Randall W Burt

Summary

Affiliation: University of Utah
Country: USA

Publications

  1. ncbi Hamartomatous polyposis syndromes
    Amanda Gammon
    Huntsman Cancer Institute, 2000 Circle of Hope, Salt Lake City, UT 84112 5550, USA
    Best Pract Res Clin Gastroenterol 23:219-31. 2009
  2. ncbi Diagnosing Lynch syndrome: more light at the end of the tunnel
    Randall W Burt
    Department of Medicine, School of Medicine, Huntsman Cancer Institute, University of Utah, 2000 Circle of Hope, Salt Lake City, UT 84112, USA
    Cancer Prev Res (Phila) 5:507-10. 2012
  3. ncbi Genetic testing and phenotype in a large kindred with attenuated familial adenomatous polyposis
    Randall W Burt
    Department of Medicine, University of Utah, Salt Lake City, USA
    Gastroenterology 127:444-51. 2004
  4. ncbi Gastric fundic gland polyps
    Randall W Burt
    Depsartment of Medicine, Huntsman Cancer Institute, University of Utah, 2000 Circle of Hope, Salt Lake City, UT 84112, USA
    Gastroenterology 125:1462-9. 2003
  5. ncbi Colorectal cancer screening
    Randall W Burt
    Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah 84112, USA
    Curr Opin Gastroenterol 26:466-70. 2010
  6. ncbi Genetic testing for inherited colon cancer
    Randall Burt
    Huntsman Cancer Institute at University of Utah, Salt Lake City, Utah 84112, USA
    Gastroenterology 128:1696-716. 2005
  7. ncbi Hereditary and familial colon cancer
    Kory W Jasperson
    Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah, USA
    Gastroenterology 138:2044-58. 2010
  8. ncbi A two-step model for colon adenoma initiation and progression caused by APC loss
    Reid A Phelps
    Huntsman Cancer Institute, University of Utah, Salt Lake City, UT 84112, USA
    Cell 137:623-34. 2009
  9. ncbi Colorectal adenomas and cancer link to chromosome 13q22.1-13q31.3 in a large family with excess colorectal cancer
    Deborah W Neklason
    Department of Oncological Sciences, University of Utah, Salt Lake City, Utah, USA
    J Med Genet 47:692-9. 2010
  10. ncbi Activating mutation in MET oncogene in familial colorectal cancer
    Deborah W Neklason
    Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah, USA
    BMC Cancer 11:424. 2011

Research Grants

  1. EFFECTS OF ENVIRONMENT AND INHERITANCE ON COLONIC POLYPS
    Randall Burt; Fiscal Year: 1993
  2. HIGH RISK FAMILIAL COLON CANCER--GENETICS AND PHENOTYPE
    Randall Burt; Fiscal Year: 2001
  3. INCREASING COLORECTAL CANCER SCREENING
    Randall Burt; Fiscal Year: 2005
  4. HIGH RISK FAMILIAL COLON CANCER- GENETICS AND PHENOTYPE
    Randall Burt; Fiscal Year: 2007
  5. INHERITANCE OF DISCRETE COLORECTAL ADENOMATOUS POLYPS
    Randall Burt; Fiscal Year: 1990
  6. MOLECULAR/CLINICAL APPROACHES TO COLON CANCER PRECURSORS
    Randall Burt; Fiscal Year: 2007

Detail Information

Publications50

  1. ncbi Hamartomatous polyposis syndromes
    Amanda Gammon
    Huntsman Cancer Institute, 2000 Circle of Hope, Salt Lake City, UT 84112 5550, USA
    Best Pract Res Clin Gastroenterol 23:219-31. 2009
    ....
  2. ncbi Diagnosing Lynch syndrome: more light at the end of the tunnel
    Randall W Burt
    Department of Medicine, School of Medicine, Huntsman Cancer Institute, University of Utah, 2000 Circle of Hope, Salt Lake City, UT 84112, USA
    Cancer Prev Res (Phila) 5:507-10. 2012
    ....
  3. ncbi Genetic testing and phenotype in a large kindred with attenuated familial adenomatous polyposis
    Randall W Burt
    Department of Medicine, University of Utah, Salt Lake City, USA
    Gastroenterology 127:444-51. 2004
    ..An attenuated form of familial adenomatous polyposis has been described, but the phenotype remains poorly understood...
  4. ncbi Gastric fundic gland polyps
    Randall W Burt
    Depsartment of Medicine, Huntsman Cancer Institute, University of Utah, 2000 Circle of Hope, Salt Lake City, UT 84112, USA
    Gastroenterology 125:1462-9. 2003
  5. ncbi Colorectal cancer screening
    Randall W Burt
    Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah 84112, USA
    Curr Opin Gastroenterol 26:466-70. 2010
    ..Recently published screening guidelines will be reviewed so physicians can understand them and how to deal with the differences. Each screening modality presently in use will then be reviewed with emphasis on efficacy and problems...
  6. ncbi Genetic testing for inherited colon cancer
    Randall Burt
    Huntsman Cancer Institute at University of Utah, Salt Lake City, Utah 84112, USA
    Gastroenterology 128:1696-716. 2005
    ..Finally, the ongoing work to discover new and possibly more common but less penetrant colon cancer susceptibility genes that cause common familial colon cancer will be presented...
  7. ncbi Hereditary and familial colon cancer
    Kory W Jasperson
    Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah, USA
    Gastroenterology 138:2044-58. 2010
    ..This review examines the colon cancer syndromes, their genetics and management, and also the common familial colon cancers with current genetic advances and screening guidelines...
  8. ncbi A two-step model for colon adenoma initiation and progression caused by APC loss
    Reid A Phelps
    Huntsman Cancer Institute, University of Utah, Salt Lake City, UT 84112, USA
    Cell 137:623-34. 2009
    ..Consistent with this model, human FAP adenomas showed robust upregulation of CtBP1 in the absence of detectable nuclear beta-catenin, whereas nuclear beta-catenin was detected in carcinomas...
  9. ncbi Colorectal adenomas and cancer link to chromosome 13q22.1-13q31.3 in a large family with excess colorectal cancer
    Deborah W Neklason
    Department of Oncological Sciences, University of Utah, Salt Lake City, Utah, USA
    J Med Genet 47:692-9. 2010
    ..Fewer than 5% of colon cancers arise in the presence of a clear hereditary cancer condition; however, current estimates suggest that an additional 15-25% of colorectal cancers arise on the basis of unknown inherited factors...
  10. ncbi Activating mutation in MET oncogene in familial colorectal cancer
    Deborah W Neklason
    Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah, USA
    BMC Cancer 11:424. 2011
    ..Familial colorectal cancer has been linked to chromosome 7q31 by multiple affected relative pair studies. The MET proto-oncogene which resides in this chromosomal region is considered a candidate for genetic susceptibility...
  11. ncbi Parental attitudes, beliefs, and perceptions about genetic testing for FAP and colorectal cancer surveillance in minors
    Fallon R Levine
    Division of Medical Genetics, Department of Pediatrics, University of Utah, Salt Lake City, UT, USA
    J Genet Couns 19:269-79. 2010
    ..Most commonly reported barriers included lack of provider recommendation (surveillance) and cost (genetic testing)...
  12. ncbi Colonic adenoma risk in familial colorectal cancer--a study of six extended kindreds
    Deborah W Neklason
    Huntsman Cancer Institute, Salt Lake City, Utah 84112 5550, USA
    Am J Gastroenterol 103:2577-84. 2008
    ..This issue is clinically relevant since several medical societies currently recommend earlier and more rigorous colorectal screening for individuals with a strong family history of CRC...
  13. ncbi American founder mutation for attenuated familial adenomatous polyposis
    Deborah W Neklason
    Department of Oncological Sciences, University of Utah, Salt Lake City, Utah 84112 5550, USA
    Clin Gastroenterol Hepatol 6:46-52. 2008
    ....
  14. ncbi Comparison of compliance for colorectal cancer screening and surveillance by colonoscopy based on risk
    David P Taylor
    Department of Biomedical Informatics, University of Utah, School of Medicine, Salt Lake City, Utah 84112 5750, USA
    Genet Med 13:737-43. 2011
    ..To compare colonoscopy screening/surveillance rates by level of risk for colorectal cancer based on age, personal history of adenomatous polyps or colorectal cancer, or family history of colorectal cancer...
  15. ncbi Large intron 14 rearrangement in APC results in splice defect and attenuated FAP
    Therese M F Tuohy
    Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, 84112 5550, USA
    Hum Genet 127:359-69. 2010
    ..This and similar types of intronic mutations may account for a significant proportion of FAP cases where APC clinical analysis fails because of the current limitations of testing options...
  16. ncbi Population-based family history-specific risks for colorectal cancer: a constellation approach
    David P Taylor
    Department of Biomedical Informatics, University of Utah, Salt Lake City, Utah
    Gastroenterology 138:877-85. 2010
    ..We report familial relative risk (FRR) in probands with various combinations, or constellations, of affected relatives, extending to third-degree...
  17. ncbi Frequency of familial colon cancer and hereditary nonpolyposis colorectal cancer (Lynch syndrome) in a large population database
    Richard A Kerber
    Department of Oncological Sciences, University of Utah, School of Medicine, USA
    Fam Cancer 4:239-44. 2005
    ..Less than half of a limited set of tumors from Amsterdam families were MSI positive...
  18. ncbi Intron 4 mutation in APC gene results in splice defect and attenuated FAP phenotype
    Deborah W Neklason
    Department of Oncological Sciences, University of Utah, Salt Lake City, USA
    Fam Cancer 3:35-40. 2004
    ..The lack of a secondary transcript from the mutant allele suggests that incomplete exon skipping is not the molecular mechanism behind the attenuated phenotype...
  19. ncbi How well does family history predict who will get colorectal cancer? Implications for cancer screening and counseling
    David P Taylor
    Department of Biomedical Informatics, University of Utah School of Medicine, Salt Lake City, Utah 84112 5750, USA
    Genet Med 13:385-91. 2011
    ..Using a large, retrospective cohort from the Utah Population Database, we assess how well family history predicts who will acquire colorectal cancer during a 20-year period...
  20. ncbi Gonadal mosaicism and familial adenomatous polyposis
    Angela L Schwab
    Huntsman Cancer Institute, University of Utah, 2000 Circle of Hope, Room 3146, Salt Lake City, UT 84112 5550, USA
    Fam Cancer 7:173-7. 2008
    ..Parents who test negative for the mutation should be counseled about the possibility of having another affected child due to gonadal mosaicism...
  21. ncbi Somatic mosaicism: a cause for unexplained cases of FAP?
    Therese M Tuohy
    High Risk Cancer Clinics, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT 84112, USA
    Gut 57:10-2. 2008
  22. ncbi Maximum-likelihood estimation of recent shared ancestry (ERSA)
    Chad D Huff
    Department of Human Genetics, University of Utah Health Sciences Center, Salt Lake City, Utah 84112, USA
    Genome Res 21:768-74. 2011
    ..ERSA greatly expands the range of relationships that can be estimated from genetic data and is implemented in a freely available software package...
  23. ncbi A familial component to human rectal cancer, independent of colon cancer risk
    John Scott Maul
    Department of Medical Oncology, University of Utah School of Medicine, Salt Lake City, Utah, USA
    Clin Gastroenterol Hepatol 5:1080-4. 2007
    ..The Utah Population Database (UPDB) is unique; it links genealogy for over 2 million Utah individuals to a statewide Cancer Registry. We have investigated the familial nature of rectal cancer, considered independently from colon cancer...
  24. ncbi Disease-associated casein kinase I delta mutation may promote adenomatous polyps formation via a Wnt/beta-catenin independent mechanism
    I Chun Tsai
    Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT 84112, USA
    Int J Cancer 120:1005-12. 2007
    ..This novel human CKIdelta mutation may alter the physiological role and enhance the transforming ability of CKIdelta through a Wnt/beta-catenin independent mechanism and thereby influence colonic adenoma development...
  25. ncbi A population-based study of subsequent primary malignancies after endometrial cancer: genetic, environmental, and treatment-related associations
    Aaron P Brown
    Department of Radiation Oncology, University of Utah, Salt Lake City, UT 84112, USA
    Int J Radiat Oncol Biol Phys 78:127-35. 2010
    ..To examine the risk of subsequent primary malignancies (SPMs) in women diagnosed with endometrial cancer...
  26. ncbi Guidelines for colonoscopy surveillance after polypectomy: a consensus update by the US Multi-Society Task Force on Colorectal Cancer and the American Cancer Society
    Sidney J Winawer
    Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY, USA
    CA Cancer J Clin 56:143-59; quiz 184-5. 2006
    ..It has been shown that the first screening colonoscopy and polypectomy produces the greatest effects on reducing the incidence of colorectal cancer in patients with adenomatous polyps...
  27. ncbi Adenomatous polyposis coli control of C-terminal binding protein-1 stability regulates expression of intestinal retinol dehydrogenases
    Lincoln D Nadauld
    Department of Oncological Sciences, University of Utah, Salt Lake City, Utah 84112, USA
    J Biol Chem 281:37828-35. 2006
    ..The relationship between APC and CtBP1 is conserved between humans and zebrafish and provides a mechanistic model explaining APC control of intestinal retinoic acid biosynthesis...
  28. ncbi Colorectal cancer surveillance behaviors among members of typical and attenuated FAP families
    Anita Y Kinney
    Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah 84112, USA
    Am J Gastroenterol 102:153-62. 2007
    ..This study examined factors associated with recent use of colorectal cancer (CRC) surveillance among FAP patients and their at-risk relatives...
  29. ncbi Evaluating Lynch syndrome in very early onset colorectal cancer probands without apparent polyposis
    Kory W Jasperson
    Cancer Screening and Prevention Program, City of Hope Cancer Center, Duarte, CA, USA
    Fam Cancer 9:99-107. 2010
    ..Careful attention to evolving or additional clinical features is warranted and may lead to an alternate genetic diagnosis in families with early onset CRC...
  30. ncbi Can we identify the high-risk patients to be screened? A genetic approach
    Amanda Gammon
    Department of Medicine, University of Utah, Salt Lake City, UT 84112 5550, USA
    Digestion 76:7-19. 2007
    ..Through this review, we hope to show that the identification of high-risk patients is possible, though sometimes difficult...
  31. ncbi Improving colonoscopy referral rates through computer-supported, primary care practice redesign
    Michael K Magill
    Department of Family and Preventive Medicine, University Hospital Community Clinics, University of Utah, USA
    J Healthc Qual 31:43-52; quiz 52-3. 2009
    ..This study demonstrates that a robust EMR, with decision prompts, accompanied by clinic workflow changes and feedback to providers, can lead to sustained change in the rates of colonoscopy referral...
  32. ncbi Phenotypic characteristics and risk of cancer development in hyperplastic polyposis: case series and literature review
    Angel Ferrandez
    Department of Prevention and Outreach, Huntsman Cancer Institute, University of Utah, 2000 Circle of Hope, Salt Lake City, UT 84112, USA
    Am J Gastroenterol 99:2012-8. 2004
    ..Hyperplastic polyposis (HP) is a poorly understood condition. The aim of this study is to describe the phenotype and the risk of cancer in HP...
  33. ncbi A population-based description of familial clustering of pancreatic cancer
    Brian H Shirts
    Department of Pathology, University of Utah, Salt Lake City, Utah, USA
    Clin Gastroenterol Hepatol 8:812-6. 2010
    ..Several familial pancreatic cancer syndromes have been identified. However, the prevalence of familial pancreatic cancers in the general population has not been well defined...
  34. ncbi Common familial colorectal cancer linked to chromosome 7q31: a genome-wide analysis
    Deborah W Neklason
    Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah 84112 5550, USA
    Cancer Res 68:8993-7. 2008
    ..9; P = 0.02). No known familial cancer genes reside in the 7q31 locus, and thus the identified region may contain a novel susceptibility gene responsible for common familial colorectal cancer...
  35. ncbi Lynch syndrome screening implementation: business analysis by a healthcare system
    James M Gudgeon
    Clinical Genetics Institute, Intermountain Healthcare, Salt Lake City, UT 84103, USA
    Am J Manag Care 17:e288-300. 2011
    ....
  36. ncbi Shared genomic segment analysis: the power to find rare disease variants
    Stacey Knight
    Division of Genetic Epidemiology, University of Utah School of Medicine, Salt Lake City, UT, USA Heart Institute, Intermountain Medical Center, Murray, UT, USA Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA
    Ann Hum Genet 76:500-9. 2012
    ..96 Mb region containing the known causal APC gene with genome-wide significance. SGS is a powerful method for detecting rare variants and a valuable complement to genome-wide association studies and linkage analysis...
  37. ncbi Extracolonic cancers associated with hereditary nonpolyposis colorectal cancer in the Utah Population Database
    John Scott Maul
    Department of Cancer Outreach and Prevention, Huntsman Cancer Institute, Salt Lake City, Utah, USA
    Am J Gastroenterol 101:1591-6. 2006
    ..Although our sample size is small, this study is population based, lacks ascertainment and recall bias, and benefits from uniform, consistent diagnoses of all cancers in a statewide registry...
  38. ncbi Abdominal desmoid in familial adenomatous polyposis presenting as a pancreatic cystic lesion
    Lana N Pho
    Department of Medicine, School of Medicine and Huntsman Cancer Institute, University of Utah, 2000 Circle of Hope, Salt Lake City, UT 84112, USA
    Fam Cancer 4:135-8. 2005
    ..This case report provides the first pathologic evidence for benign epithelial cyst formation in the pancreas caused by fibromatosis invasion of that organ as a part of FAP...
  39. ncbi "Hot spots" can burn you
    Jason C Wills
    Department of Gastroenterology, University of Utah, Salt Lake City, USA
    Am J Gastroenterol 97:757-8. 2002
  40. ncbi Presentation of the Julius M. Friedenwald Medal to James W. Freston, MD, PhD
    Randall W Burt
    University of Utah School of Medicine, Huntsman Cancer Institute, Salt Lake City, Utah, USA
    Gastroenterology 132:2580-4. 2007
  41. ncbi DNA demethylase activity maintains intestinal cells in an undifferentiated state following loss of APC
    Kunal Rai
    Huntsman Cancer Institute, University of Utah, Salt Lake City, UT 84112, USA
    Cell 142:930-42. 2010
    ..Wild-type APC and retinoic acid downregulate demethylase components, thereby promoting DNA methylation of key genes and helping progenitors commit to differentiation...
  42. ncbi Colorectal cancer screening
    Brad Trowbridge
    Division of Gastroenterology, Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City 84132, USA
    Surg Clin North Am 82:943-57. 2002
    ..Currently, screening the average risk population over the age of 50 would reduce mortality from colon cancer by 50%. Future advances will likely include improved screening tests, and the development of familial genetic testing...
  43. ncbi Guidelines for colonoscopy surveillance after polypectomy: a consensus update by the US Multi-Society Task Force on Colorectal Cancer and the American Cancer Society
    Sidney J Winawer
    Memorial Sloan Kettering Cancer Center, New York, New York, USA
    Gastroenterology 130:1872-85. 2006
    ..It has been shown that the first screening colonoscopy and polypectomy produces the greatest effects on reducing the incidence of colorectal cancer in patients with adenomatous polyps...
  44. ncbi Current status of genetic testing for colorectal cancer susceptibility
    Cindy Hoyle Solomon
    Division of Gastroenterology, Huntsman Cancer Institute at the University of Utah, Salt Lake City 84112, USA
    Oncology (Williston Park) 16:161-71; discussion 176, 179-80. 2002
    ....
  45. ncbi Guidelines for colonoscopy surveillance after cancer resection: a consensus update by the American Cancer Society and the US Multi-Society Task Force on Colorectal Cancer
    Douglas K Rex
    Indiana University School of Medicine, Indianapolis, Indiana, USA
    Gastroenterology 130:1865-71. 2006
    ....
  46. ncbi Colorectal Cancer Screening Clinical Practice Guidelines
    Bernard Levin
    J Natl Compr Canc Netw 4:384-420. 2006
  47. ncbi Guidelines for colonoscopy surveillance after cancer resection: a consensus update by the American Cancer Society and US Multi-Society Task Force on Colorectal Cancer
    Douglas K Rex
    Indiana University School of Medicine, Indianapolis, IN, USA
    CA Cancer J Clin 56:160-7; quiz 185-6. 2006
    ....
  48. ncbi Quality in the technical performance of colonoscopy and the continuous quality improvement process for colonoscopy: recommendations of the U.S. Multi-Society Task Force on Colorectal Cancer
    Douglas K Rex
    Department of Medicine/Gastroenterology, Indiana University Medical Center, Indianapolis, USA
    Am J Gastroenterol 97:1296-308. 2002
  49. ncbi Molecular and clinical characteristics in 46 families affected with Peutz-Jeghers syndrome
    Hamid Mehenni
    Centre Médico Chirurgical Rond Point Plainpalais et Département de biologie cellulaire, Unité de recherche des maladies prédisposant aux cancers gastro intestinaux, Universite de Geneve, Geneve, Switzerland
    Dig Dis Sci 52:1924-33. 2007
    ....
  50. ncbi Inherited polyposis syndromes: molecular mechanisms, clinicopathology, and genetic testing
    Brett W Doxey
    Division of Gastroenterology, University of Utah Health Sciences Center, USA
    Clin Gastroenterol Hepatol 3:633-41. 2005
    ..There are many issues accompanying molecular diagnosis of cancer syndromes, and genetic counseling is an essential prelude to genetic testing...

Research Grants24

  1. EFFECTS OF ENVIRONMENT AND INHERITANCE ON COLONIC POLYPS
    Randall Burt; Fiscal Year: 1993
    ..The investigation is significant because it provides the first opportunity to study the effects of environmental risk factors on the development of adenomatous polyps in the setting where individual genetic susceptibility is known...
  2. HIGH RISK FAMILIAL COLON CANCER--GENETICS AND PHENOTYPE
    Randall Burt; Fiscal Year: 2001
    ....
  3. INCREASING COLORECTAL CANCER SCREENING
    Randall Burt; Fiscal Year: 2005
    ..abstract_text> ..
  4. HIGH RISK FAMILIAL COLON CANCER- GENETICS AND PHENOTYPE
    Randall Burt; Fiscal Year: 2007
    ....
  5. INHERITANCE OF DISCRETE COLORECTAL ADENOMATOUS POLYPS
    Randall Burt; Fiscal Year: 1990
    ..The population characterized by this study will also provide the basis for DNA marker linkage studies, subsequent studies of gene-environment interactions, and studies of molecular mechanisms of cancer...
  6. MOLECULAR/CLINICAL APPROACHES TO COLON CANCER PRECURSORS
    Randall Burt; Fiscal Year: 2007
    ..abstract_text> ..