David Bushinsky

Summary

Affiliation: University of Rochester
Country: USA

Publications

  1. doi request reprint Contribution of intestine, bone, kidney, and dialysis to extracellular fluid calcium content
    David A Bushinsky
    Departments of Medicine and of Pharmacology and Physiology, University of Rochester School of Medicine, Rochester, New York, USA
    Clin J Am Soc Nephrol 5:S12-22. 2010
  2. pmc Nephrolithiasis: site of the initial solid phase
    David A Bushinsky
    University of Rochester School of Medicine and Dentistry and the Nephrology Unit, Strong Memorial Hospital, Rochester, New York 14642, USA
    J Clin Invest 111:602-5. 2003
  3. ncbi request reprint Chronic acidosis-induced alteration in bone bicarbonate and phosphate
    David A Bushinsky
    Department of Medicine, Univ of Rochester School of Medicine, NY 14642, USA
    Am J Physiol Renal Physiol 285:F532-9. 2003
  4. ncbi request reprint Effect of cinacalcet on urine calcium excretion and supersaturation in genetic hypercalciuric stone-forming rats
    D A Bushinsky
    Nephrology Division, Department of Medicine, University of Rochester School of Medicine, Rochester, New York, USA
    Kidney Int 69:1586-92. 2006
  5. ncbi request reprint Thiazides reduce brushite, but not calcium oxalate, supersaturation, and stone formation in genetic hypercalciuric stone-forming rats
    David A Bushinsky
    Department of Medicine, University of Rochester School of Medicine and Dentistry, Strong Memorial Hospital, 601 Elmwood Avenue, Box 675, Rochester, NY 14642, USA
    J Am Soc Nephrol 16:417-24. 2005
  6. doi request reprint Chlorthalidone improves vertebral bone quality in genetic hypercalciuric stone-forming rats
    David A Bushinsky
    Nephrology Division, Department of Medicine, University of Rochester School of Medicine, Rochester, NY 14642, USA
    J Bone Miner Res 26:1904-12. 2011
  7. ncbi request reprint Genetic hypercalciuric stone-forming rats
    David A Bushinsky
    Division of Nephrology, Department of Medicine, University of Rochester School of Medicine, Rochester, New York 14642, USA
    Curr Opin Nephrol Hypertens 15:403-18. 2006
  8. ncbi request reprint Phosphate binders: hold the calcium?
    David A Bushinsky
    Department of Medicine, University of Rochester School of Medicine, Nephrology Division, Strong Memorial Hospital, 601 Elmwood Avenue, Box 675, Rochester, NY 14642, USA
    Clin J Am Soc Nephrol 1:695-6. 2006
  9. ncbi request reprint Effect of bolus and divided feeding on urine ions and supersaturation in genetic hypercalciuric stone-forming rats
    D A Bushinsky
    Nephrology Division, Department of Medicine, University of Rochester School of Medicine, Rochester, New York 14642, USA
    Kidney Int 73:423-9. 2008
  10. ncbi request reprint Acute acidosis-induced alteration in bone bicarbonate and phosphate
    David A Bushinsky
    Nephrology Unit, Department of Medicine, University of Rochester School of Medicine, Rochester, New York 14642, USA
    Am J Physiol Renal Physiol 283:F1091-7. 2002

Research Grants

  1. Contribution of increased VDR and CaR to Hypercalciuria in the GHS Rat
    David A Bushinsky; Fiscal Year: 2010
  2. EFFECTS OF ACID ON BONE
    David Bushinsky; Fiscal Year: 2009
  3. EFFECTS OF ACID ON BONE
    David Bushinsky; Fiscal Year: 2007
  4. EFFECTS OF ACID ON BONE
    David Bushinsky; Fiscal Year: 2004
  5. EFFECTS OF ACID ON BONE
    David A Bushinsky; Fiscal Year: 2010

Detail Information

Publications47

  1. doi request reprint Contribution of intestine, bone, kidney, and dialysis to extracellular fluid calcium content
    David A Bushinsky
    Departments of Medicine and of Pharmacology and Physiology, University of Rochester School of Medicine, Rochester, New York, USA
    Clin J Am Soc Nephrol 5:S12-22. 2010
    ....
  2. pmc Nephrolithiasis: site of the initial solid phase
    David A Bushinsky
    University of Rochester School of Medicine and Dentistry and the Nephrology Unit, Strong Memorial Hospital, Rochester, New York 14642, USA
    J Clin Invest 111:602-5. 2003
  3. ncbi request reprint Chronic acidosis-induced alteration in bone bicarbonate and phosphate
    David A Bushinsky
    Department of Medicine, Univ of Rochester School of Medicine, NY 14642, USA
    Am J Physiol Renal Physiol 285:F532-9. 2003
    ..Thus a model of chronic acidosis depletes bulk bone proton buffers, with phosphate depletion exceeding that of HCO3(-)...
  4. ncbi request reprint Effect of cinacalcet on urine calcium excretion and supersaturation in genetic hypercalciuric stone-forming rats
    D A Bushinsky
    Nephrology Division, Department of Medicine, University of Rochester School of Medicine, Rochester, New York, USA
    Kidney Int 69:1586-92. 2006
    ..If these findings in GHS rats can be confirmed in man, it suggests that Cin would not be an effective agent in the treatment of human idiopathic hypercalciuria and resultant stone formation...
  5. ncbi request reprint Thiazides reduce brushite, but not calcium oxalate, supersaturation, and stone formation in genetic hypercalciuric stone-forming rats
    David A Bushinsky
    Department of Medicine, University of Rochester School of Medicine and Dentistry, Strong Memorial Hospital, 601 Elmwood Avenue, Box 675, Rochester, NY 14642, USA
    J Am Soc Nephrol 16:417-24. 2005
    ....
  6. doi request reprint Chlorthalidone improves vertebral bone quality in genetic hypercalciuric stone-forming rats
    David A Bushinsky
    Nephrology Division, Department of Medicine, University of Rochester School of Medicine, Rochester, NY 14642, USA
    J Bone Miner Res 26:1904-12. 2011
    ..CTD did not alter formation parameters, suggesting that the improved vertebral bone strength was due to decreased bone resorption and retention of bone structure...
  7. ncbi request reprint Genetic hypercalciuric stone-forming rats
    David A Bushinsky
    Division of Nephrology, Department of Medicine, University of Rochester School of Medicine, Rochester, New York 14642, USA
    Curr Opin Nephrol Hypertens 15:403-18. 2006
    ..We will describe the pathophysiology of hypercalciuria and the mechanism of the resultant stone formation in a rat model and draw parallels to human hypercalciuria and stone formation...
  8. ncbi request reprint Phosphate binders: hold the calcium?
    David A Bushinsky
    Department of Medicine, University of Rochester School of Medicine, Nephrology Division, Strong Memorial Hospital, 601 Elmwood Avenue, Box 675, Rochester, NY 14642, USA
    Clin J Am Soc Nephrol 1:695-6. 2006
  9. ncbi request reprint Effect of bolus and divided feeding on urine ions and supersaturation in genetic hypercalciuric stone-forming rats
    D A Bushinsky
    Nephrology Division, Department of Medicine, University of Rochester School of Medicine, Rochester, New York 14642, USA
    Kidney Int 73:423-9. 2008
    ..If these results are confirmed in man, it suggests that eating as a bolus may result in greater prandial and postprandial calcium oxalate supersaturation. This may increase growth on Randall's plaques and promote stone disease...
  10. ncbi request reprint Acute acidosis-induced alteration in bone bicarbonate and phosphate
    David A Bushinsky
    Nephrology Unit, Department of Medicine, University of Rochester School of Medicine, Rochester, New York 14642, USA
    Am J Physiol Renal Physiol 283:F1091-7. 2002
    ..Thus acute hydrogen ion buffering by bone involves preferential dissolution of surface HCO(3)(-) and of cross-sectional phosphate...
  11. ncbi request reprint Genetic hypercalciuric stone-forming rats
    D A Bushinsky
    University of Rochester School of Medicine and Dentistry, Strong Memorial Hospital, Rochester, NY 14642, USA
    Curr Opin Nephrol Hypertens 8:479-88. 1999
    ..Hypercalciuric rats appear to be an excellent model to provide insights into the mechanisms causing hypercalciuria, and to delineate treatments for stone disease...
  12. ncbi request reprint Metabolic, but not respiratory, acidosis increases bone PGE(2) levels and calcium release
    D A Bushinsky
    Nephrology Unit, Department of Medicine, University of Rochester School of Medicine, Rochester, New York 14642, USA
    Am J Physiol Renal Physiol 281:F1058-66. 2001
    ..Thus metabolic, but not respiratory, acidosis induces the release of bone PGE(2), which mediates J(Ca) from bone...
  13. ncbi request reprint Effect of acidosis on urine supersaturation and stone formation in genetic hypercalciuric stone-forming rats
    D A Bushinsky
    Nephrology Unit, University of Rochester School of Medicine, Rochester, New York 14642, USA
    Kidney Int 59:1415-23. 2001
    ....
  14. ncbi request reprint The effects of acid on bone
    D A Bushinsky
    Department of Medicine, University of Rochester School of Medicine, New York, USA
    Curr Opin Nephrol Hypertens 9:369-79. 2000
    ..Osteoblastic immediate early response genes are inhibited as are genes controlling matrix formation...
  15. ncbi request reprint Effects of in vivo metabolic acidosis on midcortical bone ion composition
    D A Bushinsky
    Nephrology Unit, Department of Medicine, University of Rochester School of Medicine, Rochester, New York 14642, USA
    Am J Physiol 277:F813-9. 1999
    ..Each of these mechanisms would result in buffering of the excess protons and returning the systemic pH toward normal...
  16. ncbi request reprint Increased dietary oxalate does not increase urinary calcium oxalate saturation in hypercalciuric rats
    D A Bushinsky
    Nephrology Unit, University of Rochester, New York, USA
    Kidney Int 55:602-12. 1999
    ..However, dietary oxalate also binds intestinal calcium which lowers calcium absorption and excretion. The effect of increasing dietary oxalate on urinary CaOx supersaturation is difficult to predict...
  17. ncbi request reprint Acid-base imbalance and the skeleton
    D A Bushinsky
    University of Rochester School of Medicine and Dentistry, Nephrology Unit, Strong Memorial Hospital, New York 14642, USA
    Eur J Nutr 40:238-44. 2001
    ..We hypothesize that a slight, but significant, metabolic acidosis leads to greater loss of bone mineral and increase potential to fracture...
  18. ncbi request reprint Calcium phosphate supersaturation regulates stone formation in genetic hypercalciuric stone-forming rats
    D A Bushinsky
    Nephrology Unit, University of Rochester School of Medicine, Rochester, NY 14642, USA
    Kidney Int 57:550-60. 2000
    ..We used these hypercalciuric (GHS) rats to test the hypothesis that an isolated reduction in urine supersaturation, achieved by decreasing urine phosphorus excretion, would decrease stone formation in these rats...
  19. ncbi request reprint Regulation of COX-2 mediates acid-induced bone calcium efflux in vitro
    Nancy S Krieger
    Department of Medicine, Division of Nephrology, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    J Bone Miner Res 22:907-17. 2007
    ..We report here that acidosis increases both osteoblastic RNA and protein levels for COX-2 and that genetic deficiency or pharmacologic inhibition of COX-2 significantly reduces acid-induced Ca efflux from bone...
  20. ncbi request reprint Mechanism of acid-induced bone resorption
    Nancy S Krieger
    Nephrology Unit, Department of Medicine, University of Rochester School of Medicine, Rochester, New York, USA
    Curr Opin Nephrol Hypertens 13:423-36. 2004
    ..This review presents our current understanding of the way metabolic acidosis induces calcium efflux from bone, and in the process, buffers additional systemic hydrogen ions associated with acidosis...
  21. ncbi request reprint Uric acid nephrolithiasis
    Scott E Liebman
    University of Rochester School of Medicine and Dentistry, Nephrology Division, Strong Memorial Hospital, Rochester, NY 14642, USA
    Curr Rheumatol Rep 9:251-7. 2007
    ..Patients with documented hyperuricemia often require specific therapy to lower serum uric acid concentration and subsequent excretion...
  22. ncbi request reprint Cortisol inhibits acid-induced bone resorption in vitro
    Nancy S Krieger
    Department of Medicine, Nephrology Unit, University of Rochester School of Medicine, Rochester, New York 14642, USA
    J Am Soc Nephrol 13:2534-9. 2002
    ..These results suggest that the osteopenia observed in response to metabolic acidosis in vivo is not due to an increase in endogenous cortisol production...
  23. doi request reprint When is it appropriate to order an ionized calcium?
    Laura M Calvi
    Department of Medicine, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Box 693, Rochester, NY 14642, USA
    J Am Soc Nephrol 19:1257-60. 2008
    ..Also examined are available data illustrating the settings in which measurement of ionized calcium is preferred and, in some cases, necessary for clinical decision-making...
  24. ncbi request reprint Mechanism and function of high vitamin D receptor levels in genetic hypercalciuric stone-forming rats
    Alexander J Karnauskas
    Department of Medicine, University of Chicago Pritzker School of Medicine, Chicago, Illinois 60637, USA
    J Bone Miner Res 20:447-54. 2005
    ..1,25(OH)(2)D(3) increased VDR and calbindins in controls but not GHS rats. VDR half-life was prolonged in GHS rats. This study supports the mechanism and functional status of elevated VDR in GHS rats...
  25. doi request reprint Calcium and phosphorus homeostasis
    Jeremy G Taylor
    Division of Nephrology, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Blood Purif 27:387-94. 2009
    ..In this review we discuss the current understanding of the relationships between the ions, hormones, and transporters that maintain calcium and phosphorus homeostasis...
  26. pmc Effect of metabolic and respiratory acidosis on intracellular calcium in osteoblasts
    Kevin K Frick
    Department of Medicine, University of Rochester School of Medicine and Dentistry, New York 14642, USA
    Am J Physiol Renal Physiol 299:F418-25. 2010
    ....
  27. pmc Pharmacological inhibition of intracellular calcium release blocks acid-induced bone resorption
    Nancy S Krieger
    University of Rochester School of Medicine and Dentistry, Division of Nephrology, Department of Medicine, 601 Elmwood Ave, Box 675, Rochester, NY 14642, USA
    Am J Physiol Renal Physiol 300:F91-7. 2011
    ..These results support the hypothesis that H+ stimulation of net Ca2+ efflux from bone, mediated by COX2- and subsequent PGE2-induced RANKL production, is initiated in the osteoblast via activation of Ca2+ signaling...
  28. pmc Metabolic acidosis increases intracellular calcium in bone cells through activation of the proton receptor OGR1
    Kevin K Frick
    Division of Nephrology, Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    J Bone Miner Res 24:305-13. 2009
    ..Perfusion with MET induced a rapid increase in Ca(i) in OGR1-transfected CHO cells. These data indicate that OGR1 induces an increase in Ca(i) in response to MET and is a prime candidate for an osteoblast proton sensor...
  29. ncbi request reprint Idiopathic hypercalciuria
    Scott E Liebman
    University of Rochester School of Medicine and Dentistry, Nephrology Division, Strong Memorial Hospital, 601 Elmwood Avenue, Box 675, Rochester, NY 14642, USA
    Curr Rheumatol Rep 8:70-5. 2006
    ..It is important to note that while decreasing urinary calcium excretion is important the clinician should focus primarily on reducing the supersaturation of calcium oxalate as this determines the true tendency for stone formation...
  30. ncbi request reprint Calcium oxalate stone formation in genetic hypercalciuric stone-forming rats
    David A Bushinsky
    Department of Medicine, Nephrology Unit, University of Rochester School of Medicine, Strong Memorial Hospital, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Kidney Int 61:975-87. 2002
    ....
  31. ncbi request reprint Molecular mechanisms of primary hypercalciuria
    Kevin K Frick
    Department of Medicine, Nephrology Unit, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    J Am Soc Nephrol 14:1082-95. 2003
  32. ncbi request reprint Metabolic acidosis stimulates RANKL RNA expression in bone through a cyclo-oxygenase-dependent mechanism
    Kevin K Frick
    Department of Medicine, Nephrology Unit, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    J Bone Miner Res 18:1317-25. 2003
    ..Acidosis resulted in a significant cyclo-oxygenase-dependent increase in RANKL RNA levels, which would be expected to induce the associated increase in bone resorption...
  33. ncbi request reprint Cellular mechanisms of bone resorption induced by metabolic acidosis
    Nancy S Krieger
    Nephrology Unit, Department of Medicine, University of Rochester School of Medicine, Rochester, New York 14642, USA
    Semin Dial 16:463-6. 2003
    ..Both responses were inhibited in the presence of indomethacin. Thus metabolic, but not respiratory, acidosis induces production of bone PGE2, which mediates acid-induced bone resorption...
  34. ncbi request reprint RANK ligand and TNF-alpha mediate acid-induced bone calcium efflux in vitro
    Kevin K Frick
    Nephrology Division, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Am J Physiol Renal Physiol 289:F1005-11. 2005
    ....
  35. ncbi request reprint First- and second-generation immunometric PTH assays during treatment of hyperparathyroidism with cinacalcet HCl
    Kevin J Martin
    Division of Nephrology, Saint Louis University, St Louis, Missouri 63110, USA
    Kidney Int 68:1236-43. 2005
    ..This study compared iPTH and biPTH assays during cinacalcet treatment in subjects with secondary HPT receiving dialysis...
  36. ncbi request reprint Isolation and confirmation of a calcium excretion quantitative trait locus on chromosome 1 in genetic hypercalciuric stone-forming congenic rats
    Richard R Hoopes
    Department of Medicine, SUNY Upstate Medical University, 750 E Adams Street, Syracuse, NY 13210, USA
    J Am Soc Nephrol 17:1292-304. 2006
    ..This is the first QTL for hypercalciuria to be isolated in a congenic animal...
  37. ncbi request reprint Quantitative trait loci for hypercalciuria in a rat model of kidney stone disease
    Richard R Hoopes
    Department of Medicine, State University of New York Upstate Medical University, 750 East Adams Street, Syracuse, NY 13210, USA
    J Am Soc Nephrol 14:1844-50. 2003
    ..Identification of genes that contribute to hypercalciuria in this animal model should prove valuable in understanding idiopathic hypercalciuria and kidney stone disease in humans...
  38. ncbi request reprint Elevated calcium phosphate product after renal transplantation is a risk factor for graft failure
    Ogo I Egbuna
    Division of Nephrology, Beth Israel Deaconess Medical Center, and Division of Endocrinology and Hypertension Calcium and Parathyroid Physiology Laboratory, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Clin Transplant 21:558-66. 2007
    ..The effect of these abnormalities on recipient and graft survival after renal transplantation is unknown...
  39. ncbi request reprint Bone buffering of acid and base in humans
    Jacob Lemann
    Nephrology Section, Tulane University School of Medicine, 2601 St Charles Ave, New Orleans, LA 70130 5927, USA
    Am J Physiol Renal Physiol 285:F811-32. 2003
    ..These charge balances are likely the result of the adsorption of HCO3- onto the crystal surfaces of bone mineral. There do not appear to be significant errors in the measurements...
  40. ncbi request reprint The calcimimetic AMG 073 as a potential treatment for secondary hyperparathyroidism of end-stage renal disease
    L Darryl Quarles
    Duke University Medical Center, Durham, North Carolina 27710, USA
    J Am Soc Nephrol 14:575-83. 2003
    ..AMG 073 represents a novel and promising therapy to improve the management of secondary hyperparathyroidism...
  41. ncbi request reprint Recurrent hypercalciuric nephrolithiasis--does diet help?
    David A Bushinsky
    N Engl J Med 346:124-5. 2002
  42. doi request reprint Nutritional vitamin D: the benefits of supplementation
    David A Bushinsky
    Curr Opin Nephrol Hypertens 17:345-7. 2008
  43. doi request reprint Combined therapy with cinacalcet and low doses of vitamin D sterols in patients with moderate to severe secondary hyperparathyroidism
    Geoffrey A Block
    Denver Nephrologists, Denver, CO 80230, USA
    Nephrol Dial Transplant 23:2311-8. 2008
    ....
  44. pmc Recent developments in our understanding of the renal basis of hyperuricemia and the development of novel antihyperuricemic therapeutics
    Robert Terkeltaub
    San Diego VAMC Rheumatology Section, and University of California San Diego, La Jolla, California, USA
    Arthritis Res Ther 8:S4. 2006
    ..For this reason, our discussion focuses on the development of the novel xanthine oxidase inhibitor febuxostat and modified recombinant uricase preparations...
  45. ncbi request reprint Calcium oxalate crystal localization and osteopontin immunostaining in genetic hypercalciuric stone-forming rats
    Andrew P Evan
    Anatomy Department, Indiana University School of Medicine, Indianapolis, Indiana, USA
    Kidney Int 65:154-61. 2004
    ..The present study was designed to determine the localization of stone formation and if this solid phase resulted in pathologic changes to the kidneys...
  46. ncbi request reprint Regulation of renal calcium receptor gene expression by 1,25-dihydroxyvitamin D3 in genetic hypercalciuric stone-forming rats
    Jim J Yao
    The University of Chicago, Pritzker School of Medicine, 5841 S Maryland Avenue, MC 1027, Chicago, Illinois 60637, USA
    J Am Soc Nephrol 16:1300-8. 2005
    ..These results demonstrate that GHS rats have high levels of CaR gene expression and CaR protein that may contribute to the hypercalciuria and calcium nephrolithiasis...
  47. ncbi request reprint Sustained, long-term renal stabilization after 54 months of agalsidase beta therapy in patients with Fabry disease
    Dominique P Germain
    Assistance Publique Hopitaux de Paris, Paris, France
    J Am Soc Nephrol 18:1547-57. 2007
    ..Long-term agalsidase beta therapy stabilizes renal function in patients without renal involvement at baseline, maintains reduction of plasma GL-3, and sustains GL-3 clearance in capillary endothelial cells and multiple renal cell types...

Research Grants12

  1. Contribution of increased VDR and CaR to Hypercalciuria in the GHS Rat
    David A Bushinsky; Fiscal Year: 2010
    ..These studies will advance research on hypercalciuria and may ultimately lead to improved care of patients with kidney stones. ..
  2. EFFECTS OF ACID ON BONE
    David Bushinsky; Fiscal Year: 2009
    ..The current proposal is aimed at understanding the first steps by which acid is detected by bone cells. Understanding the process by which the bone detects and neutralizes the acid can lead to an improvement in bone health. ..
  3. EFFECTS OF ACID ON BONE
    David Bushinsky; Fiscal Year: 2007
    ..The current proposal is aimed at understanding the first steps by which acid is detected by bone cells. Understanding the process by which the bone detects and neutralizes the acid can lead to an improvement in bone health. ..
  4. EFFECTS OF ACID ON BONE
    David Bushinsky; Fiscal Year: 2004
    ..Our long term goal is to develop a model to describe how acidosis affects bone in order to devise therapy to preserve mineral while maintaining the H+ buffering properties of bone. ..
  5. EFFECTS OF ACID ON BONE
    David A Bushinsky; Fiscal Year: 2010
    ..The current proposal is aimed at understanding the first steps by which acid is detected by bone cells. Understanding the process by which the bone detects and neutralizes the acid can lead to an improvement in bone health. ..