RONALD BUTOW

Summary

Affiliation: University of Texas Southwestern Medical Center
Country: USA

Publications

  1. ncbi request reprint Mitochondrial signaling: the retrograde response
    Ronald A Butow
    Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Mol Cell 14:1-15. 2004
  2. ncbi request reprint Cellular responses to mitochondrial dysfunction: it's not always downhill
    R A Butow
    Department of Molecular Biology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, Texas TX 75390 9148, USA
    Cell Death Differ 9:1043-5. 2002
  3. pmc RTG-dependent mitochondria-to-nucleus signaling is regulated by MKS1 and is linked to formation of yeast prion [URE3]
    Takayuki Sekito
    Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9148, USA
    Mol Biol Cell 13:795-804. 2002
  4. pmc A novel degron-mediated degradation of the RTG pathway regulator, Mks1p, by SCFGrr1
    Zhengchang Liu
    Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9148, USA
    Mol Biol Cell 16:4893-904. 2005
  5. ncbi request reprint Retrograde response to mitochondrial dysfunction is separable from TOR1/2 regulation of retrograde gene expression
    Sergio Giannattasio
    Department of Molecular Biology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 9148, USA
    J Biol Chem 280:42528-35. 2005
  6. ncbi request reprint The organization and inheritance of the mitochondrial genome
    Xin Jie Chen
    Department of Molecular Biology, University of Texas Southwestern Medical Center, 6000 Harry Hines Boulevard, Dallas, Texas 75390 9148, USA
    Nat Rev Genet 6:815-25. 2005
  7. ncbi request reprint Mitochondrial retrograde signaling
    Zhengchang Liu
    Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9148, USA
    Annu Rev Genet 40:159-85. 2006
  8. pmc Yeast aconitase binds and provides metabolically coupled protection to mitochondrial DNA
    Xin Jie Chen
    Department of Molecular Biology, University of Texas Southwestern Medical Center at Dallas, 6000 Harry Hines Boulevard, Dallas, TX 75390, USA
    Proc Natl Acad Sci U S A 104:13738-43. 2007
  9. ncbi request reprint Evolutionary tinkering with mitochondrial nucleoids
    Martin Kucej
    Department of Molecular Biology, University of Texas Southwestern Medical Center, 6000 Harry Hines Boulevard, Dallas, TX 75390 9148, USA
    Trends Cell Biol 17:586-92. 2007
  10. pmc Activation of the SPS amino acid-sensing pathway in Saccharomyces cerevisiae correlates with the phosphorylation state of a sensor component, Ptr3
    Zhengchang Liu
    Department of Biological Sciences, University of New Orleans, New Orleans, LA 70148, USA
    Mol Cell Biol 28:551-63. 2008

Research Grants

Collaborators

Detail Information

Publications23

  1. ncbi request reprint Mitochondrial signaling: the retrograde response
    Ronald A Butow
    Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Mol Cell 14:1-15. 2004
    ..Retrograde signaling also induces invasive behavior in otherwise nontumorigenic cells implying a role in tumor progression...
  2. ncbi request reprint Cellular responses to mitochondrial dysfunction: it's not always downhill
    R A Butow
    Department of Molecular Biology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, Texas TX 75390 9148, USA
    Cell Death Differ 9:1043-5. 2002
  3. pmc RTG-dependent mitochondria-to-nucleus signaling is regulated by MKS1 and is linked to formation of yeast prion [URE3]
    Takayuki Sekito
    Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9148, USA
    Mol Biol Cell 13:795-804. 2002
    ..We find that glutamate suppresses [URE3] formation, suggesting that the Mks1p effect on the formation of [URE3] can occur indirectly via regulation of the RTG pathway...
  4. pmc A novel degron-mediated degradation of the RTG pathway regulator, Mks1p, by SCFGrr1
    Zhengchang Liu
    Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9148, USA
    Mol Biol Cell 16:4893-904. 2005
    ..We propose that Mks1p is a central player of RS and is acted upon by multiple regulators of the pathway...
  5. ncbi request reprint Retrograde response to mitochondrial dysfunction is separable from TOR1/2 regulation of retrograde gene expression
    Sergio Giannattasio
    Department of Molecular Biology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 9148, USA
    J Biol Chem 280:42528-35. 2005
    ....
  6. ncbi request reprint The organization and inheritance of the mitochondrial genome
    Xin Jie Chen
    Department of Molecular Biology, University of Texas Southwestern Medical Center, 6000 Harry Hines Boulevard, Dallas, Texas 75390 9148, USA
    Nat Rev Genet 6:815-25. 2005
    ..These findings provide new insights into the mechanisms of mtDNA maintenance and inheritance...
  7. ncbi request reprint Mitochondrial retrograde signaling
    Zhengchang Liu
    Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9148, USA
    Annu Rev Genet 40:159-85. 2006
    ..Here we review advances in the yeast retrograde signaling pathway and highlight its regulatory factors and regulatory mechanisms, its physiological functions, and its connection to nutrient sensing, TOR signaling, and aging...
  8. pmc Yeast aconitase binds and provides metabolically coupled protection to mitochondrial DNA
    Xin Jie Chen
    Department of Molecular Biology, University of Texas Southwestern Medical Center at Dallas, 6000 Harry Hines Boulevard, Dallas, TX 75390, USA
    Proc Natl Acad Sci U S A 104:13738-43. 2007
    ..Therefore, mitochondria are opportunistic organelles that seize proteins, such as metabolic enzymes, for construction of the nucleoid, an mtDNA maintenance/segregation apparatus...
  9. ncbi request reprint Evolutionary tinkering with mitochondrial nucleoids
    Martin Kucej
    Department of Molecular Biology, University of Texas Southwestern Medical Center, 6000 Harry Hines Boulevard, Dallas, TX 75390 9148, USA
    Trends Cell Biol 17:586-92. 2007
    ....
  10. pmc Activation of the SPS amino acid-sensing pathway in Saccharomyces cerevisiae correlates with the phosphorylation state of a sensor component, Ptr3
    Zhengchang Liu
    Department of Biological Sciences, University of New Orleans, New Orleans, LA 70148, USA
    Mol Cell Biol 28:551-63. 2008
    ..Our findings reveal that CKI and PP2A phosphatase play antagonistic roles in SPS sensing by regulating Ptr3 phosphorylation...
  11. pmc SIT4 regulation of Mig1p-mediated catabolite repression in Saccharomyces cerevisiae
    Can Jin
    Department of Biological Sciences, Columbia University, New York, NY 10027, USA
    FEBS Lett 581:5658-63. 2007
    ..Our evidence suggests that this pathway involves turnover of Mig1p...
  12. ncbi request reprint Interaction between Rtg2p and Mks1p in the regulation of the RTG pathway of Saccharomyces cerevisiae
    Jose Ribamar Ferreira Junior
    Department of Molecular Biology, University of Texas Southwestern Medical Center, 6000 Harry Hines Blvd, Dallas, TX 75390 9148, USA
    Gene 354:2-8. 2005
    ..Together, our data suggest that dynamic association between Mks1p and Rtg2p in high molecular weight complexes provides a means to regulate the RTG pathway...
  13. ncbi request reprint Aconitase couples metabolic regulation to mitochondrial DNA maintenance
    Xin Jie Chen
    Department of Molecular Biology, University of Texas Southwestern Medical Center, 6000 Harry Hines Boulevard, Dallas, TX 75390 9148, USA
    Science 307:714-7. 2005
    ..When constitutively expressed, Aco1p can replace the mtDNA packaging function of the high-mobility-group protein Abf2p. Thus, Aco1p may integrate metabolic signals and mtDNA maintenance...
  14. doi request reprint Mitochondrial nucleoids undergo remodeling in response to metabolic cues
    Martin Kucej
    Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9148, USA
    J Cell Sci 121:1861-8. 2008
    ..A mutant form of Hsp60 that causes mtDNA instability has altered submitochondrial localization, which suggests that nucleoid remodeling is essential for the maintenance of mitochondrial genome...
  15. ncbi request reprint Crosslinking of proteins to mtDNA
    Brett A Kaufman
    Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX, USA
    Methods Mol Biol 197:377-89. 2002
  16. pmc Mutational bisection of the mitochondrial DNA stability and amino acid biosynthetic functions of ilv5p of budding yeast
    Joseph M Bateman
    Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9148, USA
    Genetics 161:1043-52. 2002
    ....
  17. ncbi request reprint Mitochondrial DNA instability mutants of the bifunctional protein Ilv5p have altered organization in mitochondria and are targeted for degradation by Hsp78 and the Pim1p protease
    Joseph M Bateman
    Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9148, USA
    J Biol Chem 277:47946-53. 2002
    ....
  18. pmc Global transcription analysis of Krebs tricarboxylic acid cycle mutants reveals an alternating pattern of gene expression and effects on hypoxic and oxidative genes
    Mark T McCammon
    Department of Biochemistry, University of Texas Health Science Center at San Antonio, 78229 3900, USA
    Mol Biol Cell 14:958-72. 2003
    ..These studies have revealed extensive responses to changes in TCA cycle function and have uncovered new and unexpected metabolic networks that are wired into the TCA cycle...
  19. ncbi request reprint ATO3 encoding a putative outward ammonium transporter is an RTG-independent retrograde responsive gene regulated by GCN4 and the Ssy1-Ptr3-Ssy5 amino acid sensor system
    Nicoletta Guaragnella
    Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9148, USA
    J Biol Chem 278:45882-7. 2003
    ..We propose that ATO3 is induced in rhoo cells to eliminate the excess ammonia that arises because of a potential defect in ammonia assimilation in those cells...
  20. ncbi request reprint Retrograde signaling is regulated by the dynamic interaction between Rtg2p and Mks1p
    Zhengchang Liu
    Department of Molecular Biology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
    Mol Cell 12:401-11. 2003
    ..Point mutations in the Rtg2p ATP binding domain simultaneously block RS and Mks1p-Rtg2p interaction. We propose that activation of RS via mitochondrial dysfunction and TOR inhibition intersect at the Rtg2p-Mks1p switch...
  21. pmc A function for the mitochondrial chaperonin Hsp60 in the structure and transmission of mitochondrial DNA nucleoids in Saccharomyces cerevisiae
    Brett A Kaufman
    Department of Molecular Biology, The University of Texas Southwestern Medical Center, Dallas, TX 75390 9148, USA
    J Cell Biol 163:457-61. 2003
    ..Our data suggest that the nucleoid dynamics underlying mtDNA transmission are regulated by the interaction between Hsp60 and mtDNA ori sequences...
  22. ncbi request reprint Cross-hybridization on PCR-spotted microarrays
    Jonathan D Wren
    IEEE Eng Med Biol Mag 21:71-5. 2002
  23. ncbi request reprint Alterations of O-glycosylation, cell wall, and mitochondrial metabolism in Kluyveromyces lactis cells defective in KlPmr1p, the Golgi Ca(2+)-ATPase
    Francesca Farina
    Department of Developmental and Cell Biology, University of Rome La Sapienza, Piazza Aldo Moro 5, 00185 Rome, Italy
    Biochem Biophys Res Commun 318:1031-8. 2004
    ..Increases in oxygen consumption and succinate dehydrogenase activity were also observed in mutant cells. The described approach highlighted the unexpected involvement of KlPMR1 in energy-yielding processes...

Research Grants23

  1. ORGANIZATION, EXPRESSION, AND INHERITANCE OF YEAST MTDNA
    RONALD BUTOW; Fiscal Year: 2003
    ..It is now clear that a number of inherited disorders involve aspects of the segregation of mutant and wild-type mtDNAs. The investigators have developed a tractable experimental system in which to investigate these important issues. ..
  2. GENETIC AND MOLECULAR STUDIES OF GROUP II INTRONS
    RONALD BUTOW; Fiscal Year: 2004
    ..Finally, the RNA binding and splicing functions of the naturase domain of the intron-encoded protein will be studied. ..
  3. ORGANIZATION, EXPRESSION, AND INHERITANCE OF YEAST MTDNA
    RONALD BUTOW; Fiscal Year: 2007
    ..These studies will be coupled with the analysis of cis-acting elements that distinguish active from inactive ori elements. Altogether, these studies have direct implications for understanding mitochondrial diseases in humans. ..
  4. YEAST MITOCHONDRIAL DNA RECOMBINATION
    RONALD BUTOW; Fiscal Year: 1993
    ..Mutant screens will be undertaken aimed at defining nuclear genes that participate in mitochondrial segregation...
  5. ORGANIZATION, EXPRESSION, AND INHERITANCE OF YEAST MTDNA
    RONALD BUTOW; Fiscal Year: 1999
    ..We have developed a tractable experimental system in which to investigate these important issues. ..
  6. REGULATION OF MITOCHONDRIAL BIOGENESIS IN YEAST
    RONALD BUTOW; Fiscal Year: 2007
    ..These experiments should provide additional insights into the function of retrograde regulation...