Theresa Busch

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. pmc Tumor blood flow differs between mouse strains: consequences for vasoresponse to photodynamic therapy
    Rickson C Mesquita
    Department of Physics and Astronomy, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
    PLoS ONE 7:e37322. 2012
  2. pmc Radiation mitigating properties of the lignan component in flaxseed
    Ralph Pietrofesa
    Department of Medicine, Pulmonary, Allergy and Critical Care Division, University of Pennsylvania, 3615 Civic Center Boulevard, Abramson Research Building, Suite 1016C, Philadelphia, PA 19104, USA
    BMC Cancer 13:179. 2013
  3. pmc Fluence rate-dependent intratumor heterogeneity in physiologic and cytotoxic responses to Photofrin photodynamic therapy
    Theresa M Busch
    Department of Radiation Oncology, School of Medicine, University of Pennsylvania, B13 Anatomy and Chemistry, 3620 Hamilton Walk, Philadelphia, PA 19104 6072, USA
    Photochem Photobiol Sci 8:1683-93. 2009
  4. ncbi request reprint Hypoxia and Photofrin uptake in the intraperitoneal carcinomatosis and sarcomatosis of photodynamic therapy patients
    Theresa M Busch
    Department of Radiation Oncology, Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Clin Cancer Res 10:4630-8. 2004
  5. ncbi request reprint Local physiological changes during photodynamic therapy
    Theresa M Busch
    Department of Radiation Oncology, School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6072, USA
    Lasers Surg Med 38:494-9. 2006
  6. pmc Increasing damage to tumor blood vessels during motexafin lutetium-PDT through use of low fluence rate
    Theresa M Busch
    Department of Radiation Oncology, School of Medicine, University of Pennsylvania Philadelphia, Pennsylvania 19104, USA
    Radiat Res 174:331-40. 2010
  7. ncbi request reprint Quantitative spatial analysis of hypoxia and vascular perfusion in tumor sections
    Theresa M Busch
    Department of Radiation Oncology, School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Adv Exp Med Biol 510:37-43. 2003
  8. ncbi request reprint Approaches toward combining photodynamic therapy with pharmaceuticals that alter vascular microenvironment
    Theresa Busch
    Department of Radiation Oncology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Retina 29:S36-8. 2009
  9. ncbi request reprint Photodynamic therapy creates fluence rate-dependent gradients in the intratumoral spatial distribution of oxygen
    Theresa M Busch
    Department of Radiation Oncology, School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6072, USA
    Cancer Res 62:7273-9. 2002
  10. ncbi request reprint Correlation of in vivo photosensitizer fluorescence and photodynamic-therapy-induced depth of necrosis in a murine tumor model
    Rex Cheung
    University of Pennsylvania, Department of Physics and Astronomy, Philadelphia, Pennsylvania 19104, USA
    J Biomed Opt 8:248-52. 2003

Collaborators

Detail Information

Publications33

  1. pmc Tumor blood flow differs between mouse strains: consequences for vasoresponse to photodynamic therapy
    Rickson C Mesquita
    Department of Physics and Astronomy, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
    PLoS ONE 7:e37322. 2012
    ..These data thus identify clear effects of mouse strain on tumor hemodynamics with consequences to PDT and potentially other vascular-mediated therapies...
  2. pmc Radiation mitigating properties of the lignan component in flaxseed
    Ralph Pietrofesa
    Department of Medicine, Pulmonary, Allergy and Critical Care Division, University of Pennsylvania, 3615 Civic Center Boulevard, Abramson Research Building, Suite 1016C, Philadelphia, PA 19104, USA
    BMC Cancer 13:179. 2013
    ..This could potentially lead to pulmonary inflammation, oxidative tissue injury, and fibrosis. This study aimed to evaluate the radiation mitigating effects of FLC in a mouse model of radiation pneumonopathy...
  3. pmc Fluence rate-dependent intratumor heterogeneity in physiologic and cytotoxic responses to Photofrin photodynamic therapy
    Theresa M Busch
    Department of Radiation Oncology, School of Medicine, University of Pennsylvania, B13 Anatomy and Chemistry, 3620 Hamilton Walk, Philadelphia, PA 19104 6072, USA
    Photochem Photobiol Sci 8:1683-93. 2009
    ..This research suggests that the benefits of low-fluence-rate PDT are mediated in part by a reduction in intratumor heterogeneity in hypoxic, vascular and cytotoxic responses...
  4. ncbi request reprint Hypoxia and Photofrin uptake in the intraperitoneal carcinomatosis and sarcomatosis of photodynamic therapy patients
    Theresa M Busch
    Department of Radiation Oncology, Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Clin Cancer Res 10:4630-8. 2004
    ..The goal of this study was to investigate the presence of hypoxia and retention of the photosensitizer Photofrin in the tumors of patients with intra-abdominal carcinomatosis or sarcomatosis...
  5. ncbi request reprint Local physiological changes during photodynamic therapy
    Theresa M Busch
    Department of Radiation Oncology, School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6072, USA
    Lasers Surg Med 38:494-9. 2006
    ..Herein an overview is provided of the causes, consequences, and significance of photodynamic therapy (PDT)-mediated effects on tumor oxygenation and blood flow during illumination...
  6. pmc Increasing damage to tumor blood vessels during motexafin lutetium-PDT through use of low fluence rate
    Theresa M Busch
    Department of Radiation Oncology, School of Medicine, University of Pennsylvania Philadelphia, Pennsylvania 19104, USA
    Radiat Res 174:331-40. 2010
    ..Further study of low fluence rate as a means to improve responses to PDT under conditions designed to predominantly damage vasculature is warranted...
  7. ncbi request reprint Quantitative spatial analysis of hypoxia and vascular perfusion in tumor sections
    Theresa M Busch
    Department of Radiation Oncology, School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Adv Exp Med Biol 510:37-43. 2003
  8. ncbi request reprint Approaches toward combining photodynamic therapy with pharmaceuticals that alter vascular microenvironment
    Theresa Busch
    Department of Radiation Oncology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Retina 29:S36-8. 2009
    ..Clinical studies of this combination are being advanced in both AMD and in the treatment of malignancies...
  9. ncbi request reprint Photodynamic therapy creates fluence rate-dependent gradients in the intratumoral spatial distribution of oxygen
    Theresa M Busch
    Department of Radiation Oncology, School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6072, USA
    Cancer Res 62:7273-9. 2002
    ..Overall, these results demonstrate that spatially dependent depletion of oxygen can occur during PDT as a function of the fluence rate and that PDT can create significant hypoxia in even tissue adjacent to perfused blood vessels...
  10. ncbi request reprint Correlation of in vivo photosensitizer fluorescence and photodynamic-therapy-induced depth of necrosis in a murine tumor model
    Rex Cheung
    University of Pennsylvania, Department of Physics and Astronomy, Philadelphia, Pennsylvania 19104, USA
    J Biomed Opt 8:248-52. 2003
    ..Our observations provide further evidence that fluorescence spectroscopy can be used to quantify tissue photosensitizer uptake and to predict PDT tissue damage...
  11. pmc Explicit dosimetry for photodynamic therapy: macroscopic singlet oxygen modeling
    Ken Kang Hsin Wang
    Department of Radiation Oncology, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Biophotonics 3:304-18. 2010
    ....
  12. ncbi request reprint Hypoxia and perfusion labeling during photodynamic therapy
    Theresa M Busch
    Department of Radiation Oncology, School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
    Methods Mol Biol 635:107-20. 2010
    ..Taken together these data can be used to access the relative spatial distributions of hypoxia and perfusion during PDT...
  13. ncbi request reprint In vivo reflectance measurement of optical properties, blood oxygenation and motexafin lutetium uptake in canine large bowels, kidneys and prostates
    Michael Solonenko
    Department of Physics and Astronomy, University of Pennsylvania, Philadelphia 19104, USA
    Phys Med Biol 47:857-73. 2002
    ..This class of in situ optical property measurement may be desirable to individualize PDT drug and light delivery...
  14. pmc Motexafin lutetium-photodynamic therapy of prostate cancer: short- and long-term effects on prostate-specific antigen
    Hiral Patel
    Department of Radiation Oncology, School of Medicine, University of Pennsylvania, Philadelphia, PA 19104 6072, USA
    Clin Cancer Res 14:4869-76. 2008
    ..The time course of serum prostate-specific antigen (PSA) response to photodynamic therapy (PDT) of prostate cancer was measured...
  15. ncbi request reprint Photofrin uptake in the tumor and normal tissues of patients receiving intraperitoneal photodynamic therapy
    Stephen M Hahn
    Department of Radiation Oncology, School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6072, USA
    Clin Cancer Res 12:5464-70. 2006
    ..photodynamic therapy shown in a previous report limited efficacy and significant acute, but not chronic, toxicity. A secondary aim of this trial and the subject of this report is to determine Photofrin uptake in tumor and normal tissues...
  16. ncbi request reprint Interstitial fluorescence spectroscopy in the human prostate during motexafin lutetium-mediated photodynamic therapy
    Jarod C Finlay
    Department of Radiation Oncology, University of Pennsylvania, Philadelphia, PA, USA
    Photochem Photobiol 82:1270-8. 2006
    ..These variations occur over large enough spatial scales compared with the sampling volume of the fluorescence emission that mapping the distribution in three dimensions is possible...
  17. ncbi request reprint Treatment-induced changes in tumor oxygenation predict photodynamic therapy outcome
    Hsing Wen Wang
    Department of Physics and Astronomy, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Cancer Res 64:7553-61. 2004
    ..These data suggest that monitoring of PDT-induced changes in tumor oxygenation may be a valuable prognostic indicator...
  18. ncbi request reprint Real-time in situ monitoring of human prostate photodynamic therapy with diffuse light
    Guoqiang Yu
    Department of Physics and Astronomy, University of Pennsylvania, Philadelphia, PA, USA
    Photochem Photobiol 82:1279-84. 2006
    ....
  19. ncbi request reprint Noninvasive monitoring of murine tumor blood flow during and after photodynamic therapy provides early assessment of therapeutic efficacy
    Guoqiang Yu
    Department of Physics and Astronomy, School of Arts and Sciences, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Clin Cancer Res 11:3543-52. 2005
    ..To monitor tumor blood flow noninvasively during photodynamic therapy (PDT) and to correlate flow responses with therapeutic efficacy...
  20. pmc Interference with the Jaffé method for creatinine following 5-aminolevulinic acid administration
    Harry Quon
    Department of Radiation Oncology, Hospital of the University of Pennsylvania, Philadelphia, PA 19104, USA
    Photodiagnosis Photodyn Ther 7:268-74. 2010
    ..The photosensitizer pro-drug 5-aminolevulinic acid (5-ALA) has been administered systemically for photodynamic therapy. Although several toxicities have been reported, nephrotoxicity has never been observed...
  21. ncbi request reprint Effect of photosensitizer dose on fluence rate responses to photodynamic therapy
    Hsing Wen Wang
    Department of Radiation Oncology, School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
    Photochem Photobiol 83:1040-8. 2007
    ..Clinical confirmation and application of these results will be possible through use of minimally invasive oxygen and photosensitizer monitoring technologies, which are currently under development...
  22. ncbi request reprint Optical properties of human prostate at 732 nm measured in mediated photodynamic therapy
    Timothy C Zhu
    Department of Radiation Oncology, University of Pennsylvania, 3400 Spruce Street 2 Donner, Philadelphia, PA 19104, USA
    Photochem Photobiol 81:96-105. 2005
    ....
  23. ncbi request reprint Pyropheophorbide 2-deoxyglucosamide: a new photosensitizer targeting glucose transporters
    Min Zhang
    Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Bioconjug Chem 14:709-14. 2003
    ....
  24. ncbi request reprint A phase II trial of intraperitoneal photodynamic therapy for patients with peritoneal carcinomatosis and sarcomatosis
    Stephen M Hahn
    Department of Radiation Oncology, Division of Gynecologic Oncology, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Clin Cancer Res 12:2517-25. 2006
    ..The primary objectives of this phase II study were to determine the efficacy and toxicities of i.p. photodynamic therapy in patients with peritoneal carcinomatosis and sarcomatosis...
  25. ncbi request reprint Quantitative comparison of tissue oxygen and motexafin lutetium uptake by ex vivo and noninvasive in vivo techniques in patients with intraperitoneal carcinomatosis
    Hsing Wen Wang
    University of Pennsylvania, Department of Physics, Philadelphia, Pennsylvania, USA
    J Biomed Opt 12:034023. 2007
    ..These results further demonstrate the potential of in vivo DRS measurements in clinical PDT...
  26. ncbi request reprint Updated results of a phase I trial of motexafin lutetium-mediated interstitial photodynamic therapy in patients with locally recurrent prostate cancer
    Kosmas Verigos
    Department of Radiation Oncology, University of Pennsylvania, 3400 Spruce Street, 2 Donner, Philadelphia, PA 19104, USA
    J Environ Pathol Toxicol Oncol 25:373-87. 2006
    ..Optical property measurements demonstrated substantial heterogeneity in the optical properties of the human prostate gland which supports the use of individualized treatment planning for prostate PDT...
  27. ncbi request reprint High payload delivery of optical imaging and photodynamic therapy agents to tumors using phthalocyanine-reconstituted low-density lipoprotein nanoparticles
    Hui Li
    University of Pennsylvania, Department of Radiology, Philadelphia, Pennsylvania 19104, USA
    J Biomed Opt 10:41203. 2005
    ..The slopes of the linear regression fit to the logarithmic data for these two plots are significantly different from each other (p=0.0007), indicating greatly enhanced efficacy of LDLR-targeted PDT...
  28. ncbi request reprint Multidrug resistance in photodynamic therapy
    Theresa M Busch
    Department of Radiation Oncology, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6072, USA
    Cancer Biol Ther 4:195-6. 2005
  29. pmc Targeted laryngeal photodynamic therapy with a balloon diffusing light source
    Craig Grossman
    Department of Radiation Oncology, University of Pennsylvania, PA, USA
    Photodiagnosis Photodyn Ther 7:158-61. 2010
    ..We report a potential new application of the balloon catheter that may be more suitable for anterior glottic lesions associated with minimal acute toxicity...
  30. ncbi request reprint Elevated serum cytokine levels in mesothelioma patients who have undergone pleurectomy or extrapleural pneumonectomy and adjuvant intraoperative photodynamic therapy
    Sue S Yom
    University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Photochem Photobiol 78:75-81. 2003
    ..The results suggest a systemically mediated inflammatory response resulting from thoracic surgery followed by PDT. Further investigation of specific mechanisms is warranted...
  31. ncbi request reprint Redox ratio of mitochondria as an indicator for the response of photodynamic therapy
    Zhihong Zhang
    Huazhong University of Science and Technology, Key Laboratory of Biomedical Photonics, Ministry of Education, Wuhan, Hubei 430074, P R China
    J Biomed Opt 9:772-8. 2004
    ..In the PDT treated region of the tumor, highly oxidized flavoprotein and diminishing NADH fluorescence is detected, suggesting that flavoprotein and NADH are oxidized by singlet oxygen produced in the photosensitization process...
  32. ncbi request reprint Choice of oxygen-conserving treatment regimen determines the inflammatory response and outcome of photodynamic therapy of tumors
    Barbara W Henderson
    Department of Cellular Stress Biology and the Photodynamic Therapy Center, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
    Cancer Res 64:2120-6. 2004
    ..Local inflammation is not a critical factor for tumor control under optimal PDT treatment conditions...
  33. ncbi request reprint Fluence rate as a modulator of PDT mechanisms
    Barbara W Henderson
    Department of Cell Stress Biology, The Photodynamic Therapy Center, Roswell Park Cancer Institute, Buffalo, New York, New York 14263, USA
    Lasers Surg Med 38:489-93. 2006
    ..This article provides supporting evidence for the role of fluence rate in PDT and discusses the underlying mechanisms...

Research Grants9

  1. EFFECTS OF PHOTODYNAMIC THERAPY ON TUMOR OXYGENATION
    Theresa Busch; Fiscal Year: 2002
    ..Investigations will be carried out using three clinically relevant photosensitizers, Photofrin, Foscan and Lutex. ..
  2. EFFECTS OF PHOTODYNAMIC THERAPY ON TUMOR OXYGENATION
    Theresa Busch; Fiscal Year: 2003
    ..Investigations will be carried out using three clinically relevant photosensitizers, Photofrin, Foscan and Lutex. ..
  3. EFFECTS OF PHOTODYNAMIC THERAPY ON TUMOR OXYGENATION
    Theresa Busch; Fiscal Year: 2004
    ..Investigations will be carried out using three clinically relevant photosensitizers, Photofrin, Foscan and Lutex. ..
  4. EFFECTS OF PHOTODYNAMIC THERAPY ON TUMOR OXYGENATION
    Theresa Busch; Fiscal Year: 2005
    ..Investigations will be carried out using three clinically relevant photosensitizers, Photofrin, Foscan and Lutex. ..
  5. Effects of Photodynamic Therapy on Tumor Oxygenation and Blood Flow
    Theresa Busch; Fiscal Year: 2009
    ....
  6. Oxygen and photosensitizer levels in photodynamic therapy of head and neck tumors
    Theresa Busch; Fiscal Year: 2009
    ..Compared to the alternatives of surgery or ionizing radiation, PDT offers the possible advantages of being minimally invasive, less time consuming, organ preserving, selective for diseased tissue, and amenable to repeat treatment. ..
  7. Effects of Photodynamic Therapy on Tumor Oxygenation and Blood Flow
    Theresa M Busch; Fiscal Year: 2010
    ....
  8. Oxygen and photosensitizer levels in photodynamic therapy of head and neck tumors
    Theresa M Busch; Fiscal Year: 2010
    ..Compared to the alternatives of surgery or ionizing radiation, PDT offers the possible advantages of being minimally invasive, less time consuming, organ preserving, selective for diseased tissue, and amenable to repeat treatment. ..