W Busse

Summary

Affiliation: University of Wisconsin
Country: USA

Publications

  1. pmc Safety and tolerability of the novel inhaled corticosteroid fluticasone furoate in combination with the β2 agonist vilanterol administered once daily for 52 weeks in patients >=12 years old with asthma: a randomised trial
    William W Busse
    Department of Medicine, University of Wisconsin, Madison, WI, USA
    Thorax 68:513-20. 2013
  2. doi request reprint Safety and efficacy of the prostaglandin D2 receptor antagonist AMG 853 in asthmatic patients
    William W Busse
    Department of Medicine, University of Wisconsin, Madison, Wis, USA
    J Allergy Clin Immunol 131:339-45. 2013
  3. doi request reprint The brain and asthma: what are the linkages?
    William W Busse
    Division of Allergy, Pulmonary and Critical Care, Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI 53792, USA
    Chem Immunol Allergy 98:14-31. 2012
  4. pmc Fluticasone furoate: once-daily evening treatment versus twice-daily treatment in moderate asthma
    Ashley Woodcock
    School of Translational Medicine, University of Manchester, Manchester, UK
    Respir Res 12:160. 2011
  5. doi request reprint Omalizumab and the risk of malignancy: results from a pooled analysis
    William Busse
    Department of Medicine, University of Wisconsin Medical School, Madison, WI, USA
    J Allergy Clin Immunol 129:983-9.e6. 2012
  6. doi request reprint Allergen immunotherapy in allergic respiratory diseases: from mechanisms to meta-analyses
    Ravi K Viswanathan
    Division of Allergy, Pulmonary, and Critical Care, Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI 53792, USA
    Chest 141:1303-14. 2012
  7. pmc Efficacy in asthma of once-daily treatment with fluticasone furoate: a randomized, placebo-controlled trial
    Ashley Woodcock
    School of Translational Medicine, Manchester Academic Health Science Centre, University of Manchester, UK
    Respir Res 12:132. 2011
  8. pmc Attitudes and actions of asthma patients on regular maintenance therapy: the INSPIRE study
    Martyn R Partridge
    Department of Respiratory Medicine, Faculty of Medicine, Imperial College London, London, UK
    BMC Pulm Med 6:13. 2006
  9. pmc The Urban Environment and Childhood Asthma (URECA) birth cohort study: design, methods, and study population
    James E Gern
    University of Wisconsin School of Medicine and Public Health, Madison, WI, USA
    BMC Pulm Med 9:17. 2009
  10. pmc The National Institutes of Allergy and Infectious Diseases networks on asthma in inner-city children: an approach to improved care
    William W Busse
    Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, Wis 53792, USA
    J Allergy Clin Immunol 125:529-37; quiz 538-9. 2010

Research Grants

  1. Severe Asthma From Respiratory Infections
    William W Busse; Fiscal Year: 2010
  2. Severe Asthma From Respiratory Infections
    William Busse; Fiscal Year: 2005
  3. MECHANISMS OF RHINOVIRUS INDUCED ASTHMA
    William Busse; Fiscal Year: 2002
  4. Severe Asthma From Respiratory Infections
    William Busse; Fiscal Year: 2009

Detail Information

Publications98

  1. pmc Safety and tolerability of the novel inhaled corticosteroid fluticasone furoate in combination with the β2 agonist vilanterol administered once daily for 52 weeks in patients >=12 years old with asthma: a randomised trial
    William W Busse
    Department of Medicine, University of Wisconsin, Madison, WI, USA
    Thorax 68:513-20. 2013
    ..The inhaled corticosteroid fluticasone furoate (FF) in combination with the long-acting β2 agonist vilanterol (VI) is in development for asthma and chronic obstructive pulmonary disease...
  2. doi request reprint Safety and efficacy of the prostaglandin D2 receptor antagonist AMG 853 in asthmatic patients
    William W Busse
    Department of Medicine, University of Wisconsin, Madison, Wis, USA
    J Allergy Clin Immunol 131:339-45. 2013
    ..AMG 853 is a potent, selective, orally bioavailable, small-molecule dual antagonist of human D-prostanoid and CRTH2...
  3. doi request reprint The brain and asthma: what are the linkages?
    William W Busse
    Division of Allergy, Pulmonary and Critical Care, Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI 53792, USA
    Chem Immunol Allergy 98:14-31. 2012
    ..Collectively, these data suggest that chronic stress enhances asthma severity through a number of novel mechanisms and the resulting increase in severity of asthma may not be responsiveness to standardly used treatments...
  4. pmc Fluticasone furoate: once-daily evening treatment versus twice-daily treatment in moderate asthma
    Ashley Woodcock
    School of Translational Medicine, University of Manchester, Manchester, UK
    Respir Res 12:160. 2011
    ..The objectives of this study were to compare the efficacy and safety of once-daily (OD) evening and twice-daily (BD) regimens of the novel inhaled corticosteroid fluticasone furoate (FF) in asthma patients...
  5. doi request reprint Omalizumab and the risk of malignancy: results from a pooled analysis
    William Busse
    Department of Medicine, University of Wisconsin Medical School, Madison, WI, USA
    J Allergy Clin Immunol 129:983-9.e6. 2012
    ..5%) compared with control subjects (0.2%). The previous analysis was based on limited available data, warranting further investigation...
  6. doi request reprint Allergen immunotherapy in allergic respiratory diseases: from mechanisms to meta-analyses
    Ravi K Viswanathan
    Division of Allergy, Pulmonary, and Critical Care, Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI 53792, USA
    Chest 141:1303-14. 2012
    ..Given the significant burden these allergic diseases impose on the health-care system, SIT appears to be a cost-effective adjunctive treatment in modifying the existing disease state...
  7. pmc Efficacy in asthma of once-daily treatment with fluticasone furoate: a randomized, placebo-controlled trial
    Ashley Woodcock
    School of Translational Medicine, Manchester Academic Health Science Centre, University of Manchester, UK
    Respir Res 12:132. 2011
    ....
  8. pmc Attitudes and actions of asthma patients on regular maintenance therapy: the INSPIRE study
    Martyn R Partridge
    Department of Respiratory Medicine, Faculty of Medicine, Imperial College London, London, UK
    BMC Pulm Med 6:13. 2006
    ....
  9. pmc The Urban Environment and Childhood Asthma (URECA) birth cohort study: design, methods, and study population
    James E Gern
    University of Wisconsin School of Medicine and Public Health, Madison, WI, USA
    BMC Pulm Med 9:17. 2009
    ..This paper describes the study design, methods, and population of the Urban Environment and Childhood Asthma (URECA) study, which was established to investigate the immunologic causes of asthma among inner-city children...
  10. pmc The National Institutes of Allergy and Infectious Diseases networks on asthma in inner-city children: an approach to improved care
    William W Busse
    Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, Wis 53792, USA
    J Allergy Clin Immunol 125:529-37; quiz 538-9. 2010
    ....
  11. doi request reprint A review of treatment with mepolizumab, an anti-IL-5 mAb, in hypereosinophilic syndromes and asthma
    William W Busse
    Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, Wis, USA
    J Allergy Clin Immunol 125:803-13. 2010
    ..Mepolizumab reduced airway and blood eosinophils and prevented asthma exacerbations. Thus, mepolizumab may be effective for long-term treatment of patients with selected eosinophilic disorders...
  12. ncbi request reprint Determinants of risk factors for asthma
    W W Busse
    University of Wisconsin Madison Medical School, Madison 53792 2454, USA
    Can Respir J 6:97-101. 1999
    ....
  13. doi request reprint Daclizumab improves asthma control in patients with moderate to severe persistent asthma: a randomized, controlled trial
    William W Busse
    Department of Medicine, Section of Allergy, Pulmonary, and Critical Care Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI 53792, USA
    Am J Respir Crit Care Med 178:1002-8. 2008
    ..The mechanism of action likely involves inhibition of proinflammatory cytokine generation by IL-2R blockade in activated T cells. Clinical trial registered with www.clinicaltrials.gov (NCT00028288)...
  14. doi request reprint Comparison of adjustable- and fixed-dose budesonide/formoterol pressurized metered-dose inhaler and fixed-dose fluticasone propionate/salmeterol dry powder inhaler in asthma patients
    William W Busse
    University of Wisconsin Hospitals and Clinics, Madison, Wis 53792, USA
    J Allergy Clin Immunol 121:1407-14, 1414.e1-6. 2008
    ..The adjustable-dose budesonide/formoterol dry powder inhaler (DPI) has demonstrated similar or greater asthma control with less inhaled corticosteroid compared with the fixed-dose budesonide/formoterol DPI...
  15. doi request reprint The Inhaled Steroid Treatment As Regular Therapy in Early Asthma (START) study 5-year follow-up: effectiveness of early intervention with budesonide in mild persistent asthma
    William W Busse
    Department of Medicine, University of Wisconsin School of Medicine and Public Health, J5 219 CSC, Box 2454, 600 Highland Ave, Madison, WI 53792, USA
    J Allergy Clin Immunol 121:1167-74. 2008
    ....
  16. ncbi request reprint Addressing issues of asthma in inner-city children
    William W Busse
    University of Wisconsin School of Medicine and Public Health, Madison, WI 53792, USA
    J Allergy Clin Immunol 119:43-9. 2007
    ....
  17. pmc Asthma exacerbations. 2: aetiology
    A M Singh
    Department of Medicine, Section of Allergy, Pulmonary and Critical Care Medicine, University of Wisconsin Medical School, Madison, Wisconsin, USA
    Thorax 61:809-16. 2006
    ..Through an understanding of underlying causes of asthma exacerbations, treatments with increased effectiveness may be developed, and it is these future developments that may directly influence the morbidity and mortality of the disease...
  18. ncbi request reprint Efficacy of montelukast during the allergy season in patients with chronic asthma and seasonal aeroallergen sensitivity
    William W Busse
    Department of Medicine, University of Wisconsin Medical School, Madison, Wisconsin 53792, USA
    Ann Allergy Asthma Immunol 96:60-8. 2006
    ..Montelukast has proven efficacy in the treatment of chronic asthma and seasonal allergic rhinitis, but it has not been evaluated in the subpopulation of asthmatic patients with seasonal asthma symptoms...
  19. pmc Role of viral respiratory infections in asthma and asthma exacerbations
    William W Busse
    Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA
    Lancet 376:826-34. 2010
    ....
  20. pmc Vaccination of patients with mild and severe asthma with a 2009 pandemic H1N1 influenza virus vaccine
    William W Busse
    University of Wisconsin School of Medicine and Public Health, Madison, Wis, USA
    J Allergy Clin Immunol 127:130-7, 137.e1-3. 2011
    ..Asthma was the most common comorbidity of patients hospitalized with 2009 H1N1 influenza...
  21. ncbi request reprint Anti-immunoglobulin E (omalizumab) therapy in allergic asthma
    W W Busse
    Department of Medicine, Allergy and Immunology Section, University of Wisconsin Medical School, Madison, Wisconsin, USA
    Am J Respir Crit Care Med 164:S12-7. 2001
    ..In addition, anti-IgE (omalizumab) has been shown to be safe and well tolerated...
  22. ncbi request reprint Fluticasone propionate compared with zafirlukast in controlling persistent asthma: a randomized double-blind, placebo-controlled trial
    W Busse
    University of Wisconsin Hospital and Clinics, H6 367 Clinical Science Center, 600 Highland Avenue, Madison, WI 53792 2454, USA
    J Fam Pract 50:595-602. 2001
    ..The objective of our study was to compare the efficacy and safety of fluticasone propionate (an inhaled corticosteroid) with zafirlukast (a leukotriene modifier) for persistent asthma...
  23. pmc The relationship of airway hyperresponsiveness and airway inflammation: Airway hyperresponsiveness in asthma: its measurement and clinical significance
    William W Busse
    Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI 53792, USA
    Chest 138:4S-10S. 2010
    ..Insight into how these interrelated components of AHR can contribute to asthma is gained by studying treatment effects and models of asthma provocation...
  24. doi request reprint Asthma diagnosis and treatment: filling in the information gaps
    William W Busse
    Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI 53792, USA
    J Allergy Clin Immunol 128:740-50. 2011
    ..A major morbidity in asthmatic patients occurs with exacerbations and in patients with severe disease. Novel approaches to treatment for these conditions will be an important advance to reduce the morbidity associated with asthma...
  25. doi request reprint Fluticasone furoate demonstrates efficacy in patients with asthma symptomatic on medium doses of inhaled corticosteroid therapy: an 8-week, randomised, placebo-controlled trial
    William W Busse
    Department of Medicine, University of Wisconsin, K4 910 CSC, 600 Highland Avenue, Madison, WI 53792, USA
    Thorax 67:35-41. 2012
    ..FF is being developed as a once-daily treatment in combination with the long-acting β(2) agonist vilanterol trifenatate for asthma and chronic obstructive pulmonary disease...
  26. pmc Randomized trial of omalizumab (anti-IgE) for asthma in inner-city children
    William W Busse
    Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI 53719, USA
    N Engl J Med 364:1005-15. 2011
    ..It has also revealed the limitations of environmental remediation and guidelines-based therapy in achieving greater disease control...
  27. ncbi request reprint Cysteinyl leukotrienes in allergic inflammation: strategic target for therapy
    William Busse
    University of Wisconsin, Madison Medical School, Department of Medicine, 15 220 Clinical Science Center, 600 Highland Ave, Madison, WI 53792 2454, USA
    Chest 127:1312-26. 2005
    ..The mechanism of action of LTRAs leads to their effects on systemic allergic inflammatory processes...
  28. ncbi request reprint Anti-immunoglobulin E for the treatment of allergic disease
    W Busse
    Department of Medicine, Allergy and Clinical Immunology Section, University of Wisconsin, Madison, Wisconsin 53792, USA
    Curr Opin Allergy Clin Immunol 1:105-8. 2001
    ..The following information will review recent experiences with anti-IgE and discuss the conditions in which this approach may be effective...
  29. ncbi request reprint School examinations enhance airway inflammation to antigen challenge
    Lin Ying Liu
    Allergy and Immunology and Pulmonary and Critical Care Sections of the Department of Medicine, University of Wisconsin, Madison, Wisconsin, USA
    Am J Respir Crit Care Med 165:1062-7. 2002
    ..Our findings suggest that stress associated with final examinations can act as a cofactor to increase eosinophilic airway inflammation to antigen challenge and thus may enhance asthma severity...
  30. ncbi request reprint Interferon-gamma enhances rhinovirus-induced RANTES secretion by airway epithelial cells
    Shinichi Konno
    Department of Medicine, University of Wisconsin Madison, Madison, Wisconsin, USA
    Am J Respir Cell Mol Biol 26:594-601. 2002
    ..These findings suggest that IFN-gamma, by upregulating RANTES secretion, could be an important regulator of the initial immune response to rhinovirus infections...
  31. ncbi request reprint Mechanisms of asthma
    William W Busse
    Allergy and Clinical Immunology, University of Wisconsin Department of Medicine, Madison, WI, USA
    J Allergy Clin Immunol 111:S799-804. 2003
    ..The contribution of genetics to asthma has been examined in a wide variety of studies, ranging from epidemiologic association and twin studies all the way to molecular analysis through microarray gene expression experiments...
  32. ncbi request reprint Enhanced generation of helper T type 1 and 2 chemokines in allergen-induced asthma
    Linying Liu
    Allergy and Immunology Section, and Pulmonary and Critical Care Section, Department of Medicine, University of Wisconsin, Madison, Wisconsin 53792 9988, USA
    Am J Respir Crit Care Med 169:1118-24. 2004
    ..However, asthma subjects with a dual-responder phenotype have greater generation of chemokines that may lead to enhanced airway inflammation and obstruction after allergen exposure...
  33. ncbi request reprint Effects of inflammatory cytokines on the permeability of human lung microvascular endothelial cell monolayers and differential eosinophil transmigration
    Julie B Sedgwick
    Division of Allergy and Immunology, Department of Medicine, University of Wisconsin, Madison, USA
    J Allergy Clin Immunol 110:752-6. 2002
    ..Some of these mediators might also affect the permeability of underlying vascular endothelium...
  34. ncbi request reprint Decreased expression of membrane IL-5 receptor alpha on human eosinophils: I. Loss of membrane IL-5 receptor alpha on airway eosinophils and increased soluble IL-5 receptor alpha in the airway after allergen challenge
    Lin Ying Liu
    Allergy and Immunology, Department of Medicine, University of Wisconsin, Madison 53792, USA
    J Immunol 169:6452-8. 2002
    ..These observations provide a potential explanation for the inability of anti-IL-5 therapy to suppress airway hyperresponsiveness to inhaled Ag, despite a reduction in eosinophil recruitment...
  35. doi request reprint Comparative effect of body mass index on response to asthma controller therapy
    E Rand Sutherland
    Department of Medicine, National Jewish Health, Denver, Colorado, USA
    Allergy Asthma Proc 31:20-5. 2010
    ..05). FP produced a significantly greater clinical response for normal, overweight, and obese subjects compared with montelukast. Irrespective of BMI, FP appears to be the more effective asthma controller therapy...
  36. pmc The presence of rhinovirus in lower airways of patients with bronchial asthma
    Monika Wos
    University of Wisconsin, 600 Highland Avenue, Madison, WI 53792, USA
    Am J Respir Crit Care Med 177:1082-9. 2008
    ..The common cold virus, human rhinovirus (HRV), is the most frequent cause of asthma exacerbations. However, a possible contribution of HRV to the pathogenesis of chronic, persistent asthma has not been defined...
  37. doi request reprint A randomized, double-blind, placebo-controlled study of tumor necrosis factor-alpha blockade in severe persistent asthma
    Sally E Wenzel
    Division of Pulmonary, Allergy, and Critical Care Medicine, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA
    Am J Respir Crit Care Med 179:549-58. 2009
    ..The treatment effect of golimumab, a human monoclonal antibody against tumor necrosis factor (TNF)-alpha, in severe persistent asthma is unknown...
  38. ncbi request reprint Effect of omalizumab on the need for rescue systemic corticosteroid treatment in patients with moderate-to-severe persistent IgE-mediated allergic asthma: a pooled analysis
    William W Busse
    University of Wisconsin, Madison, WI, USA
    Curr Med Res Opin 23:2379-86. 2007
    ..We investigated the effect of omalizumab on asthma outcomes in a retrospective pooled analysis of data from phase III clinical trials in patients (>or= 12 years) with moderate-to-severe persistent IgE-mediated allergic asthma...
  39. ncbi request reprint A comparison of the airway response to segmental antigen bronchoprovocation in atopic asthma and allergic rhinitis
    Elizabeth A Becky Kelly
    Pulmonary and Critical Care Section of the Department of Medicine, University of Wisconsin, Madison 53792, USA
    J Allergy Clin Immunol 111:79-86. 2003
    ..Patients with allergic asthma and those with allergic rhinitis (without asthma) share many immunopathologic features but differ in the presence of lower airway symptoms in response to antigen...
  40. ncbi request reprint Ligation of intercellular adhesion molecule 3 inhibits GM-CSF production by human eosinophils
    Julie M Kessel
    Departments of Pediatrics and Medicine, University of Wisconsin Medical School, Madison, WI 53792 4108, USA
    J Allergy Clin Immunol 111:1024-31. 2003
    ..Intercellular adhesion molecule 3 (ICAM-3) has recently been identified on the surface of eosinophils...
  41. doi request reprint Host immune responses to rhinovirus: mechanisms in asthma
    John T Kelly
    Section of Allergy, Pulmonary and Critical Care Medicine, Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI 53792, USA
    J Allergy Clin Immunol 122:671-82; quiz 683-4. 2008
    ..Therefore, understanding the immune response to rhinovirus is a key step in defining mechanisms of asthma, exacerbations, and, perhaps most importantly, improved treatment...
  42. ncbi request reprint Comparison of the effects of repetitive low-dose and single-dose antigen challenge on airway inflammation
    Lin Ying Liu
    Allergy and Immunology Section of the Department of Medicine, University of Wisconsin Hospital, Madison, USA
    J Allergy Clin Immunol 111:818-25. 2003
    ..Allergen provocation is usually administered as a relatively large single-dose challenge that might not reflect a chronic, natural, low-dose airborne allergen exposure...
  43. pmc Neural circuitry underlying the interaction between emotion and asthma symptom exacerbation
    Melissa A Rosenkranz
    Department of Psychology, Laboratory for Affective Neuroscience, University of Wisconsin, 1202 West Johnson Street, Madison, WI 53706, USA
    Proc Natl Acad Sci U S A 102:13319-24. 2005
    ....
  44. ncbi request reprint Expression of interleukin-5- and granulocyte macrophage-colony-stimulating factor-responsive genes in blood and airway eosinophils
    Mary E Bates
    Department of Biomolecular Chemistry, University of Wisconsin, 1300 University Ave, Madison, WI 53706, USA
    Am J Respir Cell Mol Biol 30:736-43. 2004
    ..e., lymphotoxin beta and CD24). These studies have identified several transcriptional targets of IL-5 and GM-CSF in human eosinophils and suggest that a number of protein products are critical to the responsiveness of airway eosinophils...
  45. ncbi request reprint Omalizumab, anti-IgE recombinant humanized monoclonal antibody, for the treatment of severe allergic asthma
    W Busse
    Department of Medicine, University of Wisconsin Hospital and Clinics, University of Wisconsin, Madison, 53792, USA
    J Allergy Clin Immunol 108:184-90. 2001
    ..CONCLUSION: The addition of omalizumab to standard asthma therapy reduces asthma exacerbations and decreases inhaled corticosteroid and rescue medication use...
  46. pmc Asthma: clinical expression and molecular mechanisms
    Robert F Lemanske
    Department of Pediatrics, University of Wisconsin Medical School, Madison, Wis, USA
    J Allergy Clin Immunol 125:S95-102. 2010
    ..This review will highlight some of the important clinical features of asthma and emphasize recent advances in both pathophysiology and treatment...
  47. pmc Age-related changes in eosinophil function in human subjects
    Sameer K Mathur
    Section of Allergy, Pulmonary and Critical Care, Department of Medicine, University of Wisconsin School of Medicine and Public Health, K4 910 Clinical Sciences Center, 600 Highland Ave, Madison, WI 53792, USA
    Chest 133:412-9. 2008
    ..We sought to define age-related changes in eosinophil function and their potential implications for asthma...
  48. pmc Evaluation of structure-function relationships in asthma using multidetector CT and hyperpolarized He-3 MRI
    Sean B Fain
    Department of Medical Physics, University of Wisconsin, Madison, WI 53792, USA
    Acad Radiol 15:753-62. 2008
    ....
  49. pmc Up-regulation and activation of eosinophil integrins in blood and airway after segmental lung antigen challenge
    Mats W Johansson
    Department of Biomolecular Chemistry, University of Wisconsin, Madison, WI53706, USA
    J Immunol 180:7622-35. 2008
    ..Finally, eosinophils present in IL-5-rich airway fluid have a hyperadhesive phenotype associated with increased surface expression of alpha(M)beta(2) and activation of beta(2) integrins...
  50. ncbi request reprint Rhinovirus-induced interferon-gamma and airway responsiveness in asthma
    G Daniel Brooks
    Departments of Medicine and Pediatrics, University of Wisconsin, Madison, Wisconsin, USA
    Am J Respir Crit Care Med 168:1091-4. 2003
    ....
  51. pmc Attenuated P2X7 pore function as a risk factor for virus-induced loss of asthma control
    Loren C Denlinger
    Section of Allergy, Pulmonary, and Critical Care, Department of Medicine, University of Wisconsin School of Medicine and Public Health, 600 Highland Avenue, P O Box 9988, Madison, WI 53792, USA
    Am J Respir Crit Care Med 179:265-70. 2009
    ..Upper respiratory tract infection is a guideline accepted risk domain for the loss of asthma control. The ionotrophic nucleotide receptor P2X(7) regulates compartmentalized acute inflammation and the immune response to airway pathogens...
  52. ncbi request reprint Oxidized low-density lipoprotein activates migration and degranulation of human granulocytes
    Julie B Sedgwick
    University of Wisconsin, H6 355 CSC 3244 600 Highland Ave, Madison, WI 53792, USA
    Am J Respir Cell Mol Biol 29:702-9. 2003
    ..05). Therefore, in vivo influx and oxidation of LDL may be an important mediator for the initiation of bronchial inflammation where granulocytes are recruited to the lung...
  53. doi request reprint Short-term safety of somatropin inhalation powder in adults with mild to moderate asthma
    Harold S Nelson
    Department of Medicine, National Jewish Health, Denver, Colorado 80206, USA
    Allergy Asthma Proc 30:325-32. 2009
    ..Future studies of SIP may enroll subjects with mild to moderate asthma for longer-term evaluation of safety and efficacy...
  54. pmc Similar colds in subjects with allergic asthma and nonatopic subjects after inoculation with rhinovirus-16
    Jennifer P DeMore
    Department of Medicine, University of Wisconsin Madison, Madison, Wis, USA
    J Allergy Clin Immunol 124:245-52, 252.e1-3. 2009
    ..Rhinovirus infections are frequent causes of asthma exacerbations...
  55. ncbi request reprint Serum and low-density lipoprotein enhance interleukin-8 secretion by airway epithelial cells
    James E Gern
    Department of Pediatrics, University of Wisconsin Madison, Madison, WI 53792 9988, USA
    Am J Respir Cell Mol Biol 29:483-9. 2003
    ..This effect may represent an innate mechanism for the recruitment of neutrophils to the airway in response to noxious stimuli, such as viral infections, that increase vascular permeability...
  56. doi request reprint Safety profile, pharmacokinetics, and biologic activity of MEDI-563, an anti-IL-5 receptor alpha antibody, in a phase I study of subjects with mild asthma
    William W Busse
    University of Wisconsin School of Medicine and Public Health, Madison, Wis, USA
    J Allergy Clin Immunol 125:1237-1244.e2. 2010
    ..IL-5 is responsible for eosinophil differentiation, proliferation, and activation; IL-5 receptors are expressed on eosinophils and their progenitors, and targeting such receptors induces eosinophil apoptosis...
  57. ncbi request reprint Double-stranded RNA induces the synthesis of specific chemokines by bronchial epithelial cells
    James E Gern
    Department of Pediatrics, University of Wisconsin Madison Medical School, Madison, Wisconsin, USA
    Am J Respir Cell Mol Biol 28:731-7. 2003
    ..Moreover, these data suggest that this may be an important mechanism for the selective secretion of chemokines by viruses (e.g., rhinovirus, respiratory syncytial virus, influenza) that synthesize dsRNA during replication...
  58. ncbi request reprint Similar frequency of rhinovirus-infectible cells in upper and lower airway epithelium
    Anne G Mosser
    Department of Medicine, Division of Allergy and Immunology, University of Wisconsin, Madison, Wisconsin 53792, USA
    J Infect Dis 185:734-43. 2002
    ..In confirming that RV can infect cells in the lower airway, these results suggest that lower airway dysfunction occurs through this mechanism in susceptible persons...
  59. ncbi request reprint Relationship of viral infections to wheezing illnesses and asthma
    James E Gern
    Department of Pediatrics, University of Wisconsin Hospital, 600 Highland Avenue, Madison, Wisconsin 53792, USA
    Nat Rev Immunol 2:132-8. 2002
    ..This article discusses the influence of viral infections on mechanisms of virus-induced airway inflammation in relationship to the development, persistence and severity of asthma...
  60. ncbi request reprint Lung function in adults with stable but severe asthma: air trapping and incomplete reversal of obstruction with bronchodilation
    Ronald L Sorkness
    Univ of Wisconsin, 777 Highland Ave, Madison, WI 53705, USA
    J Appl Physiol (1985) 104:394-403. 2008
    ..We conclude that air trapping is a characteristic feature of the severe asthma population, suggesting that there is a pathological process associated with severe asthma that makes airways more vulnerable to this component...
  61. ncbi request reprint Ligation of intercellular adhesion molecule 3 induces apoptosis of human blood eosinophils and neutrophils
    Julie M Kessel
    Department of Pediatrics, University of Wisconsin School of Medicine and Public Health, WI 53715, USA
    J Allergy Clin Immunol 118:831-6. 2006
    ..Intercellular adhesion molecule 3 (ICAM-3) is highly expressed on human granulocytes, including eosinophils and neutrophils, but the functions of ICAM-3 in these cells are not well understood...
  62. ncbi request reprint Peripheral blood eosinophils from patients with allergic asthma contain increased intracellular eosinophil-derived neurotoxin
    Julie B Sedgwick
    Allergy and Immunology, Department of Medicine, University of Wisconsin, Madison, WI 53792, USA
    J Allergy Clin Immunol 114:568-74. 2004
    ....
  63. ncbi request reprint 6. Asthma: Factors underlying inception, exacerbation, and disease progression
    Robert F Lemanske
    Departments of Pediatrics and Medicine, University Hospital, University of Wisconsin Medical School, 600 Highland Avenue K4 916, Madison, WI 43792, USA
    J Allergy Clin Immunol 117:S456-61. 2006
    ..Unfortunately, despite the availability of effective therapies, suboptimal asthma control exists in many patients on a worldwide basis. The future development of novel therapies and treatment paradigms should address these disparities...
  64. ncbi request reprint Quantitative and qualitative analysis of rhinovirus infection in bronchial tissues
    Anne G Mosser
    University of Wisconsin, K4 928 CSC 9988, 600 Highland Avenue, Madison, WI 53792, USA
    Am J Respir Crit Care Med 171:645-51. 2005
    ..These results confirm that infection of lower airway tissues is a frequent finding during a cold and further demonstrate a patchy distribution of infected cells, a pattern similar to that reported in upper airway tissues...
  65. ncbi request reprint Effects of the very late adhesion molecule 4 antagonist WAY103 on human peripheral blood eosinophil vascular cell adhesion molecule 1-dependent functions
    Julie B Sedgwick
    Allergy and Immunology Unit, Department of Medicine, University of Wisconsin, Madison, WI, USA
    J Allergy Clin Immunol 116:812-9. 2005
    ..Small-molecule VLA-4 antagonists have been proposed as a therapeutic mechanism to prevent eosinophil infiltration in asthma; however, they might affect other eosinophil functions...
  66. ncbi request reprint The role of rhinovirus in asthma exacerbations
    Samuel L Friedlander
    Division of Allergy and Immunology, Department of Medicine, University of Wisconsin, Madison, WI 53792, USA
    J Allergy Clin Immunol 116:267-73. 2005
    ..Advances in our understanding of this interaction might provide knowledge that could ultimately lead to specific treatment modalities to prevent and/or treat this significant burden of asthma exacerbations...
  67. ncbi request reprint Generation of Th1 and Th2 chemokines by human eosinophils: evidence for a critical role of TNF-alpha
    Lin Ying Liu
    Section of Allergy, Pulmonary, and Critical Care Medicine, Department of Medicine, University of Wisconsin School of Medicine, Madison, WI 53792, USA
    J Immunol 179:4840-8. 2007
    ....
  68. ncbi request reprint Decreased expression of membrane IL-5 receptor alpha on human eosinophils: II. IL-5 down-modulates its receptor via a proteinase-mediated process
    Lin Ying Liu
    Allergy and Immunology, Department of Medicine, University of Wisconsin, Madison 53792, USA
    J Immunol 169:6459-66. 2002
    ..These findings suggest that IL-5-activated eosinophils may lose mIL-5Ralpha and release sIL-5Ralpha in vivo, which may limit IL-5-dependent inflammatory events in diseases such as asthma...
  69. ncbi request reprint Advances in mechanisms of allergy
    Bruce S Bochner
    Department of Medicine, Division of Allergy and Clinical Immunology, Johns Hopkins University School of Medicine, Asthma and Allergy Center, 5501 Hopkins Bayview Circle, Room 2B 71, Baltimore, MD 21224 6801, USA
    J Allergy Clin Immunol 113:868-75. 2004
    ..When appropriate, articles from other journals have been included to supplement the topics being presented...
  70. ncbi request reprint Chemokine receptor expression on human eosinophils from peripheral blood and bronchoalveolar lavage fluid after segmental antigen challenge
    Lin Ying Liu
    Allergy and Immunology Section, Department of Medicine, University of Wisconsin, Madison, WI 53972, USA
    J Allergy Clin Immunol 112:556-62. 2003
    ..Chemokine receptors likely play a role in this complex process. However, reports of chemokine receptor expression on human eosinophils are conflicting...
  71. ncbi request reprint 6. Asthma
    Robert F Lemanske
    Departments of Medicine and Pediatrics, University of Wisconsin Medical School, Madison, WI 53792, USA
    J Allergy Clin Immunol 111:S502-19. 2003
    ....
  72. pmc Three-dimensional imaging of ventilation dynamics in asthmatics using multiecho projection acquisition with constrained reconstruction
    James H Holmes
    Department of Medical Physics, University of Wisconsin Madison, Madison, Wisconsin, USA
    Magn Reson Med 62:1543-56. 2009
    ..While multidetector CT can provide information about static regional air trapping, it is unable to depict dynamics in a setting more comparable to a spirometry maneuver and explore the longitudinal time evolution of the trapped regions...
  73. ncbi request reprint Asthma: diagnosis and management
    Sameer K Mathur
    Section of Allergy, Pulmonary, and Critical Care, Department of Medicine, University of Wisconsin Medical School, Madison, WI 53792, USA
    Med Clin North Am 90:39-60. 2006
    ....
  74. ncbi request reprint Human rhinovirus models in asthma
    Anne Marie Singh
    Department of Medicine, University of Wisconsin Medical School, Madison, WI 53792, USA
    Contrib Microbiol 14:12-20. 2007
    ..Work further investigating the mechanisms of exacerbation caused by RV infection will ultimately lead to new modalities of treatment and possibly prevention of this common and significant cause of acute asthma...
  75. ncbi request reprint Asthma
    Saju S Eapen
    University of Wisconsin Medical School, Madison, Wisconsin, USA
    Clin Allergy Immunol 16:325-53. 2002
    ..Enhanced knowledge of molecular and cellular events in the inflammatory process would inevitably lead to newer, more specific, therapeutic agents, which would potentially be curative rather than palliative...
  76. ncbi request reprint Refractory asthma
    Maureen McGeehan
    Department of Medicine, University of Wisconsin, 600 Highland Avenue, Madison, WI 53792, USA
    Med Clin North Am 86:1073-90. 2002
    ..Unfortunately, most alternative approaches require more rigorous evidence to support their regular use...
  77. pmc Management of asthma based on exhaled nitric oxide in addition to guideline-based treatment for inner-city adolescents and young adults: a randomised controlled trial
    Stanley J Szefler
    National Jewish Health, Denver, CO, USA
    Lancet 372:1065-72. 2008
    ....
  78. ncbi request reprint Early intervention with budesonide in mild persistent asthma: a randomised, double-blind trial
    Romain A Pauwels
    Department of Respiratory Diseases, Ghent University Hospital, Ghent, Belgium
    Lancet 361:1071-6. 2003
    ..Although inhaled glucocorticosteroids are recommended for persistent asthma, their long-term effect on recent onset, mild, persistent asthma has yet to be established...
  79. pmc Correlation of systemic superoxide dismutase deficiency to airflow obstruction in asthma
    Suzy A A Comhair
    Department of Pathology, Cleveland Clinic Foundation, OH 44195, USA
    Am J Respir Crit Care Med 172:306-13. 2005
    ....
  80. ncbi request reprint Efficacy and safety of mometasone furoate administered once-daily in the evening in patients with persistent asthma dependent on inhaled corticosteroids
    Anthony D'Urzo
    Primary Care Lung Clinic, Toronto, Ontario, Canada
    Curr Med Res Opin 21:1281-9. 2005
    ..Since asthma is frequently worse at night, evening dosing appears to be a more obvious choice to accommodate the chronobiology of asthma than morning dosing...
  81. pmc Molecular phenotyping of severe asthma using pattern recognition of bronchoalveolar lavage-derived cytokines
    Allan R Brasier
    Department of Internal Medicine, University of Texas Medical Branch, Galveston, TX 77555 1060, USA
    J Allergy Clin Immunol 121:30-37.e6. 2008
    ..Asthma is a heterogeneous clinical disorder. Methods for objective identification of disease subtypes will focus on clinical interventions and help identify causative pathways. Few studies have explored phenotypes at a molecular level...
  82. ncbi request reprint Is interleukin-10 a "10" in virus-provoked asthma?
    William W Busse
    Am J Respir Crit Care Med 172:405-6. 2005
  83. pmc Investigative bronchoprovocation and bronchoscopy in airway diseases
    William W Busse
    University of Wisconsin Madison, USA
    Am J Respir Crit Care Med 172:807-16. 2005
    ..Since the last critical review more than a decade ago, some of the techniques and applications have changed, and untoward events have occurred, raising safety concerns and increasing institutional review scrutiny...
  84. ncbi request reprint Rate of response of individual asthma control measures varies and may overestimate asthma control: an analysis of the goal study
    Eric D Bateman
    University of Cape Town, Cape Town, South Africa
    J Asthma 44:667-73. 2007
    ....
  85. ncbi request reprint Severe asthma in adults: what are the important questions?
    Pascal Chanez
    INSERM U454 and Clinique des Maladies Respiratoires, Montpellier, France
    J Allergy Clin Immunol 119:1337-48. 2007
    ..Inhaled corticosteroids and bronchodilators are the mainstay of treatment, but patients with SRA remain uncontrolled, indicating a need for new therapies...
  86. ncbi request reprint Effects of early intervention with inhaled budesonide on lung function in newly diagnosed asthma
    Paul M O'Byrne
    Department of Medicine, McMaster University Medical Center, 1200 Main St West, Hamilton, ON, Canada
    Chest 129:1478-85. 2006
    ..Asthmatic patients lose lung function faster than normal subjects. The effectiveness of early intervention with inhaled corticosteroids on this decline in lung function is not established in recent-onset disease...
  87. ncbi request reprint Effects of mometasone furoate given once daily in the evening on lung function and symptom control in persistent asthma
    Jill P Karpel
    Albert Einstein College of Medicine, Beth Thalheim Asthma Center, North Shore Long Island Jewish Health System, New Hyde Park, NY 11040, USA
    Ann Pharmacother 39:1977-83. 2005
    ..The chronobiology of asthma suggests that, for once-daily dosing, an evening dose may be the most effective treatment paradigm...
  88. ncbi request reprint Who is captain of the inflammatory ship in asthma?
    Elizabeth A B Kelly
    Am J Respir Crit Care Med 169:551-2. 2004
  89. ncbi request reprint Effects of treatment with anti-immunoglobulin E antibody omalizumab on airway inflammation in allergic asthma
    Ratko Djukanovic
    Respiratory Cell and Molecular Biology, Division of Infection, Inflammation, and Repair, University of Southampton, Southampton, UK
    Am J Respir Crit Care Med 170:583-93. 2004
    ..The lack of effect of omalizumab on methacholine responsiveness suggests that IgE or eosinophils may not be causally linked to airway hyperresponsiveness to methacholine in mild to moderate asthma...
  90. ncbi request reprint Can guideline-defined asthma control be achieved? The Gaining Optimal Asthma ControL study
    Eric D Bateman
    UCT Lung Institute, P O Box 34560, Groote Schuur 7937, Cape Town, South Africa
    Am J Respir Crit Care Med 170:836-44. 2004
    ..07-0.27 per patient per year) and improvement in health status were significantly better with salmeterol/fluticasone. This study confirms that the goal of guideline-derived asthma control was achieved in a majority of the patients...
  91. pmc Airway lipoxin A4 generation and lipoxin A4 receptor expression are decreased in severe asthma
    Anna Planagumà
    Pulmonary and Critical Care Medicine Division, Department of Internal Medicine, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
    Am J Respir Crit Care Med 178:574-82. 2008
    ..Airway inflammation is common in severe asthma despite antiinflammatory therapy with corticosteroids. Lipoxin A(4) (LXA(4)) is an arachidonic acid-derived mediator that serves as an agonist for resolution of inflammation...
  92. ncbi request reprint Eosinophil beta 1 integrin activation state correlates with asthma activity in a blind study of inhaled corticosteroid withdrawal
    Mats W Johansson
    J Allergy Clin Immunol 117:1502-4. 2006
  93. ncbi request reprint Effectiveness of early budesonide intervention in Caucasian versus Asian patients with asthma: 3-year results of the START study
    Wan C Tan
    iCAPTURE Centre, UBC, St Paul s Hospital, Vancouver, and Department of Medicine, McMaster University, Hamilton, ON, Canada
    Respirology 11:767-75. 2006
    ..The present analysis compared the efficacy of early intervention with inhaled budesonide in Caucasian and Asian patients over the first 3 years of the inhaled Steroid Treatment As Regular Therapy in early asthma study...
  94. ncbi request reprint The relationship of rhinovirus-associated asthma hospitalizations with inhaled corticosteroids and smoking
    Daniel L Venarske
    Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37230 8300 USA
    J Infect Dis 193:1536-43. 2006
    ....
  95. ncbi request reprint Early intervention of recent onset mild persistent asthma in children aged under 11 yrs: the Steroid Treatment As Regular Therapy in early asthma (START) trial
    Yu Zhi Chen
    Department of Pediatrics, Capital Institute of Pediatrics, Beijing, China
    Pediatr Allergy Immunol 17:7-13. 2006
    ....
  96. ncbi request reprint Severe asthma: lessons from the Severe Asthma Research Program
    Sally E Wenzel
    University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    J Allergy Clin Immunol 119:14-21; quiz 22-3. 2007
    ..Future studies will specifically evaluate the role of inflammatory/oxidative processes, infection, genetics, and the distal lung in the pathogenesis of severe asthma...
  97. pmc Characterization of the severe asthma phenotype by the National Heart, Lung, and Blood Institute's Severe Asthma Research Program
    Wendy C Moore
    Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    J Allergy Clin Immunol 119:405-13. 2007
    ..Severe asthma causes the majority of asthma morbidity. Understanding mechanisms that contribute to the development of severe disease is important...
  98. ncbi request reprint Determinants of response to fluticasone propionate and salmeterol/fluticasone propionate combination in the Gaining Optimal Asthma controL study
    Søren E Pedersen
    Department of Pediatrics, University of Southern Denmark, Pediatric Research Unit, Kolding Hospital, Kolding, Denmark
    J Allergy Clin Immunol 120:1036-42. 2007
    ..Approximately two thirds of patients achieved well-controlled (WC) asthma, and one third continued to have asthma that was not well controlled (NWC)...

Research Grants16

  1. Severe Asthma From Respiratory Infections
    William W Busse; Fiscal Year: 2010
    ..These studies will provide new insights into the mechanisms of asthma, particularly severe disease, and possibilities of new approaches to treatment. ..
  2. Severe Asthma From Respiratory Infections
    William Busse; Fiscal Year: 2005
    ..It is proposed that these studies will provide new insights into mechanisms of asthma, and particularly severe persistent disease, and potential new approaches to treatment. ..
  3. MECHANISMS OF RHINOVIRUS INDUCED ASTHMA
    William Busse; Fiscal Year: 2002
    ..The proposed studies will provide new evidence as the mechanisms by which RV-infected epithelial cells cause granulocytic bronchial inflammation and asthma exacerbations. ..
  4. Severe Asthma From Respiratory Infections
    William Busse; Fiscal Year: 2009
    ..These studies will provide new insights into the mechanisms of asthma, particularly severe disease, and possibilities of new approaches to treatment. ..