Michael B Butterworth

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. pmc Rab11b regulates the trafficking and recycling of the epithelial sodium channel (ENaC)
    Michael B Butterworth
    Department of Cell Biology and Physiology, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Am J Physiol Renal Physiol 302:F581-90. 2012
  2. pmc Acute ENaC stimulation by cAMP in a kidney cell line is mediated by exocytic insertion from a recycling channel pool
    Michael B Butterworth
    Department of Cell Biology and Physiology, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA
    J Gen Physiol 125:81-101. 2005
  3. ncbi PKA-dependent ENaC trafficking requires the SNARE-binding protein complexin
    M B Butterworth
    Dept of Cell Biology and Physiology, University of Pittsburgh, PA 15261, USA
    Am J Physiol Renal Physiol 289:F969-77. 2005
  4. pmc Regulation of the epithelial sodium channel (ENaC) by membrane trafficking
    Michael B Butterworth
    Department Cell Biology and Physiology, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Biochim Biophys Acta 1802:1166-77. 2010
  5. ncbi The deubiquitinating enzyme UCH-L3 regulates the apical membrane recycling of the epithelial sodium channel
    Michael B Butterworth
    Department of Cell Biology and Physiology, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA
    J Biol Chem 282:37885-93. 2007
  6. pmc Regulation of the epithelial sodium channel by membrane trafficking
    Michael B Butterworth
    Dept of Cell Biology and Physiology, Univ of Pittsburgh, S375 BST, 3500 Terrace St, Pittsburgh, PA 15261, USA
    Am J Physiol Renal Physiol 296:F10-24. 2009
  7. pmc AS160 modulates aldosterone-stimulated epithelial sodium channel forward trafficking
    Xiubin Liang
    Department of Cell Biology and Physiology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    Mol Biol Cell 21:2024-33. 2010
  8. pmc An obligatory heterodimer of 14-3-3beta and 14-3-3epsilon is required for aldosterone regulation of the epithelial sodium channel
    Xiubin Liang
    Department of Cell Biology and Physiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    J Biol Chem 283:27418-25. 2008
  9. pmc The epithelial sodium channel (ENaC) establishes a trafficking vesicle pool responsible for its regulation
    Robert S Edinger
    Department of Medicine, Renal Electrolyte Division, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
    PLoS ONE 7:e46593. 2012
  10. pmc Regulation of epithelial Na+ transport by soluble adenylyl cyclase in kidney collecting duct cells
    Kenneth R Hallows
    Renal Electrolyte Division, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15621, USA
    J Biol Chem 284:5774-83. 2009

Collaborators

Detail Information

Publications17

  1. pmc Rab11b regulates the trafficking and recycling of the epithelial sodium channel (ENaC)
    Michael B Butterworth
    Department of Cell Biology and Physiology, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Am J Physiol Renal Physiol 302:F581-90. 2012
    ..These data indicate that Rab11b, and to a lesser extent Rab11a, is involved in establishing the constitutive and cAMP-stimulated Na(+) transport in mpkCCD cells...
  2. pmc Acute ENaC stimulation by cAMP in a kidney cell line is mediated by exocytic insertion from a recycling channel pool
    Michael B Butterworth
    Department of Cell Biology and Physiology, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA
    J Gen Physiol 125:81-101. 2005
    ..The model supports the concept of ENaC recycling in response to repetitive cAMP stimulation...
  3. ncbi PKA-dependent ENaC trafficking requires the SNARE-binding protein complexin
    M B Butterworth
    Dept of Cell Biology and Physiology, University of Pittsburgh, PA 15261, USA
    Am J Physiol Renal Physiol 289:F969-77. 2005
    ....
  4. pmc Regulation of the epithelial sodium channel (ENaC) by membrane trafficking
    Michael B Butterworth
    Department Cell Biology and Physiology, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Biochim Biophys Acta 1802:1166-77. 2010
    ....
  5. ncbi The deubiquitinating enzyme UCH-L3 regulates the apical membrane recycling of the epithelial sodium channel
    Michael B Butterworth
    Department of Cell Biology and Physiology, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA
    J Biol Chem 282:37885-93. 2007
    ..This constitutes a novel function for UCH in epithelia and in the regulation of ion channels and demonstrates the dynamic regulation of apically located ENaC by recycling, which is facilitated by this DUB...
  6. pmc Regulation of the epithelial sodium channel by membrane trafficking
    Michael B Butterworth
    Dept of Cell Biology and Physiology, Univ of Pittsburgh, S375 BST, 3500 Terrace St, Pittsburgh, PA 15261, USA
    Am J Physiol Renal Physiol 296:F10-24. 2009
    ..While many details of the regulation of ENaC trafficking remain to be elucidated, knowledge of these mechanisms may provide further insights into ENaC activity in normal and disease states...
  7. pmc AS160 modulates aldosterone-stimulated epithelial sodium channel forward trafficking
    Xiubin Liang
    Department of Cell Biology and Physiology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    Mol Biol Cell 21:2024-33. 2010
    ....
  8. pmc An obligatory heterodimer of 14-3-3beta and 14-3-3epsilon is required for aldosterone regulation of the epithelial sodium channel
    Xiubin Liang
    Department of Cell Biology and Physiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    J Biol Chem 283:27418-25. 2008
    ....
  9. pmc The epithelial sodium channel (ENaC) establishes a trafficking vesicle pool responsible for its regulation
    Robert S Edinger
    Department of Medicine, Renal Electrolyte Division, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
    PLoS ONE 7:e46593. 2012
    ..These findings indicate that ENaC is not a passive passenger in regulated epithelial vesicle trafficking, but plays a role in establishing and maintaining the pool of vesicles that respond to cAMP stimulation...
  10. pmc Regulation of epithelial Na+ transport by soluble adenylyl cyclase in kidney collecting duct cells
    Kenneth R Hallows
    Renal Electrolyte Division, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15621, USA
    J Biol Chem 284:5774-83. 2009
    ..In summary, these results suggest that sAC regulates both basal and agonist-stimulated Na(+) reabsorption in the kidney collecting duct, acting to enhance Na(+),K(+)-ATPase activity...
  11. pmc Rab11b regulates the apical recycling of the cystic fibrosis transmembrane conductance regulator in polarized intestinal epithelial cells
    Mark R Silvis
    Department of Cell Biology and Physiology, University of Pittsburgh School of Medicine, PA 15261, USA
    Mol Biol Cell 20:2337-50. 2009
    ..This is the first report detailing apical CFTR recycling in a native expression system and to demonstrate that Rab11b regulates apical recycling in polarized epithelial cells...
  12. pmc Acute regulation of the epithelial sodium channel in airway epithelia by proteases and trafficking
    MICHAEL M MYERBURG
    Division of Pulmonary, Allergy, and Critical Care Medicine, University of Pittsburgh Medical Center, Montefiore University Hospital, 3459 Fifth Ave, Pittsburgh, PA 15213, USA
    Am J Respir Cell Mol Biol 43:712-9. 2010
    ..These findings demonstrate that Na(+) absorption in the airway is acutely modulated by the coordinated trafficking of channels to the luminal surface and by the proteolytic activation of ENaC in response to ASL volume expansion...
  13. ncbi Clathrin-mediated endocytosis of the epithelial sodium channel. Role of epsin
    Huamin Wang
    Renal Electrolyte Division, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    J Biol Chem 281:14129-35. 2006
    ..These results identify epsin as an accessory protein linking ENaC to the clathrin-based endocytic machinery thereby regulating the activity of this ion channel at the cell surface...
  14. ncbi 14-3-3 isoforms are induced by aldosterone and participate in its regulation of epithelial sodium channels
    Xiubin Liang
    Department of Cell Biology and Physiology, University of Pittsburgh School of Medicine, 3500 Terrace Street, Pittsburgh, PA 15261, USA
    J Biol Chem 281:16323-32. 2006
    ..Our studies show that aldosterone increases the expression of 14-3-3beta, which interacts with phospho-Nedd4-2 to block its interaction with ENaC, thus enhancing sodium absorption by increasing apical membrane ENaC density...
  15. pmc Activation of the epithelial sodium channel (ENaC) by the alkaline protease from Pseudomonas aeruginosa
    Michael B Butterworth
    Department of Cell Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    J Biol Chem 287:32556-65. 2012
    ..Based on these data, patho-mechanisms associated with AP in the CF lung are proposed wherein secretion of AP leads to decreased airway surface liquid volume and a corresponding decrease in mucocilliary clearance of pulmonary pathogens...
  16. ncbi Airway surface liquid volume regulates ENaC by altering the serine protease-protease inhibitor balance: a mechanism for sodium hyperabsorption in cystic fibrosis
    Mike M Myerburg
    Division of Pulmonary, Allergy, and Critical Care Medicine, University of Pittsburgh, Pennsylvania 15213, USA
    J Biol Chem 281:27942-9. 2006
    ....
  17. ncbi Cysteine string protein monitors late steps in cystic fibrosis transmembrane conductance regulator biogenesis
    Hui Zhang
    Department of Cell Biology and Physiology, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    J Biol Chem 281:11312-21. 2006
    ....