R M Bush

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Barriers to antigenic escape by pathogens: trade-off between reproductive rate and antigenic mutability
    Steven A Frank
    Department of Ecology and Evolutionary Biology, University of California, Irvine, CA 92697 2525, USA
    BMC Evol Biol 7:229. 2007
  2. ncbi request reprint Positive selection on the H3 hemagglutinin gene of human influenza virus A
    R M Bush
    Department of Ecology and Evolutionary Biology, University of California at Irvine 92697, USA
    Mol Biol Evol 16:1457-65. 1999
  3. ncbi request reprint Predicting the evolution of human influenza A
    R M Bush
    Department of Ecology and Evolutionary Biology, University of California, Irvine, CA 92697, USA
    Science 286:1921-5. 1999
  4. pmc Effects of passage history and sampling bias on phylogenetic reconstruction of human influenza A evolution
    R M Bush
    Department of Ecology and Evolutionary Biology, University of California, Irvine, CA 92697, USA
    Proc Natl Acad Sci U S A 97:6974-80. 2000
  5. pmc Influenza as a model system for studying the cross-species transfer and evolution of the SARS coronavirus
    Robin M Bush
    Department of Ecology and Evolutionary Biology, 321 Steinhaus, University of California, Irvine, CA 92697, USA
    Philos Trans R Soc Lond B Biol Sci 359:1067-73. 2004
  6. ncbi request reprint The Wilhelmine E. Key 1999 Invitational lecture. Predicting the evolution of human influenza A
    W M Fitch
    Department of Ecology and Evolutionary Biology, University of California, Irvine 92697, USA
    J Hered 91:183-5. 2000
  7. pmc Quantifying interhospital patient sharing as a mechanism for infectious disease spread
    Susan S Huang
    Division of Infectious Diseases and Health Policy Research Institute, University of California Irvine, Irvine, California, USA
    Infect Control Hosp Epidemiol 31:1160-9. 2010
  8. ncbi request reprint Molecular evolution of the Chlamydiaceae
    R M Bush
    Department of Ecology and Evolutionary Biology, University of California, Irvine 92697, USA
    Int J Syst Evol Microbiol 51:203-20. 2001
  9. ncbi request reprint Ecological and immunological determinants of influenza evolution
    Neil M Ferguson
    Department of Infectious Disease Epidemiology, Faculty of Medicine, Imperial College London, St Mary s Campus, Norfolk Place, London W2 1PG, UK
    Nature 422:428-33. 2003

Research Grants

Detail Information

Publications9

  1. pmc Barriers to antigenic escape by pathogens: trade-off between reproductive rate and antigenic mutability
    Steven A Frank
    Department of Ecology and Evolutionary Biology, University of California, Irvine, CA 92697 2525, USA
    BMC Evol Biol 7:229. 2007
    ..Both measles and influenza are RNA viruses with high mutation rates, so the mutation rate alone cannot explain the differences in antigenic variability...
  2. ncbi request reprint Positive selection on the H3 hemagglutinin gene of human influenza virus A
    R M Bush
    Department of Ecology and Evolutionary Biology, University of California at Irvine 92697, USA
    Mol Biol Evol 16:1457-65. 1999
    ..Our results suggest that future studies of positive selection should focus on changes assigned to the internal branches, as certain of these changes may have predictive value for identifying future successful epidemic variants...
  3. ncbi request reprint Predicting the evolution of human influenza A
    R M Bush
    Department of Ecology and Evolutionary Biology, University of California, Irvine, CA 92697, USA
    Science 286:1921-5. 1999
    ..However, not all codons in these sites had predictive value. Monitoring new H3 isolates for additional changes in positively selected codons might help identify the most fit extant viral strains that arise during antigenic drift...
  4. pmc Effects of passage history and sampling bias on phylogenetic reconstruction of human influenza A evolution
    R M Bush
    Department of Ecology and Evolutionary Biology, University of California, Irvine, CA 92697, USA
    Proc Natl Acad Sci U S A 97:6974-80. 2000
    ..However, if possible, the excess caused by host-mediated mutations should be removed from studies of the evolution of influenza viruses as they replicate in their human hosts...
  5. pmc Influenza as a model system for studying the cross-species transfer and evolution of the SARS coronavirus
    Robin M Bush
    Department of Ecology and Evolutionary Biology, 321 Steinhaus, University of California, Irvine, CA 92697, USA
    Philos Trans R Soc Lond B Biol Sci 359:1067-73. 2004
    ..Although influenza A and SARS-CoV differ in many ways, our knowledge of influenza A may provide important clues about what limits or favours cross-species transfers and subsequent epidemics of newly emerging pathogens...
  6. ncbi request reprint The Wilhelmine E. Key 1999 Invitational lecture. Predicting the evolution of human influenza A
    W M Fitch
    Department of Ecology and Evolutionary Biology, University of California, Irvine 92697, USA
    J Hered 91:183-5. 2000
    ..However, not all codons in these sites had predictive value. Monitoring new H3 isolates for additional changes in positively selected codons might help identify the most fit extant viral strains that arise during antigenic drift...
  7. pmc Quantifying interhospital patient sharing as a mechanism for infectious disease spread
    Susan S Huang
    Division of Infectious Diseases and Health Policy Research Institute, University of California Irvine, Irvine, California, USA
    Infect Control Hosp Epidemiol 31:1160-9. 2010
    ..Assessments of infectious disease spread in hospitals seldom account for interfacility patient sharing. This is particularly important for pathogens with prolonged incubation periods or carrier states...
  8. ncbi request reprint Molecular evolution of the Chlamydiaceae
    R M Bush
    Department of Ecology and Evolutionary Biology, University of California, Irvine 92697, USA
    Int J Syst Evol Microbiol 51:203-20. 2001
    ....
  9. ncbi request reprint Ecological and immunological determinants of influenza evolution
    Neil M Ferguson
    Department of Infectious Disease Epidemiology, Faculty of Medicine, Imperial College London, St Mary s Campus, Norfolk Place, London W2 1PG, UK
    Nature 422:428-33. 2003
    ....

Research Grants7

  1. Predicting the Evolution of Human Influenza
    Robin Bush; Fiscal Year: 2006
    ..4) The generality of the results from study of H3N2 will be tested by contrasting them with similar studies of influenza A subtype H1N1 and influenza B. ..
  2. Computational Models of Pathogen Evolution and Vaccinat*
    Robin Bush; Fiscal Year: 2007
    ..This research will also expand the range of vaccination strategies for use against rapidly evolving pathogens such as influenza. ..