrist actigraphy
    Babak Barmar
    Renal Electrolyte Division, University of Pittsburgh Medical Center, Pittsburgh, PA 15261, USA
    Am J Kidney Dis 53:665-72. 2009
    ..We assessed the influence of hemodialysis on sleep/wake behavior by using wrist actigraphy and self-reported sleep quality compared with patients with chronic kidney disease (CKD) stages 4 to 5...
  21. pmc Subjective and objective sleep quality in patients on conventional thrice-weekly hemodialysis: comparison with matched controls from the sleep heart health study
    Mark L Unruh
    Renal Electrolyte Division, University of Pittsburgh Medical Center, Pittsburgh, PA 15261, USA
    Am J Kidney Dis 52:305-13. 2008
    ..It therefore is uncertain whether poor sleep quality in the HD population reflects age, chronic health conditions, or effects of conventional HD therapy...
  22. doi request reprint Subjective and objective sleep quality and aging in the sleep heart health study
    Mark L Unruh
    Renal Electrolyte Division, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15261, USA
    J Am Geriatr Soc 56:1218-27. 2008
    ..To examine the extent to which subjective and objective sleep quality are related to age independent of chronic health conditions...
  23. ncbi request reprint Psychophysiological reactivity and coping styles influence the effects of acute stress exposure on rapid eye movement sleep
    Anne Germain
    Department of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Psychosom Med 65:857-64. 2003
    ....
  24. ncbi request reprint Prevalence of obesity and weight change during treatment in patients with bipolar I disorder
    Andrea Fagiolini
    Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, PA 15213, USA
    J Clin Psychiatry 63:528-33. 2002
    ..Individuals with bipolar disorder tend to be overweight, and their treatment may exacerbate obesity and increase the risk of concurrent medical disease in this population...
  25. ncbi request reprint Electroencephalographic sleep profiles in single-episode and recurrent unipolar forms of major depression: II. Comparison during remission
    Ripu D Jindal
    Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, Pittsburgh, Pennsylvania 15213, USA
    Biol Psychiatry 51:230-6. 2002
    ..This study examines whether the observed differences in the sleep patterns during recurrent and single-episode depression persist into remission following nonpharmacologic treatment...
  26. ncbi request reprint A pilot study of subjective daytime alertness and mood in primary insomnia participants using ecological momentary assessment
    Helena Levitt
    Department of Psychiatry, University of Pittsburgh School of Medicine, PA, USA
    Behav Sleep Med 2:113-31. 2004
    ..Coefficients of variation for DSD domains were greater in the insomnia group. Frequent measures of daytime symptoms may be useful outcomes in insomnia studies...
  27. ncbi request reprint Effects of a brief behavioral treatment for late-life insomnia: preliminary findings
    Anne Germain
    Department Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    J Clin Sleep Med 2:403-6. 2006
    ..This preliminary report addresses the effects of a brief behavioral treatment for insomnia in older adults who present with the typical psychiatric and medical comorbidities of aging...
  28. ncbi request reprint Insomnia and hypersomnia associated with depressive phenomenology and comorbidity in childhood depression
    Xianchen Liu
    Department of Psychiatry, University of Pittsburgh School of Medicine and WPIC, PA 15213, USA
    Sleep 30:83-90. 2007
    ....
  29. ncbi request reprint Diagnosis and assessment of sleep and circadian rhythm disorders
    Daniel J Buysse
    University of Pittsburgh School of Medicine, PA 15213, USA
    J Psychiatr Pract 11:102-15. 2005
    ..Methods of assessing sleep complaints are then described, including taking an accurate history from the patient and bed partner, use of sleep history questionnaires and sleep-wake diaries, use of actigraphy, and use of PSG...
  30. pmc Resistant hypertension and obstructive sleep apnea in the setting of kidney disease
    Khaled Abdel-Kader
    Renal Electrolyte Division, University of Pittsburgh, Pittsburgh, PA 15261, USA
    J Hypertens 30:960-6. 2012
    ..To explore the relationship between obstructive sleep apnea (OSA) and resistant hypertension in chronic kidney disease (CKD) and end-stage renal disease (ESRD)...
  31. ncbi request reprint Psychological stress is associated with heightened physiological arousal during NREM sleep in primary insomnia
    Martica Hall
    Department of Psychiatry, University of Pittsburgh School of Medicine, 3811 O Hara Street, Pittsburgh, PA 15213, USA
    Behav Sleep Med 5:178-93. 2007
    ..Perceived stress and stress-related avoidance behaviors were associated with multiple indexes of physiological arousal during NREM sleep in patients with chronic, primary insomnia...
  32. pmc Blood pressure dipping and sleep disturbance in African-American and Caucasian men and women
    Karen A Matthews
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Am J Hypertens 21:826-31. 2008
    ..Elevated night time/daytime blood pressure (BP) ratios are associated with cardiovascular morbidity and mortality. We evaluated the associations between sleep/awake BP ratios and sleep disturbances...
  33. pmc Marital quality and the marital bed: examining the covariation between relationship quality and sleep
    Wendy M Troxel
    Department of Psychiatry, University of Pittsburgh, 3811 O Hara Street, Pittsburgh, PA 15213, USA
    Sleep Med Rev 11:389-404. 2007
    ....
  34. pmc Sleep deprivation alters pupillary reactivity to emotional stimuli in healthy young adults
    Peter L Franzen
    Department of Psychiatry, University of Pittsburgh School of Medicine, 3811 O Hara St, Pittsburgh, PA 15213, USA
    Biol Psychol 80:300-5. 2009
    ..Such responses may have important implications for psychiatric disorders, which may be triggered or characterized by sleep disturbances...
  35. pmc Poor sleep quality predicts onset of either major depression or subsyndromal depression with irritability during interferon-alpha treatment
    Peter L Franzen
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Psychiatry Res 177:240-5. 2010
    ..These findings may have important implications for understanding, predicting, and possibly preventing depression, particularly in individuals treated with IFN-alpha...
  36. pmc Are inflammatory and coagulation biomarkers related to sleep characteristics in mid-life women?: Study of Women's Health across the Nation sleep study
    Karen A Matthews
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Sleep 33:1649-55. 2010
    ....
  37. pmc Sleep symptoms predict the development of the metabolic syndrome
    Wendy M Troxel
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Sleep 33:1633-40. 2010
    ..This is the first prospective study to report the association between commonly reported sleep symptoms and the development of the metabolic syndrome, a key CVD risk factor...
  38. pmc Sleep variability, health-related practices, and inflammatory markers in a community dwelling sample of older adults
    Michele L Okun
    Sleep Medicine Institute and Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, Pittsburgh, PA 15213, USA
    Psychosom Med 73:142-50. 2011
    ..Health behaviors, including average aggregate measures of sleep, have been linked to increased inflammation in older adults. Variability in sleep timing may also be associated with increased inflammation...
  39. pmc Does social support differentially affect sleep in older adults with versus without insomnia?
    Wendy M Troxel
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213, USA
    J Psychosom Res 69:459-66. 2010
    ..We examined social support as a potential protective factor for sleep among older adults (60 years and older) with insomnia (n=79) and age- and sex-matched controls without insomnia (n=40)...
  40. pmc Napping, nighttime sleep, and cardiovascular risk factors in mid-life adults
    Jane F Owens
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213, USA
    J Clin Sleep Med 6:330-5. 2010
    ..To evaluate the relations between sleep characteristics and cardiovascular risk factors and napping behavior, and to assess whether daytime napping leads to subsequent better or worse sleep...
  41. pmc Marital/cohabitation status and history in relation to sleep in midlife women
    Wendy M Troxel
    Department of Psychiatry, University of Pittsburgh, 3811 O Hara Street, Pittsburgh, PA 15213, USA
    Sleep 33:973-81. 2010
    ..To examine whether current and/or history of marital/cohabitation status are associated with sleep, independent of demographic and general health risk factors...
  42. ncbi request reprint Maintenance treatment of insomnia: what can we learn from the depression literature?
    Ripu D Jindal
    Mental Health Intervention Research Center, University of Pittsburgh School of Medicine, PA 15213, USA
    Am J Psychiatry 161:19-24. 2004
    ..This article compares and contrasts the current state of research in the maintenance therapy of depression and insomnia and highlights gaps in the insomnia literature...
  43. pmc Comorbid insomnia and obstructive sleep apnea: challenges for clinical practice and research
    Faith S Luyster
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15261, USA
    J Clin Sleep Med 6:196-204. 2010
    ....
  44. pmc Sleep quality, mood, alertness and their variability in CKD and ESRD
    Maria Eleni Roumelioti
    Renal Electrolyte Division, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    Nephron Clin Pract 114:c277-87. 2010
    ..In this report, we assessed these symptoms among patients with advanced CKD (stages 4-5) and those with end-stage renal disease (ESRD) and compared them to healthy controls without known kidney disease...
  45. pmc What constitutes too long of a delay? Determining the cortisol awakening response (CAR) using self-report and PSG-assessed wake time
    Michele L Okun
    University of Pittsburgh School of Medicine, Department of Psychiatry, United States
    Psychoneuroendocrinology 35:460-8. 2010
    ..Later collection times and reduced CAR values may affect the interpretation of clinical associations. Our data also show that S-R assessments of wake time perform equally well to PSG for evaluating adherence with CAR sampling procedures...
  46. pmc Effects of a two-hour change in bedtime on the sleep of healthy seniors
    Timothy H Monk
    Neuroscience Clinical and Translational Research Center, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    Chronobiol Int 26:526-43. 2009
    ..There were no effects related to the phase angle between Tmin and rise-time. The relative benefits of longer vs. more efficient sleep in the elderly require further investigation...
  47. pmc Psychometric evaluation of the Insomnia Symptom Questionnaire: a self-report measure to identify chronic insomnia
    Michele L Okun
    University of Pittsburgh, Department of Psychiatry, Pittsburgh, PA 15213, USA
    J Clin Sleep Med 5:41-51. 2009
    ....
  48. pmc Race and financial strain are independent correlates of sleep in midlife women: the SWAN sleep study
    Martica H Hall
    Department of Psychiatry University of Pittsburgh, Pittsburgh, PA 15213, USA
    Sleep 32:73-82. 2009
    ..To examine racial differences in sleep in a large cohort of midlife women and to evaluate whether indices of socioeconomic status (SES) are associated with racial differences in sleep...
  49. pmc Circadian type and bed-timing regularity in 654 retired seniors: correlations with subjective sleep measures
    Timothy H Monk
    Neuroscience Clinical and Translational Research Center, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, 3811 O Hara Street, Pittsburgh, PA 15213, USA
    Sleep 34:235-9. 2011
    ..Using telephone interview data from retired seniors to explore how inter-individual differences in circadian type (morningness) and bed-timing regularity might be related to subjective sleep quality and quantity...
  50. ncbi request reprint Relationship of variability in residual symptoms with recurrence of major depressive disorder during maintenance treatment
    Jordan F Karp
    Western Psychiatric Institute and Clinic, 3811 O Hara St, Pittsburgh, PA 15213, USA
    Am J Psychiatry 161:1877-84. 2004
    ....
  51. ncbi request reprint Paroxetine treatment of primary insomnia in older adults
    Charles F Reynolds
    Advanced Center for Interventions and Services Research for Late Life Mood Disorders ACISR LLMD and the John A Hartford Center of Excellence in Geriatric Psychiatry, Western Psychiatric Institute and Clinic, Pittsburgh, PA, USA
    Am J Geriatr Psychiatry 14:803-7. 2006
    ..The goal of this study was to test the efficacy of paroxetine for primary insomnia in older adults...
  52. ncbi request reprint Sleep in healthy seniors: a diary study of the relation between bedtime and the amount of sleep obtained
    Timothy H Monk
    Clinical Neuroscience Research Center, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, PA 15213, USA
    J Sleep Res 15:256-60. 2006
    ..g. age-dependent alterations in phase angle and homeostatic sleep need)...
  53. ncbi request reprint Age-related differences in the lifestyle regularity of seniors experiencing bereavement, care-giving, insomnia, and advancement into old-old age
    Timothy H Monk
    Clinical Neuroscience Research Center, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA
    Chronobiol Int 23:831-41. 2006
    ..This may represent an adaptive behavioral response that might be used in future therapeutic approaches...
  54. ncbi request reprint Treating complicated grief: effects on sleep quality
    Anne Germain
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Behav Sleep Med 4:152-63. 2006
    ..Given that sleep disturbance is a risk factor for poor health outcomes, adjunctive sleep interventions may be necessary to enhance CGT outcomes...
  55. ncbi request reprint Human regional cerebral glucose metabolism during non-rapid eye movement sleep in relation to waking
    Eric A Nofzinger
    Department of Psychiatry, University of Pittsburgh School of Medicine, PA 15213 2593, USA
    Brain 125:1105-15. 2002
    ....
  56. ncbi request reprint Sleep quality in complicated grief
    Anne Germain
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pennsylvania 15213, USA
    J Trauma Stress 18:343-6. 2005
    ..Comorbid depression, but not PTSD, further worsened sleep quality. Further studies are required to investigate the potential role of poor sleep quality as a modifiable risk factor of complicated grief response...
  57. ncbi request reprint Alterations in regional cerebral glucose metabolism across waking and non-rapid eye movement sleep in depression
    Eric A Nofzinger
    Department of Psychiatry, Western Psychiatric Institute and Clinic, 3811 O Hara Street, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Arch Gen Psychiatry 62:387-96. 2005
    ..Non-rapid eye movement sleep is associated with decreases in frontal, parietal, and temporal cortex metabolic activity compared with wakefulness...
  58. ncbi request reprint Clinical correlates of poor sleep quality in posttraumatic stress disorder
    Anne Germain
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    J Trauma Stress 17:477-84. 2004
    ..Results suggest that age, gender, and psychiatric comorbidity have minimal impact on sleep quality in this PTSD sample. The inclusion of PTSD patients who were not specifically seeking treatment for SD reinforces the study findings...
  59. ncbi request reprint Using nine 2-h delays to achieve a 6-h advance disrupts sleep, alertness, and circadian rhythm
    Timothy H Monk
    Clinical Neuroscience Research Center, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
    Aviat Space Environ Med 75:1049-57. 2004
    ....
  60. ncbi request reprint Can sleep be bad for you? Can insomnia be good?
    Daniel J Buysse
    E 1127 TDH, Western Psychiatric Institute and Clinic, 3811 O Hara St, Pittsburgh, PA 15213, USA
    Arch Gen Psychiatry 59:137-8. 2002
  61. ncbi request reprint Self-report measures of insomnia in adults: rationales, choices, and needs
    Douglas E Moul
    Department of Psychiatry, Western Psychiatric Institute and Clinic, Sleep and Chronobiology Center, University of Pittsburgh, Room E 1119, 3811 O Hara Street, Pittsburgh, PA 15213, USA
    Sleep Med Rev 8:177-98. 2004
    ..An extensive table of currently available questionnaires is provided, and some needs for future questionnaire development are also identified...
  62. pmc Randomized trial of weekly, twice-monthly, and monthly interpersonal psychotherapy as maintenance treatment for women with recurrent depression
    Ellen Frank
    Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, 3811 O Hara St, Pittsburgh, PA 15213, USA
    Am J Psychiatry 164:761-7. 2007
    ..The authors sought to determine whether a greater frequency of interpersonal psychotherapy (IPT) sessions during maintenance treatment has a greater prophylactic effect than a previously validated once-a-month treatment...
  63. ncbi request reprint Masking effects of posture and sleep onset on core body temperature have distinct circadian rhythms: results from a 90-min/day protocol
    Douglas E Moul
    Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, PA 15213, USA
    J Biol Rhythms 17:447-62. 2002
    ..These findings confirm the need for nonlinear models of temperature responses to postural changes and sleep that incorporate circadian variability in these masking effects...
  64. ncbi request reprint Symptom reports in severe chronic insomnia
    Douglas E Moul
    Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, PA 15213, USA
    Sleep 25:553-63. 2002
    ..To describe patterns and severities of the daytime and nighttime symptoms of chronic insomnia patients...
  65. ncbi request reprint Functional neuroimaging evidence for hyperarousal in insomnia
    Eric A Nofzinger
    Western Psychiatric Institute and Clinic, Sleep Neuroimaging Research Program, Department of Psychiatry, University of Pittsburgh School of Medicine, 3811 O Hara St, Pittsburgh, PA 15213 2593, USA
    Am J Psychiatry 161:2126-8. 2004
    ..The authors investigated the neurobiological basis of poor sleep and daytime fatigue in insomnia...
  66. ncbi request reprint The relationship between lifestyle regularity and subjective sleep quality
    Timothy H Monk
    Clinical Neuroscience Research Center, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA
    Chronobiol Int 20:97-107. 2003
    ..Thus, there appears to be an association between lifestyle regularity and good sleep, though the direction of causality remains to be tested...
  67. ncbi request reprint Effects of a brief behavioral treatment for PTSD-related sleep disturbances: a pilot study
    Anne Germain
    Department of Psychiatry, University of Pittsburgh School of Medicine, PA, USA
    Behav Res Ther 45:627-32. 2007
    ..The goal of this pilot study was to explore the effects of a very brief intervention for PTSD-related nightmares and insomnia in victims of violent crimes with PTSD...
  68. ncbi request reprint Clinicians' use of the International Classification of Sleep Disorders: results of a national survey
    Daniel J Buysse
    University of Pittsburgh, Pittsburgh, PA, USA
    Sleep 26:48-51. 2003
    ..To determine clinicians' patterns of use of the International Classification of Sleep Disorders (ICSD) and their ratings of its utility and organization...
  69. pmc Self-reported sleep quality predicts poor cognitive performance in healthy older adults
    Robert D Nebes
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, PA 15213, USA
    J Gerontol B Psychol Sci Soc Sci 64:180-7. 2009
    ..Sleep problems may contribute to performance variability between elderly individuals but only in certain cognitive domains...
  70. ncbi request reprint Morningness-eveningness and lifestyle regularity
    Timothy H Monk
    Clinical Neuroscience Research Center, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA
    Chronobiol Int 21:435-43. 2004
    ..Thus it appears that morning types appear to be more regular in their daily lifestyle than are evening types, suggesting a relationship between these two aspects of human circadian behavior...
  71. ncbi request reprint Acute stress affects heart rate variability during sleep
    Martica Hall
    University of Pittsburgh Department of Psychiatry, Pittsburgh, PA, USA
    Psychosom Med 66:56-62. 2004
    ..In this study, we used autoregressive spectral analysis of the electrocardiogram (EKG) interbeat interval sequence to characterize stress-related changes in heart rate variability during sleep in 59 healthy men and women...
  72. ncbi request reprint Neurobiology of non-REM sleep in depression: further evidence for hypofrontality and thalamic dysregulation
    Anne Germain
    University of Pittsburgh School of Medicine, Department of Psychiatry, 3811 O Hara St, E 1116, Pittsburgh, PA 15213, USA
    Am J Psychiatry 161:1856-63. 2004
    ..The goal of this study was to investigate the functional neuroanatomical correlates of non-REM sleep relative to presleep wakefulness in depressed patients and healthy subjects...
  73. ncbi request reprint Functional neuroanatomical correlates of eye movements during rapid eye movement sleep in depressed patients
    Anne Germain
    Department of Psychiatry, University of Pittsburgh School of Medicine, 3811 O Hara Street, E 1116, Pittsburgh, PA 15213, USA
    Psychiatry Res 130:259-68. 2004
    ..The observed pattern of correlations suggests that average RC may be a marker of hypofrontality during REM sleep in depressed patients...
  74. ncbi request reprint The association between short sleep duration and obesity in young adults: a 13-year prospective study
    Gregor Hasler
    Mood and Anxiety Disorders Program, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA
    Sleep 27:661-6. 2004
    ..The objective of this study was to test the hypothesis that short sleep duration is associated with obesity and weight gain during young adulthood...
  75. ncbi request reprint Measuring sleep habits without using a diary: the sleep timing questionnaire
    Timothy H Monk
    Clinical Neuroscience Research Center, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, PA 15213, USA
    Sleep 26:208-12. 2003
    ..To develop a single-administration instrument yielding equivalent measures of sleep to those obtained from a formal (2-week) sleep diary...
  76. ncbi request reprint Microstructure of sleep in depressed patients according to the cyclic alternating pattern
    Benedetto Farina
    Institute of Psychiatry, Catholic University of Sacred Heart, via Alexander Fleming 110, 00191, Rome, Italy
    J Affect Disord 77:227-35. 2003
    ..The aim of this study was to evaluate the microstructure of the EEG sleep of depressed subjects by cyclic alternating pattern (CAP) analysis...
  77. ncbi request reprint Increased activation of anterior paralimbic and executive cortex from waking to rapid eye movement sleep in depression
    Eric A Nofzinger
    Department of Psychiatry, University of Pittsburgh School of Medicine, PA 15213 2593, USA
    Arch Gen Psychiatry 61:695-702. 2004
    ....
  78. ncbi request reprint A brief sleep scale for Posttraumatic Stress Disorder: Pittsburgh Sleep Quality Index Addendum for PTSD
    Anne Germain
    Department of Psychiatry, University of Pittsburgh School of Medicine, PA 15213, USA
    J Anxiety Disord 19:233-44. 2005
    ..The PSQI-A is a valid instrument for PTSD applicable to both clinical and research settings...
  79. pmc Chronic insomnia and MRI-measured hippocampal volumes: a pilot study
    Dieter Riemann
    Department of Psychiatry and Psychotherapy, Freiburg University Medical Center, Hauptstr 5, D 79104 Germany
    Sleep 30:955-8. 2007
    ..Morphometric analysis of magnetic resonance imaging brain scans was used to investigate possible neuroanatomic differences between patients with primary insomnia compared to good sleepers...
  80. pmc Attachment anxiety, relationship context, and sleep in women with recurrent major depression
    Wendy M Troxel
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Psychosom Med 69:692-9. 2007
    ..To examine the relationship between attachment anxiety, marital status, bed-partner status, and sleep in recurrently depressed women...
  81. pmc Examining initial sleep onset in primary insomnia: a case-control study using 4-second epochs
    Douglas E Moul
    University of Pittsburgh, Department of Psychiatry, Pittsburgh, PA, USA
    J Clin Sleep Med 3:479-88. 2007
    ..Conventional scorings in 20-second and 60-second epochs were also obtained...
  82. pmc Financial strain is a significant correlate of sleep continuity disturbances in late-life
    Martica Hall
    Department of Psychiatry, University of Pittsburgh School of Medicine, 3811 O Hara Street, Pittsburgh, PA 15213, United States
    Biol Psychol 77:217-22. 2008
    ..01). Our results show that chronic stress, as measured by ongoing financial strain, is a significant correlate of sleep disturbances in the elderly, even after adjusting for factors known to impact sleep in late-life...
  83. pmc Relationships between affect, vigilance, and sleepiness following sleep deprivation
    Peter L Franzen
    Department of Psychiatry, University of Pittsburgh School of Medicine, PA, USA
    J Sleep Res 17:34-41. 2008
    ..By including affective outcomes in experimental sleep deprivation research, the impact of sleep loss on affective function and their relationship to other neurobehavioral domains can be assessed...
  84. ncbi request reprint Self-reported sleep quality is associated with the metabolic syndrome
    J Richard Jennings
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA
    Sleep 30:219-23. 2007
    ..To determine whether a simple, structured self-report of overall sleep quality is associated with the presence of the metabolic syndrome and its component risk factors...
  85. pmc Diurnal variation in regional brain glucose metabolism in depression
    Anne Germain
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    Biol Psychiatry 62:438-45. 2007
    ..This study compared diurnal variation in mood and regional cerebral metabolic rate of glucose (rCMRglc) in depressed and healthy subjects...
  86. ncbi request reprint Psychological and behavioral treatment of insomnia:update of the recent evidence (1998-2004)
    Charles M Morin
    Universite Laval, Quebec, Canada
    Sleep 29:1398-414. 2006
    ..As with the original paper, this review was conducted by a task force commissioned by the American Academy of Sleep Medicine in order to update its practice parameters on psychological and behavioral therapies for insomnia...
  87. pmc Self-reported sleep duration is associated with the metabolic syndrome in midlife adults
    Martica H Hall
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Sleep 31:635-43. 2008
    ..In the present study, we evaluated the relationship between sleep duration and presence of the metabolic syndrome, which is a cluster of physiologically interrelated risk factors for cardiometabolic disease...
  88. ncbi request reprint Using daily 30-min phase advances to achieve a 6-hour advance: circadian rhythm, sleep, and alertness
    Timothy H Monk
    Clinical Neuroscience Research Center, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    Aviat Space Environ Med 77:677-86. 2006
    ..A ground-based study was undertaken to determine whether circadian and sleep dysfunction could be avoided by "trickling in" a 6-h phase advance in sleep/wake schedule by 12 consecutive 30-min phase advances as per NASA's Appendix K...
  89. ncbi request reprint Excessive daytime sleepiness in young adults: a 20-year prospective community study
    Gregor Hasler
    Mood and Anxiety Disorders Program, Intramural Research Program, National Institutes of Health, National Institute of Mental Health, Bethesda, MD 20892, USA
    J Clin Psychiatry 66:521-9. 2005
    ..The aim of this study was to explore associations between self-reported EDS, sleep disorder symptoms, major depression, and anxiety in a longitudinal community study of young adults...
  90. pmc Sleep-specific mechanisms underlying posttraumatic stress disorder: integrative review and neurobiological hypotheses
    Anne Germain
    Department of Psychiatry, University of Pittsburgh School of Medicine, 3811 O Hara Street, Room E 1124, Pittsburgh, PA 15213, USA
    Sleep Med Rev 12:185-95. 2008
    ..Testable hypotheses regarding the neurobiological underpinnings of PTSD across the sleep-wake cycle are offered...
  91. ncbi request reprint Regional cerebral metabolic correlates of WASO during NREM sleep in insomnia
    Eric A Nofzinger
    Western Psychiatric Institute and Clinic, Sleep Neuroimaging Research Program, Department of Psychiatry, University of Pittsburgh School of Medicine, 3811 O Hara Street, Pittsburgh, PA 15213 2593, USA
    J Clin Sleep Med 2:316-22. 2006
    ..To investigate the non-rapid eye movement (NREM) sleep-related regional cerebral metabolic correlates of wakefulness after sleep onset (WASO) in patients with primary insomnia...

Research Grants15

  1. 2/3-Improving Depression Outcome by Adding CBT for Insomnia to Antidepressants
    Daniel J Buysse; Fiscal Year: 2010
    ..The results of this study may offer a method for improving the treatment of major depression without the use of additional medication. ..
  2. Testing a Neurobiological Model of Primary Insomnia
    Daniel Buysse; Fiscal Year: 2009
    ..Results of this study could help us to better understand how the brain functions during sleep and wakefulness in people with insomnia, and how behavioral treatments (such as sleep restriction) might work. ..
  3. Testing a Neurobiological Model of Primary Insomnia
    Daniel Buysse; Fiscal Year: 2007
    ..Results of this study could help us to better understand how the brain functions during sleep and wakefulness in people with insomnia, and how behavioral treatments (such as sleep restriction) might work. ..
  4. Translational Research Training in Sleep Medicine
    Daniel Buysse; Fiscal Year: 2007
    ..The medical student research experiences are designed to stimulate interest in Sleep Medicine specifically, and to address the critical "pipeline" issue facing translational research in a more general sense. ..
  5. Psychobiology and Treatment Response in Primary Insomnia
    Daniel Buysse; Fiscal Year: 2006
    ..abstract_text> ..
  6. RATIONAL PHARMACOTHERAPY OF PRIMARY INSOMNIA
    Daniel Buysse; Fiscal Year: 2004
    ..The Principal Investigator will mentor trainees in analyses of existing data, design and implementation of the clinical trial, described above, and new studies designed by the trainees themselves. ..
  7. Testing a Neurobiological Model of Primary Insomnia
    Daniel J Buysse; Fiscal Year: 2010
    ..Results of this study could help us to better understand how the brain functions during sleep and wakefulness in people with insomnia, and how behavioral treatments (such as sleep restriction) might work. ..