Research Topics
Genomes and Genes
| Michael B ButterworthSummaryAffiliation: University of Pittsburgh Country: USA Publications
| Collaborators
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Detail Information
Publications
Rab11b regulates the trafficking and recycling of the epithelial sodium channel (ENaC)Michael B Butterworth
Department of Cell Biology and Physiology, University of Pittsburgh, Pittsburgh, PA 15261, USA
Am J Physiol Renal Physiol 302:F581-90. 2012..These data indicate that Rab11b, and to a lesser extent Rab11a, is involved in establishing the constitutive and cAMP-stimulated Na(+) transport in mpkCCD cells...- Acute ENaC stimulation by cAMP in a kidney cell line is mediated by exocytic insertion from a recycling channel poolMichael B Butterworth
Department of Cell Biology and Physiology, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA
J Gen Physiol 125:81-101. 2005..The model supports the concept of ENaC recycling in response to repetitive cAMP stimulation... 
PKA-dependent ENaC trafficking requires the SNARE-binding protein complexinM B Butterworth
Dept of Cell Biology and Physiology, University of Pittsburgh, PA 15261, USA
Am J Physiol Renal Physiol 289:F969-77. 2005....- Regulation of the epithelial sodium channel (ENaC) by membrane traffickingMichael B Butterworth
Department Cell Biology and Physiology, University of Pittsburgh, Pittsburgh, PA 15261, USA
Biochim Biophys Acta 1802:1166-77. 2010.... - The deubiquitinating enzyme UCH-L3 regulates the apical membrane recycling of the epithelial sodium channelMichael B Butterworth
Department of Cell Biology and Physiology, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA
J Biol Chem 282:37885-93. 2007..This constitutes a novel function for UCH in epithelia and in the regulation of ion channels and demonstrates the dynamic regulation of apically located ENaC by recycling, which is facilitated by this DUB... - Regulation of the epithelial sodium channel by membrane traffickingMichael B Butterworth
Dept of Cell Biology and Physiology, Univ of Pittsburgh, S375 BST, 3500 Terrace St, Pittsburgh, PA 15261, USA
Am J Physiol Renal Physiol 296:F10-24. 2009..While many details of the regulation of ENaC trafficking remain to be elucidated, knowledge of these mechanisms may provide further insights into ENaC activity in normal and disease states... - AS160 modulates aldosterone-stimulated epithelial sodium channel forward traffickingXiubin Liang
Department of Cell Biology and Physiology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
Mol Biol Cell 21:2024-33. 2010.... - An obligatory heterodimer of 14-3-3beta and 14-3-3epsilon is required for aldosterone regulation of the epithelial sodium channelXiubin Liang
Department of Cell Biology and Physiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
J Biol Chem 283:27418-25. 2008.... - Regulation of epithelial Na+ transport by soluble adenylyl cyclase in kidney collecting duct cellsKenneth R Hallows
Renal Electrolyte Division, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15621, USA
J Biol Chem 284:5774-83. 2009..In summary, these results suggest that sAC regulates both basal and agonist-stimulated Na(+) reabsorption in the kidney collecting duct, acting to enhance Na(+),K(+)-ATPase activity... - Rab11b regulates the apical recycling of the cystic fibrosis transmembrane conductance regulator in polarized intestinal epithelial cellsMark R Silvis
Department of Cell Biology and Physiology, University of Pittsburgh School of Medicine, PA 15261, USA
Mol Biol Cell 20:2337-50. 2009..This is the first report detailing apical CFTR recycling in a native expression system and to demonstrate that Rab11b regulates apical recycling in polarized epithelial cells... - Acute regulation of the epithelial sodium channel in airway epithelia by proteases and traffickingMICHAEL M MYERBURG
Division of Pulmonary, Allergy, and Critical Care Medicine, University of Pittsburgh Medical Center, Montefiore University Hospital, 3459 Fifth Ave, Pittsburgh, PA 15213, USA
Am J Respir Cell Mol Biol 43:712-9. 2010..These findings demonstrate that Na(+) absorption in the airway is acutely modulated by the coordinated trafficking of channels to the luminal surface and by the proteolytic activation of ENaC in response to ASL volume expansion... - Clathrin-mediated endocytosis of the epithelial sodium channel. Role of epsinHuamin Wang
Renal Electrolyte Division, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
J Biol Chem 281:14129-35. 2006..These results identify epsin as an accessory protein linking ENaC to the clathrin-based endocytic machinery thereby regulating the activity of this ion channel at the cell surface... - 14-3-3 isoforms are induced by aldosterone and participate in its regulation of epithelial sodium channelsXiubin Liang
Department of Cell Biology and Physiology, University of Pittsburgh School of Medicine, 3500 Terrace Street, Pittsburgh, PA 15261, USA
J Biol Chem 281:16323-32. 2006..Our studies show that aldosterone increases the expression of 14-3-3beta, which interacts with phospho-Nedd4-2 to block its interaction with ENaC, thus enhancing sodium absorption by increasing apical membrane ENaC density... - Activation of the epithelial sodium channel (ENaC) by the alkaline protease from Pseudomonas aeruginosaMichael B Butterworth
Department of Cell Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
J Biol Chem 287:32556-65. 2012..Based on these data, patho-mechanisms associated with AP in the CF lung are proposed wherein secretion of AP leads to decreased airway surface liquid volume and a corresponding decrease in mucocilliary clearance of pulmonary pathogens... - Airway surface liquid volume regulates ENaC by altering the serine protease-protease inhibitor balance: a mechanism for sodium hyperabsorption in cystic fibrosisMike M Myerburg
Division of Pulmonary, Allergy, and Critical Care Medicine, University of Pittsburgh, Pennsylvania 15213, USA
J Biol Chem 281:27942-9. 2006.... - Cysteine string protein monitors late steps in cystic fibrosis transmembrane conductance regulator biogenesisHui Zhang
Department of Cell Biology and Physiology, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
J Biol Chem 281:11312-21. 2006.... - The epithelial sodium channel (ENaC) establishes a trafficking vesicle pool responsible for its regulationRobert S Edinger
Department of Medicine, Renal Electrolyte Division, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
PLoS ONE 7:e46593. 2012..These findings indicate that ENaC is not a passive passenger in regulated epithelial vesicle trafficking, but plays a role in establishing and maintaining the pool of vesicles that respond to cAMP stimulation...