Research Topics
| J BustilloSummaryAffiliation: University of New Mexico Country: USA Publications
Research Grants
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Detail Information
Publications
High choline concentrations in the caudate nucleus in antipsychotic-naive patients with schizophreniaJuan R Bustillo
Department of Psychiatry, University of New Mexico School of Medicine, 87131, USA
Am J Psychiatry 159:130-3. 2002..Proton magnetic resonance spectroscopy ((1)H-MRS) studies of medicated patients with schizophrenia suggest high choline levels in the caudate nucleus. However, assessments of antipsychotic-naive patients are needed...
Medial-frontal cortex hypometabolism in chronic phencyclidine exposed rats assessed by high resolution magic angle spin 11.7 T proton magnetic resonance spectroscopyJuan Bustillo
Department of Psychiatry, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA
Neurochem Int 61:128-31. 2012....- Glutamate as a marker of cognitive function in schizophrenia: a proton spectroscopic imaging study at 4 TeslaJuan R Bustillo
Department of Psychiatry, University of New Mexico, Albuquerque, New Mexico, USA
Biol Psychiatry 69:19-27. 2011..We examined the relationship between glutamate metabolism and cognitive function in schizophrenia... - 1H-MRS at 4 tesla in minimally treated early schizophreniaJ R Bustillo
Department of Psychiatry, University of New Mexico, Albuquerque, NM 87131 0001, USA
Mol Psychiatry 15:629-36. 2010..We conclude that early in the illness, schizophrenia patients already show abnormalities in glutamatergic metabolism and reductions in NAA consistent with glutamate-related excitotoxicity... - Proton magnetic resonance spectroscopy during initial treatment with antipsychotic medication in schizophreniaJuan R Bustillo
Department of Psychiatry, University of New Mexico, Albuquerque, NM 87131 0001, USA
Neuropsychopharmacology 33:2456-66. 2008..Early in the illness, schizophrenia patients already demonstrate subtle reductions in NAA. Treatment with typical or atypical antipsychotic medications for several months does not result in NAA changes... - Long-term treatment of rats with haloperidol: lack of an effect on brain N-acetyl aspartate levelsJuan Bustillo
Department of Psychiatry, University of New Mexico Health Sciences Center, Albuquerque, NM 87131 0001, USA
Neuropsychopharmacology 31:751-6. 2006..The documented lower NAA in chronically treated schizophrenia patients is most likely not a simple effect of antipsychotic medications... - The psychosocial treatment of schizophrenia: an updateJ Bustillo
Department of Psychiatry, University of New Mexico School of Medicine, Albuquerque, NM 87131, USA
Am J Psychiatry 158:163-75. 2001..The authors sought to update the randomized controlled trial literature of psychosocial treatments for schizophrenia... - Treatment of weight gain with fluoxetine in olanzapine-treated schizophrenic outpatientsJuan R Bustillo
Department of Psychiatry, Research Division, 2400 Tucker NE, University of New Mexico, Albuquerque, NM 87131, USA
Neuropsychopharmacology 28:527-9. 2003..Serotonin reuptake inhibitors are probably not a practical option to counteract weight gain induced by atypical antipsychotics. Atypical-induced weight gain may result from mechanisms other than 5HT reuptake blockade... - Effects of chronic haloperidol and clozapine treatments on frontal and caudate neurochemistry in schizophreniaJ R Bustillo
Department of Psychiatry, Research Division, University of New Mexico, 2400 Tucker NE, Albuquerque, NM 87131, USA
Psychiatry Res 107:135-49. 2001..Exposure to haloperidol-like drugs may in part account for the frontal NAA reductions previously reported in schizophrenia. Adjustment for proportion of voxel CSF should be considered in 1H-MRS studies... - Integrated treatment of schizophreniaRoshel Lenroot
Department of Psychiatry, School of Medicine, University of New Mexico, 2400 Tucker NE, Albuquerque, NM 87131, USA
Psychiatr Serv 54:1499-507. 2003..Emphasis is placed on areas of interaction, including patient adherence and the effect of antipsychotic medications on cognitive functioning. Recommendations are presented for specific clinical situations... - Maximizing the synergy between pharmacotherapy and psychosocial therapies for schizophreniaJohn Lauriello
Department of Psychiatry, University of New Mexico, 2400 Tucker Avenue NE, Albuquerque, NM 87131, USA
Psychiatr Clin North Am 26:191-211. 2003.... - Longitudinal follow-up of neurochemical changes during the first year of antipsychotic treatment in schizophrenia patients with minimal previous medication exposureJuan R Bustillo
Department of Psychiatry, Research Division, University of New Mexico, 2400 Tucker NE, Albuquerque, NM 87131, USA
Schizophr Res 58:313-21. 2002..The well-described reduced frontal NAA in schizophrenia may not be a trait of the illness but may represent medication effect or progression of the disease... - Antipsychotic dose and diminished neural modulation: a multi-site fMRI studyC Abbott
Dept of Psychiatry, University of New Mexico, Albuquerque, New Mexico 87131, United States
Prog Neuropsychopharmacol Biol Psychiatry 35:473-82. 2011..The purpose of the present investigation is to examine the effect of antipsychotic medication on independent neural networks during a motor task in a large, multi-site functional magnetic resonance imaging investigation... - Effects of ketamine on anterior cingulate glutamate metabolism in healthy humans: a 4-T proton MRS studyLaura M Rowland
Department of Psychiatry, MIND Imaging Center, University of New Mexico, USA
Am J Psychiatry 162:394-6. 2005..The authors' goal was to test in humans the hypothesis that N-methyl-d-aspartate receptor (NMDAR) antagonism results in increased cortical glutamate activity, as proposed by the NMDAR hypofunction model of schizophrenia... - Selective cognitive impairments associated with NMDA receptor blockade in humansLaura M Rowland
Maryland Psychiatric Research Center, University of Maryland School of Medicine, Baltimore, MD 21228, USA
Neuropsychopharmacology 30:633-9. 2005..Impaired cognition is a core feature of schizophrenia. A better understanding of NMDA antagonism, its physiological and cognitive consequences, may provide improved models of psychosis and cognitive therapeutics...
Research Grants
- Brain Glutamate and Outcome in SchizophreniaJuan R Bustillo; Fiscal Year: 2010..This is an essential step towards being able to select groups of patients whom may benefit from drugs that modulate glutamate function. ..