Research Topics
Species | Meryl ButtersSummaryAffiliation: University of Pittsburgh Country: USA Publications
Research Grants
| Collaborators
|
Detail Information
Publications
Late-life depression and risk of vascular dementia and Alzheimer's disease: systematic review and meta-analysis of community-based cohort studiesBreno S Diniz
PhD, Department of Psychiatry, University of Pittsburgh School of Medicine, 3811 O Hara Street, Pittsburgh, PA 15213, USA
Br J Psychiatry 202:329-35. 2013..Late-life depression may increase the risk of incident dementia, in particular of Alzheimer's disease and vascular dementia...
Imaging Alzheimer pathology in late-life depression with PET and Pittsburgh Compound-BMeryl A Butters
Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, Pittsburgh, PA 15213, USA
Alzheimer Dis Assoc Disord 22:261-8. 2008..Our findings are consistent with and supportive of the hypothesis that depression may herald the development of AD in some individuals...- Three-dimensional surface mapping of the caudate nucleus in late-life depressionMeryl A Butters
Department of Psychiatry, University of Pittsburgh, and Western Psychiatric Institute and Clinic, 3811 O Hara St, Pittsburgh, PA 15213, USA
Am J Geriatr Psychiatry 17:4-12. 2009.... - Pathways linking late-life depression to persistent cognitive impairment and dementiaMeryl A Butters
Department of Psychiatry, School of Medicine, University of Pittsburgh, Pennsylvania, USA
Dialogues Clin Neurosci 10:345-57. 2008.... 
Executive functioning, illness course, and relapse/recurrence in continuation and maintenance treatment of late-life depression: is there a relationship?Meryl A Butters
Intervention Research Center for Late Life Mood Disorders, Western Psychiatric Institute and Clinic, Department of Psychiatry, University of Pittsburgh Medical Center, USA
Am J Geriatr Psychiatry 12:387-94. 2004..The authors tested the hypothesis that impaired executive functioning leads to high rates of relapse and recurrence in late-life depression...- APOE is associated with age-of-onset, but not cognitive functioning, in late-life depressionMeryl A Butters
Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
Int J Geriatr Psychiatry 18:1075-81. 2003..We also predicted that APOE4 allele frequency would be increased among subjects with LLD... - Changes in neuropsychological functioning following treatment for late-life generalised anxiety disorderMeryl A Butters
Western Psychiatric Institute and Clinic, 3811 O Hara St, Pittsburgh, PA 15213, USA
Br J Psychiatry 199:211-8. 2011..Aims We examined neuropsychological functioning in older adults with GAD in comparison with psychiatrically healthy older adults at baseline, and we examined changes following a 12-week placebo-controlled trial of escitalopram... - Persistence of neuropsychologic deficits in the remitted state of late-life depressionRishi K Bhalla
Department of Psychiatry, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
Am J Geriatr Psychiatry 14:419-27. 2006..In addition, a substantial proportion of older depressed individuals who are cognitively intact when depressed are likely to be impaired one year later, although their depression has remitted... - Patterns of mild cognitive impairment after treatment of depression in the elderlyRishi K Bhalla
Department of Psychiatry, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
Am J Geriatr Psychiatry 17:308-16. 2009.... - fMRI activation in late-life anxious depression: a potential biomarkerCarmen Andreescu
Department of Psychiatry, The Advanced Center in Interventions and Services Research for Late Life Mood Disorders, University of Pittsburgh School of Medicine and the John A Hartford Center of Excellence in Geriatric Psychiatry, Pittsburgh, PA, USA
Int J Geriatr Psychiatry 24:820-8. 2009..Subjects were trained on the Preparing to Overcome Prepotency (POP) task, which is an executive control task that reliably activates the lateral prefrontal cortex-anterior cingulate cortex (ACC) cognitive control circuit... - Late-onset major depression: clinical and treatment-response variabilityHenry C Driscoll
Intervention Research Center for Late-Life Mood Disorders, Western Psychiatric Institute and Clinic, Pittsburgh, PA 15213, USA
Int J Geriatr Psychiatry 20:661-7. 2005..Further study of biological, neuropsychologic, and psychosocial correlates of late-onset, recurrent depression is needed... - Cognitive performance in suicidal depressed elderly: preliminary reportAlexandre Y Dombrovski
Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA
Am J Geriatr Psychiatry 16:109-15. 2008..This study examined cognitive function in general and executive functioning specifically in depressed elderly with and without suicidal ideation and attempts... - The nature and determinants of neuropsychological functioning in late-life depressionMeryl A Butters
Department of Psychiatry, University of Pittsburgh Medical Center, PA, USA
Arch Gen Psychiatry 61:587-95. 2004..Further studies of neuropsychological functioning in remitted LLD patients are needed to parse episode-related and persistent factors and to relate them to underlying neural dysfunction... - An open-label pilot study of acetylcholinesterase inhibitors to promote functional recovery in elderly cognitively impaired stroke patientsEllen M Whyte
Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63108, USA
Cerebrovasc Dis 26:317-21. 2008..We investigated the feasibility of using acetylcholinesterase inhibitors in older patients with acute post-stroke cognitive impairment and examined their effects on functional recovery... - Cognitive impairment in late-life generalized anxiety disorderRose C Mantella
Advanced Center in Interventions and Services Research for Late Life Mood Disorders and the John A Hartford Center of Excellence in Geriatric Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
Am J Geriatr Psychiatry 15:673-9. 2007..This study sought to characterize cognitive functioning in elderly patients with generalized anxiety disorder (GAD), as compared with normal comparison subjects and patients with major depression... - Cognitive impairment in acquired brain injury: a predictor of rehabilitation outcomes and an opportunity for novel interventionsEllen Whyte
Department of Psychiatry, School of Medicine, WPIC BT 764, 3811 O Hara St, Pittsburgh PA 15213, USA
PM R 3:S45-51. 2011..Furthermore, we examine nascent promising research that suggests that interventions that target cognitive impairments can lead to better rehabilitation outcomes... - A fully automated method for quantifying and localizing white matter hyperintensities on MR imagesMinjie Wu
Department of Electrical and Computer Engineering, University of Pittsburgh, USA
Psychiatry Res 148:133-42. 2006..Given the emergence of large NeuroImage databases, techniques, such as that described here, will allow for a better understanding of the relationship between WMHs and neuropsychiatric disorders... - Does education moderate neuropsychological impairment in late-life depression?Rishi K Bhalla
Intervention Research Center for the Study of Late Life Mood Disorders, Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, PA 15213, USA
Int J Geriatr Psychiatry 20:413-7. 2005..This study examined whether educational level influences the degree of neuropsychological impairment associated with late-life depression... - Comorbid anxiety disorder in late life depression: association with memory decline over four yearsAlison K DeLuca
The Intervention Research Center for Late-Life Mood Disorders, Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
Int J Geriatr Psychiatry 20:848-54. 2005..The data also suggest that anxiety disorders with an onset later in life may be associated with cognitive impairment, although further study is needed to confirm this finding... - Maintenance treatment of major depression in old ageCharles F Reynolds
Advanced Center for Intervention and Services Research for Late Life Mood Disorders, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, PA 15213, USA
N Engl J Med 354:1130-8. 2006..Elderly patients with major depression, including those having a first episode, are at high risk for recurrence of depression, disability, and death... - Neuropathologic correlates of late-onset major depressionRobert A Sweet
Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
Neuropsychopharmacology 29:2242-50. 2004..These preliminary findings suggest that AD is the predominant neuropathologic condition in LLMD subjects with dementia. Further assessment of the role of comorbid cerebrovascular disease and comorbid DLB is needed... - Altered functioning of the executive control circuit in late-life depression: episodic and persistent phenomenaHoward J Aizenstein
Department of Psychiatry, University of Pittsburgh, and Western Psychiatric Institute and Clinic, 3811 O Hara Street, Pittsburgh, PA 15213, USA
Am J Geriatr Psychiatry 17:30-42. 2009..To characterize the functional neuroanatomy of late-life depression (LLD) by probing for both episodic and persistent alterations in the executive-control circuit of elderly adults... - Cognitive functioning in late-life bipolar disorderAriel G Gildengers
Information Research Center for Late Life Mood Disorders, Department of Psychiatry, University of Pittsburgh School of Medicine, PA 15213, USA
Am J Psychiatry 161:736-8. 2004..This study characterized cognitive functioning in elderly patients with bipolar disorder... - Persistence of cognitive impairment in geriatric patients following antidepressant treatment: a randomized, double-blind clinical trial with nortriptyline and paroxetineRobert D Nebes
Intervention Research Center for the Study of Late Life Mood Disorders, Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
J Psychiatr Res 37:99-108. 2003..The present results suggest that cognitive dysfunction persists in older depressed patients even after their mood disorder has responded to antidepressant medications... - The longitudinal course of cognition in older adults with bipolar disorderAriel G Gildengers
Intervention Research Center for Late life Mood Disorders and the Advanced Center for Intervention and Services Research, Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
Bipolar Disord 11:744-52. 2009.... - Apathy after hip fracture: a potential target for intervention to improve functional outcomesEric J Lenze
Department of Psychiatry, Washington University School of Medicine, USA
J Neuropsychiatry Clin Neurosci 21:271-8. 2009..Interventions to prevent or improve apathy in elderly persons deserve further attention... - Treating depression to remission in older adults: a controlled evaluation of combined escitalopram with interpersonal psychotherapy versus escitalopram with depression care managementCharles F Reynolds
Department of Psychiatry, Advanced Center for Interventions and Services Research for Late Life Mood Disorders, Clinical Trials Management Unit, University of Pittsburgh School of Medicine, PA, USA
Int J Geriatr Psychiatry 25:1134-41. 2010.... - Maintenance treatment of depression in old age: a randomized, double-blind, placebo-controlled evaluation of the efficacy and safety of donepezil combined with antidepressant pharmacotherapyCharles F Reynolds
Department of Psychiatry, University of Pittsburgh, PA 15213, USA
Arch Gen Psychiatry 68:51-60. 2011..Cognitive impairment in late-life depression is a core feature of the illness... - Serotonin 1A receptor binding and treatment response in late-life depressionCarolyn Cidis Meltzer
Department of Radiology, University of Pittsburgh, Pittsburgh, PA, USA
Neuropsychopharmacology 29:2258-65. 2004..Further, this work indicates that dysfunction in autoreceptor activity may play a central role in the mechanisms underlying treatment response to selective serotonin reuptake inhibitors in late-life depression... - Salivary cortisol is associated with diagnosis and severity of late-life generalized anxiety disorderRose C Mantella
Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
Psychoneuroendocrinology 33:773-81. 2008..These data demonstrate HPA axis dysfunction in late-life GAD and suggest the need for additional research on the influence of aging on HPA axis function in mood and anxiety disorders... - Does depression, apathy or cognitive impairment reduce the benefit of inpatient rehabilitation facilities for elderly hip fracture patients?Eric J Lenze
Department of Psychiatry, University of Pittsburgh School of Medicine, Advanced Center for Interventions and Services Research in Late Life Mood Disorders and John A Hartford Center of Excellence in Geriatric Psychiatry, PA 15213, USA
Gen Hosp Psychiatry 29:141-6. 2007.... - Cognitive functioning and instrumental activities of daily living in late-life bipolar disorderAriel G Gildengers
Advanced Center for Intervention and Services Research for Late Life Disorders, Department of Psychiatry, Bipolar Disorder Center for Pennsylvanians, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
Am J Geriatr Psychiatry 15:174-9. 2007..The authors report on the relationship between cognitive functioning and instrumental activities of daily living (IADLs) in elderly, clinically euthymic adults with bipolar disorder... - Cognitive and behavioral correlates of low vitamin B12 levels in elderly patients with progressive dementiaEllen M Whyte
Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
Am J Geriatr Psychiatry 10:321-7. 2002..In AD, the prevalence of low vitamin B12 serum levels is consistent with that found in community-dwelling elderly persons in general but is associated with greater overall cognitive impairment... - A 12-week open-label pilot study of donepezil for cognitive functioning and instrumental activities of daily living in late-life bipolar disorderAriel G Gildengers
The Advanced Center for Intervention and Services Research, Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
Int J Geriatr Psychiatry 23:693-8. 2008..To determine whether donepezil is effective in enhancing cognitive functioning and instrumental activities of daily living (IADLs) in older adults with bipolar disorder... - The relationship between pain and mental flexibility in older adult pain clinic patientsJordan F Karp
Intervention Research Center and Advanced Center for Intervention and Services Research for Late Life Mood Disorders, University of Pittburgh School of Medicine, Pittsburgh, Pennsylvania, USA
Pain Med 7:444-52. 2006..Mental flexibility, memory, and information-processing speed may be particularly vulnerable in the aging brain. We investigated the effects of persistent pain on these cognitive domains among community-dwelling, nondemented older adults... - Body pain and treatment response in late-life depressionJordan F Karp
Western Psychiatric Institute and Clinic, 3811 O Hara St, Pittsburgh, PA 15213, USA
Am J Geriatr Psychiatry 13:188-94. 2005..They hypothesized that higher levels of body pain would predict a longer time to and lower likelihood of response, and increased levels of suicidal ideation... - Pilot study of augmentation with aripiprazole for incomplete response in late-life depression: getting to remissionMeera Sheffrin
Advanced Center in Interventions and Services Research for Late Life Mood Disorders ACISR LLMD and the John A Hartford Center of Excellence in Geriatric Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
J Clin Psychiatry 70:208-13. 2009.... - Reward/Punishment reversal learning in older suicide attemptersAlexandre Y Dombrovski
Western Psychiatric Institute and Clinic, Department of Psychiatry, University of Pittsburgh School of Medicine, USA
Am J Psychiatry 167:699-707. 2010..The authors further hypothesized that this impairment could be dissociated from executive abilities, such as forward planning... - Apathy and executive function in depressed elderlyRobert S Marin
The Intervention Research Center for the Study of Late Life Mood Disorders, Department of Psychiatry, University of Pittsburgh School of Medicine, Pennsylvania, USA
J Geriatr Psychiatry Neurol 16:112-6. 2003..Correlations may have been reduced by low variance for the variables of interest and by psychometric limitations of the ApHRSD... - Brain morphometric abnormalities in geriatric depression: long-term neurobiological effects of illness durationSandra Bell-McGinty
Neuropsychology Research Program, Department of Psychiatry, University of Pittsburgh Medical Center, PA 15213, USA
Am J Psychiatry 159:1424-7. 2002..CONCLUSIONS: These data provide further evidence of structural brain abnormalities in geriatric depression, particularly in patients with a longer course of illness... - Impact of close family members on older adults' early response to depression treatmentLynn M Martire
Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15260, USA
Psychol Aging 23:447-52. 2008..Future research may identify family attitudes and behaviors that stem from burden and compromise older adults' ability to recover from depression... - Cognitive and affective predictors of rehabilitation participation after strokeElizabeth R Skidmore
Department of Occupational Therapy, University of Pittsburgh, Pittsburgh, PA, USA
Arch Phys Med Rehabil 91:203-7. 2010..To examine associations between cognitive and affective impairments and rehabilitation participation during stroke rehabilitation... - Comparisons of methods for multiple hypothesis testing in neuropsychological researchRichard E Blakesley
Department of Biostatistics, University of Pittsburgh, PA, USA
Neuropsychology 23:255-64. 2009..The authors note caveats regarding the implementation of these methods using available software... - Predicting 6-week treatment response to escitalopram pharmacotherapy in late-life major depressive disorderRamin Saghafi
Western Psychiatric Institute and Clinic, Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, USA
Int J Geriatr Psychiatry 22:1141-6. 2007..This study aims to characterize sociodemographic, clinical, and neuropsychologic correlates of full, partial, and non-response to escitalopram monotherapy of unipolar MDD in later life... - Escitalopram for older adults with generalized anxiety disorder: a randomized controlled trialEric J Lenze
Department of Psychiatry, Washington University School of Medicine, 660 S Euclid, Box 8134, St Louis, MO 63110, USA
JAMA 301:295-303. 2009..Selective serotonin reuptake inhibitors (SSRIs) are efficacious for younger adults with GAD, but benefits and risks may be different in older adults... - Prefrontal and striatal activation during sequence learning in geriatric depressionHoward J Aizenstein
Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
Biol Psychiatry 58:290-6. 2005..The aim of the present study was to test this hypothesis with the use of functional magnetic resonance imaging (fMRI) tasks that are known to engage the prefrontal and neostriatal cognitive circuits... - Gray matter changes in late life depression--a structural MRI analysisCarmen Andreescu
The Advanced Center for Interventions and Services Research for Late life Mood Disorders, Department of Psychiatry, University of Pittsburgh School of Medicine and the John A Hartford Center of Excellence in Geriatric Psychiatry, Pittsburgh, PA 15213, USA
Neuropsychopharmacology 33:2566-72. 2008..However, it remains likely that both processes as well as other factors contribute to the heterogeneity of volumetric brain changes in LLD... - Amygdalae morphometry in late-life depressionRobert J Tamburo
Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA
Int J Geriatr Psychiatry 24:837-46. 2009.... - The BOLD hemodynamic response in healthy agingHoward J Aizenstein
University of Pittsburgh School of Medicine, PA, USA
J Cogn Neurosci 16:786-93. 2004..g., inclusion of low-significance and/or negative voxels) underscores the importance of ROI selection criteria in the interpretation of fMRI studies using elderly populations... - Prefrontal and striatal activation in elderly subjects during concurrent implicit and explicit sequence learningHoward J Aizenstein
Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Department of Psychiatry, 3811 O Hara Street, Pittsburgh, PA 15213, USA
Neurobiol Aging 27:741-51. 2006..Moreover, these changes are observed during an implicit task, and thus do not seem to be mediated by awareness... - Perspectives on depression, mild cognitive impairment, and cognitive declineDavid C Steffens
Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, NC 27710, USA
Arch Gen Psychiatry 63:130-8. 2006....
Research Grants
- COURSE OF COGNITIVE FUNCTIONING IN LATE LIFE DEPRESSIONMeryl Butters; Fiscal Year: 2004..This award will provide the applicant with the resources to obtain the training necessary to initiate a line of programmatic research and to develop into an independent scientist. ..
- Amyloid, white matter hyperintensities & outcomes of late-life depressionMeryl A Butters; Fiscal Year: 2010....
- Pathways Linking Late-Life Depression to MCI & DementiaMeryl Butters; Fiscal Year: 2009....
- Amyloid, white matter hyperintensities & outcomes of late-life depressionMeryl Butters; Fiscal Year: 2009....
- Pathways Linking Late-Life Depression to MCI & DementiaMeryl Butters; Fiscal Year: 2007....
- Pathways Linking Late-Life Depression to MCI & DementiaMeryl Butters; Fiscal Year: 2009....