J Scott Butler

Summary

Affiliation: University of Rochester
Country: USA

Publications

  1. pmc Evidence for core exosome independent function of the nuclear exoribonuclease Rrp6p
    Kevin P Callahan
    Department of Biochemistry and Biophysics, University of Rochester Medical Center, Rochester, NY 14642, USA
    Nucleic Acids Res 36:6645-55. 2008
  2. pmc Lifting the veil on the transcriptome
    Kevin P Callahan
    Department of Biochemistry and Biophysics, University of Rochester Medical Center, Elmwood Avenue, Rochester, NY 14642, USA
    Genome Biol 9:218. 2008
  3. ncbi The yin and yang of the exosome
    J Scott Butler
    Dept of Microbiology and Immunology, University of Rochester School of Medicine and Dentistry, Box 672 601, Elmwood Ave, Rochester, NY 14642, USA
    Trends Cell Biol 12:90-6. 2002
  4. pmc Rat1p and Rai1p function with the nuclear exosome in the processing and degradation of rRNA precursors
    Feng Fang
    Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY 14642, USA
    RNA 11:1571-8. 2005
  5. pmc Regulation of NAB2 mRNA 3'-end formation requires the core exosome and the Trf4p component of the TRAMP complex
    Kelly M Roth
    Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, New York 14642, USA
    RNA 15:1045-58. 2009
  6. pmc TRAMP complex enhances RNA degradation by the nuclear exosome component Rrp6
    Kevin P Callahan
    Department of Biochemistry and Biophysics, University of Rochester Medical Center, Rochester, New York 14642, USA
    J Biol Chem 285:3540-7. 2010
  7. pmc 5-fluorouracil enhances exosome-dependent accumulation of polyadenylated rRNAs
    Feng Fang
    Department of Microbiology and Immunology, Box 672, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Mol Cell Biol 24:10766-76. 2004
  8. pmc Polyadenylation of rRNA in Saccharomyces cerevisiae
    Letian Kuai
    Department of Biochemistry and Biophysics, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Proc Natl Acad Sci U S A 101:8581-6. 2004
  9. pmc RNA-based 5-fluorouracil toxicity requires the pseudouridylation activity of Cbf5p
    Jason Hoskins
    Department of Biochemistry and Biophysics, University of Rochester Medical Center, Rochester, NY 14642, USA
    Genetics 179:323-30. 2008
  10. pmc The nuclear exosome contributes to autogenous control of NAB2 mRNA levels
    Kelly M Roth
    Department of Microbiology and Immunology, University of Rochester School of Medicine and Dentistry, Box 672, 601 Elmwood Ave, Rochester, NY 14642, USA
    Mol Cell Biol 25:1577-85. 2005

Collaborators

  • Fred Sherman
  • Phil Mitchell
  • Kevin P Callahan
  • Feng Fang
  • Karyn Schmidt
  • Kelly M Roth
  • Jason Hoskins
  • Ashfaqul Alam
  • Seasson Phillips
  • Letian Kuai
  • Biswadip Das
  • David H Mathews
  • Zhenjiang Xu
  • Michelle Dziejman
  • Mudit Chaand
  • Kelly A Miller
  • Joel Byam
  • Maria K Wolf
  • Marie Rossi

Detail Information

Publications17

  1. pmc Evidence for core exosome independent function of the nuclear exoribonuclease Rrp6p
    Kevin P Callahan
    Department of Biochemistry and Biophysics, University of Rochester Medical Center, Rochester, NY 14642, USA
    Nucleic Acids Res 36:6645-55. 2008
    ..These findings indicate that Rrp6p may carry out some of its critical functions without physical association with the core exosome...
  2. pmc Lifting the veil on the transcriptome
    Kevin P Callahan
    Department of Biochemistry and Biophysics, University of Rochester Medical Center, Elmwood Avenue, Rochester, NY 14642, USA
    Genome Biol 9:218. 2008
    ..This normally hidden transcriptome is replete with noncoding RNAs with the potential to regulate wide-ranging physiological activities...
  3. ncbi The yin and yang of the exosome
    J Scott Butler
    Dept of Microbiology and Immunology, University of Rochester School of Medicine and Dentistry, Box 672 601, Elmwood Ave, Rochester, NY 14642, USA
    Trends Cell Biol 12:90-6. 2002
    ..How the cell regulates the nucleolytic prowess of the exosome to ensure correct and timely synthesis and destruction of RNAs is a central focus of current research...
  4. pmc Rat1p and Rai1p function with the nuclear exosome in the processing and degradation of rRNA precursors
    Feng Fang
    Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY 14642, USA
    RNA 11:1571-8. 2005
    ..These findings suggest that Rai1p may coordinate the 5'-end and 3'-end processing and degradation activities of Rat1p and the nuclear exosome...
  5. pmc Regulation of NAB2 mRNA 3'-end formation requires the core exosome and the Trf4p component of the TRAMP complex
    Kelly M Roth
    Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, New York 14642, USA
    RNA 15:1045-58. 2009
    ..These findings suggest that NAB2 mRNA 3'-end formation requires the exosome and TRAMP complex, and that competition between polyadenylation and Rrp6p-dependent degradation controls the level of this mRNA...
  6. pmc TRAMP complex enhances RNA degradation by the nuclear exosome component Rrp6
    Kevin P Callahan
    Department of Biochemistry and Biophysics, University of Rochester Medical Center, Rochester, New York 14642, USA
    J Biol Chem 285:3540-7. 2010
    ..These findings identify TRAMP as an exosome-independent enhancer of Rrp6 activity...
  7. pmc 5-fluorouracil enhances exosome-dependent accumulation of polyadenylated rRNAs
    Feng Fang
    Department of Microbiology and Immunology, Box 672, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Mol Cell Biol 24:10766-76. 2004
    ..These findings suggest that 5FU inhibits an exosome-dependent surveillance pathway that degrades polyadenylated precursor rRNAs...
  8. pmc Polyadenylation of rRNA in Saccharomyces cerevisiae
    Letian Kuai
    Department of Biochemistry and Biophysics, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Proc Natl Acad Sci U S A 101:8581-6. 2004
    ..For at least one rRNA type, the polyadenylation preferentially occurs on the precursor rather than the mature product. The existence of polyadenylated rRNAs may reflect a quality-control mechanism of rRNA biogenesis...
  9. pmc RNA-based 5-fluorouracil toxicity requires the pseudouridylation activity of Cbf5p
    Jason Hoskins
    Department of Biochemistry and Biophysics, University of Rochester Medical Center, Rochester, NY 14642, USA
    Genetics 179:323-30. 2008
    ....
  10. pmc The nuclear exosome contributes to autogenous control of NAB2 mRNA levels
    Kelly M Roth
    Department of Microbiology and Immunology, University of Rochester School of Medicine and Dentistry, Box 672, 601 Elmwood Ave, Rochester, NY 14642, USA
    Mol Cell Biol 25:1577-85. 2005
    ..These findings suggest a novel regulatory circuit in which the nuclear exosome controls the level of NAB2 mRNA in response to changes in the activity of Nab2 protein...
  11. pmc Air proteins control differential TRAMP substrate specificity for nuclear RNA surveillance
    Karyn Schmidt
    Department of Biochemistry and Biophysics, University of Rochester Medical Center, Rochester, New York 14642, USA
    RNA 18:1934-45. 2012
    ..These findings reveal differential functions for Air proteins in RNA metabolism and indicate that they control the substrate specificity of the RNA exosome...
  12. pmc Contribution of domain structure to the RNA 3' end processing and degradation functions of the nuclear exosome subunit Rrp6p
    Seasson Phillips
    Department of Microbiology and Immunology, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    RNA 9:1098-107. 2003
    ..In contrast, this mutant retains the ability to degrade rRNA processing intermediates and 3'-extended, poly(A)+ snoRNAs. These findings indicate the potential for independent control of the processing and degradation functions of Rrp6p...
  13. pmc Degradation of normal mRNA in the nucleus of Saccharomyces cerevisiae
    Biswadip Das
    Department of Biochemistry and Biophysics, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    Mol Cell Biol 23:5502-15. 2003
    ..We propose that certain normal mRNAs retained in the nucleus are degraded by the DRN system, similar to degradation of transcripts with 3' end formation defects in certain mutants...
  14. ncbi Rrp6, Rrp47 and cofactors of the nuclear exosome
    J Scott Butler
    Department of Microbiology and Immunology, Center for RNA Biology from Genome to Medicine, University of Rochester Medical Center, Rochester, New York, USA
    Adv Exp Med Biol 702:91-104. 2010
    ..The details that govern the specificity of these decisions remain a rich source for future investigation...
  15. pmc Nuclear RNA surveillance: role of TRAMP in controlling exosome specificity
    Karyn Schmidt
    Department of Biochemistry and Biophysics, Center for RNA Biology, University of Rochester Medical Center, Rochester, NY, USA
    Wiley Interdiscip Rev RNA 4:217-31. 2013
    ..This review summarizes recent findings on the nuclear RNA surveillance complexes, and speculates upon possible mechanisms for TRAMP-mediated substrate recognition and exosome activation...
  16. pmc Identification of Vibrio cholerae type III secretion system effector proteins
    Ashfaqul Alam
    Department of Microbiology and Immunology, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA
    Infect Immun 79:1728-40. 2011
    ..The collective results show that the V. cholerae T3SS encodes multiple effector proteins, one of which likely has novel activities that contribute to disease via interference with eukaryotic signaling pathways...
  17. doi Rrp6, rrp47 and cofactors of the nuclear exosome
    J Scott Butler
    Departments of Microbiology and Immunology, and Biochemistry and Biophysics, and Center for RNA Biology from Genome to Medicine, University of Rochester Medical Center, Rochester, New York, USA
    Adv Exp Med Biol 702:91-104. 2011
    ..The details that govern the specificity of these decisions remain a rich source for future investigation...