Research Topics
| Theresa BuschSummaryAffiliation: University of Pennsylvania Country: USA Publications
Research Grants
| Collaborators
|
Detail Information
Publications
Hypoxia and Photofrin uptake in the intraperitoneal carcinomatosis and sarcomatosis of photodynamic therapy patientsTheresa M Busch
Department of Radiation Oncology, Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania, USA
Clin Cancer Res 10:4630-8. 2004..The goal of this study was to investigate the presence of hypoxia and retention of the photosensitizer Photofrin in the tumors of patients with intra-abdominal carcinomatosis or sarcomatosis...- Quantitative spatial analysis of hypoxia and vascular perfusion in tumor sectionsTheresa M Busch
Department of Radiation Oncology, School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
Adv Exp Med Biol 510:37-43. 2003 
Increasing damage to tumor blood vessels during motexafin lutetium-PDT through use of low fluence rateTheresa M Busch
Department of Radiation Oncology, School of Medicine, University of Pennsylvania Philadelphia, Pennsylvania 19104, USA
Radiat Res 174:331-40. 2010..Further study of low fluence rate as a means to improve responses to PDT under conditions designed to predominantly damage vasculature is warranted...- Local physiological changes during photodynamic therapyTheresa M Busch
Department of Radiation Oncology, School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6072, USA
Lasers Surg Med 38:494-9. 2006..Herein an overview is provided of the causes, consequences, and significance of photodynamic therapy (PDT)-mediated effects on tumor oxygenation and blood flow during illumination... - Fluence rate-dependent intratumor heterogeneity in physiologic and cytotoxic responses to Photofrin photodynamic therapyTheresa M Busch
Department of Radiation Oncology, School of Medicine, University of Pennsylvania, B13 Anatomy and Chemistry, 3620 Hamilton Walk, Philadelphia, PA 19104 6072, USA
Photochem Photobiol Sci 8:1683-93. 2009..This research suggests that the benefits of low-fluence-rate PDT are mediated in part by a reduction in intratumor heterogeneity in hypoxic, vascular and cytotoxic responses... 
Approaches toward combining photodynamic therapy with pharmaceuticals that alter vascular microenvironmentTheresa Busch
Department of Radiation Oncology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
Retina 29:S36-8. 2009..Clinical studies of this combination are being advanced in both AMD and in the treatment of malignancies...- Photodynamic therapy creates fluence rate-dependent gradients in the intratumoral spatial distribution of oxygenTheresa M Busch
Department of Radiation Oncology, School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104-6072, USA
Cancer Res 62:7273-9. 2002..Overall, these results demonstrate that spatially dependent depletion of oxygen can occur during PDT as a function of the fluence rate and that PDT can create significant hypoxia in even tissue adjacent to perfused blood vessels... - Correlation of in vivo photosensitizer fluorescence and photodynamic-therapy-induced depth of necrosis in a murine tumor modelRex Cheung
University of Pennsylvania, Department of Physics and Astronomy, Philadelphia, Pennsylvania 19104, USA
J Biomed Opt 8:248-52. 2003..Our observations provide further evidence that fluorescence spectroscopy can be used to quantify tissue photosensitizer uptake and to predict PDT tissue damage... - Explicit dosimetry for photodynamic therapy: macroscopic singlet oxygen modelingKen Kang Hsin Wang
Department of Radiation Oncology, University of Pennsylvania, Philadelphia, PA 19104, USA
J Biophotonics 3:304-18. 2010.... - In vivo reflectance measurement of optical properties, blood oxygenation and motexafin lutetium uptake in canine large bowels, kidneys and prostatesMichael Solonenko
Department of Physics and Astronomy, University of Pennsylvania, Philadelphia 19104, USA
Phys Med Biol 47:857-73. 2002..This class of in situ optical property measurement may be desirable to individualize PDT drug and light delivery... - Hypoxia and perfusion labeling during photodynamic therapyTheresa M Busch
Department of Radiation Oncology, School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
Methods Mol Biol 635:107-20. 2010..Taken together these data can be used to access the relative spatial distributions of hypoxia and perfusion during PDT... - Motexafin lutetium-photodynamic therapy of prostate cancer: short- and long-term effects on prostate-specific antigenHiral Patel
Department of Radiation Oncology, School of Medicine, University of Pennsylvania, Philadelphia, PA 19104 6072, USA
Clin Cancer Res 14:4869-76. 2008..The time course of serum prostate-specific antigen (PSA) response to photodynamic therapy (PDT) of prostate cancer was measured... - Effect of photosensitizer dose on fluence rate responses to photodynamic therapyHsing Wen Wang
Department of Radiation Oncology, School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
Photochem Photobiol 83:1040-8. 2007..Clinical confirmation and application of these results will be possible through use of minimally invasive oxygen and photosensitizer monitoring technologies, which are currently under development... - Photofrin uptake in the tumor and normal tissues of patients receiving intraperitoneal photodynamic therapyStephen M Hahn
Department of Radiation Oncology, School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104-6072, USA
Clin Cancer Res 12:5464-70. 2006..This narrow differential in drug selectivity likely contributes to a narrow window in therapeutic application, which has been previously reported... - Interstitial fluorescence spectroscopy in the human prostate during motexafin lutetium-mediated photodynamic therapyJarod C Finlay
Department of Radiation Oncology, University of Pennsylvania, Philadelphia, PA, USA
Photochem Photobiol 82:1270-8. 2006..These variations occur over large enough spatial scales compared with the sampling volume of the fluorescence emission that mapping the distribution in three dimensions is possible... - Real-time in situ monitoring of human prostate photodynamic therapy with diffuse lightGuoqiang Yu
Department of Physics and Astronomy, University of Pennsylvania, Philadelphia, PA, USA
Photochem Photobiol 82:1279-84. 2006.... - Interference with the Jaffé method for creatinine following 5-aminolevulinic acid administrationHarry Quon
Department of Radiation Oncology, Hospital of the University of Pennsylvania, Philadelphia, PA 19104, USA
Photodiagnosis Photodyn Ther 7:268-74. 2010..The photosensitizer pro-drug 5-aminolevulinic acid (5-ALA) has been administered systemically for photodynamic therapy. Although several toxicities have been reported, nephrotoxicity has never been observed... - Treatment-induced changes in tumor oxygenation predict photodynamic therapy outcomeHsing Wen Wang
Department of Physics and Astronomy, University of Pennsylvania, Philadelphia, Pennsylvania, USA
Cancer Res 64:7553-61. 2004..These data suggest that monitoring of PDT-induced changes in tumor oxygenation may be a valuable prognostic indicator... - Noninvasive monitoring of murine tumor blood flow during and after photodynamic therapy provides early assessment of therapeutic efficacyGuoqiang Yu
Department of Physics and Astronomy, School of Arts and Sciences, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Clin Cancer Res 11:3543-52. 2005..To monitor tumor blood flow noninvasively during photodynamic therapy (PDT) and to correlate flow responses with therapeutic efficacy... - Optical properties of human prostate at 732 nm measured in mediated photodynamic therapyTimothy C Zhu
Department of Radiation Oncology, University of Pennsylvania, 3400 Spruce Street 2 Donner, Philadelphia, PA 19104, USA
Photochem Photobiol 81:96-105. 2005.... - Pyropheophorbide 2-deoxyglucosamide: a new photosensitizer targeting glucose transportersMin Zhang
Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Bioconjug Chem 14:709-14. 2003.... - A phase II trial of intraperitoneal photodynamic therapy for patients with peritoneal carcinomatosis and sarcomatosisStephen M Hahn
Department of Radiation Oncology, Division of Gynecologic Oncology, University of Pennsylvania, Philadelphia, Pennsylvania, USA
Clin Cancer Res 12:2517-25. 2006..Heterogeneity in photosensitizer uptake and tumor oxygenation, lack of tumor specificity for photosensitizer uptake, and the heterogeneity in tissue optical properties may account for the lack of efficacy observed... - Quantitative comparison of tissue oxygen and motexafin lutetium uptake by ex vivo and noninvasive in vivo techniques in patients with intraperitoneal carcinomatosisHsing Wen Wang
University of Pennsylvania, Department of Physics, Philadelphia, Pennsylvania, USA
J Biomed Opt 12:034023. 2007..These results further demonstrate the potential of in vivo DRS measurements in clinical PDT... - Updated results of a phase I trial of motexafin lutetium-mediated interstitial photodynamic therapy in patients with locally recurrent prostate cancerKosmas Verigos
Department of Radiation Oncology, University of Pennsylvania, 3400 Spruce Street, 2 Donner, Philadelphia, PA 19104, USA
J Environ Pathol Toxicol Oncol 25:373-87. 2006..Optical property measurements demonstrated substantial heterogeneity in the optical properties of the human prostate gland which supports the use of individualized treatment planning for prostate PDT... - High payload delivery of optical imaging and photodynamic therapy agents to tumors using phthalocyanine-reconstituted low-density lipoprotein nanoparticlesHui Li
University of Pennsylvania, Department of Radiology, Philadelphia, Pennsylvania 19104, USA
J Biomed Opt 10:41203. 2005..The slopes of the linear regression fit to the logarithmic data for these two plots are significantly different from each other (p=0.0007), indicating greatly enhanced efficacy of LDLR-targeted PDT... - Multidrug resistance in photodynamic therapyTheresa M Busch
Department of Radiation Oncology, University of Pennsylvania, Philadelphia, Pennsylvania 19104-6072, USA
Cancer Biol Ther 4:195-6. 2005 - Targeted laryngeal photodynamic therapy with a balloon diffusing light sourceCraig Grossman
Department of Radiation Oncology, University of Pennsylvania, PA, USA
Photodiagnosis Photodyn Ther 7:158-61. 2010..We report a potential new application of the balloon catheter that may be more suitable for anterior glottic lesions associated with minimal acute toxicity... - Elevated serum cytokine levels in mesothelioma patients who have undergone pleurectomy or extrapleural pneumonectomy and adjuvant intraoperative photodynamic therapySue S Yom
University of Pennsylvania School of Medicine, Philadelphia, PA, USA
Photochem Photobiol 78:75-81. 2003..The results suggest a systemically mediated inflammatory response resulting from thoracic surgery followed by PDT. Further investigation of specific mechanisms is warranted... - Redox ratio of mitochondria as an indicator for the response of photodynamic therapyZhihong Zhang
Huazhong University of Science and Technology, Key Laboratory of Biomedical Photonics, Ministry of Education, Wuhan, Hubei 430074, P.R. China
J Biomed Opt 9:772-8. 2004..In the PDT treated region of the tumor, highly oxidized flavoprotein and diminishing NADH fluorescence is detected, suggesting that flavoprotein and NADH are oxidized by singlet oxygen produced in the photosensitization process... - Choice of oxygen-conserving treatment regimen determines the inflammatory response and outcome of photodynamic therapy of tumorsBarbara W Henderson
Department of Cellular Stress Biology and the Photodynamic Therapy Center, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
Cancer Res 64:2120-6. 2004..Local inflammation is not a critical factor for tumor control under optimal PDT treatment conditions... - Fluence rate as a modulator of PDT mechanismsBarbara W Henderson
Department of Cell Stress Biology, The Photodynamic Therapy Center, Roswell Park Cancer Institute, Buffalo, New York, New York 14263, USA
Lasers Surg Med 38:489-93. 2006..This article provides supporting evidence for the role of fluence rate in PDT and discusses the underlying mechanisms...
Research Grants
- EFFECTS OF PHOTODYNAMIC THERAPY ON TUMOR OXYGENATIONTheresa Busch; Fiscal Year: 2005..Investigations will be carried out using three clinically relevant photosensitizers, Photofrin, Foscan and Lutex. ..
- Effects of Photodynamic Therapy on Tumor Oxygenation and Blood FlowTheresa M Busch; Fiscal Year: 2010....
- Oxygen and photosensitizer levels in photodynamic therapy of head and neck tumorsTheresa M Busch; Fiscal Year: 2010..Compared to the alternatives of surgery or ionizing radiation, PDT offers the possible advantages of being minimally invasive, less time consuming, organ preserving, selective for diseased tissue, and amenable to repeat treatment. ..