John E Butler

Summary

Affiliation: University of Iowa
Country: USA

Publications

  1. pmc Antibody repertoire development in fetal and neonatal piglets. XVI. Influenza stimulates adaptive immunity, class switch and diversification of the IgG repertoire encoded by downstream Cγ genes
    John E Butler
    Department of Microbiology, Carver College of Medicine, Iowa City, IA 52240, USA
    Immunology 138:134-44. 2013
  2. ncbi Antibody repertoire development in fetal and neonatal piglets: XIX. Undiversified B cells with hydrophobic HCDR3s preferentially proliferate in the porcine reproductive and respiratory syndrome
    John E Butler
    Department of Microbiology and Interdisciplinary Immunology Program, University of Iowa, Iowa City, IA 52242, USA
    J Immunol 178:6320-31. 2007
  3. ncbi Porcine reproductive and respiratory syndrome virus subverts repertoire development by proliferation of germline-encoded B cells of all isotypes bearing hydrophobic heavy chain CDR3
    John E Butler
    Department of Microbiology, University of Iowa Medical School, 51 Newton Road, Iowa City, IA 52242, USA
    J Immunol 180:2347-56. 2008
  4. pmc Antibody repertoire development in fetal and neonatal piglets. XI. The thymic B-cell repertoire develops independently from that in blood and mesenteric lymph nodes
    Jeremy McAleer
    Department of Microbiology, The University of Iowa, Iowa City, IA 52242 1109, USA
    Immunology 114:171-83. 2005
  5. ncbi Antibody repertoire development in fetal and neonatal piglets. XIII. Hybrid VH genes and the preimmune repertoire revisited
    John E Butler
    Department of Microbiology, University of Iowa, Iowa City, IA 52242, USA
    J Immunol 177:5459-70. 2006
  6. pmc Antibody repertoire development in fetal and neonatal piglets. XXII. λ Rearrangement precedes κ rearrangement during B-cell lymphogenesis in swine
    Xiuzhu Sun
    Department of Microbiology and Interdisciplinary Immunology Program, University of Iowa College of Medicine, Iowa City, IA, USA
    Immunology 137:149-59. 2012
  7. pmc Comparison of the expressed porcine Vbeta and Jbeta repertoire of thymocytes and peripheral T cells
    John E Butler
    Department of Microbiology, The University of Iowa, Iowa City, IA 52242 1109, USA
    Immunology 114:184-93. 2005
  8. doi Antibody repertoire development in fetal and neonatal piglets. XII. Three IGLV genes comprise 70% of the pre-immune repertoire and there is little junctional diversity
    Nancy Wertz
    Department of Microbiology, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA
    Mol Immunol 55:319-28. 2013
  9. ncbi Antibody repertoire development in fetal and neonatal piglets. XVII. IgG subclass transcription revisited with emphasis on new IgG3
    John E Butler
    Department of Microbiology and Interdisciplinary Immunology Program, University of Iowa, Iowa City, IA 52242, USA
    J Immunol 177:5480-9. 2006
  10. ncbi Antibody repertoire development in fetal and neonatal piglets. IX. Three pathogen-associated molecular patterns act synergistically to allow germfree piglets to respond to type 2 thymus-independent and thymus-dependent antigens
    John E Butler
    Department of Microbiology and Interdisciplinary Immunology Program, University of Iowa, Iowa City, IA 52242, USA
    J Immunol 175:6772-85. 2005

Collaborators

Detail Information

Publications21

  1. pmc Antibody repertoire development in fetal and neonatal piglets. XVI. Influenza stimulates adaptive immunity, class switch and diversification of the IgG repertoire encoded by downstream Cγ genes
    John E Butler
    Department of Microbiology, Carver College of Medicine, Iowa City, IA 52240, USA
    Immunology 138:134-44. 2013
    ..Whereas IgG3 may play an initial protective role, antibodies encoded by downstream Cγ genes with diversified repertoires are predicted to be most important in long-term protection against S-FLU...
  2. ncbi Antibody repertoire development in fetal and neonatal piglets: XIX. Undiversified B cells with hydrophobic HCDR3s preferentially proliferate in the porcine reproductive and respiratory syndrome
    John E Butler
    Department of Microbiology and Interdisciplinary Immunology Program, University of Iowa, Iowa City, IA 52242, USA
    J Immunol 178:6320-31. 2007
    ..We speculate that PRRSV infection generates a product that engages the BCR of naive B cells, displaying the AMVLV and similar motifs in HCDR3 and resulting in their T-independent proliferation without repertoire diversification...
  3. ncbi Porcine reproductive and respiratory syndrome virus subverts repertoire development by proliferation of germline-encoded B cells of all isotypes bearing hydrophobic heavy chain CDR3
    John E Butler
    Department of Microbiology, University of Iowa Medical School, 51 Newton Road, Iowa City, IA 52242, USA
    J Immunol 180:2347-56. 2008
    ..This diversion from normal repertoire development may explain the delayed immune response to PRRSV...
  4. pmc Antibody repertoire development in fetal and neonatal piglets. XI. The thymic B-cell repertoire develops independently from that in blood and mesenteric lymph nodes
    Jeremy McAleer
    Department of Microbiology, The University of Iowa, Iowa City, IA 52242 1109, USA
    Immunology 114:171-83. 2005
    ....
  5. ncbi Antibody repertoire development in fetal and neonatal piglets. XIII. Hybrid VH genes and the preimmune repertoire revisited
    John E Butler
    Department of Microbiology, University of Iowa, Iowa City, IA 52242, USA
    J Immunol 177:5459-70. 2006
    ..One-third of these genes are chimeric genes and their sequences suggest that the porcine VH genome developed by duplication and splicing from a small number of prototypic genes...
  6. pmc Antibody repertoire development in fetal and neonatal piglets. XXII. λ Rearrangement precedes κ rearrangement during B-cell lymphogenesis in swine
    Xiuzhu Sun
    Department of Microbiology and Interdisciplinary Immunology Program, University of Iowa College of Medicine, Iowa City, IA, USA
    Immunology 137:149-59. 2012
    ..Based on recovery of SJC, B-cell lymphogenesis continues for at least 5 weeks postpartum...
  7. pmc Comparison of the expressed porcine Vbeta and Jbeta repertoire of thymocytes and peripheral T cells
    John E Butler
    Department of Microbiology, The University of Iowa, Iowa City, IA 52242 1109, USA
    Immunology 114:184-93. 2005
    ..7 usage. These studies show that unlike porcine heavy chain V(H) genes, the occurrence and relative usage of porcine TCR-Vbeta groups resembles that of humans. Thus, highly related gene systems can individually diverge within a species...
  8. doi Antibody repertoire development in fetal and neonatal piglets. XII. Three IGLV genes comprise 70% of the pre-immune repertoire and there is little junctional diversity
    Nancy Wertz
    Department of Microbiology, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA
    Mol Immunol 55:319-28. 2013
    ..7 and did not change in GF piglets. Similar to the heavy chain pre-immune repertoire in this species, three IGLV genes account for ~70% of the repertoire. Unlike the heavy chain repertoire, junctional diversity was very limited...
  9. ncbi Antibody repertoire development in fetal and neonatal piglets. XVII. IgG subclass transcription revisited with emphasis on new IgG3
    John E Butler
    Department of Microbiology and Interdisciplinary Immunology Program, University of Iowa, Iowa City, IA 52242, USA
    J Immunol 177:5480-9. 2006
    ..We hypothesize that long-hinged porcine IgG3 may be important in preadaptive responses to T cell-independent Ags similar to those described for its murine namesake...
  10. ncbi Antibody repertoire development in fetal and neonatal piglets. IX. Three pathogen-associated molecular patterns act synergistically to allow germfree piglets to respond to type 2 thymus-independent and thymus-dependent antigens
    John E Butler
    Department of Microbiology and Interdisciplinary Immunology Program, University of Iowa, Iowa City, IA 52242, USA
    J Immunol 175:6772-85. 2005
    ....
  11. ncbi Development of the neonatal B and T cell repertoire in swine: implications for comparative and veterinary immunology
    John E Butler
    Department of Microbiology and Interdisciplinary Immunology Program, The University of Iowa, Iowa City, 52242, USA
    Vet Res 37:417-41. 2006
    ..Improper development of adaptive immunity can be caused by infectious agents like the porcine reproductive and respiratory syndrome virus that causes immune dysregulation resulting in immunological injury and autoimmunity...
  12. doi Antibody repertoire development in fetal and neonatal piglets. XV. Porcine circovirus type 2 infection differentially affects serum IgG levels and antibodies to ORF2 in piglets free from other environmental factors
    Xiuzhu Sun
    Department of Microbiology, Carver College of Medicine, Iowa City, IA, United States
    Vaccine 31:141-8. 2012
    ..In any case, developers may have to contend with significant genetic differences in the response of piglets to PCV2...
  13. doi Antibody repertoire development in fetal and neonatal piglets. XX. B cell lymphogenesis is absent in the ileal Peyer's patches, their repertoire development is antigen dependent, and they are not required for B cell maintenance
    John E Butler
    Department of Microbiology, University of Iowa, Iowa City, IA 52242, USA
    J Immunol 187:5141-9. 2011
    ....
  14. doi Antibody repertoire development in fetal and neonatal piglets XXI. Usage of most VH genes remains constant during fetal and postnatal development
    John E Butler
    Department of Microbiology, Carver College of Medicine, University of Iowa, Iowa City, IA, USA
    Mol Immunol 49:483-94. 2011
    ..Therefore in swine a small number of VH genes shape the antibody repertoire throughout life questioning the need for extensive VH polygeny...
  15. ncbi Antibody repertoire development in swine
    John E Butler
    Department of Microbiology, The University of Iowa, Iowa City, IA 52242, USA
    Dev Comp Immunol 30:199-221. 2006
    ..Swine exemplify a situation in which evolutionary diversification of the immune system is not characteristic of an entire order or even of other related systems in the same species...
  16. ncbi Lymphoid hyperplasia resulting in immune dysregulation is caused by porcine reproductive and respiratory syndrome virus infection in neonatal pigs
    Caitlin D Lemke
    Interdisciplinary Graduate Program in Immunology, University of Iowa, Iowa City, IA 52242, USA
    J Immunol 172:1916-25. 2004
    ....
  17. ncbi Antibody repertoire development in fetal and neonatal pigs. VII. Characterization of the preimmune kappa light chain repertoire
    John E Butler
    Department of Microbiology and Interdisciplinary Immunology Program, University of Iowa, Iowa City, IA 52242, USA
    J Immunol 173:6794-805. 2004
    ..These studies, like those of porcine Ig constant regions and MHC genes, also indicate unexpected high sequence similarity with their human counterparts despite differences in phylogeny and the mechanism of repertoire diversification...
  18. doi The two suborders of chiropterans have the canonical heavy-chain immunoglobulin (Ig) gene repertoire of eutherian mammals
    John E Butler
    Department of Microbiology, University of Iowa, Iowa City, IA 52242, USA
    Dev Comp Immunol 35:273-84. 2011
    ..Data reveal that CH diversity and VDJ and CDR3 organization are similar to other eutherian mammals, although the expressed VH3 family repertoire was unusually diverse...
  19. ncbi Antibody repertoire development in fetal and neonatal piglets. VIII. Colonization is required for newborn piglets to make serum antibodies to T-dependent and type 2 T-independent antigens
    John E Butler
    Department of Microbiology and Interdisciplinary Immunology Program, University of Iowa, Iowa City, IA 52242 1109, USA
    J Immunol 169:6822-30. 2002
    ..We further propose that Ag-driven systemic responses require both bacterial colonization and TD Ags translocated to the peritoneum...
  20. ncbi Solid supports in enzyme-linked immunosorbent assay and other solid-phase immunoassays
    John E Butler
    Department of Microbiology, Interdisciplinary Immunology Training Program, The University of Iowa, Iowa City, USA
    Methods Mol Med 94:333-72. 2004
    ..Empiricism, adherence to a few practical rules of thumb, and avoidance of certain "old wives tales" can be valuable in the successful development of SPIs...
  21. pmc The porcine antibody repertoire: variations on the textbook theme
    John E Butler
    Department of Microbiology, Carver College of Medicine, University of Iowa Iowa City, IA, USA
    Front Immunol 3:153. 2012
    ..In swine we believe such duplications within the genome have very limited functional significance and their occurrence is therefore overrated...