David Butler

Summary

Affiliation: University of Cincinnati
Country: USA

Publications

  1. pmc Evolving strategies in mechanobiology to more effectively treat damaged musculoskeletal tissues
    David L Butler
    Tissue Engineering and Biomechanics Laboratories, Biomedical Engineering Program, College of Engineering and Applied Sciences, University of Cincinnati Cincinnati, OH 45221, USA
    J Biomech Eng 135:020301. 2013
  2. doi request reprint The use of mesenchymal stem cells in collagen-based scaffolds for tissue-engineered repair of tendons
    David L Butler
    Department of Biomedical Engineering, Colleges of Engineering and Medicine, University of Cincinnati, Cincinnati, Ohio, USA
    Nat Protoc 5:849-63. 2010
  3. pmc Using functional tissue engineering and bioreactors to mechanically stimulate tissue-engineered constructs
    David L Butler
    Department of Biomedical Engineering, Colleges of Engineering and Medicine, University of Cincinnati, Cincinnati, Ohio 45221 0048, USA
    Tissue Eng Part A 15:741-9. 2009
  4. ncbi request reprint Functional tissue engineering for tendon repair: A multidisciplinary strategy using mesenchymal stem cells, bioscaffolds, and mechanical stimulation
    David L Butler
    Department of Biomedical Engineering, 840 Engineering Research Center, Colleges of Engineering and Medicine, University of Cincinnati, 2901 Woodside Drive, Cincinnati, Ohio 45221 0048, USA
    J Orthop Res 26:1-9. 2008
  5. ncbi request reprint Functional efficacy of tendon repair processes
    David L Butler
    Department of Biomedical Engineering, Noyes Giannestras Biomechanics Laboratory, University of Cincinnati, Cincinnati, Ohio 45221 0048, USA
    Annu Rev Biomed Eng 6:303-29. 2004
  6. ncbi request reprint Effects of cell-to-collagen ratio in mesenchymal stem cell-seeded implants on tendon repair biomechanics and histology
    Natalia Juncosa-Melvin
    Noyes Tissue Engineering and Biomechanics Laboratories, Department of Biomedical Engineering, University of Cincinnati, OH 45221, USA
    Tissue Eng 11:448-57. 2005
  7. pmc A role for hedgehog signaling in the differentiation of the insertion site of the patellar tendon in the mouse
    Chia Feng Liu
    Division of Developmental Biology, Cincinnati Children s Hospital Research Foundation, Cincinnati, Ohio, United States of America
    PLoS ONE 8:e65411. 2013
  8. ncbi request reprint The effect of autologous mesenchymal stem cells on the biomechanics and histology of gel-collagen sponge constructs used for rabbit patellar tendon repair
    Natalia Juncosa-Melvin
    Department of Biomedical Engineering, University of Cincinnati, Ohio, USA
    Tissue Eng 12:369-79. 2006
  9. doi request reprint Effect of scaffold material, construct length and mechanical stimulation on the in vitro stiffness of the engineered tendon construct
    Victor S Nirmalanandhan
    Department of Biomedical Engineering, University of Cincinnati, Cincinnati, OH 45221 0048, USA
    J Biomech 41:822-8. 2008
  10. pmc Spatial and temporal expression of molecular markers and cell signals during normal development of the mouse patellar tendon
    Chia Feng Liu
    Division of Developmental Biology, Cincinnati Children s Hospital Research Foundation, Cincinnati, OH 45229, USA
    Tissue Eng Part A 18:598-608. 2012

Collaborators

Detail Information

Publications34

  1. pmc Evolving strategies in mechanobiology to more effectively treat damaged musculoskeletal tissues
    David L Butler
    Tissue Engineering and Biomechanics Laboratories, Biomedical Engineering Program, College of Engineering and Applied Sciences, University of Cincinnati Cincinnati, OH 45221, USA
    J Biomech Eng 135:020301. 2013
    ..Hopefully, these retrospective and prospective analyses will be useful as the ASME Bioengineering Division charts future research directions...
  2. doi request reprint The use of mesenchymal stem cells in collagen-based scaffolds for tissue-engineered repair of tendons
    David L Butler
    Department of Biomedical Engineering, Colleges of Engineering and Medicine, University of Cincinnati, Cincinnati, Ohio, USA
    Nat Protoc 5:849-63. 2010
    ..The in vivo portion, from TEC implantation to limb harvest, takes 84 d. One complete loop around the tissue engineering road map, as presented here, takes 138 d to complete...
  3. pmc Using functional tissue engineering and bioreactors to mechanically stimulate tissue-engineered constructs
    David L Butler
    Department of Biomedical Engineering, Colleges of Engineering and Medicine, University of Cincinnati, Cincinnati, Ohio 45221 0048, USA
    Tissue Eng Part A 15:741-9. 2009
    ..Future bioreactors could be further improved by controlling and measuring TEC displacements and forces to create more functional tissues for surgeons and their patients...
  4. ncbi request reprint Functional tissue engineering for tendon repair: A multidisciplinary strategy using mesenchymal stem cells, bioscaffolds, and mechanical stimulation
    David L Butler
    Department of Biomedical Engineering, 840 Engineering Research Center, Colleges of Engineering and Medicine, University of Cincinnati, 2901 Woodside Drive, Cincinnati, Ohio 45221 0048, USA
    J Orthop Res 26:1-9. 2008
    ..Our contributions in the area of tendon functional tissue engineering have the potential to create functional load-bearing repairs that will revolutionize surgical reconstruction after tendon and ligament injury...
  5. ncbi request reprint Functional efficacy of tendon repair processes
    David L Butler
    Department of Biomedical Engineering, Noyes Giannestras Biomechanics Laboratory, University of Cincinnati, Cincinnati, Ohio 45221 0048, USA
    Annu Rev Biomed Eng 6:303-29. 2004
    ..The paper concludes with future directions...
  6. ncbi request reprint Effects of cell-to-collagen ratio in mesenchymal stem cell-seeded implants on tendon repair biomechanics and histology
    Natalia Juncosa-Melvin
    Noyes Tissue Engineering and Biomechanics Laboratories, Department of Biomedical Engineering, University of Cincinnati, OH 45221, USA
    Tissue Eng 11:448-57. 2005
    ..Current repairs achieved higher maximum forces than in previous studies and without ectopic bone, but will need to achieve sufficient stiffness as well to be effective in the in vivo range of loading...
  7. pmc A role for hedgehog signaling in the differentiation of the insertion site of the patellar tendon in the mouse
    Chia Feng Liu
    Division of Developmental Biology, Cincinnati Children s Hospital Research Foundation, Cincinnati, Ohio, United States of America
    PLoS ONE 8:e65411. 2013
    ..These studies provide new insights into the role of Hh signaling during tendon development...
  8. ncbi request reprint The effect of autologous mesenchymal stem cells on the biomechanics and histology of gel-collagen sponge constructs used for rabbit patellar tendon repair
    Natalia Juncosa-Melvin
    Department of Biomedical Engineering, University of Cincinnati, Ohio, USA
    Tissue Eng 12:369-79. 2006
    ..This study shows that introducing autogenous mesenchymal stem cells into a gel-collagen sponge composite significantly improves tendon repair compared to the use of a gel-sponge composite alone in the range of in vivo loading...
  9. doi request reprint Effect of scaffold material, construct length and mechanical stimulation on the in vitro stiffness of the engineered tendon construct
    Victor S Nirmalanandhan
    Department of Biomedical Engineering, University of Cincinnati, Cincinnati, OH 45221 0048, USA
    J Biomech 41:822-8. 2008
    ....
  10. pmc Spatial and temporal expression of molecular markers and cell signals during normal development of the mouse patellar tendon
    Chia Feng Liu
    Division of Developmental Biology, Cincinnati Children s Hospital Research Foundation, Cincinnati, OH 45229, USA
    Tissue Eng Part A 18:598-608. 2012
    ..These data will allow both the functional analysis of specific signaling pathways in tenocyte development and their application to tissue-engineering studies in vitro...
  11. ncbi request reprint Effects of cell seeding density and collagen concentration on contraction kinetics of mesenchymal stem cell-seeded collagen constructs
    Victor S Nirmalanandhan
    Department of Biomedical Engineering, University of Cincinnati, Cincinnati, Ohio 45221 0048, USA
    Tissue Eng 12:1865-72. 2006
    ..Controlling scaffold as well as cellular initial conditions will be critical in achieving our goal of functional tissue engineering (FTE) a successful tendon repair...
  12. ncbi request reprint Effects of cell-to-collagen ratio in stem cell-seeded constructs for Achilles tendon repair
    Natalia Juncosa-Melvin
    Noyes Tissue Engineering and Biomechanics Laboratories, Department of Biomedical Engineering, University of Cincinnati, Ohio 45221 0048, USA
    Tissue Eng 12:681-9. 2006
    ....
  13. ncbi request reprint Effects of matrix stabilization when using glutaraldehyde on the material properties of porcine meniscus
    Shawn A Hunter
    Noyes Giannestras Biomechanics Laboratories, Department of Biomedical Engineering, 860 Engineering Research Center, University of Cincinnati, Cincinnati, Ohio 45221 0048, USA
    J Biomed Mater Res A 67:1245-54. 2003
    ..02% resulted in tissues with material properties no different from the untreated controls. We conclude that minimal concentrations of glutaraldehyde (less than 0.2%) should be used in future studies to preserve normal meniscus properties...
  14. ncbi request reprint In vivo forces used to develop design parameters for tissue engineered implants for rabbit patellar tendon repair
    Natalia Juncosa
    Noyes Giannestras Biomechanics Laboratories, Department of Biomedical Engineering, University of Cincinnati, 2901 Campus Drive, P O Box 210048, Cincinnati, OH 45221 0048, USA
    J Biomech 36:483-8. 2003
    ..001). Such design criteria should be useful in mechanically stimulating cell-gel constructs for tendon repair...
  15. ncbi request reprint Effects of mechanical stimulation on the biomechanics and histology of stem cell-collagen sponge constructs for rabbit patellar tendon repair
    Natalia Juncosa-Melvin
    Department of Biomedical Engineering, University of Cincinnati, Cincinnati, Ohio 45221 0048, USA
    Tissue Eng 12:2291-300. 2006
    ..This study shows that mechanical stimulation of stem cell-collagen sponge constructs can significantly improve tendon repair biomechanics up to and well beyond the functional limits of in vivo loading...
  16. doi request reprint Improving linear stiffness of the cell-seeded collagen sponge constructs by varying the components of the mechanical stimulus
    Victor S Nirmalanandhan
    Department of Biomedical Engineering, University of Cincinnati, Cincinnati, OH, USA
    Tissue Eng Part A 14:1883-91. 2008
    ..Given the significant positive correlations we have previously found between construct stiffness and repair biomechanics at 12 weeks post-surgery, these in vitro enhancements offer the prospect of further improving repair biomechanics...
  17. ncbi request reprint Repair of patellar tendon injuries using a cell-collagen composite
    Hani A Awad
    Noyes Giannestras Biomechanics Laboratories, Department of Biomedical Engineering, University of Cincinnati, 2901 Campus Drive, P O Box 210048, OH 45221 0048, USA
    J Orthop Res 21:420-31. 2003
    ....
  18. pmc What we should know before using tissue engineering techniques to repair injured tendons: a developmental biology perspective
    Chia Feng Liu
    Division of Developmental Biology, Cincinnati Children s Hospital Research Foundation, Cincinnati, Ohio 45229, USA
    Tissue Eng Part B Rev 17:165-76. 2011
    ..Here we review studies focusing on the developmental mechanisms of tendon development, and discuss the potential applications of a molecular understanding of tendon development to the treatment of tendon injuries...
  19. pmc Effect of surgery to implant motion and force sensors on vertical ground reaction forces in the ovine model
    Safa T Herfat
    Department of Biomedical Engineering, Tissue Engineering and Biomechanics Laboratories, University of Cincinnati, Mail Location 0048, Cincinnati, OH 45221 0048, USA
    J Biomech Eng 133:021010. 2011
    ..Ultimately, we seek to measure ACL forces for ADLs to provide design criteria and evaluation benchmarks for traditional and tissue engineered ACL repairs and reconstructions...
  20. pmc Chondroitin-6-sulfate incorporation and mechanical stimulation increase MSC-collagen sponge construct stiffness
    Kirsten R C Kinneberg
    Tissue Engineering and Biomechanics Laboratories, Department of Biomedical Engineering, University of Cincinnati, 2901 Campus Drive, ML0048, Cincinnati, Ohio 45221 0048, USA
    J Orthop Res 28:1092-9. 2010
    ..C6S incorporation and cycle number each played an important role in gene expression, but only the interaction of C6S incorporation and cycle number produced a benefit for TEC linear stiffness...
  21. doi request reprint Uniaxial strain regulates morphogenesis, gene expression, and tissue strength in engineered skin
    Heather M Powell
    Research Department, Shriners Burns Hospital, Cincinnati, Ohio, USA
    Tissue Eng Part A 16:1083-92. 2010
    ..These improvements to ES may facilitate surgical application, prevent damage during transplantation, and may result in improved functional outcomes after engraftment...
  22. ncbi request reprint Mechanical stimulation increases collagen type I and collagen type III gene expression of stem cell-collagen sponge constructs for patellar tendon repair
    Natalia Juncosa-Melvin
    Department of Biomedical Engineering, University of Cincinnati, Cincinnati, Ohio 45221 0048, USA
    Tissue Eng 13:1219-26. 2007
    ..2) after 14 days in culture. This study shows that mechanical stimulation of cell-sponge constructs produces similar increases in the expression of 2 structural genes, as well as linear stiffness and linear modulus...
  23. ncbi request reprint Meniscal material properties are minimally affected by matrix stabilization using glutaraldehyde and glycation with ribose
    Shawn A Hunter
    Noyes Giannestras Biomechanics Laboratories, Department of Biomedical Engineering, University of Cincinnati, 893 Engineering Research Center, OH 45221 0048, USA
    J Orthop Res 23:555-61. 2005
    ..Further research is necessary to determine whether these treatments prevent enzymatic degradation before and after surgical implantation in the knee...
  24. ncbi request reprint Mechanical stimulation of tissue engineered tendon constructs: effect of scaffold materials
    Victor S Nirmalanandhan
    Department of Biomedical Engineering, University of Cincinnati, 2901 Campus Drive, 837 Engineering Research Center, Cincinnati, OH 45221 0048, USA
    J Biomech Eng 129:919-23. 2007
    ....
  25. ncbi request reprint Mechanical stimulation of tendon tissue engineered constructs: effects on construct stiffness, repair biomechanics, and their correlation
    Jason T Shearn
    Tissue Engineering and Biomechanics Laboratories, Department of Biomedical Engineering, University of Cincinnati, Mail Location 0048, Cincinnati, OH 45221 0048, USA
    J Biomech Eng 129:848-54. 2007
    ..56) as were their linear moduli (r=0.68). Such in vitro predictors of in vivo outcome hold the potential to speed the development of tissue engineered products by reducing the time and costs of in vivo studies...
  26. ncbi request reprint Effect of length of the engineered tendon construct on its structure-function relationships in culture
    Victor S Nirmalanandhan
    Department of Biomedical Engineering, University of Cincinnati, 2901 Woodside Drive, 827 Engineering Research Center, Cincinnati, OH 45221 0048, USA
    J Biomech 40:2523-9. 2007
    ..0404). We now plan to use principles of functional tissue engineering to determine if repairs containing central regions of longer MSC-collagen constructs improve defect repair biomechanics after implantation at surgery...
  27. pmc Three-dimensional in vitro effects of compression and time in culture on aggregate modulus and on gene expression and protein content of collagen type II in murine chondrocytes
    Kumar Chokalingam
    Department of Biomedical Engineering, University of Cincinnati, Cincinnati, Ohio 45221 0048, USA
    Tissue Eng Part A 15:2807-16. 2009
    ..Future studies will examine the effects of components of the mechanical signal in culture and address the question of whether such in vitro improvements in tissue-engineered constructs enhance repair outcomes after surgery...
  28. ncbi request reprint Characterization of in vivo Achilles tendon forces in rabbits during treadmill locomotion at varying speeds and inclinations
    John R West
    Noyes Giannestras Biomechanics Laboratories, Department of Biomedical Engineering, University of Cincinnati, Cincinnati, OH 45221 0041, USA
    J Biomech 37:1647-53. 2004
    ..Force patterns can also serve as input data for mechanical stimulation of tissue-engineered constructs in culture. Such approaches are expected to help accelerate tendon repair after injury...
  29. ncbi request reprint The effect of gamma irradiation on anterior cruciate ligament allograft biomechanical and biochemical properties in the caprine model at time zero and at 6 months after surgery
    Herbert E Schwartz
    Noyes Tissue Engineering and Biomechanics Laboratories, Department of Biomedical Engineering, University of Cincinnati, Ohio, USA
    Am J Sports Med 34:1747-55. 2006
    ..The effects of high levels of gamma irradiation on anterior cruciate ligament allograft biomechanics are still not known...
  30. pmc Structural and biomechanical responses of osseous healing: a novel murine nonunion model
    Aditya Chaubey
    Biomedical Engineering Program, School of Energy, Environmental and Biological and Medical Engineering, University of Cincinnati, 2901 Woodside Dr, Cincinnati, OH, 45221 0048, USA
    J Orthop Traumatol 14:247-57. 2013
    ..In this study, we report the results of a recently established model for creating critical defects that lead to atrophic nonunions based on a unique fracture fixation technique...
  31. pmc The impact of biomechanics in tissue engineering and regenerative medicine
    David L Butler
    Biomedical Engineering, University of Cincinnati, Cincinnati, Ohio, USA
    Tissue Eng Part B Rev 15:477-84. 2009
    ..This paper reviews the present role and potential impact of experimental and computational biomechanics in engineering functional tissues using several illustrative examples of past successes and future grand challenges...
  32. pmc Tensile stimulation of murine stem cell-collagen sponge constructs increases collagen type I gene expression and linear stiffness
    Kumar Chokalingam
    Department of Biomedical Engineering, University of Cincinnati, Cincinnati, Ohio 45221 0048, USA
    Tissue Eng Part A 15:2561-70. 2009
    ..Future studies will vary the mechanical signal to optimize type I collagen gene expression to improve construct biomechanics and in vivo tendon repair...
  33. doi request reprint Accessing the tissue engineering literature: a new paradigm
    Abhishek Jain
    Department of Biomedical Engineering, University of Cincinnati, Cincinnati, Ohio 45221 0048, USA
    Tissue Eng Part A 14:459-60. 2008
  34. ncbi request reprint Structural and mechanical properties of the glenohumeral joint posterior capsule
    Michael J Bey
    Henry Ford Health System, Bone and Joint Center, Detroit, MI, USA
    J Shoulder Elbow Surg 14:201-6. 2005
    ..2), maximum stress (P=.46), or strain energy density (P=.62). Specimens failed primarily near the glenoid insertion (75%), with 4 specimens failing at the humeral insertion and 2 others failing in the tissue's mid substance...

Research Grants15

  1. A Developmentally-Based Tissue Engineering Approach to Improve Tendon Repair
    David L Butler; Fiscal Year: 2010
    ....
  2. "In Vitro Mechanical Stimulation to Enhance Tendon Repair"
    David Butler; Fiscal Year: 2009
    ..Our novel, interactive in vitro / in vivo study should help to develop in vitro predictors of in vivo repair outcome after surgery that also apply to other tissue systems. ..
  3. Tissue Engineering Evaluation Criteria for Musculoskeletal Tissue Repair
    David Butler; Fiscal Year: 2007
    ..abstract_text> ..
  4. "In Vitro Mechanical Stimulation to Enhance Tendon Repair"
    David Butler; Fiscal Year: 2007
    ..Our novel, interactive in vitro / in vivo study should help to develop in vitro predictors of in vivo repair outcome after surgery that also apply to other tissue systems. ..
  5. Robotic Simulation: Tissue Function with In Vivo Motions
    David Butler; Fiscal Year: 2007
    ..These technologies will serve as a platform for studying injury, repair and reconstruction in the knee and other joints and to develop functional tissue engineering parameters. ..
  6. Cell phenotype-controlled mechanical signaling of MSCs
    David Butler; Fiscal Year: 2004
    ..This technology can dramatically reduce time/expense during the development phase of TE fibrocartilage. ..
  7. FUNCTIONAL TISSUE ENGINEERING FOR TENDON REPAIR
    David Butler; Fiscal Year: 2004
    ..7. Identify possible predictors of in vivo outcome by correlating in vitro biomechanical, histological, and biochemical results with early and long-term in vivo outcomes. ..
  8. A Developmentally-Based Tissue Engineering Approach to Improve Tendon Repair
    David L Butler; Fiscal Year: 2010
    ..is among four faculty in the Department of Biomedical Engineering at the University of Cincinnati (David Butler, PhD, and Jason Shearn, PhD, tissue engineers and Professor and Assistant Professor, respectively;Mary Beth ..