Research Topics
| David BushinskySummaryAffiliation: University of Rochester Country: USA Publications
Research Grants
| Collaborators
|
Detail Information
Publications
Contribution of intestine, bone, kidney, and dialysis to extracellular fluid calcium contentDavid A Bushinsky
Departments of Medicine and of Pharmacology and Physiology, University of Rochester School of Medicine, Rochester, New York, USA
Clin J Am Soc Nephrol 5:S12-22. 2010....- Nephrolithiasis: site of the initial solid phaseDavid A Bushinsky
University of Rochester School of Medicine and Dentistry and the Nephrology Unit, Strong Memorial Hospital, Rochester, New York 14642, USA
J Clin Invest 111:602-5. 2003 - Chronic acidosis-induced alteration in bone bicarbonate and phosphateDavid A Bushinsky
Department of Medicine, Univ of Rochester School of Medicine, NY 14642, USA
Am J Physiol Renal Physiol 285:F532-9. 2003..Thus a model of chronic acidosis depletes bulk bone proton buffers, with phosphate depletion exceeding that of HCO3(-)... - Effect of cinacalcet on urine calcium excretion and supersaturation in genetic hypercalciuric stone-forming ratsD A Bushinsky
Nephrology Division, Department of Medicine, University of Rochester School of Medicine, Rochester, New York, USA
Kidney Int 69:1586-92. 2006..If these findings in GHS rats can be confirmed in man, it suggests that Cin would not be an effective agent in the treatment of human idiopathic hypercalciuria and resultant stone formation... - Thiazides reduce brushite, but not calcium oxalate, supersaturation, and stone formation in genetic hypercalciuric stone-forming ratsDavid A Bushinsky
Department of Medicine, University of Rochester School of Medicine and Dentistry, Strong Memorial Hospital, 601 Elmwood Avenue, Box 675, Rochester, NY 14642, USA
J Am Soc Nephrol 16:417-24. 2005.... - Chlorthalidone improves vertebral bone quality in genetic hypercalciuric stone-forming ratsDavid A Bushinsky
Nephrology Division, Department of Medicine, University of Rochester School of Medicine, Rochester, NY 14642, USA
J Bone Miner Res 26:1904-12. 2011..CTD did not alter formation parameters, suggesting that the improved vertebral bone strength was due to decreased bone resorption and retention of bone structure... - Genetic hypercalciuric stone-forming ratsDavid A Bushinsky
Division of Nephrology, Department of Medicine, University of Rochester School of Medicine, Rochester, New York 14642, USA
Curr Opin Nephrol Hypertens 15:403-18. 2006..We will describe the pathophysiology of hypercalciuria and the mechanism of the resultant stone formation in a rat model and draw parallels to human hypercalciuria and stone formation... - Phosphate binders: hold the calcium?David A Bushinsky
Department of Medicine, University of Rochester School of Medicine, Nephrology Division, Strong Memorial Hospital, 601 Elmwood Avenue, Box 675, Rochester, NY 14642, USA
Clin J Am Soc Nephrol 1:695-6. 2006 - Effect of bolus and divided feeding on urine ions and supersaturation in genetic hypercalciuric stone-forming ratsD A Bushinsky
Nephrology Division, Department of Medicine, University of Rochester School of Medicine, Rochester, New York 14642, USA
Kidney Int 73:423-9. 2008..If these results are confirmed in man, it suggests that eating as a bolus may result in greater prandial and postprandial calcium oxalate supersaturation. This may increase growth on Randall's plaques and promote stone disease... - Acute acidosis-induced alteration in bone bicarbonate and phosphateDavid A Bushinsky
Nephrology Unit, Department of Medicine, University of Rochester School of Medicine, Rochester, New York 14642, USA
Am J Physiol Renal Physiol 283:F1091-7. 2002..Thus acute hydrogen ion buffering by bone involves preferential dissolution of surface HCO(3)(-) and of cross-sectional phosphate... - Genetic hypercalciuric stone-forming ratsD A Bushinsky
University of Rochester School of Medicine and Dentistry, Strong Memorial Hospital, Rochester, NY 14642, USA
Curr Opin Nephrol Hypertens 8:479-88. 1999..Hypercalciuric rats appear to be an excellent model to provide insights into the mechanisms causing hypercalciuria, and to delineate treatments for stone disease... - Metabolic, but not respiratory, acidosis increases bone PGE(2) levels and calcium releaseD A Bushinsky
Nephrology Unit, Department of Medicine, University of Rochester School of Medicine, Rochester, New York 14642, USA
Am J Physiol Renal Physiol 281:F1058-66. 2001..Thus metabolic, but not respiratory, acidosis induces the release of bone PGE(2), which mediates J(Ca) from bone... - Effect of acidosis on urine supersaturation and stone formation in genetic hypercalciuric stone-forming ratsD A Bushinsky
Nephrology Unit, University of Rochester School of Medicine, Rochester, New York 14642, USA
Kidney Int 59:1415-23. 2001.... - The effects of acid on boneD A Bushinsky
Department of Medicine, University of Rochester School of Medicine, New York, USA
Curr Opin Nephrol Hypertens 9:369-79. 2000..Osteoblastic immediate early response genes are inhibited as are genes controlling matrix formation... - Effects of in vivo metabolic acidosis on midcortical bone ion compositionD A Bushinsky
Nephrology Unit, Department of Medicine, University of Rochester School of Medicine, Rochester, New York 14642, USA
Am J Physiol 277:F813-9. 1999..Each of these mechanisms would result in buffering of the excess protons and returning the systemic pH toward normal... - Increased dietary oxalate does not increase urinary calcium oxalate saturation in hypercalciuric ratsD A Bushinsky
Nephrology Unit, University of Rochester, New York, USA
Kidney Int 55:602-12. 1999..However, dietary oxalate also binds intestinal calcium which lowers calcium absorption and excretion. The effect of increasing dietary oxalate on urinary CaOx supersaturation is difficult to predict... - Acid-base imbalance and the skeletonD A Bushinsky
University of Rochester School of Medicine and Dentistry, Nephrology Unit, Strong Memorial Hospital, New York 14642, USA
Eur J Nutr 40:238-44. 2001..We hypothesize that a slight, but significant, metabolic acidosis leads to greater loss of bone mineral and increase potential to fracture... - Calcium phosphate supersaturation regulates stone formation in genetic hypercalciuric stone-forming ratsD A Bushinsky
Nephrology Unit, University of Rochester School of Medicine, Rochester, NY 14642, USA
Kidney Int 57:550-60. 2000..We used these hypercalciuric (GHS) rats to test the hypothesis that an isolated reduction in urine supersaturation, achieved by decreasing urine phosphorus excretion, would decrease stone formation in these rats... - Regulation of COX-2 mediates acid-induced bone calcium efflux in vitroNancy S Krieger
Department of Medicine, Division of Nephrology, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
J Bone Miner Res 22:907-17. 2007..We report here that acidosis increases both osteoblastic RNA and protein levels for COX-2 and that genetic deficiency or pharmacologic inhibition of COX-2 significantly reduces acid-induced Ca efflux from bone... - Mechanism of acid-induced bone resorptionNancy S Krieger
Nephrology Unit, Department of Medicine, University of Rochester School of Medicine, Rochester, New York, USA
Curr Opin Nephrol Hypertens 13:423-36. 2004..The apparent protective function of bone to help maintain systemic pH, which has a clear survival advantage for mammals, will come partly at the expense of its mineral stores... - Uric acid nephrolithiasisScott E Liebman
University of Rochester School of Medicine and Dentistry, Nephrology Division, Strong Memorial Hospital, Rochester, NY 14642, USA
Curr Rheumatol Rep 9:251-7. 2007..Patients with documented hyperuricemia often require specific therapy to lower serum uric acid concentration and subsequent excretion... - Cortisol inhibits acid-induced bone resorption in vitroNancy S Krieger
Department of Medicine, Nephrology Unit, University of Rochester School of Medicine, Rochester, New York 14642, USA
J Am Soc Nephrol 13:2534-9. 2002..These results suggest that the osteopenia observed in response to metabolic acidosis in vivo is not due to an increase in endogenous cortisol production... - When is it appropriate to order an ionized calcium?Laura M Calvi
Department of Medicine, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Box 693, Rochester, NY 14642, USA
J Am Soc Nephrol 19:1257-60. 2008..Also examined are available data illustrating the settings in which measurement of ionized calcium is preferred and, in some cases, necessary for clinical decision-making... - Mechanism and function of high vitamin D receptor levels in genetic hypercalciuric stone-forming ratsAlexander J Karnauskas
Department of Medicine, University of Chicago Pritzker School of Medicine, Chicago, Illinois 60637, USA
J Bone Miner Res 20:447-54. 2005.... - Calcium and phosphorus homeostasisJeremy G Taylor
Division of Nephrology, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, NY 14642, USA
Blood Purif 27:387-94. 2009..In this review we discuss the current understanding of the relationships between the ions, hormones, and transporters that maintain calcium and phosphorus homeostasis... - Effect of metabolic and respiratory acidosis on intracellular calcium in osteoblastsKevin K Frick
Department of Medicine, University of Rochester School of Medicine and Dentistry, New York 14642, USA
Am J Physiol Renal Physiol 299:F418-25. 2010.... - Pharmacological inhibition of intracellular calcium release blocks acid-induced bone resorptionNancy S Krieger
University of Rochester School of Medicine and Dentistry, Division of Nephrology, Department of Medicine, 601 Elmwood Ave, Box 675, Rochester, NY 14642, USA
Am J Physiol Renal Physiol 300:F91-7. 2011..These results support the hypothesis that H+ stimulation of net Ca2+ efflux from bone, mediated by COX2- and subsequent PGE2-induced RANKL production, is initiated in the osteoblast via activation of Ca2+ signaling... - Metabolic acidosis increases intracellular calcium in bone cells through activation of the proton receptor OGR1Kevin K Frick
Division of Nephrology, Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
J Bone Miner Res 24:305-13. 2009..Perfusion with MET induced a rapid increase in Ca(i) in OGR1-transfected CHO cells. These data indicate that OGR1 induces an increase in Ca(i) in response to MET and is a prime candidate for an osteoblast proton sensor... - Idiopathic hypercalciuriaScott E Liebman
University of Rochester School of Medicine and Dentistry, Nephrology Division, Strong Memorial Hospital, 601 Elmwood Avenue, Box 675, Rochester, NY 14642, USA
Curr Rheumatol Rep 8:70-5. 2006..It is important to note that while decreasing urinary calcium excretion is important the clinician should focus primarily on reducing the supersaturation of calcium oxalate as this determines the true tendency for stone formation... - Calcium oxalate stone formation in genetic hypercalciuric stone-forming ratsDavid A Bushinsky
Department of Medicine, Nephrology Unit, University of Rochester School of Medicine, Strong Memorial Hospital, 601 Elmwood Avenue, Rochester, NY 14642, USA
Kidney Int 61:975-87. 2002.... - Molecular mechanisms of primary hypercalciuriaKevin K Frick
Department of Medicine, Nephrology Unit, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
J Am Soc Nephrol 14:1082-95. 2003 - Metabolic acidosis stimulates RANKL RNA expression in bone through a cyclo-oxygenase-dependent mechanismKevin K Frick
Department of Medicine, Nephrology Unit, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
J Bone Miner Res 18:1317-25. 2003..Acidosis resulted in a significant cyclo-oxygenase-dependent increase in RANKL RNA levels, which would be expected to induce the associated increase in bone resorption... - Cellular mechanisms of bone resorption induced by metabolic acidosisNancy S Krieger
Nephrology Unit, Department of Medicine, University of Rochester School of Medicine, Rochester, New York 14642, USA
Semin Dial 16:463-6. 2003..Both responses were inhibited in the presence of indomethacin. Thus metabolic, but not respiratory, acidosis induces production of bone PGE2, which mediates acid-induced bone resorption... - RANK ligand and TNF-alpha mediate acid-induced bone calcium efflux in vitroKevin K Frick
Nephrology Division, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
Am J Physiol Renal Physiol 289:F1005-11. 2005.... - First- and second-generation immunometric PTH assays during treatment of hyperparathyroidism with cinacalcet HClKevin J Martin
Division of Nephrology, Saint Louis University, St Louis, Missouri 63110, USA
Kidney Int 68:1236-43. 2005..This study compared iPTH and biPTH assays during cinacalcet treatment in subjects with secondary HPT receiving dialysis... - Isolation and confirmation of a calcium excretion quantitative trait locus on chromosome 1 in genetic hypercalciuric stone-forming congenic ratsRichard R Hoopes
Department of Medicine, SUNY Upstate Medical University, 750 E Adams Street, Syracuse, NY 13210, USA
J Am Soc Nephrol 17:1292-304. 2006..This is the first QTL for hypercalciuria to be isolated in a congenic animal... - Quantitative trait loci for hypercalciuria in a rat model of kidney stone diseaseRichard R Hoopes
Department of Medicine, State University of New York Upstate Medical University, 750 East Adams Street, Syracuse, NY 13210, USA
J Am Soc Nephrol 14:1844-50. 2003..Identification of genes that contribute to hypercalciuria in this animal model should prove valuable in understanding idiopathic hypercalciuria and kidney stone disease in humans... - Elevated calcium phosphate product after renal transplantation is a risk factor for graft failureOgo I Egbuna
Division of Nephrology, Beth Israel Deaconess Medical Center, and Division of Endocrinology and Hypertension Calcium and Parathyroid Physiology Laboratory, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
Clin Transplant 21:558-66. 2007..The effect of these abnormalities on recipient and graft survival after renal transplantation is unknown... - Bone buffering of acid and base in humansJacob Lemann
Nephrology Section, Tulane University School of Medicine, 2601 St Charles Ave, New Orleans, LA 70130 5927, USA
Am J Physiol Renal Physiol 285:F811-32. 2003..These charge balances are likely the result of the adsorption of HCO3- onto the crystal surfaces of bone mineral. There do not appear to be significant errors in the measurements... - The calcimimetic AMG 073 as a potential treatment for secondary hyperparathyroidism of end-stage renal diseaseL Darryl Quarles
Duke University Medical Center, Durham, North Carolina 27710, USA
J Am Soc Nephrol 14:575-83. 2003..AMG 073 represents a novel and promising therapy to improve the management of secondary hyperparathyroidism... - Recurrent hypercalciuric nephrolithiasis--does diet help?David A Bushinsky
N Engl J Med 346:124-5. 2002 - Nutritional vitamin D: the benefits of supplementationDavid A Bushinsky
Curr Opin Nephrol Hypertens 17:345-7. 2008 - Combined therapy with cinacalcet and low doses of vitamin D sterols in patients with moderate to severe secondary hyperparathyroidismGeoffrey A Block
Denver Nephrologists, Denver, CO 80230, USA
Nephrol Dial Transplant 23:2311-8. 2008.... - Recent developments in our understanding of the renal basis of hyperuricemia and the development of novel antihyperuricemic therapeuticsRobert Terkeltaub
San Diego VAMC Rheumatology Section, and University of California San Diego, La Jolla, California, USA
Arthritis Res Ther 8:S4. 2006..For this reason, our discussion focuses on the development of the novel xanthine oxidase inhibitor febuxostat and modified recombinant uricase preparations... - Calcium oxalate crystal localization and osteopontin immunostaining in genetic hypercalciuric stone-forming ratsAndrew P Evan
Anatomy Department, Indiana University School of Medicine, Indianapolis, Indiana, USA
Kidney Int 65:154-61. 2004.... - Regulation of renal calcium receptor gene expression by 1,25-dihydroxyvitamin D3 in genetic hypercalciuric stone-forming ratsJim J Yao
The University of Chicago, Pritzker School of Medicine, 5841 S. Maryland Avenue, MC 1027, Chicago, Illinois 60637, USA
J Am Soc Nephrol 16:1300-8. 2005..These results demonstrate that GHS rats have high levels of CaR gene expression and CaR protein that may contribute to the hypercalciuria and calcium nephrolithiasis... - Sustained, long-term renal stabilization after 54 months of agalsidase beta therapy in patients with Fabry diseaseDominique P Germain
Assistance Publique Hopitaux de Paris, Paris, France
J Am Soc Nephrol 18:1547-57. 2007..Long-term agalsidase beta therapy stabilizes renal function in patients without renal involvement at baseline, maintains reduction of plasma GL-3, and sustains GL-3 clearance in capillary endothelial cells and multiple renal cell types...
Research Grants
- Contribution of increased VDR and CaR to Hypercalciuria in the GHS RatDavid A Bushinsky; Fiscal Year: 2010..These studies will advance research on hypercalciuria and may ultimately lead to improved care of patients with kidney stones. ..
- EFFECTS OF ACID ON BONEDavid Bushinsky; Fiscal Year: 2009..The current proposal is aimed at understanding the first steps by which acid is detected by bone cells. Understanding the process by which the bone detects and neutralizes the acid can lead to an improvement in bone health. ..
- EFFECTS OF ACID ON BONEDavid Bushinsky; Fiscal Year: 2007..The current proposal is aimed at understanding the first steps by which acid is detected by bone cells. Understanding the process by which the bone detects and neutralizes the acid can lead to an improvement in bone health. ..
- EFFECTS OF ACID ON BONEDavid Bushinsky; Fiscal Year: 2004..Our long term goal is to develop a model to describe how acidosis affects bone in order to devise therapy to preserve mineral while maintaining the H+ buffering properties of bone. ..
- EFFECTS OF ACID ON BONEDavid A Bushinsky; Fiscal Year: 2010..The current proposal is aimed at understanding the first steps by which acid is detected by bone cells. Understanding the process by which the bone detects and neutralizes the acid can lead to an improvement in bone health. ..